ABL1
|
NOTCH3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17474147
8109998
|
ABL1
|
EFNA5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17474147
8109998
|
ABL1
|
CDKN1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11753601
9916993
|
PRKCA
|
ABL1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
10713049
|
MDM4
|
ATM
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
15788536
16163388
|
MDM2
|
ATM
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
19816404
21986495
|
E2F3
|
ATM
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18469863
12527885
|
IRS1
|
ATM
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18762365
|
HMGA2
|
ATM
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
21339738
|
E2F3
|
ATM
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
12527885
18319725
|
ATM
|
HMGA2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
21339738
|
MAPK1
|
BCL2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5217079
15225643
|
NOTCH1
|
BCL2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
9881968
16990763
|
MAPK1
|
BCL2
|
â—¼ PHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
intact
|
5217079
15225643
|
E2F2
|
BCL2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11559537
18319725
|
NFKB1
|
BCL2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11704864
11313951
|
BCL2
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15210690
|
MYC
|
BCL2L11
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16169462
21899728
|
DNMT1
|
BCL2L11
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17626006
23394612
|
MYC
|
BCL2L11
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
12209154
|
EZH2
|
BRCA1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
23624935
21406404
|
BRCA1
|
CYP1B1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16567799
|
BRCA1
|
CDKN1B
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18025037
16331276
|
BRCA1
|
NFKB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16713569
12700228
|
EZH2
|
CCND1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20132185
21697275
|
RASSF1
|
CCND1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
12024041
|
EGFR
|
CCND1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
7945309
|
NOTCH1
|
CD44
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
10933396
15107403
|
RAF1
|
CDC25A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5220486
7644510
|
E2F3
|
CDC25A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
15210709
18319725
|
E2F1
|
CDC25A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15210709
18319725
|
CDC25A
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
15672448
|
FGFR3
|
CDKN1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NOTCH1
|
CDKN1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11306509
14670925
|
E2F3
|
CDKN1A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
10030670
18319725
|
HNRNPK
|
CDKN1A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16360036
|
PLCG2
|
CDKN1A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
31575057
|
PLCG1
|
CDKN1A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
31575057
|
RHOA
|
CDKN1B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
0805057106
19470470
|
CDKN1B
|
CCND2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16189514
5217968
|
EZH2
|
CDKN1B
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
18980972
21765901
|
RHOA
|
CDKN1B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
19470470
23333463
|
MYC
|
CDKN1B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
24704206
26701207
|
CDKN1B
|
RHOA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
19470470
23333463
|
CDKN2A
|
CDK6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
15232106
5217098
|
HMGA2
|
CDKN2A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
20074583
18957199
|
EZH2
|
CDKN2A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
20574448
|
PLCG1
|
DDIT4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
19557001
7255791
|
E2F2
|
E2F1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
7958836
|
E2F1
|
RASSF1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23251702
20877461
|
E2F1
|
MAPK1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18396012
|
MAPK3
|
E2F1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
14967450
22802261
|
EGFR
|
E2F1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16299810
|
PTEN
|
E2F1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17218262
|
E2F1
|
NFKB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
9368006
|
E2F1
|
HNRNPK
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
19541929
17001603
|
E2F1
|
PTGS2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15867358
18319725
|
E2F1
|
E2F2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15014447
18319725
|
E2F1
|
DNMT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18319725
15867357
|
E2F1
|
MCL1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
11857079
18319725
|
IRS1
|
EGFR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5218056
16273093
|
PLCG2
|
EGFR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5218056
16273093
|
EGFR
|
CRKL
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16729043
5218694
|
EGFR
|
NRAS
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
23220880
22908275
|
EGFR
|
KRAS
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
23220880
22908275
|
EGFR
|
HRAS
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
23220880
22908275
|
EGFR
|
HRAS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17496910
17673906
|
EGFR
|
PTGS2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19531499
|
EGFR
|
PIK3CA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17496910
1845983
|
PLCG2
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17474147
8109998
|
PIK3CA
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
GRB2
|
ERBB3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16729043
5218694
|
GRB2
|
HNRNPK
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5216105
12577067
|
GRB2
|
FSCN1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5216105
12577067
|
MAPK3
|
GRB2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
7739560
8816480
|
MAPK1
|
GRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
8994038
|
HNRNPK
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
8349701
|
RAF1
|
MAPK1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
20674547
15664191
|
MAPK1
|
MAP2K1
|
â—¼ PHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
intact
|
23241949
8412360
|
PRKCE
|
MAPK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
11350735
|
PRKCB
|
MAPK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
8903320
10327068
|
MAPK1
|
CREBBP
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
8941362
|
RAF1
|
MAPK3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
20674547
15664191
|
MAPK3
|
IRS2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
7739560
8816480
|
MAPK3
|
IRS1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
7739560
8816480
|
PRKCE
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
16810323
16461926
|
PRKCB
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
8903320
10327068
|
MCL1
|
BMF
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
ACSN
|
11546872
23850759
|
MCL1
|
BMF
|
â—¼ PROTEIN_INTERACTION
|
|
|
2.0
|
0.8
|
ACSN
|
11546872
23850759
|
PIM1
|
MDM2
|
â—¼ PHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
intact
|
19166854
6823529
|
MDM2
|
MDM4
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
17159902
5219425
|
RASSF1
|
MDM2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
18566590
|
MYC
|
FGFR3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NOTCH1
|
MYC
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
10644343
16847353
|
MYC
|
HDAC2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20697349
|
MYC
|
PDGFRB
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
15226411
18697203
|
MYC
|
GLS
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23979920
19219026
|
MYC
|
EZH2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
21941025
19197161
|
E2F2
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11564866
18319725
|
E2F3
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11564866
18319725
|
MYC
|
DNMT3A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15616584
19786833
|
ATP6V0C
|
PDGFRB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
1334459
6624245
|
PDGFRA
|
CRKL
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
6730895
9546424
|
CRKL
|
ERBB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5218056
16273093
|
CRKL
|
ERBB3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5218056
16273093
|
CRKL
|
IRS2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
11443118
11124936
|
RECK
|
ERBB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
21255571
8085311
|
RECK
|
ERBB2
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
21255571
8085311
|
SHC1
|
ERBB3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16729043
5218694
|
PRKCA
|
SHC1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
7929214
12052829
|
HRAS
|
SHC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17138645
|
IRS2
|
SHC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11505033
15705774
|
SHC1
|
PIK3CA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
7537361
|
ERBB2
|
CRK
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5218056
16273093
|
PDGFRB
|
CRK
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
10733900
6731185
|
ERBB3
|
CRK
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5218056
16273093
|
CRK
|
AGPAT4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17474147
8109998
|
PTEN
|
PDGFRB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16456542
5218301
|
PDGFRB
|
PIK3R2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
6730293
1330535
|
PDGFRB
|
PIK3R2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17496910
11172806
|
PDGFRB
|
PIK3CA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17496910
8702949
|
NFKB1
|
PDGFB
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15175554
|
PLCG1
|
IRS2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
15644415
8034732
|
ERBB3
|
PLCG1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16273093
|
MET
|
PLCG1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
8662733
7513258
|
DNMT1
|
PTEN
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19339266
21229291
|
EZH2
|
PTEN
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
24719098
22956625
|
BMI1
|
PTEN
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
19903340
8291464
|
PTEN
|
BMI1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
19903340
|
NOTCH1
|
NOTCH4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
22330899
22363130
|
PRKCE
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11350735
|
STIM1
|
HRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
HRAS
|
ERBB2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
23220880
22908275
|
ERBB2
|
HRAS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17496910
17673906
|
ERBB3
|
HRAS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17496910
17673906
|
HRAS
|
PIK3CB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
9069260
21779497
|
NFKB1
|
CREBBP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
12456660
16135789
|
RHOA
|
RDX
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
35267019
|
ERBB2
|
PTGS2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19861462
|
NFKB1
|
CCND2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
21790895
|
EZH2
|
BMI1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
21465172
19351856
|
STIM1
|
FGFR3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
FGFR3
|
TMEM186
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
FGFR3
|
PIK3CA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
15863030
11353842
|
FGFR3
|
METTL7A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
PRKCA
|
PRKCE
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16810323
5218785
|
PRKCA
|
METTL7A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
PRKCA
|
HDAC5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
15367659
|
PLCG2
|
IRS2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
15644415
8034732
|
PIK3CD
|
IRS2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
11598010
12506011
|
MET
|
PIK3CA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
10871282
10648629
|
PIK3CD
|
PIK3CA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
9885561
10455108
|
PIK3CA
|
PIK3CB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
9885561
10455108
|
ERBB3
|
PIK3CA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16729043
17496910
|
ERBB2
|
PIK3CA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17496910
8026468
|
MAP2K1
|
MAPK6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16251502
|
PIK3CD
|
PIK3CB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
9885561
10455108
|
ERBB3
|
PIK3CD
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16729043
17496910
|
ERBB2
|
PLCG2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5218056
16273093
|
KRAS
|
ERBB2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
23220880
22908275
|
NRAS
|
ERBB2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
23220880
22908275
|
MAP2K2
|
MAPK6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18039929
|
PRKCB
|
MAPK6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
8626698
16189514
|
ERBB3
|
PIK3CB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16729043
17496910
|
DNMT3B
|
DNMT3A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20426865
15362956
|
E2F3
|
CCNE2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
8618861
10733529
|
CREB3L1
|
TMEM11
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
8153045
21516116
|
CRK
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
803.0
|
0.8
|
STRING
|
36370105
|
ERBB2
|
PIK3R2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
805.0
|
0.8
|
STRING
|
36370105
|
GRB2
|
MET
|
â—¼ PHYSICAL_INTERACTION
|
|
|
808.0
|
0.8
|
STRING
|
36370105
|
CDKN1A
|
CCNE1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.81
|
0.81
|
mint
|
16765349
5218735
|
MDM2
|
CDKN2A
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.81
|
0.81
|
mint
|
7989562
20713054
|
IRS1
|
RPTOR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.81
|
0.81
|
HIPPIE
|
16354680
19561084
30240640
|
PLCG2
|
ERBB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.81
|
0.81
|
HIPPIE
|
22973453
16273093
25241761
|
PDGFRB
|
PTEN
|
â—¼ PHYSICAL_INTERACTION
|
|
|
811.0
|
0.81
|
STRING
|
36370105
|
MDM4
|
BCL2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
19521340
24445145
|
BRCA1
|
KIF23
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
26831064
29656893
|
RHOB
|
CD44
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
34079125
31871319
|
CD44
|
MTCH2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
RHOB
|
EGFR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
34079125
31871319
|
EGFR
|
CKAP4
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
25754235
15657067
|
PDGFB
|
MDM2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
SCN3B
|
MTOR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
MYC
|
DNMT1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
30415952
29467282
|
MYC
|
CKAP4
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
21150319
29467282
|
PAK4
|
CDK6
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
SHC1
|
ERBB2
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.82
|
0.82
|
mint
|
16729043
5218694
|
RHOB
|
PAK4
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
34079125
31871319
|
SPOP
|
BMI1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
15897469
34316702
|
RAC2
|
RAC3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
DNMT3A
|
DNMT3B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
819.0
|
0.82
|
STRING
|
36370105
|
MET
|
ERBB3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
25326665
21918175
|
HRAS
|
RASSF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
820.0
|
0.82
|
STRING
|
36370105
|
STX12
|
STX4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
822.0
|
0.82
|
STRING
|
36370105
|
GRB2
|
PDGFRB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
824.0
|
0.82
|
STRING
|
36370105
|
KRAS
|
MAPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
824.0
|
0.82
|
STRING
|
36370105
|
SHC1
|
ABL1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
8112292
19380743
10194451
|
CASP3
|
MDM2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
25241761
9278461
24842904
9840926
21726810
|
SHC1
|
PLCG2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
12135708
10623845
|
IRS2
|
PLCG1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
22974441
9535722
|
RHOC
|
RHOA
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
31871319
33961781
31980649
|
ABL1
|
EGFR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
839.0
|
0.84
|
STRING
|
36370105
|
BRCA1
|
EZH2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
25531315
23624935
|
EGFR
|
CD44
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
11606076
16565089
12093135
15597342
23265944
|
CD44
|
MET
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
22897854
28628118
28205554
|
E2F1
|
NRIP1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
20410059
22629304
|
E2F1
|
E2F3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
35140242
24981860
20106982
|
GRB2
|
IRS2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
7559579
22974441
9852124
21706016
|
CCNE1
|
CDK6
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
9716181
28628118
28205554
|
EGFR
|
PLCG1
|
â—¼ PHOSPHORYLATION
|
✅
|
+
|
0.84
|
0.84
|
Signor
|
1689310
|
DNMT3B
|
EZH2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
840.0
|
0.84
|
STRING
|
36370105
|
PAK4
|
RAC3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
845.0
|
0.84
|
STRING
|
36370105
|
DNMT1
|
HDAC2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
846.0
|
0.84
|
STRING
|
36370105
|
IKBKB
|
NFKB1
|
â—¼ PHOSPHORYLATION
|
✅
|
-
|
0.84
|
0.84
|
Signor
|
11158290
|
EGFR
|
SHC4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
847.0
|
0.84
|
STRING
|
36370105
|
MAPK1
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
847.0
|
0.84
|
STRING
|
36370105
|
EFNA5
|
HERPUD2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.84
|
0.84
|
HuRI
|
32296183
|
KRAS
|
NRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
847.0
|
0.84
|
STRING
|
36370105
|
CCNG1
|
MDM2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
12556559
|
CDKN1B
|
CCNE1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.85
|
0.85
|
mint
|
34591612
|
PLCG1
|
EGFR
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.85
|
0.85
|
mint
|
9020117
6805619
|
PLCG1
|
SHC1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
8662733
8155326
10652211
|
PLCG1
|
PDGFRB
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.85
|
0.85
|
mint
|
6730306
1396585
|
RHOB
|
ROCK1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
34079125
31871319
34187934
|
PIK3CA
|
IRS1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.85
|
0.85
|
mint
|
34591642
|
DNMT1
|
EZH2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
849.0
|
0.85
|
STRING
|
36370105
|
CCND1
|
CDKN2A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
850.0
|
0.85
|
STRING
|
36370105
|
CDK6
|
CDKN1B
|
â—¼ PHOSPHORYLATION
|
✅
|
-
|
0.85
|
0.85
|
Signor
|
16160006
|
ERBB2
|
GRB2
|
â—¼ RELOCALIZATION
|
✅
|
+
|
0.85
|
0.85
|
Signor
|
14967450
|
ABL1
|
ERBB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
22973453
16273093
19275932
|
FGFR3
|
GRB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
9045692
26344197
|
PIM1
|
MDM2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
19166854
18467333
|
CRK
|
SHC1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
8035825
9837978
9461587
9617486
19380743
10464310
23397142
|
MET
|
PLCG1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
8662733
24728074
7513258
|
MAPK1
|
SHC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
862.0
|
0.86
|
STRING
|
36370105
|
BCL2
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
865.0
|
0.86
|
STRING
|
36370105
|
CREBBP
|
MDM2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
866.0
|
0.86
|
STRING
|
36370105
|
EGFR
|
RAF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
24658140
25402006
31980649
|
EGFR
|
PIM1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
24658140
25402006
31980649
|
MYC
|
CDK6
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
22094256
28628118
28205554
|
MYC
|
HDAC2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
17314511
20195357
22286234
30415952
|
MET
|
CRK
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
24828152
24728074
|
EZH2
|
HDAC2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
10581039
24981860
21685935
26344197
|
CDC25A
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
870.0
|
0.87
|
STRING
|
36370105
|
CDK6
|
CDKN1A
|
â—¼ PHOSPHORYLATION
|
✅
|
-
|
0.87
|
0.87
|
Signor
|
16508017
|
BRCA1
|
CREBBP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
871.0
|
0.87
|
STRING
|
36370105
|
HRAS
|
PIK3CA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
871.0
|
0.87
|
STRING
|
36370105
|
CDKN1A
|
MDM2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
872.0
|
0.87
|
STRING
|
36370105
|
BRCA1
|
MYC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
873.0
|
0.87
|
STRING
|
36370105
|
NRAS
|
RAF1
|
â—¼ RELOCALIZATION
|
✅
|
+
|
0.87
|
0.87
|
Signor
|
21779497
|
CRK
|
PDGFRA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
874.0
|
0.87
|
STRING
|
36370105
|
PIK3R2
|
PIK3R3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
874.0
|
0.87
|
STRING
|
36370105
|
ATM
|
BRCA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
875.0
|
0.87
|
STRING
|
36370105
|
CASP3
|
MDM2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
875.0
|
0.87
|
STRING
|
36370105
|
ABL1
|
ATM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
876.0
|
0.87
|
STRING
|
36370105
|
HRAS
|
NRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
877.0
|
0.87
|
STRING
|
36370105
|
DNMT1
|
DNMT3B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
877.0
|
0.87
|
STRING
|
36370105
|
PDGFRB
|
PLCG1
|
â—¼ PHOSPHORYLATION
|
✅
|
+
|
0.87
|
0.87
|
Signor
|
7535778
|
MAVS
|
ABL1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
28141795
19914245
|
ABL1
|
PLCG1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
10708759
1383690
17474147
|
CDKN2A
|
MYC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
880.0
|
0.88
|
STRING
|
36370105
|
CRK
|
EGFR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
881.0
|
0.88
|
STRING
|
36370105
|
CRKL
|
EGFR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
881.0
|
0.88
|
STRING
|
36370105
|
ERBB3
|
PIK3R2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
883.0
|
0.88
|
STRING
|
36370105
|
CCND2
|
CDKN1B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
884.0
|
0.88
|
STRING
|
36370105
|
EGFR
|
PIK3R2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
884.0
|
0.88
|
STRING
|
36370105
|
ABL1
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
886.0
|
0.88
|
STRING
|
36370105
|
EGFR
|
MET
|
â—¼ PHYSICAL_INTERACTION
|
|
|
887.0
|
0.88
|
STRING
|
36370105
|
MAPK1
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
887.0
|
0.88
|
STRING
|
36370105
|
ITGB3
|
SHC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
887.0
|
0.88
|
STRING
|
36370105
|
BRCA1
|
ABL1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
17352427
12024016
|
HDAC2
|
BRCA1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
21946536
10220405
16713569
|
CCND1
|
BRCA1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
17334399
16713569
9244350
|
CDKN1B
|
CCND1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.89
|
0.89
|
mint
|
34591612
|
CD44
|
ERBB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
11606076
28628118
12093135
17092940
28205554
|
EGFR
|
SHC4
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
31980649
28724758
22973453
24658140
24430869
25402006
|
EGFR
|
CRKL
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
31980649
24658140
25402006
18271526
25754235
16729043
23397142
|
ERBB3
|
GRB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
9756944
24189400
24658140
16729043
11173924
|
STX4
|
STX12
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
28514442
32296183
25416956
33961781
26186194
34079125
|
SHC1
|
MET
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
7731718
24728074
9660480
|
PTEN
|
SPOP
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
24656772
27622336
32297747
|
HDAC2
|
DNMT1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
23708667
17967891
21670149
10888872
|
DNMT1
|
EZH2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
31130994
16357870
22094255
28068325
21378168
|
PDGFA
|
PDGFRA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
889.0
|
0.89
|
STRING
|
36370105
|
IRS1
|
PIK3R2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
891.0
|
0.89
|
STRING
|
36370105
|
BAK1
|
BCL2L11
|
â—¼ PHYSICAL_INTERACTION
|
|
|
893.0
|
0.89
|
STRING
|
36370105
|
HRAS
|
KRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
893.0
|
0.89
|
STRING
|
36370105
|
CDK6
|
CDKN1B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
894.0
|
0.89
|
STRING
|
36370105
|
EZH2
|
HDAC2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
896.0
|
0.89
|
STRING
|
36370105
|
ATM
|
ABL1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
9168116
17409407
10212258
20798688
11375976
9168117
|
CRKL
|
ABL1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
16443220
22286129
7493940
14604282
8978305
9820532
18835194
9710592
33961781
8524328
19823681
7926767
16955467
24412932
|
ABL1
|
GRB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
23950177
16713569
17474147
14725908
9407116
9516488
8194526
19380743
19823681
7926767
16955467
|
ABL1
|
EGFR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
31980649
24658140
16273093
25402006
7678409
|
ABL1
|
MDM2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
16702947
25624478
12110584
|
MYC
|
ABL1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
21400515
23029531
19602047
|
ABL1
|
HDAC2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
26603102
25219501
|
APC
|
CASP3
|
â—¼ CLEAVAGE
|
✅
|
|
3.0
|
0.9
|
Reactome
|
10200466
17297457
9973322
|
ATM
|
BRCA1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
11114888
11278964
29656893
10783165
11016625
10866324
10550055
15713674
18344987
10608806
17478428
|
E2F1
|
ATM
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
22832221
23993922
12527885
|
BCL2L11
|
BAK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
22492984
12242151
|
RAF1
|
BCL2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
8929532
8910675
12488548
9194558
15849194
|
E2F1
|
BCL2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
11559537
18319725
11704823
|
BCL2L11
|
BCL2L2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
ACSN
|
23430059
23850759
9430630
|
BCL2L11
|
BCL2L2
|
â—¼ PROTEIN_INTERACTION
|
|
|
3.0
|
0.9
|
ACSN
|
23430059
23850759
9430630
|
E2F1
|
BCL2L11
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
23152504
19893569
16243973
|
MYC
|
BRCA1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
12646176
11916966
16713569
20215511
9788437
30415952
14612409
|
DNMT1
|
BRCA1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
19943104
22197621
20631324
|
E2F2
|
BRCA1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
17106239
|
E2F3
|
BRCA1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
17106239
|
EZH2
|
BRCA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
19079346
20574448
|
CASP3
|
BRCA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
12149654
|
MYC
|
CD44
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
22002305
22911891
19738061
|
SIRT1
|
CDKN1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
23474493
15130752
21719763
|
E2F1
|
BMI1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
23796898
17360938
16582100
|
E2F1
|
MDM2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
10914734
20837136
|
E2F1
|
DNMT1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
24502362
17575144
15867357
|
E2F1
|
KIF23
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
19015243
|
E2F3
|
E2F1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
14576826
10766737
18319725
|
E2F1
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
11564866
18319725
90001421
|
EGFR
|
RHOA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
18955552
20937854
15156151
|
ERBB3
|
EGFR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
21278786
24189400
27756321
18803307
17148612
25315821
22439932
10527633
23436906
23866081
10572067
|
PLCG2
|
EGFR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
25241761
31980649
22973453
24658140
16273093
25402006
|
EGFR
|
MET
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
20624308
24189400
21918175
24362532
10722725
23866081
26551075
|
EGFR
|
CRK
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
16729043
9642287
31980649
10595738
22973453
24658140
11956190
16273093
9617486
25402006
12198159
8875975
9480911
|
EGFR
|
PLCG1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
1689310
11983899
14568990
15144186
12803489
12601080
24797263
9756944
9207933
19605547
7993895
7693694
9020117
12061819
16273093
25754235
16713569
22973453
7682059
8657103
8885868
|
EGFR
|
ERBB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
11500850
25241761
30898150
17486068
11526509
9461599
23866081
17426253
10572067
11500516
24557338
8665853
15657067
19060928
16516204
19650109
20211985
25315821
23436906
21278786
25898135
32669362
1346931
24189400
21044682
18803307
16843263
28369073
7531698
16713569
17148612
21203579
17307140
1706616
16207817
7797556
12354693
11408594
|
PIK3CD
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
11002419
10995764
10448070
|
ITGB3
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
12005431
9566877
7997267
|
PDGFB
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
7935391
8388543
9739761
|
PIK3CB
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
11002419
10995764
10448070
|
PDGFRA
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
7935391
8388543
9739761
|
PDGFA
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
7935391
8388543
9739761
|
MET
|
GRB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
11063574
15546961
9660480
19433454
21222362
7511210
8662889
11439336
|
IRS2
|
GRB2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
ACSN
|
19109239
7890616
9535722
|
NFKB1
|
HMOX1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
19752329
8016102
|
MAPK1
|
MAP2K1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
10567369
19219045
8013650
|
MAPK1
|
MAP2K2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
10567369
19219045
8013650
|
RHOA
|
MAPK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
10617617
9854026
12810709
|
MAPK1
|
MARCKS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
9867858
30225354
|
MAPK1
|
BMF
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
22258404
|
MAPK3
|
MAP2K2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
10567369
19219045
8013650
|
MAPK3
|
MAP2K1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
10567369
19219045
8013650
|
RHOA
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
10617617
9854026
12810709
|
MAPK3
|
SHC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
15930121
|
MDM4
|
MDM2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
28514442
10629057
32300648
25512388
21988832
25384516
25809483
17616658
25105592
12874296
31796886
29295817
32075226
20705607
17301054
22493164
25703327
27777309
29523541
27617579
23028042
20473904
22120712
22333590
22902369
22745160
12860999
19432880
21925390
28205554
25659040
19838211
33985974
16055726
25961923
32427989
18566590
22266850
18219319
29057323
10608892
30598450
29524278
25825738
17159902
24813712
31024344
27621617
15604276
29262653
19619542
10218570
28628118
16227609
10827196
12393902
24755078
20724842
34551723
27215386
11606419
20484049
12370303
23671280
26001071
26720344
33961781
12483531
23946421
19683495
26359458
|
MTOR
|
RPTOR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
16847060
26522726
12604610
19619545
26348909
33378666
20169205
24036451
18570873
24516643
19299511
34031390
22424946
22356909
25940091
12719976
22544753
23263282
12150926
12665511
18505677
17277771
17461779
22493283
19114562
18722121
21071439
18030348
19446321
12718876
12747827
24375676
22258093
16837165
21045808
16962653
18955708
17565979
12408816
15467718
23953116
27043084
23911927
17043309
31601708
21177249
21614075
21795849
16631613
20381137
21321085
23297343
23872070
16354680
19875983
25446900
29059166
24337580
16603397
16183647
34171383
15066126
24403073
25332233
17386266
19145465
25007995
16798736
26678875
15268862
20427287
30865892
16919458
25273559
15459249
18519641
18504440
12150925
|
PRKCA
|
MTOR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
21474067
18851840
20027184
|
MYC
|
RAF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
17314511
9315742
28628118
28205554
|
MYC
|
MET
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12695333
|
MYC
|
NOTCH4
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12695333
|
MYC
|
SYNGR2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12695333
|
MYC
|
PLAU
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
20123981
17382917
22550094
|
MYC
|
PRKCG
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
15345217
9489489
23550155
|
MYC
|
NRAS
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12695333
|
MYC
|
RHOG
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12695333
|
MYC
|
CDC25C
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12747840
22446629
|
MYC
|
RHOA
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
22159222
20383141
22235332
|
MYC
|
SIRT1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12695333
|
NOTCH1
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
2191300
18490439
19219071
|
NFKB1
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
2191300
18490439
19219071
|
DNMT3B
|
RASSF1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
19854132
12879017
18006804
|
CDK6
|
CCND2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
16189514
16713569
28628118
10022865
28205554
11360184
30217970
33961781
23602568
11358847
9178893
|
PDGFA
|
CRKL
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
10508235
9546424
9739761
|
PDGFRB
|
CRKL
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
10508235
9546424
9739761
|
PDGFB
|
CRKL
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
10508235
9546424
9739761
|
NFKB1
|
CCL4
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
18270204
11342414
|
RHOA
|
EZR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
35267019
15659383
|
PIK3CD
|
SHC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
11002419
10995764
10448070
|
SHC1
|
PIK3CA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
11002419
10995764
10448070
|
SHC1
|
MAPK6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
intact
|
21900206
2001699
8089645
|
SHC1
|
PIK3CB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
11002419
10995764
10448070
|
SHC1
|
ERBB3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
16189514
9019162
9756944
24189400
22973453
24658140
16273093
16729043
11546794
8665853
9694850
|
SHC1
|
ERBB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
9710588
9019162
16713569
9756944
22973453
24658140
10085134
28065597
30898150
16843263
16273093
16729043
8665853
|
PTEN
|
SHC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
10427092
21206972
|
PDGFA
|
SHC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12767520
17496910
17673906
|
PDGFB
|
CRK
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
10508235
9546424
9739761
|
ITGB3
|
CRK
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
16581250
10777559
12640026
|
PDGFA
|
CRK
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
10508235
9546424
9739761
|
PDGFRB
|
PIK3CA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
2466336
1374684
9739761
|
PDGFRB
|
PIK3CB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
2466336
1374684
9739761
|
PDGFRB
|
PIK3R3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
17496910
16189514
11172806
|
PIK3R2
|
PDGFB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
2466336
1374684
9739761
|
PDGFB
|
PIK3CA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
2466336
1374684
9739761
|
PDGFB
|
PIK3CB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
2466336
1374684
9739761
|
PDGFB
|
PLCG1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
1396585
8443409
9739761
|
PLCG1
|
ERBB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
22973453
16273093
1676673
1683701
|
NFKB1
|
PLAU
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
11689575
17407600
20352621
|
ZDHHC9
|
HRAS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
21779492
16000296
|
PRKCA
|
CREBBP
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
11463380
17570479
20577053
|
CREBBP
|
NFKB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12789342
16835236
|
ERBB2
|
RHOA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
18955552
20937854
15156151
|
ERBB3
|
RHOA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
18955552
20937854
15156151
|
PRKCA
|
RHOA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
10592173
11284700
|
MAP2K1
|
IRS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
11160134
|
NFKB1
|
ABCB1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
18234965
12527911
19763573
|
PRKCA
|
ITGB3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
16014375
10592173
17570479
|
PRKCB
|
IKBKB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12070292
|
IRS2
|
PIK3CD
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
9113989
|
PDGFA
|
PIK3CA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
2466336
1374684
9739761
|
RAC2
|
PIK3CA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
7744773
8645157
11803464
|
PIK3CA
|
RHOG
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
7744773
8645157
11803464
|
DNMT1
|
DNMT3B
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
24423239
16481298
20155458
|
ERBB2
|
PIK3R3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
16273093
17496910
|
PDGFRA
|
PIK3CB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
2466336
1374684
9739761
|
PDGFA
|
PIK3CB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
2466336
1374684
9739761
|
PIK3R2
|
PIK3CB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
22402981
8596638
11733063
|
RPS6KA5
|
EZH2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
intact
|
21900206
2001699
8089645
|
E2F3
|
EZH2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
18319725
14532106
|
PIK3R2
|
PDGFRA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
2466336
1374684
9739761
|
PIK3R2
|
PDGFA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
2466336
1374684
9739761
|
ZDHHC9
|
NRAS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
21779492
16000296
|
ABL1
|
CRKL
|
â—¼ PHYSICAL_INTERACTION
|
|
|
900.0
|
0.9
|
STRING
|
36370105
|
CDK6
|
CDKN1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
900.0
|
0.9
|
STRING
|
36370105
|
EGFR
|
PLCG2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
905.0
|
0.9
|
STRING
|
36370105
|
CCND2
|
CDKN1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
910.0
|
0.91
|
STRING
|
36370105
|
GRB2
|
IRS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
912.0
|
0.91
|
STRING
|
36370105
|
CDKN2A
|
MDM2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
913.0
|
0.91
|
STRING
|
36370105
|
ERBB3
|
SHC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
914.0
|
0.91
|
STRING
|
36370105
|
IRS1
|
PIK3R3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
914.0
|
0.91
|
STRING
|
36370105
|
ERBB2
|
ERBB3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
916.0
|
0.91
|
STRING
|
36370105
|
CCND1
|
CDK6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
919.0
|
0.92
|
STRING
|
36370105
|
ERBB3
|
EGFR
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.92
|
0.92
|
mint
|
31862538
|
GRB2
|
ERBB2
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.92
|
0.92
|
mint
|
16273093
5218056
|
EGFR
|
PLCG1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
920.0
|
0.92
|
STRING
|
36370105
|
IRS1
|
PIK3CA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
920.0
|
0.92
|
STRING
|
36370105
|
EGFR
|
GRB2
|
â—¼ PHOSPHORYLATION
|
|
|
0.92
|
0.92
|
Signor
|
11726515
|
ERBB2
|
SHC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
922.0
|
0.92
|
STRING
|
36370105
|
MAP2K2
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
924.0
|
0.92
|
STRING
|
36370105
|
BAK1
|
MCL1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
925.0
|
0.92
|
STRING
|
36370105
|
MDM4
|
MDM2
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.93
|
0.93
|
mint
|
15604276
5217417
|
MDM4
|
MDM2
|
â—¼ COLOCALIZATION
|
✅
|
|
0.93
|
0.93
|
mint
|
17159902
5219425
|
NRAS
|
RAF1
|
â—¼ PROXIMITY
|
✅
|
|
0.93
|
0.93
|
mint
|
30194290
|
PIK3CB
|
PIK3R3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
934.0
|
0.93
|
STRING
|
36370105
|
CCNE2
|
CDKN1B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
937.0
|
0.93
|
STRING
|
36370105
|
RHOA
|
ROCK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
937.0
|
0.93
|
STRING
|
36370105
|
PIK3CB
|
PIK3R2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
938.0
|
0.93
|
STRING
|
36370105
|
BMF
|
BCL2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.94
|
0.94
|
HIPPIE
|
17289999
16697956
11546872
|
CCND2
|
CDK6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
939.0
|
0.94
|
STRING
|
36370105
|
PIK3CA
|
PIK3R3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
941.0
|
0.94
|
STRING
|
36370105
|
PTEN
|
SPOP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
943.0
|
0.94
|
STRING
|
36370105
|
NRAS
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
945.0
|
0.94
|
STRING
|
36370105
|
ERBB3
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
948.0
|
0.94
|
STRING
|
36370105
|
CDKN1A
|
CCND2
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.95
|
0.95
|
mint
|
16765349
5218735
|
ERBB2
|
EGFR
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.95
|
0.95
|
mint
|
5218411
16516204
|
CCNE2
|
CDKN1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
954.0
|
0.95
|
STRING
|
36370105
|
ERBB2
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
957.0
|
0.95
|
STRING
|
36370105
|
MAP2K2
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
958.0
|
0.95
|
STRING
|
36370105
|
CCNE1
|
CDKN1B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
959.0
|
0.96
|
STRING
|
36370105
|
PLCG1
|
GRB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.96
|
0.96
|
HIPPIE
|
16713569
7629168
7516467
9020117
21706016
10940929
16038803
9281317
|
RAF1
|
MAP2K1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.96
|
0.96
|
mint
|
7014125
19197339
|
MAP2K1
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
963.0
|
0.96
|
STRING
|
36370105
|
IKBKB
|
NFKB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
963.0
|
0.96
|
STRING
|
36370105
|
CCNE1
|
CDKN1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
964.0
|
0.96
|
STRING
|
36370105
|
ABL1
|
CRK
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
31980649
9747873
11380621
15696159
8875975
9480911
21602891
18835194
18619508
12384576
8194526
11956190
19380743
24412932
9642287
17474147
8978305
12097319
17515907
33961781
12198159
7926767
|
CDK6
|
CCND1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
15232106
16713569
10022865
24855949
17517622
33854235
11739795
14681455
24953629
11360184
33961781
10580009
17420273
21654808
11160398
9178893
19075005
|
SHC1
|
EGFR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
7518560
8034616
31980649
23956138
9544989
8610109
7542744
25402006
16729043
8665853
15657067
9742218
24797263
10049786
12577067
9756944
23799367
25187647
20935677
10766863
18271526
11408594
7506413
10635327
10595738
24189400
19531499
7542991
20473329
24430869
8662998
9020193
8887653
16273093
25754235
9388490
31959764
26551075
16713569
22973453
24658140
11196191
28065597
20067773
8810340
21278788
30544639
9130710
11370743
|
EGFR
|
GRB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
19254954
7518560
31980649
9416834
7592693
23956138
14679214
10085134
7510700
27059931
21706016
25402006
16799092
16729043
8665853
15657067
24797263
12577067
8810325
7650032
11960376
23799367
25187647
8626525
10026169
19289468
18271526
21278786
7506413
17971399
8940013
20124286
11726515
9886492
10595738
24189400
9020117
19531499
20473329
9020193
8662998
8647858
1322798
8887653
10229072
16273093
25754235
31959764
11370743
16713569
21596750
9685397
24658140
31985874
22973453
11896612
20067773
17242169
19836242
8810340
21278788
30544639
7527043
9050991
11408594
8621459
|
SHC1
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.97
|
0.97
|
mint
|
8940013
6169950
|
ERBB2
|
GRB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
9710588
11173924
21278786
16713569
9756944
24189400
31980649
22973453
24658140
30898150
16273093
17875712
16729043
11606575
8665853
|
IRS1
|
GRB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
7488107
8388384
7486683
8810325
22974441
21706016
8491186
7629070
12173038
8536716
|
CRK
|
GRB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
8810325
10962563
8662907
19380743
10970810
|
ROCK1
|
RHOA
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
21281639
31431478
8816443
14660612
12773565
8798490
31871319
|
ERBB3
|
ERBB2
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.97
|
0.97
|
mint
|
31862538
|
ERBB3
|
ERBB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
10799311
12896906
25241761
30523157
23680147
30898150
19411071
17426253
10572067
11173924
24557338
23866081
8665853
19060928
25326665
7592681
25315821
22733765
21075308
23436906
8816440
21278786
25898135
15812817
7538656
16843263
20227043
23688700
15504738
22806884
17148612
21203579
9130710
|
MAP2K1
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
971.0
|
0.97
|
STRING
|
36370105
|
KRAS
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
972.0
|
0.97
|
STRING
|
36370105
|
EGFR
|
ERBB3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
973.0
|
0.97
|
STRING
|
36370105
|
MAP2K1
|
MAPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
974.0
|
0.97
|
STRING
|
36370105
|
PDGFRB
|
PLCG1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
977.0
|
0.97
|
STRING
|
36370105
|
ABL1
|
CRK
|
â—¼ PHYSICAL_INTERACTION
|
|
|
978.0
|
0.97
|
STRING
|
36370105
|
SHC1
|
EGFR
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.98
|
0.98
|
mint
|
16729043
5218694
|
GRB2
|
EGFR
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.98
|
0.98
|
mint
|
16729043
5218694
|
RPTOR
|
MTOR
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.98
|
0.98
|
mint
|
24036451
|
MTOR
|
RPTOR
|
â—¼ COLOCALIZATION
|
✅
|
|
0.98
|
0.98
|
mint
|
21045808
8088164
|
HRAS
|
RAF1
|
â—¼ PROXIMITY
|
✅
|
|
0.98
|
0.98
|
mint
|
18273062
6540139
|
RAF1
|
HRAS
|
â—¼ PROXIMITY
|
✅
|
|
0.98
|
0.98
|
mint
|
18273062
6540139
|
CDK6
|
CDKN2A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
981.0
|
0.98
|
STRING
|
36370105
|
CCND1
|
CDKN1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
983.0
|
0.98
|
STRING
|
36370105
|
EGFR
|
ERBB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
983.0
|
0.98
|
STRING
|
36370105
|
MAP2K2
|
MAPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
984.0
|
0.98
|
STRING
|
36370105
|
CCND1
|
CDKN1B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
985.0
|
0.98
|
STRING
|
36370105
|
PIK3CA
|
PIK3R2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
987.0
|
0.98
|
STRING
|
36370105
|
MTOR
|
RPTOR
|
â—¼ PHOSPHORYLATION
|
✅
|
+
|
0.98
|
0.98
|
Signor
|
19346248
|
SHC1
|
GRB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.99
|
0.99
|
HIPPIE
|
12485888
21725358
31980649
9126968
7514169
7744881
8235613
11453982
8662733
8491186
7629070
8940013
10570290
8112292
12213123
11302736
8662998
8195171
7597091
8810340
32062451
9129019
16371368
12149229
10049786
8626525
7650032
8950973
9488479
24189400
15812354
12441060
19380743
26551075
22057045
10477741
28690151
16713569
7516467
9733714
11827484
11964172
7537740
16520382
9019162
8663178
9797459
9032244
12577067
9927207
7524086
8995379
9886492
8294403
7559490
9434624
11792427
7798267
8621719
9541596
15688026
12898421
33961781
11370743
25416956
9544989
22974441
8939605
21706016
9083103
7535773
11505033
9175774
24430869
10080542
9020193
9045692
10356320
15888547
9254595
8561895
11707405
8647288
|
BCL2L11
|
MCL1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
994.0
|
0.99
|
STRING
|
36370105
|
EGFR
|
SHC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
995.0
|
0.99
|
STRING
|
36370105
|
EGFR
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
MDM2
|
MDM4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
ATM
|
ABL1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
54.0
|
1.0
|
ACSN
|
11331603
11438669
11804596
11877377
12086603
12556884
12607003
14988723
15136767
15140942
15175241
15459660
15485915
15798197
15867354
15964794
16163361
16332722
16581787
16713580
16731533
16805667
16858402
17102137
17116885
17296725
17303408
17384638
17582221
17713585
18006705
18048416
18469862
18511906
18583988
18716619
18756267
18995830
19151707
19282663
19342888
19357644
19490890
19622404
19788416
19793801
19793861
19841479
20019063
20051983
21376743
23847781
9168117
9858600
|
ABL1
|
CRK
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
6.0
|
1.0
|
ACSN
|
10837221
15459660
18835194
21051857
21199784
21435002
|
ABL1
|
CRKL
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
6.0
|
1.0
|
ACSN
|
10837221
15459660
18835194
21051857
21199784
21435002
|
ATM
|
ABL1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
44.0
|
1.0
|
Omnipath
|
17145710
17303408
22334513
11375976
11804596
23331499
21071413
16163361
17570479
18988627
9168116
23847781
9168117
20798688
15964794
19788416
9561848
22084676
12607003
10212258
15459660
11877377
15686624
17409407
|
BRCA1
|
ABL1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
12919958
12024016
17352427
|
ABL1
|
IRS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
12560071
20841568
|
ABL1
|
CRK
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
100.0
|
1.0
|
Omnipath
|
8978305
9747873
9480991
19426560
17081983
23124138
16522685
16713569
20841568
18768933
8875975
25860930
21779437
19534553
16187300
17515907
21602891
16267043
20068231
10592173
17570479
8194526
7926767
11080615
25381819
12198159
9642287
15696159
18619508
18835194
11956190
22848689
11314030
9480911
19001122
19402756
20697350
12384576
24412932
7542925
11380621
12799422
19380743
12955086
17474147
17016520
|
ABL1
|
MDM4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
10.0
|
1.0
|
Omnipath
|
20651945
29262653
26148237
19075013
20841568
28690977
29348869
|
ABL1
|
CRKL
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
55.0
|
1.0
|
Omnipath
|
8978305
22581121
20841568
10837221
18768933
7493940
9710592
16955467
8524328
23331499
21199784
18794134
10592173
21051857
7926767
16443220
18835194
24165979
26500649
18809728
15459660
26192618
24412932
9053848
22286129
8083188
14604282
21435002
9820532
19823681
|
ABL1
|
PDGFRB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
14993293
19275932
20841568
|
ABL1
|
MDM2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
32.0
|
1.0
|
Omnipath
|
23331499
12110584
20651945
29065514
22352870
16702947
25973395
27626309
21081495
27956626
20841568
14757045
19738896
15212693
28690977
|
ABL1
|
CDKN1B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
11.0
|
1.0
|
Omnipath
|
17254966
17908796
22276948
16195327
|
ABL1
|
MET
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
29.0
|
1.0
|
Omnipath
|
9826708
12766170
9391119
9242692
10506185
8547236
10069803
7687741
10490849
11741535
21777671
8906793
12475979
9444958
7513258
7961992
15475459
9252406
7838524
7731718
8662889
7708691
|
ABL1
|
MTOR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
21071413
23331499
10753870
|
ABL1
|
GRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
34.0
|
1.0
|
Omnipath
|
11726515
16713569
20841568
8596638
16955467
10592173
8647802
8194526
7926767
14725908
23950177
8112292
9407116
23181695
19380743
17474147
9516488
19823681
|
ABL1
|
PLCG1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
18.0
|
1.0
|
Omnipath
|
10708759
19290927
12652307
1383690
16525023
8657103
20841568
17474147
|
ABL1
|
EGFR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
55.0
|
1.0
|
Omnipath
|
24430869
15192046
33889303
16273093
16943190
14760089
29880877
15618223
33574089
8910327
12631709
25173817
25402006
20841568
33947961
34107301
34469737
19915609
32019812
2022651
34290403
33707748
15329413
7678409
9733788
8490966
28338646
3263271
15901825
2022652
10069801
7506413
24658140
8408058
34385595
31980649
1314835
7741752
18668345
28724430
12648464
25073158
26079946
34155348
|
ABL1
|
SHC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
8617726
1623525
10194451
19380743
10592173
20841568
8112292
|
MYC
|
APC
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
22911891
12695333
|
BRCA1
|
ATM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
22021381
16153896
18923075
18805091
21325134
22792074
19419957
21052091
18971343
25122754
11301010
21240188
|
ATM
|
BRCA1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
54.0
|
1.0
|
ACSN
|
11331603
11438669
11804596
11877377
12086603
12556884
12607003
14988723
15136767
15140942
15175241
15459660
15485915
15798197
15867354
15964794
16163361
16332722
16581787
16713580
16731533
16805667
16858402
17102137
17116885
17296725
17303408
17384638
17582221
17713585
18006705
18048416
18469862
18511906
18583988
18716619
18756267
18995830
19151707
19282663
19342888
19357644
19490890
19622404
19788416
19793801
19793861
19841479
20019063
20051983
21376743
23847781
9168117
9858600
|
ATM
|
MDM2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
54.0
|
1.0
|
ACSN
|
11331603
11438669
11804596
11877377
12086603
12556884
12607003
14988723
15136767
15140942
15175241
15459660
15485915
15798197
15867354
15964794
16163361
16332722
16581787
16713580
16731533
16805667
16858402
17102137
17116885
17296725
17303408
17384638
17582221
17713585
18006705
18048416
18469862
18511906
18583988
18716619
18756267
18995830
19151707
19282663
19342888
19357644
19490890
19622404
19788416
19793801
19793861
19841479
20019063
20051983
21376743
23847781
9168117
9858600
|
ATM
|
E2F1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
22.0
|
1.0
|
Omnipath
|
20972224
11459832
27679857
15494392
15140942
27028861
21543892
27025900
20860841
24741006
17570479
25101673
28812991
15838517
22174788
|
ATM
|
MDM2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
66.0
|
1.0
|
Omnipath
|
14654783
12383858
17936559
20651945
17303408
19816404
10611322
23150762
23277204
23386996
26416444
27258263
23002429
11331603
15865937
21556066
16163361
23708100
17570479
20514355
22264782
27177180
18265945
28690977
23847781
22264786
15140942
15964794
19788416
22624716
25201202
27462439
12607003
28050229
32350255
22649771
27956626
15459660
22976441
25247188
28904407
11877377
21859827
24534650
23405218
29290977
27568562
|
ATM
|
MDM4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
25.0
|
1.0
|
Omnipath
|
20651945
16943424
29065514
16511560
20860841
28690977
17512070
23002429
16163388
16082221
28096294
15788536
|
ATM
|
RASSF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
31175105
22438769
19962312
27322327
10608806
22389451
|
ATM
|
BRCA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
79.0
|
1.0
|
Omnipath
|
26927092
17303408
15159397
24746700
12024016
10866324
30197789
12919958
11114888
26745677
26383678
34301763
12427729
11313470
16163361
28035057
20068231
25939603
26320175
17570479
19683496
22743550
10608806
23802008
23847781
21203981
15964794
12183412
12607003
17525332
19996295
15459660
11278964
19651622
21706030
11877377
20952512
10373534
19622773
10550055
27170701
15212693
23704879
|
BCL2
|
BAK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
8.0
|
1.0
|
ACSN
|
11704864
17446862
22039431
23064052
23377657
23430059
23850759
8929532
|
MCL1
|
BAK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
ACSN
|
20501829
22039431
23430059
23850759
|
BCL2
|
BAK1
|
â—¼ PROTEIN_INTERACTION
|
|
|
8.0
|
1.0
|
ACSN
|
11704864
17446862
22039431
23064052
23377657
23430059
23850759
8929532
|
MCL1
|
BAK1
|
â—¼ PROTEIN_INTERACTION
|
|
|
4.0
|
1.0
|
ACSN
|
20501829
22039431
23430059
23850759
|
MCL1
|
BAK1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
ACSN
|
20501829
22039431
23430059
23850759
|
BCL2
|
BAK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
17.0
|
1.0
|
Omnipath
|
17145710
9463381
14980220
11206074
17289999
26004684
11728179
20836993
19168699
|
BCL2L2
|
BAK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
10.0
|
1.0
|
Omnipath
|
17289999
18178565
25416956
10381646
15901672
32296183
|
MCL1
|
BAK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
33.0
|
1.0
|
Omnipath
|
17145710
18040043
17097560
22516262
26004684
19148187
15077116
19968986
23680104
27818144
15901672
10579309
10837489
21613222
20836993
26186194
17289999
32296183
15637055
26045051
20023629
|
BCL2
|
BMF
|
â—¼ PHYSICAL_INTERACTION
|
|
|
9.0
|
1.0
|
ACSN
|
11546872
11704864
17446862
22039431
23064052
23377657
23430059
23850759
8929532
|
BCL2
|
TMBIM6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
9.0
|
1.0
|
ACSN
|
11704864
17446862
22039431
23064052
23377657
23430059
23850759
8929532
9660918
|
BCL2
|
BCL2L11
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
ACSN
|
10198631
11704864
15486085
15724238
17446862
22039431
23064052
23377657
23430059
23850759
8929532
9430630
|
BCL2
|
BCL2L11
|
â—¼ PROTEIN_INTERACTION
|
|
|
12.0
|
1.0
|
ACSN
|
10198631
11704864
15486085
15724238
17446862
22039431
23064052
23377657
23430059
23850759
8929532
9430630
|
BCL2
|
BMF
|
â—¼ PROTEIN_INTERACTION
|
|
|
9.0
|
1.0
|
ACSN
|
11546872
11704864
17446862
22039431
23064052
23377657
23430059
23850759
8929532
|
BCL2
|
TMBIM6
|
â—¼ PROTEIN_INTERACTION
|
|
|
9.0
|
1.0
|
ACSN
|
11704864
17446862
22039431
23064052
23377657
23430059
23850759
8929532
9660918
|
PRKCA
|
BCL2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
8.0
|
1.0
|
ACSN
|
10677502
10679481
10871288
11323415
16492141
20027184
9115213
9738012
|
NFKB1
|
BCL2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
ACSN
|
11313951
11704864
21725609
23178297
23572150
|
BCL2
|
GRB2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
20.0
|
1.0
|
ACSN
|
11463391
11463392
11532940
11704864
12566895
12667443
14764585
15516985
17446862
19289794
19565474
22039431
23064052
23377657
23430059
23850759
24027568
8929532
9069260
9872359
|
BCL2
|
RAF1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
20.0
|
1.0
|
ACSN
|
11463391
11463392
11532940
11704864
12566895
12667443
14764585
15516985
17446862
19289794
19565474
22039431
23064052
23377657
23430059
23850759
24027568
8929532
9069260
9872359
|
MYC
|
BCL2
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
17.0
|
1.0
|
ACSN
|
11274345
11283613
11283614
11704864
17055429
17558397
17873522
20027199
20237412
20551172
20581311
20713526
21406394
2191300
22067385
25002027
28536364
|
BCL2
|
MCL1
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
8.0
|
1.0
|
ACSN
|
11704864
17446862
22039431
23064052
23377657
23430059
23850759
8929532
|
NFKB1
|
BCL2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
24.0
|
1.0
|
Omnipath
|
16254192
11567031
17673602
18031796
12835724
15120608
20332461
14978135
20446017
18566231
19259124
14739605
21503108
20103608
17098279
18158998
12032828
19233129
16022909
18761399
18987666
15934930
21224428
16453001
|
MYC
|
BCL2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
8036017
17404573
12695333
24167291
18809243
19201832
16316993
19649202
|
E2F1
|
BCL2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
17404573
11559537
12679318
|
CASP3
|
BCL2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
10409669
9395403
20139069
11948397
|
PRKCA
|
BCL2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
16.0
|
1.0
|
Omnipath
|
12039060
9115213
12213578
11323415
17610064
9738012
19117992
24212628
10677502
|
MAPK3
|
BCL2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
9115213
10669763
9735392
11323415
21785723
9738012
10677502
23272207
25826088
|
BCL2L11
|
BCL2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
38.0
|
1.0
|
Omnipath
|
17145710
9463381
16697956
9430630
17074758
17097560
19805519
18498746
26004684
14517273
10198631
21199865
20836993
26186194
15694340
17289999
17692808
11301022
23845444
21671007
9731710
|
MAPK1
|
BCL2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
29.0
|
1.0
|
Omnipath
|
9115213
10567572
12039864
10669763
15225643
11323415
21785723
9738012
11337027
10677502
23272207
|
BMF
|
BCL2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
16697956
11546872
|
CREBBP
|
BCL2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
9829964
10753867
17565603
15337521
10454566
|
MCL1
|
BCL2L11
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
ACSN
|
15486085
15724238
23430059
23850759
|
MCL1
|
BCL2L11
|
â—¼ PROTEIN_INTERACTION
|
|
|
4.0
|
1.0
|
ACSN
|
15486085
15724238
23430059
23850759
|
E2F1
|
BCL2L11
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
13.0
|
1.0
|
ACSN
|
11050388
11301023
11495903
14684737
15279786
17218262
17303408
17604722
17660363
18281283
18590585
19494111
7575488
|
MAPK3
|
BCL2L11
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
21.0
|
1.0
|
Omnipath
|
15486195
25915848
17604722
14555991
28474232
19150432
18174237
12646560
12818176
15486085
15212693
14681225
|
MAPK1
|
BCL2L11
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
17.0
|
1.0
|
Omnipath
|
15486195
17604722
14555991
28474232
19150432
12646560
16282323
12818176
17570479
15486085
15212693
|
E2F1
|
BCL2L11
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
17604722
11495903
11301023
18319725
19494111
11050388
18281283
14684737
|
BCL2L11
|
MCL1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
42.0
|
1.0
|
Omnipath
|
17145710
16697956
17097560
17525735
22516262
21507240
19622586
19148187
19150432
21199865
10837489
21613222
20836993
26859456
26186194
15694340
17389404
15989957
27013495
20074640
23245996
26045051
16213503
20085765
20159608
9731710
15014070
|
BCL2L11
|
BCL2L2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
19.0
|
1.0
|
Omnipath
|
17145710
9430630
16697956
15694340
17289999
21199865
9731710
32296183
|
BMF
|
BCL2L2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
8.0
|
1.0
|
Omnipath
|
25416956
32296183
11546872
|
BRCA1
|
E2F1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
24.0
|
1.0
|
ACSN
|
10884389
11877377
12496474
15175241
15220350
15279786
15459660
16581787
17218262
17303408
17660363
17713585
18458534
18590585
18660752
19525936
19793801
20029420
20376879
21060331
21337561
24254977
7575488
7935440
|
BRCA1
|
E2F1
|
â—¼ SHARES_COMPLEX
|
|
|
24.0
|
1.0
|
ACSN
|
10884389
11877377
12496474
15175241
15220350
15279786
15459660
16581787
17218262
17303408
17660363
17713585
18458534
18590585
18660752
19525936
19793801
20029420
20376879
21060331
21337561
24254977
7575488
7935440
|
BRCA1
|
E2F1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
24.0
|
1.0
|
ACSN
|
10884389
11877377
12496474
15175241
15220350
15279786
15459660
16581787
17218262
17303408
17660363
17713585
18458534
18590585
18660752
19525936
19793801
20029420
20376879
21060331
21337561
24254977
7575488
7935440
|
E2F1
|
BRCA1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
10660629
23285190
18660752
19466541
17106239
20068145
23108140
|
MYC
|
BRCA1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
12032322
19882681
20940401
10375022
21668996
11916966
12646176
11983916
|
BRCA1
|
SIRT1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
20160719
18851829
9000507
21407215
|
BRCA1
|
CDKN1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
9926942
11394910
10196224
18025037
21245169
16735508
12647291
|
E2F1
|
BRCA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
9244350
18660752
18319725
11278247
12697828
16713569
12909625
|
BRCA1
|
CDKN1B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
11877377
21060331
19793801
21337561
15459660
20029420
|
E2F1
|
CASP3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
18660752
12389032
18319725
|
CASP3
|
MDM2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
25241761
9278461
21726810
24842904
9840926
|
CASP3
|
CDKN1A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
25241761
9660939
10022118
9799125
|
CASP3
|
MCL1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
15014070
15713684
15637055
|
CASP3
|
IKBKB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
9367996
11741536
|
CASP3
|
ROCK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
11283607
|
NFKB1
|
CCND1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
20.0
|
1.0
|
Omnipath
|
17673602
10464245
18566231
18341653
11861406
20103608
12894581
17098279
22306268
10409765
19766095
15756023
17407600
18184402
17944672
17008396
15856023
20538607
19263436
16453001
|
MYC
|
CCND1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
7526316
21933022
17881732
12835716
14757441
19086036
8552398
19698176
19786833
18809243
18806825
8196642
11085504
|
E2F1
|
CCND1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
10504464
7929342
22768064
19876926
20220142
9584162
17998543
20655656
8618861
8137237
23078099
23543735
10594784
|
CDKN1B
|
CCND1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
17145710
9106657
10908655
17254966
25416956
7478582
|
HDAC2
|
CCND1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
8.0
|
1.0
|
Omnipath
|
21734722
17666529
15576399
22761862
22290435
19923891
20682799
15713663
|
CDKN1A
|
CCND1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
31.0
|
1.0
|
Omnipath
|
26203195
23443559
17145710
25416956
7478582
9837900
21988832
21516116
7777546
15232106
16082198
27107012
15695403
8657154
8242751
23007395
9106657
12383116
17556661
8756624
8662825
31515488
|
CDC25A
|
CCND1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
7575488
18590585
17303408
18073536
1075565
17568790
18786381
17660363
15279786
|
MYC
|
CCND1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
8425218
15121849
2006410
17873522
21406394
12584560
17558397
20551172
15814658
16908182
|
CCND1
|
CDK6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
17.0
|
1.0
|
Omnipath
|
19075005
17517622
9178893
11739795
24855949
15232106
16713569
11360184
10580009
11160398
|
CCND1
|
E2F1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
18.0
|
1.0
|
Omnipath
|
9190208
10498883
18590585
7575488
9315635
17303408
10385618
10778858
9736735
16236519
20068082
7736585
9425340
11520855
19075565
18786381
17660363
15279786
|
E2F1
|
CDC25A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
11154267
11799067
19633359
|
MYC
|
CDC25A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
8994810
10205150
11154267
9371770
14519204
15677471
17671423
|
MYC
|
CDC25A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
8425218
15121849
11602341
2006410
17873522
21406394
12584560
17558397
20551172
15814658
16908182
|
ROCK1
|
CDC25A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
14657354
|
CDC25A
|
CDK6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
7575488
18590585
17303408
18073536
1075565
17568790
23429262
18786381
17660363
15279786
|
CDC25A
|
CCNE1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
7575488
18590585
8617791
17303408
18073536
1075565
17568790
18786381
17660363
15279786
|
CDC25A
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
8.0
|
1.0
|
Omnipath
|
10373531
9230211
7744247
16189514
|
CDKN1A
|
CDK6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
14517297
17092340
9106657
18710949
24515438
20843055
|
E2F3
|
CDKN1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
17008321
10030670
22894933
17167174
15855772
|
EZH2
|
CDKN1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
21572997
21546904
24074410
21629038
22956625
|
DNMT3A
|
CDKN1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
20473858
15616584
16131836
24957603
|
MYC
|
CDKN1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
41.0
|
1.0
|
Omnipath
|
15190211
14519204
15616584
12408868
19174556
21949397
10319992
12553001
16204065
12545156
20878079
21042278
21400515
20190815
16706751
23804320
15757889
10920185
19270520
16452181
12408820
15528212
22371483
12565816
17885207
12384701
11274368
19150257
20551174
15899785
21120446
15071503
15474507
22814619
12835716
12748190
16738884
15711923
18636159
|
E2F1
|
CDKN1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
9748148
9191053
16923815
17008321
10030670
10702805
15048076
17167174
|
DNMT1
|
CDKN1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
21229291
21572997
19056828
16276353
9588214
21868513
23658227
|
MDM2
|
CDKN1A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
17373842
25241761
20086099
14633995
14761977
20308078
|
MAPK1
|
CDKN1A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
20519948
19364816
28368408
|
MYC
|
CDKN1A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
11.0
|
1.0
|
Omnipath
|
15528212
9618481
12545156
17550342
10454538
15155580
11283613
10920185
11283614
|
CDK6
|
CDKN1A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
12.0
|
1.0
|
Omnipath
|
25121590
20102411
15964852
22375140
15232106
16713569
16508017
19440234
|
PIM1
|
CDKN1A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
21.0
|
1.0
|
Omnipath
|
12431783
17855660
10753973
25121590
31575057
25749412
11756412
20647331
11779850
20307683
15001356
|
HDAC4
|
CDKN1A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
18632985
18850004
|
PRKCA
|
CDKN1A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
17855660
10753973
11756412
15851482
16055744
15001356
|
CDKN1A
|
CCND2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
17.0
|
1.0
|
Omnipath
|
23443559
26186194
25241761
27107012
8756624
15169570
25416956
16765349
31515488
16189514
32296183
|
CDKN1A
|
E2F1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
18.0
|
1.0
|
Omnipath
|
9190208
10498883
18590585
7575488
9315635
17303408
10385618
10778858
9736735
16236519
20068082
7736585
9425340
11520855
19075565
18786381
17660363
15279786
|
CDKN1A
|
CCNE2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
13.0
|
1.0
|
Omnipath
|
17145710
23443559
26186194
28514442
9840927
9840943
15232106
26496610
24358021
|
CDKN1A
|
CCNE1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
30.0
|
1.0
|
Omnipath
|
17145710
23443559
31831640
21988832
9472014
17293600
11438644
9380407
12839982
16765349
9632134
25241761
8891332
9660939
8242751
9218599
11477082
8756624
8662825
8637717
9716181
13678583
|
E2F1
|
CDKN1B
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
15713665
21840777
22955272
23393547
19077036
|
MAPK3
|
CDKN1B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
30.0
|
1.0
|
Omnipath
|
33574916
10781063
30976006
10375532
17409098
17209046
34407842
11425869
27140628
10931950
17254967
12700233
19584057
16160006
11726503
11889117
26528715
10831586
12907657
16880511
12140288
19473963
15735731
12529437
25132260
17254966
21715330
|
CCNE1
|
CDKN1B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
29.0
|
1.0
|
Omnipath
|
17145710
31831640
8978686
8684460
17293600
9632134
17254967
9311993
20837141
27175940
9488039
25241761
8891332
9660939
7753174
19470470
9218599
12529437
9192873
8756624
17254966
12501191
9891079
10393546
9716181
11940657
|
MAPK1
|
CDKN1B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
12042314
9192873
10831586
10931950
12700233
15212693
15735731
|
CDK6
|
CDKN1B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
9.0
|
1.0
|
Omnipath
|
16160006
25241761
18615582
16782892
21439954
11360184
|
CCNE2
|
CDKN1B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
17254966
9840927
9858585
9840943
|
PIM1
|
CDKN1B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
21062737
18593906
|
CDKN1B
|
CCND2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
25910212
16189514
|
CDKN1B
|
CCNE2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
17254966
9840927
9858585
9840943
|
CDKN1B
|
CCNE1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
29.0
|
1.0
|
Omnipath
|
17145710
31831640
8978686
8684460
17293600
9632134
17254967
9311993
20837141
27175940
9488039
25241761
8891332
9660939
7753174
19470470
9218599
12529437
9192873
8756624
17254966
12501191
9891079
10393546
9716181
11940657
|
MYC
|
CDKN2A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
19.0
|
1.0
|
ACSN
|
11274345
11283613
11283614
11704864
15199070
17055429
17558397
17873522
20027199
20237412
20551172
20581311
20713526
21406394
2191300
22067385
25002027
28536364
9694806
|
CDKN2A
|
CREBBP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
32284348
19273602
32601262
10821856
28985506
33043019
31597407
|
MYC
|
CDKN2A
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
19.0
|
1.0
|
ACSN
|
11274345
11283613
11283614
11704864
15199070
17055429
17558397
17873522
20027199
20237412
20551172
20581311
20713526
21406394
2191300
22067385
25002027
28536364
9694806
|
BMI1
|
CDKN2A
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
7.0
|
1.0
|
ACSN
|
15640618
17936558
20818389
21383063
21678481
21685941
22796940
|
HRAS
|
CDKN2A
|
â—¼ UP_REGULATES
|
✅
|
+
|
15.0
|
1.0
|
ACSN
|
10358164
12134164
12447393
14764585
16102570
17673906
20841469
24027568
24954210
7510700
7673236
8551221
9069260
9763606
9846483
|
MYC
|
CDKN2A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
20.0
|
1.0
|
Omnipath
|
15361884
11593429
11507042
20023701
23342141
16537449
23277542
10914736
9212167
12835716
24177224
11062467
15199070
18762810
19786833
20551174
11360201
23722468
|
E2F3
|
CDKN2A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
18663357
15175242
11883935
19340300
|
E2F1
|
CDKN2A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
19.0
|
1.0
|
Omnipath
|
11314038
12766778
20664976
10914734
16211008
10594030
11062467
11705881
11526499
15716352
19641316
21765927
22621932
19115249
11870517
12695664
20580656
15175242
17912037
|
EZH2
|
CDKN2A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
19954516
21572997
23289480
23826727
|
DNMT3B
|
CDKN2A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
23397112
18006804
22461910
17149367
21757290
|
DNMT3A
|
CDKN2A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
26350239
19786833
20620135
17490527
|
E2F2
|
CDKN2A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
18319725
11883935
|
IKBKB
|
CDKN2A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
21619050
20152798
29292732
|
E2F3
|
CDKN2A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
15177020
15175242
18319725
11883935
|
E2F1
|
CDKN2A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
11314038
16135794
11883935
12446760
18319725
15175242
11034215
|
MYC
|
CDKN2A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
17.0
|
1.0
|
Omnipath
|
15361884
9308237
10373560
17936558
12209154
12738781
17873522
11283613
21406394
9312026
15095404
17558397
20551172
19901969
19815509
10504341
|
BMI1
|
CDKN2A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
11.0
|
1.0
|
Omnipath
|
21383063
9308237
21678481
17936558
22796940
20818389
11283613
15640618
19404261
21685941
|
CDKN2A
|
MDM2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
57.0
|
1.0
|
Omnipath
|
12167711
18541670
23416275
9529249
17426254
12630860
17116689
12085228
15856024
10822382
19166854
12209154
12740913
17158541
16915296
17909018
25809483
9653180
14612427
22120712
16173922
10871849
18418067
24769896
9724636
21133853
10801444
19049976
9529248
16107876
18813780
20713054
18467333
15355988
18583933
20395212
11223036
|
CDKN2A
|
CDK6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
18.0
|
1.0
|
Omnipath
|
17881001
26186194
23602568
9751050
11739795
11556834
9380698
15232106
16713569
17955473
10491434
16915296
17909018
|
E2F3
|
E2F1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
14576826
7958836
12063292
|
E2F1
|
CCNE1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
20.0
|
1.0
|
Omnipath
|
21653699
19564413
20220142
23518498
8668155
7623816
1059478
14618416
20410059
12565705
17471231
23543735
10594784
24335704
22185819
21454377
11526499
10504464
8618861
8649818
|
E2F1
|
MYC
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
8208548
2721961
7753559
11705881
24038073
8355712
1549358
1567856
12629508
|
CDK6
|
E2F1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
18.0
|
1.0
|
Omnipath
|
9190208
10498883
18590585
7575488
9315635
17303408
10385618
10778858
9736735
16236519
20068082
7736585
9425340
11520855
19075565
18786381
17660363
15279786
|
CCND2
|
E2F1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
18.0
|
1.0
|
Omnipath
|
9190208
10498883
18590585
7575488
9315635
17303408
10385618
10778858
9736735
16236519
20068082
7736585
9425340
11520855
19075565
18786381
17660363
15279786
|
CCNE1
|
E2F1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
7575488
18590585
18687693
9315635
17303408
17660363
12006580
11420722
15279786
|
CREBBP
|
E2F1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
10753885
15126619
12748276
15123636
8932363
|
E2F1
|
EZH2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
18319725
14532106
|
PTGS2
|
EGFR
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
6.0
|
1.0
|
ACSN
|
18633355
20138012
21847358
23010081
23390297
25987127
|
EGFR
|
SHC1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
ACSN
|
10404636
20430953
23010081
25987127
28513565
|
EGFR
|
GRB2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
ACSN
|
10404636
20430953
23010081
25987127
28513565
|
NFKB1
|
EGFR
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
14678988
18367518
12469217
17881446
|
MAPK1
|
EGFR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
20.0
|
1.0
|
Omnipath
|
12556561
1651322
17081983
3138233
15901825
1939237
91332050
2543683
2115882
17192257
1651323
15302935
|
MAPK3
|
EGFR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
22.0
|
1.0
|
Omnipath
|
1651322
17081983
3138233
15901825
16785992
1939237
91332050
27531070
17570479
2543683
2115882
34086370
17192257
1651323
15302935
|
PRKCE
|
EGFR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
33.0
|
1.0
|
Omnipath
|
11447289
21749319
8321321
11313945
12359306
25402006
12040186
23830194
6321473
1860884
27016036
6090944
19568798
14585353
17496910
21386996
17942932
20692258
24658140
1556153
2984676
18042729
11940581
11185568
19615955
2987962
23205726
12845332
10816576
3379075
15567848
16488589
16793002
|
PRKCB
|
EGFR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
16.0
|
1.0
|
Omnipath
|
17496910
11940581
21386996
11447289
19615955
16488589
6321473
8321321
12845332
11313945
7805884
17570479
12040186
19568798
15567848
14585353
|
PTEN
|
EGFR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
16288286
10648629
17218262
12040186
15584861
|
PRKCA
|
EGFR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
39.0
|
1.0
|
Omnipath
|
11447289
8321321
11313945
25402006
12040186
20888375
15302935
6321473
1860884
12878187
6090944
19568798
14585353
17496910
21386996
24658140
2984676
11940581
31980649
15212693
85012702
19615955
2987962
12845332
3379075
7805884
10816576
15567848
16488589
|
PRKCG
|
EGFR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
14.0
|
1.0
|
Omnipath
|
17496910
11940581
21386996
11447289
19615955
16488589
6321473
8321321
12845332
11313945
12040186
19568798
15567848
14585353
|
EGFR
|
PLCG1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
89.0
|
1.0
|
Omnipath
|
19901323
17081983
16273093
9207933
2472219
16497976
15592455
16126727
16713569
24797263
17389395
8578591
23331499
7991458
1689310
20068231
17570479
9176240
12803489
16153436
7993895
16038803
7805859
15864276
1708307
7682059
15144186
11983899
12601080
9756944
15212693
14568990
12061819
9020117
8885868
12648464
8657103
15951569
17016520
7693694
|
EGFR
|
CRKL
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
31980649
23397142
18271526
24658140
25402006
16729043
|
EGFR
|
GRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
109.0
|
1.0
|
Omnipath
|
9544989
10595738
23956138
27059931
10026169
16273093
11726515
24697349
21596750
19289468
7518560
21706016
23799367
9050991
16317285
16713569
25402006
11370743
24797263
8647858
8887653
9416834
21278786
16799092
8662998
10229072
11896612
7592693
19509291
8810325
24189400
19836242
11960376
7506413
18271526
15657067
10085134
24658140
17242169
7510700
8940013
7650032
8810340
11084343
12577067
7527043
31980649
11408594
19531499
20124286
23178716
9886492
23181695
9020117
8479540
14679214
12648464
1322798
17991782
16729043
17971399
|
EGFR
|
PIK3R2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
17.0
|
1.0
|
Omnipath
|
17496910
31980649
23956138
19531499
16273093
24658140
11172806
1334406
25402006
|
EGFR
|
PLCG2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
31980649
25241761
16273093
24658140
17570479
25402006
|
EGFR
|
EZR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
21.0
|
1.0
|
Omnipath
|
1382070
31980649
24658140
12560083
9230083
15212693
10377409
15647376
|
EGFR
|
ERBB3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
23.0
|
1.0
|
Omnipath
|
17145710
23436906
7929151
21278786
24189400
23866081
17148612
12648464
27756321
18803307
10527633
10572067
22439932
|
EGFR
|
ERBB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
65.0
|
1.0
|
Omnipath
|
17081983
16207817
21044682
17148612
24557338
16713569
21203579
10233167
20471394
17389395
17486068
21278786
11500516
11279155
11500850
17426253
16843263
19650109
25241761
24189400
15657067
17307140
18803307
1706616
12354693
10572067
24355130
11408594
19060928
12648464
16516204
15951569
23436906
20211985
|
EGFR
|
SHC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
78.0
|
1.0
|
Omnipath
|
9544989
8808684
10595738
23956138
9388490
11350724
16273093
7542991
7681824
7518560
9710588
23799367
16713569
25402006
11370743
24797263
9742218
20935677
8887653
8034616
23331499
8662998
7542744
10049786
28065597
9130710
10635327
24189400
7506413
18271526
15657067
24658140
8810340
12577067
11196191
10766863
23178716
31980649
35384245
11408594
19531499
9756944
26551075
1623525
15951569
16729043
17956904
|
EGFR
|
CRK
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
52.0
|
1.0
|
Omnipath
|
10595738
9480991
16273093
9617486
25402006
17399949
8662907
8875975
21602891
20068231
8194526
12198159
9642287
11956190
24658140
26656091
9480911
31980649
15212693
26473374
16729043
17016520
|
EGFR
|
PIK3R3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
17496910
31980649
25241761
16273093
24658140
25402006
|
EGFR
|
MAP2K1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
12556561
15531749
|
IRS1
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
8316835
8810325
9832424
8621421
8530377
9852124
9003010
|
CD79A
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
9.0
|
1.0
|
Reactome
|
12456653
9341187
9705962
19372136
11071869
11449366
11909947
9697839
21822214
|
GRB2
|
CRKL
|
â—¼ PHYSICAL_INTERACTION
|
|
|
32.0
|
1.0
|
ACSN
|
10086337
10567412
10811803
10849428
10982827
11335727
11447289
11449354
11532940
11777939
12175651
12393695
12640133
15308668
15567848
15574420
16000375
16076871
16530705
16582911
16887996
17496910
17673906
18835194
19449109
19454690
22064427
22464172
24217602
25922287
26552706
8551221
|
GRB2
|
CRK
|
â—¼ PHYSICAL_INTERACTION
|
|
|
32.0
|
1.0
|
ACSN
|
10086337
10567412
10811803
10849428
10982827
11335727
11447289
11449354
11532940
11777939
12175651
12393695
12640133
15308668
15567848
15574420
16000375
16076871
16530705
16582911
16887996
17496910
17673906
18835194
19449109
19454690
22064427
22464172
24217602
25922287
26552706
8551221
|
GRB2
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
54.0
|
1.0
|
ACSN
|
10086337
10567412
10811803
10843677
10982827
11034387
11062502
11385609
11447289
11532940
11777939
11907067
12040186
12175651
12419216
12479806
12566895
12640133
12782630
14585353
14764585
15169888
15516985
15536084
15547943
15567848
15574420
15735649
15863030
16102570
16227978
16488589
16582911
16887996
17178906
17395718
17496910
17673906
18039929
19289794
19449109
19541618
19565474
19568798
19615955
21102635
22435554
24027568
26552706
7510700
8551221
8929532
9069260
9510155
|
GRB2
|
PLCG1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
51.0
|
1.0
|
ACSN
|
10072481
10086337
10209041
10567412
10781611
10811803
10925299
10982827
11169415
11447289
11532940
11777939
11994416
12175651
12640133
1281218
12845332
14764585
15214048
15567848
15574420
16102570
16329184
16582911
16887996
1712101
17397400
17496910
17673906
19449109
19494291
19909365
23523669
23620508
24584707
25137453
2536067
25456276
25960930
26552706
7523143
7682895
7890616
8226994
8551221
8649391
8976179
8995379
9489702
9535722
9846483
|
GRB2
|
SHC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
69.0
|
1.0
|
ACSN
|
10022831
10086337
10358164
10567412
10811803
10849428
10982827
11166270
11283723
11335727
11447289
11449354
11532940
11777939
11960372
12175651
12393695
12629515
12640133
13678960
15099563
15111329
15308668
15501236
15520864
15567848
15573129
15574420
15863030
16000375
16002046
16076871
16102570
16212621
16530705
16572188
16582911
16887996
17086423
17496910
17673906
17883421
18835194
19223473
19414323
19449109
19454690
19909365
21372296
21378271
22064427
22461508
22464172
23390297
23896411
24027568
24217602
24346288
24670066
25922287
26201938
26552706
7510700
8551221
8837607
9157999
9570538
9753319
9763606
|
GRB2
|
SHC1
|
â—¼ PROTEIN_INTERACTION
|
|
|
69.0
|
1.0
|
ACSN
|
10022831
10086337
10358164
10567412
10811803
10849428
10982827
11166270
11283723
11335727
11447289
11449354
11532940
11777939
11960372
12175651
12393695
12629515
12640133
13678960
15099563
15111329
15308668
15501236
15520864
15567848
15573129
15574420
15863030
16000375
16002046
16076871
16102570
16212621
16530705
16572188
16582911
16887996
17086423
17496910
17673906
17883421
18835194
19223473
19414323
19449109
19454690
19909365
21372296
21378271
22064427
22461508
22464172
23390297
23896411
24027568
24217602
24346288
24670066
25922287
26201938
26552706
7510700
8551221
8837607
9157999
9570538
9753319
9763606
|
GRB2
|
PLCG1
|
â—¼ SHARES_COMPLEX
|
|
|
51.0
|
1.0
|
ACSN
|
10072481
10086337
10209041
10567412
10781611
10811803
10925299
10982827
11169415
11447289
11532940
11777939
11994416
12175651
12640133
1281218
12845332
14764585
15214048
15567848
15574420
16102570
16329184
16582911
16887996
1712101
17397400
17496910
17673906
19449109
19494291
19909365
23523669
23620508
24584707
25137453
2536067
25456276
25960930
26552706
7523143
7682895
7890616
8226994
8551221
8649391
8976179
8995379
9489702
9535722
9846483
|
GRB2
|
CRKL
|
â—¼ SHARES_COMPLEX
|
|
|
32.0
|
1.0
|
ACSN
|
10086337
10567412
10811803
10849428
10982827
11335727
11447289
11449354
11532940
11777939
12175651
12393695
12640133
15308668
15567848
15574420
16000375
16076871
16530705
16582911
16887996
17496910
17673906
18835194
19449109
19454690
22064427
22464172
24217602
25922287
26552706
8551221
|
GRB2
|
CRK
|
â—¼ SHARES_COMPLEX
|
|
|
32.0
|
1.0
|
ACSN
|
10086337
10567412
10811803
10849428
10982827
11335727
11447289
11449354
11532940
11777939
12175651
12393695
12640133
15308668
15567848
15574420
16000375
16076871
16530705
16582911
16887996
17496910
17673906
18835194
19449109
19454690
22064427
22464172
24217602
25922287
26552706
8551221
|
GRB2
|
RAF1
|
â—¼ SHARES_COMPLEX
|
|
|
54.0
|
1.0
|
ACSN
|
10086337
10567412
10811803
10843677
10982827
11034387
11062502
11385609
11447289
11532940
11777939
11907067
12040186
12175651
12419216
12479806
12566895
12640133
12782630
14585353
14764585
15169888
15516985
15536084
15547943
15567848
15574420
15735649
15863030
16102570
16227978
16488589
16582911
16887996
17178906
17395718
17496910
17673906
18039929
19289794
19449109
19541618
19565474
19568798
19615955
21102635
22435554
24027568
26552706
7510700
8551221
8929532
9069260
9510155
|
HRAS
|
GRB2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
Reactome
|
19946327
11429702
11157491
18757403
21666749
21711248
18381441
19103595
21160078
9857065
20179196
|
KRAS
|
GRB2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
Reactome
|
19946327
11429702
11157491
18757403
21666749
21711248
18381441
19103595
21160078
9857065
20179196
|
IRS1
|
GRB2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
12.0
|
1.0
|
ACSN
|
10086337
10826997
12175651
12444011
12767520
16931767
17604717
19030972
21540285
22465479
24036369
8621421
|
NRAS
|
GRB2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
Reactome
|
19946327
11429702
11157491
18757403
21666749
21711248
18381441
19103595
21160078
9857065
20179196
|
GRB2
|
PLCG2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
33.0
|
1.0
|
ACSN
|
10072481
10086337
10567412
10781611
10811803
10982827
11169415
11447289
11777939
12175651
12640133
14764585
15567848
15574420
16102570
16329184
16582911
16887996
17496910
17673906
19449109
19494291
19909365
23620508
25137453
26552706
7523143
7890616
8551221
8649391
8976179
9489702
9535722
|
GRB2
|
SHC1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
69.0
|
1.0
|
ACSN
|
10022831
10086337
10358164
10567412
10811803
10849428
10982827
11166270
11283723
11335727
11447289
11449354
11532940
11777939
11960372
12175651
12393695
12629515
12640133
13678960
15099563
15111329
15308668
15501236
15520864
15567848
15573129
15574420
15863030
16000375
16002046
16076871
16102570
16212621
16530705
16572188
16582911
16887996
17086423
17496910
17673906
17883421
18835194
19223473
19414323
19449109
19454690
19909365
21372296
21378271
22064427
22461508
22464172
23390297
23896411
24027568
24217602
24346288
24670066
25922287
26201938
26552706
7510700
8551221
8837607
9157999
9570538
9753319
9763606
|
GRB2
|
PLCG1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
51.0
|
1.0
|
ACSN
|
10072481
10086337
10209041
10567412
10781611
10811803
10925299
10982827
11169415
11447289
11532940
11777939
11994416
12175651
12640133
1281218
12845332
14764585
15214048
15567848
15574420
16102570
16329184
16582911
16887996
1712101
17397400
17496910
17673906
19449109
19494291
19909365
23523669
23620508
24584707
25137453
2536067
25456276
25960930
26552706
7523143
7682895
7890616
8226994
8551221
8649391
8976179
8995379
9489702
9535722
9846483
|
PTEN
|
GRB2
|
â—¼ REGULATES
|
✅
|
|
15.0
|
1.0
|
ACSN
|
10648629
10753747
11747822
12040186
15584861
15721744
16288286
16982858
17218262
19847259
22179046
22465479
23732914
24254977
25364523
|
PDGFRB
|
GRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
7935391
16713569
7486683
|
ERBB2
|
GRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
27.0
|
1.0
|
Omnipath
|
31980649
9756944
21278786
16273093
24189400
11173924
9710588
24658140
11606575
14967450
17875712
16713569
16729043
|
PTEN
|
GRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
16288286
10648629
17218262
12040186
15584861
|
SHC1
|
GRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
198.0
|
1.0
|
Omnipath
|
8808684
9083103
8551221
9126968
8621483
25416956
9252386
8524223
7535773
8662998
11302736
11827484
8995379
9541596
9175774
10207047
7717978
17673906
7744881
11505033
10523831
24189400
9927207
7650032
8810340
9045692
23178716
19531499
15812354
9129019
10356320
12485888
9461587
8114695
7514169
9566877
8939605
16371368
15341520
7529871
10891441
10749687
7524086
26645482
8491186
10592173
10049786
9171350
11707404
7537740
15688026
8663178
19380743
11782427
9544989
16436051
9434624
16713569
21725358
11964172
17314098
11792427
8195171
1465135
12213123
8647288
12955078
10477741
11707405
12577067
9199344
10080542
8112292
7760801
10570290
11997181
7798267
16520382
10961885
8950973
21706016
9448048
8662733
11370743
8051109
9733714
8621475
9254595
8294403
10748054
8621719
8940013
12441060
22057045
7505797
24737791
20697350
9886492
18174162
18273058
8235613
7963520
7523859
|
MET
|
GRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
9660480
15546961
22128289
12475979
11063574
7511210
11439336
8662889
|
ERBB3
|
GRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
9756944
24189400
11173924
24658140
14967450
16729043
|
IRS1
|
GRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
26.0
|
1.0
|
Omnipath
|
8265614
7862167
11788580
8388384
8491186
8536716
7488107
7486683
10358772
10592173
8196603
12173038
12679424
8114695
11259577
8810325
|
IRS2
|
GRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
7559579
11788580
10358772
11305324
9852124
|
GRB2
|
PLCG1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
9281317
15953601
7629168
9020117
16713569
10940929
|
GRB2
|
HRAS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
17496910
16713569
17673906
11352655
|
MYC
|
HMOX1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
12695333
10600159
|
MAPK3
|
HNRNPK
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
10.0
|
1.0
|
Omnipath
|
11259409
16564677
11231586
|
MDM2
|
HNRNPK
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
19249676
16360036
23092970
|
HNRNPK
|
MDM2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
19249676
16360036
23092970
|
NRAS
|
MAPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
RAF1
|
MAPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
25435214
20179705
20141835
16364920
20130576
15035987
25907612
|
HRAS
|
MAPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
MAPK1
|
MAP2K2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
11802164
15239952
21779496
11802165
15260967
|
FGFR3
|
MAPK1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
19652666
12419216
18452557
12974390
|
MYC
|
MAPK1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
22789855
21933022
16596619
23617883
8013639
20144848
|
MAP2K2
|
MAPK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
68.0
|
1.0
|
Omnipath
|
21675959
11704645
9694850
17081983
7565670
12750173
19690332
12932319
11823456
18799465
15592455
11337027
18083107
21365009
12788955
11134045
19219045
17389395
9447970
15342917
23331499
19534553
17569879
7559390
23047924
8226933
8223433
17272394
15851026
15811950
19494114
18988627
18669648
11549292
23519423
19541618
18691976
1381507
16293107
17906627
11986622
19933846
8376945
19053285
16094384
11971971
17192257
11136732
11948414
8388392
7898932
9731057
11730323
18039929
11118451
19369195
12920017
15951569
15466214
10746662
|
PRKCA
|
MAPK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
11704645
12598525
19074803
8903320
9160888
|
MAP2K1
|
MAPK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
149.0
|
1.0
|
Omnipath
|
21675959
9694850
17081983
10757792
11319218
18799465
15592455
12788955
19415658
12697810
17389395
9447970
15342917
8226933
15851026
12270934
12644307
17255949
10998418
11242034
1378617
1381507
17906627
11986622
8376945
8157000
7992057
11948414
9731057
19651622
11251083
11266467
18707149
14743221
11279118
11704645
12750173
12932319
16497976
11337027
23331499
12048245
7559390
17272394
15811950
19494114
18669648
18691976
11741894
15972258
19053285
16094384
17192257
7898932
24623782
9166761
19369195
21336309
12920017
15466214
17016520
19901323
1712480
19690332
11823456
9032297
11134045
12876277
19534553
10995751
20068231
21506533
8223433
8248196
16153436
12594221
10567369
19933846
17563371
11730323
29175850
11352917
16135787
15951569
19058874
15212693
23241949
9560161
91184134
18083107
16887817
18578522
17569879
21071413
9148935
18452278
1330321
8670897
19541618
10777511
15935618
12925710
11971971
9765155
11136732
11118451
12082107
12952943
10746662
21768338
|
SHC1
|
MAPK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
10996427
23584453
|
MAPK1
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
12975377
23602568
16424009
19058874
23397142
21707490
|
MAPK1
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
43.0
|
1.0
|
Omnipath
|
17081983
18767875
15849194
19690332
11409918
14654779
23331499
23180781
8226933
20068231
18988627
21917714
18669648
19541618
18691976
16407412
19933846
9922370
15664191
8388392
19651622
10801873
8349614
18775330
9604935
|
MAPK1
|
MCL1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
12223490
18220336
15241487
25324174
16543145
18676833
|
MAPK1
|
RPTOR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
21071439
19339977
19864431
21325048
22493283
|
MAPK1
|
NRIP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
10938135
17088940
16093479
16613989
11467847
7791761
|
MAPK1
|
RPS6KA5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
46.0
|
1.0
|
Omnipath
|
20506250
15547943
18267068
15302935
12697810
11940578
12414794
17117922
23331499
21071413
23047924
20068231
16393692
9687510
17255949
15187187
19541618
19565474
17052211
15568999
19651622
14578350
11018520
15684425
11994045
11274345
|
MAPK1
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
17.0
|
1.0
|
Omnipath
|
10551811
17081983
8386367
17251036
91332050
17570479
1748630
7957875
27167001
15212693
1651323
15210690
|
MAPK1
|
IRS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
37.0
|
1.0
|
Omnipath
|
15001544
17081983
18949383
16123357
27014871
16914728
17360977
16099428
30401435
16131083
17640984
12510059
15613682
21850561
14579029
20594869
8626671
9395471
19651622
15576463
22289259
14769130
16020478
17242212
|
MAPK1
|
STIM1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
25562429
22298426
23687376
24114840
19881501
33023909
25447552
28935720
|
KRAS
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
NRAS
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
HRAS
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
RAF1
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
25435214
20179705
20141835
16364920
20130576
15035987
25907612
|
MAPK3
|
MAP2K2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
11802164
15239952
21779496
11802165
15260967
|
FGFR3
|
MAPK3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
19652666
12419216
18452557
12974390
|
MAP2K2
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
101.0
|
1.0
|
Omnipath
|
19901323
17081983
11704645
9694850
12750173
1411546
19690332
12932319
18799465
16497976
18083107
11134045
8626767
9006895
17389395
19219045
15342917
9447970
16887817
23331499
17569879
7867743
7559390
21071413
19534553
8226933
20068231
8223433
17272394
93330262
15851026
15811950
26987942
18988627
19494114
18669648
19541618
11242034
15466476
18691976
1381507
17906627
11986622
19933846
8376945
11971971
17192257
11136732
11948414
7898932
7687743
9731057
19651622
11730323
16464493
18983981
11251083
11118451
15580310
19369195
18707149
12920017
15951569
15466214
10746662
15212693
|
PRKCA
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
11704645
12598525
19074803
8903320
9160888
|
MAP2K1
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
106.0
|
1.0
|
Omnipath
|
9694850
17081983
11319218
18799465
17389395
9447970
15342917
8226933
15851026
12270934
12644307
11242034
1381507
17906627
9677429
11986622
8376945
7992057
11948414
7687743
9731057
19197339
11704645
7565670
12750173
12932319
8626767
23331499
12048245
7559390
17272394
15811950
26987942
19494114
18669648
18691976
17192257
8388392
7898932
16464493
19369195
12920017
15466214
19690332
11134045
19534553
10995751
7867743
8223433
8248196
10567369
19933846
17563371
1518847
11730323
18983981
16186792
16135787
15951569
19058874
15212693
10748187
9560161
9925641
9733512
18083107
11104681
9006895
17569879
21071413
7731720
1330321
93330262
19541618
15466476
12925710
11971971
11136732
11118451
10746662
|
MAPK3
|
RPTOR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
21757713
21071439
19339977
19864431
|
MAPK3
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
23331499
18463697
9155018
21071413
32482868
18988627
15210690
|
MAPK3
|
NRIP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
10938135
17088940
16093479
16613989
11467847
7791761
|
MAPK3
|
RPS6KA5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
33.0
|
1.0
|
Omnipath
|
20506250
15547943
15302935
12697810
12414794
17117922
20068231
16393692
19251839
17255949
15187187
19541618
19565474
18813292
17052211
15568999
19651622
14578350
11891214
11018520
15684425
11994045
11274345
|
MAPK3
|
IRS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
15.0
|
1.0
|
Omnipath
|
15001544
16131083
8626671
14769130
9335553
15613682
12510059
15212693
9395471
14579029
|
MAPK3
|
MCL1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
15241487
21507240
25324174
16543145
18676833
|
MAPK3
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
14654779
23331499
19541618
18691976
16407412
19933846
9446616
9922370
15664191
18988627
|
MCL1
|
IKBKB
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
13.0
|
1.0
|
ACSN
|
11274345
12847084
15592525
17462996
18641653
19392652
19509052
21133840
21232017
23430059
23850759
24378531
26587781
|
BMF
|
MCL1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
16697956
11546872
|
MYC
|
MDM2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
15655352
12695333
19649205
10348347
|
PIM1
|
MDM2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
19166854
18467333
|
MDM2
|
MDM4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
69.0
|
1.0
|
Omnipath
|
17145710
10218570
17616658
16511560
22266850
12874296
21925390
25825738
21988832
25512388
16227609
22493164
22902369
25659040
18219319
12963717
15604276
18566590
12370303
19838211
26359458
27617579
25809483
34551723
10608892
23028042
22120712
25703327
12860999
32300648
16055726
24813712
17301054
12483531
23671280
17159902
27621617
25105592
20484049
20724842
27215386
10827196
26001071
11606419
23946421
19683495
20705607
24755078
25384516
20473904
12393902
|
MTOR
|
RPTOR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
72.0
|
1.0
|
ACSN
|
10702316
11108711
11274345
11756498
12150925
12408816
12533512
12709531
12713446
12844354
12867079
12906785
15314020
15749884
15755954
15905173
16286006
16469695
16679021
16713974
16915281
17052453
17053147
17368478
17404308
17604271
17680028
18000759
18046414
18048642
18372248
18391071
18423201
18492954
19022819
19143636
19151919
19225151
19244117
19339977
19446321
19568798
19597330
19706736
19720745
19864431
19930715
20138985
20547845
20647036
20805416
20832730
20932932
21157483
21177869
21233202
21474067
21981924
22504639
23087689
24795729
24973821
25002027
25682865
25730849
26159692
26597054
27328425
27331412
27510662
27572739
28216025
|
MTOR
|
RPTOR
|
â—¼ SHARES_COMPLEX
|
|
|
72.0
|
1.0
|
ACSN
|
10702316
11108711
11274345
11756498
12150925
12408816
12533512
12709531
12713446
12844354
12867079
12906785
15314020
15749884
15755954
15905173
16286006
16469695
16679021
16713974
16915281
17052453
17053147
17368478
17404308
17604271
17680028
18000759
18046414
18048642
18372248
18391071
18423201
18492954
19022819
19143636
19151919
19225151
19244117
19339977
19446321
19568798
19597330
19706736
19720745
19864431
19930715
20138985
20547845
20647036
20805416
20832730
20932932
21157483
21177869
21233202
21474067
21981924
22504639
23087689
24795729
24973821
25002027
25682865
25730849
26159692
26597054
27328425
27331412
27510662
27572739
28216025
|
PRKCA
|
MTOR
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
6.0
|
1.0
|
ACSN
|
10679481
10871288
16492141
18851840
20027184
21474067
|
MTOR
|
RPTOR
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
72.0
|
1.0
|
ACSN
|
10702316
11108711
11274345
11756498
12150925
12408816
12533512
12709531
12713446
12844354
12867079
12906785
15314020
15749884
15755954
15905173
16286006
16469695
16679021
16713974
16915281
17052453
17053147
17368478
17404308
17604271
17680028
18000759
18046414
18048642
18372248
18391071
18423201
18492954
19022819
19143636
19151919
19225151
19244117
19339977
19446321
19568798
19597330
19706736
19720745
19864431
19930715
20138985
20547845
20647036
20805416
20832730
20932932
21157483
21177869
21233202
21474067
21981924
22504639
23087689
24795729
24973821
25002027
25682865
25730849
26159692
26597054
27328425
27331412
27510662
27572739
28216025
|
MTOR
|
MYC
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
23.0
|
1.0
|
ACSN
|
12150925
12408816
12906785
15755954
16469695
17604271
17680028
18372248
18492954
19022819
19446321
19568798
19706736
19864431
21157483
21981924
23087689
24795729
24973821
25002027
25730849
26159692
28216025
|
MTOR
|
RPTOR
|
â—¼ LOCALISATION
|
✅
|
|
72.0
|
1.0
|
ACSN
|
10702316
11108711
11274345
11756498
12150925
12408816
12533512
12709531
12713446
12844354
12867079
12906785
15314020
15749884
15755954
15905173
16286006
16469695
16679021
16713974
16915281
17052453
17053147
17368478
17404308
17604271
17680028
18000759
18046414
18048642
18372248
18391071
18423201
18492954
19022819
19143636
19151919
19225151
19244117
19339977
19446321
19568798
19597330
19706736
19720745
19864431
19930715
20138985
20547845
20647036
20805416
20832730
20932932
21157483
21177869
21233202
21474067
21981924
22504639
23087689
24795729
24973821
25002027
25682865
25730849
26159692
26597054
27328425
27331412
27510662
27572739
28216025
|
RPTOR
|
MTOR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
139.0
|
1.0
|
Omnipath
|
15268862
24403073
20427287
22258093
21321085
19446321
15467718
19875983
17461779
12665511
12719976
16631613
21045808
21177249
23911927
24337580
25446900
24516643
18614546
12718876
12747827
16603397
17043309
18519641
22544753
25007995
27043084
19145465
23953116
19619545
16919458
24375676
15459249
16837165
16847060
25332233
12150926
22424946
26348909
12150925
18955708
20381137
22356909
17386266
17565979
18030348
16354680
20169205
19114562
21071439
27329724
35561222
16798736
15809305
22493283
17277771
15661536
16962653
1683716516603397
17604271
18676370
16183647
18505677
23297343
23872070
24036451
15066126
18570873
21614075
18722121
12408816
17599906
|
MTOR
|
IRS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
15.0
|
1.0
|
Omnipath
|
22570710
15952059
19561084
21282364
25973388
14769130
11287630
9335553
17698034
20863384
|
NFKB1
|
MYC
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
6.0
|
1.0
|
ACSN
|
18490439
19219071
21725609
2191300
23178297
23572150
|
RPTOR
|
MYC
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
23.0
|
1.0
|
ACSN
|
12150925
12408816
12906785
15755954
16469695
17604271
17680028
18372248
18492954
19022819
19446321
19568798
19706736
19864431
21157483
21981924
23087689
24795729
24973821
25002027
25730849
26159692
28216025
|
MYC
|
GLS
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
13.0
|
1.0
|
ACSN
|
11274345
11283614
17558397
17873522
20027199
20237412
20551172
20581311
20713526
21406394
2191300
22067385
25002027
|
MYC
|
BMI1
|
â—¼ UP_REGULATES
|
✅
|
+
|
32.0
|
1.0
|
ACSN
|
11274345
11283614
12545156
14536078
15147722
15155580
15279786
17055429
17303408
17550342
17558397
17660363
17873522
18590585
18636226
20027199
20237412
20551172
20581311
20713526
20818389
21406394
21733352
2191300
21919891
22067385
23140366
23869868
25002027
28536364
7575488
9618481
|
NFKB1
|
MYC
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
12894581
18184402
7869034
17673602
12783888
11114727
17944672
9596659
12504005
19469019
21790895
19766095
17018379
8289784
18566231
1515224
|
MYC
|
CCNE1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
18802399
20607601
14519204
22583478
9188852
11983916
11509615
|
MYC
|
CCND2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
7526316
11511535
10508165
9339900
15988028
20857481
11060032
14519204
14660677
10956386
21790895
11264343
|
MYC
|
PTEN
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
23135913
19578399
12695333
|
MYC
|
ERBB2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
20920219
21627565
7906953
23421821
20716114
|
MYC
|
IGF2BP1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
21779431
18414489
21252116
|
MYC
|
CDK6
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
20682794
22395148
12835716
|
CREBBP
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
10.0
|
1.0
|
Omnipath
|
7575488
18590585
17303408
15522869
12776737
20144767
17660363
16878156
15279786
|
PIM1
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
25749412
28505071
25280219
27775704
18438430
29472550
|
MAPK7
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
22046506
9461566
|
MYC
|
CCND2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
8425218
15121849
11602341
2006410
17873522
21406394
12584560
17558397
20551172
15814658
16908182
|
HRAS
|
RASSF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
16810318
17145710
18596699
32814053
10998413
|
CCND2
|
CDK6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
10477583
17517622
16713569
|
MET
|
CRKL
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
10871282
12138161
11146548
10753869
10618718
|
CRK
|
CRKL
|
â—¼ PHYSICAL_INTERACTION
|
|
|
84.0
|
1.0
|
ACSN
|
10022831
10086337
10426994
10567412
10811803
10849428
10982827
11062502
11166270
11335727
11353765
11385609
11447289
11449354
11526404
11532940
11579131
11687500
11777939
11907067
11960372
12175651
12393695
12629515
12640133
12670391
13678960
15099563
15111329
15169881
15308668
15501236
15520864
15536084
15567848
15573129
15574420
16000375
16002046
16076871
16530705
16572188
16582911
16713974
16887996
17086423
17397400
17496910
17673906
17883421
18250477
18287025
18835194
19109239
19414323
19449109
19454690
19909365
20189481
20805416
21149606
21372296
21826665
22064427
22461508
22464172
23087689
23390297
23523669
24217602
24346288
24751819
24795729
25922287
25960930
26201938
26552706
7682895
8551221
8837607
9157999
9314552
9570538
9753319
|
SHC1
|
CRKL
|
â—¼ PHYSICAL_INTERACTION
|
|
|
32.0
|
1.0
|
ACSN
|
10086337
10567412
10811803
10849428
10982827
11335727
11447289
11449354
11532940
11777939
12175651
12393695
12640133
15308668
15567848
15574420
16000375
16076871
16530705
16582911
16887996
17496910
17673906
18835194
19449109
19454690
22064427
22464172
24217602
25922287
26552706
8551221
|
CRK
|
CRKL
|
â—¼ SHARES_COMPLEX
|
|
|
84.0
|
1.0
|
ACSN
|
10022831
10086337
10426994
10567412
10811803
10849428
10982827
11062502
11166270
11335727
11353765
11385609
11447289
11449354
11526404
11532940
11579131
11687500
11777939
11907067
11960372
12175651
12393695
12629515
12640133
12670391
13678960
15099563
15111329
15169881
15308668
15501236
15520864
15536084
15567848
15573129
15574420
16000375
16002046
16076871
16530705
16572188
16582911
16713974
16887996
17086423
17397400
17496910
17673906
17883421
18250477
18287025
18835194
19109239
19414323
19449109
19454690
19909365
20189481
20805416
21149606
21372296
21826665
22064427
22461508
22464172
23087689
23390297
23523669
24217602
24346288
24751819
24795729
25922287
25960930
26201938
26552706
7682895
8551221
8837607
9157999
9314552
9570538
9753319
|
SHC1
|
CRKL
|
â—¼ SHARES_COMPLEX
|
|
|
32.0
|
1.0
|
ACSN
|
10086337
10567412
10811803
10849428
10982827
11335727
11447289
11449354
11532940
11777939
12175651
12393695
12640133
15308668
15567848
15574420
16000375
16076871
16530705
16582911
16887996
17496910
17673906
18835194
19449109
19454690
22064427
22464172
24217602
25922287
26552706
8551221
|
CRK
|
CRKL
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
84.0
|
1.0
|
ACSN
|
10022831
10086337
10426994
10567412
10811803
10849428
10982827
11062502
11166270
11335727
11353765
11385609
11447289
11449354
11526404
11532940
11579131
11687500
11777939
11907067
11960372
12175651
12393695
12629515
12640133
12670391
13678960
15099563
15111329
15169881
15308668
15501236
15520864
15536084
15567848
15573129
15574420
16000375
16002046
16076871
16530705
16572188
16582911
16713974
16887996
17086423
17397400
17496910
17673906
17883421
18250477
18287025
18835194
19109239
19414323
19449109
19454690
19909365
20189481
20805416
21149606
21372296
21826665
22064427
22461508
22464172
23087689
23390297
23523669
24217602
24346288
24751819
24795729
25922287
25960930
26201938
26552706
7682895
8551221
8837607
9157999
9314552
9570538
9753319
|
CRKL
|
PIK3R2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
9092574
9461587
11553620
|
PRKCA
|
EZR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
20.0
|
1.0
|
Omnipath
|
14504278
15531580
10970850
11387207
21899702
15843435
9516463
15647376
|
ROCK1
|
EZR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
32.0
|
1.0
|
Omnipath
|
8522586
9856983
14504278
15531580
9287351
10970850
12778124
12045227
11387207
19255442
15843435
12802084
7579708
19386264
10047517
8527459
|
FGFR3
|
SHC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
9045692
9480847
18840094
7559490
|
SHC1
|
CRK
|
â—¼ PHYSICAL_INTERACTION
|
|
|
32.0
|
1.0
|
ACSN
|
10086337
10567412
10811803
10849428
10982827
11335727
11447289
11449354
11532940
11777939
12175651
12393695
12640133
15308668
15567848
15574420
16000375
16076871
16530705
16582911
16887996
17496910
17673906
18835194
19449109
19454690
22064427
22464172
24217602
25922287
26552706
8551221
|
SHC1
|
CRK
|
â—¼ SHARES_COMPLEX
|
|
|
32.0
|
1.0
|
ACSN
|
10086337
10567412
10811803
10849428
10982827
11335727
11447289
11449354
11532940
11777939
12175651
12393695
12640133
15308668
15567848
15574420
16000375
16076871
16530705
16582911
16887996
17496910
17673906
18835194
19449109
19454690
22064427
22464172
24217602
25922287
26552706
8551221
|
SHC1
|
PLCG1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
52.0
|
1.0
|
ACSN
|
10022831
10086337
10567412
10811803
10849428
10982827
11166270
11447289
11449354
11532940
11777939
11960372
12175651
12393695
12629515
12640133
13678960
15099563
15111329
15501236
15520864
15567848
15573129
15574420
16002046
16076871
16572188
16582911
16887996
17086423
17496910
17673906
17883421
19414323
19449109
21372296
21378271
22064427
22461508
23390297
23896411
24217602
24346288
24670066
25922287
26201938
26552706
8551221
8837607
9157999
9570538
9753319
|
ERBB2
|
SHC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
27.0
|
1.0
|
Omnipath
|
28065597
23331499
9756944
16273093
8026468
9710588
10085134
24658140
9590694
16713569
16729043
16843263
|
PDGFRA
|
SHC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
20.0
|
1.0
|
Omnipath
|
15592455
9121430
9446569
12767520
10921922
10482988
10764799
17673906
17496910
12522270
9685404
10896916
9927207
8702728
12237775
8610109
9741627
9710204
10816433
11075717
|
IRS1
|
SHC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
23331499
9202037
10807918
7499194
|
ERBB3
|
SHC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
19.0
|
1.0
|
Omnipath
|
9694850
9756944
16273093
24189400
8026468
24658140
9590694
16189514
16729043
|
PRKCA
|
SHC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
12052829
19651622
18669648
17924679
|
MET
|
SHC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
9083103
11687594
9660480
14990987
24728074
8084588
8939605
8947042
7731718
11884620
15688026
14685170
|
PDGFRB
|
SHC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
26.0
|
1.0
|
Omnipath
|
15592455
9121430
16713569
9446569
12767520
23331499
21071413
10921922
10482988
10764799
8195171
17673906
17496910
12522270
9685404
10896916
9927207
8702728
12237775
8610109
9741627
9710204
10816433
11075717
|
PDGFRB
|
CRK
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
23331499
19426560
10733900
16713569
27686861
|
IRS1
|
CRK
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
9837978
8810325
8621590
|
PDGFRA
|
CRK
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
23331499
19426560
25241761
10733900
16713569
9546424
27686861
|
CRK
|
PIK3R3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
25814554
35044719
19380743
|
CRK
|
PIK3R2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
35044719
19380743
25814554
11418612
|
PDGFB
|
PDGFRB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
ACSN
|
15099563
17145802
17496910
18633355
24359404
|
PDGFRB
|
PDGFRA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
ACSN
|
15099563
17145802
17496910
18633355
24359404
|
PDGFB
|
PDGFRB
|
â—¼ SHARES_COMPLEX
|
|
|
5.0
|
1.0
|
ACSN
|
15099563
17145802
17496910
18633355
24359404
|
PDGFRB
|
PDGFRA
|
â—¼ SHARES_COMPLEX
|
|
|
5.0
|
1.0
|
ACSN
|
15099563
17145802
17496910
18633355
24359404
|
PDGFA
|
PDGFRB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
15207812
25737405
7679113
|
PDGFB
|
PDGFRB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
28.0
|
1.0
|
Omnipath
|
9739761
20577048
30150707
16189514
15207812
28267575
7679113
11297552
15207811
20534510
17981115
10806482
285049611903042
11903042
11331882
2850496
|
PDGFRB
|
PLCG1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
34.0
|
1.0
|
Omnipath
|
17081983
7486683
2472219
16126727
15592455
7535778
16713569
23331499
1689310
11896612
15641795
16153436
16038803
23063561
1708307
7682059
15144186
12601080
1396585
8885868
8657103
8443409
23397142
15212693
|
PDGFRB
|
PDGFRA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
17.0
|
1.0
|
Omnipath
|
23331499
21071413
2161888
2542288
7523122
1847074
16189514
11331882
10417313
|
PDGFB
|
PDGFA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
9334164
10508235
1311092
8900172
|
PDGFB
|
PDGFRA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
ACSN
|
15099563
17145802
17496910
18633355
24359404
|
PDGFB
|
PDGFRA
|
â—¼ SHARES_COMPLEX
|
|
|
5.0
|
1.0
|
ACSN
|
15099563
17145802
17496910
18633355
24359404
|
PDGFB
|
PDGFRA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
27.0
|
1.0
|
Omnipath
|
9739761
15767546
152078112544881
23331499
21071413
16189514
18988627
15207812
28267575
7679113
15207811
2544881
11297552
9677323
10806482
11331882
11803579
|
PLCG1
|
FGFR3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
19147536
16091734
10652257
10918587
19749790
18337450
16844695
|
ERBB2
|
PLCG1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
23331499
16273093
1676673
1683701
|
PRKCA
|
PLCG1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
2820980
8885868
10592173
1370476
|
FGFR3
|
PLCG1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
17496910
12601080
17081983
16038803
1689310
1708307
7682059
15144186
8885868
16126727
15592455
8657103
16153436
|
RHOA
|
PLCG1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
23331499
12071848
|
PDGFRA
|
PLCG1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
18.0
|
1.0
|
Omnipath
|
23331499
12601080
17081983
16038803
25241761
1689310
1708307
7682059
15144186
8885868
16126727
15592455
7535778
8657103
16153436
|
ROCK1
|
PTEN
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
8.0
|
1.0
|
ACSN
|
10652353
11698448
12194823
12778124
19349987
20008297
22074495
27785353
|
RHOA
|
PTEN
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
32.0
|
1.0
|
ACSN
|
10953004
11698448
11729192
11739775
11992112
12194823
12361600
12740575
12778124
14657501
14744429
15761148
15793569
17517963
18037882
18423981
20008297
20351293
20535745
21178402
21642958
21840487
22949611
24857661
24919149
26885855
27048821
27066895
7479854
9362522
9660866
9822605
|
ROCK1
|
PTEN
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
20008297
22074495
24867289
15793569
21642958
26460959
20351293
|
PTEN
|
PIK3CA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
16288286
10648629
17218262
12040186
15584861
|
HRAS
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
999.0
|
1.0
|
STRING
|
36370105
|
RAF1
|
HRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
14.0
|
1.0
|
ACSN
|
10358164
11532940
12566895
14764585
15516985
16102570
19289794
19565474
24027568
7510700
8551221
9069260
9763606
9846483
|
RAF1
|
HRAS
|
â—¼ SHARES_COMPLEX
|
|
|
14.0
|
1.0
|
ACSN
|
10358164
11532940
12566895
14764585
15516985
16102570
19289794
19565474
24027568
7510700
8551221
9069260
9763606
9846483
|
RAF1
|
HRAS
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
14.0
|
1.0
|
ACSN
|
10358164
11532940
12566895
14764585
15516985
16102570
19289794
19565474
24027568
7510700
8551221
9069260
9763606
9846483
|
KRAS
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
53.0
|
1.0
|
Omnipath
|
10958680
12750173
9516156
12932319
9665134
10783161
8805624
1386920
1639773
8340422
8601312
19595761
23331499
16041367
21071413
8332195
9446616
10882715
25852190
10531446
1996324
19029954
8503013
16093354
19541618
23153539
16293107
1708096
19933846
26721396
11136732
10205168
20802526
31980649
7760835
18775988
8307946
12917261
11134016
20080631
8180183
1990291
|
HRAS
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
147.0
|
1.0
|
Omnipath
|
17145710
18273062
9523700
1639773
8601312
19595761
20133694
11032808
9154803
10882715
14654780
1996324
19222999
16301319
11948414
8530446
7969158
11313862
9150145
20080631
1990291
12750173
15031288
12932319
9665134
8805624
8340422
1386920
23331499
16916524
16041367
23180781
18988627
20178605
15688026
15664191
22169110
11733498
7862125
8180183
19063885
12391160
9144171
8035810
9020159
14724584
19696784
21779497
9261098
12173045
12620389
8628317
19914712
1708096
19933846
26721396
7730360
10205168
8332187
16803888
18775988
12917261
9099670
10545207
25684575
8670882
10783161
12379659
10887184
17569879
21071413
8332195
7523381
10531446
24929361
8503013
16093354
19541618
10369681
8911690
18073111
11136732
10922060
7760835
11134016
|
PRKCG
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
8288587
17053865
|
PRKCB
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
8288587
1386920
12917261
22826029
|
PRKCA
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
27.0
|
1.0
|
Omnipath
|
1386920
23331499
9447975
8321321
12551925
8288587
7935389
12917261
9922370
15664191
93309588
1437148
|
NRAS
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
46.0
|
1.0
|
Omnipath
|
9867809
12750173
12932319
9001246
9665134
8805624
1386920
1639773
8340422
8601312
19595761
23331499
21071413
8332195
10531446
10882715
7811320
1996324
18988627
21779497
8636091
8503013
7766599
16093354
19541618
8180183
1708096
19933846
32296183
9525741
8876196
11136732
10205168
21478863
7760835
18775988
12917261
11134016
18641128
20080631
9488663
1990291
|
RAF1
|
MAP2K2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
47.0
|
1.0
|
Omnipath
|
7565670
12750173
18799465
16364241
11909642
19219045
21988832
23331499
15342917
8933152
9671314
8393135
9808624
8223433
16189514
18988627
18669648
19541618
16293107
10969079
10567369
8157000
11136732
11948414
7898932
9069260
18039929
19369195
8607979
10327068
17116858
24746704
12920017
16129686
19058874
15466214
|
RAF1
|
MAP2K1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
143.0
|
1.0
|
Omnipath
|
10757792
18337766
18799465
15342917
23728975
26496610
15866172
17053865
11242034
9351825
9677429
8157000
7992057
11948414
11604401
16129686
10677502
12695496
19197339
7565670
12750173
7936666
1326789
19219045
23331499
18556463
10976102
18988627
15485920
15175348
18691976
16407412
10409742
9311917
17192257
7898932
8621729
23934108
11684694
21336309
7624324
12920017
11948406
15466214
11042690
12907640
9032297
27169363
12876277
8933152
8223433
8248196
8131746
12594221
10969079
10567369
17979178
17724343
24746704
19058874
10958680
8090753
21071413
7731720
7873542
1330321
8503013
16093354
19541618
8394352
15466476
25155755
11136732
9069260
94178255
8607979
10327068
10359597
8039496
20212043
|
PIK3R2
|
HRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
31135801
24897931
8665852
17998941
11136978
21779505
8052307
12121613
1716764
26085527
21779497
12094235
|
HRAS
|
PIK3CB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
31135801
24897931
8665852
17998941
11136978
21779505
8052307
12121613
1716764
26085527
21779497
12094235
|
HRAS
|
MAP2K2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
HRAS
|
ZDHHC9
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
29311131
21779505
2661017
16000296
|
HRAS
|
ERBB3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
12.0
|
1.0
|
Reactome
|
23220880
25853726
30301790
28274957
18039657
16843263
25994018
26545934
22046346
18413839
23948973
26375550
|
HRAS
|
PIK3CD
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
9069260
9113989
9235916
21779497
11739523
10545207
|
HRAS
|
PIK3CA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
20.0
|
1.0
|
Omnipath
|
9069260
9113989
8052307
24412244
17540175
9931431
11313862
14724584
10592173
9150145
8665852
10783161
|
HDAC2
|
EZH2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
8.0
|
1.0
|
ACSN
|
15465827
17018611
17563753
21234400
21577210
21685935
22514743
22796940
|
HDAC2
|
EZH2
|
â—¼ SHARES_COMPLEX
|
|
|
8.0
|
1.0
|
ACSN
|
15465827
17018611
17563753
21234400
21577210
21685935
22514743
22796940
|
RHOA
|
ROCK1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
25.0
|
1.0
|
ACSN
|
11698448
11729192
11739775
11992112
12194823
12361600
12740575
14657501
14744429
15761148
17517963
18037882
18423981
20535745
21178402
22949611
24857661
24919149
26885855
27048821
27066895
7479854
9362522
9660866
9822605
|
RHOA
|
ROCK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
55.0
|
1.0
|
Omnipath
|
17145710
12361600
25010901
23151663
7479854
27048821
22949611
21281639
26885855
8798490
12727213
17673200
11729192
8816443
10592173
11698448
27066895
11739775
11992112
20535745
18423981
24857661
21178402
23109003
9660866
9822605
17517963
14660612
15774750
12740575
14744429
9535835
12773565
15761148
24919149
26192618
9362522
18037882
14657501
12194823
|
RHOB
|
ROCK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
11283606
15699075
8816443
11294240
8617235
|
ROCK1
|
RDX
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
20.0
|
1.0
|
Omnipath
|
17447891
8522586
9456324
9287351
10970850
12778124
12045227
20068231
12802084
7579708
10047517
8527459
|
NFKB1
|
PTGS2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
33.0
|
1.0
|
Omnipath
|
9266823
20669087
12471036
17673602
10827178
16210649
12466023
15517885
12622742
18294142
19618291
12067569
15655349
17556653
9988750
18973191
14988266
12871860
20103608
15555528
11082190
15234907
22001128
16820889
19766095
15997464
12349897
15387324
15368354
18057724
15547942
16624933
17767925
|
PRKCA
|
IRS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
10.0
|
1.0
|
Omnipath
|
22869320
15364919
16574739
17570479
15516986
15069075
|
IKBKB
|
IRS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
30.0
|
1.0
|
Omnipath
|
10722755
19651622
24337154
18443205
23050932
15199052
20953398
25381390
16129690
29767231
11606564
18077418
14583092
15613682
16099428
12351658
|
IRS1
|
PIK3CD
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
12767520
10826997
12444011
21540285
19030972
16931767
12175651
|
IRS1
|
PIK3R2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
12767520
10826997
12444011
21540285
19030972
11120660
7559478
10358772
16931767
12730242
12175651
7499365
15316008
|
IRS1
|
PIK3R3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
12767520
10826997
12444011
21540285
19030972
9415396
16931767
12175651
10417350
7542745
25814554
|
IRS1
|
PIK3CA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
23.0
|
1.0
|
Omnipath
|
12767520
10826997
12444011
21540285
19030972
16354680
16150444
16931767
10592173
12175651
1380456
23643389
1381348
11313948
9374521
20966354
9624169
|
IRS1
|
PIK3CB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
12767520
10826997
12444011
21540285
19030972
16931767
14623899
11416002
12175651
|
RPS6KA5
|
NFKB1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
Reactome
|
17462920
12628924
19197368
19122653
18385332
|
IKBKB
|
NFKB1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
Reactome
|
9315679
9914500
9721103
10593898
9135156
|
NFKB1
|
E2F3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
ACSN
|
14627988
21725609
23178297
23572150
|
NFKB1
|
CD40
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
17513725
11313274
19164127
11027342
17031478
9733827
|
IKBKB
|
NFKB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
57.0
|
1.0
|
Omnipath
|
31598684
11976329
16713569
10469655
29485707
26999213
12842894
10835356
27187478
27402796
18782567
27554194
12482991
25241761
10022904
15199157
19519322
15489227
19250910
15212693
11158290
11297557
|
PRKCA
|
MARCKS
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
6.0
|
1.0
|
Reactome
|
1527003
7989336
9808756
11588141
8132675
17081983
|
PRKCA
|
MET
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
21.0
|
1.0
|
Omnipath
|
17496910
11940581
21386996
15075332
11447289
19615955
8294430
16488589
6321473
8321321
12845332
11313945
17570479
94124523
12040186
19568798
15567848
14585353
|
PRKCA
|
MARCKS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
79.0
|
1.0
|
Omnipath
|
17081983
20166139
18767875
17322306
1650359
11162562
1560845
19413330
19664995
8034575
6957862
21762971
18578522
91317794
20068231
11930178
18452278
17570479
16116087
18491316
18669648
17962038
8557118
17287340
15316066
8422248
19651622
20058876
15239673
17924679
2473066
19664994
18707149
18510355
15212693
18212344
|
PRKCA
|
KRAS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
20802526
34333552
23331499
25713064
27791178
18458061
9922370
18182391
16483930
|
PRKCA
|
ERBB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
16.0
|
1.0
|
Omnipath
|
17496910
11940581
21386996
11447289
19615955
16488589
6321473
8321321
12845332
11313945
18799465
9855018
12040186
19568798
15567848
14585353
|
MAVS
|
IKBKB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
17145710
16177806
16153868
21903422
17468758
18207245
|
PRKCE
|
IKBKB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
26.0
|
1.0
|
Omnipath
|
10823818
20448038
17595324
21673972
16267042
20068038
24290981
14514672
27585591
24386391
11325957
23123196
10195894
16735506
25486864
24833394
18266467
10022904
17975552
26195767
20450893
18930133
11460167
9346484
26998110
|
IRS2
|
PIK3R2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
10594015
19109239
9651378
15715521
|
IRS2
|
PIK3CA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
9113989
22810696
9374521
|
PRKCE
|
MET
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
22.0
|
1.0
|
Omnipath
|
11447289
8321321
11313945
94124523
12040186
7925482
6321473
15567848
19568798
14585353
17496910
21386996
8294430
11940581
15075332
19615955
12845332
15212693
16488589
|
PIK3R3
|
PIK3CA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
8596638
22402981
9415396
11733063
26496610
25814554
|
NRAS
|
PIK3CA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
8052307
7820549
9150145
8665852
21779497
|
KRAS
|
MAP2K1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
NRAS
|
MAP2K1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
PRKCB
|
ERBB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
15.0
|
1.0
|
Omnipath
|
17496910
11940581
21386996
11447289
19615955
16488589
6321473
8321321
12845332
11313945
17570479
12040186
19568798
15567848
14585353
|
ERBB2
|
PLCG2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
16273093
25241761
|
ERBB2
|
PIK3R2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
17496910
16273093
1334406
16729043
|
ERBB2
|
ERBB3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
44.0
|
1.0
|
Omnipath
|
17145710
23680147
17148612
24557338
19411071
21203579
7592681
23688700
23331499
21278786
12648465
22806884
27531070
17570479
30898150
29066975
17426253
16843263
9130710
20227043
25241761
10799311
8816440
22733765
10572067
19060928
11173924
21075308
23436906
7538656
15504738
|
KRAS
|
MAP2K2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
NRAS
|
PIK3CB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
31135801
24897931
8665852
17998941
11136978
21779505
8052307
12121613
1716764
26085527
21779497
12094235
|
KRAS
|
PIK3CB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
31135801
24897931
8665852
17998941
11136978
21779505
8052307
12121613
1716764
26085527
21779497
12094235
|
PIK3R3
|
PIK3CB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
8596638
22402981
11733063
25814554
|
PIK3R2
|
KRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
31135801
24897931
8665852
17998941
11136978
21779505
8052307
12121613
1716764
26085527
21779497
12094235
|
KRAS
|
ZDHHC9
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
29311131
21779505
2661017
16000296
|
KRAS
|
ERBB3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
12.0
|
1.0
|
Reactome
|
23220880
25853726
30301790
28274957
18039657
16843263
25994018
26545934
22046346
18413839
23948973
26375550
|
E2F2
|
EZH2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
18319725
14532106
|
NRAS
|
ERBB3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
12.0
|
1.0
|
Reactome
|
23220880
25853726
30301790
28274957
18039657
16843263
25994018
26545934
22046346
18413839
23948973
26375550
|
ERBB3
|
PIK3R3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
16273093
17496910
24189400
|
ERBB3
|
PIK3R2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
17496910
16273093
24189400
16729043
|
PDGFA
|
PDGFRA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
24.0
|
1.0
|
Omnipath
|
23331499
9739761
25241761
7679113
15767546
21071413
15207811
2544881
11297552
152078112544881
11803579
15207812
28267575
|
PIK3R2
|
NRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
31135801
24897931
8665852
17998941
11136978
21779505
8052307
12121613
1716764
26085527
21779497
12094235
|
NRAS
|
ZDHHC9
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
29311131
21779505
2661017
16000296
|
PRKCB
|
MARCKS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
41.0
|
1.0
|
Omnipath
|
17081983
20166139
18767875
17322306
11162562
19413330
19664995
18578522
91317794
20068231
11930178
16116087
18669648
8557118
17287340
8422248
19651622
20058876
18707149
7588787
18212344
|
PRKCB
|
MET
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
14.0
|
1.0
|
Omnipath
|
17496910
11940581
21386996
11447289
19615955
16488589
6321473
8321321
12845332
11313945
12040186
19568798
15567848
14585353
|
PRKCG
|
MET
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
14.0
|
1.0
|
Omnipath
|
17496910
11940581
21386996
11447289
19615955
16488589
6321473
8321321
12845332
11313945
12040186
19568798
15567848
14585353
|