FOXO3
|
FOXP3
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20439537
20467422
|
NFATC2
|
MYC
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23858296
22333584
|
MYC
|
HDAC2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20697349
|
NFATC2
|
FOXP3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
17377532
16873067
|
NFATC2
|
IL2RA
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17463169
9763616
|
NFATC2
|
NFATC1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19564342
11786533
|
IL2RA
|
IL2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
0607058103
17032757
|
IKZF3
|
IL2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20676092
22751139
|
FOXP3
|
NFATC1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
20554955
19564342
|
FOXP3
|
IKZF2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20554955
19797626
|
IKZF2
|
IKZF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16189514
9560339
|
NFATC1
|
IL2RA
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19564342
9763616
|
MYC
|
CTBP2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
30415952
29467282
|
IKZF3
|
HDAC2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
12015313
30760870
|
SIN3B
|
SIN3A
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
33961781
26496610
|
IKZF3
|
CHD4
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
12015313
30760870
|
HDAC4
|
SIN3A
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
17011572
10220385
17210713
|
HDAC2
|
FOXP3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
19276356
25609649
|
SIN3B
|
IKZF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
10357820
12015313
|
IKZF5
|
IKZF2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
28514442
16189514
33961781
10978333
|
FOXP3
|
IL2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
848.0
|
0.84
|
STRING
|
36370105
|
MYC
|
SIN3B
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
24951594
30415952
|
HDAC2
|
IKZF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
10204490
10357820
30760870
12015313
|
SIN3A
|
IKZF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
10357820
11959865
12015313
|
IL2RA
|
IL2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
17032757
16477002
1993646
|
MYC
|
HDAC2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
17314511
20195357
22286234
30415952
|
IKZF1
|
CTBP2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
28514442
32296183
25416956
33961781
21516116
|
IKZF1
|
CHD4
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
28514442
30760870
11003653
12015313
33961781
|
CHD4
|
IKZF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
870.0
|
0.87
|
STRING
|
36370105
|
HDAC2
|
IKZF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
876.0
|
0.87
|
STRING
|
36370105
|
HDAC2
|
SIN3B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
878.0
|
0.87
|
STRING
|
36370105
|
HDAC1
|
CHD4
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.88
|
0.88
|
mint
|
26949739
|
IKZF1
|
HDAC1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
23752268
16189514
30760870
10357820
12015313
10204490
|
IKZF2
|
IKZF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
9560339
16189514
33961781
28514442
|
IKZF1
|
IKZF3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
28514442
9155026
26823144
33961781
10204490
|
MYC
|
CHD4
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
17314511
30415952
29467282
|
HDAC2
|
SIN3B
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
15935060
26949739
21258344
24981860
16464847
|
MYC
|
HDAC1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
17314511
18271930
34147029
26496610
30415952
18003922
22286234
24951594
|
NFATC2
|
FOXP3
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
25126782
16517728
17463169
|
CHD4
|
HDAC1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
28514442
25247294
32744500
21258344
11102443
28977666
9885572
26496610
20585571
10220385
22075476
21670149
22939629
23752268
27616479
9790534
9804427
26949739
20693977
33961781
24981860
12920132
26344197
|
SIN3A
|
HDAC1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
15695521
28514442
9520398
10640275
14647463
12398767
9150133
10444591
14593184
21258344
12943729
12374985
17956988
11102443
9885572
17962807
26496610
12453419
11171972
16331260
20585571
10220385
25314079
12091390
11931768
17643391
11602581
17827154
12724404
11784859
23752268
18059533
9790534
9804427
26949739
24981860
33961781
19182791
11118440
15451426
12920132
26344197
|
HDAC1
|
SIN3B
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
28514442
23752268
11959842
20585571
10357820
15935060
10444591
26496610
33961781
11102443
24951594
26344197
|
HDAC2
|
CHD4
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
23752268
9790534
9804427
11003653
22939629
30737378
28977666
26949739
32744500
21258344
24981860
21670149
12493763
9885572
10545197
26344197
|
IKZF1
|
LNPEP
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
11798181
15894523
16364975
|
IKZF1
|
IKZF5
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
28514442
10978333
30217970
33961781
27107012
|
IKZF1
|
IKZF3
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
17383641
|
IKZF5
|
IKZF3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
28514442
16189514
25416956
10978333
33961781
|
CHD4
|
HDAC2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
936.0
|
0.93
|
STRING
|
36370105
|
HDAC2
|
HDAC1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.94
|
0.94
|
mint
|
26949739
|
FOXP3
|
NFATC2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
941.0
|
0.94
|
STRING
|
36370105
|
CHD4
|
HDAC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
943.0
|
0.94
|
STRING
|
36370105
|
HDAC1
|
SIN3B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
961.0
|
0.96
|
STRING
|
36370105
|
HDAC2
|
HDAC1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
28514442
25241761
9520398
11287668
19703393
30737378
17894944
10444591
11466315
11777905
21258344
15297431
17956988
11102443
9885572
12032298
19041848
26496610
22416134
12493763
11739383
10581039
11804585
11564889
21670149
22939629
9150135
11919195
23752268
18059533
16713569
9804427
20388487
9790534
26949739
24981860
33961781
15987735
19182791
15451426
12920132
26344197
|
SIN3A
|
HDAC2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
16254079
12398767
21258344
12943729
9885572
9150134
12453419
12493763
14749338
22493095
12082111
25314079
12091390
17827154
12724404
23752268
18059533
9804427
26949739
24981860
15451426
26344197
|
MYC
|
IL2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
8962093
10702306
12695333
1349016
9417120
|
HDAC1
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
21734722
17666529
15576399
22761862
22290435
19923891
20682799
|
NFATC2
|
IL2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
25.0
|
1.0
|
Omnipath
|
15180435
20557936
8576111
8014029
8397339
7706710
21458306
21832163
8577772
17513763
16873067
8631809
11956291
12560487
17237447
24561192
18097033
7565732
8668213
7982959
21799768
8441422
9047239
8098881
1712901
|
NFATC1
|
NFATC2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
19915002
18078995
15657420
18299389
16455648
11402342
11030334
|
HDAC1
|
HDAC2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
28.0
|
1.0
|
ACSN
|
11283614
12545156
12668723
14673164
15151915
15155580
15465827
16232121
17018611
17055429
17508028
17550342
17563753
20027199
20713526
20818389
21234400
21577210
21685935
21733352
2191300
21919891
22370643
22514743
22796940
23140366
23869868
9618481
|
HDAC1
|
SIN3A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
27.0
|
1.0
|
ACSN
|
11283614
12545156
12668723
14673164
15151915
15155580
15465827
16232121
17018611
17055429
17508028
17550342
17563753
20027199
20713526
20818389
21234400
21577210
21733352
2191300
21919891
22370643
22514743
22796940
23140366
23869868
9618481
|
HDAC1
|
HDAC2
|
â—¼ SHARES_COMPLEX
|
|
|
28.0
|
1.0
|
ACSN
|
11283614
12545156
12668723
14673164
15151915
15155580
15465827
16232121
17018611
17055429
17508028
17550342
17563753
20027199
20713526
20818389
21234400
21577210
21685935
21733352
2191300
21919891
22370643
22514743
22796940
23140366
23869868
9618481
|
HDAC1
|
SIN3A
|
â—¼ SHARES_COMPLEX
|
|
|
27.0
|
1.0
|
ACSN
|
11283614
12545156
12668723
14673164
15151915
15155580
15465827
16232121
17018611
17055429
17508028
17550342
17563753
20027199
20713526
20818389
21234400
21577210
21733352
2191300
21919891
22370643
22514743
22796940
23140366
23869868
9618481
|
HDAC1
|
SIN3A
|
â—¼ UP_REGULATES
|
✅
|
+
|
27.0
|
1.0
|
ACSN
|
11283614
12545156
12668723
14673164
15151915
15155580
15465827
16232121
17018611
17055429
17508028
17550342
17563753
20027199
20713526
20818389
21234400
21577210
21733352
2191300
21919891
22370643
22514743
22796940
23140366
23869868
9618481
|
HDAC1
|
HDAC2
|
â—¼ UP_REGULATES
|
✅
|
+
|
28.0
|
1.0
|
ACSN
|
11283614
12545156
12668723
14673164
15151915
15155580
15465827
16232121
17018611
17055429
17508028
17550342
17563753
20027199
20713526
20818389
21234400
21577210
21685935
21733352
2191300
21919891
22370643
22514743
22796940
23140366
23869868
9618481
|
HDAC2
|
SIN3A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
8.0
|
1.0
|
ACSN
|
14673164
15465827
17018611
17563753
21234400
21577210
22514743
22796940
|
HDAC2
|
SIN3A
|
â—¼ SHARES_COMPLEX
|
|
|
8.0
|
1.0
|
ACSN
|
14673164
15465827
17018611
17563753
21234400
21577210
22514743
22796940
|
IL2
|
IL2RA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
26.0
|
1.0
|
ACSN
|
10807786
10820393
10849428
12095053
15289500
15563472
16212621
16799562
17371980
1825141
18758473
19528259
19833085
20856220
21840487
22224781
23124025
23650441
24829413
26755705
2965306
6164929
7512720
7521688
8683106
9625766
|
IL2
|
IL2RA
|
â—¼ SHARES_COMPLEX
|
|
|
26.0
|
1.0
|
ACSN
|
10807786
10820393
10849428
12095053
15289500
15563472
16212621
16799562
17371980
1825141
18758473
19528259
19833085
20856220
21840487
22224781
23124025
23650441
24829413
26755705
2965306
6164929
7512720
7521688
8683106
9625766
|
IKZF1
|
IL2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
17148585
18025173
19828627
22684523
24328678
|
FOXP3
|
IL2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
22.0
|
1.0
|
Omnipath
|
25567984
23275607
22806628
21458306
17028180
16873067
21955384
17586580
23954131
17922010
20429413
18324310
19172156
17416586
22579476
18779564
17430097
21654845
17632414
11483607
18759924
19564342
|
NFATC1
|
IL2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
21.0
|
1.0
|
Omnipath
|
16498406
20557936
17179947
21832163
15005855
17513763
7730629
8631809
10656874
12560487
8202141
18097033
9756940
8543769
8660843
7739550
23924068
15347678
19564342
19181930
18769450
|
NFATC1
|
IL2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
17928811
16406523
19218564
20452955
|
IL2
|
IL2RA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
25.0
|
1.0
|
Omnipath
|
6815536
3095922
15265897
12649439
16477002
15933202
1940342
17032757
15178252
8260650
3116143
8894436
1993646
8580082
8960125
|
FOXP3
|
IL2RA
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
ACSN
|
12522256
17237765
17449799
21411734
|
FOXP3
|
IL2RA
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
23144749
20554955
17028180
18606654
15466453
21036387
|