MDM2
|
MDM4
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
17159902
5219425
|
NFYC
|
NFYB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5215853
12401788
|
IKKA
|
P53
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.81
|
0.81
|
HIPPIE
|
32707033
11805286
16713569
17434128
|
MYC
|
TDG
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
21150319
26496610
|
SKP2
|
P73
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
NFYC
|
P73
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
15454570
12167641
|
LMBL1
|
P73
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
CF141
|
P73
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
NFYB
|
EP300
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
10075648
9799238
15454570
|
EP300
|
P63
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
30986748
25911675
23589370
15965232
|
IER2
|
P73
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
26186194
|
KAT2B
|
MDM2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
838.0
|
0.83
|
STRING
|
36370105
|
TDG
|
P73
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
10961991
18951877
|
TDG
|
P53
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
10961991
18951877
|
P73
|
NFYB
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
15454570
12167641
|
P53
|
NFYB
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
23734815
15831478
16959611
|
P63
|
DAXX
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
15339933
12954772
|
P73
|
KAT2B
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
14614455
18663001
|
MDM4
|
P73
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
28514442
29523541
21088494
30603043
33961781
11223036
|
DAXX
|
P73
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
15339933
12954772
|
P53
|
ABL1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
10713716
16713569
10629029
|
MYC
|
EP300
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
15616592
16287840
32140074
16126174
17157259
12776737
|
IKKA
|
MYC
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
33461590
21575199
|
P53
|
ITCH
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
21474069
32807901
16908849
18559494
|
P73
|
P53
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
9802988
25417702
21508668
9891077
11238924
|
MYC
|
SKP2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
871.0
|
0.87
|
STRING
|
36370105
|
EP300
|
MDM2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
874.0
|
0.87
|
STRING
|
36370105
|
SKP2
|
EP300
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
22770219
18243116
26593157
|
P63
|
YAP1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
27780825
11278685
|
WWOX
|
P73
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
15070730
24550385
|
IKKA
|
P73
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
17452332
21482671
|
DAXX
|
MDM2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
881.0
|
0.88
|
STRING
|
36370105
|
EP300
|
KAT2B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
883.0
|
0.88
|
STRING
|
36370105
|
KAT2B
|
EP300
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
8684459
12888487
9267036
12419806
21413932
22384255
20870727
33051058
|
MDM2
|
DAXX
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.89
|
0.89
|
mint
|
6799761
18566590
|
NFYC
|
MYC
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
10446203
11282029
|
P73
|
MYC
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
12080043
11844794
|
MYC
|
SKP2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
23277542
12769844
12963825
26038816
17157259
24259667
|
MYC
|
P53
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
21150319
30415952
28628118
28205554
|
P63
|
P73
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
28514442
11238924
19815500
17446929
33961781
22252508
10373484
|
ABL1
|
P73
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
11278685
10391250
10391251
25893286
19442657
|
ABL1
|
MDM2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
16702947
25624478
12110584
|
MYC
|
ABL1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
21400515
23029531
19602047
|
EP300
|
MDM2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
15154850
20234175
16713569
11070080
9809062
28196907
15013777
|
EP300
|
P53
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
9809062
15295102
21471221
26229107
15337767
23010591
18485870
15558054
22266186
15509808
26625199
9194564
23402884
23870121
17438265
16959611
12690203
17906639
24821727
15664194
21187340
33196849
17977830
11804596
25288747
15186775
18612383
23796514
19234109
27818144
19339993
24157709
9652736
28757384
12499368
17452980
9891054
23880760
31167125
15542844
22013068
16713569
9288740
17189186
11782467
16543236
23329847
10942770
26302407
23307557
22074660
19218448
19217391
10601022
16024799
16782091
12501250
11433299
22731250
23728348
10518217
9194565
25651062
12724314
14612423
16611888
19805293
18243116
32807901
29706626
20234175
16678111
14759370
25867071
25156994
11907332
16438982
16135789
11070080
11359905
25753752
16537920
9744860
18391200
15965232
10490106
16928824
12162806
|
EP300
|
P73
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
10648616
11804596
15175157
19218448
18663001
15893728
15454570
25675294
|
MDM2
|
EP300
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
9809062
11070080
16713569
|
MYC
|
KAT2B
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
15572685
35140242
12660246
|
KAT2B
|
P53
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
19680552
17977830
16678111
15965232
20589832
10891493
12068014
17189186
9891054
10490106
16537920
9744860
12501250
14614455
16959611
|
KAT2B
|
MDM2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
21209460
21060154
32404984
14769800
12068014
28286521
|
MDM4
|
MDM2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
28514442
10629057
32300648
25512388
21988832
25384516
25809483
17616658
25105592
12874296
31796886
29295817
32075226
20705607
17301054
22493164
25703327
27777309
29523541
27617579
23028042
20473904
22120712
22333590
22902369
22745160
12860999
19432880
21925390
28205554
25659040
19838211
33985974
16055726
25961923
32427989
18566590
22266850
18219319
29057323
10608892
30598450
29524278
25825738
17159902
24813712
31024344
27621617
15604276
29262653
19619542
10218570
28628118
16227609
10827196
12393902
24755078
20724842
34551723
27215386
11606419
20484049
12370303
23671280
26001071
26720344
33961781
12483531
23946421
19683495
26359458
|
P73
|
MDM2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
20588255
10435614
25417702
21261729
19218448
21088494
10321734
26025930
10469568
30603043
25301064
18499675
11223036
10207051
|
MDM4
|
P53
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
28514442
10629057
29023092
30672125
31152661
17110929
19521340
10075736
30832340
22807444
12874296
25609649
11528400
24445145
17080083
18677113
20705607
27249653
9226370
17301054
18485870
26148237
27114532
16024788
22374672
24127580
18316739
26876197
29523541
21088494
23028042
24667498
30045945
20515689
25464845
22745160
19432880
21925390
28205554
20174603
21965653
25961923
21075307
22266850
8895579
28487147
32511789
10608892
30598450
25825738
19305137
19255450
11223036
15604276
16713569
28628118
16227609
10827196
12393902
20724842
24659749
12370303
23671280
17875722
33961781
31462704
26186194
23946421
31066983
19075013
15916963
19153082
|
YAP1
|
P73
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
18640976
31496812
11278685
15893728
27292796
18280240
19111660
25283809
17110958
|
P73
|
ITCH
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
30603043
17592138
15678106
17110958
32513985
|
ITCH
|
P63
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
20855944
33619536
16908849
22935697
25485500
23370280
|
WWOX
|
P53
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
12514174
31315632
16713569
14965474
16219768
15580310
11058590
|
P63
|
P53
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.91
|
0.91
|
HIPPIE
|
16713569
25417702
19345189
11238924
23687300
21741598
24554706
22575646
|
MDM4
|
MDM2
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.93
|
0.93
|
mint
|
15604276
5217417
|
MDM4
|
MDM2
|
â—¼ COLOCALIZATION
|
✅
|
|
0.93
|
0.93
|
mint
|
17159902
5219425
|
DAXX
|
MDM2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
23405218
18566590
18583933
16845383
15364927
20195357
28875283
23038753
21134643
|
P53
|
MDM2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
19303885
25417702
34408321
17268548
23252402
23880345
22807444
15094782
20962272
12529318
21726810
22124327
18981217
16173922
23318437
15558054
22524527
30584071
31626714
22301280
32516735
20174603
22912717
21075307
15848166
18566590
23483203
26882543
23402884
14671306
15001357
10889512
17908790
19411846
10640350
21561866
14499615
33503543
21986495
24998844
15908921
26673821
17098746
25362358
32066565
25739118
29295817
34362424
16595680
20591429
27336364
22745160
24462112
32427887
18467333
26578655
23261415
9271120
16055726
19357310
31591476
23169665
16338390
10608892
30464405
15542844
12612087
22266868
15550400
22331460
22914926
19071110
7686617
14559824
20959462
19941302
14596917
25512388
27129163
19597489
25609649
32904724
11351297
29121928
22487680
11709713
24127580
10562557
15358376
21584881
25312347
27826076
19098711
24980433
24413661
21887275
17116689
14612427
30948704
26001071
19857530
33061576
31138778
23802716
20234175
25313037
21988832
17616658
11744695
17666403
22525275
12897156
25156994
33020477
11925449
16152627
29876924
30244831
1614537
17363365
22474335
11112690
23443559
17297477
27905468
19085961
20479273
31940492
21261729
14517261
26908445
16866370
27893708
22653443
17470788
10488081
23370271
19223463
16751805
26556313
10734067
19411066
11223036
27856536
14704432
20124408
24240685
24842904
32901886
22948151
19234109
35140242
21084285
32894144
17848574
22737255
10561590
25168242
10435614
11697899
25543083
21572037
22920093
18604177
32874188
22659184
17591690
16845383
22444248
31239268
25283148
26186194
24200963
23826318
7689721
20047188
24314634
12167711
15308643
17318220
21857681
11431470
18815136
15950904
20705607
17525743
26876197
31177307
9529249
22374672
12915590
33650658
10601022
20837658
18223694
30097011
28205554
32334023
15247280
23776465
21268072
27308622
11713288
18234963
9582019
18784078
29487367
23776060
11713287
20484049
26720344
9131587
30109812
33961781
24361594
32807901
31066983
15824742
11562347
21454483
22157679
21088494
11070080
22575647
22083959
26540344
15210108
18332869
32528731
18172499
11094089
21132010
16414131
10827196
27031960
10892746
15280377
16023600
18665269
10202144
15058298
29549180
16212962
16905769
11278372
20657550
9809062
15295102
26238070
22391559
18061646
17310983
18485870
9278461
21925390
20659896
9824166
23150668
25637791
30598450
19160491
28605833
12690203
22467867
31594538
11572869
11384992
11486026
27807478
17936559
30679555
16678796
30252118
31652301
15144954
22411991
22084066
30175854
21478269
27543608
16624812
17290220
32097779
17301054
20694676
11714701
24667498
20395212
16547496
12381304
8058315
22266850
29755129
22085928
17159902
10196247
21316347
27886165
27215386
25384516
7926727
16964247
19081178
32198344
11046142
28549433
26350565
31533005
12867035
10321734
19590512
22991965
25277184
24207125
18541670
19166840
25103245
30320919
26883110
20235143
17139261
11597128
21071676
19568783
18813780
19805293
17056014
17989425
21317885
17234751
20588255
21170087
10347217
11839577
25954860
21060154
24926618
21750659
16331255
29269425
27811966
19305137
24659749
9450543
23201157
30879903
16870621
28362432
21149449
20570896
23609977
33765973
27106262
33355139
34040386
22588298
22389628
19033382
18264029
27462439
31092600
12208736
17369817
28082682
16579792
23246961
20708156
15013777
21465263
28542145
23572512
19483087
31665549
22975381
17438265
15604276
11178989
24488098
16432196
22227409
28628118
30005830
20639885
20847049
9363941
31406141
19816404
26475964
29899406
16861890
30320499
20660730
19332559
14702041
11284721
18316739
19837670
25464845
12426395
10681559
17302414
16107876
22510990
15154850
21098709
19106616
10722742
19188367
22366412
29524278
21084564
23134341
25624478
30455251
20173098
12620407
9223638
16713569
17426254
31647545
10766163
30454706
21471462
24621507
23652204
19153082
8875929
31152661
18309296
31968249
31796886
15122315
30532073
10980696
17080083
15064742
11285227
29547122
21965653
33495326
23728348
15242646
17347673
12842086
12944468
19255450
23671280
22916255
17875722
30355102
14741215
23946421
20591651
15053879
28514442
25241761
24567357
16215989
19656744
30832340
22262183
27249653
26203195
16857591
15313915
15933712
28223335
20542919
12552135
24643130
27282385
20080206
28553961
22819825
33579943
16159876
9724739
17380154
22318540
29997244
29670376
22103682
22032989
28394340
31903119
|
NFYC
|
NFYB
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
28514442
32296183
21988832
26496610
35140242
33961781
20936779
9388234
12401788
26344197
|
DAXX
|
P53
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.99
|
0.99
|
HIPPIE
|
25241761
16713569
14557665
12954772
15364927
16845383
32545337
21482821
23038753
27626385
28875283
12482984
15339933
21134643
|
MDM2
|
MDM4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
NFYB
|
NFYC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
ABL1
|
YAP1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
12.0
|
1.0
|
ACSN
|
10837221
11804596
11971963
12628935
12709442
15459660
18835194
19788416
21051857
21199784
21435002
9168117
|
ABL1
|
MDM4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
10.0
|
1.0
|
Omnipath
|
20651945
29262653
26148237
19075013
20841568
28690977
29348869
|
ABL1
|
MDM2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
32.0
|
1.0
|
Omnipath
|
23331499
12110584
20651945
29065514
22352870
16702947
25973395
27626309
21081495
27956626
20841568
14757045
19738896
15212693
28690977
|
ABL1
|
YAP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
29.0
|
1.0
|
Omnipath
|
25361080
19788416
21199784
29449692
18955976
21051857
18280240
21435002
18701449
27807512
20841568
21214929
21945154
29179447
15459660
|
KAT2B
|
EP300
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
8684459
14500836
9267036
17496784
20870727
|
EP300
|
TDG
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
11864601
|
EP300
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
19.0
|
1.0
|
Omnipath
|
17145710
22290435
19623618
11804596
23343194
22761862
16039586
12776737
17157259
17143292
12660246
15576399
21151179
15522869
17306568
19407812
17666529
21285352
19619488
|
MYC
|
MDM2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
15655352
12695333
19649205
10348347
|
DAXX
|
MDM2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
17.0
|
1.0
|
Omnipath
|
17145710
21134643
16845383
15364927
18566590
23405218
18583933
20195357
23038753
|
MDM2
|
MDM4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
69.0
|
1.0
|
Omnipath
|
17145710
10218570
17616658
16511560
22266850
12874296
21925390
25825738
21988832
25512388
16227609
22493164
22902369
25659040
18219319
12963717
15604276
18566590
12370303
19838211
26359458
27617579
25809483
34551723
10608892
23028042
22120712
25703327
12860999
32300648
16055726
24813712
17301054
12483531
23671280
17159902
27621617
25105592
20484049
20724842
27215386
10827196
26001071
11606419
23946421
19683495
20705607
24755078
25384516
20473904
12393902
|
MYC
|
SKP2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
24259667
12963825
12769844
23792459
21245140
24177224
23277542
|
SKP2
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
12.0
|
1.0
|
Omnipath
|
17145710
24259667
12963825
12769844
17157259
23277542
20852628
16376880
35260179
26038816
|
MYC
|
NFYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
11282029
10446203
|
ITCH
|
YAP1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
8.0
|
1.0
|
ACSN
|
10940313
11318614
16469705
16861923
18552861
18628966
21107885
21383157
|