Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
GRB2 ACTN4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
HRAS ARAF â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 34591642
ARAF MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18039929
CREB5 ATF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8378084 8440710
EWSR1 BAD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
GRB2 BAD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
UBE3A BAK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 9881696 6548460
CASP8 CASP3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18669646 0712034105
AKT3 CASP3 â—¼   CLEAVAGE ✅ 2.0 0.8 intact 17544405 5219985
GSN CASP3 â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 9323209 9930654
CASP3 AKT1 â—¼   CLEAVAGE ✅ 2.0 0.8 intact 17544405 5219985
CASP3 AKT2 â—¼   CLEAVAGE ✅ 2.0 0.8 intact 17544405 5219985
HDAC3 CCND1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16461912 0506281103
ATF4 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18729081 20101207
MAPK1 CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17205132
GSN CDK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HRAS CDK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
GRIN2C CDK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
GSN CDKN1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SKP2 CDKN1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16376880 5218183
HDAC11 CDKN1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
CDKN1A CCND3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
AKT1 CDKN1A â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12244303 11231573
EGR2 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16708405 18779345
ING4 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20707719 15882981
CCNA1 CDKN1A â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
PLCG2 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 31575057
PLCG1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 31575057
TRAF2 CDKN1B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
CDKN1B CCND2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
AKT1 CDKN1B â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12244303 11231573
ING4 CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20707719 18399550
CCNA1 CDKN1B â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
CDKN2A CDK4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15232106 5217098
CDKN2A CDK6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15232106 5217098
DDB1 IKBKG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
DNAJA3 USP7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
EP300 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23403292 24998469
EP300 CDKN2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22000024 19419955
EP300 H2AX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20488183
EP300 H2AZ1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19056256
EP300 H2BC11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19056256
PLCG2 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
CD80 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9694876 7737275
CD86 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9694876 7737275
LCK GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9694876 7737275
GRB2 H2AC18 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 ACTG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 C6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
GRB2 ACTN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 SCIN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 GSN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
MAPK1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8994038
ACTG1 IKBKG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
TRAF2 IRF7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15361868 19479062
RAF1 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 20674547 15664191
PRKCB MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8903320 10327068
MAPK1 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15263086 15466214
MAPK1 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8941362
MAPK11 MAPK14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23602568 21900206
MAPK14 ELK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9130707
MAPKAPK2 MAPK11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8622669 7535770
EWSR1 USP7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
CREB3L3 USP7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
H2AX H2BC14 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H2AX H2BC12L â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
CDK6 CCND3 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
CREB1 CDK6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20864035
CREB1 IL10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21084670
CALM3 CAMKK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9822657 10187789
CALM3 CAMK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8340352 20668654
CALM1 AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12799359 11988487
CALM1 CAMK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8340352 20668654
CALM1 CAMKK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10770941 7642608
DRD1 GNAI3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1832710 31160049
ACTG1 TRAF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
CALM2 CAMK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8340352 20668654
CALM2 CAMKK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9822657 10187789
PIK3R2 LCK â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15536084 11907067
LCK CD28 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8946678 9973466
LCK CD86 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8946678 9973466
LCK CD80 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8946678 9973466
LCK DLG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5221707 9341123
HLA-DRA LCK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
HLA-DQA1 LCK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
FCGR2A PLCG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7517665 8657103
FCGR1A PLCG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7517665 8657103
GRIN2A PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9231720
ADORA2A GNAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8995267 6162091
DRD1 GNAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1832710 2898118
NCF4 CYBA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5223350 17803994
CASP8 RAF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RAF1 AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19197339 7014125
HRAS GTF2A1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
EWSR1 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 8552387 12459554
CDC42 EIF2AK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7738010 5220554
CDK4 CCND2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
EGR3 EGR2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9915863 20506119
CREB1 CCR5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18511806 24832521
CREB1 CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17043650 16301994
MAPK11 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11532940 11335727
GNB5 PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23109003 17169327
GNAI1 GNG2 â—¼   PROXIMITY 2.0 0.8 intact 8189321 21552208
GNB1 GNAI2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7102203 16782902
HLA-DRA HLA-DQA1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CCND3 CCNE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16609025
MAPK11 ELK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9130707 9235954
DRD2 SLC6A3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17380124
DRD2 GNAO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1445393 31160049
YWHAH GP1BA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19558434 8009025
H2BC12L BDNF â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
EGR3 BDNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22035109 16901909
PIK3R2 FCGR1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12869549 15536084
PIK3R2 FCGR2A â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12869549 15536084
PIK3R2 FCGR3A â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12869549 15536084
GNG4 PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23109003 17169327
FCGR2A PLCG2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7517665 8657103
C6 C7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17900710 10696521
FCGR1A PLCG2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7517665 8657103
H2BC12L H2AZ1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H2BC14 H2AC14 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H2BC14 H2AC4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H2BC13 H2AC4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H2BC15 H2AC4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H2BC12L H2AC4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H2BC11 H2AC4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1003064107 20498094
H2AC4 H2BC11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1003064107 20498094
H2AC12 H2BC12L â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H2BC12L H2AZ2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
MAPK14 MAPKAPK2 â—¼   PHOSPHORYLATION ✅ + 0.8 0.8 Signor 14499342
GTF2A1 GTF2H2 â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
GTF2B GTF2H2 â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
C8B C8G â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
CCND1 CDK1 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
ATF4 CREBBP â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
CDK1 CCNA1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 7799941 1628647 14681455 8565853 16009130
CDKN1A CCNE1 â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 16765349 5218735
EP300 CHD4 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 26546801 30110629 32699137 15189737
CCNA1 SKP2 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 16774918 19270695 17308064 10652300
TBPL1 GTF2A1 â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 24835508
CALM3 GRIN1 â—¼   PHYSICAL_INTERACTION 813.0 0.81 STRING 36370105
CALM2 GRIN1 â—¼   PHYSICAL_INTERACTION 813.0 0.81 STRING 36370105
C8B C9 â—¼   PHYSICAL_INTERACTION 816.0 0.81 STRING 36370105
EP300 ATF2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 10327051 24069158
FOSB ATF2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 32296183 33961781
BAD BAX â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 19427863 17274640
CDK2 CDK1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 21319273
ACTB EP300 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33742100 21988832
GTF2B GTF2H3 â—¼   PHYSICAL_INTERACTION 819.0 0.82 STRING 36370105
GNAI3 GNB2 â—¼   PHYSICAL_INTERACTION 819.0 0.82 STRING 36370105
DOK2 PLCG1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
SKP2 AKT1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 19270695 21358672 23911321 19270694
AKT3 AKT1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
FOSB CREB5 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 32296183 33961781
CALM3 CAMKK1 â—¼   PHYSICAL_INTERACTION 820.0 0.82 STRING 36370105
CALM2 CAMKK1 â—¼   PHYSICAL_INTERACTION 820.0 0.82 STRING 36370105
FPR2 GNAI1 â—¼   PHYSICAL_INTERACTION 823.0 0.82 STRING 36370105
AKT1 BAD â—¼   PHOSPHORYLATION ✅ - 0.82 0.82 Signor 9346240
KRAS MAPK1 â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
FPR2 GNB1 â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
GTF2A1L GTF2A2 â—¼   PHYSICAL_INTERACTION 825.0 0.82 STRING 36370105
CDC20 CDK1 â—¼   PHYSICAL_INTERACTION 826.0 0.82 STRING 36370105
CCND1 CDK1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 26496610 33961781 7903056 21654808
CCND3 CDK1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194 26496610
CCNE1 CDK1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 9053846 9891079 1388288
CCND3 CDK2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 16782892 33854235 26496610 9716181 33961781 26186194 23455922
CCNA2 EP300 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
CDC20 EP300 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 16319895
C1R C1QA â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 2372546 10878362
RAF1 LCK â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 16189514 8939988
SKP2 CDC20 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 26811472 25306918 20663873 33961781 15014502
CCNA2 CCNA1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
AKT1 CDKN1A â—¼   PHOSPHORYLATION ✅ + 0.83 0.83 Signor 31575057
AKT1 MAPK14 â—¼   PHYSICAL_INTERACTION 830.0 0.83 STRING 36370105
CASP1 GSDMD â—¼   PHYSICAL_INTERACTION 832.0 0.83 STRING 36370105
GNAI1 GNGT1 â—¼   PHYSICAL_INTERACTION 834.0 0.83 STRING 36370105
CCND1 EP300 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
CCND3 CDK1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
BRAF MAPK1 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
CREB5 ATF2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 8440710 28514442 26186194 33961781
CDK1 CDC20 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 28514442 10799291 26912231
CCNE1 CDK6 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 9716181 28628118 28205554
C1QC C1QB â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 21054788 16189514 12960167 28325905
AKT1 SKP2 â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
CCNE1 CDK4 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 9716181 28628118 28205554
AKT1 CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 0.84 0.84 Signor 18423396
CCNA1 SKP2 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
GNAI2 GNB4 â—¼   PHYSICAL_INTERACTION 844.0 0.84 STRING 36370105
CALM1 GRIN1 â—¼   PHYSICAL_INTERACTION 845.0 0.84 STRING 36370105
CDKN1A EP300 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
ATF2 MAPK11 â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
MAPK1 RAF1 â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
ARAF KRAS â—¼   PHYSICAL_INTERACTION 849.0 0.85 STRING 36370105
CDKN1B CDK1 â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 34591612
CDK1 SKP2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 28514442 26496610 33422522 33961781 26186194 32707033
CDKN1B CCNE1 â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 34591612
DOK2 LCK â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 10799545 16189514 25814554 15831486
HDAC3 AKT1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 29523594 20026773
CD86 CD28 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 27708164 21931534 11021528 7513726
AKT2 AKT1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 28514442 12149249 9736715 12176337 11445557 33961781 14500673 11278835 11546794
C8A C8B â—¼   PHYSICAL_INTERACTION 849.0 0.85 STRING 36370105
CCND1 CDKN2A â—¼   PHYSICAL_INTERACTION 850.0 0.85 STRING 36370105
CDK6 CDKN1B â—¼   PHOSPHORYLATION ✅ - 0.85 0.85 Signor 16160006
C8A C8G â—¼   PHYSICAL_INTERACTION 851.0 0.85 STRING 36370105
CALM1 CAMKK1 â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
GTF2E1 GTF2E2 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HuRI 32296183
LCK CDK1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 34079125 31980649
ATF4 EP300 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 14630807 17872950 10350644 12471036 16219772
AKT1 BRAF â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 10869359 25241761 28628118 28205554
CHEK1 DDB1 â—¼   PHYSICAL_INTERACTION 861.0 0.86 STRING 36370105
GNAI1 GNAI2 â—¼   PHYSICAL_INTERACTION 861.0 0.86 STRING 36370105
CCNA1 CDK1 â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
CDK1 SKP2 â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
ARAF RAF1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 31980649 34017080 20130576
CASP8 CASP3 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 15254227 11832478 18669646 11437602 8962078
CCND2 CDK2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 9840943 28514442 33854235 33961781 26186194 23455922 9178893
CDK2 CDC20 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 26811472 33961781 25852190 23455922
AKT1 EP300 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 21901101 15224190 21775285 20333651 18182168 11116148
HRAS BRAF â—¼   PHYSICAL_INTERACTION ✅ 0.87 0.87 mint 34591642
HRAS BRAF â—¼   PROXIMITY ✅ 0.87 0.87 mint 30194290
ARAF HRAS â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
CDK6 CDKN1A â—¼   PHOSPHORYLATION ✅ - 0.87 0.87 Signor 16508017
GNAI1 GNAI3 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
CASP8 TRAF2 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
GTF2A2 TBPL1 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
ATF2 CREB5 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
GTF2A1 GTF2H4 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
CDC20 SKP2 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
ARAF BRAF â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
GNAI2 GNG2 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
MAPK1 MAPK14 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
PIK3R2 PIK3R3 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
CD28 GRB2 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
BAD RAF1 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
AKT1 CDKN1B â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
ACTN1 ACTN4 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 22863883 22939629
EP300 CCND1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 15951563 10567390 11788592
SKP2 EP300 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 22770219 18243116 26593157
JAK1 GRB2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 11527382 8536716
CDK4 CDK6 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 23455922 28205554 28628118 33961781
CASP8 TRAF2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 23142077 22179575 17047155 28972304 12887920 16227629 21282461 11340079 30054040
BRAF RAF1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 23153539 28514442 31980649 18332145 20141835 23934108 31015455 11325826 23680146 20130576 26466569 22169110 33961781 34017080 28806393 20212043 25155755 22605333
AKT1 RAF1 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
CASP4 GSDMD â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
PSMC1 UBE3A â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
GNAI1 GNG4 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
AKT1 BAD â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
CCND2 CDKN1B â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
GNAI3 GNB4 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
AKT1 EP300 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
GNAI2 GNAI3 â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
LTBR TRAF2 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
RAF1 YWHAH â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
CDKN1B CCND1 â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 34591612
HDAC3 CCND1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 15713663 12048199 16461912 20484017 15558026
CDK1 CCNA2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 24302728 21308745 26496610 33422522 14681455 23602568 25852190 33961781 12853968 26186194 17679094 32707033 9053846 8463339 19483727
CREB1 EP300 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
CD28 GRB2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 9694876 27927989 7737275 7584133 8576157 24475931
CDK6 CDKN2B â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
C1QB C1QA â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 14681455 21054788 12960167
DLG1 LCK â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 25241761 9341123
HDAC3 HDAC9 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 12590135 10655483 11466315
CDC20 CCNA2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 27522463 19826003 23007648 19483727 18471975 26496610 25750436 25669885 19098431 26811472 10679238 25306918 32307883 20733051 31455778 26960431 33961781 32152539 26186194
SKP2 CCNE1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11237742 22959436 10790373
CDKN1A SKP2 â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
CREBBP GTF2B â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
CDK4 CDKN2B â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
CDK1 CDKN1B â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
HRAS KRAS â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
CDK6 CDKN1B â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
CCNA1 CDKN1B â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
BRAF ARAF â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 25241761 31980649 28628118 17979178 20130576 34017080 33961781 28205554
ATF2 CCNA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9511728 10777595 7843287
ATF2 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23800081 10506225
MAPK1 BAD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 8929531 10597268 12566304
BAK1 TRAF2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 22039431 23430059 23850759
AKT3 BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 14766748 15642728 17525161
CCND1 CDK2 â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
SKP2 CDK2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 16189514 9858587 9636170 25852190 23455922 10559858 19270695 26496610 23602568 16979657 10386600 19686743 15355997 20160477 18604603 22770219 33422522 33961781 26186194 7553852
CDK2 EP300 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 33961781 26186194 10330164 23455922
FGB CDKN1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
ACTB CDKN1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
GNB2 CDKN1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CDKN1A GNB5 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
EWSR1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12560328 18757425 20153576
TBPL1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22511763 8547219 24835508
CREB1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 25379405 14520699 21295542
CREB1 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19340300
EGR2 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19340300
CREB3 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19340300
FGA GRB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12005431 9566877 7997267
FGB GRB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12005431 9566877 7997267
FGG GRB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12005431 9566877 7997267
CDC42 GRB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
ITGA2B GRB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12005431 9566877 7997267
HLA-C GRB2 â—¼   DOWN_REGULATES ✅ - 3.0 0.9 ACSN 11513144 21339333 9605119
JAK1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8536716 11527382
GTF2H3 GTF2H2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8652557 15790571 10734072
HMGB1 TLR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23519706 20192808 16267105
IRF7 TLR7 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15361868 15767370 15492225
BRAF MAPK1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16508002 14654779 19933846
MAPK1 NCF4 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16778989 10400704 27558335
MAPK11 MAPK14 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
LCK MAPK14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24863062 15735648
MAPKAPK2 TRAF2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 28506461 28920952 28920954
H2AX ACTB â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
ATF4 EIF2AK2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23009153 21146245 17141186
CDK6 CCND2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 16713569 28628118 10022865 28205554 11360184 30217970 33961781 23602568 11358847 9178893
CALM3 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9859994 2550447 19608982
CALM1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9859994 2550447 19608982
C1R C1QA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10904115 15388251 761607
C1QC C1QA â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 14681455 21054788 12960167 28325905
C1QA C2 â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 6019133 12396008 10925294
C1QA C4A â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 15199963 14280442 12396008
CALM2 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9859994 2550447 19608982
CTSG C3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24315997 1861080
C1R C1QC â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10904115 15388251 761607
C1QC C1S â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10904115 15388251 761607
C1QC C2 â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 6019133 12396008 10925294
C1QC C4A â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 15199963 14280442 12396008
C1R C1QB â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10904115 15388251 761607
C1QB C1S â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10904115 15388251 761607
C1QB C4A â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 15199963 14280442 12396008
C1QB C2 â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 6019133 12396008 10925294
ADORA2A CD40LG â—¼   DOWN_REGULATES ✅ - 3.0 0.9 ACSN 17371980 17909080 18758473
LCK DOK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 25814554 10799545 16189514
LCK PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7682059 17570479 1500851
LCK RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7935389 8939988 16189514
FCGR3A PLCG1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 7517665 8657103 15161916
GNAS ADORA2A â—¼   PHYSICAL_INTERACTION 3.0 0.9 ACSN 17371980 17909080 18758473
GNAS ADORA2A â—¼   SHARES_COMPLEX 3.0 0.9 ACSN 17371980 17909080 18758473
GNB1 GNAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15782186 16189514 26186194
ADORA2A IFNG â—¼   DOWN_REGULATES ✅ - 3.0 0.9 ACSN 17371980 17909080 18758473
HLA-C IFNG â—¼   DOWN_REGULATES ✅ - 3.0 0.9 ACSN 11513144 21339333 9605119
AKT1 RAF1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 25241761 28628118 10576742 19197339 19058874 28205554
HDAC3 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16528103 18241676
CD28 CD80 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 2164219 7964482 21982860 1847722 7545666
SKP2 CCNA2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 9858587 26496610 27720894 33422522 16209941 33961781 24632684 15355997 26186194 7553852 31181401 20160477 10559858 33989513 18604603
CCNA2 SKP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9858587 15355997 33989513
SKP2 CCNA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9858587 15355997 33989513
CREB1 GRIN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22035109 14720206 15950782
GNGT2 GNB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8636150 19168127 19376773
HLA-DRA HLA-DQA1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 9312039 1956401 16618111
AKT2 BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10869359
PRKCB BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 1386920 17570479 12917261
C1S C1R â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 31749804 10092586 2387866 9477945 33961781 10878362 2372546 12788922 17996945
C1S C4A â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 15199963 14280442 12396008
C1R C2 â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 6019133 12396008 10925294
C1R C4A â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 15199963 14280442 12396008
FGB ITGA2B â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16040750 14754902 10446041
FGB PIK3R3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
PRKCG GRIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15936117 10862698
CASP4 CASP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12843244 9491891 9039262
MAPK7 ELK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10473620
C5 C6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 1387399 2808363
C8A C9 â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
C8A C9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10346902 3624872 4063341
PRKCB NCF4 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 12056906 27558335 19372727
PRKCB C5AR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17145764
FCGR3A PLCG2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 7517665 8657103 15161916
C4A CR1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10531307 11694537 293688
CDK6 CDKN1A â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
CCNA2 SKP2 â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
GTF2A1 GTF2E1 â—¼   PHYSICAL_INTERACTION 902.0 0.9 STRING 36370105
CCND2 CDK2 â—¼   PHYSICAL_INTERACTION 903.0 0.9 STRING 36370105
CCND3 CDK2 â—¼   PHYSICAL_INTERACTION 904.0 0.9 STRING 36370105
ACTB ACTG1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HuRI 32296183
GTF2A2 GTF2E2 â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
GTF2A2 GTF2H4 â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
C1QB C1QC â—¼   PHYSICAL_INTERACTION 907.0 0.9 STRING 36370105
CCND3 CDKN1B â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
GNAI1 GNB4 â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
CDK1 CDKN1A â—¼   PHYSICAL_INTERACTION 909.0 0.91 STRING 36370105
MAPK1 MAPKAPK2 â—¼   PHYSICAL_INTERACTION 909.0 0.91 STRING 36370105
CCND2 CDKN1A â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
CDK2 SKP2 â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
CDC20 CDK2 â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
CCND1 CDK6 â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
YWHAH RAF1 â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 8005785 11697890
CCNE1 CDK1 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
CCNA2 CDKN1A â—¼   PHYSICAL_INTERACTION 921.0 0.92 STRING 36370105
CDK4 CDKN2A â—¼   PHYSICAL_INTERACTION 922.0 0.92 STRING 36370105
GTF2A2 GTF2E1 â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
CCNA1 CDKN1A â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
CDKN1B SKP2 â—¼   PHYSICAL_INTERACTION 928.0 0.92 STRING 36370105
GTF2B GTF2H4 â—¼   PHYSICAL_INTERACTION 928.0 0.92 STRING 36370105
CCNA2 CDK1 â—¼   PHYSICAL_INTERACTION 929.0 0.93 STRING 36370105
CDKN1B CDK4 â—¼   PHYSICAL_INTERACTION ✅ 0.93 0.93 mint 5219242 17053782
CDC20 CCNA1 â—¼   PROTEIN_INTERACTION 0.93 0.93 HIPPIE 19477924 10679238
CCND3 CDKN1A â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
GTF2A1 GTF2E2 â—¼   PHYSICAL_INTERACTION 931.0 0.93 STRING 36370105
GNB3 GNGT1 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
GNB5 GNGT1 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
GNB2 GNGT1 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
CD40 CD40LG â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
GNB5 GNG5 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
GNB3 GNG11 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
GNB3 GNGT2 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
GNB4 GNGT2 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
CCNA1 CDK2 â—¼   PHYSICAL_INTERACTION 933.0 0.93 STRING 36370105
BRAF KRAS â—¼   PHYSICAL_INTERACTION 933.0 0.93 STRING 36370105
BRAF RAF1 â—¼   PHYSICAL_INTERACTION 935.0 0.93 STRING 36370105
CCNE2 CDKN1B â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
CCND2 CDK6 â—¼   PHYSICAL_INTERACTION 939.0 0.94 STRING 36370105
GNAI2 GNAI3 â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 28514442 22939629 33961781 26186194
GNAI1 GNAI3 â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 28514442 22939629 33961781 26186194
ATF2 MAPK14 â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
GTF2A1 GTF2B â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
HLA-DMA HLA-DRA â—¼   PHYSICAL_INTERACTION 945.0 0.94 STRING 36370105
C6 C8G â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
C6 C8B â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
C6 C9 â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
C6 C8A â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
C6 C7 â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
GTF2B GTF2E1 â—¼   PHYSICAL_INTERACTION 948.0 0.94 STRING 36370105
CDKN1A CCND2 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 16765349 5218735
GTF2B GTF2E2 â—¼   PHYSICAL_INTERACTION 949.0 0.95 STRING 36370105
ACTG1 ACTB â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 8153045 21516116
CCND2 CDK4 â—¼   PHYSICAL_INTERACTION 949.0 0.95 STRING 36370105
ACTN1 ACTN4 â—¼   PHYSICAL_INTERACTION 952.0 0.95 STRING 36370105
CDK2 CDKN1B â—¼   PHOSPHORYLATION ✅ - 0.95 0.95 Signor 17409098
CCNE2 CDKN1A â—¼   PHYSICAL_INTERACTION 954.0 0.95 STRING 36370105
GTF2E2 GTF2H3 â—¼   PHYSICAL_INTERACTION 954.0 0.95 STRING 36370105
GTF2E1 GTF2H3 â—¼   PHYSICAL_INTERACTION 954.0 0.95 STRING 36370105
C3 CR1 â—¼   PHYSICAL_INTERACTION 955.0 0.95 STRING 36370105
GNAS GNG2 â—¼   PHYSICAL_INTERACTION 955.0 0.95 STRING 36370105
GTF2E2 GTF2H2 â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
GTF2E1 GTF2H2 â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
BRAF HRAS â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
GTF2A2 GTF2B â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
CDK2 CDKN1A â—¼   PHOSPHORYLATION ✅ - 0.95 0.95 Signor 15964852
CCND3 CDK6 â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
C5 C8G â—¼   PHYSICAL_INTERACTION 958.0 0.95 STRING 36370105
AKT1 BAD â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 15998799 10358075 25241761 11500364 9381178 11994280 23085457 15722337 19667065 15784622
CCND1 CDK2 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 9840943 28514442 8647086 33854235 8479754 26496610 33854239 33961781 23455922 21654808 9178893
CDK2 CCNE1 â—¼   PHOSPHORYLATION ✅ - 0.96 0.96 Signor 19561641
CCNE1 CDKN1B â—¼   PHYSICAL_INTERACTION 959.0 0.96 STRING 36370105
CDKN1B CCNA2 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 34591612
CREB1 EP300 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 12665587 21268077 10506141 21212407 11313407 7870179 17476304 22787115 26944191 33846793
PLCG1 GRB2 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 16713569 7629168 7516467 9020117 21706016 10940929 16038803 9281317
RAF1 BRAF â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 8396417 22510884
C1QA C1QC â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
C5 C8A â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
C5 C9 â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
CCNE1 CDKN1A â—¼   PHYSICAL_INTERACTION 964.0 0.96 STRING 36370105
FGB FGG â—¼   PHYSICAL_INTERACTION 964.0 0.96 STRING 36370105
C1QA C1QB â—¼   PHYSICAL_INTERACTION 967.0 0.96 STRING 36370105
CDK6 CCND1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 15232106 16713569 10022865 24855949 17517622 33854235 11739795 14681455 24953629 11360184 33961781 10580009 17420273 21654808 11160398 9178893 19075005
CCNE2 CDK2 â—¼   PHYSICAL_INTERACTION 969.0 0.97 STRING 36370105
CDKN1B CDK2 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 34591612
CCNE2 CDK2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 15232106 9840943 28514442 24358021 9858585 26496610 14681455 25852190 9840927 33961781 26186194 23602568 23455922
CDK6 CCND3 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 8153045 21516116
CDK6 CCND3 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 16189514 25416956 33854235 14681455 21516116 32296183 17517622 9716181 11360184 30217970 23602568 15232106 26264872 27107012 32707033 16782892 16713569 8114739 29997244 32814053 33961781 26186194
CDKN2B CDK4 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 21900206 2001699 8089645
GTF2A1 TBPL1 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
KRAS RAF1 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
C1R C1S â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
C5 C6 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
C5 C7 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
GNAS GNB1 â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
CDK2 CCNA2 â—¼   PHOSPHORYLATION ✅ + 0.97 0.97 Signor 10652300
C5 C8B â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
CD40 TRAF2 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
CDKN1A CDK2 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 16765349 5218735
HRAS RAF1 â—¼   PROXIMITY ✅ 0.98 0.98 mint 18273062 6540139
RAF1 HRAS â—¼   PROXIMITY ✅ 0.98 0.98 mint 18273062 6540139
CCNA2 CDC20 â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
CDK4 CCND3 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 8153045 21516116
CDK6 CDKN2A â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
GNAI1 GNG2 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
CCND1 CDKN1A â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
CDK4 CDKN1B â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
CREB1 CREBBP â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
CCND1 CDKN1B â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
CDK4 CDKN1A â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
CCNA2 CDKN1B â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
GTF2E2 GTF2H4 â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
FGA FGB â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
FGA FGG â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
GNAI2 GNB1 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
CCND1 CDK4 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 28514442 25416956 25241761 8259215 9372967 29142209 9150368 18537972 16431923 33854235 24292678 9178893 33854239 9106657 14681455 8867812 8662825 17420273 19767775 16985050 19075005 12519773 21306487 26203195 24855949 23007395 11360184 10580009 11463845 17081987 8978686 16613857 15681588 21242975 15232106 9837900 24218572 27130439 10022865 25910212 9228064 12036906 23707388 23543736 27107012 23718855 19470470 31217276 10908655 8756624 25502805 17205132 33961781 20837141 19237565 21654808 11160398 7568034
CCNA2 CDK2 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 8475101 28514442 16431923 33854235 11940657 10559988 15189033 17361108 16290148 14681455 17254966 8662825 25852190 15557281 23455922 19483727 18471975 11141566 10924145 15828833 21241890 19631451 11377199 18177895 8684460 26496610 9716181 12853968 11907280 23602568 9724724 15647383 14656438 19773423 12941338 15239650 24302728 25669885 15890360 7630397 8756328 8397207 21447625 22231403 20733051 9660939 24358021 12044161 33422522 11983168 33961781 26186194 7553852 16209941 12244298 9380407 8463339 15455144 10930425
CDK2 CCNE1 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 28514442 28137908 16431923 29439025 9891079 18559665 33854235 11940657 15004009 17431037 17361108 33854239 14681455 17254967 8867812 23853094 10827081 10330164 8662825 25852190 15557281 9192873 23455922 21092281 14536078 21372285 21241890 19631451 16223725 26496610 1388288 9716181 9472014 15980415 14701826 23602568 8978686 11433299 11132966 24771265 12839982 20587660 19470470 10359664 15514162 17970072 9840943 25728284 9660939 8647086 24358021 7799941 12529437 8756624 33961781 15670215 26186194 20837141 12800980
GTF2E2 GTF2H1 â—¼   PHYSICAL_INTERACTION 989.0 0.99 STRING 36370105
CCND2 CDK4 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 28514442 16189514 14681455 32296183 9325318 11360184 30217970 28205554 15169570 10022865 17873913 25910212 27107012 28628118 33961781 26186194 11896535 9178893 11971966
CCND3 CDK4 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 28514442 16189514 25416956 21988832 33854235 9106657 14681455 21516116 23880157 16985050 32296183 10342870 26496610 19237555 9716181 11360184 30217970 15232106 14641107 25910212 27107012 16782892 33961781 26186194 11896535
GTF2E1 GTF2H4 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
MAPK14 MAPKAPK2 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
GNAI3 GNB1 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
CCND3 CDK4 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
GRIN1 GRIN2B â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
GNB3 GNG13 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB1 GNG13 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB3 GNG10 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB1 GNG10 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB2 GNG10 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB5 GNG7 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB5 GNG3 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB5 GNG4 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB5 GNG2 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB3 GNG4 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB3 GNG12 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB3 GNG5 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB3 GNG3 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB3 GNG7 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB4 GNG7 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB4 GNG4 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB4 GNG3 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB4 GNG5 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB2 GNG7 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB2 GNG5 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB2 GNGT2 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB2 GNG12 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB2 GNG3 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB2 GNG4 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB1 GNG4 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB1 GNG3 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB1 GNG11 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB1 GNG5 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB1 GNG7 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB1 GNGT2 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB1 GNG12 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GTF2A1 GTF2A2 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GTF2E1 GTF2H1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
CCND1 CDK4 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CDK2 CDKN1B â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CDK2 CDKN1A â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
GTF2H1 GTF2H3 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
GTF2H1 GTF2H4 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
GTF2H3 GTF2H4 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
GNB1 GNGT1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
GNB2 GNG2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
GNB3 GNG2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
GNB4 GNG2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
GNAI1 GNB1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
GRIN1 GRIN2A â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
KRAS ARAF â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 24937142 16537381 16364920 19727074 11325826 16508002 23360980 15467451 23993095 15258589
HRAS ARAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17145710 12620389 24441586 21779497 10545207
ATF2 RAF1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 11274345 12738796 18039929 20506250
ATF2 GRB2 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 11274345 12738796 18039929 20506250
ATF2 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 9990041 10915780 11850817 11410592 11739785 15691880 16405968 10464245 10500157 15314161 10066798
ATF2 IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18641343 12836278 20006311 20304822
MAPK1 ATF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 10777545 17081983 21098032 9430721 12110590 20068231 19690332 15304344 19413330 10878576 15192015 7737129 18669648 19647037
MAPK14 ATF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 104.0 1.0 Omnipath 17081983 18767875 21098032 20506250 26359454 19690332 11060298 19413330 12788955 10085140 22037767 11566021 17079470 19647037 10581204 10777545 7535770 23331499 7839144 19324872 21071413 21614932 20068231 16393692 15304344 17570479 17380123 18988627 7737130 18669648 15187187 9305639 7737129 15140942 602896 11896587 17548358 12110590 7824938 8663524 33893075 12024021 11078583 11971971 9707433 17258390 10821277 19651622 19436832 11259586 27726305 11781825 9430721 27142525 10909971 12118074 15569672 15212693 9753474 11274345 10903740 26987986
MAPK11 ATF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 17145710 17081983 20506250 19690332 19413330 17079470 11566021 10085140 17254968 10777545 7535770 7839144 21614932 16393692 15304344 17380123 7737130 15192015 18669648 15187187 15140942 9235954 12110590 17258390 19436832 9155018 9430721 9029150 14734562 11274345
AKT1 BAD â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 10722653 10949026 11715018 11756412 11923280 15169778 15808505 16697215 17052453 17680028 18372248 18570873 18636226 20138985 20214616 20398329 20832730 9812896
CDK1 BAD â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 12049737 14551205 15279786 17303408 17660363 18414028 18590585 21725609 7575488
RAF1 BAD â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 11532940 12107820 12566895 14764585 15516985 19289794 19565474 24027568 8929532 9069260
CDK1 BAD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 18071308 16166315 24677263 12965220 15907327 26287183 21858202 25618528 12049737 16009721 19124971 16403219 17498878
RAF1 BAD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 38.0 1.0 Omnipath 11983683 12444011 10880354 19030972 19667065 22096607 15849194 16931767 17535812 16103085 9381178 23162742 12107820 18402774 12767520 10826997 8929532 8929531 12175651 25241761 19565474 10949026 19165420 9069260 21540285 17242355 23397142 19289794
YWHAH BAD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 21988832 11697890 8929531 9369453 17979178
AKT3 BAD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 26.0 1.0 Omnipath 9346240 11493700 20398329 21506126 9381178 20028971 12040186 21303971 15280015 20214616 10230394 10558990 8929531 10837486 11882383 10611223 23109003 12954615 22094462 10949026 15023346 17680028 18218901 17270021
AKT1 BAD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 137.0 1.0 Omnipath 10880354 19052636 21506126 20028971 21303971 20214616 11994280 8929531 17570479 12832477 17555943 25241761 11715018 18636226 21998731 9812896 17680028 11500364 18385666 18707149 10201527 18218901 11983683 10490655 19030972 19667065 11756412 11020382 16931767 18372248 15808505 20138985 18046313 18669648 19121340 19703413 11714830 10949026 15972258 16341064 10358075 23085457 18220336 10516287 12897128 9580112 9651683 11923280 9346240 16697215 19690332 11493700 15452053 12040186 10826997 12175651 15722337 14737178 11882383 15226424 10521512 15023346 15784622 17052453 16044149 16403219 12444011 20166139 20398329 9381178 11544290 15037618 12767520 15280015 10230394 10558990 15998799 10082559 11577096 10837486 15169778 10611223 23109003 12954615 22094462 11438654 11312610 11254732 21540285 10383455 19664994 10722653 20832730 18570873 10926925 17270021
AKT2 BAD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 27.0 1.0 Omnipath 9346240 11493700 20398329 21506126 9381178 15452053 20028971 12040186 21303971 15280015 20214616 10230394 10558990 8929531 10837486 11882383 10611223 12954615 22094462 10949026 11438654 17680028 10516287 18218901 17270021
BAK1 BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15901672 11571294 16189514 16439990
BAX TRAF2 â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 20709625 21641962 22039431 23064052 23377657 23430059 23850759 26587781 7644501 8358790
BAX TRAF2 â—¼   PROTEIN_INTERACTION 10.0 1.0 ACSN 20709625 21641962 22039431 23064052 23377657 23430059 23850759 26587781 7644501 8358790
BAX TRAF2 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 20709625 21641962 22039431 23064052 23377657 23430059 23850759 26587781 7644501 8358790
AKT1 BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 26763134 14766748 15642728 17525161
MAPK14 CASP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 14970175 33176141 29414778
CASP8 CASP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 15755874 17179148 9501089 9950028 18669646 23308069 10988287 18458084 16964285 9885230 9765224 11437602 15014070 21295084 8962078 9208847
CASP3 GSN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 9323209 9930654 9671712
CASP3 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 25241761 9660939 10022118 9799125
CASP3 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 17544405 12124386 10579725
CREB1 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 23447091 16503642 18957421 9990041 12504100 10915780 15116100 22271686 14764597 16522741 18713830 24065533 10201372 22751440 18988190 12391146
EP300 CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 17306568 17666529 11788592 23343194 21285352 15576399 21151179 22761862 22290435 16039586 19619488 19623618 17143292
CDKN1B CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 17145710 9106657 10908655 17254966 25416956 7478582
CDKN1A CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 31.0 1.0 Omnipath 26203195 23443559 17145710 25416956 7478582 9837900 21988832 21516116 7777546 15232106 16082198 27107012 15695403 8657154 8242751 23007395 9106657 12383116 17556661 8756624 8662825 31515488
CCND1 CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 63.0 1.0 Omnipath 26203195 17145710 8978686 12036906 23562856 25416956 16985050 23707388 19767775 9837900 17517622 19237565 9372967 25502805 23718855 9228064 7736585 15232106 11360184 20837141 21306487 25910212 25241761 27107012 9150368 18537972 9178893 31217276 8867812 10580009 23007395 11160398 19470470 19075005 9106657 8259215 10908655 8756624 23543736 24855949 7568034 24218572 8662825 31515488 17205132
CCND1 CDK6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 19075005 17517622 9178893 11739795 24855949 15232106 16713569 11360184 10580009 11160398
CDK1 CDC20 â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 12124778 14551205 14614141 15242590 15279786 15375219 15377654 15485915 15917306 16713580 16818604 17303408 17596790 17660363 18414028 18543256 18590585 18995830 19652693 19686080 7575488 9892021
CCNA2 CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17145710 1833185 10924145 8423786
CDKN1A CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 9467962 26186194 21308745 15340381 23602568 23543736 24218572 17679094 15077146 26496610 12973835
EIF2AK2 CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 25149538 20395957
CDK1 CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20937773
CDK1 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 23455152 23543736 25032860 21490307 16492801 10931950
CDK1 CHEK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 20798862 19837665 18691976 21765472 21907702 29092815 18983824 16629900 22686412 24242917
CDK1 SLBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 18490441 23286197 12588979 27773672
CDK1 DDX3X â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 16280325 17379183
CCNE1 CDK2 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
CCNA2 CDK2 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
CCNA1 CDK2 â—¼   PROTEIN_INTERACTION 1.0 1.0 HIPPIE 16189514 15583032 25241761 16777603 10559988 14681455 9636170 16159883 9041194 10652300 8565853 12970441 14701826 8397206 14681231 11264176 8397207 15601848 12191604 12190313 7799941 19423708 12800980 16009130
CDK2 CDKN2A â—¼   DOWN_REGULATES ✅ - 32.0 1.0 ACSN 11274345 11283614 12545156 14536078 15147722 15155580 15279786 17055429 17303408 17550342 17558397 17660363 17873522 18590585 18636226 20027199 20237412 20551172 20581311 20713526 20818389 21406394 21733352 2191300 21919891 22067385 23140366 23869868 25002027 28536364 7575488 9618481
MAPK1 CDK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10962581 12359725
AKT1 CDK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18354084 29665367
CDK2 SKP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 7553852 20160477 23602568 25271736 18239684 28446188 23226679 10386600 19270695 26496610 16189514 25852190 26186194 25788262 9858587 22770219 15355997 10559858 23807222 22311674 16979657 9636170 19686743 19270694 18604603 23455922
CDK2 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 94.0 1.0 Omnipath 23443559 23455922 10878006 20100570 23602568 15964852 20839231 25416956 23737759 9840943 18850315 11302688 20519948 24358021 19440234 15557281 9472014 9658399 16962592 9736735 12949733 8641969 10022118 15890360 12839982 16765349 17418410 15647383 10874474 15232106 17570479 17698606 12361598 26496610 9632134 24419005 12417722 16189514 26186194 20587660 25241761 8622677 9660939 25483090 12800980 20102411 10918595 12058028 12144826 8242751 9464540 9858587 29899857 23007395 11477082 9218599 12383116 25463440 12730199 8756624 9284049 9380407 9546435 24218572 16964243 15212693 13678583
CDK2 CCNA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 81.0 1.0 Omnipath 8756328 7553852 11377199 17145710 23602568 11983168 12044161 19483727 12853968 16209941 8397207 15455144 19631451 8475101 24358021 15557281 8684460 12941338 15647383 15890360 21447625 9380407 26496610 11141566 25852190 15189033 14656438 20733051 21241890 10652300 25669885 12244298 26186194 10930425 9660939 10477583 24302728 15239650 19773423 8463339 16290148 10924145 11907280 17361108 17254966 8662825 15828833 18471975 9724724 7630397 10559988 9716181 11940657 23455922
CDK2 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 125.0 1.0 Omnipath 26416244 20519948 19631451 16326706 17409098 15557281 9658399 23029392 22733130 17570479 26496610 23576547 12700233 9388487 10585280 27282251 27175940 15619620 25241761 15735731 9218599 9192873 17254966 15996662 9724724 11940657 18285702 22492278 23409140 18615582 12093740 22721951 15647383 9380407 17418410 16189514 17053782 17698606 25852190 10679394 17602833 9660939 12188931 15122251 10831586 25818643 22028818 21424700 12529437 15011833 12042314 11250701 11223033 23455922 8978686 16780593 21439954 15302935 19648963 14504289 9736735 10198259 16782892 11565035 21423803 16492801 9311993 12417722 17671428 21187893 15355997 28601655 10809788 10393546 15212693 10323868 26450989 23602568 18850315 12482975 9399644 15890360 9632134 17254967 26186194 20810788 20197382 15475007 12800980 17997402 12972555 15980415 24336329 26701207 25605247 26987798
CDK2 CHEK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 21765472 21965652 21907702 18983824 24242917
CDK2 CCNE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 50.0 1.0 Omnipath 17145710 16223725 21092281 15004009 10962581 9840943 8643455 24358021 8861947 21372285 17570479 11237742 10330164 22558078 10652300 19561641 10477583 18691976 23853094 12144826 10500095 1388288 10827081 17970072 28137908 19470470 8756624 10809788 14536078 15364936
CDK2 DLG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19066288
CDKN1A CDK6 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 14517297 17092340 9106657 18710949 24515438 20843055
EP300 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10362258 15509808 21858218 22000024 21245169
SKP2 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 32035614 25241761 23261596 17679094 15998794 17477906 19686743 16376880 15980415 18794347 13678583
AKT3 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 12851486 15023346 19216069 17680028 11756412 16680151 20214616 11463845 23109003 20452955 9829964 20398329 17646672 10217147
AKT2 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 19216069 17680028 11756412 16680151 20214616 11463845 21933447 16982699 20452955 9829964 20398329 17646672 10217147
MAPK1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 20519948 19364816 28368408
HDAC3 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9618481 17550342 12545156 15155580 22796940 22370643 16533812 17508028
CDK6 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 25121590 20102411 15964852 22375140 15232106 16713569 16508017 19440234
AKT1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 74.0 1.0 Omnipath 11756412 11923280 16697215 20452955 27603133 20398329 18372248 15001356 15808505 10217147 19440234 20138985 12431783 10753973 17855660 19216069 28358423 20214616 11463845 9829964 17570479 17646672 16680151 11231573 15169778 12851486 31575057 25241761 23109003 21933447 10949026 16775416 23886938 26436589 16288292 11715018 16055744 18636226 15023346 9812896 12042314 17680028 24848107 16982699 11779850 10722653 20832730 18570873 20307683 34069970 17052453 15798220
MAPK14 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23745637 12058028
CDKN1A CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 23443559 26186194 25241761 27107012 8756624 15169570 25416956 16765349 31515488 16189514 32296183
CDKN1A CCNA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 12383116 25241761 8756624 29997244 16982699 7478582 10022926 32814053 15232106 16009130 16189514
CDKN1A CCND3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 22.0 1.0 Omnipath 21988832 23443559 26186194 25241761 27107012 8756624 25416956 16328436 31515488 16189514 15232106 32296183 23880157 26496610 9716181
CDKN1A CCNA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 23443559 26186194 21308745 9660939 8756624 15890360 9380407 8242751 8662825 12947099 9632134 17679094 26496610
CDKN1A CCNE2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 17145710 23443559 26186194 28514442 9840927 9840943 15232106 26496610 24358021
CDKN1A CCNE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 17145710 23443559 31831640 21988832 9472014 17293600 11438644 9380407 12839982 16765349 9632134 25241761 8891332 9660939 8242751 9218599 11477082 8756624 8662825 8637717 9716181 13678583
CDKN1A CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 27.0 1.0 Omnipath 23443559 15169570 18850315 9658399 16962592 15232106 9632134 16189514 8622677 15695403 20102411 8242751 9464540 23007395 7626805 9106657 12383116 30193583 17556661 23543736 8756624
YWHAH CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 14504289 12042314
AKT2 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12244303 18593906
CCNE1 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 17145710 31831640 8978686 8684460 17293600 9632134 17254967 9311993 20837141 27175940 9488039 25241761 8891332 9660939 7753174 19470470 9218599 12529437 9192873 8756624 17254966 12501191 9891079 10393546 9716181 11940657
MAPK1 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 12042314 9192873 10831586 10931950 12700233 15212693 15735731
CDK6 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 16160006 25241761 18615582 16782892 21439954 11360184
CCNE2 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17254966 9840927 9858585 9840943
SKP2 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 47.0 1.0 Omnipath 26450989 20160477 12820959 18805092 16209941 24085301 11565034 15071497 18239684 22959436 17409098 22524983 15147722 12529174 23910095 15998794 16189514 22310285 35247157 12813041 21503567 20663873 22632967 10559916 11516665 11463388 12140288 15688063 15469821 20160482 15735731 15355997 15340381 12042314 15075339 21237244 19686743 32265224
AKT1 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 69.0 1.0 Omnipath 22119715 11756412 16780593 11923280 16697215 16209941 12244303 20398329 18372248 14967450 18710949 15808505 26053093 20138985 14504289 20214616 12244302 17570479 18593906 23576547 23400686 12851486 15169778 24651496 19829074 25241761 10949026 16288292 11715018 18636226 19377290 9812896 12042314 17680028 10722653 20832730 18570873 12244301 17052453
CDKN1B CCNA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 15583032 29997244 7478582 10022926 18692475 32814053 16189514
CDKN1B CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 25910212 16189514
CDKN1B CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 35.0 1.0 Omnipath 23602568 8978686 23707388 21439954 18850315 16326706 9658399 14597415 18615582 10198259 16782892 9632134 16189514 17053782 11360184 9311993 17092340 20837141 26186194 25241761 15695403 9464540 19470470 9106657 10908655 23543736 11940657 18285702
CDKN1B CCNA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 17145710 8684460 26186194 9660939 17254966 15890360 16209941 12947099 12501191 26496610 9724724 9311993 9716181
CDKN1B CCNE2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17254966 9840927 9858585 9840943
CDKN1B CCND3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 14597415 16189514 10342870 16328436
CDKN1B CCNE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 29.0 1.0 Omnipath 17145710 31831640 8978686 8684460 17293600 9632134 17254967 9311993 20837141 27175940 9488039 25241761 8891332 9660939 7753174 19470470 9218599 12529437 9192873 8756624 17254966 12501191 9891079 10393546 9716181 11940657
EP300 CDKN2A â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 32284348 19273602 32601262 10821856 28985506 33043019 31597407
CDKN2A CREBBP â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 32284348 19273602 32601262 10821856 28985506 33043019 31597407
HRAS CDKN2A â—¼   UP_REGULATES ✅ + 15.0 1.0 ACSN 10358164 12134164 12447393 14764585 16102570 17673906 20841469 24027568 24954210 7510700 7673236 8551221 9069260 9763606 9846483
CDKN2A CDK6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 17881001 26186194 23602568 9751050 11739795 11556834 9380698 15232106 16713569 17955473 10491434 16915296 17909018
CDKN2A CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 37.0 1.0 Omnipath 17145710 11900540 23602568 9529249 11556834 16161044 17881001 17517622 15065884 9228064 15232106 26496610 10585280 17909018 26186194 17353931 10580009 17955473 10491434 12529334 10719365 28042499 8259215 24855949 8891723 23455922
AKT1 CHEK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 20832017 18691976 23108403 17418864 20068231 12062056 15107605 17570479 19664995 18669648 26091525
IFNG EP300 â—¼   ENZYMATIC_REACTION ✅ 31.0 1.0 ACSN 10485906 11489965 11579131 11777960 11870632 11964313 12413632 12818165 14607900 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 1825141 18272812 19833085 20038811 20819927 21149606 21411734 24658051 26755705 2965306 6425450 9834059 9864217
AKT2 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17964260 16926151
AKT1 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 17623675 18182168 16926151 20333651 19158375 17964260 17570479 11116148 25904863 21901101 23275565 16024795
MAPK1 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17623675 24530506
EP300 CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17306568 17666529 23343194 21285352 15576399 21151179 22761862 22290435 16039586 19619488 19623618 17143292
GRB2 BRAF â—¼   PHYSICAL_INTERACTION 48.0 1.0 ACSN 10086337 10567412 10811803 10843677 10982827 11023813 11034387 11062502 11385609 11447289 11777939 11907067 12040186 12175651 12419216 12640133 12782630 14585353 14764585 15169888 15536084 15547943 15567848 15574420 15735649 15863030 16102570 16227978 16488589 16582911 16887996 17178906 17395718 17496910 17613518 17673906 19449109 19541618 19565474 19568798 19615955 21102635 22435554 24027568 26552706 7510700 8551221 9510155
GRB2 RAF1 â—¼   PHYSICAL_INTERACTION 54.0 1.0 ACSN 10086337 10567412 10811803 10843677 10982827 11034387 11062502 11385609 11447289 11532940 11777939 11907067 12040186 12175651 12419216 12479806 12566895 12640133 12782630 14585353 14764585 15169888 15516985 15536084 15547943 15567848 15574420 15735649 15863030 16102570 16227978 16488589 16582911 16887996 17178906 17395718 17496910 17673906 18039929 19289794 19449109 19541618 19565474 19568798 19615955 21102635 22435554 24027568 26552706 7510700 8551221 8929532 9069260 9510155
GRB2 CD28 â—¼   PHYSICAL_INTERACTION 23.0 1.0 ACSN 10086337 10209041 10567412 10811803 10982827 11447289 11777939 12175651 12640133 1313950 15197224 15567848 15574420 16582911 16887996 17496910 17673906 19449109 22437870 26552706 7523569 8551221 9359474
GRB2 PLCG1 â—¼   PHYSICAL_INTERACTION 51.0 1.0 ACSN 10072481 10086337 10209041 10567412 10781611 10811803 10925299 10982827 11169415 11447289 11532940 11777939 11994416 12175651 12640133 1281218 12845332 14764585 15214048 15567848 15574420 16102570 16329184 16582911 16887996 1712101 17397400 17496910 17673906 19449109 19494291 19909365 23523669 23620508 24584707 25137453 2536067 25456276 25960930 26552706 7523143 7682895 7890616 8226994 8551221 8649391 8976179 8995379 9489702 9535722 9846483
GRB2 PLCG1 â—¼   SHARES_COMPLEX 51.0 1.0 ACSN 10072481 10086337 10209041 10567412 10781611 10811803 10925299 10982827 11169415 11447289 11532940 11777939 11994416 12175651 12640133 1281218 12845332 14764585 15214048 15567848 15574420 16102570 16329184 16582911 16887996 1712101 17397400 17496910 17673906 19449109 19494291 19909365 23523669 23620508 24584707 25137453 2536067 25456276 25960930 26552706 7523143 7682895 7890616 8226994 8551221 8649391 8976179 8995379 9489702 9535722 9846483
GRB2 CD28 â—¼   SHARES_COMPLEX 23.0 1.0 ACSN 10086337 10209041 10567412 10811803 10982827 11447289 11777939 12175651 12640133 1313950 15197224 15567848 15574420 16582911 16887996 17496910 17673906 19449109 22437870 26552706 7523569 8551221 9359474
GRB2 BRAF â—¼   SHARES_COMPLEX 48.0 1.0 ACSN 10086337 10567412 10811803 10843677 10982827 11023813 11034387 11062502 11385609 11447289 11777939 11907067 12040186 12175651 12419216 12640133 12782630 14585353 14764585 15169888 15536084 15547943 15567848 15574420 15735649 15863030 16102570 16227978 16488589 16582911 16887996 17178906 17395718 17496910 17613518 17673906 19449109 19541618 19565474 19568798 19615955 21102635 22435554 24027568 26552706 7510700 8551221 9510155
GRB2 RAF1 â—¼   SHARES_COMPLEX 54.0 1.0 ACSN 10086337 10567412 10811803 10843677 10982827 11034387 11062502 11385609 11447289 11532940 11777939 11907067 12040186 12175651 12419216 12479806 12566895 12640133 12782630 14585353 14764585 15169888 15516985 15536084 15547943 15567848 15574420 15735649 15863030 16102570 16227978 16488589 16582911 16887996 17178906 17395718 17496910 17673906 18039929 19289794 19449109 19541618 19565474 19568798 19615955 21102635 22435554 24027568 26552706 7510700 8551221 8929532 9069260 9510155
HRAS GRB2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
KRAS GRB2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
LCK GRB2 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 10652356 11062502 12731048 12740575 15536084 17544292 19290918 20814939 21127503 22513334 23620508 8478617 8986721 9438848 9738502 9751747
GRB2 PLCG2 â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10072481 10086337 10567412 10781611 10811803 10982827 11169415 11447289 11777939 12175651 12640133 14764585 15567848 15574420 16102570 16329184 16582911 16887996 17496910 17673906 19449109 19494291 19909365 23620508 25137453 26552706 7523143 7890616 8551221 8649391 8976179 9489702 9535722
GRB2 PLCG1 â—¼   ENZYMATIC_REACTION ✅ 51.0 1.0 ACSN 10072481 10086337 10209041 10567412 10781611 10811803 10925299 10982827 11169415 11447289 11532940 11777939 11994416 12175651 12640133 1281218 12845332 14764585 15214048 15567848 15574420 16102570 16329184 16582911 16887996 1712101 17397400 17496910 17673906 19449109 19494291 19909365 23523669 23620508 24584707 25137453 2536067 25456276 25960930 26552706 7523143 7682895 7890616 8226994 8551221 8649391 8976179 8995379 9489702 9535722 9846483
CD28 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 18829987 8576157 9694876 24098653 27927989 21487479 7737275
GRB2 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 9281317 15953601 7629168 9020117 16713569 10940929
GRB2 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17496910 16713569 17673906 11352655
GSN ACTG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11733011 7849017 15526166
GTF2H1 GTF2H2 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
GTF2H1 GTF2H2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 21988832 10734072 11062469 9130708 8652557 8194529
GTF2H2 GTF2H4 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
GTF2H2 GTF2H3 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
IFNG HMGB1 â—¼   ENZYMATIC_REACTION ✅ 31.0 1.0 ACSN 10485906 11489965 11579131 11777960 11870632 11964313 12413632 12818165 14607900 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 1825141 18272812 19833085 20038811 20819927 21149606 21411734 24658051 26755705 2965306 6425450 9834059 9864217
HMGB1 TLR2 â—¼   DOWN_REGULATES ✅ - 13.0 1.0 ACSN 10952726 11672593 12646658 12803886 15802534 16267105 16327802 19931333 21372296 22842346 26618107 27048821 27192565
HMGB1 AGER â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20192808 9812979 19727205 25014009 32296583
TRAF2 IKBKG â—¼   ENZYMATIC_REACTION ✅ 84.0 1.0 ACSN 10542212 10754326 10820262 10925299 10952726 11112697 11274345 11280761 11438547 11460167 11875494 12133805 12433365 12646658 12811837 12907458 1431106 14607933 14625680 14660645 15099563 15199157 15465827 15485931 15536066 15592525 15644117 15699106 15749903 16243976 16413922 16713974 16818229 16878026 16970925 17237376 17254973 17301840 17363905 17404308 17462996 17485448 17693255 17916596 18264787 18345002 18633355 18641653 18716620 19392652 19411070 20038811 20138012 20184663 20300203 20435894 21133840 21217011 21232017 21411734 21807870 21826665 22435554 22955274 23086447 23170255 23390297 23422957 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 2649237 28462531 7594497 8910423 9743347
TRAF2 IKBKG â—¼   DOWN_REGULATES ✅ - 84.0 1.0 ACSN 10542212 10754326 10820262 10925299 10952726 11112697 11274345 11280761 11438547 11460167 11875494 12133805 12433365 12646658 12811837 12907458 1431106 14607933 14625680 14660645 15099563 15199157 15465827 15485931 15536066 15592525 15644117 15699106 15749903 16243976 16413922 16713974 16818229 16878026 16970925 17237376 17254973 17301840 17363905 17404308 17462996 17485448 17693255 17916596 18264787 18345002 18633355 18641653 18716620 19392652 19411070 20038811 20138012 20184663 20300203 20435894 21133840 21217011 21232017 21411734 21807870 21826665 22435554 22955274 23086447 23170255 23390297 23422957 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 2649237 28462531 7594497 8910423 9743347
AKT1 IKBKG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20837477 20098747 17660512
RAF1 MAPK1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 25435214 20179705 20141835 16364920 20130576 15035987 25907612
HRAS MAPK1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
MAPK14 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 15187187 21675959 18039929 12738796 11157753 22521293 17255949 11238443 11274345 12697810
MAPK1 LCK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 8506364 7499846 8618896 15967991 8226850 8626561
MAPK1 RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 43.0 1.0 Omnipath 17081983 18767875 15849194 19690332 11409918 14654779 23331499 23180781 8226933 20068231 18988627 21917714 18669648 19541618 18691976 16407412 19933846 9922370 15664191 8388392 19651622 10801873 8349614 18775330 9604935
MAPK1 EIF2AK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17404396 9528799
MAPK1 BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 14654779 21478863 19541618 16508002 19710016 19933846 15664191 29335436 8621729
MAPK1 CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 24342355 17290218
MAPK1 MAPKAPK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 21675959 22028470 15094067 8846784 23047924 25255283 12861023 7592979 1327754 8995385
NCF4 MAPK14 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 16778989 25877926 14530365 27558335
MAPK14 CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 14970175
MAPK14 MAPKAPK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 63.0 1.0 Omnipath 21675959 16456544 23602568 17395714 21988832 10581204 23331499 21071413 27898710 23047924 10922375 12738796 11551945 26496610 25852190 18988627 15629715 18669648 15187187 11042204 26186194 25241761 8846784 17906627 14499342 9922370 7923353 9768359 18039929 25255283 7592979 17255097 11274345 23455922
MAPK14 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 11175347 12356771 15733869 11160957 11532940 7958915 9829964 12235136 16189514 11335727 9687510 8887554 11698596 23532963 8688081 9528766 11018520 11969286 11377386 11909979
MAPK14 CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17486076 27843138
MAPKAPK2 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 11175347 17389598 10679065 12356771 15733869 8887554 9528766 11018520 11698596 11160957 11969286 12235136 7958915 9829964 9687510 20626350 11909979 8688081
ATF4 CREB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17669268 17434604 18441292 15240803 15888447 16121183
ATF4 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11564156 9295363 25241761
CDKN2B CDK6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 26186194 26578655 23602568 25416956 32296183
CCND3 CDK6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 17517622 8114739 26186194 27107012 23602568 10477583 16782892 21516116 25416956 29997244 31515488 32814053 15232106 32296183 11360184 16713569 9716181
CCND2 CDK6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10477583 17517622 16713569
JAK1 IL10 â—¼   PHYSICAL_INTERACTION 26.0 1.0 ACSN 10433356 10542212 10623821 11207245 11875494 12818165 14607900 14610620 15282297 15579430 15833879 16200688 16424049 16713974 17404308 19833085 20184663 21115385 21191065 21220452 21840487 26755705 7512720 7521688 7543512 9834059
JAK1 IL10 â—¼   SHARES_COMPLEX 26.0 1.0 ACSN 10433356 10542212 10623821 11207245 11875494 12818165 14607900 14610620 15282297 15579430 15833879 16200688 16424049 16713974 17404308 19833085 20184663 21115385 21191065 21220452 21840487 26755705 7512720 7521688 7543512 9834059
JAK1 IL10 â—¼   ENZYMATIC_REACTION ✅ 26.0 1.0 ACSN 10433356 10542212 10623821 11207245 11875494 12818165 14607900 14610620 15282297 15579430 15833879 16200688 16424049 16713974 17404308 19833085 20184663 21115385 21191065 21220452 21840487 26755705 7512720 7521688 7543512 9834059
CREB1 IL10 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11579131 15187187 15749884 16007092 16713974 17404308 20547845
IFNG IL10 â—¼   ENZYMATIC_REACTION ✅ 31.0 1.0 ACSN 10485906 11489965 11579131 11777960 11870632 11964313 12413632 12818165 14607900 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 1825141 18272812 19833085 20038811 20819927 21149606 21411734 24658051 26755705 2965306 6425450 9834059 9864217
IL10 CD80 â—¼   DOWN_REGULATES ✅ - 31.0 1.0 ACSN 10433356 10542212 10623821 10925299 11207245 11438547 11875494 12193690 12811837 12818165 14607900 15282297 15579430 15749903 15833879 16200688 16424049 16713974 17404308 17485448 20184663 20435894 20547845 21115385 21191065 21220452 23124025 23508573 24378531 26755705 9834059
CREB1 IL10 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 22140263 26408955 21986577 19564345 12493739 22116830 10540320 18263767 17202341
ACTB CDC42 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 24914801 15507212 16439214 22608513
CALM3 GRIN2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 9952395 8625412 12379661 9728925
KRAS CALM1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 27410739 12727204 28666118 16043511
CALM1 CDC42 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 22944912 21299499 21730051 9199170
CALM1 GRIN2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 9952395 8625412 12379661 9728925
CALM1 CAMKK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9822657 11395482 10187789
CCR5 GNAI3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 10508237 23109003 17084806 18538863 10644702 16183910 15337520 15251452
DRD2 GNAI3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 2898118 1445393 10978845 10384262 31160049
GNAI3 ADCY5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 23109003 15539636 7935349 16460834 11376933 8327893
CDC42 ACTG1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 24914801 15507212 16439214 22608513
GNGT1 GNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 25675501 8636150 9789084 10360181 12782285 19168127
C9 C8G â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9038722 16999828 7691959 17505110 16079145
CALM2 GRIN2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 9952395 8625412 12379661 9728925
C3 CR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 10382758 2551147 9988761 2141838
CD40LG CD40 â—¼   PHYSICAL_INTERACTION 16.0 1.0 ACSN 11207245 11581322 11698286 11964292 14764699 15034038 15197224 17200410 17317815 17371980 17513775 23002440 23125331 7523569 8760829 9359474
CD40LG CD40 â—¼   PROTEIN_INTERACTION 16.0 1.0 ACSN 11207245 11581322 11698286 11964292 14764699 15034038 15197224 17200410 17317815 17371980 17513775 23002440 23125331 7523569 8760829 9359474
CD40LG CD86 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 11207245 11581322 11698286 11964292 14764699 15034038 15197224 17200410 17317815 17371980 17513775 23002440 23125331 7523569 8760829 9359474
CD40LG CD80 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 11207245 11581322 11698286 11964292 14764699 15034038 15197224 17200410 17317815 17371980 17513775 23002440 23125331 7523569 8760829 9359474
CD40LG CD40 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 1280226 1374165 19426221 7516405 11163401 7543281 12324477 10647992 17183360
HLA-DQA1 LCK â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
HLA-DRA LCK â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
FCGR3A LCK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 8945479 18578522 8405050 15144186 8258691 15592455 16189514 89123626 15659558
LCK PLCG2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 19901323 12181444 11606584 14656219 7682059 15144186 11507089 17570479 16497976 15184383
LCK PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11526404 15032589 14583609 23109003 8397196 10488096
LCK CD28 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 7568038 22936936 27460989 16094384 10430626 8992971
ADORA2B GNAS â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 2553705 3127824 9651336 12106601 12860470
ADORA2B GNAS â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 2553705 3127824 9651336 12106601 12860470
GNAS ADCY5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9228084 9748257 9268375 21406690
TRAF2 CASP8 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15024054 20696707 19278658 10837247 19416807 21235526
LTBR TRAF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 14517219 12169272 15743811 12571250 16713569
CD40 TRAF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 47.0 1.0 Omnipath 20614026 21041727 9133417 25416956 12637493 10352240 16713569 16260598 15485859 25502805 12220533 18635759 25910212 9990007 17353931 8855313 10428814 21282461 10411888 17332487 32296183 16282325 20676093 19667091 9168896 27716849 20449947 9718306 31515488 10318845 21071692 11562359 9020361
TRAF2 CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17145710 12887920 20203691 16227629 21741934 17047155 22421964 30054040 11340079
IFNG JAK1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 16467876 7617032 7673114 12438563 10986460 7615558 1396683 8550631
JAK1 IFNG â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
JAK1 IFNG â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
JAK1 PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9774657 15021914
IFNG TLR2 â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10485906 11489965 11579131 11672593 11777960 11870632 11964313 12413632 12818165 14607900 15634932 15778339 15811952 15814715 16267105 16286920 16424049 16713974 17016554 17559085 1825141 18272812 19833085 20038811 20819927 21149606 21411734 24658051 26755705 2965306 6425450 9834059 9864217
CREB1 IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 20979795 11907114 20006311 12928400 16713974 22413812 7759501 12626576 9834094 15879136 20685939 18641343 9503023
CYBA CYBB â—¼   PHYSICAL_INTERACTION 25.0 1.0 ACSN 10679059 10714681 11062502 11146654 11385609 11747822 11907067 12626562 12740575 14697347 15169870 15184873 15536084 15927447 17517963 18423981 18809714 19372727 19380816 19732719 21178402 21383238 22157818 22827577 27331412
CYBA NCF4 â—¼   PHYSICAL_INTERACTION 25.0 1.0 ACSN 10679059 10714681 11062502 11146654 11385609 11747822 11907067 12626562 12740575 14697347 15169870 15184873 15536084 15927447 17517963 18423981 18809714 19372727 19380816 19732719 21178402 21383238 22157818 22827577 27331412
CYBA CYBB â—¼   SHARES_COMPLEX 25.0 1.0 ACSN 10679059 10714681 11062502 11146654 11385609 11747822 11907067 12626562 12740575 14697347 15169870 15184873 15536084 15927447 17517963 18423981 18809714 19372727 19380816 19732719 21178402 21383238 22157818 22827577 27331412
CYBA NCF4 â—¼   SHARES_COMPLEX 25.0 1.0 ACSN 10679059 10714681 11062502 11146654 11385609 11747822 11907067 12626562 12740575 14697347 15169870 15184873 15536084 15927447 17517963 18423981 18809714 19372727 19380816 19732719 21178402 21383238 22157818 22827577 27331412
HRAS RAF1 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
RAF1 HRAS â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 10358164 11532940 12566895 14764585 15516985 16102570 19289794 19565474 24027568 7510700 8551221 9069260 9763606 9846483
RAF1 HRAS â—¼   SHARES_COMPLEX 14.0 1.0 ACSN 10358164 11532940 12566895 14764585 15516985 16102570 19289794 19565474 24027568 7510700 8551221 9069260 9763606 9846483
RAF1 HRAS â—¼   ENZYMATIC_REACTION ✅ 14.0 1.0 ACSN 10358164 11532940 12566895 14764585 15516985 16102570 19289794 19565474 24027568 7510700 8551221 9069260 9763606 9846483
KRAS RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 53.0 1.0 Omnipath 10958680 12750173 9516156 12932319 9665134 10783161 8805624 1386920 1639773 8340422 8601312 19595761 23331499 16041367 21071413 8332195 9446616 10882715 25852190 10531446 1996324 19029954 8503013 16093354 19541618 23153539 16293107 1708096 19933846 26721396 11136732 10205168 20802526 31980649 7760835 18775988 8307946 12917261 11134016 20080631 8180183 1990291
AKT1 RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 51.0 1.0 Omnipath 19197339 11971957 18767875 20230923 10576742 20068231 17570479 16189514 18669648 25241761 18691976 10576741 10618391 20688159 21745501 12087097 12801936 12048182 22798428 16854453 19058874 11997508
HRAS RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 147.0 1.0 Omnipath 17145710 18273062 9523700 1639773 8601312 19595761 20133694 11032808 9154803 10882715 14654780 1996324 19222999 16301319 11948414 8530446 7969158 11313862 9150145 20080631 1990291 12750173 15031288 12932319 9665134 8805624 8340422 1386920 23331499 16916524 16041367 23180781 18988627 20178605 15688026 15664191 22169110 11733498 7862125 8180183 19063885 12391160 9144171 8035810 9020159 14724584 19696784 21779497 9261098 12173045 12620389 8628317 19914712 1708096 19933846 26721396 7730360 10205168 8332187 16803888 18775988 12917261 9099670 10545207 25684575 8670882 10783161 12379659 10887184 17569879 21071413 8332195 7523381 10531446 24929361 8503013 16093354 19541618 10369681 8911690 18073111 11136732 10922060 7760835 11134016
PRKCG RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 8288587 17053865
YWHAH RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12801936 11697890 8702721 17979178
PRKCB RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8288587 1386920 12917261 22826029
PIK3R2 HRAS â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
HRAS BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 17145710 7706312 14970219 18567582 12932319 8073291 1386920 23331499 8601312 9154803 18988627 8668348 21779497 19541618 19933846 17563371 18098337 16803888 26165597 24441586 16135787 12917261 15710605 10545207
CDC20 CCNA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 15577895 10679238 18471975 15840442 25669885
CD80 CD86 â—¼   PHYSICAL_INTERACTION 25.0 1.0 ACSN 10477595 11207245 11964292 12810107 14764699 15034038 15197224 17513775 17629517 18585785 20231889 20805416 21220452 22076556 22437870 23390297 24218453 25215878 25384214 25582338 26405600 7512027 7523569 8920882 9359474
CD80 CD86 â—¼   PROTEIN_INTERACTION 25.0 1.0 ACSN 10477595 11207245 11964292 12810107 14764699 15034038 15197224 17513775 17629517 18585785 20231889 20805416 21220452 22076556 22437870 23390297 24218453 25215878 25384214 25582338 26405600 7512027 7523569 8920882 9359474
CD40 CD80 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 11207245 11581322 11698286 11964292 14764699 15034038 15197224 17200410 17317815 17371980 17513775 23002440 23125331 7523569 8760829 9359474
CD80 CD28 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 11964292 12810107 14764699 15197224 17513775 17629517 18585785 20231889 22437870 23390297 25215878 25582338 26405600 7512027 7523569 9359474
CD80 CD28 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 21530327 7964482 22437870 2164219 1847722 23954143 15610849 7545666 21982860 21487479
CYBB NCF4 â—¼   PHYSICAL_INTERACTION 25.0 1.0 ACSN 10679059 10714681 11062502 11146654 11385609 11747822 11907067 12626562 12740575 14697347 15169870 15184873 15536084 15927447 17517963 18423981 18809714 19372727 19380816 19732719 21178402 21383238 22157818 22827577 27331412
CYBB NCF4 â—¼   SHARES_COMPLEX 25.0 1.0 ACSN 10679059 10714681 11062502 11146654 11385609 11747822 11907067 12626562 12740575 14697347 15169870 15184873 15536084 15927447 17517963 18423981 18809714 19372727 19380816 19732719 21178402 21383238 22157818 22827577 27331412
CAMK4 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11970865
CREB1 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 47.0 1.0 Omnipath 10866654 18599546 15585582 7870178 8028671 11313407 16007092 8413673 11564156 15691881 9829964 15073328 20403362 11259575 17476304 17707401 20541704 16799563 7870179 11123304 27789289 7913207 12933667 8663317 8004670 11483993 12198160 9413984
CCNE2 SKP2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 16209941 10375532 15199159 11231585
AKT1 SKP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23807222 28446188 22733130 19270695 20160512 19549334 21963805
SKP2 CCNE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 19847258 19686080 19270156 17884153 19622404 15703371 11237742 12648680 11900249 16697054 18931676 19809470 15459660
SKP2 CCNE2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 19847258 19686080 19270156 17884153 19622404 15703371 12648680 11900249 16697054 18931676 19809470 15459660
CD40 CD86 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 11207245 11581322 11698286 11964292 14764699 15034038 15197224 17200410 17317815 17371980 17513775 23002440 23125331 7523569 8760829 9359474
CD86 CD28 â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10477595 11207245 11964292 14764699 15034038 15197224 17513775 20231889 20805416 21220452 22076556 22437870 23390297 24218453 25215878 25384214 7523569 8920882 9359474
CD86 CD28 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 21530327 22437870 18205792 23954143 11021528 21931534 21487479 7513726
CD28 PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23109003 17722974 22315502 8146197 16107703 7509360 8080844 15790353
CAMKK1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 14500673 11445557 12149249 10833263 9859994 9868760 9368760 11278835 10226025
AKT1 BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 27.0 1.0 Omnipath 19651622 20058876 14688280 11510412 25241761 20230923 20068231 18452278 11410590 17570479 10869359 18669648
AKT1 AKT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 11546794 14500673 12176337 11445557 9736715 12149249 11278835
AKT1 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 35.0 1.0 Omnipath 11175347 11756412 12356771 15733869 20452955 20398329 11160957 10217147 19216069 20214616 11463845 9829964 7958915 12235136 16680151 17646672 9687510 8887554 11698596 8688081 17680028 9528766 11018520 11969286 12519783 11909979 15725726
AKT1 YWHAH â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 20138985 15169778 9812896 17680028 11756412 11923280 20214616 16697215 10949026 10722653 20832730 18570873 18372248 11715018 20398329 17052453 18636226 15808505
CDKN2B CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 25910212 23455922 26186194 23602568 7478582 19447967 16169070 31515488 16189514 32296183 26496610 9111314 9042862 9163429 21900206
CCND3 CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 43.0 1.0 Omnipath 11896535 25416956 16985050 34591612 21988832 14597415 17517622 16782892 10342870 21516116 23880157 15232106 16189514 11360184 26496610 25910212 26186194 27107012 10477583 19237555 32296183 14641107 9106657 9508775 31515488 9716181
CCND2 CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 25910212 17517622 27107012 11896535 10477583 9325318 31515488 16189514 32296183
EGR2 CHD4 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 16136673 16574654 15836632 18456662 8918830 10656257
CREB1 GRIN2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15774772 16313514 23012887 22364833
CREB1 CCNA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 11160720 20857405 8641461 17325033 12869629 19343785
CREB1 BDNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 17599098 19712055 25031400 11719924 21335064 32603820 14735135 11377882 19046370 22179316 21677163 17456785 23946409 17164818 9581764 18063565 9581763 16337876 20100784
AKT2 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 19216069 17680028 11756412 16680151 20214616 11463845 20452955 9829964 20398329 17646672 10217147
AKT3 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 19216069 17680028 11756412 16680151 20214616 11463845 20452955 9829964 20398329 17646672 10217147
CAMK4 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 11175347 12356771 15733869 11160957 8195196 7958915 9829964 12235136 9687510 7864890 8887554 11698596 11970865 8688081 17389598 9528766 12835716 11018520 11969286 11909979
ADORA2B GNG2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 2553705 3127824 9651336 12106601 12860470
GNB1 GNG2 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
PDYN GNG2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9544801 16415903 11786497 10215864
ADORA2B GNG2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 2553705 3127824 9651336 12106601 12860470
GNB1 GNG2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23739333 8636150 9789084 10339615 12606627 15889144 15782186 11294873 18611381 10696571 19376773 12782285 19168127
GNG2 GNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23739333 8636150 9789084 10339615 12606627 15889144 15782186 11294873 18611381 10696571 19376773 12782285 19168127
CCR5 GNAI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 10508237 23109003 17084806 18538863 10644702 16183910 15337520 15251452
GNAI2 ADCY5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 23109003 15539636 7935349 16460834 11376933
CCR5 GNAI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 10508237 23109003 17084806 18538863 10644702 16183910 15337520 15251452
GNAI1 ADCY5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 9748257 23109003 15539636 7935349 16460834 11376933
PDYN GNB1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9544801 16415903 11786497 10215864
ADORA2B GNB1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 2553705 3127824 9651336 12106601 12860470
ADORA2B GNB1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 2553705 3127824 9651336 12106601 12860470
HLA-DRA HLA-DMA â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 9606180 7481823 9075930 9311912 7667286 8046351 10631952
AKT3 CREB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 19216069 17680028 11756412 16680151 20214616 11463845 20452955 9829964 20398329 17646672 10217147
KRAS BRAF â—¼   PHYSICAL_INTERACTION 14.0 1.0 Reactome 24937142 16294014 12932339 7744815 9020159 15035987 16364920 11325826 16041367 24347342 12932319 10205168 21441910 23993095
YWHAH BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 8085158 8085159 10931830 7744815 8668348
KRAS BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 1386920 23331499 19541618 8601312 14970219 18567582 16135787 12932319 17563371 12917261 19933846 21779497 17635919 19223544 15710605 8073291
AKT3 BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 10869359 18451171 11293329 19493313
NCF4 MAPK11 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 16778989 25877926 14530365 27558335
CAMP FPR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11015447
PIK3R2 KRAS â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
HLA-DQA1 HLA-DMA â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 9606180 7481823 9075930 9311912 7667286 8046351 10631952
TBPL1 GTF2A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15767669 24835508 12682363 10523649
GRIN2B GRIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12191494 19487695 15030493 8139656
C5 C5AR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 35.0 1.0 Omnipath 9881961 11773063 9553099 15661745 10602324 1847994
C9 C8B â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9038722 16999828 7691959 17505110 16079145
C9 C6 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9038722 16999828 7691959 17505110 16079145
C9 C8A â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9038722 16999828 7691959 17505110 16079145
PRKCB EWSR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19076070 9341188
PRKCB GRIN2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 17570479 12147342 11306676 8940188
CAMKK2 CAMK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 9822657 11395482 21957496 8621423 8702940 7642608 15262966 19506079 8631893 8636117 7615569 15143065
ADCY5 CAMP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23109003 15539636 7935349 16460834
PRKCG GRIN2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 12147342 11306676 8940188
C9 C7 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9038722 16999828 7691959 17505110 16079145
CAMKK1 CAMK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 9822657 9705275 8621423 10770941 8702940 15769749 10833263 15262966 9163534 19506079 7615569 15143065