Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
HIF1A BCL2L1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17558861 19211554
CDK1 BCL2L1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19917720
CDK1 BCL2L11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17570479 22071694
ATF4 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18729081 20101207
EGFR CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7945309
KLB CCT2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
CDC37 SQSTM1 â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 21900206 2001699 8089645
MAPK1 CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17205132
STAT1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17992189
IRS1 EGFR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
NUMB EGFR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
EGFR ATP5F1C â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
EGFR IRS4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
AREG EGFR â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 20430953 23010081
STAT1 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10558875 22693070
MAPK3 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24530506
EP300 FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11896584
FOXO3 HIF1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18268343 0706790105
FOXO3 CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12391153 15509806
FOXO3 TSC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20371605
FOXO3 JAK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12351634
PRKAB1 FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21329882 17711846
GRB2 RPS9 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 EIF3D â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
MAPK3 GRB2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7739560 8816480
MAPK1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8994038
HSP90AA1 HIF1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18538669 6550889
HIF1A HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14726529 20068160
HSP90AA1 DAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16551624
TSC1 KDM1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 23455924 8417751
HIF1A KDM1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 32938217
KDM1A ACTB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16140033
FGF2 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9490736 12750158
MAPK1 MAP2K3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 16709866
MAPK14 FKBP8 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
MAP2K3 MAPK14 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8622669 7535770
MAPK3 SQSTM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7717053 20154642
MAPK3 IRS2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7739560 8816480
MAPK3 IRS1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7739560 8816480
EGF MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17081983 16024629
HIF1A MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12606552 15385570
MTOR PDPK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5214238 11438723
EIF4E MTOR â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12150926 15809305
MTOR EIF4EBP1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12150926 15809305
MTOR CLIP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12231510
MTOR RRN3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23993916 25679014
MTOR EIF3F â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16541103
RRAGD RPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20006481 18497260
SQSTM1 ATXN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SQSTM1 PRKAG2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ATF4 FGF21 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22233381
ATXN1 CDK6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
EIF3M EIF3F â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
ATXN1 EIF3F â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
EIF3H EIF3F â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18599441 0801313105
PPARGC1A PRKAA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17609368 0705070104
PRKAA2 PRKAG3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16943194 8549768
PRKAA2 PPARGC1A â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 21451146 19112161
EIF3M EIF3H â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18599441 0801313105
ATXN1 ATP5F1B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PRKAG1 EIF3G â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8153045 21516116
EIF3I EIF3G â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219314 17094969
TSC2 DAPK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8057025 21134130
TSC2 TSC1 â—¼   COLOCALIZATION 2.0 0.8 intact 6547838 9580671
TSC2 MAPKAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18411301 29497474
IL4R STAT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15261459 23124025
IL6 STAT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8662591 8662795
STAT1 IL2RA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10068671 12244150
STAT1 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19646959
IL2RA JAK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15178252 16477002
JAK1 ERBB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
ERBB2 JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16273093
ITGA4 ITGB7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 12626562 19454690
ITGA4 ITGB7 â—¼   PROTEIN_INTERACTION 2.0 0.8 ACSN 12626562 19454690
ITGA6 ITGB4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 19161977 22118458
ITGA6 ITGB4 â—¼   PROTEIN_INTERACTION 2.0 0.8 ACSN 19161977 22118458
PRKAG1 PPARGC1A â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 21451146 19112161
PRKAB2 PPARGC1A â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 21451146 19112161
PPARGC1A PRKAG3 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 21451146 19112161
PPARGC1A PRKAB1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 21451146 19112161
PPARGC1A PRKAG2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 21451146 19112161
PPARGC1A CPT1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19233164 15199055
DAPK1 PRKAG2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29513927 201700444
LARP1 YWHAB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
IRS2 YWHAB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
A2M FZD4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HIF1A ITGB3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19828020 23640055
HIF1A FLT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16601206 15192019
TSC1 EIF3A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
GSK3B TSC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15972957 16959574
RB1CC1 TSC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16043512
AKT2 TSC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12150915 12172553
FGF2 FGF9 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18552176 18757403
INS IRS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9609109 15316008
IRS1 IRS4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 11912194
CDK4 CCND2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
INS IRS2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9609109 15316008
ATG10 GNB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CHRM1 GNB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14976183 8196770
LAMTOR2 ATP6V1B2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 25567906 1257132
EIF3L EIF3E â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18599441 0801313105
EIF3K EIF3E â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18599441 0801313105
EIF3E EIF3B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18599441 0801313105
EIF3L EIF3K â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
EIF3K EIF3B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18599441 0801313105
EIF3L EIF3B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18599441 0801313105
EIF3M EIF3B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18599441 0801313105
LAMTOR2 LAMP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 25567906 1257132
RRAGC RRAGA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
ERBB2 IRS4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
ATG10 ATXN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ITGB4 ATXN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
ATXN1 ATP5PB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PRKAB1 PRKAA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6767403 18480843
PRKAB1 ULK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21460634 21072212
IL7 JAK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8128231 8266077
IL2RA JAK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15178252 16477002
ATP5F1E ATP5F1C â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
MLST8 RRAGC â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
MLST8 RRAGA â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
CCND1 CDK1 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
IRS1 YWHAB â—¼   PHYSICAL_INTERACTION 806.0 0.8 STRING 36370105
IRS1 RPTOR â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 16354680 19561084 30240640
EIF3F EIF3B â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 24396066
EIF3F RPS9 â—¼   PHYSICAL_INTERACTION 810.0 0.81 STRING 36370105
COX6C COX7B â—¼   PHYSICAL_INTERACTION 815.0 0.81 STRING 36370105
COX7B COX7C â—¼   PHYSICAL_INTERACTION 818.0 0.81 STRING 36370105
EIF3H RPS9 â—¼   PHYSICAL_INTERACTION 818.0 0.81 STRING 36370105
EIF3D RPS9 â—¼   PHYSICAL_INTERACTION 818.0 0.81 STRING 36370105
ULK1 CDC37 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21855797 20562859
CDC37 ERBB2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 25036637 24189400
CDC37 CDK1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17525741 25036637
CDC37 PDPK1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 25036637 31980649
CDK2 CDK1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 21319273
IRS4 EGFR â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 24797263 16273093
NUMB EGFR â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 16273093 25754235
EGFR ACTB â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22366308 31980649
ACTB EP300 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33742100 21988832
EIF3B RPTOR â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21045808 16286006
BRAF RPTOR â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 31980649
COX6C COX7C â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31536960 33961781
CDK4 JAK3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 26186194
LPIN3 LPIN2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
IFNA4 IFNA7 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
TSC2 MTOR â—¼   DOWN_REGULATES ✅ - 0.82 0.82 Signor 12271141
CCND1 CDK1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 26496610 33961781 7903056 21654808
EGFR EPHA2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 24797263 15657067
ACTB MDM2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 24583282 24798327 17373842
PRR5L MTOR â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 17461779 18030348
EIF3B MTOR â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 21045808 18423201 16286006
AREG ADCY9 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
TSC1 RHEB â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 12820960 30514904
EIF3C EIF3J â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 23623729 15946946 9822659
EIF3J EIF3I â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 14688252 33961781 26186194
RHEB TSC1 â—¼   PHYSICAL_INTERACTION 834.0 0.83 STRING 36370105
ATG13 C9orf72 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
CCND1 EP300 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
RPTOR ULK1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
C9orf72 ULK1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
BRAF MAPK1 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
FOXO3 EP300 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 19592618 25609649 11896584
ERBB2 EPHA2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 30898150 28628118 28205554
GRB2 IRS2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 7559579 22974441 9852124 21706016
STAT1 MTOR â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 19553685 25241761 12807916
EIF3F MTOR â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 32131492 16541103
ULK1 RPTOR â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 25686248 21795849 21460634 21460630
EIF3F EIF3J â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 23623729 19615732
PDPK1 FGF2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 32707033 31980649
FOXO3 MDM2 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
MTOR ULK1 â—¼   PHOSPHORYLATION ✅ - 0.84 0.84 Signor 21460634
EIF3E RPS9 â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
EIF3L RPS9 â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
CDKN1A EP300 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
ATP6V1D ATP6V1G2 â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
EIF3J EIF3L â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
GSK3B CDC37 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 23455922 29568061 33961781
MDM2 ATF4 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 27264869 21988832
RHEB MTOR â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 18550814 16098514 16915281 15854902 33157014 15772076 15878852 25351248
RPTOR RRAGA â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 28514442 18497260 31601708 23184942 21816923 26582740 33961781 26186194 31601764 33157014 25561175 24337580
EIF3K EIF3J â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 23623729 14519125
ERBB2 GRB2 â—¼   RELOCALIZATION ✅ + 0.85 0.85 Signor 14967450
COX6C COX7C â—¼   PHYSICAL_INTERACTION 856.0 0.85 STRING 36370105
RPTOR RRAGD â—¼   PHYSICAL_INTERACTION 857.0 0.85 STRING 36370105
TSC2 CCND1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16357142 26977878
ATF4 EP300 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 14630807 17872950 10350644 12471036 16219772
IRS4 GRB2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 21706016 9553137
PRR5 MTOR â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 17461779 18505677
MTOR MAPKAP1 â—¼   COLOCALIZATION ✅ 0.86 0.86 mint 21045808 8088164
RPTOR RRAGC â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 25567906 21981924 18497260 31601708 21816923 25446900 31601764 25561175 24337580
EIF3G EIF3B â—¼   PHYSICAL_INTERACTION ✅ 0.86 0.86 mint 24396066
TSC2 GSK3B â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16959574 12511557
JAK1 STAT1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 32123171 11722592 34521819 32953130 11294897 10982844 15322115 12637327 7690989 14978237 15284024 10918587 7543024 32814877 12817007 34950606 7657660 11839738
EIF3B EIF3A â—¼   PHYSICAL_INTERACTION ✅ 0.86 0.86 mint 19245811 6948825
ULK1 RB1CC1 â—¼   PHYSICAL_INTERACTION ✅ 0.86 0.86 mint 8428476 23392225
ATG13 RB1CC1 â—¼   PHYSICAL_INTERACTION 861.0 0.86 STRING 36370105
ATG101 ULK1 â—¼   PHYSICAL_INTERACTION 861.0 0.86 STRING 36370105
EIF3C RPS9 â—¼   PHYSICAL_INTERACTION 866.0 0.86 STRING 36370105
EIF4EBP1 MLST8 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
BRAF CDC37 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 27034005 31980649 17979178 33961781 27684187
CCND2 CDK2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 9840943 28514442 33854235 33961781 26186194 23455922 9178893
ULK1 MTOR â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 25686248 23524951 29321306 21460630
EIF3F EIF3A â—¼   PHYSICAL_INTERACTION ✅ 0.87 0.87 mint 24396066
WDR5 PDPK1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 33961781 26186194 27705803
EIF3H EIF3J â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 23623729 19615732
EIF3G EIF3M â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 17403899 33961781 24981860 26186194 22939629
EIF3G EIF3L â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 33961781 24981860 26186194 22939629 26344197
EIF3I EIF3M â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 17403899 33961781 24981860 26186194 22939629
EIF3I EIF3L â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 33961781 24981860 26186194 22939629
CDK6 CDKN1A â—¼   PHOSPHORYLATION ✅ - 0.87 0.87 Signor 16508017
GABARAPL1 SQSTM1 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
CDKN1A MDM2 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
EP300 STAT1 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
EIF3G RPS9 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
EIF3J RPS9 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
EIF3B RPS9 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
EIF3B EIF4E â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
EP300 MDM2 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
MAPK1 MAPK14 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
HIF1A MDM2 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
EIF3I RPS9 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
EGFR STAT1 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
EP300 CCND1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 15951563 10567390 11788592
FKBP8 EGFR â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 20029029 31980649
JAK1 GRB2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 11527382 8536716
RRAGD RPTOR â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 26582740 24337580 18497260 22424946
CDK4 CDK6 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 23455922 28205554 28628118 33961781
EIF3D EIF3M â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 17403899 22190034 33961781 24981860 26186194 23623729 22939629 26344197
EIF3E EIF3M â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 17403899 33961781 24981860 26186194 23623729 22939629 26344197
EIF3K EIF3M â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 17403899 33961781 24981860 26186194 23623729 22939629 26344197
EIF3L EIF3M â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 17403899 33961781 24981860 26186194 23623729 22939629 26344197
PRKAA1 PRKAG3 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
EGFR HSP90AA1 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
MAPK1 MAPK3 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
EIF3D EIF3J â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
ATG13 ATG101 â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 8428476 23392225
ULK1 ATG13 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 27617292 32543267 32668203 23524951 25686248 33450483 20562859 25126726 29196462 18936157 19597335 21460634 23392225 26018823 33499712 32707033 27203176 33422265 30853401 21460630
EGFR CDC37 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 25036637 31980649 12471035 24189400 23956138
CDK4 HSP90AA1 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
RPTOR RRAGB â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
EIF3F EIF3L â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 31527668 33961781 26186194 23623729 22939629 19615732 26344197
EIF3H EIF3L â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 32269044 22863883 33961781 24981860 26186194 23623729 22939629 19615732 26344197
YWHAB BRAF â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 5217174 15324660
EIF3B EIF3J â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 14688252 15946946 18628297
EIF3C EIF3L â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 18599441 22863883 33961781 24981860 23623729 22939629 26344197
EIF3C EIF3M â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 18599441 17403899 33961781 24981860 26186194 23623729 22939629 26344197
EIF3B EIF3L â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 18599441 28514442 33961781 24981860 22939629 26344197
EIF3B EIF3M â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 18599441 28514442 17403899 33961781 24981860 26186194 22939629 26344197
RRAGA RRAGD â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 16189514 26582740 33961781 26186194 28716898 11073942 25561175 22424946
PRKAG1 PRKAB1 â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 18480843 6767403
EIF3J EIF3M â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
TSC2 YWHAB â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
MDM2 NUMB â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
EIF3F EIF3J â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
LARP1 BCL2L1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
ACTB BCL2L1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
MAPK14 BCL2L11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15486195 17570479 16818494
CCND1 CDK2 â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
FOXO3 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12391153 21294163
CDC37 MTOR â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CDC37 CDK4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 23455922 28514442 8703009 21871133 25036637 11867521 9150368 24189400 17353931 24292678 8666233 33961781 24981860 26186194 32707033 27339980 21675959
CDC37 CDK6 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 25036637 24292678 9150368 8666233 33961781
EGFR CDK1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31980649 23956138 24658140 25402006 18271526 15657067
CDK2 EP300 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 33961781 26186194 10330164 23455922
HSP90AA1 CDKN1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15664193 9844631 20018861
A2M CDKN1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
ATP5F1B CDKN1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
ACTB CDKN1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
GNB2 CDKN1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CDKN1A ANGPT2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CDKN1A COL4A5 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
EGFR STAT1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 24797263 31980649 23956138 11294897 15322115 24658140 12637327 7690989 15284024 10918587 25402006 7543024 12070153 12817007 10358079 7657660 11839738
EGFR ERBB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11500850 25241761 30898150 17486068 11526509 9461599 23866081 17426253 10572067 11500516 24557338 8665853 15657067 19060928 16516204 19650109 20211985 25315821 23436906 21278786 25898135 32669362 1346931 24189400 21044682 18803307 16843263 28369073 7531698 16713569 17148612 21203579 17307140 1706616 16207817 7797556 12354693 11408594
EGFR AREG â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16713569 28988771 10085134 8663535
EGFR JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8524316 15284024
EP300 MDM2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15154850 20234175 16713569 11070080 9809062 28196907 15013777
MDM2 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9809062 11070080 16713569
FOXO3 PRKAA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24257750 22848740 17711846
MAPK3 FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19282669
ITGB3 GRB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12005431 9566877 7997267
IRS2 GRB2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 19109239 7890616 9535722
FN1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18624398 19738201
JAK1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8536716 11527382
IRS4 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9553137 15316024
MAPK1 YWHAB â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 27503831 16939974 9560161
BRAF MAPK1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16508002 14654779 19933846
MAPK1 MAP2K2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 10567369 19219045 8013650
LAMTOR3 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11266467 9733512
MAPK1 TSC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15851026 17671177
MAPK1 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18378670 7569900 14963018
BRAF MAPK3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 27503831 16939974 9560161
MAPK3 YWHAB â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 27503831 16939974 9560161
BRAF MAPK3 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16508002 14654779 19933846
MAPK3 MAP2K2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 10567369 19219045 8013650
MAP2K3 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8226933
FGF2 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9490736 29436393 12750158
HIF1A MDM2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12606552 10640274 25447306 15880652 19696166 25535359 17234751 15385570
NUMB MDM2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31533005 18172499 12646252 23252402 9632782 29269425 28223335 22337874 31451549 27106262 16678796
GSK3B MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16055726 18505846
MTOR GSK3B â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
MTOR RPTOR â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16847060 26522726 12604610 19619545 26348909 33378666 20169205 24036451 18570873 24516643 19299511 34031390 22424946 22356909 25940091 12719976 22544753 23263282 12150926 12665511 18505677 17277771 17461779 22493283 19114562 18722121 21071439 18030348 19446321 12718876 12747827 24375676 22258093 16837165 21045808 16962653 18955708 17565979 12408816 15467718 23953116 27043084 23911927 17043309 31601708 21177249 21614075 21795849 16631613 20381137 21321085 23297343 23872070 16354680 19875983 25446900 29059166 24337580 16603397 16183647 34171383 15066126 24403073 25332233 17386266 19145465 25007995 16798736 26678875 15268862 20427287 30865892 16919458 25273559 15459249 18519641 18504440 12150925
PRKAA1 MTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 14970221
RHEB RPTOR â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16631613 25446900 15854902 33157014 24337580
AKT2 RPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17517883 18372248 17277771
CDK6 CCND2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 16713569 28628118 10022865 28205554 11360184 30217970 33961781 23602568 11358847 9178893
EIF3F EIF3M â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 18599441 28514442 25416956 32296183 17403899 23623729 31527668 22863883 33961781 24981860 26186194 16169070 19748344 22939629 19615732 26344197
EIF3H EIF3M â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 18599441 28514442 17403899 32867821 33961781 24981860 26186194 23623729 22939629 19615732 26344197
CDK4 ATP5F1B â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
AREG ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7679104 23331499
RHEB TSC2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12869586 12820960 30514904 12842888 17077083 15854902 12771962
EGF STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 28542650 19168569 22162832
MAPK9 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14963018
PDPK1 MAP3K7 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 17496917 15125833 16056267
IL6 JAK1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 8134389 8272873 9382798
FN1 ITGA4 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 20644254 22067905 24202395
LAMC1 ITGA6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11964076 16413178 16581764
AKT1S1 YWHAB â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 8008321 18372248 800723200
HIF1A ANGPT2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16338068 12958144 19491109
PDPK1 AKT2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 9228007 9094314 15890450
FN1 ITGB8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7542940
GSK3B GNB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
GNGT2 GNB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8636150 19168127 19376773
EIF3J EIF3A â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 18599441 23623729 9822659 14519125
EIF3A EIF3L â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 18599441 17353931 11590142 22863883 33961781 24981860 23623729 22939629 26344197
EIF3A EIF3M â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 18599441 17403899 17353931 33961781 24981860 26186194 23623729 22939629
ATG4B MAP1LC3C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20562859 32296183 15187094
EIF3L EIF3D â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 18599441 22190034 11590142 22863883 33961781 24981860 23623729 22939629 26344197
EIF3L EIF3E â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 18599441 28514442 16189514 17403899 23623729 11590142 22863883 33961781 24981860 19748344 22939629 26344197
AKT2 BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10869359
EIF4EBP1 GSK3B â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
GSK3B CAMKK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 22778263
LAMC1 ITGB4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11964076 16413178 16581764
CDK6 CDKN1A â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
EIF3E EIF3J â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
EIF3J EIF3K â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
PRKAA2 PRKAB1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HuRI 32296183
ACTB CDC37 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HuRI 32296183
CCND2 CDK2 â—¼   PHYSICAL_INTERACTION 903.0 0.9 STRING 36370105
MTOR AKT1S1 â—¼   PHOSPHORYLATION ✅ - 0.9 0.9 Signor 18372248
ULK1 RB1CC1 â—¼   PHOSPHORYLATION ✅ + 0.9 0.9 Signor 19597335
TSC1 RHEB â—¼   PHYSICAL_INTERACTION ✅ - 0.9 0.9 Signor 20006481
ERBB2 HSP90AA1 â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
ULK1 ATG13 â—¼   PHOSPHORYLATION ✅ + 0.91 0.91 Signor 19211835
CDK1 CDKN1A â—¼   PHYSICAL_INTERACTION 909.0 0.91 STRING 36370105
PRKAB2 PRKAG3 â—¼   PHYSICAL_INTERACTION 909.0 0.91 STRING 36370105
CCND2 CDKN1A â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
EIF3A RPS9 â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
GRB2 IRS1 â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
LAMTOR4 MTOR â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
RRAGA RRAGB â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
RRAGD SLC38A9 â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
TSC2 RHEB â—¼   GTPASE_REACTION ✅ - 0.91 0.91 Signor 15340059
LAMTOR4 RRAGD â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
PRKAB1 PRKAG3 â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
CCND1 CDK6 â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
GRB2 ERBB2 â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 16273093 5218056
HIF1A HSP90AA1 â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
ATP6V1B2 RRAGC â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
EGFR GRB2 â—¼   PHOSPHORYLATION 0.92 0.92 Signor 11726515
EIF3H EIF3J â—¼   PHYSICAL_INTERACTION 922.0 0.92 STRING 36370105
MAP2K2 MAPK3 â—¼   PHYSICAL_INTERACTION 924.0 0.92 STRING 36370105
MAP2K3 MAPK14 â—¼   PHYSICAL_INTERACTION 928.0 0.92 STRING 36370105
ULK1 ATG13 â—¼   PHYSICAL_INTERACTION ✅ 0.93 0.93 mint 8428476 23392225
CDK4 CDC37 â—¼   PHYSICAL_INTERACTION ✅ 0.93 0.93 mint 24981860
PRKAA1 PRKAB1 â—¼   PHOSPHORYLATION ✅ + 0.93 0.93 Signor 17728241
ATP6V1B2 RRAGA â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
ATG4B GABARAPL1 â—¼   PHYSICAL_INTERACTION 935.0 0.93 STRING 36370105
CCND2 CDK6 â—¼   PHYSICAL_INTERACTION 939.0 0.94 STRING 36370105
EIF3E EIF3G â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 28514442 17403899 33961781 24981860 26186194 22939629 26344197
YWHAB TSC2 â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 12438239 5215924
EIF3D EIF3I â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 28514442 22190034 33961781 24981860 26186194 22939629
EIF3E EIF3I â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 28514442 17403899 33961781 24981860 26186194 22939629
EIF3I EIF3K â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 28514442 33961781 24981860 26186194 22939629
ATP6V1B2 ATP6V1G2 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
MTOR RRAGA â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
MTOR ULK1 â—¼   PHYSICAL_INTERACTION 946.0 0.94 STRING 36370105
COX6B1 COX7C â—¼   PHYSICAL_INTERACTION 946.0 0.94 STRING 36370105
CDKN1A CCND2 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 16765349 5218735
ERBB2 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 5218411 16516204
JAK1 IRS1 â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 11162588 7499365 9492017
CCND2 CDK4 â—¼   PHYSICAL_INTERACTION 949.0 0.95 STRING 36370105
EIF3C EIF3D â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 18599441 22190034 22863883 33961781 24981860 23623729 22939629 26344197
EIF3D EIF3K â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 18599441 22190034 22863883 33961781 24981860 23623729 22939629 26344197
LAMTOR3 LAMTOR2 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 8153045 21516116
RRAGD RRAGB â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 18497260 33961781 28716898 11073942 20381137 24337580 22424946
RB1CC1 ULK1 â—¼   PHYSICAL_INTERACTION 951.0 0.95 STRING 36370105
COX6A2 COX6C â—¼   PHYSICAL_INTERACTION 952.0 0.95 STRING 36370105
RHEB RPTOR â—¼   PHYSICAL_INTERACTION 953.0 0.95 STRING 36370105
RRAGB RRAGD â—¼   PHYSICAL_INTERACTION 953.0 0.95 STRING 36370105
CCNE2 CDKN1A â—¼   PHYSICAL_INTERACTION 954.0 0.95 STRING 36370105
CDK2 CDKN1A â—¼   PHOSPHORYLATION ✅ - 0.95 0.95 Signor 15964852
ERBB2 GRB2 â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
BRAF MAP2K2 â—¼   PHYSICAL_INTERACTION 958.0 0.95 STRING 36370105
CCND1 CDK2 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 9840943 28514442 8647086 33854235 8479754 26496610 33854239 33961781 23455922 21654808 9178893
HIF1A EP300 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 17382325 5219810
EIF3H EIF3F â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 18599441 28514442 23623729 32269044 31527668 33961781 24981860 26186194 19748344 22939629 19615732 26344197
EIF3F EIF3E â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 17403899 31527668 33961781 24981860 26186194 23623729 22939629 19615732 26344197
EIF3F EIF3I â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 31527668 33961781 26186194 22939629 19615732
EIF3F EIF3C â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 18599441 31527668 33961781 24396066 26186194 24981860 23623729 22939629 19615732 26344197
EIF3F EIF3D â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 31527668 22190034 33961781 24981860 26186194 23623729 22939629 19615732 26344197
EIF3F EIF3G â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 31527668 33961781 24981860 26186194 22939629 19615732 26344197
EIF3F EIF3B â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 18599441 28514442 30573685 18628297 31527668 33961781 24396066 19245811 26186194 24981860 22939629 19615732 26344197
EIF3F EIF3K â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 33961781 24981860 26186194 23623729 22939629 19615732 26344197
EIF3K EIF3H â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 33961781 24981860 26186194 23623729 22939629 19615732 14519125 26344197
EIF3G EIF3H â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 16189514 9822659 32269044 33961781 24981860 26186194 22939629 19615732 26344197
EIF3H EIF3I â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 32867821 33961781 24981860 26186194 22939629 19615732
EIF3H EIF3E â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 17403899 32269044 32867821 22863883 33961781 24981860 26186194 23623729 22939629 19615732 26344197
EIF3H EIF3B â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 18599441 28514442 18628297 32269044 33961781 24981860 26186194 22939629 19615732 26344197
EIF3H EIF3D â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 32269044 22190034 22863883 33961781 24981860 26186194 23623729 22939629 19615732 26344197
EIF3K EIF3G â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 33961781 24981860 22939629 14519125 26344197
EIF3D EIF3G â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 9822659 22190034 33961781 24981860 26186194 22939629
EIF3E EIF3D â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 18599441 28514442 17403899 22190034 22863883 33961781 24981860 20890303 23623729 22939629 26344197
EIF3B EIF3D â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 18599441 18628297 22190034 33961781 24981860 22939629 26344197
EIF3C EIF3E â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 18599441 17403899 10504338 22863883 33961781 24981860 23623729 22939629 26344197
EIF3B EIF3E â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 18599441 28514442 17403899 18628297 33961781 24981860 22939629 26344197
EIF3E EIF3K â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 18599441 28514442 17403899 23623729 22863883 33961781 24981860 19748344 22939629 26344197
EIF3K EIF3B â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 18599441 18628297 24981860 22939629 26344197
EIF3K EIF3C â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 18599441 22863883 33961781 24981860 23623729 22939629 14519125 26344197
RRAGC RRAGB â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 25567906 21981924 33961781 28716898 11073942 20381137 25561175 24337580 22980980 22424946
RRAGC RRAGA â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 16189514 25567906 21981924 16713569 31601708 21816923 23184942 33961781 26186194 33157014 11073942 28716898 20381137 25561175 24337580 25936802 22424946
PRKAB1 PRKAG2 â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
PRKAB2 PRKAG2 â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
PRKAA2 PRKAG2 â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
PRKAA1 PRKAG2 â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
ATG13 ULK1 â—¼   PHYSICAL_INTERACTION 962.0 0.96 STRING 36370105
COX6B1 COX6C â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
EIF3I EIF3J â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
PRKAA1 PRKAB2 â—¼   PHYSICAL_INTERACTION 967.0 0.96 STRING 36370105
CDK6 CCND1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 15232106 16713569 10022865 24855949 17517622 33854235 11739795 14681455 24953629 11360184 33961781 10580009 17420273 21654808 11160398 9178893 19075005
CCNE2 CDK2 â—¼   PHYSICAL_INTERACTION 969.0 0.97 STRING 36370105
CCNE2 CDK2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 15232106 9840943 28514442 24358021 9858585 26496610 14681455 25852190 9840927 33961781 26186194 23602568 23455922
EGFR EGF â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 8145580 21439278
EGFR EGF â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 16274239 25241761 10085134 11684674 28988771 22729867 18271526 30083275 10788520 23597562 19531499 26280537 8663535 25453753 21822280 12297050 2790960 21439278 12093292 12620237 10970856 18427122 25080504 17697999 9135143 15620700
EGFR GRB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 19254954 7518560 31980649 9416834 7592693 23956138 14679214 10085134 7510700 27059931 21706016 25402006 16799092 16729043 8665853 15657067 24797263 12577067 8810325 7650032 11960376 23799367 25187647 8626525 10026169 19289468 18271526 21278786 7506413 17971399 8940013 20124286 11726515 9886492 10595738 24189400 9020117 19531499 20473329 9020193 8662998 8647858 1322798 8887653 10229072 16273093 25754235 31959764 11370743 16713569 21596750 9685397 24658140 31985874 22973453 11896612 20067773 17242169 19836242 8810340 21278788 30544639 7527043 9050991 11408594 8621459
HIF1A EP300 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 15280364 19589782 16543236 11823643 22807441 19666581 16189267 18047470 15342390 12042299 19680224 22735262 23448368 26135796 23618863 14691445 19696166 11959990 27320910 16847340 24821806 22789427 17906695 8917528 20620956 20000859 15261140 16081065 12778114 22219185 15154850 25192544 22075993 19071119 22908229 19940151 21187066 24421387 23880760 11940656 23966271 26826385 26944191 12588875 23746844 11063749 27808477 19074848 20603618 15155277 18268343 20829524 21148070 12914934 17502379 22684029 17382325 26751287
ERBB2 GRB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 9710588 11173924 21278786 16713569 9756944 24189400 31980649 22973453 24658140 30898150 16273093 17875712 16729043 11606575 8665853
IRS1 GRB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 7488107 8388384 7486683 8810325 22974441 21706016 8491186 7629070 12173038 8536716
RICTOR MTOR â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 24036451
MTOR RICTOR â—¼   COLOCALIZATION ✅ 0.97 0.97 mint 21045808 8088164
EIF3A EIF3F â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 18599441 9822659 22939629 31527668 17353931 33961781 24396066 19245811 26186194 23623729 9341143 19615732 14519125 26344197
EIF3A EIF3H â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 18599441 9822659 32269044 17353931 22863883 33961781 24981860 26186194 23623729 22939629 19615732 14519125 26344197
EIF3H EIF3C â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 18599441 32269044 22863883 33961781 24981860 26186194 30021884 23623729 22939629 19615732 26344197
TSC1 TSC2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 16464865 25263562 11290735 17077083 12511557 11741832 10807585 11175345 20166753 15342917 30514904 11741833 17658474 15963462 16339216 20169078 10585443 14551205 9580671 12167664 10915759 16424383 20412061 12869586 16636147 9809973 14651849 28561026 15851513 17693255 21134130 15340059 12176984 15851026
EIF3A EIF3D â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 18599441 9822659 22939629 17353931 22190034 22863883 33961781 24981860 23623729 9341143 14519125 26344197
EIF3A EIF3E â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 18599441 17403899 17353931 11590142 22863883 33961781 24981860 23623729 22939629 14519125 26344197
EIF3A EIF3K â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 18599441 17353931 22863883 24981860 23623729 22939629 14519125 26344197
RHEB TSC2 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
PRKAA1 PRKAG1 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
BCL2L1 BCL2L11 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
MTOR RRAGC â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
PRKAA1 PRKAB1 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
AKT1S1 MTOR â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
FN1 ITGB3 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
AKT1S1 RPTOR â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
EIF3I EIF3L â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
EIF3G EIF3J â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
CDKN1A CDK2 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 16765349 5218735
GRB2 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 16729043 5218694
RPTOR MTOR â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 24036451
MTOR RPTOR â—¼   COLOCALIZATION ✅ 0.98 0.98 mint 21045808 8088164
EIF4EBP1 EIF4E â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 16504179 5218377
EIF3B EIF3C â—¼   PROTEIN_INTERACTION 0.98 0.98 HIPPIE 18599441 22939629 18628297 33961781 24981860 19245811 15946946 26344197
CDC37 CDK4 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
LAMTOR3 RPTOR â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
TSC1 TSC2 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
LAMTOR3 SLC38A9 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
ATP6V1B2 ATP6V1F â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
LAMTOR3 RRAGA â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
CCND1 CDKN1A â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
EGF EGFR â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
EGFR ERBB2 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
EIF4EBP1 MTOR â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
MAP2K2 MAPK1 â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
MAPKAP1 MLST8 â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
EIF3C EIF3J â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
CDK4 CDKN1A â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
ATP6V1B2 ATP6V1D â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
ATP6V1D ATP6V1F â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
EIF3D EIF3L â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
EIF3B EIF3L â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
ATG101 ATG13 â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
MTOR RPTOR â—¼   PHOSPHORYLATION ✅ + 0.98 0.98 Signor 19346248
EIF3G EIF3L â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
CCND1 CDK4 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 28514442 25416956 25241761 8259215 9372967 29142209 9150368 18537972 16431923 33854235 24292678 9178893 33854239 9106657 14681455 8867812 8662825 17420273 19767775 16985050 19075005 12519773 21306487 26203195 24855949 23007395 11360184 10580009 11463845 17081987 8978686 16613857 15681588 21242975 15232106 9837900 24218572 27130439 10022865 25910212 9228064 12036906 23707388 23543736 27107012 23718855 19470470 31217276 10908655 8756624 25502805 17205132 33961781 20837141 19237565 21654808 11160398 7568034
EIF3C EIF3G â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 28514442 18599441 16189514 9822659 33961781 24396066 26186194 24981860 22939629 26344197
EIF3B EIF3G â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 18599441 14688252 28514442 9822659 18628297 22863883 33961781 24396066 26186194 24981860 30021884 22939629 26344197
EIF3G EIF3I â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 18599441 28514442 17094969 22863883 33961781 24981860 26186194 22939629 26344197
EIF3G EIF3A â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 28514442 18599441 9822659 22939629 33961781 24396066 26186194 24981860 9341143 14519125 26344197
CCND2 CDK4 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 28514442 16189514 14681455 32296183 9325318 11360184 30217970 28205554 15169570 10022865 17873913 25910212 27107012 28628118 33961781 26186194 11896535 9178893 11971966
EIF3B EIF3A â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 18599441 14688252 30573685 9822659 18628297 8995410 11169732 24981860 17469741 16541103 19245811 22939629 14519125 26344197
EIF3L EIF3K â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 18599441 28514442 16189514 25416956 32296183 23623729 22863883 33961781 24981860 21516116 19748344 22939629 26344197
EIF3C EIF3L â—¼   PHYSICAL_INTERACTION 989.0 0.99 STRING 36370105
EIF3C EIF3I â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 28514442 18599441 33961781 24981860 26186194 22939629 26344197
EIF3B EIF3I â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 28514442 14688252 18599441 18628297 22863883 33961781 24981860 16541103 26186194 22939629 26344197
PRKAB2 PRKAG1 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
LAMTOR2 MTOR â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
MAPKAP1 MTOR â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
PRKAA2 PRKAB2 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
PRKAA2 PRKAG1 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
LAMTOR2 RRAGB â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
RRAGB SLC38A9 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
LAMTOR3 RRAGD â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
EIF3F EIF3L â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
EIF3H EIF3L â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
EIF3A EIF3L â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
EIF3E EIF3L â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
EIF3L EIF3M â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
LAMTOR4 RRAGB â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
LAMTOR3 RRAGB â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
PRKAB1 PRKAG1 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
MTOR RHEB â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB2 GNG5 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB2 GNGT2 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB2 GNG4 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
EIF3C EIF3D â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
EIF3B EIF3D â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
EIF3C EIF3K â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
EIF3B EIF3C â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
EIF3C EIF3I â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
EIF4EBP1 RPTOR â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
EIF3C EIF3H â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
EIF3D EIF3G â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
EIF3C EIF3G â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
MAPKAP1 RICTOR â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
EIF3A EIF3C â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
EIF3C EIF3E â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
EIF3B EIF3J â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
EIF3C EIF3M â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
CDC37 HSP90AA1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
MLST8 MTOR â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
EIF3C EIF3F â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
EIF3F EIF3I â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
EIF3H EIF3I â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
EIF3G EIF3I â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
EIF4E EIF4EBP1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
EIF3A EIF3J â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
EIF3D EIF3I â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
EIF3E EIF3I â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
EIF3I EIF3K â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
EIF3K EIF3L â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
EIF3I EIF3M â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
EIF3B EIF3F â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
EIF3A EIF3F â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
EIF3D EIF3F â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
EIF3F EIF3M â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
EIF3D EIF3H â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
EIF3A EIF3H â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
EIF3B EIF3H â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
EIF3B EIF3G â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
EIF3A EIF3D â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
EIF3D EIF3K â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
EIF3D EIF3M â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
EIF3B EIF3I â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RRAGB RRAGC â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
RRAGA RRAGD â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCND1 CDK4 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CDK2 CDKN1A â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EGFR GRB2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EP300 HIF1A â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR2 RPTOR â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR4 RPTOR â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
RPTOR RRAGC â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EIF3E EIF3F â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EIF3F EIF3K â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EIF3F EIF3G â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EIF3F EIF3H â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EIF3E EIF3H â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EIF3G EIF3H â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EIF3H EIF3K â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EIF3H EIF3M â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EIF3E EIF3G â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EIF3A EIF3G â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EIF3G EIF3M â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EIF3G EIF3K â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
GNB2 GNG2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EIF3A EIF3I â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EIF3A EIF3K â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EIF3A EIF3E â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EIF3A EIF3M â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EIF3A EIF3B â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EIF3D EIF3E â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EIF3B EIF3E â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EIF3E EIF3M â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EIF3E EIF3K â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EIF3B EIF3K â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EIF3K EIF3M â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EIF3B EIF3M â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR3 LAMTOR4 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR2 LAMTOR4 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR4 SLC38A9 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR4 RRAGA â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR4 RRAGC â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR2 SLC38A9 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR2 RRAGC â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR2 LAMTOR3 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR2 RRAGA â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
RRAGA SLC38A9 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
LAMTOR3 RRAGC â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
RRAGC SLC38A9 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
MLST8 ATG13 â—¼   ENZYMATIC_REACTION ✅ 27.0 1.0 ACSN 11274345 11756498 12150925 12408816 12906785 15755954 16469695 17680028 18000759 18492954 19022819 19151919 19225151 19446321 19568798 19706736 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
RPTOR ATG13 â—¼   ENZYMATIC_REACTION ✅ 27.0 1.0 ACSN 11274345 11756498 12150925 12408816 12906785 15755954 16469695 17680028 18000759 18492954 19022819 19151919 19225151 19446321 19568798 19706736 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
MTOR ATG13 â—¼   ENZYMATIC_REACTION ✅ 27.0 1.0 ACSN 11274345 11756498 12150925 12408816 12906785 15755954 16469695 17680028 18000759 18492954 19022819 19151919 19225151 19446321 19568798 19706736 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
ULK1 ATG13 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 15197469 19225151 21460630 18936157 27932573 19287211 19597335 27390127 27387056 27203176 25686248 26018823 20562859 23524951 33450483 26687599 19211835 23392225 26138443 25126726
MTOR ATG13 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 24.0 1.0 Omnipath 12150925 18000759 19225151 21157483 17680028 19151919 19864431 26801615 15755954 19446321 19258318 19706736 12408816 19211837 11274345 19211835 19568798
ATG101 ATG13 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 20562859 23392225 26299944 19287211 24290141 19597335 24100292
ATG13 RB1CC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 20562859 19225151 23392225 19597335 19211835
FKBP8 BCL2L1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16189514 12510191 15733859
BCL2L11 BCL2L1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 34.0 1.0 Omnipath 17145710 16697956 9430630 17525735 22516262 18498746 10198631 21199865 20836993 26186194 15694340 17289999 27013495 32296183 23245996 11859372 19427863 21671007 14596824 9731710 16260615
BNIP3 BCL2L1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16189514 10625696
FOXO3 BCL2L11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 22349704 12913110 19623194 20231287 22914323 17618288 15674333 21164521 15688014 17626006 21654193 14527951 16373335 14981546 23257900 19690465
FOXO3 BCL2L11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 17604722 11495903 11301023 18644865 19494111 10783894 14684737 16288288 15688014 11050388 11094066 18281283 20673124 17646672 15509806 11994454 11154281
MAPK9 BCL2L11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 15486195 14555991 18691976 18174237 12591950 15470142 12818176
MAPK3 BCL2L11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 15486195 25915848 17604722 14555991 28474232 19150432 18174237 12646560 12818176 15486085 15212693 14681225
MAPK1 BCL2L11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 15486195 17604722 14555991 28474232 19150432 12646560 16282323 12818176 17570479 15486085 15212693
HIF1A CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23455892 20360945 20179204 15991006
EP300 CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 17306568 17666529 11788592 23343194 21285352 15576399 21151179 22761862 22290435 16039586 19619488 19623618 17143292
GSK3B CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 87.0 1.0 Omnipath 26907733 16944320 27546592 11967263 14663202 8524413 16504004 29969496 19767775 21347341 25142862 11311237 30736789 14597415 25591548 19645770 10385618 20548028 10766840 10929713 23565238 16039586 17570479 18818515 18167338 12615961 12413951 17046823 19071090 18598945 15465828 19374252 26121043 26432751 18319725 12969793 23733133 22922870 24134204 10486203 12459251 15020233 18769147 10910956 11152665 21317297 20537194 22099186 18328826 11124803 17070615 19757160 22470469 23552696 16732330 27695879 29554905 16103118 15075324 14536078 9832503 28090171
CDKN1A CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 31.0 1.0 Omnipath 26203195 23443559 17145710 25416956 7478582 9837900 21988832 21516116 7777546 15232106 16082198 27107012 15695403 8657154 8242751 23007395 9106657 12383116 17556661 8756624 8662825 31515488
CCND1 CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 63.0 1.0 Omnipath 26203195 17145710 8978686 12036906 23562856 25416956 16985050 23707388 19767775 9837900 17517622 19237565 9372967 25502805 23718855 9228064 7736585 15232106 11360184 20837141 21306487 25910212 25241761 27107012 9150368 18537972 9178893 31217276 8867812 10580009 23007395 11160398 19470470 19075005 9106657 8259215 10908655 8756624 23543736 24855949 7568034 24218572 8662825 31515488 17205132
CCND1 CDK6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 19075005 17517622 9178893 11739795 24855949 15232106 16713569 11360184 10580009 11160398
CDK1 TSC1 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 14551205 15279786 17303408 17660363 18414028 18590585 7575488
GSK3B CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 9832503 17359287
CDKN1A CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 9467962 26186194 21308745 15340381 23602568 23543736 24218572 17679094 15077146 26496610 12973835
ERBB2 CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 55.0 1.0 Omnipath 18927589 17938195 10770932 17276342 17396146 11836499 17409144 29088738 19276355 26673326 19933706 28335434 20372791 7743995 11322924 19683496 27889260 17466630 14681223 12384528 12049736 7841526 12110582 25744022 18393321 15582998 19861462 14987992 20144215 17466629 16546994 19858290 15136770 14767478 20368335 25994202 10504341 1850698 15350223 24910099 9268380 15296723 8428596 24391510 18469858 8662825 20530684 11782384 15141014 15940258 12766774
CDK1 KIF11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 26615533 19007248 16565220 19691289 19001501 28487562 19664994 20068231 16455663 25660025 19690332 8548803 21522128 19413330 9235942 20068230
CDK1 TSC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 11444800 14551205 18414028 20006582
CDK1 EIF4EBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 11691836 27402756 11553333 17570479 12588975 29610153
CDK1 SQSTM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 26279575 22424619 23856904 20974803 29423120 17570479 28963527
CDK1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 17145710 31980649 8360196 23956138 15901825 28150246 18271526 15657067 24658140 25402006 15302935
MAPK1 CDK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10962581 12359725
CDK2 RRN3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12124936 19815529 15004009
CDK2 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 94.0 1.0 Omnipath 23443559 23455922 10878006 20100570 23602568 15964852 20839231 25416956 23737759 9840943 18850315 11302688 20519948 24358021 19440234 15557281 9472014 9658399 16962592 9736735 12949733 8641969 10022118 15890360 12839982 16765349 17418410 15647383 10874474 15232106 17570479 17698606 12361598 26496610 9632134 24419005 12417722 16189514 26186194 20587660 25241761 8622677 9660939 25483090 12800980 20102411 10918595 12058028 12144826 8242751 9464540 9858587 29899857 23007395 11477082 9218599 12383116 25463440 12730199 8756624 9284049 9380407 9546435 24218572 16964243 15212693 13678583
CDKN1A CDK6 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 14517297 17092340 9106657 18710949 24515438 20843055
FOXO3 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18312651 18005957 16908841 20671123 21249150
STAT1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 20738848 11162600 12239594 16449678 21307941 22591439 10023678 10866323
HIF1A CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15071503 15190211 10559391 20043814 21362093
EP300 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10362258 15509808 21858218 22000024 21245169
MDM2 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17373842 25241761 20086099 14633995 14761977 20308078
AKT2 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 19216069 17680028 11756412 16680151 20214616 11463845 21933447 16982699 20452955 9829964 20398329 17646672 10217147
MAPK1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 20519948 19364816 28368408
FOXO3 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15084259 19380174 21708191 15084260 21613825 17940099 11154281
CDK6 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 25121590 20102411 15964852 22375140 15232106 16713569 16508017 19440234
GSK3B CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 22154077 28916781 12058028 11779850 17570479 20519948 15212693 17283049 19440234
MAPK14 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23745637 12058028
CDKN1A CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 23443559 26186194 25241761 27107012 8756624 15169570 25416956 16765349 31515488 16189514 32296183
CDKN1A CCNE2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 17145710 23443559 26186194 28514442 9840927 9840943 15232106 26496610 24358021
CDKN1A CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 27.0 1.0 Omnipath 23443559 15169570 18850315 9658399 16962592 15232106 9632134 16189514 8622677 15695403 20102411 8242751 9464540 23007395 7626805 9106657 12383116 30193583 17556661 23543736 8756624
EGF EGFR â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 15003992 15175028 15466195 15958574 18423981 19631971 20430953 21098712 8101258
EGFR GRB2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 10404636 20430953 23010081 25987127 28513565
MAPK1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 12556561 1651322 17081983 3138233 15901825 1939237 91332050 2543683 2115882 17192257 1651323 15302935
MAPK3 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 22.0 1.0 Omnipath 1651322 17081983 3138233 15901825 16785992 1939237 91332050 27531070 17570479 2543683 2115882 34086370 17192257 1651323 15302935
AREG EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 23331499 23762360 21071413 10209155 10085134 29045902 2466334 20513444 16713569
MAPK14 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 15187187 18039929 19138820 7535770 12738796 17139251 16932740 23397142 16785992 11274345
EGF EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 131.0 1.0 Omnipath 17145710 17081983 21822280 20813200 23613900 9135143 25453753 21303971 10209155 26821125 12297050 27387652 25241761 30083275 12093292 30197274 21649524 19531499 18762250 16729043 26921391 17697999 17575160 21722395 12620237 19129184 10788520 23331499 3494473 15620700 14568001 15958209 24096486 18253097 16843263 18320059 21532939 10085134 22260327 15708576 26280537 23912460 21858221 11116185 10970856 27462018 18427122 25080504 20953304 19135477 11684674 8639530 27564112 18270696 2790960 17971399 23185569 19895983 28988771 29617357 23597562 19531623 23950932 21071413 8663535 6289330 16274239 17563729 21439278 20458382 22216880 18271526 12771140 21311755 24709886 25366117 12648462 21107857
EGFR GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 109.0 1.0 Omnipath 9544989 10595738 23956138 27059931 10026169 16273093 11726515 24697349 21596750 19289468 7518560 21706016 23799367 9050991 16317285 16713569 25402006 11370743 24797263 8647858 8887653 9416834 21278786 16799092 8662998 10229072 11896612 7592693 19509291 8810325 24189400 19836242 11960376 7506413 18271526 15657067 10085134 24658140 17242169 7510700 8940013 7650032 8810340 11084343 12577067 7527043 31980649 11408594 19531499 20124286 23178716 9886492 23181695 9020117 8479540 14679214 12648464 1322798 17991782 16729043 17971399
EGFR ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 65.0 1.0 Omnipath 17081983 16207817 21044682 17148612 24557338 16713569 21203579 10233167 20471394 17389395 17486068 21278786 11500516 11279155 11500850 17426253 16843263 19650109 25241761 24189400 15657067 17307140 18803307 1706616 12354693 10572067 24355130 11408594 19060928 12648464 16516204 15951569 23436906 20211985
EGFR STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 75.0 1.0 Omnipath 23956138 12070153 11839738 10918587 11447289 11997436 14967450 25402006 12040186 24797263 15173823 7543024 15322115 10358079 6321473 11294897 7690989 10982844 19568798 12637327 14585353 15199124 17496910 11438544 10748192 24658140 7657660 12817007 31980649 22693070 9355737 19615955 11152457 15284024 15567848 7592750 16488589
STAT1 EP300 â—¼   PHYSICAL_INTERACTION 22.0 1.0 ACSN 10918613 11134049 11830590 12193701 12223527 12796776 12811837 12967644 14607900 14764699 15265520 15814715 17016554 17513775 17559085 17689680 18272812 19833085 21263073 21930765 25960930 8683106
STAT1 EP300 â—¼   PROTEIN_INTERACTION 22.0 1.0 ACSN 10918613 11134049 11830590 12193701 12223527 12796776 12811837 12967644 14607900 14764699 15265520 15814715 17016554 17513775 17559085 17689680 18272812 19833085 21263073 21930765 25960930 8683106
AKT2 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17964260 16926151
PRKAA1 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 11020388 21940946 12379484 15006641 12590608
MAPK1 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17623675 24530506
EP300 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 75.0 1.0 Omnipath 24821806 12573436 17145710 16847340 12588875 19589782 11940656 25192544 11959990 18519678 23448368 22219185 11823643 12042299 15342390 23746844 19071119 19680224 27808477 15154850 19696166 8917528 17906695 18268343 22735262 21148070 15261140 19940151 23880760 22807441 35430356 14691445 12914934 20000859 12778114 26751287 16081065 22789427 16543236 24421387 17382325 17502379 22684029 21187066 19074848 23618863 23966271 20603618
EP300 CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17306568 17666529 23343194 21285352 15576399 21151179 22761862 22290435 16039586 19619488 19623618 17143292
FBXW7 PPARGC1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18541364 18198341 26971449
HIF1A FOXO3 â—¼   ENZYMATIC_REACTION ✅ 66.0 1.0 ACSN 10102273 10428030 10428780 10435632 10804084 10823814 11557773 11559532 11744734 11756417 11884613 12402042 12676992 12743597 14672622 14684737 14699081 14762718 15024076 15059920 15199147 15240700 15312748 15369676 15379897 15545625 16110315 16126909 16127144 16517405 16517406 16585195 16782875 16888645 17143338 17418790 17533374 17785433 18054315 18056423 18158893 18718909 19211554 20028863 20427344 20535745 20855962 21051947 21765015 22006996 22841746 22850421 22988108 24006507 25043024 25103413 25732824 7493931 7500013 7508926 8089148 8702901 8955077 9486205 9525945 9707622
MDM2 FOXO3 â—¼   ENZYMATIC_REACTION ✅ 14.0 1.0 ACSN 11715018 11779693 11923280 14761977 15024084 15084260 15169778 15876864 16307918 17110379 17158541 19321440 20679392 9450543
FOXO3 INS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16840535 22563476 19608644 12027802
MAPK1 FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 18204439 29445193 22128155 10102273
PRKAA1 FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17900900 17711846 22848740 29445193
AKT2 FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 19951971 19216069 17680028 11756412 17646672 20214616 11463845 20452955 9829964 20398329 10102273 18593906 16680151 10217147 19188143
MAPK14 FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22128155 23857333
FLT1 GRB2 â—¼   PHYSICAL_INTERACTION 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
IRS1 GRB2 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 8316835 8810325 9832424 8621421 8530377 9852124 9003010
GRB2 BRAF â—¼   PHYSICAL_INTERACTION 48.0 1.0 ACSN 10086337 10567412 10811803 10843677 10982827 11023813 11034387 11062502 11385609 11447289 11777939 11907067 12040186 12175651 12419216 12640133 12782630 14585353 14764585 15169888 15536084 15547943 15567848 15574420 15735649 15863030 16102570 16227978 16488589 16582911 16887996 17178906 17395718 17496910 17613518 17673906 19449109 19541618 19565474 19568798 19615955 21102635 22435554 24027568 26552706 7510700 8551221 9510155
GRB2 LAMTOR2 â—¼   PHYSICAL_INTERACTION 53.0 1.0 ACSN 10086337 10567412 10811803 10843677 10982827 11034387 11062502 11385609 11447289 11532940 11777939 11907067 12040186 12175651 12419216 12479806 12566895 12640133 12782630 14585353 14764585 15169888 15516985 15536084 15547943 15567848 15574420 15735649 15863030 16102570 16227978 16488589 16582911 16887996 17178906 17395718 17496910 17673906 18039929 19289794 19449109 19541618 19565474 19568798 19615955 21102635 22435554 24027568 26552706 7510700 8551221 9069260 9510155
GRB2 KLB â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11353842 9632781 14534538 9182757
FLT1 GRB2 â—¼   SHARES_COMPLEX 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
GRB2 LAMTOR2 â—¼   SHARES_COMPLEX 53.0 1.0 ACSN 10086337 10567412 10811803 10843677 10982827 11034387 11062502 11385609 11447289 11532940 11777939 11907067 12040186 12175651 12419216 12479806 12566895 12640133 12782630 14585353 14764585 15169888 15516985 15536084 15547943 15567848 15574420 15735649 15863030 16102570 16227978 16488589 16582911 16887996 17178906 17395718 17496910 17673906 18039929 19289794 19449109 19541618 19565474 19568798 19615955 21102635 22435554 24027568 26552706 7510700 8551221 9069260 9510155
GRB2 BRAF â—¼   SHARES_COMPLEX 48.0 1.0 ACSN 10086337 10567412 10811803 10843677 10982827 11023813 11034387 11062502 11385609 11447289 11777939 11907067 12040186 12175651 12419216 12640133 12782630 14585353 14764585 15169888 15536084 15547943 15567848 15574420 15735649 15863030 16102570 16227978 16488589 16582911 16887996 17178906 17395718 17496910 17613518 17673906 19449109 19541618 19565474 19568798 19615955 21102635 22435554 24027568 26552706 7510700 8551221 9510155
FLT1 GRB2 â—¼   ENZYMATIC_REACTION ✅ 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
IRS1 GRB2 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 10086337 10826997 12175651 12444011 12767520 16931767 17604717 19030972 21540285 22465479 24036369 8621421
GRB2 ITGA4 â—¼   ENZYMATIC_REACTION ✅ 26.0 1.0 ACSN 10086337 10426994 10567412 10811803 10982827 11447289 11777939 11777960 11907067 12175651 12640133 15536084 15567848 15574420 16339513 16582911 16713974 16887996 17070508 17100878 17496910 17673906 18490724 19449109 26552706 8551221
ERBB2 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 31980649 9756944 21278786 16273093 24189400 11173924 9710588 24658140 11606575 14967450 17875712 16713569 16729043
IRS1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 8265614 7862167 11788580 8388384 8491186 8536716 7488107 7486683 10358772 10592173 8196603 12173038 12679424 8114695 11259577 8810325
EGF GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17081983 19531499 17673906 10973965
IRS2 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 7559579 11788580 10358772 11305324 9852124
STAT1 HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 9880553 21430289 12940076 10440232
MAPK1 LAMTOR3 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 21779496 9733512 12479806 15118098 17178906 15547943
MAPK1 LAMTOR2 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 21779496 9733512 12479806 15118098 17178906 15547943
MAPK1 MAP2K2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11802164 15239952 21779496 11802165 15260967
MAPK1 KLB â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
MAP2K2 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 68.0 1.0 Omnipath 21675959 11704645 9694850 17081983 7565670 12750173 19690332 12932319 11823456 18799465 15592455 11337027 18083107 21365009 12788955 11134045 19219045 17389395 9447970 15342917 23331499 19534553 17569879 7559390 23047924 8226933 8223433 17272394 15851026 15811950 19494114 18988627 18669648 11549292 23519423 19541618 18691976 1381507 16293107 17906627 11986622 19933846 8376945 19053285 16094384 11971971 17192257 11136732 11948414 8388392 7898932 9731057 11730323 18039929 11118451 19369195 12920017 15951569 15466214 10746662
MAPK14 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 15187187 21675959 18039929 12738796 11157753 22521293 17255949 11238443 11274345 12697810
MAPK13 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12738796 18039929 11274345 15187187
MAPK1 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12975377 23602568 16424009 19058874 23397142 21707490
MAPK1 DAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 15616583
MAPK1 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 16039586 28646232 18451303
MAPK1 LIPE â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11581251
MAPK1 RPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 21071439 19339977 19864431 21325048 22493283
MAPK1 EIF4EBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 73.0 1.0 Omnipath 17081983 11691836 18767875 11553333 12665511 25702871 19413330 10405182 18187866 19664995 12747827 10942774 9092573 15051500 20068231 9465032 27387559 11410517 11777913 18669648 8083223 12105188 17386266 25762619 17287340 9405468 12588975 12370290 19651622 10779345 27402756 10364159 11799119 26170285 12912989 33658337 16339216 12759354
MAPK1 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 16954218 10551817 18519666 18687685 26784107
MAPK1 TSC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 15342917 15851026 18794886
MAPK1 BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 14654779 21478863 19541618 16508002 19710016 19933846 15664191 29335436 8621729
MAPK1 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 37.0 1.0 Omnipath 15001544 17081983 18949383 16123357 27014871 16914728 17360977 16099428 30401435 16131083 17640984 12510059 15613682 21850561 14579029 20594869 8626671 9395471 19651622 15576463 22289259 14769130 16020478 17242212
MAPK14 PPARGC1A â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 10601328 9374491 17099248 19112161 21451146 11481440
MAP3K7 MAPK14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12589052 17965022 15692051 17947236
MAP2K3 MAPK14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 91.0 1.0 Omnipath 12589052 11279118 17081983 20213747 7914033 18767875 17322306 23602568 8622669 18855897 19690332 23904011 9162092 11426938 15592455 18083107 7997261 12384504 15735649 18291705 23331499 17389395 7535770 19534553 7839144 21071413 16083285 21614932 20068231 12738796 16189514 17255949 18669648 16153436 14970210 26186194 16407200 11242034 18691976 18088087 11304531 15972258 10781613 17192257 18586681 10734320 19651622 7592586 16157584 19369195 9582275 15674326 9528766 7693711 9841871 12758252 11309380 7750576 15212693 15659558 11274345 15735648
MAPK14 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 26822034 17726008 21303975 18451303
MAPK14 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 15187187 21675959 18039929 12738796 23397142 11238443 11274345 12697810
MAPK14 EIF4EBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 35.0 1.0 Omnipath 17081983 11691836 18767875 12665511 17043358 19413330 10405182 19664995 10942774 9092573 20068231 9465032 11777913 18669648 8083223 12105188 17287340 9405468 12370290 19651622 10779345 10364159 12912989
MAPK14 PPARGC1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 17570479 11741533
MAPK14 MAP2K2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12738796 18039929 11274345 15187187
MAPK14 CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17486076 27843138
MAPK14 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 23331499 10201984 17897103 18669648 18691976 11226159 17502367 7543024 19690332 15322115 14963018 25950470 28262979
MAPK3 LAMTOR2 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 21779496 9733512 12479806 15118098 17178906 15547943
MAPK3 LAMTOR3 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 21779496 9733512 12479806 15118098 17178906 15547943
MAPK3 MAP2K2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11802164 15239952 21779496 11802165 15260967
MAPK3 KLB â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
LAMTOR3 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 9733512
MAP2K2 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 101.0 1.0 Omnipath 19901323 17081983 11704645 9694850 12750173 1411546 19690332 12932319 18799465 16497976 18083107 11134045 8626767 9006895 17389395 19219045 15342917 9447970 16887817 23331499 17569879 7867743 7559390 21071413 19534553 8226933 20068231 8223433 17272394 93330262 15851026 15811950 26987942 18988627 19494114 18669648 19541618 11242034 15466476 18691976 1381507 17906627 11986622 19933846 8376945 11971971 17192257 11136732 11948414 7898932 7687743 9731057 19651622 11730323 16464493 18983981 11251083 11118451 15580310 19369195 18707149 12920017 15951569 15466214 10746662 15212693
MAPK13 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12738796 18039929 11274345 15187187
MAPK3 RPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21757713 21071439 19339977 19864431
MAPK3 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10551817 18519666 24099156
MAPK3 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 15001544 16131083 8626671 14769130 9335553 15613682 12510059 15212693 9395471 14579029
MAPK3 DAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17145710 25241761 15616583 26769850
MAPK3 BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 14654779 21478863 19541618 21135229 16508002 19933846 15664191 8621729
MAPK3 LIPE â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11581251
MAPK3 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 16039586 28646232
MAPK3 RRN3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12620228
MAPK3 TSC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 15342917 16244323 15851026 18794886 19188143
NUMB MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 18172499 31451549 35044719 16678796 27106262 20940030 28223335 22337874 9632782 23252402 12646252
AKT2 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 19216069 17680028 11756412 16680151 20214616 11463845 20452955 9829964 20398329 11504915 17646672 10217147
MDM2 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 15880652 25535359 12606552 25447306 17234751 19696166 10640274
MDM2 NUMB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 18172499 31451549 35044719 16678796 27106262 28223335 22337874 9632782 23252402 12646252
MTOR MLST8 â—¼   PHYSICAL_INTERACTION 88.0 1.0 ACSN 10702316 10722653 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16556040 16678438 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17461779 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20027184 20138985 20338997 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21533173 21621563 21708191 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025 9069260
MLST8 PPARGC1A â—¼   PHYSICAL_INTERACTION 22.0 1.0 ACSN 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MLST8 PRR5 â—¼   PHYSICAL_INTERACTION 18.0 1.0 ACSN 12408816 12906785 16469695 17680028 18492954 18566586 19022819 19143635 19568798 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MLST8 MAPKAP1 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10722653 11274345 11756498 12408816 12906785 16469695 16556040 16678438 17461779 17680028 18000759 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19151919 19446321 19568798 19706736 19720745 20027184 20338997 21157483 21474067 21533173 21621563 21708191 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
MLST8 RICTOR â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10722653 11274345 11756498 12408816 12906785 16469695 16556040 16678438 17461779 17680028 18000759 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19151919 19446321 19568798 19706736 19720745 20027184 20338997 21157483 21474067 21533173 21621563 21708191 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
MLST8 DEPTOR â—¼   PHYSICAL_INTERACTION 37.0 1.0 ACSN 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17461779 17604271 17680028 18000759 18372248 18492954 19022819 19143635 19143636 19151919 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
MLST8 RPTOR â—¼   PHYSICAL_INTERACTION 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
MTOR MLST8 â—¼   SHARES_COMPLEX 88.0 1.0 ACSN 10702316 10722653 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16556040 16678438 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17461779 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20027184 20138985 20338997 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21533173 21621563 21708191 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025 9069260
MLST8 RICTOR â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 10722653 11274345 11756498 12408816 12906785 16469695 16556040 16678438 17461779 17680028 18000759 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19151919 19446321 19568798 19706736 19720745 20027184 20338997 21157483 21474067 21533173 21621563 21708191 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
MLST8 PRR5 â—¼   SHARES_COMPLEX 18.0 1.0 ACSN 12408816 12906785 16469695 17680028 18492954 18566586 19022819 19143635 19568798 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MLST8 DEPTOR â—¼   SHARES_COMPLEX 37.0 1.0 ACSN 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17461779 17604271 17680028 18000759 18372248 18492954 19022819 19143635 19143636 19151919 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
MLST8 PPARGC1A â—¼   SHARES_COMPLEX 22.0 1.0 ACSN 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MLST8 RPTOR â—¼   SHARES_COMPLEX 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
MLST8 MAPKAP1 â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 10722653 11274345 11756498 12408816 12906785 16469695 16556040 16678438 17461779 17680028 18000759 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19151919 19446321 19568798 19706736 19720745 20027184 20338997 21157483 21474067 21533173 21621563 21708191 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
MTOR MLST8 â—¼   ENZYMATIC_REACTION ✅ 88.0 1.0 ACSN 10702316 10722653 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16556040 16678438 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17461779 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20027184 20138985 20338997 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21533173 21621563 21708191 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025 9069260
SQSTM1 MLST8 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 15340068 16252010 20531300 21981924 25002027 26587781 28574505
MLST8 RPTOR â—¼   ENZYMATIC_REACTION ✅ 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
MLST8 DEPTOR â—¼   ENZYMATIC_REACTION ✅ 37.0 1.0 ACSN 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17461779 17604271 17680028 18000759 18372248 18492954 19022819 19143635 19143636 19151919 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
MLST8 PPARGC1A â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MLST8 DEPTOR â—¼   DOWN_REGULATES ✅ - 37.0 1.0 ACSN 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17461779 17604271 17680028 18000759 18372248 18492954 19022819 19143635 19143636 19151919 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
MTOR MLST8 â—¼   LOCALISATION ✅ 88.0 1.0 ACSN 10702316 10722653 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16556040 16678438 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17461779 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20027184 20138985 20338997 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21533173 21621563 21708191 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025 9069260
MLST8 RPTOR â—¼   LOCALISATION ✅ 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
RHEB MLST8 â—¼   UP_REGULATES ✅ 7.0 1.0 ACSN 12906785 16636147 17604271 18466115 19022819 19143635 23087689
RHEB MLST8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 17604271 15854902 19299511 16636147 12718876 15878852 17470430 19143635 12906785 18466115
MTOR DEPTOR â—¼   PHYSICAL_INTERACTION 37.0 1.0 ACSN 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17461779 17604271 17680028 18000759 18372248 18492954 19022819 19143635 19143636 19151919 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
MTOR PRR5 â—¼   PHYSICAL_INTERACTION 18.0 1.0 ACSN 12408816 12906785 16469695 17680028 18492954 18566586 19022819 19143635 19568798 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MTOR RICTOR â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10722653 11274345 11756498 12408816 12906785 16469695 16556040 16678438 17461779 17680028 18000759 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19151919 19446321 19568798 19706736 19720745 20027184 20338997 21157483 21474067 21533173 21621563 21708191 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
MTOR RPTOR â—¼   PHYSICAL_INTERACTION 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
MTOR MAPKAP1 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10722653 11274345 11756498 12408816 12906785 16469695 16556040 16678438 17461779 17680028 18000759 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19151919 19446321 19568798 19706736 19720745 20027184 20338997 21157483 21474067 21533173 21621563 21708191 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
MTOR PPARGC1A â—¼   PHYSICAL_INTERACTION 22.0 1.0 ACSN 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MTOR MAPKAP1 â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 10722653 11274345 11756498 12408816 12906785 16469695 16556040 16678438 17461779 17680028 18000759 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19151919 19446321 19568798 19706736 19720745 20027184 20338997 21157483 21474067 21533173 21621563 21708191 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
MTOR DEPTOR â—¼   SHARES_COMPLEX 37.0 1.0 ACSN 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17461779 17604271 17680028 18000759 18372248 18492954 19022819 19143635 19143636 19151919 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
MTOR RICTOR â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 10722653 11274345 11756498 12408816 12906785 16469695 16556040 16678438 17461779 17680028 18000759 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19151919 19446321 19568798 19706736 19720745 20027184 20338997 21157483 21474067 21533173 21621563 21708191 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
MTOR RPTOR â—¼   SHARES_COMPLEX 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
MTOR PPARGC1A â—¼   SHARES_COMPLEX 22.0 1.0 ACSN 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MTOR PRR5 â—¼   SHARES_COMPLEX 18.0 1.0 ACSN 12408816 12906785 16469695 17680028 18492954 18566586 19022819 19143635 19568798 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
SQSTM1 MTOR â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 15340068 16252010 20531300 21981924 25002027 26587781 28574505
MTOR RPTOR â—¼   ENZYMATIC_REACTION ✅ 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
MTOR PPARGC1A â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MTOR DEPTOR â—¼   ENZYMATIC_REACTION ✅ 37.0 1.0 ACSN 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17461779 17604271 17680028 18000759 18372248 18492954 19022819 19143635 19143636 19151919 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
MTOR DEPTOR â—¼   DOWN_REGULATES ✅ - 37.0 1.0 ACSN 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17461779 17604271 17680028 18000759 18372248 18492954 19022819 19143635 19143636 19151919 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
MTOR RPTOR â—¼   LOCALISATION ✅ 72.0 1.0 ACSN 10702316 11108711 11274345 11756498 12150925 12408816 12533512 12709531 12713446 12844354 12867079 12906785 15314020 15749884 15755954 15905173 16286006 16469695 16679021 16713974 16915281 17052453 17053147 17368478 17404308 17604271 17680028 18000759 18046414 18048642 18372248 18391071 18423201 18492954 19022819 19143636 19151919 19225151 19244117 19339977 19446321 19568798 19597330 19706736 19720745 19864431 19930715 20138985 20547845 20647036 20805416 20832730 20932932 21157483 21177869 21233202 21474067 21981924 22504639 23087689 24795729 24973821 25002027 25682865 25730849 26159692 26597054 27328425 27331412 27510662 27572739 28216025
RHEB MTOR â—¼   UP_REGULATES ✅ 7.0 1.0 ACSN 12906785 16636147 17604271 18466115 19022819 19143635 23087689
FKBP8 MTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 24205284 17991864
RPTOR MTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 139.0 1.0 Omnipath 15268862 24403073 20427287 22258093 21321085 19446321 15467718 19875983 17461779 12665511 12719976 16631613 21045808 21177249 23911927 24337580 25446900 24516643 18614546 12718876 12747827 16603397 17043309 18519641 22544753 25007995 27043084 19145465 23953116 19619545 16919458 24375676 15459249 16837165 16847060 25332233 12150926 22424946 26348909 12150925 18955708 20381137 22356909 17386266 17565979 18030348 16354680 20169205 19114562 21071439 27329724 35561222 16798736 15809305 22493283 17277771 15661536 16962653 1683716516603397 17604271 18676370 16183647 18505677 23297343 23872070 24036451 15066126 18570873 21614075 18722121 12408816 17599906
RHEB MTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 35.0 1.0 Omnipath 18670866 18075516 18550814 16631613 18466115 16915281 23331499 15772076 16098514 20006481 15878852 21071413 23272152 19299511 15854902 19487463 20226003 19143635 17604271 16636147 17470430 12906785
MTOR AKT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 20338882 17517883 18372248 19203586 27418134 17277771 15718470 26491696
MTOR IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 22570710 15952059 19561084 21282364 25973388 14769130 11287630 9335553 17698034 20863384
MTOR DEPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 22017877 22017876 22017875 19446321 28086984
MTOR ULK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 70.0 1.0 Omnipath 18000759 19225151 21157483 25759175 15755954 28464882 19446321 27681874 26417067 28518135 19706736 24119841 27325266 26906453 27731364 29686608 25026281 27935582 28366635 28674405 27617292 26869683 29507183 25679763 28389629 25686248 19568798 27387347 21383122 26118643 32134989 26887051 12150925 29540819 29849901 10995454 23136410 30093610 19864431 24358342 26844203 29787772 30127742 19690328 21460634 26447757 26589724 21258367 22770472 29057166 29752434 29066806 17680028 19151919 24998849 30174616 26734992 17595159 12408816 11274345
MTOR AKT1S1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 25.0 1.0 Omnipath 17604271 17386266 18030348 28978182 19114562 17517883 26876939 18570873 18372248 17277771
MTOR EIF4EBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 132.0 1.0 Omnipath 17510057 17081983 11691836 22873724 18767875 16824195 19147279 23077579 24303063 28272965 19690332 11438723 12665511 17043358 19413330 10405182 20670887 19209957 19664995 15070431 9826548 12747827 10942774 16242075 9092573 12604610 20068231 9465032 21190521 23360111 17991864 25686248 9204908 11777913 18669648 12150926 8083223 20537536 12105188 17386266 24205284 17517883 26985829 19291795 23972597 16288292 17487921 8895571 17287340 9405468 20227039 12588975 12370290 17717968 23486913 19651622 10779345 26255626 18220336 16404421 18283322 10364159 15066126 12912989 17693255 15767663
RPTOR RRAGA â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
RPTOR DEPTOR â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18000759 18372248 18492954 19022819 19143636 19151919 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
RPTOR PPARGC1A â—¼   PHYSICAL_INTERACTION 22.0 1.0 ACSN 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
RPTOR FKBP8 â—¼   PHYSICAL_INTERACTION 7.0 1.0 ACSN 12150925 15755954 16469695 17991864 19864431 23087689 26159692
RPTOR FKBP8 â—¼   PROTEIN_INTERACTION 7.0 1.0 ACSN 12150925 15755954 16469695 17991864 19864431 23087689 26159692
RPTOR DEPTOR â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18000759 18372248 18492954 19022819 19143636 19151919 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
RPTOR PPARGC1A â—¼   SHARES_COMPLEX 22.0 1.0 ACSN 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
RPTOR PPARGC1A â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 12150925 12408816 12533512 12906785 15755954 16469695 17680028 18046414 18048642 18492954 19022819 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
RPTOR DEPTOR â—¼   ENZYMATIC_REACTION ✅ 35.0 1.0 ACSN 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18000759 18372248 18492954 19022819 19143636 19151919 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
RPTOR HIF1A â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 12150925 12777372 15755954 15854902 16469695 16915281 17991864 19299511 19864431 19942859 20484410 22025673 22841746 23087689 26159692
RPTOR SQSTM1 â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 12150925 12777372 15340068 15755954 15854902 16252010 16469695 17991864 19299511 19864431 19942859 20484410 20531300 21981924 22025673 23087689 25002027 26159692 26587781 28574505
RPTOR DEPTOR â—¼   DOWN_REGULATES ✅ - 35.0 1.0 ACSN 11274345 11756498 12150925 12408816 12906785 15749884 15755954 16469695 16713974 17404308 17604271 17680028 18000759 18372248 18492954 19022819 19143636 19151919 19446321 19568798 19706736 19864431 20547845 20805416 21157483 21981924 22504639 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
RHEB RPTOR â—¼   UP_REGULATES ✅ 7.0 1.0 ACSN 12906785 16636147 17604271 18466115 19022819 19143635 23087689
RRAGC RPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 21816923 25561175 20006481 18497260 24337580 25446900 21981924
PRKAA1 RPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 21460634 18439900
RHEB RPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 17604271 15854902 19299511 16636147 24337580 15878852 17470430 19143635 16631613 12906785 18466115 25446900
AKT1S1 RPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 17604271 17510057 18030348 17386266 18215133 17517883 33230243
PRKAA2 RPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 18220336 19369195 18722121 18439900 20083114 19413330 18669648
PRKAB1 RPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 18220336 19369195 21460634 18722121 18439900 19413330 18669648
EIF4EBP1 RPTOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 40.0 1.0 Omnipath 18337751 24403073 16824195 12665511 12747827 12604610 18606717 19272448 16837165 12150926 18955708 21071439 16798736 22493283 17502379 15066126 18722121 12912989 15767663
SQSTM1 DEPTOR â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 15340068 16252010 20531300 21981924 25002027 26587781 28574505
GABARAPL1 SQSTM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 17580304 20562859 23022382 21691068 25416956 31053714 16189514 32296183 21617041 19250911
GSK3B CDK6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 11152665 20537194 10385618 11124803 12969793 19757160 16732330 10486203 16039586 14536078 18167338 12459251 12615961
CCND2 CDK6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10477583 17517622 16713569
PRKAG1 PRKAA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 20562859 10698692 26186194 9224708 17012231 16054041 25416956 31515488 32296183
CAMKK2 PRKAA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 35.0 1.0 Omnipath 16051629 22561688 21228273 34044797 24959379 17244528 15980064 23716691 25065674 15465812 34421352 12413941 19197243 18692468 33502468 34216621 23863464 34064003 16054096 16054095 15509864 33675805 20538596 19958286 25937278 34290400 34253170 23612973 22304913
MAP3K7 PRKAA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16054096 16054095 15509864 19197243 17244528 18692468 15980064
PRKAA2 TSC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 18692468 16959574 19339977 14651849
PRKAA2 CRTC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 16308421 16148943 15454081 18626018 20577053 16817901
PRKAA2 ULK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21205641 19584320
PRKAA2 TSC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18692468 19339977 14651849
COX7C COX6C â—¼   PHYSICAL_INTERACTION 6.0 1.0 ACSN 11389896 15119951 16051147 17418790 19625251 8194600
COX7C COX6C â—¼   SHARES_COMPLEX 6.0 1.0 ACSN 11389896 15119951 16051147 17418790 19625251 8194600
TSC2 TSC1 â—¼   PHYSICAL_INTERACTION 31.0 1.0 ACSN 12150915 12172553 12869586 12906785 14551205 14651849 15342917 15611338 15851026 16556040 16636147 16678438 16959574 17604271 17680028 17693255 18198340 18481918 18692468 18974095 19022819 19027299 19339977 20146692 21533173 21621563 21708191 23030059 26597054 27328425 9069260
TSC2 TSC1 â—¼   PROTEIN_INTERACTION 31.0 1.0 ACSN 12150915 12172553 12869586 12906785 14551205 14651849 15342917 15611338 15851026 16556040 16636147 16678438 16959574 17604271 17680028 17693255 18198340 18481918 18692468 18974095 19022819 19027299 19339977 20146692 21533173 21621563 21708191 23030059 26597054 27328425 9069260
DAPK1 TSC2 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 11323415 17703233 18974095 19180116
TSC2 RHEB â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 12906785 16636147 17680028 19022819 20146692
TSC2 TSC1 â—¼   DOWN_REGULATES ✅ - 31.0 1.0 ACSN 12150915 12172553 12869586 12906785 14551205 14651849 15342917 15611338 15851026 16556040 16636147 16678438 16959574 17604271 17680028 17693255 18198340 18481918 18692468 18974095 19022819 19027299 19339977 20146692 21533173 21621563 21708191 23030059 26597054 27328425 9069260
PRKAB1 TSC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18692468 19339977 14651849
GSK3B TSC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 24795562 12511557 23265840 15972957 16959574 22980037 22732551
PRKAA1 TSC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 19339977 33271062 14651849 16959574 15261145 28591720 18692468 20363874
AKT2 TSC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 12150915 12167664 12172553 19188143
DAPK1 TSC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18974095
TSC2 RHEB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 15340059 15854902 23331499 16636147 12869586 17680028 21071413 20146692 12771962 20226003 12906785 12842888
TSC2 TSC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 84.0 1.0 Omnipath 12167664 16424383 12511557 21134130 14551205 10915759 11741832 15340059 20166753 23331499 15342917 9580671 21071413 16464865 15851026 11290735 9809973 15851513 12869586 10807585 15963462 10585443 11741833 20412061 20226003 11175345 25263562 16339216 18411301 16636147 14651849 17658474 17693255 12176984 17077083
STAT1 JAK3 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 11418623 12517932 12244150 27774606 12093291 12759422
JAK1 STAT1 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 10426994 11907067 12244150 12811837 15536084 16081783 16713974 16785506 19833085 20856220 21840487 23124025 24751819 7512720 7521688
IL4R STAT1 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10485906 11867689 12223527 12401408 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26755705 27216177 7512720 7521688 7543512 9535722
STAT1 FGF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16494848 23086340 19556344
STAT1 IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 8683127 24242046 23675777 19703987 7619083 18616672 24012417 20693420
JAK3 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 23109003 11406370 12495636 17277783 9535918
JAK1 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 132.0 1.0 Omnipath 35317858 11839738 10918587 15261459 34950606 11306517 8756628 12244150 8156998 9535918 10748192 7657660 12817007 23257612 27774606 25297818 22306691 8631301 7510216 14963018 15284024 24243840 7592750 10851062 11823427 23331499 7532278 11418623 11722592 18988627 12637327 27387064 8662591 10022928 19088846 32953130 7796299 7504784 23124025 19787091 24058793 20169197 7543024 15322115 18941194 19534553 15978943 14978237 11294897 14764663 21429244 14565860 34228987 25386349 18989459 34521819 9020188 19535621 10982844 21576360 12759422 18508557 8232552 12093291 12040185 20006573 8662795 7690989 20087684 11438544 20035788 11972023 29145629 9355737 11152457 12517932 18389480
RICTOR MAPKAP1 â—¼   PHYSICAL_INTERACTION 45.0 1.0 ACSN 10722653 11274345 11756498 12408816 12906785 15718470 16469695 16556040 16678438 17461779 17680028 18000759 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19151919 19203586 19446321 19568798 19706736 19720745 20027184 20338997 21157483 21474067 21533173 21621563 21708191 21981924 22475393 22924465 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
DEPTOR MAPKAP1 â—¼   PHYSICAL_INTERACTION 25.0 1.0 ACSN 11274345 11756498 12408816 12906785 16469695 17461779 17680028 18000759 18492954 19022819 19143635 19151919 19446321 19568798 19706736 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
MAPKAP1 PRR5 â—¼   PHYSICAL_INTERACTION 18.0 1.0 ACSN 12408816 12906785 16469695 17680028 18492954 18566586 19022819 19143635 19568798 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
DEPTOR MAPKAP1 â—¼   SHARES_COMPLEX 25.0 1.0 ACSN 11274345 11756498 12408816 12906785 16469695 17461779 17680028 18000759 18492954 19022819 19143635 19151919 19446321 19568798 19706736 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
RICTOR MAPKAP1 â—¼   SHARES_COMPLEX 45.0 1.0 ACSN 10722653 11274345 11756498 12408816 12906785 15718470 16469695 16556040 16678438 17461779 17680028 18000759 18481918 18492954 18566586 18570873 18925875 19022819 19027299 19143635 19151919 19203586 19446321 19568798 19706736 19720745 20027184 20338997 21157483 21474067 21533173 21621563 21708191 21981924 22475393 22924465 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9069260
MAPKAP1 PRR5 â—¼   SHARES_COMPLEX 18.0 1.0 ACSN 12408816 12906785 16469695 17680028 18492954 18566586 19022819 19143635 19568798 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
RICTOR PRR5 â—¼   PHYSICAL_INTERACTION 18.0 1.0 ACSN 12408816 12906785 16469695 17680028 18492954 18566586 19022819 19143635 19568798 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
RICTOR DEPTOR â—¼   PHYSICAL_INTERACTION 25.0 1.0 ACSN 11274345 11756498 12408816 12906785 16469695 17461779 17680028 18000759 18492954 19022819 19143635 19151919 19446321 19568798 19706736 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
RICTOR DEPTOR â—¼   SHARES_COMPLEX 25.0 1.0 ACSN 11274345 11756498 12408816 12906785 16469695 17461779 17680028 18000759 18492954 19022819 19143635 19151919 19446321 19568798 19706736 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025
RICTOR PRR5 â—¼   SHARES_COMPLEX 18.0 1.0 ACSN 12408816 12906785 16469695 17680028 18492954 18566586 19022819 19143635 19568798 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 28216025
MAP3K7 MAP2K3 â—¼   ENZYMATIC_REACTION ✅ 25.0 1.0 ACSN 10391247 11280761 11460167 11477091 12620219 14633987 14660645 15082531 15125833 16603398 16799562 17301840 17363905 18264787 18641653 19161412 20164171 21041997 21133840 21232017 22941947 23681101 24403530 24699077 24958845
MAP3K7 IL2RA â—¼   ENZYMATIC_REACTION ✅ 26.0 1.0 ACSN 10391247 11280761 11460167 12620219 14633987 14660645 15082531 15125833 15282297 16200688 16603398 16799562 17301840 17363905 18264787 18641653 19161412 20060931 20164171 21041997 21133840 21232017 22941947 24403530 24699077 24958845
MAP3K7 MAP2K3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17299140 21902831 23331499 8663074 12791976
MAP3K7 PRKAG2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16054096 16054095 15509864 19197243 17244528 18692468 15980064
MAP3K7 PRKAA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 16054096 16054095 15509864 19197243 17244528 20615388 18692468 15980064
MAP3K7 PRKAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16054096 16054095 15509864 19197243 17244528 18692468 15980064
JAK1 IL2RA â—¼   PHYSICAL_INTERACTION 26.0 1.0 ACSN 10807786 10820393 10849428 12095053 15289500 15563472 16212621 16799562 17371980 1825141 18758473 19528259 19833085 20856220 21840487 22224781 23124025 23650441 24829413 26755705 2965306 6164929 7512720 7521688 8683106 9625766
JAK1 IL6 â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
JAK1 IL4R â—¼   PHYSICAL_INTERACTION 40.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 1825141 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26755705 27216177 2965306 7512720 7521688 7543512 9535722 9834059
JAK1 IL4R â—¼   SHARES_COMPLEX 40.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 1825141 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26755705 27216177 2965306 7512720 7521688 7543512 9535722 9834059
JAK1 IL6 â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
JAK1 IL2RA â—¼   SHARES_COMPLEX 26.0 1.0 ACSN 10807786 10820393 10849428 12095053 15289500 15563472 16212621 16799562 17371980 1825141 18758473 19528259 19833085 20856220 21840487 22224781 23124025 23650441 24829413 26755705 2965306 6164929 7512720 7521688 8683106 9625766
JAK1 IL6 â—¼   ENZYMATIC_REACTION ✅ 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
JAK1 IL4R â—¼   ENZYMATIC_REACTION ✅ 40.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 1825141 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26755705 27216177 2965306 7512720 7521688 7543512 9535722 9834059
JAK1 IRS2 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23390297 24030977 24091328 27216177 2965306 7512720 7521688 9834059
IL4R JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 11127821 23331499 12704343 12133952 17312100 23124025 7929391 12223527
JAK3 JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 11641425 19901323 20135364 17259970 12207328 10825200 11909529 15659558 12559972 9553136
JAK1 IRS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11591769 9233603 7499365
JAK1 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 15001544 11591769 8756628 7544789 9305869 11162588 9233603 15592455 7499365 12220227
HIF1A IL6 â—¼   ENZYMATIC_REACTION ✅ 21.0 1.0 ACSN 10804084 15749903 16110315 16127144 16243976 16413922 17485448 17533374 20427344 20535745 20855962 21051947 21765015 22006996 22850421 22988108 24006507 25043024 25103413 25732824 9743347
HIF1A IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17548584 20003295 21258402 15913932 18791496
EIF4E HIF1A â—¼   UP_REGULATES ✅ + 16.0 1.0 ACSN 10403805 11566883 12080085 12829734 13130303 15451019 15563472 16887934 1823643 7539918 8943284 9155017 9159130 9278421 9746763 9878069
EIF4EBP1 EIF4E â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 111.0 1.0 Omnipath 24211447 24722188 35044719 16824195 18957614 8521827 25416956 11553333 10405182 22509910 11605658 17254965 16271312 17689282 22586265 16648488 16467844 12747827 16242075 10772338 12604610 12867426 12747804 10330171 21798997 12482586 16189514 15550948 21191102 12071973 10406811 18955708 12105188 20224576 17353931 26186194 8816458 17316564 15094042 10753870 16798736 10022874 32296183 19834456 10698949 15153109 15661536 11146653 12588975 16504179 10394359 7935836 7651417 22678294 20880835 10364159 23584478 15767663
FN1 ITGA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 9117345 9842903 19738201 11010812
LAMC1 ITGA6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 7721947 10671376 11733063 32196115
FN1 ITGB7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 1372909
PRKAA1 PPARGC1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20640476 17609368
AKT2 PPARGC1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 21297943 17554339
RHEB BNIP3 â—¼   PHYSICAL_INTERACTION 6.0 1.0 ACSN 12906785 17928295 18466115 19022819 19143635 23087689
RHEB FKBP8 â—¼   PHYSICAL_INTERACTION 6.0 1.0 ACSN 12906785 17991864 18466115 19022819 19143635 23087689
RHEB DEPTOR â—¼   PHYSICAL_INTERACTION 22.0 1.0 ACSN 12150925 12408816 12906785 15755954 16469695 17680028 18466115 18492954 19022819 19143635 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26597054 28216025
RHEB FKBP8 â—¼   PROTEIN_INTERACTION 6.0 1.0 ACSN 12906785 17991864 18466115 19022819 19143635 23087689
RHEB BNIP3 â—¼   PROTEIN_INTERACTION 6.0 1.0 ACSN 12906785 17928295 18466115 19022819 19143635 23087689
RHEB DEPTOR â—¼   SHARES_COMPLEX 22.0 1.0 ACSN 12150925 12408816 12906785 15755954 16469695 17680028 18466115 18492954 19022819 19143635 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26597054 28216025
TSC1 RHEB â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 12906785 14551205 16636147 17604271 17680028 17693255 19022819 20146692
RHEB DEPTOR â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 12150925 12408816 12906785 15755954 16469695 17680028 18466115 18492954 19022819 19143635 19568798 19864431 21157483 21981924 23087689 24795729 24973821 25002027 25730849 26159692 26597054 28216025
TSC1 RHEB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 17604271 16636147 20006481 17680028 20146692 14551205 17693255
BNIP3 RHEB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 19136941 17928295
RHEB FKBP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 18676370 18658153 17991864 19222999
RHEB AKT1S1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17604271 17510057 16636147 12820960 12869586 17386266 19446321 19143635 17277771 18466115
RHEB BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 19651622 20166139 16803888 18691976 20068231 18452278 12214276 15150271 18669648
DAPK1 TSC1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 11323415 17703233 18974095 19180116
DAPK1 CAMKK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 18691976 15209507
IL4R IRS2 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23390297 24030977 24091328 27216177 2965306 7512720 7521688 9834059
IL4R IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9697832 8124718 8599766 12704343
IL4R JAK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 17312100 12207328 7538655
IL4R IRS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 8954948 12704343 8266078 10233717
BRAF YWHAB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 17145710 12620389 17353931 24255178 15324660 10931830
DVL3 FZD1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
GSK3B FZD1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
HIF1A BNIP3 â—¼   ENZYMATIC_REACTION ✅ 66.0 1.0 ACSN 10102273 10428030 10428780 10435632 10804084 10823814 11557773 11559532 11744734 11756417 11884613 12402042 12676992 12743597 14672622 14684737 14699081 14762718 15024076 15059920 15199147 15240700 15312748 15369676 15379897 15545625 16110315 16126909 16127144 16517405 16517406 16585195 16782875 16888645 17143338 17418790 17533374 17785433 18054315 18056423 18158893 18718909 19211554 20028863 20427344 20535745 20855962 21051947 21765015 22006996 22841746 22850421 22988108 24006507 25043024 25103413 25732824 7493931 7500013 7508926 8089148 8702901 8955077 9486205 9525945 9707622
HIF1A FGF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19492421 16399861 17536272 17942638
HIF1A INS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14612449 11457733 18752464 17878221
HIF1A BNIP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 20864819 17848618 11559532 20332243 19745228 17513511 11550088 10922063 12879018
HIF1A FLT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 7539918 1823643 12829734 9159130 13130303 9746763 12080085 11566883 10403805 8943284 15451019 11528470 9278421 16887934 9295307
HIF1A BNIP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16585195 19136941 18054315 11559532
PDPK1 AKT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 35.0 1.0 Omnipath 15743829 15191648 10679787 23331499 19203586 15718470 26491696 26937223 9374542 24169049 15890450 28589878 9512493 12048203 10822383 12434148 20059950 11134526
PDPK1 MAP2K2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15175348 15466476
PDPK1 ITGB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 18578522 10896934
ITGA11 IGF2 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 17420280 17600088 19913614 20129924 25076207 26148229
EGF ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15748904 23331499 12093292 11279155
FN1 ITGB6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 1694173 18480047 1532572 17015452
MAPK9 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 11160134 9335553 12417588 14579029
JAK3 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 7544789 9233603 7499365
INS IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 25309812 25472611 23891856 20150288 29069585 24036112 21518983 11160134 19357636 22198320 17579213 21677282 11684411 23983791 28955049 25760026 21850561 22832498 19808019 22698915 23815272 18443205 20601126 16150913 25383313 27695421 23115649 22728334 19752148 19171749 27819676 16516141 22418434 19542202 25381390 22516431 24763529 26866272 23695665 23431498
FN1 ITGB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 11423542 1694173 18480047 1532572 8663002 17015452
GSK3B CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 11152665 20537194 10385618 11124803 12969793 19757160 16732330 10486203 16039586 14536078 18167338 12459251 12615961
CCND2 CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 25910212 17517622 27107012 11896535 10477583 9325318 31515488 16189514 32296183
FN1 ITGA9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11839764
JAK3 IRS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 7499365
INS AKT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 20338882 25304263 30179516 23832510 23801578 22307032 20041157 24725432
EIF3I EIF3A â—¼   PROTEIN_INTERACTION 1.0 1.0 HIPPIE 28514442 18599441 17353931 26344197 33961781 24981860 26186194 22939629 14519125 8995409
EIF3A EIF3C â—¼   PROTEIN_INTERACTION 1.0 1.0 HIPPIE 18599441 9822659 22863883 33961781 24981860 23623729 22939629 14519125 26344197
ATG4B GABARAPL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 20562859 19549685 14530254 20404487 32296183
GSK3B CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 17486076 11152665 20537194 10385618 11124803 12969793 19757160 16732330 10486203 16039586 14536078 18167338 12459251 12615961
BRAF LAMTOR2 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 21779496 9733512 12479806 15118098 17178906 15547943
BRAF LAMTOR3 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 21779496 9733512 12479806 15118098 17178906 15547943
BRAF MAP2K2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 23331499 15342917 18039929 19541618 7706312 15466476 25600339 7731720 16135787 17563371 33226073 8668348 17667937 16255777
MAP2K2 LAMTOR2 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 21779496 9733512 12479806 15118098 17178906 15547943
RRAGA RRAGC â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
MAP2K2 LAMTOR3 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 21779496 9733512 12479806 15118098 17178906 15547943
GSK3B DVL3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
AKT2 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 17145710 21303971 11882383 17680028 9065430 20214616 22094462 23552696 12434148 20398329 21506126 26051358 16293724 20028971 12040186 9712142 18218901
GSK3B EIF4EBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 23584478 17570479 27387559 18701453
AKT2 AKT1S1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 22.0 1.0 Omnipath 17329361 19651622 17081983 17386266 17517883 12524439 11352916 20068231 18372248 19413330 17277771 14973226 18669648 23682635
MAP2K3 MAPK13 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 23331499 11242034 21614932 12738796 11274345 9374491 18083107 9790884 18855897
PRKAA1 PRKAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 20562859 17145710 18480843 8626596 17728241 21232561 16306228 8663446 25852190 8621713 23455922
CAMKK2 PRKAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16054096 16054095 15509864 19197243 17244528 18692468 15980064
CAMKK2 PRKAB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16054096 16054095 15509864 19197243 17244528 18692468 15980064
CAMKK2 PRKAA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 14985505 21918180 8910387 16054096 16054095 15509864 19197243 14614828 23625915 17244528 18692468 15980064 14511394 23583109
PRKAA1 CRTC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 21892142 20577053
PRKAA1 ULK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 24820971 23372762 28295473 21460634 19584320 21205641 21258367 28389629 34421918 34224814 25980607 32978258
PRKAA1 LIPE â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 21338323 2165906 16188906 15033481 9636039 18398140
PRKAA1 RRN3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 28835357 19815529
MAPK9 RRN3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 15805466
ATG101 RB1CC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20562859 23392225 19597335
LAMC1 ITGB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 7721947 10671376 11733063 32196115
ULK1 RB1CC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 20562859 19225151 23392225 19597335 25686248 26118643 19211835
CAMKK2 PRKAG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 16054096 16054095 15509864 19197243 17244528 18692468 15980064
CAMKK2 PRKAG3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16054096 16054095 15509864 19197243 17244528 18692468 15980064
CAMKK2 PRKAG2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16054096 16054095 15509864 19197243 17244528 18692468 15980064
COL2A1 ITGA10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9685391