Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
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Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
NR3C1 ATF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17016446
ATF2 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11243868 19948881
ATF2 CYP19A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21393445 12520731
ATF2 IL13 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19487697 22849952
CDK2 NR3C1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9199329
NFKB1 COL1A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11277268
COPS5 FOS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19180539
HIF1A CXCL12 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12384916
CXCL12 DPP4 â—¼   CLEAVAGE ✅ 2.0 0.8 intact 21314817 8090457
RUNX1 EP300 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16917507 5218981
TBX21 EP300 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0607926103 17075044
NFKB1 EP300 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12456660 16135789
EP300 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23403292 24998469
EP300 SPP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20339243 21467818
EP300 WT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15752709 18064385
EP300 COL1A2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19828133 24058639
EP300 RELA â—¼   ACETYLATION ✅ 2.0 0.8 intact 5214468 11533489
MAPK3 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24530506
EP300 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16374512 11433299
EP300 VDR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21988832 20089040
FOS ICAM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11356008 9218873
TNF ICAM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21474822 22846676
MAPK1 L1CAM â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10608864 10818153
FOS MAPK1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7588633 12134156
AR MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14619959 20610535
HGF MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16397249 17667909
MAPK1 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8941362
MAPK1 MAP2K3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 16709866
MAPK1 L1CAM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17151951 21080252
MAPK1 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15778365
TAB1 MAPK14 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5215125 11847341
MAP2K3 MAPK14 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8622669 7535770
USF1 MAPK14 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18817855 12970752
MAPK14 RB1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 17380128 5219804
MAPK14 FOS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18253836
FOS MAPK3 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7588633 12134156
MAPK3 IRS1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7739560 8816480
HGF MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16397249 17667909
EGF MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17081983 16024629
MAPK3 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16888388 16691505
MAPK3 GATA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22227582 11585926
RB1 MDM2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218170 16374512
SUMO1 MDM2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12393906 20972456
HIF1A MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12606552 15385570
FOS MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10348347 12173040
FLI1 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15592502 20153576
SUMO1 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12393906 11384992
RPS6KB1 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20657550
MDM2 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21988832 23839035
SUMO1 PIAS4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20023648 22508508
RELA PIAS4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0701877104 17606919
PIAS4 VIM â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
PIAS4 PTN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
PIAS4 SKIL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
AXIN1 RNF111 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16601693 5218493
RNF111 SMURF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
VIM SKIL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SMAD4 SKIL â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22674574
SKIL SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12419246 12426322
PDPK1 STRAP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16251192
HDAC4 SUMO1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12032081 18691969
YBX1 SUMO1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20596676
SUMO1 SRF â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12788062
ARNT TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15627257 23359428
TBX21 TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24006458 21983879
IRF8 TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18802049 19718038
TTF1 TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10499522 21784970
TNF PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22078880 20651683
TGFB1 UCHL5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22344298 16027725
YBX1 IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12446674 8163940
YY1 EPAS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19483472
YY1 TAGLN â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12023898 16314465
YY1 NR3C1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12039077 10030686
YY1 TBX21 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 21272048
JUN COL1A2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8621730 12384935
HIF1A IL10 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17504662 15723200
SMAD4 IL10 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14557415 21728174
SMAD4 IL10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20154735
IL10 NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12773629
IL10 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12773629
HOXA9 SPP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 21294585 11042172
VIM RBM39 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
VIM TIMP3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
SMAD4 DACH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 14525983
VEGFA CDC42 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12810700 12215529
VEGFA SHC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10749680 12214271
AHR VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17413038 19182260
FOS VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12163680 11353786
GATA4 VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19501129 17975667
IL7 HGF â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11564764 12184921
SMAD9 SMAD4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
SMAD5 SMAD4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
FOS SMAD4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11854297
SMAD4 AHR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11259615
SMAD4 BAMBI â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15240101
SMAD4 TNC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15001984
SMAD4 IHH â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14981086
SMAD4 SPP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21294585 11042172
SMAD4 MET â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15339794
SMAD4 TNFRSF11B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11451955
CREBBP SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9679056 9679060
EIF4E SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12150994 23331499
SMAD4 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9679056 9679060
FOS PLAU â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11774399
RUNX1 IFNG â—¼   DOWN_REGULATES ✅ - 2.0 0.8 ACSN 15084276 18003603
AHR IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19461128 16289099
PPARG IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19160541 15187132
PPARG NOX4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 31023188 20622120
HIF1A PTEN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18340011 19648120
RELA PTEN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 14729949
CDC42 PTEN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 16381926
PTEN PDPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11943559 23331499
TGFB1 BAMBI â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10519551 19758997
AHR CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17823304 18289803
JUN MAPK8 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 18793328 10871633
HIF1A JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15794924 19828020
RELA JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17310108 10646503
JUN AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12832543 11192249
JUN ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21384344 16786139
JUN VDR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15930183 17121851
JUN AGT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath
JUN IL13 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21989417 15494506
JUN CYP7A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11278771 16729332
JUN LPL â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath
JUN HSPB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12832543 20566634
JUN TNC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9154819
JUN PTN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16199533
JUN MBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20720108 11226757
JUN PTGS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17138645
RELA CFTR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11114294
RELA EPAS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20495570
RELA CDK4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18425349
RELA TBX21 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17407192
FOS RELA â—¼   PROXIMITY 2.0 0.8 intact 18172215 0705181105
RELA FOS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16189514 10488148
PPARG TXNIP â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19808645
PPARG FST â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17592024 18768463
PPARG CYP7A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath
PPARG IL4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19217272 14573767
PPARG SPP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11861425 11426586
PPARG PTGS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18309368
AR IL18 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15178407 20610535
FOS IL18 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15543578 10975835
FOS SPI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9988737
SPI1 RB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14559995 12588990
SPI1 MET â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24503536 19423615
RB1 SPI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 8434021
SPI1 CSF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15676205
NR3C1 IL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9510064 2159467
FOSB IL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7989759 9171236
TBX21 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0607926103 17075044
NFKB1 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12456660 16135789
HIF1A CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17382325 5219810
CREBBP VDR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10406465
CREBBP ARNT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12573436
RUNX1 IL4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19689732 17195845
AR IL4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20610535 23554843
HIF1A UTS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20616367 22399808
HIF1A SPP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17848618 19016748
HIF1A AVP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16507742 12691740
HIF1A NR3C1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15699159
CDC42 RPS6KB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5214238 11438723
CDC42 MAP2K3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11704645 14724572
CDC42 RPS6KB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11438723
CD28 PIK3CG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9915850 18006698
FOXP3 PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16785520 24308961
FOXP3 FCGR3A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20554955 19494275
NFKB1 TBX21 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17407192
TBX21 CD8A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20060330 25148025
AR SERPINE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1384159 20610535
SERPINE1 PLG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11113116 16713569
NFKB1 TNC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20723226
AR PTGER2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12933667 20610535
TXNIP SMURF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMURF2 SMAD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMURF2 SMAD5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
EGF ERBIN â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23220880 22908275
EGF MET â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20178463 17081983
AHR SPP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22037483 15735673
NR0B2 PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21613300 18775915
LEF1 PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19783677 17945188
ERBB2 PTGS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19861462
AR IRS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18521741 20610535
EPAS1 IRS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15258146 17202795
AR IGFBP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16825320
RPS6KB1 AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5214238 11438723
NFKB1 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18031796
MAPK8 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16306447
RB1 FOS â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 1909121 7680889
FOS EDN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21239258 1918021
FOS CYP19A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19022561
FOS NTF3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7733919
FOS NFKB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20188076
FOS EDN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9588211 16716598
RUNX1 NFKB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19686049
NFKB1 CYP19A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15459115
NFKB1 CFTR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11114294
NFKB1 TLR2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19779021 12686724
NFKB1 LPL â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20200316
NFKB1 EDN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21334436
LEF1 FN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23677615 17452626
NR3C1 FN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16303956 3611064
RUNX1 IL17A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21151104 18849990
SMAD9 SMAD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8893010 11779505
SMAD1 CTDSP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0605133103 16882717
SMAD1 SMAD5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD1 MED15 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12167862 5215637
SMAD1 NEDD9 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
AR SMAD1 â—¼   COLOCALIZATION 2.0 0.8 intact 5219486 17183365
HDAC6 GRK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22193721 8383707
GRK2 HDAC6 â—¼   COLOCALIZATION 2.0 0.8 intact 22193721 8383707
ERBB2 SHC3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
TTF1 ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11036938 11161473
ERBB2 SHC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16273093
AR VDR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15805579 16425262
AR SLC2A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17426252 20610535
AR AHR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20610535 23689136
AR MBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20610535 7657701
AHR AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19815066 17392787
AHR HSPB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 14973392 11174852
USF1 NR0B2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19720831 21147283
USF1 CYP19A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12917334
GRK2 CCR5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10085131
AHR IGFBP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18055878 18827440
NR0B2 AGT â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19887897 14672953
TTF1 AGT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12730191 18395010
AHR L1CAM â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17903170 17707923
AHR IL17A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21266768 21266776
NR3C1 SFTPA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17003084 18079322
ARNT SMAD9 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
WWP1 SMAD5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD9 SMAD5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8893010 11779505
LEF1 FST â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24344199
GATA4 CYP19A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22245270 17227882
GATA4 AGTR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9207128 10579051
SRF GATA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11003651 11158291
LEF1 VDR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17517646 0702884104
CCL11 DPP4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6491341 18275857
DPP4 CCL11 â—¼   CLEAVAGE ✅ 2.0 0.8 intact 21314817 8090457
SMAD9 FLI1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SRF FOSB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22649236 10925151
F2RL1 F3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0606411103 16959886
KLF10 TGFBI â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18359287
SPTBN1 SMAD9 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
NKX2-1 TTF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11046146 9588495
MAPK14 TAB1 â—¼   PHOSPHORYLATION ✅ - 0.8 0.8 Signor 19393267
NFKB1 EP300 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 11739381 23811396 14662860 12471036 20065107 22013068 12960163
AKT1 MDM2 â—¼   PHOSPHORYLATION ✅ 0.81 0.81 mint 5217292 15527798
MDM2 AKT1 â—¼   PHOSPHORYLATION ✅ 0.81 0.81 mint 5217292 15527798
PTEN WWP1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 33470109 21532586 25547115
CDC42 MAP3K11 â—¼   PHYSICAL_INTERACTION 811.0 0.81 STRING 36370105
EP300 ATF2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 10327051 24069158
FOSB ATF2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 32296183 33961781
EPAS1 EP300 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 23275444 15261140 22807441 25689462
HDAC6 EP300 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 19344692 15102857 12718889 22778253 23133622
EP300 SMAD5 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 16516194 16613856
ICAM1 PAK2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
EPAS1 SUMO1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 20026589 20661221
SMAD4 SMAD6 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 15817471 9256479
TAB1 MAP3K7 â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 5218828 16845370
NFYC NFKB1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
SMAD1 LEF1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 10890911 15750622
RBM39 HSPB1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28302793 25277244
DPP4 CCL11 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21314817 11390394 18275857
MMRN1 ECM1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 26186194
EP300 STRAP â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 30110629 18451878 33742100
MAPK3 HSPB1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 25241761 21575178 8774846
PIAS4 SMAD1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 16189514 15231748 12904571
PDPK1 STRAP â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 17916563 16251192
SMAD4 JUN â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 10220381 25609649
HDAC6 CFTR â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 31501480 22069321 14675537
AKT1 MAPK14 â—¼   PHYSICAL_INTERACTION 830.0 0.83 STRING 36370105
EP300 FOS â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 19064921 21937452 11287611 24069158
MAPK14 RB1 â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
SUMO1 PIAS4 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 20016603 15831457 16524884
FOS PIN1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 16123044 32296183
NR3C1 RELA â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
PDPK1 SDC1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 32707033 31980649
AKT1 IRS1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 10497255 17640984
CREBBP NR3C1 â—¼   PHYSICAL_INTERACTION 845.0 0.84 STRING 36370105
FOXP3 IL2 â—¼   PHYSICAL_INTERACTION 848.0 0.84 STRING 36370105
RUNX1 EP300 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 14752096 16917507
EP300 SMAD1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 10205054 20851880 22365546 16613856 10673036
AXIN1 SUMO1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 22509369 18632848 26871637
SUMO1 ACTN1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 15576338 19596686
HIF1A JUN â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 25879517 19738058 11739718
SPI1 JUN â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 12091339 9681824
MAPK8 JUN â—¼   PHOSPHORYLATION ✅ 0.85 0.85 mint 7148309 19527717
AKT1 ARNT â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 15833858 28628118 28205554
CFTR HSPB1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 26627832 17110338 29924966 26618866 23155000
EP300 FOS â—¼   PHYSICAL_INTERACTION 850.0 0.85 STRING 36370105
AKT1 PTEN â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
SMAD4 SMAD5 â—¼   PHYSICAL_INTERACTION 853.0 0.85 STRING 36370105
SMAD1 SMAD6 â—¼   PHYSICAL_INTERACTION 855.0 0.85 STRING 36370105
AHR RB1 â—¼   PHYSICAL_INTERACTION 858.0 0.85 STRING 36370105
SMAD4 EP300 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 9679056 25514493 18215124 9843571 14612423 10887155 22033265
PIAS4 LEF1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 11731474
AKT1 PTEN â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 12297295 19903340 12077256 28628118 20605778 28205554 10866658 20596030
HDAC6 ERBB2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 20029029 31980649
SDC1 PTN â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 7592855 16713569 8175719
IRF8 SPI1 â—¼   PHYSICAL_INTERACTION 865.0 0.86 STRING 36370105
CREBBP MDM2 â—¼   PHYSICAL_INTERACTION 866.0 0.86 STRING 36370105
JUN MAPK1 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
GATA4 EP300 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 18252717 27208796 11481322
AKT1 EP300 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 21901101 15224190 21775285 20333651 18182168 11116148
SUMO1 MDM2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 21316347 12917636 22411991 18583933 15876874 12393906 12297306 20972456 11384992 15876864 17000718
DACH1 JUN â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 17182846 25609649 16980615
SMAD5 SMAD4 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 10531362 16516194 16189514 15231748
ITCH JUN â—¼   PHYSICAL_INTERACTION 869.0 0.87 STRING 36370105
ITCH JUN â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 17110928 16901904 19818398 19806201
PPARG HDAC4 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 12943985 21605119
TXNIP WWP1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 29378950 33961781 31340145 29635000
AKT1 AR â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
EP300 NFKB1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
EP300 MDM2 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
MAPK1 MAPK14 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
HIF1A MDM2 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
HIF1A VEGFA â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
CTDSP1 MBP â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
EP300 PPARG â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
UCHL5 YY1 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
IL10 YY1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HuRI 32296183
AHR EP300 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10999956 17392787 21988832
EP300 VDR â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 32603375 15647825 20089040 21988832
NR0B2 MDM2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 33889569 22575647 22197810
PIAS4 SMAD4 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 12815042 12740389 12904571
RBM39 JUN â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 11704680 25609649
JUN RUNX1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 11641401 11274169
AKT1 PDK1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 27166089 27505672 34278744
FOS RUNX1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 11641401 11274169
GATA4 SRF â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 11158291 11003651
AR EP300 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
MDM2 RB1 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
EP300 SMAD4 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
EP300 YY1 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
AKT1 EP300 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
MAPK1 MAPK3 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
CREBBP JUN â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
PIN1 JUN â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 29225075 11432833 16713569
SMAD4 SMAD9 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 32296183 16189514 10583507 25502805 25609649 31932471 15231748
NR0B2 PPARG â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11696534 16189514 19596656
AKT1 HSPB1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17510053 31980649 12740362 11042204 23397142
TXNIP ITCH â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 29378950 26527736 20068034 27437069 32901881
SMAD6 SMAD1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11483516 12857866 9436979 9256479
EPAS1 ARNT â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 24981860
SMAD5 WWP1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16713569 16189514 15221015 15231748
INHBA FST â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 7887917 16198295
CREBBP RELA â—¼   ACETYLATION ✅ + 0.89 0.89 Signor 16382138
ATF2 FOS â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
SMAD1 SMURF2 â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
TAB1 TAB2 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
JUN ATF2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 8027667 20102225 28514442 16511568 23661758 15546613 26496610 2320002 20195357 10327051 1827203 9445037 20511396 10207054 25609649 33961781
FOS ATF2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 1828107 25416956 32296183 16511568 23661758 20195357 33961781 1827203 26186194 25609649 20102225
ATF2 RB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18638549 15618023
ATF2 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17258390 22542937 15546613
CDK2 EP300 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 33961781 26186194 10330164 23455922
FOS CLU â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10406964
RELA COL1A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10541434 11277268
COPS5 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11707426 18926707
COPS5 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18926707 17879958
COPS5 F2RL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16410250
JUN CXCL12 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21465475 17550983 21312239
EP300 MDM2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15154850 20234175 16713569 11070080 9809062 28196907 15013777
EP300 JUN â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 27956703 21268080 21937452 24069158 11689449 14630807 11980644 10327051 12437352 12471036 24636898
EP300 PPARG â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11500849 17468099 10944516 14701856 11287611 19596656 32603375 11877444 12040021 10075656 30595551 22787115 12479814
YY1 EP300 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22951020
MDM2 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9809062 11070080 16713569
EP300 ARNT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12573436 10999956
EP300 HDAC6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15102857 19344692
AR HMOX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11965035 20610535
NFKB1 HMOX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19752329 8016102
FLI1 HMOX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16310515 10022513
SPI1 MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 22075620 10727414
MAPK1 GATA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11585926
MAPK1 MARCKS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9867858 30225354
MAPK1 ALOX5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12670876 12205041
RELA MAPK14 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
MAPK14 F3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 23195225
MAP2K3 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8226933
MAPK3 ALOX5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12670876 12205041
AR MDM2 â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
AKT1 MDM2 â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
HIF1A MDM2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12606552 10640274 25447306 15880652 19696166 25535359 17234751 15385570
SMAD4 SKIL â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 10531062 12764135 15761153 17469184 25609649 33961781 15231748 25059663
AR SNAI2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20610535 16541421
LEF1 SNAI2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20128911 16179074
SNAI2 VDR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18485278 20138990 19502595
AR SUMO1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24119295 21796528 17932034
PPARG TNF â—¼   DOWN_REGULATES ✅ - 3.0 0.9 ACSN 10432118 17681149 23390297
NR3C1 TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15956716 15289446 16557033
YBX1 SMAD4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12917425 12446674 16278212
YBX1 AGT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11829142
YBX1 COL1A2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12446674 12917425 16278212
YY1 ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19435870 18218085 15870067
YY1 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9238849 21852380
RELA COL1A2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10201951
NFKB1 COL1A2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10201951
JUN IL10 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15699140 25567680 28100679
AHR IL10 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20676095 20676092 24315995
VDR IL10 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20691220
RELA PIN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19458071 19668231 16950761
SFTPA1 SFTPA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10781424 11087951 1986781
VIM TSC22D1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
MET HGF â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 17804794 18593464 15167892 1846706 28628118 1655405 19433454 20624990 18495663 16537482 22897854 28205554 17981115 8380735
SPI1 HGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22472882 9315634 9223667
AKT1 SMAD4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16362038 23397142
SMAD1 SMAD4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9111321 17183365 16189514 32296183 31467278 12167862 14701756 12874272 28468752 15761153 24412244 10531362 15231748 11700304 11779505 26555259 9436979 21454478
SMAD4 FN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19516008 15525600 17452626
SMAD4 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12374795 10022869
SMAD4 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12226080 16713569
PDPK1 MAP3K7 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 17496917 15125833 16056267
PDPK1 TAB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 17496917 15125833 16056267
TAB1 TAB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 14670075 14743216 10882101 17626013 21988832 18021073 19393267 27880917 19675569 12242293 16845370 32410369 33961781 25260751 21903422
SERPINE1 PLAU â—¼   DOWN_REGULATES ✅ - 3.0 0.9 ACSN 11021826 20027185 25502501
NFKB1 PLAU â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11689575 17407600 20352621
AR PLAU â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11676474 20610535 11745419
PLG PLAU â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 2521625 2935528 1829461
PLAU PLG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 3920216 2829380 4226004
USF1 IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 8900159 21050451
TGFB1 SMURF2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15496141 11163210 11278251
FOXP3 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 27861999 20554955 19797626
AR CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17617741 20610535 22040886
JUN NR0B2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15292277 12842887 19322021
JUN IL17A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22983707 21600798 23125217
JUN TIMP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9182717 23078099 18289921
JUN SFTPB â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10409233 21148742 11368910
JUN IL11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12929935 15546613 9488674
JUN NR3C1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16713569 7823959 8733011
NR3C1 RELA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12734399 9261164 9442377
RELA EGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15964798 21912613 23383347
RELA FOSB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20018891
RELA FST â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18226221
RELA MET â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19530226 20186924
RELA IL18 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10227974 17399992 15963597
RELA TNFRSF11B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18226221
RELA CCR5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19469019 9840284 12745546
RELA AGT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10628750 8833654 8613256
RELA WT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9572484 11243407
RELA TNC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20723226 9154819
RELA AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16713569 8798655
SMAD1 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23071089 12589053 16580992
HIF1A PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18461556 19490906 11879638
NR0B2 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 24038081 16803864 11696534
PPARG FOS â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10678274 23657115 18059282
NR3C1 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 15531761
PPARG NR3C1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 15531761
NFKB1 IL18 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10227974 17399992 15963597
IRF8 IL18 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10438937 15850451 10975835
SPI1 IL4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19592658 11150515 21957289
SPI1 IL1RN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20032313 12423202 9727052
SPI1 NR3C1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16263717
NR0B2 IL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10458769 11021818 15170389
CREBBP NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12789342 16835236
FOS IL4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7665092 10772943 9133600
NFKB1 HIF1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18498249 17898080
HIF1A TGFB3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10831118 16611863
HIF1A IGFBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9707622 10102273 18056423
HIF1A SLC2A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15059920 7493931 9525945
PAK2 CDC42 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 32296183 25416956 9535855 17353931 20696164 10320322 20936779 9822598 16204230 32707033 31871319 21311754
PDPK1 AKT1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 9368760 11825911 14500673 10698680 31467278 12149249 27563096 11313365 11278835 22569334 26264872 10226025 32876514 26256536 21775285 11438723 11445557 23397142
SERPINE1 PLG â—¼   DOWN_REGULATES ✅ - 3.0 0.9 ACSN 11021826 20027185 25502501
NR0B2 SERPINE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19643931 19887897 17074765
NFKB1 SERPINE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12675842 11757833 15631825
NR3C1 SERPINE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16423881 12902338 10518526
FOS SERPINE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8917435 11223948 12390531
AR PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18386814 16317058
AR IGFBP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20610535 23859805
FLI1 IGFBP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21531709 15282325
NR0B2 FOS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19509248 12571228 9452499
FOS GJA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8606973 17895291 12064606
NFKB1 IL1RN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20032313 12423202
NFKB1 AGT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10628750 8613256
NFKB1 WT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9572484 11243407
NFKB1 CDK4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24296733 18425349
NFKB1 FN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22223884 10649441 10867646
USF1 CDK4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15208653
SMAD1 TNFRSF11B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11139569 14672939
NKX2-1 ADCYAP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19285000 17464199 12122016
GATA4 ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19276186
ERBB2 SHC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16273093 16729043
LEF1 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16741972 16474850 19351848
AR NR3C1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24315100 15219414 20610535
AR MET â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20610535 20946682 17283128
RPS6KB1 HSPB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19593530
MAP3K11 MAP2K3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 9003778
NR3C1 IGFBP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23161582 9369450 18483179
EPAS1 ARNT â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 23434853 15192019 16181639 9079689 19845609 23275444 33591636 26160453 19129502 32461361 14668441 24981860 11018023 23796364
FOSB IL11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21931225 20927330 19665600
VDR ALOX5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19837082
NKX2-1 SFTPA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12040027
FOS ATF2 â—¼   PHYSICAL_INTERACTION ✅ 0.91 0.91 mint 25609649
MAPK1 MBP â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
EP300 JUN â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
ATF2 MAPK8 â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
HIF1A HDAC4 â—¼   PROTEIN_INTERACTION 0.92 0.92 HIPPIE 15280364 19071119 21148070 30867818 16951198
EP300 RELA â—¼   PHYSICAL_INTERACTION 922.0 0.92 STRING 36370105
CREBBP RELA â—¼   PHYSICAL_INTERACTION 924.0 0.92 STRING 36370105
MAP2K3 MAPK14 â—¼   PHYSICAL_INTERACTION 928.0 0.92 STRING 36370105
SUMO1 JUN â—¼   PROTEIN_INTERACTION 0.93 0.93 HIPPIE 10788439 15469925 11867732
CDK2 RB1 â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
AKT1 PDPK1 â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
CDK4 RB1 â—¼   PHOSPHORYLATION ✅ - 0.93 0.93 Signor 9139732
FST INHBA â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
ATF2 MAPK14 â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
SUMO1 HIF1A â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 20026589 15876874 24434214 20661221 15465032 17938407
SMAD4 SMAD1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 17183365 5219486
JUN FOSB â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 29020630 33961781 25609649
SMAD4 SMAD9 â—¼   PHYSICAL_INTERACTION 950.0 0.95 STRING 36370105
HIF1A EP300 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 17382325 5219810
AKT1 MDM2 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 32450252 25241761 18332867 12145204 19166854 15527798 20856200 11715018 23397142 11504915 11923280 21930127
SMAD1 SMAD4 â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
ITCH TXNIP â—¼   PHYSICAL_INTERACTION 964.0 0.96 STRING 36370105
MAPK14 TAB1 â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
CREBBP SUMO1 â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
CDC42 PAK2 â—¼   PHYSICAL_INTERACTION 968.0 0.96 STRING 36370105
HIF1A EP300 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 15280364 19589782 16543236 11823643 22807441 19666581 16189267 18047470 15342390 12042299 19680224 22735262 23448368 26135796 23618863 14691445 19696166 11959990 27320910 16847340 24821806 22789427 17906695 8917528 20620956 20000859 15261140 16081065 12778114 22219185 15154850 25192544 22075993 19071119 22908229 19940151 21187066 24421387 23880760 11940656 23966271 26826385 26944191 12588875 23746844 11063749 27808477 19074848 20603618 15155277 18268343 20829524 21148070 12914934 17502379 22684029 17382325 26751287
HIF1A ARNT â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 17916562 9159130 24434214 20049704 9704006 11606485 27684187 19168635 11829741 23458834 19845609 16861921 9079689 19251694 11593383 27320910 15850782 15833858 20562859 14764593 12391259 26496610 17197389 8663540 15479785 26160453 14668441 24056783 11025203 28205554 23796364 23363003 20458141 23086815 17213817 21620138 15615775 7836384 15319539 12393189 11782478 15347669 20932347 21512126 10085255 21435239 26350169 15031145 20603618 28628118 20699359 10671489 33961781 34592152 16520375 12810720 16954218 18024476
CREBBP PPARG â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
PLAU SERPINE1 â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
SKIL SMAD4 â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
AHR ARNT â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
ATF2 JUN â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
FOS JUN â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
ARNT AHR â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 8065341 28514442 11768231 9704006 11259609 7488247 19380484 20006590 22138065 11025203 10617682 23477502 9887096 31675361 12024042 12139968 11551916 17392787 18096572 8384309 10619402 7628454 19390533 26350169 8631989 8621524 10671489 33961781 10395741 8619634
CREBBP HIF1A â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CDK4 RB1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
MAP3K7 TAB2 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
ARNT EPAS1 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
EP300 HIF1A â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
JUN MAPK8 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ATF2 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 10366004 10327051 8530413 12052888 15068801 12751796 9502786 9141200 9252389 11238729 12903123 19255142 11736649 16511568 9819389
ATF2 IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18641343 12836278 20006311 20304822
ATF2 TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 20068037 15356147 11490006 10748079 12509451 10688670 10318823 10913190 10954918 16888805 15546613 20018859 9826775 8816436 8552071
ATF2 FN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21479385 8335091 10471826 8703044 9151819
ATF2 PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11901151 17591797 11278336 12057991 16007171
MAPK1 ATF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 10777545 17081983 21098032 9430721 12110590 20068231 19690332 15304344 19413330 10878576 15192015 7737129 18669648 19647037
MAPK3 ATF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 10777545 12110590 20068231 15304344 15192015 19647037
MAPK14 ATF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 104.0 1.0 Omnipath 17081983 18767875 21098032 20506250 26359454 19690332 11060298 19413330 12788955 10085140 22037767 11566021 17079470 19647037 10581204 10777545 7535770 23331499 7839144 19324872 21071413 21614932 20068231 16393692 15304344 17570479 17380123 18988627 7737130 18669648 15187187 9305639 7737129 15140942 602896 11896587 17548358 12110590 7824938 8663524 33893075 12024021 11078583 11971971 9707433 17258390 10821277 19651622 19436832 11259586 27726305 11781825 9430721 27142525 10909971 12118074 15569672 15212693 9753474 11274345 10903740 26987986
RB1 ATF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 1641004 11566021
MAPK8 ATF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 64.0 1.0 Omnipath 17145710 11279118 17081983 20506250 12958075 9162092 19255142 8654373 20028971 15105425 17626013 12788955 11566021 15550563 10777545 23331499 7535770 15068801 21071413 17875713 9317150 16393692 15304344 18988627 7737130 26538579 21444723 602896 11896587 12110590 7824938 11274345 12874243 11971971 9399639 19436832 16533805 9670022 9029150 11865055 9207092 12804775 7737129 15212693 9405416
SMAD4 ATF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10085140
ATF2 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 25609649 20102225 15546613 2320002 10327051 1827203 9445037 26496610 20195357 16511568 20511396 10207054 8027667 23661758 31515488 18641343 1828107
RB1 CDK2 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 10323868 10375532 16582612 12730199
CDK2 RB1 â—¼   ENZYMATIC_REACTION ✅ 27.0 1.0 ACSN 12086603 14536078 14988723 15136767 15147722 15175241 15279786 15798197 16713580 16805667 17102137 17116885 17296725 17303408 17384638 17582221 17660363 18469862 18590585 18636226 18995830 19282663 19342888 19622404 19793801 20051983 7575488
MAPK1 CDK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10962581 12359725
AKT1 CDK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18354084 29665367
CDK2 GRK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 11120772 21852138 20080565 33806062
CDK2 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 77.0 1.0 Omnipath 26581405 9315635 17303408 18692063 23437375 19413330 20871633 26148348 28806746 15279786 16326706 8626527 21902831 14627988 7575488 9190208 21697511 9139732 20068231 17570479 16189514 12006580 11420722 18669648 15811853 18590585 27507850 17380128 23160093 19638577 1756735 20418918 19262748 17660363 11777937 10499802 19651622 20058876 15173007 22263797 10207050 8756624 10542199 19664994 24466208
CDK2 RUNX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 25914884 17570479 16046550 17015473
COPS5 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 11818334 27060206 16713569 17583730 14993265 1818334 24078030
COPS5 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 25609649 20093369 18926707 10766246 16713569 8837781
HIF1A CXCL12 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 10804084 16110315 16127144 17533374 20427344 20535745 20855962 21051947 21765015 22006996 22850421 22988108 24006507 25043024 25103413 25732824
HGF CXCL12 â—¼   ENZYMATIC_REACTION ✅ 14.0 1.0 ACSN 12649206 15059978 16212809 17145802 18633355 19631971 22763439 23402812 23667593 26366398 26819959 27474009 28475121 9242465
IFNG EP300 â—¼   ENZYMATIC_REACTION ✅ 31.0 1.0 ACSN 10485906 11489965 11579131 11777960 11870632 11964313 12413632 12818165 14607900 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 1825141 18272812 19833085 20038811 20819927 21149606 21411734 24658051 26755705 2965306 6425450 9834059 9864217
EP300 PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12057991 17395887 17237818 12471036
AKT1 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 17623675 18182168 16926151 20333651 19158375 17964260 17570479 11116148 25904863 21901101 23275565 16024795
MAPK1 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17623675 24530506
EP300 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 19608861 25400040 11567019 12419806 17617622 11533489 20333651 12456660 15152190 16846590 9096323 20064247 16382138 16713569 15171256 16135789
EP300 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11971970 10779504 24480624 17011549 16713569
EP300 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 9843571 19419955 22033265 9679056 21269274
EP300 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12419246 14500836 10673036 22298955
EP300 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 75.0 1.0 Omnipath 24821806 12573436 17145710 16847340 12588875 19589782 11940656 25192544 11959990 18519678 23448368 22219185 11823643 12042299 15342390 23746844 19071119 19680224 27808477 15154850 19696166 8917528 17906695 18268343 22735262 21148070 15261140 19940151 23880760 22807441 35430356 14691445 12914934 20000859 12778114 26751287 16081065 22789427 16543236 24421387 17382325 17502379 22684029 21187066 19074848 23618863 23966271 20603618
EP300 YY1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 11486036 7758944 18542060 9199306 17510411
HMOX1 TNF â—¼   DOWN_REGULATES ✅ - 10.0 1.0 ACSN 11399519 11875494 15644117 16127449 17260466 17689680 22461508 23390297 6357187 8871614
JUN HMOX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8774698 24755082 8872603 20486760 20833713 18689604
HIF1A HMOX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 11592948 19828020 20819234 17389506 10600883 11356853 15805230 18799519 17122584 17996129 20526373 15050899 20833713 14970910 19254160
USF1 HMOX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 7969144 8760880 18331200 15242350 2318208 2722866
AKT1 HMOX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15581622
IFNG ICAM1 â—¼   ENZYMATIC_REACTION ✅ 31.0 1.0 ACSN 10485906 11489965 11579131 11777960 11870632 11964313 12413632 12818165 14607900 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 1825141 18272812 19833085 20038811 20819927 21149606 21411734 24658051 26755705 2965306 6425450 9834059 9864217
IL18 ICAM1 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 10679398 11592085 14504095 14662834 15099563 15802534 26885855 27048821 27066895 9469432
IL10 ICAM1 â—¼   DOWN_REGULATES ✅ - 31.0 1.0 ACSN 10433356 10542212 10623821 10925299 11207245 11438547 11875494 12193690 12811837 12818165 14607900 15282297 15579430 15749903 15833879 16200688 16424049 16713974 17404308 17485448 20184663 20435894 20547845 21115385 21191065 21220452 23124025 23508573 24378531 26755705 9834059
RELA ICAM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 55.0 1.0 Omnipath 10926553 7822333 9192770 9831247 7957928 15996193 22337883 19074768 16778171 9188493 16317091 17121934 18928584 15843586 22001597 9056676 18285351 16385502 10946302 15946255 20103608 10738944 15800027 22708120 23238746 22901690 9888295 11877286 7659084 17855547 10553096 10092659 9733827 11401521 11463837 9916895 20173029 10837365 16455661 19351910 20823682 12691701 16105834 12490396 17537731 22345292 10228026 16453001 19278584
JUN ICAM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11356008 12832416 9218873 20459645
NFKB1 ICAM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 38.0 1.0 Omnipath 10926553 15480988 9192770 7957928 11198351 19074768 9188493 16317091 17121934 18928584 15843586 22001597 9056676 18285351 16385502 10946302 20103608 10738944 15800027 22708120 9888295 11877286 17855547 10553096 10092659 9733827 11401521 11463837 9916895 20173029 10837365 12691701 16105834 12490396 16453001
MAPK14 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 15187187 21675959 18039929 12738796 11157753 22521293 17255949 11238443 11274345 12697810
MAPK1 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12975377 23602568 16424009 19058874 23397142 21707490
MAPK1 NR3C1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 12351702 18669648 9199329
MAPK1 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 8072547 11313929 15378002 12531896 12853483 23720779 9662434 1496019 17570479 1922387 11278277 11739718 16023596 20086174 25557171 7737130 26755651 8224842 14676207 17920329 25201974 9022811 22327296 18650425 8137421 18443042 12881422 18572021 17001009 33767435 7744008 23616010 26745678 14617628 11432833 16819515 22606284 12040039
MAPK1 GJA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 22028470 9535909 19664994 9535905 12637502 15605363 8631994 17570479
MAPK1 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 25409419 11733495 16574647 9099735 9030579 15507114 26670611 17570479 17998334 18596912
MAPK1 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12801888
MAPK1 RPS6KB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 43.0 1.0 Omnipath 12054624 15547943 20080742 14967450 12040186 15173823 12697810 11940578 7545671 16227978 21035469 12738796 16039586 9722592 17255949 15774499 15187187 19541618 19091303 19565474 17052211 19085255 11279232 9271440 18039929 18775330 11705993 10601235 12792650 11431469
MAPK1 RUNX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16046550 17015473
MAPK1 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 16954218 10551817 18519666 18687685 26784107
MAPK1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 18511414 9725910 10318905
MAPK1 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 37.0 1.0 Omnipath 15001544 17081983 18949383 16123357 27014871 16914728 17360977 16099428 30401435 16131083 17640984 12510059 15613682 21850561 14579029 20594869 8626671 9395471 19651622 15576463 22289259 14769130 16020478 17242212
MAPK1 MBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 11258664 17255944 12760422 10371216 12944901 1939237 9792705 16401070 15380617
MAPK1 FOS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 49.0 1.0 Omnipath 12134156 20506250 15547943 8248197 7816602 15084594 12697810 8226933 20068231 18452278 12738796 16393692 17255949 17439715 15187187 19541618 23109003 19565474 17722974 17052211 7588633 8545107 16055710 8388392 18039929 12972619 18775330 21098038 9604935 11274345
MAPK1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15073167 16888388 16691505
MAPK1 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 17289590 19914168 9335504 19914161
MAP3K7 MAPK14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12589052 17965022 15692051 17947236
MAP2K3 MAPK14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 91.0 1.0 Omnipath 12589052 11279118 17081983 20213747 7914033 18767875 17322306 23602568 8622669 18855897 19690332 23904011 9162092 11426938 15592455 18083107 7997261 12384504 15735649 18291705 23331499 17389395 7535770 19534553 7839144 21071413 16083285 21614932 20068231 12738796 16189514 17255949 18669648 16153436 14970210 26186194 16407200 11242034 18691976 18088087 11304531 15972258 10781613 17192257 18586681 10734320 19651622 7592586 16157584 19369195 9582275 15674326 9528766 7693711 9841871 12758252 11309380 7750576 15212693 15659558 11274345 15735648
GRK2 MAPK14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 17055984
MAPK14 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 15187187 21675959 18039929 12738796 23397142 11238443 11274345 12697810
MAPK14 EPHB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12738796 18039929 11274345 15187187
MAPK14 TAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 28.0 1.0 Omnipath 24443058 22216226 33204339 19393267 25241761 11847341 16648477 12429732 14592977 22307082 17570479 26391660 17126905 21900206
MAPK14 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 11439341 17599043 9190208 15355984 17380128 22279936 27642049 33419772 1756735 17996702 17570479 22895174 20871633 20223825 33219128
MAPK14 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 30644418 24424504 21820033 16282370
MAPK14 USF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 16622840 11532965 21873430 19389701
MAPK14 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12842894 15128824 15485852 10521409 15489227 15849198 15212693 12767944
MAPK14 NR3C1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 25847991 12351702 28582465 31974640 20047289 22911818 19841061 12000743 15817653 20660302 17570479 22401993 17440046 17185395 24024586 19812390
MAPK14 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12475989 17689131 17570479 25483191
MAPK3 FOS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 17018293 12134156 20506250 15547943 7816602 15084594 12697810 8226933 12738796 16393692 17255949 17439715 15187187 19541618 23109003 19565474 17722974 17052211 7588633 8545107 16055710 8388392 18039929 12972619 18775330 26725323 21098038 9604935 11274345
MAPK3 GJA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 22.0 1.0 Omnipath 9535909 19664994 9535905 12637502 15605363 8631994 17570479
MAPK3 GRK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 19651622 18767875 23772028 18088087 10574913 10727525
MAPK3 MBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 10339476 16401070 1939237 1699809
MAPK3 RPS6KB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 15547943 20080742 14967450 12040186 15173823 12697810 11940578 16227978 12738796 16039586 9722592 17255949 15774499 15187187 19541618 19091303 19565474 17052211 11279232 9271440 18039929 18775330 10601235 12792650 11431469
MAPK3 HDAC6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 24089523
MAPK3 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10551817 18519666 24099156
MAPK3 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 15001544 16131083 8626671 14769130 9335553 15613682 12510059 15212693 9395471 14579029
MAPK3 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 10197981 9335504
MAPK3 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 28115363 12801888
MAPK3 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18596912 11733495
MAPK3 NR3C1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12351702 17440046 9199329 20047289
SNAI2 MDM2 â—¼   PHYSICAL_INTERACTION 51.0 1.0 ACSN 10721693 11283614 11715018 11779693 11923280 12545156 12668723 14761977 15024084 15140942 15151915 15155580 15169778 15465827 15574337 15876864 16232121 17055429 17110379 17158541 17508028 17550342 17823410 19448627 19459846 20027199 20066118 20182602 20457558 20506250 20679392 20713526 20818389 21234400 21336307 21340684 21483453 21518799 21733352 21764762 2191300 21919891 22102694 22370643 22754780 22796940 23140366 23869868 6396087 9450543 9618481
SNAI2 MDM2 â—¼   SHARES_COMPLEX 51.0 1.0 ACSN 10721693 11283614 11715018 11779693 11923280 12545156 12668723 14761977 15024084 15140942 15151915 15155580 15169778 15465827 15574337 15876864 16232121 17055429 17110379 17158541 17508028 17550342 17823410 19448627 19459846 20027199 20066118 20182602 20457558 20506250 20679392 20713526 20818389 21234400 21336307 21340684 21483453 21518799 21733352 21764762 2191300 21919891 22102694 22370643 22754780 22796940 23140366 23869868 6396087 9450543 9618481
AKT1 MDM2 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11154281 11715018 11923280 15169778 17680028 20214616 20398329
SNAI2 MDM2 â—¼   DOWN_REGULATES ✅ - 51.0 1.0 ACSN 10721693 11283614 11715018 11779693 11923280 12545156 12668723 14761977 15024084 15140942 15151915 15155580 15169778 15465827 15574337 15876864 16232121 17055429 17110379 17158541 17508028 17550342 17823410 19448627 19459846 20027199 20066118 20182602 20457558 20506250 20679392 20713526 20818389 21234400 21336307 21340684 21483453 21518799 21733352 21764762 2191300 21919891 22102694 22370643 22754780 22796940 23140366 23869868 6396087 9450543 9618481
AKT1 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 60.0 1.0 Omnipath 11756412 11923280 20856200 20452955 20398329 18332867 19664995 10217147 11154281 19216069 20214616 11463845 19166854 15527798 9829964 17570479 16680151 17646672 12145204 15169778 15140942 25241761 11715018 25209720 17680028 21930127 11504915 29311840 15574337 23397142
MDM2 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 15880652 25535359 12606552 25447306 17234751 19696166 10640274
MDM2 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 16374512 21990374 7791904 28615518 33185004 20871633 10078201
MDM2 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 17974989 26411689 27835608 26973243 15640443 12145204
PIAS4 LEF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11731474
PIAS4 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 16713569 14981544 11439351
PIAS4 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 12815042 12740389 12904571
AXIN1 RNF111 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16601693 23331499 14657019
RNF111 SKIL â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17591695 17510063
SMURF2 SKIL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11389444 23331499 15221015
SKIL SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 12764135 25609649 23331499 25059663 15761153 10531062 17510063 12793438 17469184 15231748
SMAD4 SNAI2 â—¼   UP_REGULATES ✅ + 31.0 1.0 ACSN 11074002 11279127 11792802 12490555 12702545 12809600 14623871 15265520 16510505 16617148 16713975 16831886 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18832382 19208835 19412634 20731704 21199805 21317430 21614932 21883379 22006115 22406545 22945800 9389648
SNAI2 L1CAM â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20799950 21109948
LEF1 SNAI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 20731704 19751508 7542250 11967263 22406545 17093497 21317430 11955436 22270359 18832382 12051714 8666229 12490555 16510505 16940750 21199805 17550342 16831886 14623871
SUMO1 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 14514699 23331499 21071413 12813045 12740389
SUMO1 NR3C1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16189514 12193561 12144530
HIF1A TNF â—¼   ENZYMATIC_REACTION ✅ 28.0 1.0 ACSN 10754326 10804084 10952726 11875494 12907458 14660645 15465827 15644117 16110315 16127144 16878026 17404308 17485448 17533374 20427344 20535745 20855962 21051947 21765015 22006996 22850421 22988108 23390297 24006507 25043024 25103413 25732824 7594497
TNF TAB2 â—¼   ENZYMATIC_REACTION ✅ 57.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
TNF MAP3K7 â—¼   ENZYMATIC_REACTION ✅ 57.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
TNF FOXP3 â—¼   DOWN_REGULATES ✅ - 24.0 1.0 ACSN 11112697 12646658 1431106 14607933 14625680 15099563 15699106 17916596 18633355 19411070 20038811 20184663 21133840 21411734 21826665 22955274 23170255 23430059 23510023 23567181 23769623 24092389 26201938 8910423
PPARG TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 20376096 11009565 14646597 20473515 11124825 17532302 17464333 19031802 14656714
SPI1 TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 18802049 10748079 19646961 8998076 18408586 18357389 25567680
NFKB1 TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 74.0 1.0 Omnipath 17513725 12058956 24337575 12657243 17704137 12471036 17707233 7624137 11259437 12686724 16433741 26114754 20237317 7876168 16707469 12117498 14976218 10485496 15465827 8622636 15812247 21138578 18990758 10748079 15013838 15749903 16916598 17646159 10754326 16040075 10837498 18285351 11675405 11739517 15743782 20066113 20617556 17085785 8530146 8805669 10919279 14960579 1740105 10963848 16055086 9742085 17292554 10553096 11312646 15543947 17442180 16285952 10079106 11297551 10551799 10201927 12907458 8679226 9281604 22782967 8219230 11749970 9916895 11094063 11490006 7895918 1618817 16483936 18057724 20722069 16569682 9452482 17407192 17082635
AHR TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11470802 17588258 25690886 19703987 15627257 20181658
HIF1A TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 21386799 17451682 15604270 17548584 17884817 15925386 22320863 23359428 23085511 19766100 16007254 12479793
JUN TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 12759366 11087751 7935377 21059644 16881863 24548427 12509451 9826775 10318823 8998076 18408586 15546613 20164416 7896795 9211933 10952728 9566900 23583459 10748079 24009130 10954918 10754326 9813054 10837498 9988757 11739517 16365438 19285436 16199883 8816436 10551799 8552071 9160673 11490006 21098092 16483936 10688670 10913190 16888805 9030359 25567680 9760243
FOS TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 19285436 2506186 16834785 22322974 10837498 12057991 9030359 25567680 19026727
RELA TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 136.0 1.0 Omnipath 26596471 17707233 20817730 12686724 27075886 21765477 21537341 19530226 17390058 18077329 15064230 20617556 8805669 17351769 23335080 21573233 17292554 16285952 9916895 11749970 7895918 17496784 12628924 23857586 12657243 15857826 12471036 11259437 16433741 9831247 20237317 15465827 26023919 22661093 10748079 15013838 17350185 10754326 15470505 11827962 20139176 26408955 22901690 18772140 21108432 22742857 23195252 18362169 24012417 11312646 17442180 9281604 10079106 11297551 15081318 22718766 24908318 8219230 26004152 11094063 11490006 9916692 16483936 18057724 16569682 22138107 18467438 20547752 22723832 19846753 17407192 20221401 19854828 20534538 7876168 16707469 12117498 20544543 23178569 15812247 21138578 12610112 25888873 16916598 16040075 28039105 14749357 20066113 19285436 25161822 22388040 14960579 20195282 16199883 15543947 23971673 10551799 11290773 22798670 22021035 20722069 20221720 27338466 19385047 12058956 26997758 25690886 7624137 20686703 26114754 14976218 10485496 17607667 8622636 11007957 18285351 10837498 11739517 18719026 17268554 17085785 17142966 10963848 9742085 23042817 27534992 10553096 26516703 20696864 10201927 16850160 8679226 21098092 20097764 9129150 17082635
TNF RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 39.0 1.0 Omnipath 15192014 27329558 22240205 15833743 19351843 28187781 15841081 28107185 28373828 26999213 24386331 24957606 26179215 21572963 18258304 28317833 29441018 10722927 19596989 28423685 12881425 25118327 24036851 28089769 21904602 24141032 10938077 30201812 20691659 24166907 19789307 19393267 22768286 26310932 19411070 23789107 28790310 29708974 20507904
TNF IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 22328823 22869320 19808894 12110133 11160134 12409308 22266116 21478880 11684411 25352752 24966659 29425748 16754954 25355439 22823902 18443205 24648009 26976796 25645159 23592917
AKT1 YBX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 17081983 32028981 33911076 26318844 33151228 20844753 27591085 17704806 21423216 19036157 31906126 15806160 24335958 34272387 33379356 19651622 31387591 16354698 19664994
NFKB1 YY1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 17438126 21725609 23178297 23572150
RB1 YY1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12588874 11118439
SMAD4 COL1A2 â—¼   UP_REGULATES ✅ + 34.0 1.0 ACSN 10964912 11007770 11013220 11074002 11114293 11279127 11283614 11792802 12545156 12702545 12809600 15001984 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23869868 8515656 9389648 9618481
SMAD4 COL1A2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10797313 11007770 10918613 16319104 9886263 19641518 22048127
SMAD4 COL1A2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11074002 9389648 11114293 11013220
FOS IL10 â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 15067049 15749884 16243976 16327802 16393692 16394015 16413922 16713974 17404308 17485448 19667062 20547845 21372296 21385848 22634314 23390297 23430059 9064320
CSF1 IL10 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 11306493 15749884 16713974 17404308 20547845 24669294
IFNG IL10 â—¼   ENZYMATIC_REACTION ✅ 31.0 1.0 ACSN 10485906 11489965 11579131 11777960 11870632 11964313 12413632 12818165 14607900 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 1825141 18272812 19833085 20038811 20819927 21149606 21411734 24658051 26755705 2965306 6425450 9834059 9864217
FOXP3 IL10 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 20554955 20573297 19775525 24315995 18374871
NFKB1 IL10 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15465827 9310124 19124729 19766270 16835236
RELA IL10 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 18760861 9310124 19124729 19122653 18077329 22070873 27324129
SPI1 IL10 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 20072143 19592658 18843277 12424622 25567680
AXIN1 PIN1 â—¼   PHYSICAL_INTERACTION 22.0 1.0 ACSN 11274345 11283614 16713974 16940750 17558397 17873522 19131971 19366350 19751508 19836308 20027199 20237412 20551172 20581311 20713526 21406394 2191300 22067385 22270359 23732914 25002027 26885856
AXIN1 PIN1 â—¼   SHARES_COMPLEX 22.0 1.0 ACSN 11274345 11283614 16713974 16940750 17558397 17873522 19131971 19366350 19751508 19836308 20027199 20237412 20551172 20581311 20713526 21406394 2191300 22067385 22270359 23732914 25002027 26885856
MAP3K11 PIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 27618008 28426725 34052323 22566623 25519816
PIN1 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16713569 11432833
TLR2 SFTPA2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 16834340 12817025 16213021 11724772
JUN VIM â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 7986748 14654785 2922288 16831196
AKT1 VIM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20856200
PAK2 VIM â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 40.0 1.0 Omnipath 11895474 19007248 17081983 20166139 18767875 12458200 12761892 19664995 18578522 11420699 20068231 15713670 18669648 14722118 2500966 17287340 19651622 20058876 19691289 18212344
HIF1A VEGFA â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10804084 16110315 16127144 17533374 20427344 20535745 20855962 21051947 21372296 21765015 22006996 22461508 22850421 22988108 23390297 24006507 25043024 25103413 25732824
NFKB1 VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 18184402 17673602 16684540 15517885 12160329 15856023 18056465 20538607 17407600 20103608
JUN VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 9256279 11204570 11353786 23274526 11678207 17341624 20015448 8910439 16328781 11731421 15039660 19553068 20432243 7887961 12163680 10885623 11281649 14602779 18294451 15277220
RELA VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 18184402 17673602 16684540 15517885 12160329 15856023 18056465 20538607 17407600 20103608
SMAD4 VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 23184087 10944227 20797318 12622415 24625091 20631490 18505344
AR VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16007189 23369005 18768969 18612129 15003169
HIF1A VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 186.0 1.0 Omnipath 20303950 17085645 22609851 12697836 17557905 15140752 17431122 17486380 11866451 20453883 8756616 18027712 10702253 11678207 19046997 19491109 20127031 20307196 15315159 11359907 18233956 12032158 19502554 9178256 15956714 23060442 11350893 15930297 15207747 19074414 20660740 20489156 17089387 15735682 16506055 9746763 21793044 20436213 22789427 21814878 17053163 18835464 18072084 15983061 11749701 20875806 18432192 18471962 15039660 16750526 17322369 16052307 12433987 21447827 16682453 16971129 21258402 20027628 12542982 17272396 20574527 14712484 16865543 17916562 19664474 23354733 18060642 12570801 9235919 22903062 18563715 12154035 12612059 20599538 18572865 21187066 10837481 16596228 12963476 19828020 15169887 15156561 20232316 16969516 15111179 15342781 15475194 9398602 11001829 11191064 10882714 8387214 15191799 12820439 17413038 19111391 16854277 12509854 23404377 16900513 24347168 18021292 17947829 22771629 18295594 15774498 12205045 17498666 11007955 14699103 21145972 16618748 18322419 16540671 20724477 16778202 9393757 11549290 17065555 15315937 18024476 21343542 15705785 10987301 22306343 23086815 16774940 19420388 15050899 19759417 18289162 10415537 15277220 16818499 16982770 24464787 19238077 23028984 11056102 15838297 16301840 18578647 18702304 19020709 19564336 17461470 16515634 20043814 15806152 19336759 22750006 23185615 17470361 15746177 17889387 18339855 15890092 15663958 17704802 10477681 12052835 15382039 11707426 12855680 12023962 20432243 10611972 19819950 9359410 10640274 12393646 16311927 21435239 16357173 21731766 16543242 17481912 20449875 14602779 17167225 11486006 18294451 22076197 17999410
EPAS1 VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 15156561 15192019 19010893 15191799 19080330 20061373 9113979 16900513 20574527 10531360 21057546 21145972 11350893 16778202 23213445 11301389 20807755 9746763 9665461 11751212 12750296 24062466 11912213 16920734 17322369
ARNT VEGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 15930297 18372249 17413038 21814878 7641334 22306343 19020709 23086815 16774940 8756616 10702253 22076197
ARNT VEGFA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 7539918 17987801 1823643 16716598 12829734 9159130 13130303 9746763 12080085 11566883 10403805 7768934 8943284 15451019 11528470 9278421 16887934
HIF1A VEGFA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 7768934 11528470 9278421 17987801 16716598 12080085 10403805 16887934 7539918 1823643 12829734 13130303 15451019 9746763 8943284 15369676 9159130 11901189 22952674 11566883
HGF MET â—¼   PHYSICAL_INTERACTION 16.0 1.0 ACSN 11290563 12649206 15059978 16212809 17145802 18633355 19631971 20303741 22763439 23402812 23667593 26366398 26819959 27474009 28475121 9242465
HGF MET â—¼   PROTEIN_INTERACTION 16.0 1.0 ACSN 11290563 12649206 15059978 16212809 17145802 18633355 19631971 20303741 22763439 23402812 23667593 26366398 26819959 27474009 28475121 9242465
PPARG HGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22472882 24569592 16291834 11292834
HGF FN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8780385 25241761 15717924
HGF MET â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 57.0 1.0 Omnipath 17145710 22897854 15167892 1655405 20624990 19433454 23331499 17804794 1846706 28475121 22001117 16537482 15218027 27147579 24362531 17667909 16397249 20178463 17981115 28534512 8380735 18495663 14685170
SMAD4 SPP1 â—¼   PHYSICAL_INTERACTION 47.0 1.0 ACSN 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 8515656 9312026 9389648 9618481 9670020
SMAD4 SPP1 â—¼   SHARES_COMPLEX 47.0 1.0 ACSN 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 8515656 9312026 9389648 9618481 9670020
SMAD4 NOX4 â—¼   ENZYMATIC_REACTION ✅ 14.0 1.0 ACSN 11074002 11279127 11792802 12702545 12809600 15265520 16179589 16713975 21042762 21614932 22331441 23784029 9389648 9670020
SMAD4 SPP1 â—¼   ENZYMATIC_REACTION ✅ 47.0 1.0 ACSN 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 8515656 9312026 9389648 9618481 9670020
SMAD4 TNC â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 8515656 9389648
SMAD4 IFNG â—¼   DOWN_REGULATES ✅ - 25.0 1.0 ACSN 10925299 11074002 11279127 11399519 11792802 11875494 12193690 12702545 12809600 15265520 15644117 16127449 16179589 16713975 17260466 17689680 18768831 21042762 21614932 22331441 23390297 6357187 8515656 8871614 9389648
SMAD4 TBX21 â—¼   DOWN_REGULATES ✅ - 25.0 1.0 ACSN 10925299 11074002 11279127 11399519 11792802 11875494 12193690 12702545 12809600 15265520 15644117 16127449 16179589 16713975 17260466 17689680 18768831 21042762 21614932 22331441 23390297 6357187 8515656 8871614 9389648
SMAD4 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21836474 21926264 16580992 12524424
SMAD4 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10964912 15647271 10843986 21968601
SMAD4 SERPINE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9792626 19752858 9765209 12551947 10636910 10092624 9606191
SMAD5 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 20957627 23331499 14534577 16516194 16189514 10531362 15231748
JUN SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10220381 9312063 9732876
SMAD1 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 34.0 1.0 Omnipath 17183365 9436979 24412244 11779505 31467278 21454478 10531362 15231748 12167862 23331499 21071413 11700304 12874272 16189514 18988627 20957627 9111321 15761153 32296183 26555259 14701756 14534577
SMAD9 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 20957627 25502805 10583507 31515488 16189514 15231748
SMAD4 LEF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 10890911 21071413 18988627
SMAD4 FOS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 9732876 10942775
TAB2 MAP3K7 â—¼   PHYSICAL_INTERACTION 25.0 1.0 ACSN 10391247 11280761 11460167 11477091 12620219 14633987 14660645 15082531 15125833 16603398 16799562 17301840 17363905 18264787 18641653 19161412 20164171 21041997 21133840 21232017 22941947 23681101 24403530 24699077 24958845
TAB2 MAP3K7 â—¼   SHARES_COMPLEX 25.0 1.0 ACSN 10391247 11280761 11460167 11477091 12620219 14633987 14660645 15082531 15125833 16603398 16799562 17301840 17363905 18264787 18641653 19161412 20164171 21041997 21133840 21232017 22941947 23681101 24403530 24699077 24958845
MAP3K7 MAP2K3 â—¼   ENZYMATIC_REACTION ✅ 25.0 1.0 ACSN 10391247 11280761 11460167 11477091 12620219 14633987 14660645 15082531 15125833 16603398 16799562 17301840 17363905 18264787 18641653 19161412 20164171 21041997 21133840 21232017 22941947 23681101 24403530 24699077 24958845
MAP3K7 FOXP3 â—¼   ENZYMATIC_REACTION ✅ 26.0 1.0 ACSN 10391247 11280761 11460167 12620219 14633987 14660645 15082531 15125833 15282297 16200688 16603398 16799562 17301840 17363905 18264787 18641653 19161412 20060931 20164171 21041997 21133840 21232017 22941947 24403530 24699077 24958845
SMAD6 MAP3K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11737269 10748100
TAB1 MAP3K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 88.0 1.0 Omnipath 17145710 16289117 18180283 10838074 24912525 23934659 10882101 19556242 11259596 19026643 14670075 17299140 23331499 22158122 12372426 21903422 17560374 21071413 23180781 19775907 14743216 17348859 20200282 26432169 18988627 10094049 8638164 11809792 10702308 25241761 19232515 14633987 18456659 10921914 20538596 15590691 16845370 27468689 12975377 12242293 17172402 22167179 12429732 12624112 12859960 16260783 11460167
TAB2 MAP3K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 112.0 1.0 Omnipath 17145710 11477091 17301840 18180283 10838074 24912525 16251197 10882101 19556242 15125833 19955178 31250519 36130827 17363905 17158449 11259596 19026643 24699077 14670075 18641653 24061540 24403530 23331499 22158122 12372426 21903422 27426733 21071413 23180781 14743216 18021073 21133840 20200282 26432169 21232017 18264787 20194509 10391247 18988627 22081109 8638164 16799562 11809792 19232515 12620219 14633987 19161412 20538596 22941947 23681101 20932475 15590691 12609980 16845370 27468689 12242293 11280761 15082531 26192618 14660645 24958845 17172402 15327770 25642820 22167179 20164171 16603398 17384642 11460167 21041997
MAP3K7 MAP2K3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17299140 21902831 23331499 8663074 12791976
MAP3K7 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15692051 17947236 11865055 17965022 17186025
MAP3K7 PRKAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16054096 16054095 15509864 19197243 17244528 18692468 15980064
TAB2 TAB1 â—¼   PHYSICAL_INTERACTION 16.0 1.0 ACSN 10391247 11274345 12620219 14660645 14704854 14960582 15082531 17127310 17884187 18264787 18762249 18855897 19020754 19136967 20194509 23070005
TAB2 TAB1 â—¼   SHARES_COMPLEX 16.0 1.0 ACSN 10391247 11274345 12620219 14660645 14704854 14960582 15082531 17127310 17884187 18264787 18762249 18855897 19020754 19136967 20194509 23070005
TAB2 MAP2K3 â—¼   ENZYMATIC_REACTION ✅ 25.0 1.0 ACSN 10391247 11280761 11460167 11477091 12620219 14633987 14660645 15082531 15125833 16603398 16799562 17301840 17363905 18264787 18641653 19161412 20164171 21041997 21133840 21232017 22941947 23681101 24403530 24699077 24958845
EGF PLAU â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 12094222 15003992 15175028 15466195 15958574 18423981 19631971 20430953 21098712 8101258
PLAU PLG â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 18633355 20027185 22470492 27216177
RELA PLAU â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11689575 20352621 18226221 19165610 22797919 20018891 10467400 9914486 17407600
SERPINE1 PLAU â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 22449964 2544876 2161846 21199867 3090045 9184208
TBX21 IFNG â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 10761931 12055627 12802010 14614857 15084276 16410834 17440449 18768831 26885856
IFNG RELA â—¼   ENZYMATIC_REACTION ✅ 48.0 1.0 ACSN 10485906 10679398 11489965 11579131 11777960 11870632 11964313 12133954 12413632 12759422 12818165 14607900 14668329 15079071 15536066 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17145890 17404308 17550372 17559085 1825141 18272812 19171876 19833085 20038811 20138012 20819927 21149606 21224476 21411734 23430059 24658051 26755705 2965306 6425450 8383323 8580069 8641346 9743347 9834059 9864217
IFNG TLR2 â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10485906 11489965 11579131 11672593 11777960 11870632 11964313 12413632 12818165 14607900 15634932 15778339 15811952 15814715 16267105 16286920 16424049 16713974 17016554 17559085 1825141 18272812 19833085 20038811 20819927 21149606 21411734 24658051 26755705 2965306 6425450 9834059 9864217
IFNG HIF1A â—¼   ENZYMATIC_REACTION ✅ 31.0 1.0 ACSN 10485906 11489965 11579131 11777960 11870632 11964313 12413632 12818165 14607900 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 1825141 18272812 19833085 20038811 20819927 21149606 21411734 24658051 26755705 2965306 6425450 9834059 9864217
IL4 IFNG â—¼   DOWN_REGULATES ✅ - 17.0 1.0 ACSN 10485906 10820262 11160275 11371360 11870632 12401408 12433365 12496409 12818165 18250477 1825141 20184663 20856220 21097505 23124025 2965306 9834059
IFNG FOXP3 â—¼   DOWN_REGULATES ✅ - 31.0 1.0 ACSN 10485906 11489965 11579131 11777960 11870632 11964313 12413632 12818165 14607900 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 1825141 18272812 19833085 20038811 20819927 21149606 21411734 24658051 26755705 2965306 6425450 9834059 9864217
NFKB1 IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 12759422 21642544 21243522 9374532 10227974 16481345 17556653 19732956 21224476 14662860 12757742 18690006 17407192
FOXP3 IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 20554955 17028180 23543754 19877017 17377532 20308632
RELA IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 17035338 12759422 12105194 21243522 9374532 10227974 20643337 19929594 19732956 21224476 23195252 23667107 12842891 14662860 12757742 18690006 17407192 10075983
JUN IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 20006311 22123848 14734615 15187132 11943142 20304822 17556653 1314139 17105733 22413812 19265145 11801649 16713974 7759501 12836278 15522880 12626576 9558063 8756632 18641343 22351517
SPI1 IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15345588 19502584 12130529 7814871 9545284 20585034
FOS IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19285436 16713974 7759501 8756632 12842891 12432566
TBX21 IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 53.0 1.0 Omnipath 21540308 15684054 23041064 23334414 23761633 19631565 10761931 21983879 19286569 17923685 21642544 16713975 19818655 19879772 20977921 26749212 21151104 27324129 12893768 20574006 21624129 16520391 23768572 12938094 21507199 23232398 16473879 21518797 15684083 22078635 17624433 15007632 18178806 23616576 24006458 27226296 19348920 22772450 22521571 12370350 16737784 16434488 17195845 17541280 24584090 17301952 17705132 24752800 20056084 16785492 16498264 26714756
IRF8 IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 19074829 21731497 10092656 12429737 21862594 12370291 10358195 2111015
PDCD4 EIF4E â—¼   DOWN_REGULATES ✅ - 7.0 1.0 ACSN 12482958 17053147 17968323 17991735 18372920 19356152 23070007
EIF4E HIF1A â—¼   UP_REGULATES ✅ + 16.0 1.0 ACSN 10403805 11566883 12080085 12829734 13130303 15451019 15563472 16887934 1823643 7539918 8943284 9155017 9159130 9278421 9746763 9878069
PTEN AKT1 â—¼   DOWN_REGULATES ✅ - 22.0 1.0 ACSN 10753747 11747822 12040186 15721744 16288286 16982858 17218262 17409395 19440036 19847259 19945467 20609352 21084277 22179046 22465479 23732914 24030100 24254977 25364523 26597054 27328425 27572739
PPARG PTEN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18065496 16775433 16425225 23867870 20198337 11378386
AKT1 PTEN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 19903340 15987703 10790335 20596030 10592173 20605778 10866658 12077256 11035045 16107342 12297295
PTEN PIK3CG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16288286 10648629 17218262 12040186 15584861
PTEN AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 15205473 24480624
FOS TGFB1 â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 15067049 15749884 16243976 16327802 16393692 16394015 16413922 16713974 17404308 17485448 19667062 20547845 21372296 21385848 22634314 23390297 23430059 9064320
USF1 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 18955796 21389977 14757763 16457817 15983197 16488890
PPARG TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 14702344 17625041 31023188 17995524 16321227 18615188 14693716 12711314 16611854 18991162
RELA TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 19385047 23195252 28148567 14600158 16365456 21255844 15051419
HIF1A TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16896927 17053163 15611046 19211927 21209004 21057546 21055290
JUN TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 8058069 16327802 16730810 23437118 8183578 16365456 22429882 23936544 15546613 10843986 16978906 23762330 7521696 8631909 12794825
PPP2R5D AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 19131971 10026142 10995457 18042541 18559511 16680151
RELA CXCL8 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 15079071 15536066 17550372 19171876 23430059 8383323 9743347
HIF1A CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17082639 19491109 17488804 21925595 23144021
PPARG CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 19395102 18485432 20107546 20554962 16303327 20889551 15331599 12695526 15720834
JUN CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 37.0 1.0 Omnipath 18684922 16701870 24048734 14686613 24284797 15057743 12643600 17197543 11864912 10817569 12218154 22031759 17586662 10969814 19064995 12716652 27856305 25582859 17471497 22095787 16818736 23176534 14670967 18435575 16846747 19734226 16299055 14612204 18772138 19132242 12209633 15939312 16834785 11399048 11120852 25567680
RELA CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 129.0 1.0 Omnipath 12820969 24337575 15289496 9405619 9698090 20038977 15057743 21665565 24260304 10817569 14631383 10969814 15005855 19668231 16325549 19732956 8207232 18281166 27856305 23894194 9388261 26340924 10975857 10745031 20194077 10928981 16553947 17565687 16764699 22848596 15531761 16105834 16803583 9510190 15355994 18221537 12643600 20053934 11716760 8617886 12218154 12707271 23637609 27076634 8878392 17917246 12163591 16829531 16818736 14670967 12038622 15958549 18362169 8413215 19734226 23386688 11297551 15950427 17362989 16455661 27371733 11953364 8413306 18074095 11973337 18786178 19376732 19837667 17276517 15517885 11342414 18669446 7876168 15350531 14645117 22891766 18034886 11564889 12748173 17586662 18996370 15223809 17041011 12485925 16004996 15079071 21343296 26618242 18435575 17636245 22340043 19173296 24634218 11120852 10477716 21343177 12058956 17045242 19786024 24048734 24770886 10202011 18309103 11864912 21131967 19064995 10530453 12716652 16418726 28283022 18723827 17040605 21255844 15615716 17932106 19966855 20696864 15387324 21451502 15722553 15879558 12855659 12883201 15688424 18045535 10506755
FOS CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 11973337 18317936 12218154 22095787 12748173 10969814 15005855 17586662 16818736 24048734 14686613 16846747 15057743 15615716 8999951 25567680 19173296
NFKB1 CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 75.0 1.0 Omnipath 9510190 12058956 11973337 18786178 17045242 15289496 16701870 19376732 19837667 9698090 17276517 11512674 19786024 20038977 10202011 15057743 15517885 12643600 11342414 7876168 15350531 18034886 11716760 11564889 11864912 12218154 12707271 10969814 12748173 14631383 16325549 17586662 18996370 19732956 17041011 10530453 18281166 12716652 16418726 12485925 16004996 9388261 8878392 17917246 10975857 10745031 10928981 16553947 16818736 14670967 18435575 12038622 15958549 17040605 8413215 21255844 22340043 1401924 9452482 16764699 11297551 15950427 15387324 15879558 16105834 11953364 15688424 18074095 8413306 11096450 16803583 10506755 11120852 10477716
NR3C1 CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 24500711 27371733 15879558 19307749 15355994 21474440 1592440
JUN FOS â—¼   PHYSICAL_INTERACTION 21.0 1.0 ACSN 10606235 11274345 11274400 14673140 15067049 16393692 16394015 17439715 18222063 18754863 19667062 19846528 21385848 21790308 22381618 22634314 22723415 23430059 26587781 8545107 9064320
JUN FOS â—¼   PROTEIN_INTERACTION 21.0 1.0 ACSN 10606235 11274345 11274400 14673140 15067049 16393692 16394015 17439715 18222063 18754863 19667062 19846528 21385848 21790308 22381618 22634314 22723415 23430059 26587781 8545107 9064320
NR3C1 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 20499359 8639160 2169353 9731701
JUN F3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23038262 11057875 20671239 15201277 15636197 7615158 9585253 9081693 8647847 14603525
JUN FOS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 2513130 14561487 8617996 8934539 19255142 9217081 12760745 2498806 10521486 8597411 10858536 12392213 9819441 1380150 23562910 1944274 9867253 9571041 1900040 2511006 14684847 15467742 12231642 11950097
JUN GJA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8606973 16978907 12064606 15618352 10421804
JUN EDN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16740983 1918021 22301113 21239258 12208352 21216243
JUN FN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 24342046 21479385 11052809 9756884 23744703 10325245 11896591 10421838
JUN IL4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 8996240 10772943 9889198 9133600 21989417 9310836 15546613 21454593 12594266
JUN SERPINE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 11440364 12390531 19887897 19288028 15069077 22926518 10591684 11223948 12905745 14592829 16105028 17890327 21969564 8917435 8342330 19088796 20351105
JUN IL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 20557936 12370343 10700231 12884855 8436291 9541574 8397339 1737937 9605137 8683110 21832163 9590239 7989759 9774418 16116194 8473495 8114694 10878360 10320367 9233628 7642615 17097050 7565732 8468462 8660843 7739550 8051409 1740667 19181930
JUN PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 11901151 16001969 19783677 15238218 23523690 10668496 16007171 12057991 22472290 18294142 16339564 17556653 9830045 9988750 19825968 15994313 15772294 9620167 9686761 15525691 11356200 16256955 11234900 18097055 11980644 9705326 19522015 11278336 18282182 12086396 10811116 20237399
JUN ELN â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 11967999 1281483 11557580 10559225 1637804 12135766
JUN SPP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15557322 15790955 20339243 21467818 19880446 14990565 16491116 17360982
JUN CYP19A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 19022561 16810058 21393445 15688015
JUN SPI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17283046 10411939 9178763 9988737
JUN EGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 15075211 15772294 19937979 15375216 10617690 18625220 15238218 7629150 8885243 12954631 10973489 16214953 14518567
RB1 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10026157 9545246
AR JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 11577103 11518798 9211894 8798722 16713569 9591784 17721441
FOS JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 73.0 1.0 Omnipath 20498278 16714286 21675959 25609649 23602568 9872330 20102225 8380166 18848838 18535250 2516828 8397339 15867431 18172215 9346889 10779323 9732876 16928824 26496610 15994313 22719067 24029232 16511568 20195357 11053448 20936779 26186194 18619508 20511396 16008525 10488148 21199371 8617242 17440114 16055710 15319445 11090181 9160889 23661758 1631061 15718494 11431474 31515488 8440710 7816143 20410304 34671206
PAK2 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21177766
RELA JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18174238 9468519 16713569 10488148
CREBBP JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 8028671 10327051 2138276 9659924 9786917 16713569 17296604 8545107 18443043 16055710
MAPK8 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 202.0 1.0 Omnipath 17143273 17804415 10617656 8846788 15958389 11948398 10882101 20028971 12697749 15894542 20514406 14612408 17875713 9891069 17570479 18922473 11809792 8586671 11896587 12185592 12871843 7992057 7600582 11278395 8137421 8001819 10493750 14557262 16549498 18707149 9169478 11460167 15289320 8157646 16007099 20506250 22110360 15378002 9687508 12740383 20732415 9305638 19270716 23331499 10747973 16291755 16393692 12832416 18988627 10713700 18669648 12087092 14633987 8525045 15677475 16076903 16166642 18650425 15590691 1608942 19910486 18212344 11562357 12228228 16740711 14701799 19690332 10871633 12531896 16713569 8654373 16983342 19664995 15302935 10962563 15068801 8621542 8607977 18362184 10393177 20068231 9808624 14572659 8224842 10585392 9407028 17363973 19527717 19436832 14517282 12407442 9487126 9692890 14523011 15212693 10908726 11108663 13130464 10064600 18429822 15299005 9774977 11907583 12963725 16824735 19413330 10617104 17055484 21071413 18452278 16434970 16157600 7737130 23816567 10987838 17189706 9561845 9575168 1460037 7652575 18617513 24113186 11971971 11801649 25098452 20058876 16533805 9184210 18003900 9315636 10385525 18957422 12881422 11274345 12052834 15749833
JUN SPI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12393465 10411939 12091339
NFKB1 RELA â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
RELA IL2 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 10679398 12133954 12759422 14668329 15079071 15536066 17145890 17404308 17550372 19171876 20138012 21224476 23430059 8383323 8580069 9743347
RELA AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 24466341 16619263 14576180 15517885 14715080
RELA CSF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 10919279 11949945 21825016 21895511 21106671 18566389
RELA IL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 7623820 8814256 22427656 9417120 9605137 15477007 9111330 21832163 9135552 8383323 8934574 11035116 7730629 16275766 9737979 19968887 28199730 1604322 15585831 8977179 12027419 18045535 18207244 17179947 23578476 15710339 9233628 11145913
RELA AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20186924 18031796 20649564
RELA SERPINE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12675842 10839991 15631825 11757833
RELA EDN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21334436 10969841 18226221
RELA IL4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 15048722 14688382 19915002 20139176 8524816 12516545 8135784 8083467 21989417 25037220
RELA CCL11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 22254182 18714023 15531761 16604092 11076795 15972682 10586089 14660485 16428072
RELA FN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10649441 18064631 10867646 22223884 12372417
RELA NFKB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 16778171 20427719 23362108 16513645 1740105 20596645 16513841 19469019 8454856 21420936 16135789 9417120
RELA F3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 15242552 11057875 12746898 9867853 18226221 19167713 7615158 7929355 9081693 11157486
RELA PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 43.0 1.0 Omnipath 16001969 9266823 19783677 12471036 17673602 10827178 16210649 20669087 12466023 15517885 15013753 12622742 20600530 14645117 18294142 19618291 12067569 15655349 17556653 18973191 14988266 12871860 20103608 19284764 15555528 21149600 11082190 15234907 9041934 22001128 16820889 18752821 19766095 15997464 8995303 9710122 12349897 15387324 15368354 18057724 15547942 16624933 17767925
RELA HIF1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18498249 17898080 23185316
NFKB1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 88.0 1.0 Omnipath 17145710 16209943 25609649 8428580 12947093 16970925 17072323 2050119 15657065 21270162 11976329 16793322 21544861 22261743 8657102 9824778 11880271 9450761 17962807 21988832 25355951 9722548 18215660 14743216 15799966 10799898 16105840 15218526 8798655 14690596 22139845 22808155 11571291 17072327 16740634 10498867 8255759 8246997 15214841 16846590 15371334 16285893 17072322 17855547 18321863 16493424 7479976 15145317 17561400 20110362 9426183 23687337 12414801 11970949 20154269 20237821 24175631 24634218 34100597 14645533 17982102 21763497 16204234 9437432 20547752 15818410 7628694
CREBBP RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 10542243 14597638 18241676 17138826 15140884 9096323 16713569 12456660 10454579 16382138 19608861 9806899 25314079 11931769 12163591 12881425 9659924 15171256 9548485 16291753 17362989 25733689 17434128 15334063 15806143 10235267 17296604
NR3C1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 23871663 10995388 7659084 8290595 16713569
RELA NR3C1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 23871663 10995388 7659084 8290595 16713569
NR3C1 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 24811171 27777311 10649448 8754811 11279134
PPARG PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 11278336 16506021 19578162 20234816 10827178 14555539 11412039 19997048 20656057
PPARG SERPINE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 10329404 15990085 18278065 14581151 17906687 17995524 10073956 16843437 11230363
PPARG TNFRSF11B â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11485016 20150512 12056809
PPARG IL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 19217272 16611855 10671476 15187132 11726648 19712756
PPARG FN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 19466435 18278065 15908479 16321227 14693716 12055599
PPARG LPL â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17658475 10098492 8895578 18948972
PPARG AGTR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20890053 11416035 11409645 16938288 22282354
MAPK8 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 9030579
IL13 IL18 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10485906 11867689 12223527 12401408 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26755705 27216177 7512720 7521688 7543512 9535722
IL4 IL18 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23390297 24030977 24091328 27216177 2965306 7512720 7521688 9834059
IL18 TBX21 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 10679398 11592085 14504095 14662834 15099563 15802534 26885855 27048821 27066895 9469432
RUNX1 SPI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23817177 19339695 20972335 24037986 18316480 19208846 17994017 12576332
SPI1 FLI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10523830 9858537 23056458
SPI1 CSF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 8622667 25574134 9632776 9988737 12130514 10080908
SPI1 IRF8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10570299 9593745 10734131 17386941 11483597 17200120
CD28 IL2 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 10426994 11907067 1313950 15197224 15536084 16713974 22437870 7523569 9359474
IL2 TBX21 â—¼   ENZYMATIC_REACTION ✅ 21.0 1.0 ACSN 10807786 11280761 11460167 14660645 15289500 15563472 17301840 1825141 18264787 18758473 19528259 21133840 21232017 22224781 23650441 24699077 24958845 26755705 2965306 6164929 9625766
NFKB1 IL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 17641034 1777483 7623820 7744006 8834450 15477007 8254209 9111330 9135552 8383323 11035116 7730629 15079071 2848811 9737979 1707162 19968887 7957556 1604322 8977179 12027419 17491020 18207244 8814256 9233628 11145913
TBX21 IL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 24006458 10761931 16275766
RUNX1 IL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17466384 22253733 17377532 21292764
FOXP3 IL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 22.0 1.0 Omnipath 25567984 23275607 22806628 21458306 17028180 16873067 21955384 17586580 23954131 17922010 20429413 18324310 19172156 17416586 22579476 18779564 17430097 21654845 17632414 11483607 18759924 19564342
FOS IL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 20557936 8893011 11260070 11685114 8397339 1737937 9605137 9590239 11262396 7989759 1916630 8473495 10601992 8114694 22474330 18725523 9233628 11385624 2518655 15170389 8468462 7565732 12432566 8660843 7739550 1305903 20680391 19181930
ARNT CREBBP â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 11959990 11063749 7836384 11959977 9632793 17804822 9822602 10202154
CREBBP LEF1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 10769018 11050151 18160704 15060161 11973335 10775268
HIF1A CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12542982 20547241 17452336 15907483 19489936 15342390 15184875
AR CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9822653 15350180 16492776 16344550 11161315 18819102 18031230 20610535
CREBBP AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 20541699 9822653 15691881 12810069 9482849 16713569
IL4 TIMP3 â—¼   ENZYMATIC_REACTION ✅ 31.0 1.0 ACSN 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20856220 21115385 21840487 23124025 23390297 24030977 24091328 27216177 2965306 7512720 7521688 7543512 9834059
IL4 IL13 â—¼   ENZYMATIC_REACTION ✅ 17.0 1.0 ACSN 10485906 10820262 11160275 11371360 11870632 12401408 12433365 12496409 12818165 18250477 1825141 20184663 20856220 21097505 23124025 2965306 9834059
IL4 INHBA â—¼   DOWN_REGULATES ✅ - 31.0 1.0 ACSN 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20856220 21115385 21840487 23124025 23390297 24030977 24091328 27216177 2965306 7512720 7521688 7543512 9834059
IL4 CSF1 â—¼   DOWN_REGULATES ✅ - 17.0 1.0 ACSN 10485906 10820262 11160275 11371360 11870632 12401408 12433365 12496409 12818165 18250477 1825141 20184663 20856220 21097505 23124025 2965306 9834059
IL4 HIF1A â—¼   DOWN_REGULATES ✅ - 17.0 1.0 ACSN 10485906 10820262 11160275 11371360 11870632 12401408 12433365 12496409 12818165 18250477 1825141 20184663 20856220 21097505 23124025 2965306 9834059
TBX21 IL4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 18504404 18819071 19348920 22521571 15684054 20193034 17195845 17541280 23232398 23768572 16473879 21983879
FOXP3 IL4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20554955 20573297 18395799 19775525 18374871
NFKB1 IL4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 14688382 8524816 12516545 8135784 8083467 7807002
IL13 HIF1A â—¼   DOWN_REGULATES ✅ - 11.0 1.0 ACSN 12223527 12401408 14610620 14657224 15099563 18250477 18451175 20184663 21097505 26755705 9535722
IL13 INHBA â—¼   DOWN_REGULATES ✅ - 32.0 1.0 ACSN 10485906 11867689 12223527 12401408 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26755705 27216177 7512720 7521688 7543512 9535722
NFKB1 CSF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18566389 10919279 11949945 7583532
SMAD6 TAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 11737269
ARNT HIF1A â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
NFKB1 HIF1A â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 17272744 18393939 21725609 23178297 23572150
HIF1A IGFBP1 â—¼   ENZYMATIC_REACTION ✅ 66.0 1.0 ACSN 10102273 10428030 10428780 10435632 10804084 10823814 11557773 11559532 11744734 11756417 11884613 12402042 12676992 12743597 14672622 14684737 14699081 14762718 15024076 15059920 15199147 15240700 15312748 15369676 15379897 15545625 16110315 16126909 16127144 16517405 16517406 16585195 16782875 16888645 17143338 17418790 17533374 17785433 18054315 18056423 18158893 18718909 19211554 20028863 20427344 20535745 20855962 21051947 21765015 22006996 22841746 22850421 22988108 24006507 25043024 25103413 25732824 7493931 7500013 7508926 8089148 8702901 8955077 9486205 9525945 9707622
HIF1A PDK1 â—¼   ENZYMATIC_REACTION ✅ 66.0 1.0 ACSN 10102273 10428030 10428780 10435632 10804084 10823814 11557773 11559532 11744734 11756417 11884613 12402042 12676992 12743597 14672622 14684737 14699081 14762718 15024076 15059920 15199147 15240700 15312748 15369676 15379897 15545625 16110315 16126909 16127144 16517405 16517406 16585195 16782875 16888645 17143338 17418790 17533374 17785433 18054315 18056423 18158893 18718909 19211554 20028863 20427344 20535745 20855962 21051947 21765015 22006996 22841746 22850421 22988108 24006507 25043024 25103413 25732824 7493931 7500013 7508926 8089148 8702901 8955077 9486205 9525945 9707622
HIF1A FOXP3 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 10804084 16110315 16127144 17533374 20427344 20535745 20855962 21051947 21765015 22006996 22850421 22988108 24006507 25043024 25103413 25732824
HIF1A SLC2A1 â—¼   ENZYMATIC_REACTION ✅ 66.0 1.0 ACSN 10102273 10428030 10428780 10435632 10804084 10823814 11557773 11559532 11744734 11756417 11884613 12402042 12676992 12743597 14672622 14684737 14699081 14762718 15024076 15059920 15199147 15240700 15312748 15369676 15379897 15545625 16110315 16126909 16127144 16517405 16517406 16585195 16782875 16888645 17143338 17418790 17533374 17785433 18054315 18056423 18158893 18718909 19211554 20028863 20427344 20535745 20855962 21051947 21765015 22006996 22841746 22850421 22988108 24006507 25043024 25103413 25732824 7493931 7500013 7508926 8089148 8702901 8955077 9486205 9525945 9707622
HIF1A PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 19106818 16397226 21149600 14507857 16818642 23144021
HIF1A PDK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18269201 16517405 17855495
HIF1A EDN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 19783678 11352889 18411415 17431122 12023962 11278891
HIF1A SLC2A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 19828020 17426252 18097583 15525582 17431122 16025159 17486380 15620252 23661628 18268343 11120745 17322369
HIF1A EPAS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20513003 18174278 16924414 19030186
HIF1A MET â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16099863 17028975
HIF1A SERPINE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 19828020 10590062 11877282 17570486 18381294 9427542 14708599 17721610 15968405 16778202 17197388 19132225 20216986 21132271 14567996 14978738 20136501 17384280 12393531 19490965 8672239 11313255 20351105
HIF1A AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19144925 17220299 17488804 14726529 15277220
HIF1A TLR2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19828020 18159247
ARNT HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 17213817 8816435 17197389 14764593 12393189 12810720 15319539 23363003 9079689 11829741 15479785 26496610 12391259 17916562 24434214 11606485 20562859 9704006 21620138 11782478 20932347 15347669 8927054 21435239 19168635 9159130 14668441 20049704 20603618
RB1 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15674338
HIF1A TGFB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 7539918 8943284 1823643 12829734 9159130 10712429 13130303 11566883 12080085 10403805 9746763 15451019 11790723 9278421 16887934
HIF1A EDN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 7539918 1823643 16716598 12829734 9159130 13130303 9588211 12080085 11566883 10403805 9746763 8943284 15451019 9278421 16887934
CDC42 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 25241761 12213839 25284480 18426980 10930450
CDC42 MAP3K11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 10559936 16253996 23331499 15020669 11340065 15003621 10934474 11413130 17161586 25241761 11950587 9427749 10799501 9829970 11248548 8910292 18719708 10613909 10461188
CDC42 PAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 17145710 8107774 10559936 25416956 10320322 23331499 15020669 11340065 15003621 20936779 10934474 11413130 17353931 9535855 11950587 19628037 32296183 16204230 20696164 11248548 9822598 18719708 10613909 9823899 10461188
ITK CD28 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 19901323 10586033 22936936 8946678 15144186 15592455 16094384 8992971
PDPK1 AKT1 â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 11687500 11747822 12670391 15802604 17680028 18802401 19109239 19122654
PDPK1 RPS6KB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 70.0 1.0 Omnipath 17081983 12429015 15208671 18326039 16286006 11438723 21561857 18802401 19864428 16099428 7545671 7489717 27149630 15388791 12183455 10601311 9465032 26582459 29257917 12967624 24604594 15718470 9427642 10209156 23769967 12586835 15809305 9218810 11500365 14560963 9271440 20932932 12370290 11914378 11684675 17680028 14993219 19570988 9445476
PDPK1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 156.0 1.0 Omnipath 15505410 12538620 12176337 19951971 24352480 11752451 19401591 11369519 10698680 10601311 15718470 24950409 20481595 24169049 10570282 16798838 14993273 11500365 9368760 19844585 17680028 7637810 9169478 26256536 7722458 9094314 12750173 11438723 18802401 9252186 23331499 18456494 9104825 10592173 16189514 20361045 18988627 11278835 20163786 20333297 20041157 12808134 19602588 8630736 10207050 11241670 10438924 9868760 25912234 20153221 25582703 11445557 21775285 12149249 14666721 18596232 9512493 23397142 11809791 12167717 21798082 16033886 10679787 16787925 29562639 15550174 21071413 8978681 10833263 19203586 10226025 26937223 14500673 20161206 11136732 11825911 11042193 9642236 22569334 18662999 9736715 12242303 11313365 11598012 11134526
FOXP3 IL17A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20221429 19877017 23409930 18434325 19088203
TBX21 RUNX1 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 10761931 12055627 12802010 14614857 15084276 16410834 17440449 18768831 26885856
EPAS1 SERPINE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 20061373 16778202 17570486 20039838 15039136 17804822
USF1 SERPINE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 18234320 12235287 19132220 15372465 16902162 16457817 16622840 14765999 16330554
PLG IGFBP3 â—¼   CLEAVAGE ✅ 10.0 1.0 Reactome 8817670 7527330 17047378 8964575 11739083 7588299 8894645 12466191 12379487 10990447
PLG F2RL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 12604689 10978167 9020112
TNC FN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 7499434 20708078 21349332
SMURF2 SMAD5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 20484049 15221015 22298955 15231748
SMURF2 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 14701756 23331499 15221015 11016919 22298955 11158580 32296183 15231748 20937913
AR EGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 18511414 8580999 7522959 15590903 14662770 18692155 17374439 18212060 20610535
EGF ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15748904 23331499 12093292 11279155
USF1 SPP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10413606 15557322 12200434 18307922
VDR SPP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 20713445 7705332 20227497 23644099 7981122 8119880 16195230
SMAD1 SPP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10625647 21467818 19664780 20965237 14672939 21276840
NFKB1 PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 9266823 20669087 12471036 17673602 10827178 16210649 12466023 15517885 12622742 18294142 19618291 12067569 15655349 17556653 9988750 18973191 14988266 12871860 20103608 15555528 11082190 15234907 22001128 16820889 19766095 15997464 12349897 15387324 15368354 18057724 15547942 16624933 17767925
NR3C1 PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 10631313 18945810 10827178 18657608 9918831 19797430 10701683 18650268 16198345
USF1 PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 15205395 17186551 11356200 15927963 14660559 18817855 17074806 11967217
AHR PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18001219 12548657 15213229 19056653
FOS PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15772294 11278336 9620167 17556653 12057991 8906578 17440114
PTN IRS1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 23201355 16878150 29455642 15226403
AKT1 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17570479 17640984 10497255
RPS6KB1 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 47.0 1.0 Omnipath 21283818 17081983 16953237 24931005 11287630 15249583 27898058 16914728 25379019 23565163 15364919 15533996 19121779 9312143 17709744 20074531 22523661 23958494 16129690 23006971 23898460 26474286 28342808 17507185 25813876 26926384 15306821 20932932 34013180 15199052 18498745 18952604 18220336 12006582 19369195 29496905 27889207 26666849
MAPK8 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 41.0 1.0 Omnipath 15001544 18728222 26882989 12409308 10592173 15314024 12417588 15613682 14579029 10722755 26538579 29207597 15199052 12351658 16055440 11606564 12510059 15212693
IRS1 PIK3CG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12767520 10826997 12444011 21540285 11943559 23331499 19030972 16931767 12175651
VDR IGFBP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 14963110 23770368 20855290 18212051
AR AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 20589722 11278645 17896924 18687691 22740037 12621049 12063252 22970326
PPP2R5D AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 18039929 19216069 10026142 10995457 18042541 20452955 18559511 18588945 16680151 16406523
PDK1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 12176337 15743829 12682057 11445557 15899889 12149249 10833263 15718470 11278835 10226025 11087733 14500673 16341064 19897009 9368760 24012393 11825911 9512493 9736715 11313365 9868760 15364915
AKT1 HSPB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 12740362 11042204 19593530 22983196 17510053 23397142
AKT1 NR3C1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 27997540 24291004
AKT1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 17470458 18349820 29861848 16210317 21601007 17570479 11404460 22155408 12621049 14555644 11156376
AKT1 PDCD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 17053147 17081983 18296647 18187866 17287340 16357133 16964243 18669648
AKT1 MAP3K11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 26152725 17570479 12458207
AKT1 MST1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23331499 12919677 14505491
AKT1 RPS6KB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11943559 23331499 25241761 21071413 12183455 15149849 11438723
AHR FOS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14973392 10478842
NR3C1 FOS â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 16850320 9804760 1314076 8036015 8890955 8733011
SRF FOS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 45.0 1.0 Omnipath 9315625 10742173 8864058 8986626 19581295 9690619 10777594 11846562 12242287 2104799 17938209 9111305 8007980 12760745 11862715 1902475 8423791 10642500 10330504 10961986 9032300 2511007 8164681 7854423 17182846 2200737 9271374 10369679 8413226 19173292 9349499 1630900 8262053 10319327 7910456 9545312 9571041 9734357 8764983 12231642 2493627 14693367 18557893 7588632
NR3C1 NFKB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 8639160 17016446
NFKB1 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 14576180 15517885 20159994 12165860 16619263
NFKB1 F3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15242552 20303465 11057875 12746898 9867853 19167713 11157486
NFKB1 CCL11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16604092 11076795 15972682 10586089 14660485
NR3C1 NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16713569 8290595 16380507 7823959
RB1 CDK4 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 Reactome 10207050 9447971 24876129 31543423 11416152 11032757 9190208 30711375 10499802
CDK4 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 107.0 1.0 Omnipath 26203195 10498883 23336272 9315635 17303408 17363486 25803170 10359571 15081408 16236519 28249908 16936279 17478427 19690332 11520855 31615938 15279786 16326706 18981099 9190208 8626527 14627988 7575488 24417566 9003781 16360038 10385618 9736735 9139732 7736585 20068231 34158578 16189514 19075565 18669648 11773438 11641415 21880723 18590585 27708221 10962560 20068082 15489884 9425340 19225156 19551155 17045206 10210318 19262748 18786381 17660363 17621266 19651622 12657252 11746527 11254678 15809340 22263797 10202152 10778858 27811360 23981302 19664994 14676836 9380698 18583321 23429262 27430527
ITCH TXNIP â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 10940313 11318614 16469705 16861923 18552861 18628966 20068034 21107885 21383157
MAPK8 ITCH â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 23435430 16469705 15358865 16446428
PDK1 RPS6KB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 11914378 17110931 12370290 15388791 15718470 16286006 20068231 9465032 15809305 16099428 14560963 11279232 9271440 9445476 18669648
RPS6KB1 PDCD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 33.0 1.0 Omnipath 17053147 19339977 28692058 16286006 19901084 27028868 20647036 11108711 23415227 12482958 18296647 18423201 23466868 21233202 25573956 19720745 12713446 16357133 21378410 28899909 15905173 20661426 20832730 24405715 17052453
AR FN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14521927 21055159 20610535
SMAD1 SMAD6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10692396 17215250 22219353 22072987
CTDSP1 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 23331499 16882717 17085434
SMAD6 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 23331499 9256479 9335505 9436979 21071413 18988627 11483516 12857866
PAK2 PRL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 19555049 11943200
AR CYP19A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 11427738 12600681 10940736 2289019 17520059 20610535
NR0B2 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23331499 16713569 11735420
HSPB1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 19767773 17974989
NR3C1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 16713569 9162033
MAPK8 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 24424504 21512132 21820033 16282370
AR NR3C1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 16713569 9162033
MAPK8 RPS6KB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 21988832 17570479 11279232 23816567
MAPK8 NR3C1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 12351702 18337589 9482836 9199329 18669648
CCL11 CCR5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 10477718 9468473 10699158 9790730 11264152 22633458 12964882
NR3C1 AGT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20978123 15630592 17475670 15854165
AGT AGTR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 12006574 21464395 10193788 10993080 16189514 15930094 9797979 16597412 17346243
ARNT AHR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 17145710 8621524 8384309 9887096 20006590 10395741 18096572 12024042 7628454 9704006 19380484 17823304 11259609 19390533 22138065 8631989 8619634 8065341 11768231 7488247
ARNT EDN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 7539918 1823643 16716598 12829734 9159130 13130303 9588211 12080085 11566883 10403805 9746763 8943284 15451019 9278421 16887934
SMAD5 SMAD6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10692396 16436528 22219353
INHBB FST â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 7678220 8033815 12697670 1592877 16198295
INHBA FST â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 7678220 8033815 12697670 1592877 16198295
FST INHBA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 16198295 24627466 7887917 22037168
WT1 GATA4 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9815658 11207191 18445271 11278460
GATA4 EDN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10788492 19546173 18252717 11739382 11435416 12724418
NR0B2 CYP7A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 19346330 15314177 23038264 21566081 18323469 19805516 11030332 20375098 15358835 15817812 21817852 12525500 21963511 17145766 17654698 19085950 19056864 16049268 15581596 11518759
WT1 VDR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11373341 11050081 23362234 11773605
VDR CYP7A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19106115 17054913 20371703
MST1R MET â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 14559966 16849525 21496277 12746450 19450681 8208547 23618918 21455220 8302603 17967179 21247903 1655790 12611639 15475459 26670562 16914575 33839159 10871856 33727228
SRF TAGLN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 18805960 12791591 14654367 9545312 11279108 21673106 11988486 16690609 9242426 14975939 12023898 15217807 15242862 9121477 19776005 20511232 14970199
TLR2 SFTPA1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 16834340 12817025 16213021 11724772
INHBA BAMBI â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10918299
FBLN5 ELN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18267938 19570982
NKX2-1 SFTPB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 12161428 9252399 11274148 20418387 8065304 11152647 9396717 10710519 18003659 16500948 19906647 9211870 9006959 16183668 16507635 16960125
TTF1 SFTPB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 9252399 10867648 11274148 20418387 11004479 11152647 8928820 16461352 12882447 16630564 10830305 23845988 16183668 11053014 9006959