TCF7L2
|
BCL2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17404573
23671559
|
BCL2
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15210690
|
CCND1
|
RBL2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
11157749
9144196
|
HDAC1
|
CCND1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20049841
20821348
|
TP73
|
CCND1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
16526280
22842668
|
CDKN1A
|
RBL2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
11157749
9144196
|
RB1
|
CDKN1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
9671466
14527674
|
RUNX1
|
EP300
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16917507
5218981
|
EP300
|
CREBBP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
23403292
24998469
|
ESR1
|
EP300
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16704985
11279135
|
TP73
|
EP300
|
â—¼ ACETYLATION
|
✅
|
|
2.0
|
0.8
|
intact
|
11804596
5215037
|
EP300
|
RB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16374512
11433299
|
EP300
|
FOXO3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
11896584
|
FOXO3
|
HBP1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
12351634
|
FOXO3
|
RBL2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11884591
|
MAPK14
|
RB1
|
â—¼ PHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
intact
|
17380128
5219804
|
MAPK11
|
MAPK14
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23602568
21900206
|
HBP1
|
MIF
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
20383199
|
RUNX1
|
MYC
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
29958106
|
EWSR1
|
MYC
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
8164678
11423975
|
MYC
|
TNF
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15466196
12080469
|
ESR1
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
3677090
|
RB1
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
7838535
|
HBP1
|
TNF
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
18218727
19158276
|
TP73
|
TNF
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
21933882
17725714
|
TP63
|
TNF
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23071313
21933882
|
BECN1
|
TP63
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
0810452105
19050071
|
TP73
|
TP63
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
19815500
0905867106
|
TP63
|
IL2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
2196176
9032395
|
CASP8
|
TP63
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17581882
|
CASP8
|
TP73
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18362891
|
RB1
|
HDAC1
|
â—¼ PROXIMITY
|
|
|
2.0
|
0.8
|
intact
|
29997244
20178071
|
IL1B
|
CASP8
|
â—¼ CLEAVAGE
|
✅
|
|
2.0
|
0.8
|
Reactome
|
1574116
22267217
|
ESR1
|
CREBBP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
23403292
24998469
|
EWSR1
|
CREBBP
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
8552387
12459554
|
HBP1
|
IL1B
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
19158276
18173740
|
HBP1
|
RUNX1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16179914
|
RUNX1
|
MPO
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15676205
|
SMAD1
|
HBP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
15231748
5217094
|
KIFBP
|
HBP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16713569
5218676
|
HBP1
|
EWSR1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16713569
5218676
|
HBP1
|
RB1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
18031610
16966377
|
H1-2
|
H1-0
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
000924
30021884
|
EP300
|
HDAC1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.81
|
0.81
|
HIPPIE
|
14968110
30110629
22778253
16787918
33742100
18722353
22731250
|
MYC
|
RUNX1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
21150319
29467282
|
UBE2H
|
WDR26
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
27173435
29911972
|
CREBBP
|
FOXO3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
822.0
|
0.82
|
STRING
|
36370105
|
HBP1
|
HDAC1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
15235594
29911972
|
CCND1
|
EP300
|
â—¼ PHYSICAL_INTERACTION
|
|
|
835.0
|
0.83
|
STRING
|
36370105
|
FOXO3
|
EP300
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
19592618
25609649
11896584
|
MAPK14
|
RB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
839.0
|
0.84
|
STRING
|
36370105
|
CDKN1A
|
EP300
|
â—¼ PHYSICAL_INTERACTION
|
|
|
846.0
|
0.84
|
STRING
|
36370105
|
RUNX1
|
EP300
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
14752096
16917507
|
EP300
|
SMAD1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
10205054
20851880
22365546
16613856
10673036
|
MAEA
|
WDR26
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
31285494
27173435
29911972
|
HDAC1
|
RUNX1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
854.0
|
0.85
|
STRING
|
36370105
|
CASP8
|
BCL2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
16183855
11406564
|
CCND1
|
ESR1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
867.0
|
0.86
|
STRING
|
36370105
|
ESR1
|
FOXO3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
868.0
|
0.86
|
STRING
|
36370105
|
MYC
|
EP300
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
15616592
16287840
32140074
16126174
17157259
12776737
|
ESR1
|
FOXO3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
18312651
11435445
|
EP300
|
TP73
|
â—¼ PHYSICAL_INTERACTION
|
|
|
875.0
|
0.87
|
STRING
|
36370105
|
ESR1
|
HDAC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
877.0
|
0.87
|
STRING
|
36370105
|
CREBBP
|
ESR1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
878.0
|
0.87
|
STRING
|
36370105
|
EP300
|
CCND1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
15951563
10567390
11788592
|
HBP1
|
SIN3A
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
15235594
29911972
|
BECN1
|
BCL2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
22498477
21971985
20889974
20010695
23504944
23564079
23168911
25891078
29955058
23822101
32097085
23954414
19959994
28128446
22241963
16179260
23316280
31410188
18641390
29079782
29849149
28682313
27304906
20711182
25984893
22622204
19180116
20622903
33977871
23541952
24034250
22082873
21543763
19347031
31696776
9765397
16713569
24879154
24141421
17446862
24472739
24599950
28431397
20577262
19050071
32820146
21358617
21139567
23479509
|
CCND1
|
ESR1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
16061635
9039267
11073968
|
FOXO3
|
CCND1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
12391153
21294163
|
SMAD1
|
CDKN1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
19819988
11786386
|
EWSR1
|
CDKN1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
12560328
18757425
20153576
|
RUNX1
|
CDKN1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
10617663
23487742
23150456
|
EP300
|
ESR1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
19887647
11782371
12738788
25728767
11867769
12479814
23065768
15308690
20388208
14761960
22227247
8799122
20348541
23403292
12714702
11581164
16713569
19838210
18765668
16645043
30418174
12574227
|
FOXO3
|
RBL2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
11884591
16493026
|
MAPK11
|
MAPK14
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
intact
|
21900206
2001699
8089645
|
MYC
|
HDAC1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
17314511
18271930
34147029
26496610
30415952
18003922
22286234
24951594
|
SMAD1
|
MYC
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
3.0
|
0.9
|
ACSN
|
15576399
22290435
22761862
|
RB1
|
MYC
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
7680889
10200487
9671466
|
MYC
|
MPO
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12695333
|
MYC
|
HBP1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12747840
|
TP73
|
TP63
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
16413471
21436470
18026135
|
TP73
|
TP63
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
11238924
19815500
10373484
|
RUNX1
|
HDAC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
18316480
10617663
22777353
|
SIN3A
|
HDAC1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
15695521
28514442
9520398
10640275
14647463
12398767
9150133
10444591
14593184
21258344
12943729
12374985
17956988
11102443
9885572
17962807
26496610
12453419
11171972
16331260
20585571
10220385
25314079
12091390
11931768
17643391
11602581
17827154
12724404
11784859
23752268
18059533
9790534
9804427
26949739
24981860
33961781
19182791
11118440
15451426
12920132
26344197
|
ESR1
|
HDAC1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
17312152
31527615
24051437
33731348
14722073
21182205
15557281
18451880
14506733
15140878
|
HBP1
|
NCF1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
18258815
15024088
|
EP300
|
HDAC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
900.0
|
0.9
|
STRING
|
36370105
|
HDAC1
|
RB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
923.0
|
0.92
|
STRING
|
36370105
|
RANBP9
|
WDR26
|
â—¼ PHYSICAL_INTERACTION
|
|
|
927.0
|
0.92
|
STRING
|
36370105
|
EP300
|
ESR1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
930.0
|
0.93
|
STRING
|
36370105
|
HBP1
|
SIN3A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
936.0
|
0.93
|
STRING
|
36370105
|
CCND1
|
RB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
947.0
|
0.94
|
STRING
|
36370105
|
BECN1
|
BCL2
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.95
|
0.95
|
mint
|
19180116
7014480
|
BCL2
|
BECN1
|
â—¼ COLOCALIZATION
|
✅
|
|
0.95
|
0.95
|
mint
|
8095158
21139567
|
RB1
|
HDAC1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.95
|
0.95
|
mint
|
6550000
10779361
|
HDAC1
|
RBL2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.95
|
0.95
|
HIPPIE
|
9858615
9724731
10969803
|
MAEA
|
RANBP9
|
â—¼ PHYSICAL_INTERACTION
|
|
|
970.0
|
0.97
|
STRING
|
36370105
|
BAX
|
BCL2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
981.0
|
0.98
|
STRING
|
36370105
|
CCND1
|
CDKN1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
983.0
|
0.98
|
STRING
|
36370105
|
BAX
|
BCL2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.99
|
0.99
|
HIPPIE
|
21778226
18981409
15899854
32064756
10620799
21199865
17289999
9194558
8358790
21671007
16642033
21458670
22262057
9388232
10716992
20865015
14980220
9111042
24141421
17097560
15231068
9463381
33961781
17525735
29749471
23479509
26004684
|
BCL2
|
BAX
|
â—¼ PHYSICAL_INTERACTION
|
|
|
15.0
|
1.0
|
ACSN
|
11704864
16227588
17446862
17891140
20709625
21641962
22039431
23064052
23377657
23430059
23850759
7644501
8358790
8929532
9872359
|
BCL2
|
BAX
|
â—¼ PROTEIN_INTERACTION
|
|
|
15.0
|
1.0
|
ACSN
|
11704864
16227588
17446862
17891140
20709625
21641962
22039431
23064052
23377657
23430059
23850759
7644501
8358790
8929532
9872359
|
TP73
|
BAX
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
18034190
17346710
18421303
21245298
10559267
18418051
18644986
17521288
19067706
11748232
|
MYC
|
BAX
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
8845569
11103792
12695333
|
BCL2
|
BAX
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
60.0
|
1.0
|
Omnipath
|
17145710
22705850
18981409
9463381
21458670
17097560
17525735
8358790
10620799
26004684
29749471
9388232
21199865
17525161
22262057
21778226
15486085
17289999
9111042
12419244
9194558
15231068
10716992
8183370
14980220
9115213
21671007
16642033
23479509
10677502
|
BCL2
|
BECN1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
16.0
|
1.0
|
ACSN
|
10604474
11704864
16179260
17106237
17446862
17891140
18612260
22039431
22885520
23064052
23377657
23430059
23850759
27754749
8929532
9765397
|
BCL2
|
BECN1
|
â—¼ SHARES_COMPLEX
|
|
|
16.0
|
1.0
|
ACSN
|
10604474
11704864
16179260
17106237
17446862
17891140
18612260
22039431
22885520
23064052
23377657
23430059
23850759
27754749
8929532
9765397
|
MYC
|
BCL2
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
17.0
|
1.0
|
ACSN
|
11274345
11283613
11283614
11704864
17055429
17558397
17873522
20027199
20237412
20551172
20581311
20713526
21406394
2191300
22067385
25002027
28536364
|
RUNX1
|
BCL2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
10208431
24370018
23673926
8943060
|
MYC
|
BCL2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
8036017
17404573
12695333
24167291
18809243
19201832
16316993
19649202
|
ESR1
|
BCL2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
19148464
19160418
9306964
11261829
21841772
10542244
20664923
18414489
|
CREBBP
|
BCL2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
9829964
10753867
17565603
15337521
10454566
|
MAPK14
|
BCL2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
8.0
|
1.0
|
Omnipath
|
29050237
16714293
19336399
11495898
|
BCL2
|
CASP8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
16183855
11406564
|
BCL2
|
BECN1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
72.0
|
1.0
|
Omnipath
|
23504944
17643073
23168911
21971985
19273585
16713569
19050071
16179260
23316280
22205736
23115300
18641390
28128446
17446862
23954414
22241963
23541952
29955058
25891078
29849149
24034250
24599950
9765397
25984893
21358617
18570871
16799551
19180116
20889974
20622903
23564079
19959994
20711182
23479509
19347031
20010695
21543763
22622204
24472739
17438366
|
RB1
|
CCND1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
9.0
|
1.0
|
Reactome
|
10207050
9447971
24876129
31543423
11416152
11032757
9190208
30711375
10499802
|
MYC
|
CCND1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
7526316
21933022
17881732
12835716
14757441
19086036
8552398
19698176
19786833
18809243
18806825
8196642
11085504
|
TCF7L2
|
CCND1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
17108104
17360646
17468517
15026412
12235165
15126340
22005519
22318732
|
ESR1
|
CCND1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
40.0
|
1.0
|
Omnipath
|
11477579
12554765
12808053
17166846
22892083
21505052
18414489
9832502
23864650
22396492
22266855
11358796
23891847
22948256
11986316
15282324
15496458
22521644
14764652
15178330
23108396
11410592
15026472
17998543
17681750
18245487
20821348
16860316
11844790
19858209
12929585
15808510
18997820
15217513
16809759
10500157
16980581
17914104
|
EP300
|
CCND1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
17306568
17666529
11788592
23343194
21285352
15576399
21151179
22761862
22290435
16039586
19619488
19623618
17143292
|
TCF7L2
|
CCND1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
10.0
|
1.0
|
Omnipath
|
17666529
23343194
21285352
18974774
22761862
22290435
16039586
19619488
19623618
17143292
|
CDKN1A
|
CCND1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
31.0
|
1.0
|
Omnipath
|
26203195
23443559
17145710
25416956
7478582
9837900
21988832
21516116
7777546
15232106
16082198
27107012
15695403
8657154
8242751
23007395
9106657
12383116
17556661
8756624
8662825
31515488
|
ESR1
|
CCND1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
8649771
11073968
16061635
9039267
|
MYC
|
CCND1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
8425218
15121849
2006410
17873522
21406394
12584560
17558397
20551172
15814658
16908182
|
CCND1
|
RB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
27.0
|
1.0
|
Omnipath
|
10498883
9315635
17303408
16236519
11520855
15279786
9190208
7575488
10385618
9736735
8490963
26225123
19237565
7736585
19075565
18590585
27507850
26121043
20068082
9425340
18786381
17660363
10778858
9380698
27430527
|
CCND1
|
RBL2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
16600870
10498883
10385618
9736735
12006580
|
MIF
|
CD74
|
â—¼ PHYSICAL_INTERACTION
|
|
|
10.0
|
1.0
|
ACSN
|
10878343
12782713
12803886
16181339
16283355
18490733
20861157
23390297
8195715
9637476
|
MIF
|
CD74
|
â—¼ PROTEIN_INTERACTION
|
|
|
10.0
|
1.0
|
ACSN
|
10878343
12782713
12803886
16181339
16283355
18490733
20861157
23390297
8195715
9637476
|
TNF
|
CD74
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
33.0
|
1.0
|
ACSN
|
10925299
11112697
11438547
11875494
12646658
12811837
1431106
14607933
14625680
15099563
15699106
16713974
17916596
18633355
19411070
20038811
20184663
20435894
21133840
21411734
21826665
22595692
22955274
23170255
23430059
23508573
23510023
23567181
23769623
24092389
24378531
26201938
8910423
|
MIF
|
CD74
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
26039541
12782713
|
RB1
|
CDKN1A
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
9.0
|
1.0
|
Reactome
|
10207050
9447971
24876129
31543423
11416152
11032757
9190208
30711375
10499802
|
FOXO3
|
CDKN1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
18312651
18005957
16908841
20671123
21249150
|
MYC
|
CDKN1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
41.0
|
1.0
|
Omnipath
|
15190211
14519204
15616584
12408868
19174556
21949397
10319992
12553001
16204065
12545156
20878079
21042278
21400515
20190815
16706751
23804320
15757889
10920185
19270520
16452181
12408820
15528212
22371483
12565816
17885207
12384701
11274368
19150257
20551174
15899785
21120446
15071503
15474507
22814619
12835716
12748190
16738884
15711923
18636159
|
HDAC1
|
CDKN1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
12665570
19182791
15130752
18210215
16287849
17172847
|
TP63
|
CDKN1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
15790310
10383130
21480565
12640112
20123734
17404570
16007146
16410722
15965232
12374749
17965458
21093383
23665236
9405685
|
ESR1
|
CDKN1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
15557281
16628468
20696891
16847062
12151347
11517191
15378598
11274368
16469747
17681750
20301197
22787161
23349794
|
TP73
|
CDKN1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
19.0
|
1.0
|
Omnipath
|
10435630
15790310
11172610
17611664
12934105
18421303
21245298
18418051
12841870
14614455
12639967
10207112
17700533
18644986
18951877
19067706
16193303
12676926
|
EP300
|
CDKN1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
10362258
15509808
21858218
22000024
21245169
|
MYC
|
CDKN1A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
11.0
|
1.0
|
Omnipath
|
15528212
9618481
12545156
17550342
10454538
15155580
11283613
10920185
11283614
|
FOXO3
|
CDKN1A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
15084259
19380174
21708191
15084260
21613825
17940099
11154281
|
MAPK14
|
CDKN1A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
23745637
12058028
|
CDKN1A
|
RB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
20.0
|
1.0
|
Omnipath
|
10498883
9315635
17303408
10486249
16236519
11520855
15279786
9190208
7575488
10385618
9736735
7736585
19075565
18590585
20068082
9425340
18786381
17660363
10778858
17556661
|
EP300
|
TP63
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
15965232
|
EP300
|
TP73
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
23.0
|
1.0
|
Omnipath
|
11804596
19407812
15175157
19788416
12660246
19218448
10648616
15454570
16998810
25675294
15893728
18663001
|
EP300
|
SMAD1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
12419246
14500836
10673036
22298955
|
EP300
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
19.0
|
1.0
|
Omnipath
|
17145710
22290435
19623618
11804596
23343194
22761862
16039586
12776737
17157259
17143292
12660246
15576399
21151179
15522869
17306568
19407812
17666529
21285352
19619488
|
FOXO3
|
ESR1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
24062311
16807346
16809346
17575143
|
FOXO3
|
BTG1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
14734530
18226221
|
MAPK14
|
FOXO3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
22128155
23857333
|
FOXO3
|
ESR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
11435445
15367686
16807346
18312651
|
NCF1
|
MAPK14
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
16778989
25877926
14530365
27558335
|
MAPK14
|
NFKBIA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
14580335
16410802
8622692
8668171
9724653
|
MAPK14
|
HBP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
14612426
|
MAPK14
|
RB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
20.0
|
1.0
|
Omnipath
|
11439341
17599043
9190208
15355984
17380128
22279936
27642049
33419772
1756735
17996702
17570479
22895174
20871633
20223825
33219128
|
MAPK14
|
ESR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
23216744
22431515
12138194
15879307
|
MAPK14
|
CASP8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
14970175
|
TNF
|
MIF
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
52.0
|
1.0
|
ACSN
|
10754326
10878343
10925299
10952726
11112697
11438547
11875494
12646658
12782713
12803886
12811837
12907458
1431106
14607933
14625680
14660645
15099563
15465827
15644117
15699106
16283355
16713974
16878026
17404308
17485448
17916596
18490733
18633355
19411070
20038811
20184663
20435894
20861157
21133840
21411734
21826665
22595692
22955274
23170255
23390297
23430059
23508573
23510023
23567181
23769623
24092389
24378531
26201938
7594497
8195715
8910423
9637476
|
TNF
|
MIF
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
52.0
|
1.0
|
ACSN
|
10754326
10878343
10925299
10952726
11112697
11438547
11875494
12646658
12782713
12803886
12811837
12907458
1431106
14607933
14625680
14660645
15099563
15465827
15644117
15699106
16283355
16713974
16878026
17404308
17485448
17916596
18490733
18633355
19411070
20038811
20184663
20435894
20861157
21133840
21411734
21826665
22595692
22955274
23170255
23390297
23430059
23508573
23510023
23567181
23769623
24092389
24378531
26201938
7594497
8195715
8910423
9637476
|
TCF7L2
|
MYC
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
20.0
|
1.0
|
Omnipath
|
12095419
19561604
19895682
15579438
26947016
16204248
12799378
12907606
17360646
9727977
21533051
20133699
15576399
19784072
24447505
12591729
20818421
18852287
11973610
|
ESR1
|
MYC
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
22396492
21835891
15073177
18193094
11517191
21505052
22892083
8707895
19569049
14722073
18414489
|
MYC
|
CASP8
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
15367674
12695333
|
MYC
|
IL2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
8962093
10702306
12695333
1349016
9417120
|
CREBBP
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
10.0
|
1.0
|
Omnipath
|
7575488
18590585
17303408
15522869
12776737
20144767
17660363
16878156
15279786
|
HBP1
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
20008325
|
HDAC1
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
21734722
17666529
15576399
22761862
22290435
19923891
20682799
|
TCF7L2
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
17306568
17666529
23343194
21285352
15576399
21151179
22761862
22290435
16039586
19619488
19623618
17143292
|
HDAC1
|
TNF
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
15.0
|
1.0
|
ACSN
|
10754326
10952726
11875494
12907458
14660645
14668329
15465827
15644117
16878026
17404308
17485448
21234400
22796940
23390297
7594497
|
ESR1
|
TNF
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
23733894
15334655
16483936
12237295
20664923
|
TNF
|
IRS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
20.0
|
1.0
|
Omnipath
|
22328823
22869320
19808894
12110133
11160134
12409308
22266116
21478880
11684411
25352752
24966659
29425748
16754954
25355439
22823902
18443205
24648009
26976796
25645159
23592917
|
TNF
|
NFKBIA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
11.0
|
1.0
|
Omnipath
|
19053972
24083678
25215581
29088783
24386331
25888769
20460401
16866128
19934328
9363938
24349153
|
TP73
|
CREBBP
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
10648616
21245298
11172610
10435630
|
HDAC1
|
TCF7L2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
10485845
11266540
10559189
20405012
|
HDAC1
|
SIN3A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
27.0
|
1.0
|
ACSN
|
11283614
12545156
12668723
14673164
15151915
15155580
15465827
16232121
17018611
17055429
17508028
17550342
17563753
20027199
20713526
20818389
21234400
21577210
21733352
2191300
21919891
22370643
22514743
22796940
23140366
23869868
9618481
|
HDAC1
|
SIN3A
|
â—¼ SHARES_COMPLEX
|
|
|
27.0
|
1.0
|
ACSN
|
11283614
12545156
12668723
14673164
15151915
15155580
15465827
16232121
17018611
17055429
17508028
17550342
17563753
20027199
20713526
20818389
21234400
21577210
21733352
2191300
21919891
22370643
22514743
22796940
23140366
23869868
9618481
|
HDAC1
|
SIN3A
|
â—¼ UP_REGULATES
|
✅
|
+
|
27.0
|
1.0
|
ACSN
|
11283614
12545156
12668723
14673164
15151915
15155580
15465827
16232121
17018611
17055429
17508028
17550342
17563753
20027199
20713526
20818389
21234400
21577210
21733352
2191300
21919891
22370643
22514743
22796940
23140366
23869868
9618481
|
HDAC1
|
ESR1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
21655924
23242655
18316616
20101232
|
NCF1
|
MAPK11
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
16778989
25877926
14530365
27558335
|
RUNX1
|
IL2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
17466384
22253733
17377532
21292764
|
CREBBP
|
TCF7L2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
10769018
11050151
18160704
15060161
11973335
10775268
|
CREBBP
|
ESR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
9192902
18765668
16417649
11113179
8616895
11782371
14766010
17400812
|
SMAD1
|
BMP2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
14551209
11786386
21471203
19836350
11585340
22072987
|
MAPK11
|
HBP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
14612426
|