Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
MDM2 ATM â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 19816404 21986495
SP1 ATM â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15837784 11466608
BCL2L1 BAK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
BAK1 GRN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
BCL2L1 BAK1 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
BAX CASP12 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12209154
VDAC1 BCL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0907555106 19706527
PPP3R1 BCL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217580 15757646
DDIT3 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15836916 20398749
PAX8 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9413150 11453662
BCL2 PPP3R1 â—¼   COLOCALIZATION 2.0 0.8 intact 5217580 15757646
DDIT3 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17652152
FLI1 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11847117
BCL6 CCNA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11920165 11341761
TP53 BCL6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16249378
BCL6 ZBTB17 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17828269
BCL6 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15577913
CDKN1A DDB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19541625 0812254106
NUPR1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22858377 18690848
CDKN1A TP53 â—¼   COLOCALIZATION 2.0 0.8 intact 16616141 5218511
CCNA1 CDKN1A â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
DDB2 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16678110
TGFB1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23741479 12058028
CDKN1B CCND2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
TCF3 CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19451188 20191379
CCNA1 CDKN1B â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
RELA CTSB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18598236 15102937
TP53 DDB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11971958
DDIT3 CCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18649942 15829559
TP53 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
CEBPA ICAM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9916895
TNF ICAM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21474822 22846676
IRF9 IRF7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10924517 12768031
IRF7 IFNA7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10938111 19349300
FLI1 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15592502 20153576
MDM2 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21988832 23839035
RELA MICA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15494508
PRKCD CYBA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19948736
TNF CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21887257 19287455
TP53 JUN â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11350971 10984493
TP53 CDKN2C â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
PAX8 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 8521821
TP53 ANTXR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11711532
TP53 MFN2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22510407 20804729
MYCN TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20145147
TP53 CASP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
TP53 BIRC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16917513
TP53 ID2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16557594
FLI1 CCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 25108845 23108091
GPSM3 GRN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TCF3 ID2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19321746 0900912106
MYCN ID2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12670915
CFB C3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 809512 279011
CFD C3 â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 809512 279011
TAB3 RBCK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16260783 16953224
TAB1 RBCK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16260783 16953224
TIMP3 MMP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11827795 16189514
NFKBIB CCL5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15609310 24383830
SP1 CCL5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19124744
FSTL1 TGFB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20860622 7990613
TFE3 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20713358 21389977
RELA ZEB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23584475 16862183
HDAC2 BCL11B â—¼   COLOCALIZATION 2.0 0.8 intact 5219549 17245431
RELA JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17310108 10646503
JUN CASP8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18196534 17922191
MEF2C JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 9384584
CASP1 NLRP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0802726105 18511561
BIRC2 CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17145710 12887920
CASP8 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11002417
NFKBIB CHUK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
RELA NFKBIZ â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20220144
SPI1 CD14 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18227805 12393465
CEBPA CD14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15676205
SP1 IL2RB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9199305
SPI1 CEBPA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8695841 22474248
SPI1 CSF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15676205
SPI1 CSF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8264604
CEBPB CSF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7513199 21455770
TAB1 CARD9 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22069318 20038579
CD4 HLA-DQA2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
TAB3 CARD9 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22069318 20038579
SP1 CEBPA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10373535 12049196
TRAF3 BIRC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18997792 18997794
BIRC3 BIRC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23070005 18485876
TNFAIP3 TICAM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217223 15474016
HLA-DQA2 LGMN â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 8134367 18292509
TRAF3 CD40 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7527023 5220338
CUX1 CD40 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12374738 18085478
TFE3 CD40 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14962802 11818452
TRAF3 BIRC3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18997792 18997794
NFKBIZ DEFB4A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18362142 17447895
CEBPB DEFB4A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15985221 11781391
CEBPA CSF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15676205
ATF1 CCNA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10683356 7843287
CFB CFH â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 1067618 301546
ZBTB17 LDLR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14704274 11545736
CNPY3 GRN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ATF1 CCNA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12044952
ATF1 ARNT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12527906
EWSR1 FLI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16206264 10975680
FLI1 EWSR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16206264 10975680
CFD CFB â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 809512 279011
KLF3 GRN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
GRN VDAC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
GRN H3-5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
EWSR1 ATF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9569031 12527906
CEBPE CAMP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11313242 12515729
CFI C4A â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 293746 702059
ATM RBBP8 â—¼   PHOSPHORYLATION ✅ - 0.8 0.8 Signor 10910365
TICAM1 TRAF3 â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
MBL2 UBQLN2 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HuRI 32296183
EGFR DDX5 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31980649 28065597
PRCC EGFR â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 20029029 31980649
C3 CFD â—¼   PHYSICAL_INTERACTION 819.0 0.82 STRING 36370105
TGFB1 LAMB1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 27684187 20936779
MYCN HDAC2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31856871 20697349
CARD8 TAB1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 26186194
C1R BIRC2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
AFF1 CCNT1 â—¼   PHYSICAL_INTERACTION 819.0 0.82 STRING 36370105
CASP5 CASP4 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
CDK9 DDX5 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 17643375 26209609
CDK9 GRN â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 32814053 12588988
C1R C1QA â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 2372546 10878362
TRAF3 BIRC2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 20097753 30561431 33608556 23524849
CCNA2 CCNA1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
CNPY3 PXDN â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
VDAC1 VDAC2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 31536960 22939629 29128334
CHUK NFKBIB â—¼   PHYSICAL_INTERACTION 830.0 0.83 STRING 36370105
CDK9 TP53 â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
SRPK1 DDX5 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 32707033 25852190
C1QC C1QB â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 21054788 16189514 12960167 28325905
CEBPB SP1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 16651265 12847250 12665574
TRAF3 BIRC3 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 20097753 33608556 23524849 23612708
BAK1 TP53 â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
CDK9 CCNT2 â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 24981860
SPI1 JUN â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 12091339 9681824
MYCN SP1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 18003922 21123453 20697349
JUN SP1 â—¼   PHYSICAL_INTERACTION 856.0 0.85 STRING 36370105
CHUK RELA â—¼   PHOSPHORYLATION ✅ + 0.85 0.85 Signor 10521409
CASP8 BCL2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16183855 11406564
FSTL1 CD14 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 20860622 22265692
SPI1 CEBPA â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16983342 12091339
BIRC2 CASP8 â—¼   PHYSICAL_INTERACTION 861.0 0.86 STRING 36370105
TAB1 TAB3 â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
IKBKE TNF â—¼   PHYSICAL_INTERACTION 866.0 0.86 STRING 36370105
BAX VDAC1 â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
CEBPE DDIT3 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 15588942 23661758 20211142
CASP8 BIRC2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 12887920 27810922 15069192 22274400
BCL2 BCL2L1 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
CDK9 MLLT3 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
CFH CFI â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
AFF1 MLLT3 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
CDKN1A MDM2 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
AFF1 CDK9 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
HDAC2 TP53 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
BIRC2 TNF â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
RELA SP1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
MASP1 MBL2 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
CHUK RELA â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
IKBKE TRAF3 â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
IRAK4 IRAK2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 20485341 21903422
HDAC2 SP1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 17312152 18059533 16713569 15713621 17894944 12091390 16036112 12151407 21159880 12176973 20697349
CEBPB CEBPA â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 20102225 1840554 15751966
TNF TNFAIP3 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
RBCK1 TNF â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
HDAC2 RELA â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
BCL2 TP53 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
CCND2 CDKN1B â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
DEFA1 UBQLN2 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HuRI 32296183
VDAC1 BAX â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 9843949 16189514 15637055 28760928 12767928
AFF1 CDK9 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 32707033 32479599 20153263 33961781 21729782 21030982 23602568 26186194 27684187 23455922 24367103
CEBPA DDIT3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 33961781 27555288 23661758 20102225
JUN DDIT3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10523647 23661758
EGFR TAB1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 31980649 24658140 25402006 18271526
C1QB C1QA â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 14681455 21054788 12960167
SP1 JUN â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 25879517 10506225 16713569 33572115 16478997 17215518
TAB3 TAB1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 14670075 18021073 27880917 33961781 21903422
AFF1 CCNT1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 20153263 21030982 27684187 19956800 24367103
CCNT1 GRN â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 12588988 16713569
HDAC2 SP1 â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
NFKBIB RELA â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
CCNA1 CDKN1B â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
TP53 ATM â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 9843217 9733515 9733514
ATM ATF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20730097
TP53 BAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16713569 15077116
ZBTB17 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21167753 19549844 17082179
CEBPB BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12970736 19717648 17043638
JUN BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14623928 17262823 19335069
ATF1 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10542244
CEBPB BCL2A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19489038 18512730 12665576
CEBPB BCL2L1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19043455
SIN3A BCL6 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16147992 9765306 9753732
TP53 BCL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23852341 19427386
CDKN1A CTSB â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
EWSR1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12560328 18757425 20153576
JUN CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10700231 20566634 19959471
CEBPB DDIT3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12706815 20562859 33961781 20102225 1547942 8662954
JUN DDIT3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19299913 22622069 12069855
MYCN EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16093321
RELA EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17881446 23379415
TNFAIP3 IKBKE â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18353649 15661910
IRF7 IRAK4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15361868 15767370 15492225
TP53 CCNA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17530187 15456866
TP53 CCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22804246 23666675 20406462
TP53 CDKN2C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16169070 16713569
SP1 CXCL1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11115149 7479086 11112786
C1R C1QA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10904115 15388251 761607
C1QC C1QA â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 14681455 21054788 12960167 28325905
C1QA C2 â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 6019133 12396008 10925294
C1QA C4A â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 15199963 14280442 12396008
MASP1 MBL2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11290788 32041782 20956340 27104295 10878362 21035894 19939495 22854970 18177377 25579818
C4A MBL2 â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 15199963 14280442 12396008
C2 MBL2 â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 6019133 12396008 10925294
C3 CFI â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 6607952 21788512 2971659
C1R C1QC â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10904115 15388251 761607
C1QC C1S â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10904115 15388251 761607
C1QC C2 â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 6019133 12396008 10925294
C1QC C4A â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 15199963 14280442 12396008
C1R C1QB â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10904115 15388251 761607
C1QB C1S â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10904115 15388251 761607
C1QB C4A â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 15199963 14280442 12396008
C1QB C2 â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 6019133 12396008 10925294
IRAK4 MYD88 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 32296183 16189514 25416956 24735611 17548806 12860405 25910212 18221795 24316379 25502805 20485341 22011580 11960013 26871637 12538665
IRAK2 MYD88 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9374458 20485341 22011580 10383454 12659850
CXCL8 MMP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18660381 17375198 11023497
SPI1 CCL5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10760799 16707500
JUN GZMB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath
JUN NTRK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15870692
JUN TIMP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9182717 23078099 18289921
GZMB CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19103589 15569669 17283187
RELA TNFAIP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11880364 19343319 10807933
CD14 TRAF3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16306937 19898473 16306936
CEBPE SPI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12032776 12202480
SP1 CSF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7811231 8524292 11418664
IRAK2 TAB1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15327770 19675569 10882101
IRAK2 TAB3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15327770 19675569 10882101
SP1 NTRK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19656944 19643914 21123453
TNFAIP3 TICAM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15474016
TRAF3 TICAM1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16306937 19898473 16306936
CUX1 NTRK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 23951412 16275928 10900073
C1S C1R â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 31749804 10092586 2387866 9477945 33961781 10878362 2372546 12788922 17996945
C1S C4A â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 15199963 14280442 12396008
C1R C2 â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 6019133 12396008 10925294
C1R C4A â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 15199963 14280442 12396008
CFH CFI â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 26806831 9291131 1401896
C2 MASP1 â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 6019133 12396008 10925294
C4A MASP1 â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 15199963 14280442 12396008
MASP1 C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11907111 10946292 11527969
CASP4 CASP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12843244 9491891 9039262
C1QB C1QC â—¼   PHYSICAL_INTERACTION 907.0 0.9 STRING 36370105
LAMA5 LAMB1 â—¼   PHYSICAL_INTERACTION 907.0 0.9 STRING 36370105
CCND2 CDKN1A â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
BAX BCL2L1 â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
KRT20 KRT27 â—¼   PHYSICAL_INTERACTION 0.91 0.91 HuRI 32296183
ATM TP53 â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
C1QB UBQLN2 â—¼   PHYSICAL_INTERACTION 0.91 0.91 HuRI 32296183
CCNA2 CDKN1A â—¼   PHYSICAL_INTERACTION 921.0 0.92 STRING 36370105
DEFA6 UBQLN2 â—¼   PHYSICAL_INTERACTION 0.92 0.92 HuRI 32296183
C1QA UBQLN2 â—¼   PHYSICAL_INTERACTION 0.92 0.92 HuRI 32296183
CCNA1 CDKN1A â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
BAK1 BCL2A1 â—¼   PHYSICAL_INTERACTION 928.0 0.92 STRING 36370105
ICAM1 UBQLN2 â—¼   PHYSICAL_INTERACTION 0.93 0.93 HuRI 32296183
C1QC UBQLN2 â—¼   PHYSICAL_INTERACTION 0.93 0.93 HuRI 32296183
MYD88 IRF7 â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 15361868 16484229
SP1 TP53 â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
IRAK2 IRAK4 â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
CDKN1A CCND2 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 16765349 5218735
PPP3CC PPP3R1 â—¼   PHYSICAL_INTERACTION 952.0 0.95 STRING 36370105
ID2 TCF3 â—¼   PHYSICAL_INTERACTION 955.0 0.95 STRING 36370105
CDKN1B CCNA2 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 34591612
C1QA C1QC â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
ATG12 ATG16L1 â—¼   PHYSICAL_INTERACTION 962.0 0.96 STRING 36370105
C1QA C1QB â—¼   PHYSICAL_INTERACTION 967.0 0.96 STRING 36370105
CDKN1A TP53 â—¼   PHYSICAL_INTERACTION 968.0 0.96 STRING 36370105
CDK9 CCNT1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 9499409 11145967 15328539 17643375 20562857 9491887 20305087 15713662 19387490 11713532 27684187 14627702 23455922 16980611 26659056 15107825 12588988 12944466 14580347 20153263 22959624 16109377 12115727 21729782 23602568 11282025 30649429 19914168 18483487 24367103 20535204 12832472 19818711 12894230 9872325 23064645 30652970 15713661 21697490 22483617 22939629 32707033 11713533 15528190 15546612 10958691 10617616 10574912 18566585 10465067 24981860 33961781 11689688 17700062 26186194 26344197
CDK9 CCNT2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 32707033 9499409 16331689 18566585 17643375 10465067 33961781 24981860 21729782 26186194 23602568 11282025 27684187 23455922 11713533 26344197
SIN3A HDAC2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 16254079 12398767 21258344 12943729 9885572 9150134 12453419 12493763 14749338 22493095 12082111 25314079 12091390 17827154 12724404 23752268 18059533 9804427 26949739 24981860 15451426 26344197
ATG5 ATG12 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 11825910 12890687 12482611 17353931 20562859 23202584 31612776 22342342 33961781 28253979 33024031 32129924
ICAM1 ITGAL â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
C1R C1S â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
C3 CFI â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
IRAK2 MYD88 â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
C3 CFB â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
BCL2L1 TP53 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
CDK9 CCNT1 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 6613869 18483487
BAX BCL2 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
BAK1 BCL2L1 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
C3 CFH â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
CD40 TRAF3 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
CCNA2 CDKN1B â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
BAX BCL2 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 21778226 18981409 15899854 32064756 10620799 21199865 17289999 9194558 8358790 21671007 16642033 21458670 22262057 9388232 10716992 20865015 14980220 9111042 24141421 17097560 15231068 9463381 33961781 17525735 29749471 23479509 26004684
TP53 MDM2 â—¼   PHYSICAL_INTERACTION ✅ 0.99 0.99 mint 17139261 5219401
IRAK4 MYD88 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
CCNT2 CDK9 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
ATG16L1 ATG5 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
ATG12 ATG5 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
MDM2 TP53 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ATM MDM2 â—¼   ENZYMATIC_REACTION ✅ 54.0 1.0 ACSN 11331603 11438669 11804596 11877377 12086603 12556884 12607003 14988723 15136767 15140942 15175241 15459660 15485915 15798197 15867354 15964794 16163361 16332722 16581787 16713580 16731533 16805667 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17713585 18006705 18048416 18469862 18511906 18583988 18716619 18756267 18995830 19151707 19282663 19342888 19357644 19490890 19622404 19788416 19793801 19793861 19841479 20019063 20051983 21376743 23847781 9168117 9858600
ATM SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 23148884 18619531 22826432 27156884 29144413 29294106 23046908 17609267 18171990
ATM TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 452.0 1.0 Omnipath 25301947 21720806 23549171 10713094 16501611 15077171 24886358 17570479 19375142 22028490 16916644 14712210 19303885 9407038 11927276 26700820 28356518 15226429 10723129 19788889 12064478 19705844 26673821 22179422 20931131 19062161 27030982 22891162 17157788 19056039 15758953 12049739 15361830 26620371 25865756 22615843 10196661 10656682 11313957 25088203 15140942 12519769 16319535 24469230 12776195 17234789 27511909 29238697 24608431 12927814 16783362 11875057 16436515 22778557 15181149 12702572 10500142 15178764 28842590 28145533 11591448 17855337 22726545 20206688 26824362 21317290 26104798 24704793 9765199 11314044 16906133 17174997 21593792 17967874 10771484 15585169 19625493 15178448 17596534 16288207 15048074 18353733 24057508 19535302 29344296 23708100 29872395 23705030 25043304 33761896 18431490 21404020 15024084 22559321 12151394 24078877 12080066 33982778 16893723 10958792 18289945 27183917 26337656 29170437 18765533 10744722 21748595 18056442 24820418 15489892 16390936 24086335 28140789 23091651 34523970 32001619 23418564 15279808 21317932 21188172 27559048 16818505 17616578 11551930 19010925 11709713 24711418 28654064 18339864 11173129 17486112 10570149 29774100 18381438 21994612 29558908 15258567 9372954 25860929 16858402 33692124 15775976 34107253 19923893 24958101 10436023 14752509 19962312 19071090 26438152 26093282 20123963 22444248 9843217 17525332 15456784 23533526 11780126 20353948 29290977 11096068 28102346 18855897 20372057 24395704 23890999 15725625 15806145 34103468 18345031 16997395 16293623 28477117 19828454 27630139 12071847 22002314 21315088 27177180 12645530 12890678 26113041 15794754 18560558 22099307 9885574 28903382 15665826 24877058 18332866 10611322 24380814 14871840 19934315 22975381 16489034 18406507 21440540 33687951 10608806 23892398 20730097 16914171 15782130 15177184 22055193 18490454 25867001 24349352 18045533 20663147 17535811 20506250 23982736 22375140 15700044 15279774 19266268 24358288 18697815 14729946 20637859 12242661 12771937 17371838 31940492 19409520 10528155 24037342 17257427 11121242 15310764 23148227 28915641 26928575 21423215 11865061 16949371 27810895 18449195 20711232 27389279 22213803 16713569 10446957 22797063 16478990 29048667 15489221 17241873 21187893 21441950 23907539 20005840 9733514 26244501 21614094 12082529 10467728 10714958 32061892 16636671 29147215 10673501 12091386 25202122 21465263 19544417 25823026 24078903 24038750 22198295 21480565 15177039 28182994 28208785 18674635 20183804 18818083 9925639 17712528 15254178 11483158 27940348 26675349 26261212 19717643 12606585 24559687 14871926 23150668 21329876 28153791 12518062 12767922 23824039 11711532 19251701 28118604 15078887 12393500 17456577 20976220 23380594 12519780 20810927 15533933 22420423 17108107 20145032 18032786 18785202 22037398 23184057 31968249 16729035 12588868 21614932 11546806 18614045 14757188 15029243 14968111 22649771 25512053 34496248 18604166 17609585 17976513 16223874 25433195 18985806 9363941 15159397 34282274 29301278 24505404 26056062 23577291 18272544 18715874 19536869 29334356 10801407 15155458 25201202 24376853 19907922 23525106 14643431 28340339 28051100 19085961 15212693 22201816 20026654 16322229 20080565 9733515 15632067 18672098 22577550 25691451 12637545 12548019 11672523 26984736 12324477 16552184 22084686 10864201 14744854 21532626 17118344 19482562 9561848 12511424 17668048 23358251 18511169 21460853 22022355 12939400 21415014 17292432 25651062 23168260 12111733 16648554 30361254 23678107
ATM MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 66.0 1.0 Omnipath 14654783 12383858 17936559 20651945 17303408 19816404 10611322 23150762 23277204 23386996 26416444 27258263 23002429 11331603 15865937 21556066 16163361 23708100 17570479 20514355 22264782 27177180 18265945 28690977 23847781 22264786 15140942 15964794 19788416 22624716 25201202 27462439 12607003 28050229 32350255 22649771 27956626 15459660 22976441 25247188 28904407 11877377 21859827 24534650 23405218 29290977 27568562
ATM RBBP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 26.0 1.0 Omnipath 23468639 23675572 17570479 24837676 10910365 16249056 11689934 10608806 17525332 22743550
BCL2 BAK1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 ACSN 11704864 17446862 22039431 23064052 23377657 23430059 23850759 8929532
BAK1 VDAC2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 ACSN 12881569 19706873 22039431 23430059 23850759
BCL2 BAK1 â—¼   PROTEIN_INTERACTION 8.0 1.0 ACSN 11704864 17446862 22039431 23064052 23377657 23430059 23850759 8929532
BAK1 VDAC2 â—¼   PROTEIN_INTERACTION 5.0 1.0 ACSN 12881569 19706873 22039431 23430059 23850759
DDIT3 BAK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17166886 23339468 16597647 14612528
TP53 BAK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 22983126 18519674 21233848 15033822 15489892 15105295 10741712
BCL2 BAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 17145710 9463381 14980220 11206074 17289999 26004684 11728179 20836993 19168699
BCL2L1 BAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 35.0 1.0 Omnipath 22705850 9463381 22516262 31467278 32814053 9020082 23680104 34098062 18178565 15901672 16189514 17446862 20836993 23055042 19060904 17289999 32296183 10085290 14596824 15292519 29997244 31515488 11175750 9027312
VDAC2 BAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 22705850 17353931 12881569 16189514
BAK1 VDAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9843949 10365962 10639121
BAK1 BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15901672 11571294 16189514 16439990
BCL2 BAX â—¼   PHYSICAL_INTERACTION 15.0 1.0 ACSN 11704864 16227588 17446862 17891140 20709625 21641962 22039431 23064052 23377657 23430059 23850759 7644501 8358790 8929532 9872359
BCL2 BAX â—¼   PROTEIN_INTERACTION 15.0 1.0 ACSN 11704864 16227588 17446862 17891140 20709625 21641962 22039431 23064052 23377657 23430059 23850759 7644501 8358790 8929532 9872359
TP53 BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 74.0 1.0 Omnipath 11278953 12203124 16931621 9582019 17693666 11118038 12433990 11395510 8183578 11429705 10400708 15242522 11423991 19067706 24336083 18381427 22732402 15988033 16341121 10935506 10094833 16215989 17280505 10744634 12851404 20673369 15851483 8845569 10559267 12168779 11850816 19505426 8564971 11756653 19054058 15566940 12173040 17690113 8635454 18034190 10510469 10101800 11335718 23100276 9400998 9445173 9582400 24098340 22532570 9122197 11420692 11104574 15679092 11748232 12560513 11928223 20400479 20546728 17145718 20567883 20840522 18172861 10566557 10777477 7834749 12806965 17521288 19242108 9000137 21859835
SP1 BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11278953 10510469 11748232
RELA BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18034190 18158998 20056115
BCL2L1 BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 59.0 1.0 Omnipath 22705850 18981409 21458670 28202514 11283018 17525735 29749471 21567405 9388232 18547146 19074440 16151013 21199865 18178565 26496610 16189514 15486085 26186194 17289999 9111042 12419244 25241761 14963330 12853473 9742125 9153240 19427863 21852238 14766748 21671007 15131699 9670005 8596636 24814347 9824152 9027312
BCL2 BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 60.0 1.0 Omnipath 17145710 22705850 18981409 9463381 21458670 17097560 17525735 8358790 10620799 26004684 29749471 9388232 21199865 17525161 22262057 21778226 15486085 17289999 9111042 12419244 9194558 15231068 10716992 8183370 14980220 9115213 21671007 16642033 23479509 10677502
TP53 BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14963330 16151013 7834749
BAX VDAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 16189514 10365962 9843949 12767928
CEBPA BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16254192 18987666 23814099 15713621 12970736
SP1 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 14660675 20435036 12032828 10542244 15713621
RELA BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 17673602 18031796 12835724 15120608 20332461 14978135 20446017 18566231 19259124 14739605 21503108 20103608 17098279 18158998 19233129 16022909 18761399 18191642 21224428 16453001
TP53 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 41.0 1.0 Omnipath 17693666 8183578 10037739 16738310 18397889 19521340 18487508 21666495 16294215 21656028 22869582 19714248 10744634 8174112 17592775 11782367 19137013 20428827 18682598 11713302 11313951 20501806 9649502 24814047 15767042 24098340 11193470 10329733 21859835 22266868 10953306 19555669 23638218 14684736 19411072 20530667 24155778 8205530 20840522 9000137 15326476
TP53 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 12667443 19555669 8205530 19007744 11313951
BCL2L1 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18835031 14980220 26186194 11583631
BCL2 NLRP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17418785 19223583
BCL2 CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 16183855 11406564
RELA BCL2A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10049356 19343319 17000776 11880364 15592513 10733571
RELA BCL2L1 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 15079071 15536066 17550372 19171876 23430059 8383323 9743347
RELA BCL2L1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 10925251 17673602 14978135 20585448 15231833 14739605 10585435 20066113 16904634 9439816 10733571 15756023 15986355 21722408 12226754 15856023 16453001 18223231 19706766
TP53 BCL2L1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 22869582 9582400 9989972 11713584 18172861 23519249 12705879 9000137 11713302
TP53 BCL2L1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 24814347 12667443 16151013 26556313 14963330 16713569 20837658 24474649 21900206
BCL2L1 VDAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 12767928 17209561 16189514 10365962 10737788
BCL2L1 NLRP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17418785 19223583
BCL2L1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 24814347 12667443 16151013 26556313 14963330 16713569 20837658 24474649 21900206
SPI1 BCL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 19564417 15892171 31000603
BCL6 CCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23954399 12097386 21801248 21106671 10973278
BCL6 CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 19337254 18648506 15509806 22723377 17392284
CCNT1 CDK9 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
CDK9 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 24173284 9372954 11483158 9315650 19413330 19664995 23603988 24202322 11709713 16083285 1088347 16552184 10884347 24286312 10747897 17942552 16741955 17287340 92065884 12064478 10348343 14702041
CEBPA CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15466360 9442037 12502863 8846917
ID2 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17639499 16557594 21900881 16428453 11706002
TP53 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 389.0 1.0 Omnipath 9349504 22270849 8749722 21242964 22290440 23874636 23349794 23650552 17280505 16288208 19882681 22948151 8641969 18840648 7777546 9360984 9707425 14614448 15586362 12889596 10597242 18719376 17938176 16343438 9916993 12806965 15024021 10037739 19394332 19749793 22480684 15136035 19501055 22732402 15988033 17307334 18272192 23665236 20331637 10435630 12239594 14743206 24599959 9714336 9652736 19954840 12392301 15339933 9154806 19383287 21295542 16894028 23187802 15248906 14522900 18483411 16261158 11892838 20190809 17167174 18615633 15790310 17916908 19472317 12717415 19789303 16317118 7696178 24584189 22989750 18573881 22532570 9288775 16103882 11890931 17646389 17344317 10753197 8557703 15872011 24356969 11278953 22279545 12902982 9920903 18644983 21524151 16540664 10935506 16537920 19843844 9535786 17878219 9405685 10749849 18656471 11021966 19723072 16778363 18628250 16557594 9614553 21791610 10072388 12203124 12420214 12640112 16601686 20531308 15741235 17317670 18446786 18505818 9224526 17569660 21900401 14517211 12934105 22713239 11313928 15492238 17509529 15985438 14722112 18755897 15489892 23759594 7624148 17786325 9223430 24074410 9525742 11395510 21317932 11444825 18645021 15856024 10559267 18593586 16970927 12665570 10101800 23017582 20696891 9268733 22001409 24821728 23146670 22427654 12573582 19118657 11973611 24096481 20797428 17685229 23066038 10029406 12681065 12433990 18769160 15208672 11152513 8547219 15851483 23474493 24384472 11175333 17158927 23100276 17762884 18951877 12045203 15051477 16107883 18521083 23159636 8603071 20814747 15082782 11375890 21084835 10348346 22244155 21325288 12379483 14580351 17592775 8910340 15566940 12173040 12007564 12609999 8878553 12080472 12384701 22266868 17404570 23329847 7478511 15067082 15007388 16458891 9268365 15728246 17224908 10094833 15897882 18059034 11739748 7624134 17146435 18690848 21528307 21546904 18208621 18172861 17977830 17721438 20817677 22894933 18225552 21642427 11162600 9183012 8647846 10660101 21858218 22514644 18451802 11384995 20673369 7774811 20187950 16230382 17339230 12168779 19630958 8242752 9895308 21606339 11748232 16410722 22611192 16061648 15009091 22503977 8799837 15660129 20473858 20448457 16488074 14612423 21903579 11668476 11313463 17101782 19067706 17121856 10792001 16341121 12925527 7566157 22190353 12782287 9233781 15509808 21245169 17145718 24134839 10498892 18094076 14635196 23208500 20843368 10327058 21969549 9440695 10625687 20885946 12851404 19846554 10910098 14614455 18419600 21552844 24835508 21541551 9472102 11922774 19244234 17903248 9216067 18193090 10566557 18757425 11429705 19608464 8632901 8691637 15184659 12716906 15259070 24559687 7970699 15738655 9588214 16574813 15302882 12560513 16131836 16778203 10522058 11032828 9816111 9108440 15860260 17108107 25024194 9582019 22266186 20036872 9926942 15710329 19243472 17997002 19435914 21093383 23149933 11162506 17678435 11895854 8616838 12748190 17610896 18269916 22086179 21557991 17942917 24821727 11557753 16204065 18645003 24205274 9816061 12226108 24379401 15539944 7753560 15371422 10799578 10777217 16434701 17996705 21957244 9191059 9519881 9207798 24289924 21733196 15496412 20124454 20153576 22172947 10321740 21715977 22253232 8816885 24189165 15882981 8752276 20511722 11514734 20962589 12869419 16733561 19713748 16931520 10499591 16581545 19738071
RELA CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18954936 22305266 23037503 18269916
CEBPB CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10982390 15466360 15041706
JUN CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11136975 12717415 21278055 10506225 19628677 12054510 18094076 10072388 18210215 10733944
CUX1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11584018 12438259 15812824 15269344
SP1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 101.0 1.0 Omnipath 9580699 15978937 15557281 11064455 16103879 19584258 20301197 20935676 15961274 15361832 11274368 11842244 15489892 15302882 10212208 12796485 23184467 14529564 12806965 9819384 10321829 10649433 12434298 18270969 18850004 16081043 9183012 21858218 10809237 9618481 16298343 11574165 10362258 11384995 15659839 14744793 10030670 17090534 10733944 19318349 12665570 18202149 17516505 15033443 22001409 17885207 10485470 9553133 15345676 15694838 22427654 17556661 10506225 23066038 15979845 18636159 14527674 24821727 15899840 14755691 12151347 24589735 18210215 23877711 11953011 21311948 15528212 15790310 10878024 22132221 12782287 12773551 8995437 21184768 12379120 17026958 24451377 10601254 8557703 16810128 16533812 7499379 10625687 15389873 16706751 12727210 21325288 16818630 18419600 15041706 23235480 19244234 15694666 23329847 18509005
TP53 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 19922265 12897156 19597488 16616141 28433629 20066118 20457558 19749794 6396087 21163364 17371838 21900206 21340684 25241761 12897801 12748190 20182602 11896572
MDM2 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17373842 25241761 20086099 14633995 14761977 20308078
ZBTB17 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 9618481 12545156 17550342 17828269 10454538 15155580 11283613 11283614
SP1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 17026958 9389648 9618481 17550342 12545156 11013220 15155580 11074002
CDKN1A CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 23443559 26186194 25241761 27107012 8756624 15169570 25416956 16765349 31515488 16189514 32296183
CDKN1A CCNA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 12383116 25241761 8756624 29997244 16982699 7478582 10022926 32814053 15232106 16009130 16189514
CDKN1A CCNA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 23443559 26186194 21308745 9660939 8756624 15890360 9380407 8242751 8662825 12947099 9632134 17679094 26496610
TP53 CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15145945 15988033 19235838 10516009 21478095 14984207 19427386
SP1 CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 9349726 12907235 18355800 10072762 19145069 21131823 22415074 15064717 15951157 16105842 23184467 15899840 12773549 12907249 10542271 16518840 11231912 19433067
TP53 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21340684 20066118 20457558 20182602 6396087
CDKN1B CCNA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 15583032 29997244 7478582 10022926 18692475 32814053 16189514
CDKN1B CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 25910212 16189514
CDKN1B CCNA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 17145710 8684460 26186194 9660939 17254966 15890360 16209941 12947099 12501191 26496610 9724724 9311993 9716181
TP53 DDB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12771027 22336944 15856024 12509284 12170778 16357511 12967652 15927209 11971958
CEBPB DDIT3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 8051100 16757577 10085237 8662954
DDIT3 CEBPA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 7588595 21983012 11050169
DDIT3 CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 18772138 22031759 17709599 15688424 21471847 18850010 17197543 15659384
DDX5 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 24219989 15660129 20876186 19626115
JUN EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16170369 23455325 15923621 16423552 10803405 18604200
TP53 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 20190820 18359760 9664135 10029407 8152794 11713584 8887630 9285564 19597475 11546792 1586628 18604200 18391986
SP1 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 1282800 17616668 18575762 19538880 15665278 18202149 20435036 21705183 18007664 21464950 23821666 15533438 9819401 10830317 8393457 16087726 20407012 18391986
TGFB1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20953304 32103204 19132220 28943431
PRKCD EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 11447289 8321321 11313945 12040186 15302935 6321473 1860884 6090944 19568798 14585353 17496910 21386996 2984676 11940581 85012702 19615955 2987962 12845332 3379075 15567848 16488589 17956904
ICAM1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16799092 17145710
RELA ICAM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 55.0 1.0 Omnipath 10926553 7822333 9192770 9831247 7957928 15996193 22337883 19074768 16778171 9188493 16317091 17121934 18928584 15843586 22001597 9056676 18285351 16385502 10946302 15946255 20103608 10738944 15800027 22708120 23238746 22901690 9888295 11877286 7659084 17855547 10553096 10092659 9733827 11401521 11463837 9916895 20173029 10837365 16455661 19351910 20823682 12691701 16105834 12490396 17537731 22345292 10228026 16453001 19278584
JUN ICAM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11356008 12832416 9218873 20459645
ICAM1 ITGAL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 11786177 16595626 16354667 12526797 23602662 11279101 16189514 14507735
CD14 IKBKE â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 12692549 15210742 14530355 17526488 17047224 14703513 19656901 17823124 23453971
TRAF3 IKBKE â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 12692549 15210742 16306936 16281057 14530355 17526488 17047224 14703513 23453971
IKBKE TICAM1 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 12692549 15210742 16306936 16281057 14530355 17526488 17047224 14703513 23453971
TICAM1 IKBKE â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 14739303 16410796 12692549 16281057
TRAF3 IKBKE â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 16177806 15210742 15210743 16306936 16127453 17468758 12702806 17327220 16858409 24763515
IKBKE IRF7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 16625202 25225665 9786932 15210742 22787218 10893229 26712804 16127453 12702806 16380379 15367631 12692549 17706453 16199137 16914100
IKBKE RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 28317833 12842894 16046471 20188669 15128824 17561400 17003035 30223576 15485852 10521409 15489227 15849198 16407239 26025205 15212693 12767944
CD14 IRF7 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 14517278 15210742 14703513 9566918 17823124 17157040
TRAF3 IRF7 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15210742 16281057 14703513 9566918 17157040
TICAM1 IRF7 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15210742 16281057 14703513 9566918 17157040
RELA IRF7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15265881 16982926 11877397
TP53 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 201.0 1.0 Omnipath 23150757 20948295 10871862 10914734 21422812 21957016 14532965 22290440 20663877 20547751 11591713 24339722 11840331 22223137 16492744 15843377 22948151 7888679 20156675 21217645 22180176 8319905 9707425 15831521 17690113 9649502 10688649 9194564 15917661 15090541 20837136 8187772 10788589 17907153 15192123 8440237 11964305 16510138 10856296 15580300 7624148 12208736 21211512 16624812 17848574 11245471 21637567 20588255 10562557 9525742 9270029 16479015 19941079 14602726 15024021 18814047 20036872 10718212 18852133 12374749 18397889 25016801 12755686 22081073 22245141 23365201 8957072 22197810 15856024 20703075 23483203 9645455 19648117 20331637 22301280 14743206 23982177 9486848 15734740 19638633 19671680 17310983 10469568 20659896 10072445 21097889 17237821 11748232 11085543 21750655 16337599 21295542 1614537 9815889 9070662 16585169 9472631 17936559 17139261 11328884 12887889 20858413 9858609 14610316 20080970 19505873 11313463 15684615 18359851 18783169 16202543 9267820 12235242 14990790 15851483 7587074 18336191 21478269 17043642 15361831 18025460 23612020 10208414 11756653 24389645 9071998 9430645 9400998 9371494 23149414 22532570 9271120 10777217 22383580 18781178 12606552 14514686 17318220 11127813 16571800 19085961 9207798 10891494 10065155 11593391 14570892 12902982 19649205 20124454 17390010 19955655 12138177 19663772 23581014 15908423 10321740 23150759 19837670 10348346 18632610 9294611 11956627 12750288 12851404 8313378 9135153 15735665 7958853 8247544 9535786 16501602 18566224 8910340 11046142 9405685 7936649 12173040 17329361 21451571 14704432 23874713 18333294 19541936 22787160 18585004 22085928 12080472 7651818 11179471 10949923 19428175 15592502 8413278 11714701 10566557 18583933 9681831 15550242 15007388 19590512
MYCN MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15917661 15644444 15927364 19649205
MDM2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 559.0 1.0 Omnipath 20657550 30005830 17616658 9529249 10321734 33650658 9724739 24462112 24621507 15933712 23826318 24667498 22948151 22653443 23776060 25313037 25241761 19303885 16857591 23246961 19033382 20591651 21149449 25417702 15122315 16579792 27543608 29670376 12208736 17848574 26673821 25277184 23443559 23318437 21060154 15210108 19805293 8875929 8058315 21471462 17879958 25362358 23169665 22301280 21584881 20124408 10980696 26876197 17310983 17380154 15058298 24567357 18665269 30109812 25637791 18467333 22337874 22227409 22389628 15242646 22510990 15950904 15001357 19483087 26540344 14559824 21986495 26556313 20708156 19901969 33765973 32528731 11562347 10202144 22374672 10722742 22083959 21965653 17098746 19234109 30679555 16107876 12690203 22525275 19071110 28542145 12620407 20837658 27129163 9131587 24240685 27031960 10681559 19305137 11744695 19188367 16023600 24659749 17347673 12944468 20395212 22084066 20639885 21454483 12897156 16432196 10347217 10706102 11178989 20174603 16751805 15542844 12842086 11431470 11384992 25739118 15064742 23402884 27462439 16905769 22124327 27215386 12867035 22588298 27336364 14702041 16152627 23776465 22262183 21132010 19411846 18309296 23483203 11709713 18981217 14612427 22920093 23671280 24980433 27905468 25168242 21750659 26238070 22737255 23609977 27282385 20847049 20705607 21075307 28082682 17297477 11697899 17936559 24361594 19098711 15469934 34591612 24998844 16212962 11094089 12915590 17116689 11713288 15144954 23201157 10608892 17591690 25156994 17301054 22444248 26883110 26001071 19160491 22157679 24413661 19357310 23802716 15280377 21317885 11597128 19579266 25624478 18061646 21088494 9223638 10435614 31177307 11331603 22391559 20570896 19941302 9278461 18485870 15604276 18566590 12612087 11046142 14704432 26186194 10935507 16173922 14596917 17159902 25543083 19656744 15848166 18316739 22266868 17056014 19255450 21561866 19590512 11839577 22991965 22266850 24200963 11285227 11713287 22975381 19081178 20660730 26475964 16678796 23261415 20173098 17666403 25464845 32427887 23252402 17438265 20959462 22659184 17470788 22912717 17080083 15247280 19332559 17989425 16870621 18813780 20235143 11278372 10562557 25609649 10561590 19411066 17908790 19568783 7926727 21925390 21988832 24127580 18604177 14499615 17371838 17525743 33061576 21887275 26578655 21084564 16861890 20694676 12552135 22914926 17363365 24643130 1614537 22916255 12381304 34992144 12167711 19857530 15053879 10889512 11486026 22103682 16713569 17110336 17426254 10640350 21316347 21478269 15154850 12529318 16595680 16414131 19597489 23880345 27893708 7686617 27811966 17318220 29997244 27308622 19166840 35044719 16159876 24314634 15313915 25283148 22032989 24926618 18172499 19837670 16215989 23134341 26908445 9824166 18451149 21170087 23572512 21465263 22807444 15013777 16845383 10488081 23946421 11714701 25384516 22474335 25312347 23370271 23150757 18541670 22318540 11925449 21572037 24488098 32066565 17268548 20542919 11572869 16338390 21857681 23150668 19223463 20234175 20484049 11070080 20591429 22575647 11351297 16624812 22411991 20588255 17369817 11223036 15908921 9582019 25103245 17302414 21071676 9450543 31968249 34562520 18332869 14671306 21084285 27856536 30464405 26882543 21726810 33020477 21261729 21268072 12426395 16964247 20659896 19106616 22331460 23728348 10827196 22524527 21098709 9363941 17139261 20080206 14517261 22487680 31652301 17290220 27106262 16866370 24207125 28223335 9271120 15550400 7689721 26350565 10196247 27807478 10766163 15558054 35371302 26203195 29487367 25512388 25954860 18223694 15824742 24842904 14741215 16055726 22085928 32894144 18234963 17875722 18815136 15295102 15308643 15358376 22819825 15094782
IL2RB MICA â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10820393 12811837 14607946 16212621 16815076 17398124 17459805 19833085 19913445 20007590 20856220 21307131 21840487 23124025 24829413 25582338 7512720 7521688 7523571
PRKCD TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17906639 16314418 16377624
PRKCD C5AR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 17145764 12464600 10636859
PRKCD FLI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 26055516 22591006 19158279 25707716 22829238 21321929 24708674 24058639
PRKCD CARD9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 29352133 22265677 27926862
TNF TRAF3 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 7639698 25152365 19815541 8702708 7544915
TNF TAB3 â—¼   ENZYMATIC_REACTION ✅ 57.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
TNF CXCL1 â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10925299 11112697 11438547 11875494 12646658 12811837 1431106 14607933 14625680 15099563 15699106 16713974 17916596 18633355 19411070 20038811 20184663 20435894 21133840 21411734 21826665 22595692 22955274 23170255 23430059 23508573 23510023 23567181 23769623 24092389 24378531 26201938 8910423
SP1 TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 23733894 12759366 27030318 22534375 7649977 12509451 12378384 15175554 18357389 10829018 11390427 17897957 18218727 8258705 12560487 17047073 21320120 7918637 16847329 10559188 18930140 20068037 1618817 21784970 10688670 10913190 17307735 18467438 21411747 11500175 20221720 20701940
SPI1 TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 18802049 10748079 19646961 8998076 18408586 18357389 25567680
JUN TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 12759366 11087751 7935377 21059644 16881863 24548427 12509451 9826775 10318823 8998076 18408586 15546613 20164416 7896795 9211933 10952728 9566900 23583459 10748079 24009130 10954918 10754326 9813054 10837498 9988757 11739517 16365438 19285436 16199883 8816436 10551799 8552071 9160673 11490006 21098092 16483936 10688670 10913190 16888805 9030359 25567680 9760243
CEBPB TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 10775602 21059644 9831247 26114754 19530226 20220144 9566900 10748079 19489038 8726660 10754326 19109189 10838190 14514692 24012417 12184911 23971673 23590297 14976147 16850160 10629048 22074460 15850785 7929820 10887174
RELA TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 136.0 1.0 Omnipath 26596471 17707233 20817730 12686724 27075886 21765477 21537341 19530226 17390058 18077329 15064230 20617556 8805669 17351769 23335080 21573233 17292554 16285952 9916895 11749970 7895918 17496784 12628924 23857586 12657243 15857826 12471036 11259437 16433741 9831247 20237317 15465827 26023919 22661093 10748079 15013838 17350185 10754326 15470505 11827962 20139176 26408955 22901690 18772140 21108432 22742857 23195252 18362169 24012417 11312646 17442180 9281604 10079106 11297551 15081318 22718766 24908318 8219230 26004152 11094063 11490006 9916692 16483936 18057724 16569682 22138107 18467438 20547752 22723832 19846753 17407192 20221401 19854828 20534538 7876168 16707469 12117498 20544543 23178569 15812247 21138578 12610112 25888873 16916598 16040075 28039105 14749357 20066113 19285436 25161822 22388040 14960579 20195282 16199883 15543947 23971673 10551799 11290773 22798670 22021035 20722069 20221720 27338466 19385047 12058956 26997758 25690886 7624137 20686703 26114754 14976218 10485496 17607667 8622636 11007957 18285351 10837498 11739517 18719026 17268554 17085785 17142966 10963848 9742085 23042817 27534992 10553096 26516703 20696864 10201927 16850160 8679226 21098092 20097764 9129150 17082635
TNF RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 39.0 1.0 Omnipath 15192014 27329558 22240205 15833743 19351843 28187781 15841081 28107185 28373828 26999213 24386331 24957606 26179215 21572963 18258304 28317833 29441018 10722927 19596989 28423685 12881425 25118327 24036851 28089769 21904602 24141032 10938077 30201812 20691659 24166907 19789307 19393267 22768286 26310932 19411070 23789107 28790310 29708974 20507904
MYCN TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 20811720 11107122 10050884 21862876 20145147 19885598
RELA TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 18269916 10348347 11032029 8051093 20061391 15155458 21332394 9890939 21887328
JUN TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 22859294 17321721 20697347 10348347 12963547 10072388 22353755 18604200
CEBPB TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19135161 23564453 19075931 24333671
TP53 CHUK â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15469934 11557753 17434128
TP53 MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17311279 15899818 17077165 18635530
TP53 CCNA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 16931621 8270002 9275177 19671680 16571800 8641461 9360984 21952947
TP53 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 12732139 10618379 22264233 23706820 14514686 8183578 14761612 16138117 18593586 23063463 8119773
TP53 SP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 19846904 15790310 11118296 11384995 21611785 7478550 15967108 18419600 19244234 9865734 18769160
TP53 CASP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16135520 12459463 15580302 21943362 11278253
CCNA2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14640983 10884347 16713569
IRAK2 CCL2 â—¼   ENZYMATIC_REACTION ✅ 25.0 1.0 ACSN 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 9743347
MYD88 CCL2 â—¼   ENZYMATIC_REACTION ✅ 25.0 1.0 ACSN 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 9743347
IRAK4 CCL2 â—¼   ENZYMATIC_REACTION ✅ 25.0 1.0 ACSN 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 9743347
CD14 CCL2 â—¼   ENZYMATIC_REACTION ✅ 25.0 1.0 ACSN 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 9743347
RELA CCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 60.0 1.0 Omnipath 24337575 10644332 22189654 18226221 20038977 8630731 12488502 19738286 22189669 14976218 19371341 12540607 24260304 11716760 21138578 8617886 12218154 14631383 20952659 17452470 16325549 10744656 15223809 10530453 11006087 16040075 16730843 23583295 24063814 27076634 10987310 16206198 9388261 10614622 18353872 16166627 16829531 16818736 10636866 20195282 10469356 17507908 12647268 12682245 21106671 24550391 16764699 17932106 25108845 20200316 15950427 24634218 9174597 23198981 11949945 9916692 17537731 22723832
JUN CCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 19162185 18024959 18443042 14752027 22674286 23583295 19299558 12667961 10918580 19371341 26554515
SP1 CCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 10792620 10644332 17255531 8630731 10636866 16847329 10657660 23349788 12787135 12488502 12682245 25108845 8051410
CEBPB CCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17180354 10748205 20019816 12145301 16784777 17390372 18649942 20730378 19026986 15710476
CSF2 CXCL1 â—¼   ENZYMATIC_REACTION ✅ 21.0 1.0 ACSN 10426994 11015446 11280761 11460167 11777960 11907067 12193690 12907458 14660645 15536084 16713974 17301840 18264787 20805416 21133840 21232017 21765015 22869907 24030977 24699077 24958845
RELA CXCL1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 16799643 8530498 15958549 10530453 16617094 16040075 25734337 11112786 16825293
SP1 CDKN2C â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18642058 15107822 22504641 12077144
HOXA9 MEIS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10082572 15161102 9343407
MBL2 MASP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 22607836 9087411 20956340 22854970 10878362 21035894 25579818 27104295 19939495 32041782
TGFB1 ID2 â—¼   DOWN_REGULATES ✅ - 27.0 1.0 ACSN 11133108 11708773 12490555 14557817 15111329 15181457 15252039 15548370 16474430 16607286 16716598 17615296 17934056 18403754 19010789 19109155 19920116 20519943 20644162 21041997 21278795 21900405 21909923 22703233 7594497 9157999 9335507
CEBPB C3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 25617152 22171262 21308746 18247123 10594926
CFI C3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 16023208 1401896 26806831 9291131 8648130 2141838
CFH C3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 16023208 19050261 11367533 21979047 21317894 9988761 16612335
C3 C3AR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 8702752 11342658 8765043 20527893 9476119
CD14 IRAK4 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 19592493 20485341 11960013 18829464 12297423 19498957
FGG IRAK4 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 19592493 20485341 11960013 18829464 12297423 19498957
MYD88 IRAK4 â—¼   PHYSICAL_INTERACTION 37.0 1.0 ACSN 10679398 11274345 11592085 11964313 12620219 12682231 12907458 14504095 14607900 14660645 14662834 15099563 15749884 15749903 15802534 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 18977329 19161412 20547845 21372296 21826665 23508573 23681101 23811849 26885855 27048821 27066895 9469432 9743347
IRAK4 IRAK2 â—¼   PHYSICAL_INTERACTION 25.0 1.0 ACSN 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 9743347
IRAK4 CD14 â—¼   PHYSICAL_INTERACTION 25.0 1.0 ACSN 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 9743347
MYD88 IRAK4 â—¼   SHARES_COMPLEX 37.0 1.0 ACSN 10679398 11274345 11592085 11964313 12620219 12682231 12907458 14504095 14607900 14660645 14662834 15099563 15749884 15749903 15802534 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 18977329 19161412 20547845 21372296 21826665 23508573 23681101 23811849 26885855 27048821 27066895 9469432 9743347
IRAK4 CD14 â—¼   SHARES_COMPLEX 25.0 1.0 ACSN 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 9743347
IRAK4 IRAK2 â—¼   SHARES_COMPLEX 25.0 1.0 ACSN 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 9743347
IRAK4 CXCL2 â—¼   ENZYMATIC_REACTION ✅ 25.0 1.0 ACSN 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 9743347
MYD88 IRAK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 20485341 15084582 19167362 12150927 17486091 26871637 25502805 24316379 16189514 18221795 15905496 25910212 12538665 16410796 22011580 12860405 12297423 32296183 17507369 11960013 24735611 20966070 17548806 31515488
MYD88 CD14 â—¼   PHYSICAL_INTERACTION 26.0 1.0 ACSN 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16267105 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 9743347
MYD88 IRAK2 â—¼   PHYSICAL_INTERACTION 25.0 1.0 ACSN 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 9743347
MYD88 IRAK2 â—¼   SHARES_COMPLEX 25.0 1.0 ACSN 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 9743347
MYD88 CD14 â—¼   SHARES_COMPLEX 26.0 1.0 ACSN 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16267105 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 9743347
MYD88 CXCL2 â—¼   ENZYMATIC_REACTION ✅ 25.0 1.0 ACSN 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 9743347
SP1 MMP9 â—¼   UP_REGULATES ✅ + 21.0 1.0 ACSN 10048576 10964912 11007770 11013220 11114293 15001984 15592504 16079281 16556862 16716598 16831886 17490644 17705132 18353785 18832382 19564415 20589835 21252118 22439866 23338822 8844971
JUN MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 16798740 16554298 11774399 15949416 11429784 15777790 16014933 10935492 11326313 18809380 21474819 21963718 19455716 9136992 17572495 23176293 15708369
RELA MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 48.0 1.0 Omnipath 18298869 12105194 11376631 14600595 17673602 23423566 17922642 15605368 14755547 20332461 18357389 21502320 17186550 11060311 18566231 9679762 16554298 16687076 17121934 15086314 18843978 21963718 18056465 20103608 21238464 17174275 15536164 18028425 17158602 17590163 19303700 7860222 19539355 9500201 22587999 19783786 18567920 15175338 17498959 19616091 10359016 18801463 19454280 24755270 19662350 12193473 16014933
SP1 MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 8226872 24755270 18028425 9514098 9520415 23799155 20529870 21840940 7860222 17049831 21963718 18357389 9150367 11060311 19616522 11830485 9748266 20638438
MMP9 TGFB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10652271 21900405 25241761
CEBPB CCL5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11937564 11413310 12388374 16239564
RELA CCL5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 12820969 11478739 17510282 19786024 12050170 21138578 12122011 19828633 18367595 22030901 18502824 16707500 10926836 11413310 20663893 22388040 15144466 9120310 12603855 26096887 11259372 21189258 12388374 15972972 11389171 25523420 18525004
JUN CCL5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 11413310 10760799 19828633 10075858 20862675 26096887 7513046
CYBA CYBB â—¼   PHYSICAL_INTERACTION 25.0 1.0 ACSN 10679059 10714681 11062502 11146654 11385609 11747822 11907067 12626562 12740575 14697347 15169870 15184873 15536084 15927447 17517963 18423981 18809714 19372727 19380816 19732719 21178402 21383238 22157818 22827577 27331412
CYBA CYBB â—¼   SHARES_COMPLEX 25.0 1.0 ACSN 10679059 10714681 11062502 11146654 11385609 11747822 11907067 12626562 12740575 14697347 15169870 15184873 15536084 15927447 17517963 18423981 18809714 19372727 19380816 19732719 21178402 21383238 22157818 22827577 27331412
TGFB1 PDGFA â—¼   ENZYMATIC_REACTION ✅ 27.0 1.0 ACSN 11133108 11708773 12490555 14557817 15111329 15181457 15252039 15548370 16474430 16607286 16716598 17615296 17934056 18403754 19010789 19109155 19920116 20519943 20644162 21041997 21278795 21900405 21909923 22703233 7594497 9157999 9335507
RELA TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 19385047 23195252 28148567 14600158 16365456 21255844 15051419
JUN TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 8058069 16327802 16730810 23437118 8183578 16365456 22429882 23936544 15546613 10843986 16978906 23762330 7521696 8631909 12794825
SP1 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 12186868 9580699 2808430 12615726 22415074 27974707 12138160 10964912 9242631 15178441 23437118 23936544 11114293 8325508 16714330 11278686 10212284 9837963 11054406 23806282 15979845
TGFB1 PDGFA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 19010789 16474430 17934056 18403754 20519943 16607286 21900405 11133108 14557817 15548370 19920116
ZEB1 TCF3 â—¼   UP_REGULATES ✅ + 22.0 1.0 ACSN 10048576 16556862 17012742 17486063 19208835 19839049 19935649 20589835 20702634 20706219 21051859 21081489 21159887 21224848 22286765 22439866 225147423 22514743 22945800 24335145 28212565 9811054
ZEB1 BMI1 â—¼   UP_REGULATES ✅ + 22.0 1.0 ACSN 10048576 16556862 17012742 17486063 19208835 19839049 19935649 20589835 20702634 20706219 21051859 21081489 21159887 21224848 22286765 22439866 225147423 22514743 22945800 24335145 28212565 9811054
HDAC2 SIN3A â—¼   PHYSICAL_INTERACTION 8.0 1.0 ACSN 14673164 15465827 17018611 17563753 21234400 21577210 22514743 22796940
HDAC2 SIN3A â—¼   SHARES_COMPLEX 8.0 1.0 ACSN 14673164 15465827 17018611 17563753 21234400 21577210 22514743 22796940
RELA CXCL8 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 15079071 15536066 17550372 19171876 23430059 8383323 9743347
CEBPA CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22685373 25119735 8999951 18199703
JUN CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 37.0 1.0 Omnipath 18684922 16701870 24048734 14686613 24284797 15057743 12643600 17197543 11864912 10817569 12218154 22031759 17586662 10969814 19064995 12716652 27856305 25582859 17471497 22095787 16818736 23176534 14670967 18435575 16846747 19734226 16299055 14612204 18772138 19132242 12209633 15939312 16834785 11399048 11120852 25567680
RELA CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 129.0 1.0 Omnipath 12820969 24337575 15289496 9405619 9698090 20038977 15057743 21665565 24260304 10817569 14631383 10969814 15005855 19668231 16325549 19732956 8207232 18281166 27856305 23894194 9388261 26340924 10975857 10745031 20194077 10928981 16553947 17565687 16764699 22848596 15531761 16105834 16803583 9510190 15355994 18221537 12643600 20053934 11716760 8617886 12218154 12707271 23637609 27076634 8878392 17917246 12163591 16829531 16818736 14670967 12038622 15958549 18362169 8413215 19734226 23386688 11297551 15950427 17362989 16455661 27371733 11953364 8413306 18074095 11973337 18786178 19376732 19837667 17276517 15517885 11342414 18669446 7876168 15350531 14645117 22891766 18034886 11564889 12748173 17586662 18996370 15223809 17041011 12485925 16004996 15079071 21343296 26618242 18435575 17636245 22340043 19173296 24634218 11120852 10477716 21343177 12058956 17045242 19786024 24048734 24770886 10202011 18309103 11864912 21131967 19064995 10530453 12716652 16418726 28283022 18723827 17040605 21255844 15615716 17932106 19966855 20696864 15387324 21451502 15722553 15879558 12855659 12883201 15688424 18045535 10506755
CEBPB CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 23051921 10775602 17135982 8969274 17997161 18512730 21471847 24554449 14645117 15085176 17845418 12707271 12748173 19489038 22031759 8234276 19064995 8207232 16989899 27856305 11991987 19109189 17471497 19786303 16809637 16818736 21255844 19734226 24038085 18772138 19805069 20861254 18487355 11390611 15688424 10462040 16803583 8999951 11120852
SP1 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 20148354 8355696 8892460 1406636 19437621 9054614 17502875
MEF2C JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9069290 9252389 10523670 11158308 7760790 10849446 12054430
JUN CSF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 9190901 12760745 19890352 1900839 8135780 11509589 8524292 7579683 10330159 9862439 15840658
JUN CCNA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9486962 23385061 15574764 17182846 15737994 21069729 9511728 20531301 21029732
JUN SPI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17283046 10411939 9178763 9988737
RELA JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18174238 9468519 16713569 10488148
JUN CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 18813803 19219074 16406505 16880536 16054035 19190345 17000779 17439715 8545107 16396903 11274345 20107231
JUN SPI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12393465 10411939 12091339
CASP1 NLRP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 21252346 12191486 15383541 17418785 15107016 11051551 11536016 11432859 18511561
CARD18 NLRP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11051551 11536016 11432859 15383541
NLRP1 CASP5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17418785 12191486
ATG5 CASP8 â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 11003656 15325588 17462996 20531300 23725295 24070470 26587781 26972597 28574505 9488730
ATG5 ATG12 â—¼   PHYSICAL_INTERACTION 7.0 1.0 ACSN 22093031 22166994 23030059 23301705 23725295 24070470 24257061
ATG5 ATG12 â—¼   SHARES_COMPLEX 7.0 1.0 ACSN 22093031 22166994 23030059 23301705 23725295 24070470 24257061
ATG5 CASP8 â—¼   SHARES_COMPLEX 10.0 1.0 ACSN 11003656 15325588 17462996 20531300 23725295 24070470 26587781 26972597 28574505 9488730
ATG12 ATG5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 11825910 20562859 17145710 12890687 17353931 22342342 9759731 9852036 23202584 11265251 12207896 12482611
ATG5 ATG16L1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 20562859 23262492 22342342 20639872 23392225 12665549 23202584 18448665 25484072 28594407 10406794 21575909 22847423
CD14 CASP8 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 21737330 12752666 15814722 16115877 14739303 21737329
CHUK CD14 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15064760 15814722 16115877 16603398 16547522
CHUK TICAM1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15064760 15814722 16115877 16603398 16547522
CHUK RELA â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 9315679 9914500 9721103 10593898 9135156
CHUK NFKBIB â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 9315679 9914500 9721103 10593898 9135156
TAB1 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14960582 18855897 11274345 20194509
CHUK RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 49.0 1.0 Omnipath 17145710 15611276 22110409 19609947 10521409 20863851 20051109 20363318 12767944 26999213 12842894 21903422 19110719 15858576 16382138 22155370 23894194 16046471 15128824 21569639 16846590 8246997 15485852 25341660 15494311 11983155 15980040 15489227 15849198 14636585 23343355
CHUK NFKBIB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 32.0 1.0 Omnipath 17145710 8657102 15084594 9315679 9252186 14743216 9278383 9914500 15836773 9721103 23109003 9689078 15145317 10723801 29145629 9135156 10593898 14636585 17072322 29695914
SP1 RELA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 7636984 8450395 9151857 20538607 11964305
RELA CSF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 9414129 7636192 9190901 11418664 18230685 9596659 8135780 21071440 14741709 11395507 8934574 18285351 10608823 18056447
RELA DEFB4A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16417227 21518253 12682256 11207625
RELA CXCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 14597166 27889620 24634218 15722553 15666090 17363596 17449583 21507677 18362169 28266569 15132979 27076634 12914794 16166378
RELA BIRC3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 15231833 15050749 19343319 17673602 18226221 23250755 17000776 11880364 21279667 21765477 10733571 18566231 12010810 15723831 10823821 11297551 16291753
RELA BIRC2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15050749 17673602 12687011 12714587 15756023 12010810 18566231 16453001 20103608
RELA CD86 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10586028 12574356 15949284 19164127 15895390 18929846
RELA CD40 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11313274 17031478 19164127 9733827 10075983
RELA SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12055073 7933095 10671503 20861353
RELA NFKBIB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 22081069 10497169 12672800 21988832 14685242 14743216 16189514 16226509 26186194 11571291 10498867 15371334 8816457 8887627 15145317 9135156 16513645 9597130 14636585
IRAK2 CD14 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 21606490 11544529 17890055 19679662 20485341 17878161 16024789 19224918 20400509
CD14 IRAK2 â—¼   PHYSICAL_INTERACTION 25.0 1.0 ACSN 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 9743347
CD14 TAB3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 15327770 19675569 16115877 10882101
CD14 TAB1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 15327770 19675569 16115877 10882101
CD14 TICAM1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 14517278 12242293 19656901 12855817 14556004 12609980
CD14 IRAK2 â—¼   SHARES_COMPLEX 25.0 1.0 ACSN 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 9743347
CD14 CXCL2 â—¼   ENZYMATIC_REACTION ✅ 25.0 1.0 ACSN 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 9743347
SP1 CD14 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11698458 17203216 12213324 7512565
IFNA7 IFNAR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21856167
IRF9 IFNAR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17923090 18456457
SPI1 CYBB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11241298 15618156 9593745 11926990 10233904
HOXA10 CYBB â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16210632 15681849 15496449 17439948 10766757
SP1 SPI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12706891 22734486 10446912 7478579
CEBPA SPI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17671233 24429361 14636649 20972335 12949251 14592841 12032776
SPI1 FCGR1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12393465 7869026 8035786 12130529 15304324 14734612 10820245
SPI1 CD40 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10823830 11481336 14962802 19801646
SPI1 CSF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17116688 8264604 9506963 8302571
SPI1 FLI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10523830 9858537 23056458
CEBPA SPI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10397723 12091339
TAB1 TICAM1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 15327770 19675569 16115877 10882101
CD40 CD86 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 11207245 11581322 11698286 11964292 14764699 15034038 15197224 17200410 17317815 17371980 17513775 23002440 23125331 7523569 8760829 9359474
CD4 HLA-DQA2 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
TICAM1 TAB3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 15327770 19675569 16115877 10882101
SP1 CCNA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15922873 10196209
SP1 PDGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 15297375 9453298 9321833 9351401 22964636 7499234 10364563 11823426
SP1 CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11160217 9339900 19753117
SP1 LDLR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 24358207 14568562 7836375 11250935 10894816 9610768 11792717 16647292 7597088 14998783 7627719 10841543 16303770 9271397 10224053 16449644
SP1 MYCN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 14567977 22815527 21123453 14645238
TCF3 PTCRA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11490000 17050604 11870636 12566462
CD40 BIRC2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 19426221 12374738 24298274 9718306
CD40 BIRC3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 19426221 12374738 24298274 9718306
CD40 TRAF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 20614026 17145710 21041727 9133417 7859281 12637493 10352240 16260598 15485859 24810049 17878343 9384571 7530216 12220533 18635759 14517219 9990007 24260396 10428814 17332487 19667091 7533327 9168896 10984535 27716849 9718306 10318845 11562359 7527023
TICAM1 TRAF3 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11672593 11964313 12032143 12811837 15644117 16306937 16917499 17114424 20154735 20547845 23508573
TICAM1 TRAF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17327220 16306937 16306936 17991829 18450748 24577058 20418377
IRAK2 FGG â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 21606490 11544529 17890055 19679662 20485341 17878161 16024789 19224918 20400509
IRAK2 CXCL2 â—¼   ENZYMATIC_REACTION ✅ 25.0 1.0 ACSN 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 9743347
CEBPB CEBPA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 9990015 19581927 10603305 15509789 16431920 19663997 15110775 7862113 10854425 17301242 24216764 20179325 15158467 17646392 18622014
CEBPB LDLR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12235180 16563127 19804198 12947119
HLA-DQA2 HLA-DMA â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 9606180 7481823 9075930 9311912 7667286 8046351 10631952
CARD18 CASP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 15383541 27043298 11051551 11536016 11432859
CARD16 CASP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11536016 11432859
CASP1 CARD8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 15383541 11051551 11821383 11536016 11432859 15030775 19337385
CASP1 CASP5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11051551 11536016 11432859 15383541
C5 C5AR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 35.0 1.0 Omnipath 9881961 11773063 9553099 15661745 10602324 1847994
CARD18 CARD8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 15383541 11051551 11821383 11536016 11432859
CARD18 CASP5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11051551 11536016 11432859 15383541