PSEN1
|
CDC37
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
21163940
114280
|
CDC37
|
APOE
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
21163940
114280
|
PRAM1
|
DYNC1H1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
TP53
|
DYNC1H1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
9781666
9627114
|
FXR2
|
GOLGA2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
3002166
21653829
|
A2M
|
LYN
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
LYN
|
APP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
TP53
|
PML
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5216620
12915590
|
SUMO1
|
PML
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17036045
5219211
|
PSEN1
|
APP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
21163940
114280
|
PSEN1
|
APOE
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
21163940
114280
|
SUMO1
|
SP100
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16189514
5217968
|
TP53
|
SUMO1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11420669
21187340
|
KLK6
|
SUV39H1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
HDAC3
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16847267
0510834103
|
TP53
|
DLST
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17916908
21191025
|
TP53
|
FAS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
9841917
|
PRAM1
|
CRYAA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
PRAM1
|
CALR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
CALR
|
APP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
CDH1
|
PRAM1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
KLK6
|
APP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
PRAM1
|
APP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
21163940
114280
|
RNF32
|
APP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
21163940
114280
|
RNF32
|
APOE
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
21163940
114280
|
PRAM1
|
DLST
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEK7
|
PRAM1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
PRAM1
|
MAST1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
21163940
114280
|
PRAM1
|
KLK6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
PRAM1
|
A2M
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
21163940
114280
|
H1-4
|
PRAM1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
000924
30021884
|
RNF32
|
PRAM1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
21163940
114280
|
PRAM1
|
CDK5R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
H1-4
|
RNF32
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
000924
30021884
|
SP100
|
SUMO1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
812.0
|
0.81
|
STRING
|
36370105
|
APP
|
CALR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
824.0
|
0.82
|
STRING
|
36370105
|
SKAP1
|
SKAP2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
26186194
|
NEK6
|
NEK7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
847.0
|
0.84
|
STRING
|
36370105
|
RARA
|
SUMO1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
15171703
24819975
|
SUMO1
|
MBD1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
17066076
24654937
|
APP
|
KLK6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
863.0
|
0.86
|
STRING
|
36370105
|
APOE
|
APP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
871.0
|
0.87
|
STRING
|
36370105
|
PML
|
RARA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
875.0
|
0.87
|
STRING
|
36370105
|
SUMO1
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
876.0
|
0.87
|
STRING
|
36370105
|
PML
|
HDAC3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
16189514
11259576
|
PML
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
883.0
|
0.88
|
STRING
|
36370105
|
RARA
|
PML
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
11050004
1311253
16189514
16713569
16540467
10882117
17560333
18073335
10610177
12935927
20159610
|
SUMO1
|
SP100
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
11313457
16189514
25416956
32296183
16524884
21880768
24654937
15017387
24637324
10212234
17491593
9412458
|
NEK6
|
NEK7
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
28514442
17353931
32814053
33961781
26186194
32707033
|
FXR2
|
LCP2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.89
|
0.89
|
HuRI
|
32296183
|
BCAR1
|
LYN
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
9581808
9020138
|
SUMO1
|
PML
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
11948183
16189514
9885291
19015637
21305000
23028697
28851805
23604351
15017387
22155184
21057547
19380586
24190887
20826694
20972456
23830076
17027752
24654937
25497731
9756909
21779164
31879127
17081986
18625722
8806687
17081985
17344210
19217413
17036045
18474224
9452416
20188669
16501610
22406621
22875967
9427741
15561718
21098080
11080164
11160742
|
NCOR1
|
PML
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
11430826
10882117
16713569
|
TP53
|
PML
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
14992722
18056437
14715247
|
TP53
|
CDH1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
15383401
20332115
21478913
|
NCOR1
|
RARA
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
9531570
19377461
10336495
16606617
25303530
21988832
27107012
9121466
10882117
15604093
16469706
30532072
18978041
15336696
7566114
9486655
20543827
|
SKAP2
|
LYN
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.93
|
0.93
|
HIPPIE
|
29568343
9837776
|
HDAC3
|
NCOR1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
16917504
11466315
10944117
21258344
11509652
16195251
16469706
14722073
15601853
12628926
11931768
11804585
14527417
16980585
23752268
29523594
16713569
10860984
11013263
|
APP
|
PSEN1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
975.0
|
0.97
|
STRING
|
36370105
|
PML
|
SUMO1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
978.0
|
0.97
|
STRING
|
36370105
|
NCOR1
|
RARA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
983.0
|
0.98
|
STRING
|
36370105
|
LYN
|
BCAR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
9581808
9020138
10428862
|
SUMO1
|
PML
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
25.0
|
1.0
|
Omnipath
|
22875967
9756909
25497731
17036045
21057547
18931695
19217413
8806687
16189514
17081985
11080164
11948183
9885291
19380586
17344210
|
PSEN1
|
CDH1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
10635315
11226248
16126725
11953314
|
TP53
|
CDK5R1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
Reactome
|
10604467
17591690
12064478
18490454
10500146
|
TP53
|
FAS
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
18.0
|
1.0
|
Omnipath
|
10101800
12788915
15580300
16317104
16322229
14719118
16557594
20797428
11103825
19615968
7539102
12447615
12944915
12963547
11313989
16951143
9841917
|
HDAC3
|
NCOR1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
11.0
|
1.0
|
ACSN
|
11399519
11875494
15644117
16127449
17260466
17681149
17689680
21234400
23390297
6357187
8871614
|
HDAC3
|
NCOR1
|
â—¼ SHARES_COMPLEX
|
|
|
11.0
|
1.0
|
ACSN
|
11399519
11875494
15644117
16127449
17260466
17681149
17689680
21234400
23390297
6357187
8871614
|
NCOR1
|
HDAC3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
24.0
|
1.0
|
Omnipath
|
11509652
11013263
16195251
11931768
16469706
21258344
17694085
10860984
16917504
10944117
23752268
16713569
14527417
11466315
11804585
12628926
15601853
|
APOE
|
APP
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
9202294
10559559
10428074
10842709
17116874
|