Protein list:

Seperate proteins by space | Example

Select nodes using shift click or drag to add to this list
Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
Graph tools:

Note this may take some time with > 30 proteins
Filter Graph:

0.5
Layout:
  🔂

Click a node or edge for more data...
Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
IRF3 BAX â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7900384 20360684
CAPN2 BAX â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 21887410 23242420
STAT3 BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17089128 20422978
BAX AIFM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12232790
VDAC1 BCL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0907555106 19706527
STAT5B BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16741510 18793823
TCF7L2 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17404573 23671559
STAT5A BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14695224 14500638
BCL2 MAPK8 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 15733859 5217553
HSP90AA1 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18266962
CAPN2 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12000759
STAT3 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11994401
CAPN1 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12000759
NFKB1 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11704864 11313951
CASP3 BID â—¼   CLEAVAGE ✅ 2.0 0.8 intact 0707715105 18723680
FAS BID â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15659383 25241761
FASLG BID â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15659383 25241761
FADD BID â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15659383 25241761
CAPN1 XIAP â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 19931333 28747251
CASP8 CASP3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18669646 0712034105
HTT CASP3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PARP1 CASP3 â—¼   CLEAVAGE ✅ 2.0 0.8 intact 7596430 376037
HTT CASP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16777606 10770929
CASP3 CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17899380
CASP3 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9500443
DDX41 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HMGB1 TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18218727 19158276
HSP90AA1 CHUK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSP90AA1 TRADD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSP90AA1 TRAF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSP90AA1 IKBKE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSP90AA1 RIPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSP90AA1 MAVS â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20628368 16394098
HSP90AA1 NFKBIB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSP90AA1 IKBKG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
STAT5B HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19014541 22552610
HSP90AA1 RIPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17145710 14743216
TRAF2 IKBKE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSP90AB1 IKBKE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
IKBKE STING1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0900850106 19433799
IKBKE CYLD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18636086 6804508
IRF3 IKBKE â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20304918 21182093
STAT3 IKBKE â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22330135
PARP1 IKBKG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSP90AB1 IKBKG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
SLC25A5 IKBKG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
SLC25A6 IKBKG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
RIPK1 IKBKG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10880512 5212735
TBK1 IKBKG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
CAMK2D IKBKG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
TNFAIP3 IKBKG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 11389905 5214127
CYLD IKBKG â—¼   DEUBIQUITINATION ✅ 2.0 0.8 Reactome 12917691 15620648
RNF31 IKBKG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24469399 21455180
FADD IKBKG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16227629 23131831
SQSTM1 IKBKG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16874300
TRAF2 IRF7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15361868 19479062
MAVS IRF7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15361868 19479062
IRF9 IRF7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10924517 12768031
STAT2 IRF7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10924517 12768031
IRF7 IFNA5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19349300 12242290
IRF7 IFNA7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10938111 19349300
IRF7 IFNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16410796
PARP1 IKBKB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
PARP1 TRAF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
PARP1 H2AZ1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1429884
MEFV PYCARD â—¼   COLOCALIZATION ✅ 0.8 0.8 mint 11498534 5214377
NLRP3 PYCARD â—¼   COLOCALIZATION 2.0 0.8 intact 5215008 11786556
NFKB1 SQSTM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9762895
IL6 STAT3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8662591 8662795
TCF7L2 STAT3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18602747
RELA STAT3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 25040843
STAT3 CCL5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17510282 20038813
STAT3 IL1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17386941 31886314
STAT3 BIRC3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16048438
STAT3 IFNAR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18550668
TNF CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21887257 19287455
H2AC4 TNFRSF1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
SLC25A5 TNFRSF1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
SLC25A6 TNFRSF1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
CASP7 TNFRSF1A â—¼   COLOCALIZATION 2.0 0.8 intact 8095238 21157428
TNFRSF1A CASP8 â—¼   COLOCALIZATION 2.0 0.8 intact 8095238 21157428
XIAP CASP7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6547707 9525868
IRF3 IFNA7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19349300 12821121
IRF3 IFNA14 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19349300 11303025
IRF3 TBK1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 18583960 6948053
IRF3 TBK1 â—¼   COLOCALIZATION 2.0 0.8 intact 17599067 5220070
STING1 IRF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22394562 18818105
RBCK1 IRF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18711448
IRF3 CCL5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11991981
IRF3 CXCL10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12354379
IRF3 IFNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16410796
PCBP1 ALOX15 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20884783
HTT CHMP2A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HTT FTL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
FADD FAS â—¼   COLOCALIZATION 2.0 0.8 intact 16498403 5218359
SLC25A5 NFKBIA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
NFKBIB NFKBIA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
CHUK NFKBIA â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 12799363 23430059
IFNB1 STAT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10022928 18508557
TYK2 STAT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15261459 23124025
IL6 STAT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8662591 8662795
STAT1 IFNAR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 9121453 6730748
STAT1 IFNAR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 9121453 6730748
STAT1 CAMK2G â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
STAT1 CAMK2A â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
STAT1 CAMK2B â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
STAT1 CAMK2D â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
RELA STAT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 25040843
STAT1 TLR3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16628196
IFNAR2 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11301323 9121453
STAT6 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 28430601 10982806
STAT1 FASLG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12108949
STAT1 FAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17992189
MAP3K7 IKBKB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219785 17363973
MAP3K7 SHARPIN â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16260783 16953224
MAP3K7 RNF31 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16260783 16953224
TLR3 MAP3K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12609980 16115877
CYLD MAP3K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 29291351 18332137
HSP90AB1 RIPK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
SLC25A5 RIPK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
TNFAIP3 RIPK1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 19131965 20599425
CYLD RIPK1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 19131965 23010170
CYLD RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17981138 19131965
RIPK1 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18949366 24323043
RIPK1 IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21119000 18362886
HSP90AB1 TRAF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
SLC25A5 TRAF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
SPATA2 TRAF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
TRAF2 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TRAF2 CHMP2B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
TRAF2 TBK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
TRAF2 BIRC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
TRAF2 MAPK9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16713569 10490605
JAK1 CAMK2D â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
JAK1 CAMK2B â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
JAK1 CAMK2G â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
JAK1 CAMK2A â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
STAT6 JAK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22254182 17433443
IFNGR2 JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15120645 23331499
IFNB1 JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 10918594
RBCK1 RNF31 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
IFNGR1 IFNG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 376230 7617032
IFNGR1 CAMK2B â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
IFNGR1 CAMK2A â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
IFNGR1 CAMK2G â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
IFNGR1 CAMK2D â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
IFNAR1 IFNGR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18929502 23331499
IFNG CAMK2B â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
IFNG CAMK2D â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
IFNG CAMK2G â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
IFNG CAMK2A â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
STAT2 IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9218597 21178011
G3BP1 JAK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217568 15743820
JAK2 STAT6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15261459 23124025
JAK2 CAMK2A â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
JAK2 CAMK2G â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
JAK2 CAMK2B â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
JAK2 CAMK2D â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
STAT5B JAK2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17255200 11682625
TYK2 STAT6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15261459 23124025
IFNB1 TYK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 10542297
TYK2 EIF2AK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23236554 17290288
NFKBIB CCL5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15609310 24383830
RIPK3 GLUD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19632174 19498109
RIPK3 GLUL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19498109
RIPK3 PYGL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19632174 21903422
SLC25A5 RIPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSP90AB1 RIPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
AIFM1 RIPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
TICAM1 RIPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15064760
ZBP1 RIPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 32200799 19590578
MAPK8 FASLG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15659383 25241761
MAPK8 CFLAR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18471544
SMPD1 CASP8 â—¼   COLOCALIZATION 2.0 0.8 intact 8095238 21157428
CASP8 TNFSF10 â—¼   COLOCALIZATION 2.0 0.8 intact 23678861 8429107
IL1B CASP8 â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 1574116 22267217
MAVS CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16406812 21419663
BIRC2 CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17145710 12887920
CASP8 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11002417
CASP8 IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11002417
NFKBIB CHUK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSP90AB1 CHUK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
CHUK IKBKB â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 12799363 23430059
CHUK HSP90AB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
CHUK IKBKB â—¼   PROTEIN_INTERACTION 2.0 0.8 ACSN 12799363 23430059
RELA IKBKB â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 12842894 5216511
TRAF3 TRADD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8565075 5220916
SLC25A6 TRADD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
SLC25A5 TRADD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSP90AB1 TRADD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
AIFM1 TRADD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
TNFAIP3 TRADD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12654725
NFKBIB IL1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1905804 20975042
IL1B CASP1 â—¼   CLEAVAGE ✅ 2.0 0.8 intact 0812690106 19439663
IFNGR2 CAMK2D â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
IFNGR2 CAMK2B â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
IFNGR2 CAMK2G â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
IFNGR2 CAMK2A â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
NFKB1 TNFRSF10A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21243522
NFKB1 BIRC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9294162 9733516
TRAF3 BIRC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18997792 18997794
BIRC3 BIRC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23070005 18485876
MAVS CYLD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18636086 6804508
TBK1 CYLD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18636086 6804508
TNFAIP3 TICAM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217223 15474016
HSP90AB1 IKBKB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
IKBKB EIF2AK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10848580 16600570
TRAF3 BIRC3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18997792 18997794
JAK3 STAT6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12207328 26758199
HSP90AB1 NLRP3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 29712950 17435760
MAVS NLRP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 25816776 24048902
G3BP1 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CHMP4B HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PLA2G4C HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ZBP1 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CHMP1A HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CASP7 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
VDAC2 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SPATA2L HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HTT SPATA2L â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HTT VPS4B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
G3BP1 EIF2AK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 25784705 25520508
HSP90AB1 MAVS â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20628368 16394098
HSP90AB1 NFKBIB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
MAPK8 STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19737086
ZBP1 TBK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17618271
POLR1D POLR1C â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
POLR1C NFKBIB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
POLR3G POLR3F â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20154270 0914980107
POLR1D NFKBIB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
POLR2L NFKBIB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
POLR2H NFKBIB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
STAT5A JAK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8709637 7489741
STAT5B JAK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8709637 7489741
IRF9 IFNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7843405 20038197
CAMK2D CAMK2B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20668654 1000426
MEFV CASP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16785446 0602081103
CASP1 CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18667412
VDAC3 VDAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
VDAC3 VDAC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H2AC11 IL33 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6802671 18688256
CHMP4A CHMP5 â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
MAPK8 MAPK9 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
TICAM1 TRAF3 â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
CHMP1A CHMP5 â—¼   PHYSICAL_INTERACTION 810.0 0.81 STRING 36370105
TRAF2 TRAF3 â—¼   PHYSICAL_INTERACTION 811.0 0.81 STRING 36370105
POLR3E POLR3GL â—¼   PHYSICAL_INTERACTION 811.0 0.81 STRING 36370105
IKBKG MAVS â—¼   PHYSICAL_INTERACTION 812.0 0.81 STRING 36370105
XIAP CASP3 â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 9525868 6547707
SHARPIN IKBKG â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 23032186 8410237
PYGM PYGB â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 32296183 33961781
CTBP1 H2AX â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34133714 31041561
VDAC1 AIFM1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 29128334
BIRC3 CTBP2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 32553630 30948266
MAVS CYLD â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 18636086 30410068
CHMP5 CHMP3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
PPIA DNM1L â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 29128334 26496610
IFNA4 IFNA2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
IFNA4 IFNA8 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
IFNA4 IFNA7 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
JAK1 STAT5A â—¼   PHYSICAL_INTERACTION 823.0 0.82 STRING 36370105
POLR2L POLR3B â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
TNFRSF1A TRAF2 â—¼   UP_REGULATES ✅ + 0.82 0.82 Signor 10795740
CASP3 PARP1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 19549685 32223133 8642305 7596430 19713971 22451931 17167422 9875225 18723680
PYGB PYGL â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 25910212 25416956 32296183 33961781
BIRC2 XIAP â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 17069460 16263936 33961781 22711539
XIAP AIFM1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 17967870 22103349
IFNA5 IFNA6 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
FADD RIPK3 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 19524513 22864571 27560715 30420664 26786097 21052097
RIPK1 CYLD â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 17981138 21408173 33654169 22848449 28900035
RIPK1 TRAF5 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 29955050 11479302
SHARPIN RBCK1 â—¼   PHYSICAL_INTERACTION ✅ 0.83 0.83 mint 23032186 8410237
BIRC2 RNF31 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 24726327 30561431 27545878 23524849
RNF31 CYLD â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28189684 27591049 27545878 27458237 27307491 26670046
CASP8 RIPK3 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 19524512 30420664 22864571 19524513
CYLD FAS â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 27591049 31067453 31762063
TRADD TRAF3 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 8565075 30561431
CASP1 IL1B â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 7797510 28147281 8999548 32122970 7642516 1919001 19439663
VPS4B BIRC2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
TRAF3 BIRC2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 20097753 30561431 33608556 23524849
MAVS TRAF5 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 27348524 31806368 20161788 31390091 26221961
IFNA2 IFNA5 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
VDAC1 VDAC2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 31536960 22939629 29128334
IFNA5 IFNA4 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
CHUK NFKBIB â—¼   PHYSICAL_INTERACTION 830.0 0.83 STRING 36370105
CHMP1B VPS4B â—¼   PHYSICAL_INTERACTION 832.0 0.83 STRING 36370105
CASP1 GSDMD â—¼   PHYSICAL_INTERACTION 832.0 0.83 STRING 36370105
POLR2F POLR3B â—¼   PHYSICAL_INTERACTION 833.0 0.83 STRING 36370105
POLR2F POLR3C â—¼   PHYSICAL_INTERACTION 834.0 0.83 STRING 36370105
RELA STAT3 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
MAP3K7 RIPK1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
OTULIN SHARPIN â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
JAK3 STAT5A â—¼   PHOSPHORYLATION ✅ + 0.83 0.83 Signor 18250158
IFNAR2 STAT2 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
NFKBIA IKBKG â—¼   PHOSPHORYLATION ✅ 0.84 0.84 mint 8209688 16126728 506093200
IKBKG NFKBIA â—¼   PHOSPHORYLATION ✅ 0.84 0.84 mint 8209688 16126728 506093200
TNF RIPK1 â—¼   PHYSICAL_INTERACTION ✅ 0.84 0.84 mint 23815148 8432069
TRAF2 TRAF3 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 9718306 30561431 15383523 21903422
JAK1 TYK2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 8702790 7589562
TRAF3 BIRC3 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 20097753 33608556 23524849 23612708
CYLD RIPK1 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
MAVS TRAF5 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
HTT SQSTM1 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
CHMP4A VPS4A â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
RNF31 IKBKG â—¼   POLYUBIQUITINATION ✅ + 0.84 0.84 Signor 24469399
JAK2 STAT5B â—¼   PHOSPHORYLATION ✅ + 0.84 0.84 Signor 9575217
CYLD RNF31 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
IKBKB NFKB1 â—¼   PHOSPHORYLATION ✅ - 0.84 0.84 Signor 11158290
JAK2 STAT5A â—¼   PHOSPHORYLATION ✅ + 0.84 0.84 Signor 9575217
CHMP1A CHMP4B â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
STAT3 STAT1 â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 6730629 8662591
CYLD TRAF2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 27591049 12917691 23405219 28900035
TRAF5 TRAF2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 9718306 32296183 21903422
CFLAR TRAF2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 16189514 16713569 9208847 32313199 10837247
AIFM1 PGAM5 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 34079125 27218139 29568061
HSP90AA1 PPID â—¼   PHYSICAL_INTERACTION 850.0 0.85 STRING 36370105
CHMP2A CHMP5 â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
CHMP2B CHMP4B â—¼   PHYSICAL_INTERACTION 853.0 0.85 STRING 36370105
PYGB PYGL â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
CHMP4B VPS4A â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
CHUK RELA â—¼   PHOSPHORYLATION ✅ + 0.85 0.85 Signor 10521409
SLC25A4 SLC25A5 â—¼   PHYSICAL_INTERACTION 858.0 0.85 STRING 36370105
CASP8 BCL2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16183855 11406564
PYCARD CASP1 â—¼   PHYSICAL_INTERACTION ✅ 0.86 0.86 mint 34589402
CHMP2A VPS4A â—¼   PHYSICAL_INTERACTION 859.0 0.86 STRING 36370105
JAK1 STAT1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 32123171 11722592 34521819 32953130 11294897 10982844 15322115 12637327 7690989 14978237 15284024 10918587 7543024 32814877 12817007 34950606 7657660 11839738
RIPK3 TRAF2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16713569 10339433
TLR4 TRAF3 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 32802180 21903422
CHMP2A VPS4B â—¼   PHYSICAL_INTERACTION 861.0 0.86 STRING 36370105
BIRC2 CASP8 â—¼   PHYSICAL_INTERACTION 861.0 0.86 STRING 36370105
SPATA2 TNFRSF1A â—¼   PHYSICAL_INTERACTION 862.0 0.86 STRING 36370105
RBCK1 TNFRSF1A â—¼   PHYSICAL_INTERACTION 864.0 0.86 STRING 36370105
MEFV PYCARD â—¼   PHYSICAL_INTERACTION 865.0 0.86 STRING 36370105
TICAM1 TICAM2 â—¼   PHYSICAL_INTERACTION 865.0 0.86 STRING 36370105
IKBKE TNF â—¼   PHYSICAL_INTERACTION 866.0 0.86 STRING 36370105
BAX VDAC1 â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
IKBKG RELA â—¼   PHOSPHORYLATION ✅ + 0.86 0.86 Signor 15489227
CASP8 BID â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 9727492 15659383 9727491 12097160 11832478 12196516 11085743
CASP3 BID â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 10364179 11399776 18723680
CASP8 CASP3 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 15254227 11832478 18669646 11437602 8962078
BIRC3 CASP3 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 17069460 9384571
PARP1 NFKB1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 16204234 11590148 25609649 16799643
IRF3 MAVS â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 16153868 22908223 25636800 24379373 21903422
JAK2 STAT1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 11294897 15322115 11152457 12637327 7690989 20353823 19834108 14978237 15284024 10918587 24255956 7543024 12817007 7657660 11839738
CASP8 BIRC2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 12887920 27810922 15069192 22274400
CASP8 TRADD â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 19524513 18776134 17047155 12887920 29108854 30561431
VDAC2 VDAC3 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 31536960 22939629 30021884
IKBKE TBK1 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
CASP8 TRAF2 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
FAS FASLG â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
POLR3E POLR3G â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
POLR3D POLR3G â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
CASP8 FASLG â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
CFLAR TNFSF10 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
IKBKE MAVS â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
MAP3K7 TNFRSF1A â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
CHUK MAP3K7 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
IFNAR1 STAT2 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
IKBKG SHARPIN â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
AIM2 PYCARD â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
BIRC2 TNF â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
BIRC2 TNFRSF1A â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
IFNGR1 STAT1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
MAVS TRAF2 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
OTULIN RBCK1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
BIRC2 IKBKG â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
MAP3K7 TRAF2 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
TRAF3 TRAF5 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
POLR1C POLR2K â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
IKBKE IRF3 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
IFNA14 IFNA6 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
NFKBIA NFKBIB â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
POLR3G POLR3H â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
IRF3 MAVS â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
IKBKB TRAF2 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
BIRC2 TRAF2 â—¼   UBIQUITINATION ✅ - 0.87 0.87 Signor 20651737
CASP8 RIPK3 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
CHUK RELA â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
NFKB1 NFKBIB â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
CAMK2D CAMK2G â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
PARP1 HMGB1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 29721183 28190768 34079125
IKBKE TRAF3 â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
IRF7 IRF3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 18641315 11162841
BIRC2 XIAP â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
FADD TNFRSF10A â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
FADD TNFRSF10B â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
CFLAR RIPK1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 17047155 21737330 11002417 10837247 26972597
RIPK1 TRAF3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 8612133 32296183
CASP8 TRAF2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 23142077 22179575 17047155 28972304 12887920 16227629 21282461 11340079 30054040
MLKL RIPK3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 27560715 29883609 22265413 31358971 30420664 24316671 22265414
CASP8 TRADD â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
TBK1 CYLD â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 18636086 25923723 29755980
TBK1 MAVS â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 23028469 16153868 32366851 28346439 21813773 29125880 32511263 24643253 25636800 33372174 21903422 29743353
VPS4A VPS4B â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
CASP7 BIRC3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16339151 30948266 9384571
IKBKG TNFRSF1A â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
CHUK TRAF2 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
TBK1 TICAM1 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
CASP3 PARP1 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
CYLD IKBKG â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
TNF TNFAIP3 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
IKBKB RELA â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
CTBP1 CTBP2 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
IKBKG TBK1 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
STAT1 STAT3 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
RBCK1 TNF â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
MAVS TBK1 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
IKBKG RBCK1 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
IKBKG TNFAIP3 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
NLRP3 PYCARD â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
CHUK TNFRSF1A â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
TICAM2 TLR4 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
POLR1C POLR3K â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
JAK2 STAT3 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
SHARPIN TNF â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
CHMP1A VPS4B â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
CHMP2A CHMP2B â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
POLR3F POLR3G â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
JAK1 STAT3 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
JAK2 STAT1 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
VDAC1 BAX â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 9843949 16189514 15637055 28760928 12767928
BIRC2 CASP3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16189514 17069460 9384571 11084335 19258326 11106668
HSP90AA1 HSP90AB1 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
H2AX PARP1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 16377563 20000738 27728808 33961781 28796254 18406329 28242625 16522924 20085707
JAK2 STAT3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10925297 11294897 15156153 30413785 15284024 11350938 12626508 12576423 11940572 10918587 12244095 8626374 9211920 19834108 26775640 14551213 27351213 23838182
RIPK1 FADD â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11854271 23972990 24098568 33469115 11002422 26733177 19524513 26865630 32296183 22864571 27560715 23744296 32024820 21183682 30561431 21052097 19373245 24577083 21458669 21737329 32707033 21525013 22848449 29497034 33961781 26186194 26972597 21620750
STAT2 STAT1 â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 24065129
BIRC2 RIPK1 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
RIPK1 TNFAIP3 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
TRADD RIPK1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 8612133 24735611 27768232 21724995 16603398 30561431 23429285
RIPK1 BIRC2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 26612615 21931591 27197231 29021293 19854138 23972990 18570872 30561431 21113135 29955050
RIPK1 BIRC3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 21931591 23972990 33526051 18570872 21113135 16547522
MAVS TRAF2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 32296183 27348524 16153868 31806368 30527812 29125880 33582548 32877691 26221961 21516116 31390091 30561431 21903422
CTBP2 CTBP1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 31041561 16189514 25416956 16713569 21988832 28947780 30585266 26496610 33961781 35016035 26186194 24722188 27107012 9858600 26344197
CASP7 BIRC2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16189514 16339151 9384571 11084335 33961781 15580265 19258326
TRAF3 TBK1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 22330071 32324863 29125880 27135603 22792062 23986588 20174559 22079989 22908223 33608556 28049150 32779804 24763515 33372174 24622840 23717208 19380580 23308279 34084167 17991829 29920243 33187908 26928339 33411856 31404116
TRAF3 TRAF5 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 32296183 25241761 9718306 15383523 21903422
VDAC1 VDAC3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 31536960 22939629 29128334 30021884
CHMP1B CHMP3 â—¼   PHYSICAL_INTERACTION 891.0 0.89 STRING 36370105
IKBKG TNF â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
CASP8 BID â—¼   CLEAVAGE ✅ + 0.89 0.89 Signor 9727492
IKBKB TNFRSF1A â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
NFKBIB RELA â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
POLR2F POLR3H â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
TNF TRAF2 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
FADD TNFSF10 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
IKBKB MAP3K7 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
TBK1 TRAF2 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
BAX BID â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 25241761 15574335 20956295 23374347 17289999
CAPN1 BAX â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 19931333 21887410 23242420
CTBP1 BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12676992 7834749 15613549
CFLAR CASP3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 9208847 9326610
CASP3 XIAP â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 16189514 25241761 11447297 9525868 11257230 19698783 9384571 22815893 15507451 16869888 17291493 15200957 27927753 19273858 18723680 16543147 23074197 11927604 18521960 30522111 23979166 17069460 12624662 15650747 11257232 11359776 33961781 26186194 22072751 9230442
CASP3 NFKBIA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9367996 29752472
HSP90AA1 MLKL â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 26866270 26775703 26933192
STAT3 HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9880553 10440232 23228483
TNFAIP3 IKBKE â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18353649 15661910
IKBKG IKBKB â—¼   PHOSPHORYLATION ✅ 3.0 0.9 intact 8209688 506093200 16126728
IKBKG RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15489227
NFKB1 IL1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17513725 17612514
CASP1 IL1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18329368
IRF3 IRF7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20483755 15367631 15664995
MAVS IRF7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17020950 16153868
NFKB1 STAT3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12057007 25241761 16713569
STAT3 FAS â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15223310 22313388 16651438
IFNG STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10707961 11960596 28264935
STAT3 HSP90AB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18266962 12559950
STAT4 TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17339437 18802110 14707106
CASP7 XIAP â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 14512414 16189514 15200957 23979166 31467278 9525868 11257230 19698783 11257232 11257231 9384571 11359776 27927753 23074197 33961781 15580265 18521960 9230442
XIAP MAP3K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11865055 12048196
IRF3 TBK1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 23028469 31534043 25636800 16394098 30267576 21903422 22079989 15695821 32241891 20628368 18636086 15841462 19380580 28346439 18583960 25803835 17599067 12692549 19153231 22388039 24807708 19656901 22072751
IRF3 IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20483755 27337441
IRF3 TBK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23843640 20304918 18636086
POLR2L POLR3C â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
NFKB1 CCL4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18270204 11342414
TNFRSF10B FADD â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12721308 17327223 10894160
IFNG STAT1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12040185 7796299 8156998
IFNGR2 STAT1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12040185 7796299 8156998
STAT2 STAT1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 8621447 8605877 28514442 26966684 10446176 31836668 17923090 10490982 9724754 24065129 15825084 35140242 33961781 12048190
STAT1 IRF9 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 17923090 8943351 24065129
STAT1 JAK2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12223098 21239533
STAT1 STAT2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16918696 19122651
STAT1 IRF9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22951020
STAT1 IL1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17386941 23922745
CAMK2B STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17502367
MAPK9 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14963018
STAT1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16481475
CASP8 RIPK1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 27810922 23972990 24098568 33052227 14681455 19773432 33469115 18485876 22274400 26733177 19524513 22864571 29431638 25939870 19524512 11002417 18570872 29021293 27552911 29274253 22179575 22173242 19373245 25911380 22585859 21737330 24577083 21458669 21282461 21737329 20825417 19060883 32707033 21525013 23429285 10521396 17047155 12887920 23955153 26972597 12215447 12884866
RIPK3 RIPK1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 24098568 31358971 30420664 21903422 19524513 22864571 23744296 22817896 29883609 22265413 19524512 26786097 10339433 25882049 26319693 22265414 29352166 26559832 29497034
RIPK1 TRAF2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 25416956 24735611 23972990 16603398 8612133 32296183 16291755 11181075 19815541 24434549 30561431 21810480 11479302 31502302 27768232 20577214 25716317 21282461 25882049 8702708 9020361 16713569 29352166 23007157
TNFRSF10A RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9430227
TNFRSF10B RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9430227
TRAF2 TRADD â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 14743216 9020361 32296183 16713569 11479302 11181075 19815541 10892748 12796506 27768232 23955153 8702708 32968279 8565075 30561431 23429285 10911999
IL6 JAK1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 8134389 8272873 9382798
IRF9 IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8864350 22252317 9218597
STAT5B IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15528362 12759422
TYK2 STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 9872990
TYK2 STAT4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 16324152
CASP8 CFLAR â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 22322857 24438025 12097160 33469115 19416807 22864571 9208847 9326610 17159907 11741985 15280356 19710364 21737330 31046799 21737329 9289491 17047155 9228018 12887920 9380701 33961781 26186194 12215447 19343040
CASP8 TNFSF10 â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
TBK1 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10783893 21138416
PPID SLC25A4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14729611 12149099 15033717
RELA TNFRSF10A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12615723 21243522
RELA IL18 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10227974 17399992 15963597
RELA TNFAIP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11880364 19343319 10807933
NFKB1 IL18 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10227974 17399992 15963597
CASP1 IL18 â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 1574116 9121587 8999548
STAT6 STAT4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19324016 17032631 11359632
TLR4 TICAM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22664090 14519765 19656901
TRADD BIRC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8943045 12887920
STAT2 IRF9 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 8943351 17923090 24065129 33961781 9242679 21903422
JAK3 STAT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23109003 11406370 12495636
NFKB1 BIRC2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 21725609 23178297 23572150
NFKB1 TNFSF10 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20542572 21243522 11544302
NFKB1 TNFAIP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11880364 19343319 10807933
CAMK2A CYLD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24614225
CAMK2B CYLD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24614225
TNFAIP3 TICAM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15474016
TNFAIP3 TBK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18353649 15661910
TRAF3 TICAM1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16306937 19898473 16306936
TRAF3 TICAM2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16306937 19898473 16306936
TRAF3 MAVS â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16858409 16306936 17190786
JAK3 STAT5B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23109003 11406370 12495636
CASP1 IL33 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19439663 16286016
STAT5B STAT5A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15043997 17997837 14532269
STAT5A IFNA13 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8683106 9831114 7796811
STAT5A STAT5B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21542777 15043997 17997837
POLR3C POLR3K â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
VPS4A CHMP2A â—¼   CLEAVAGE ✅ + 0.9 0.9 Signor 30989108
CASP8 TNFRSF10A â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
BAX BID â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
BCL2 BID â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
CFLAR FADD â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
BIRC3 TRAF2 â—¼   UBIQUITINATION ✅ - 0.9 0.9 Signor 18997794
RNF31 TNF â—¼   PHYSICAL_INTERACTION 905.0 0.9 STRING 36370105
CASP8 RIPK1 â—¼   CLEAVAGE ✅ - 0.9 0.9 Signor 10521396
POLR3C POLR3G â—¼   PHYSICAL_INTERACTION 0.9 0.9 HuRI 32296183
TRAF2 RIPK1 â—¼   UP_REGULATES ✅ + 0.9 0.9 Signor 10795740
TRAF2 RIPK1 â—¼   UBIQUITINATION ✅ + 0.9 0.9 Signor 18621737
TYK2 IFNAR1 â—¼   PHOSPHORYLATION ✅ + 0.9 0.9 Signor 8605876
POLR3E POLR3K â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
IKBKG RNF31 â—¼   PHYSICAL_INTERACTION 909.0 0.91 STRING 36370105
POLR1D POLR3C â—¼   PHYSICAL_INTERACTION 909.0 0.91 STRING 36370105
TNFSF10 FADD â—¼   PHYSICAL_INTERACTION ✅ 0.91 0.91 mint 10894160 5212774
FAS CASP8 â—¼   PHYSICAL_INTERACTION ✅ 0.91 0.91 mint 11717445 5214823
CASP8 FAS â—¼   COLOCALIZATION ✅ 0.91 0.91 mint 5219431 17159907
FAS CASP8 â—¼   COLOCALIZATION ✅ 0.91 0.91 mint 16498403 5218359
MLKL RIPK3 â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
CASP8 TNFRSF10B â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
JAK3 STAT5A â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
POLR2F POLR3D â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
CHMP2B VPS4B â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
POLR3C POLR3GL â—¼   PHYSICAL_INTERACTION 0.91 0.91 HuRI 32296183
IRF3 TBK1 â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
IRF9 STAT2 â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
TNFRSF1A TRADD â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
TBK1 IRF3 â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 17599067 5220070
TBK1 IRF3 â—¼   PHOSPHORYLATION ✅ 0.92 0.92 mint 6948053 18583960
TBK1 IRF3 â—¼   COLOCALIZATION ✅ 0.92 0.92 mint 17599067 5220070
STAT1 STAT4 â—¼   PROTEIN_INTERACTION 0.92 0.92 HIPPIE 21826217 35140242 33961781
BIRC2 TRAF2 â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
TNFSF10 CASP8 â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 10894160 5212774
TNFSF10 CASP8 â—¼   COLOCALIZATION ✅ 0.92 0.92 mint 8429107 23678861
IKBKG RIPK1 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
CASP8 RIPK1 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
RIPK1 TRAF2 â—¼   PHYSICAL_INTERACTION 921.0 0.92 STRING 36370105
TNFRSF1A TRAF2 â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
POLR2F POLR3F â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
CASP8 FAS â—¼   PHYSICAL_INTERACTION 924.0 0.92 STRING 36370105
MAVS TRAF3 â—¼   PHYSICAL_INTERACTION 924.0 0.92 STRING 36370105
CHMP4B CHMP5 â—¼   PHYSICAL_INTERACTION 924.0 0.92 STRING 36370105
JAK2 STAT5B â—¼   PHYSICAL_INTERACTION 926.0 0.92 STRING 36370105
POLR2F POLR3K â—¼   PHYSICAL_INTERACTION 928.0 0.92 STRING 36370105
FTL FTH1 â—¼   PHYSICAL_INTERACTION ✅ 0.93 0.93 mint 8153045 21516116
CHMP1B VPS4A â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
CHMP1B CHMP5 â—¼   PHYSICAL_INTERACTION 931.0 0.93 STRING 36370105
POLR2L POLR3A â—¼   PHYSICAL_INTERACTION 933.0 0.93 STRING 36370105
CHMP1A CHMP2A â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
POLR2H POLR3F â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
CHMP1B CHMP4B â—¼   PHYSICAL_INTERACTION 938.0 0.93 STRING 36370105
VPS4B VPS4A â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 28514442 11563910 12594041 33961781 26186194
XIAP CASP3 â—¼   UBIQUITINATION ✅ - 0.94 0.94 Signor 11447297
TBK1 TRAF3 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
POLR3A POLR3K â—¼   PHYSICAL_INTERACTION 942.0 0.94 STRING 36370105
CHMP4B CHMP6 â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
IFNAR1 IFNAR2 â—¼   PHYSICAL_INTERACTION 944.0 0.94 STRING 36370105
CHMP6 VPS4A â—¼   PHYSICAL_INTERACTION 945.0 0.94 STRING 36370105
POLR2H POLR3D â—¼   PHYSICAL_INTERACTION 945.0 0.94 STRING 36370105
SHARPIN RNF31 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 23032186 8410237
TRAF3 MAVS â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 27348524 27980081 32366851 32324863 29125880 22792062 22022264 30267576 22079989 31806368 20080758 21200404 22908223 30527812 33608556 31390091 26221961 24622840 16858409 33582548 19419966 22901541 32511263 19893624 26519536 23545497 33411856
TNFSF10 TNFRSF10B â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 5211930 10542098
POLR2L POLR3D â—¼   PHYSICAL_INTERACTION 955.0 0.95 STRING 36370105
CAMK2A CAMK2B â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
POLR1C POLR3E â—¼   PHYSICAL_INTERACTION 958.0 0.95 STRING 36370105
FAS FADD â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 5219431 17159907
TRADD FADD â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 24686082 32296183 12107169 12796506 8681376 21724995 12911633 23955153 11112409 16919273 8565075 30561431 10911999
FAS FADD â—¼   COLOCALIZATION ✅ 0.96 0.96 mint 16498403 5218359
TBK1 TRAF2 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 14743216 32707033 20449947 20562859 29125880 23007157 27135603 30420664 33961781 10990461 30561431 21903422 32041822
POLR3F POLR3K â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
POLR2F POLR3A â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
CAMK2B CAMK2D â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
JAK2 STAT5A â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
IKBKB NFKB1 â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
POLR3D POLR3K â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
CHUK NFKB1 â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
IFNA2 IFNAR1 â—¼   PHYSICAL_INTERACTION 967.0 0.96 STRING 36370105
JAK1 STAT3 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 11722592 15284024 11294897 8272872 11751884 11350938 12626508 12576423 11940572 10918587 12244095 8626374 9566874 25065853 31462771 14551213
FADD CFLAR â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 16189514 22322857 9208847 9228018 9326610 17047155 27321185 21737330 14637155 29497034 33469115 20829884 26972597
NFKBIA IKBKB â—¼   PHOSPHORYLATION ✅ 0.97 0.97 mint 8209688 16126728 506093200
TRAF2 BIRC2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 16189514 25241761 10753917 21988832 19506082 9384571 8943045 19584093 16263936 21903422 32296183 11181075 19815541 20562859 8643514 15861135 16891304 16282325 30561431 8548810 30359437 11907583 20184394 21331077 25716317 25882049 23524849 27534557 25681446 21653699 16713569 20447407 23007157 20348096 33961781 24276241
TRAF2 BIRC3 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 25241761 30948266 10753917 21988832 9384571 20385093 19815541 20562859 8643514 16891304 16282325 24464131 8548810 11907583 21331077 27534557 23524849 15310755 23543740 16713569 23007157 33961781
CAMK2A CAMK2D â—¼   PHYSICAL_INTERACTION 969.0 0.97 STRING 36370105
CHMP2A CHMP3 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
CHMP3 CHMP4B â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
IFNAR1 TYK2 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
POLR2H POLR3B â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
POLR1D POLR3H â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
IFNA2 IFNAR2 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
POLR3C POLR3D â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
POLR1D POLR3D â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
TNFRSF10A TNFSF10 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
POLR3B POLR3K â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
POLR1D POLR3F â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
CASP1 PYCARD â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
POLR1D POLR2L â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
IKBKG IKBKB â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 5219009 16938294
IKBKB IKBKG â—¼   PHOSPHORYLATION ✅ 0.98 0.98 mint 8209688 16126728 506093200
POLR3B POLR3C â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
POLR2H POLR3C â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
CASP8 FADD â—¼   COLOCALIZATION ✅ 0.98 0.98 mint 5219431 17159907
RNF31 RBCK1 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 5219147 17006537
POLR3B POLR3F â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
POLR3A POLR3F â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
POLR1D POLR2H â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
TNFAIP3 TNFRSF1A â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
CHMP2A CHMP4B â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
TRADD TRAF2 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
OTULIN RNF31 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
POLR2E POLR3E â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
BAX BCL2 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
CASP8 CFLAR â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
TNFRSF10B TNFSF10 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
POLR3F POLR3H â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
POLR2F POLR2H â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
POLR2E POLR3C â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
POLR1D POLR2E â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
POLR2E POLR3B â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
POLR1C POLR2H â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
CASP3 XIAP â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
POLR3A POLR3C â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
BIRC3 TRAF2 â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
POLR3D POLR3F â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
CASP7 XIAP â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
POLR1C POLR3D â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
POLR2F POLR2L â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
POLR2K POLR2L â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
POLR2H POLR3H â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
NFKB1 NFKBIA â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
CHMP1A VPS4A â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
POLR1C POLR2F â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
BAX BCL2 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 21778226 18981409 15899854 32064756 10620799 21199865 17289999 9194558 8358790 21671007 16642033 21458670 22262057 9388232 10716992 20865015 14980220 9111042 24141421 17097560 15231068 9463381 33961781 17525735 29749471 23479509 26004684
BID BCL2 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 16697956 15694340 19074266 11583631 9727491 9463381 15520201 14681455 17289999 18835031 12624108
STAT1 STAT3 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 16007122 11722592 16189514 25241761 28514442 26966684 8662591 11594781 31462771 35140242 33961781 25609649 12070153
POLR1C POLR3C â—¼   PHYSICAL_INTERACTION 989.0 0.99 STRING 36370105
FADD CASP8 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 21785459 23142077 21988832 23972990 17290218 24098568 14681455 20103630 33469115 18485876 22274400 22864571 25043603 27560715 25939870 29795330 19524512 17159907 30561431 27552911 19176810 15659383 9343261 22179575 22173242 25911380 27321185 8681376 15280356 21737330 26437781 31046799 21458669 12702723 11717445 21737329 19060883 21525013 23429285 20448643 12107169 17047155 9228018 12887920 29497034 12911633 14612908 23955153 33961781 20829884 26972597 21620750
POLR3A POLR3D â—¼   PHYSICAL_INTERACTION 989.0 0.99 STRING 36370105
POLR1C POLR2L â—¼   PHYSICAL_INTERACTION 989.0 0.99 STRING 36370105
POLR3C POLR3H â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
POLR2E POLR3F â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
POLR3E POLR3H â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
POLR3D POLR3H â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
POLR3C POLR3F â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
POLR3C POLR3E â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
POLR1C POLR2E â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
POLR2E POLR3A â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
POLR2E POLR3K â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
POLR2E POLR3D â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
POLR2E POLR3H â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
POLR3A POLR3B â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
POLR1C POLR3B â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
POLR1D POLR3B â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
POLR3B POLR3H â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
POLR3B POLR3D â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
POLR3B POLR3E â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
POLR3A POLR3E â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
POLR3E POLR3F â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
POLR2H POLR3A â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
POLR1C POLR3A â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
POLR1D POLR3A â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
POLR3A POLR3H â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
POLR1C POLR3H â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
POLR1C POLR1D â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
POLR3D POLR3E â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
POLR1C POLR3F â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
IKBKG NFKBIA â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
FADD RIPK1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
CHUK NFKBIA â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
IKBKB NFKBIA â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
CHUK IKBKG â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
IKBKB IKBKG â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
NFKBIA RELA â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
POLR2E POLR2F â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
POLR2E POLR2H â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
POLR2E POLR2K â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
POLR2E POLR2L â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
POLR2F POLR2K â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
POLR2H POLR2L â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
POLR2H POLR2K â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
BCL2 BAX â—¼   PHYSICAL_INTERACTION 15.0 1.0 ACSN 11704864 16227588 17446862 17891140 20709625 21641962 22039431 23064052 23377657 23430059 23850759 7644501 8358790 8929532 9872359
BAX TRAF2 â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 20709625 21641962 22039431 23064052 23377657 23430059 23850759 26587781 7644501 8358790
BCL2 BAX â—¼   PROTEIN_INTERACTION 15.0 1.0 ACSN 11704864 16227588 17446862 17891140 20709625 21641962 22039431 23064052 23377657 23430059 23850759 7644501 8358790 8929532 9872359
BAX TRAF2 â—¼   PROTEIN_INTERACTION 10.0 1.0 ACSN 20709625 21641962 22039431 23064052 23377657 23430059 23850759 26587781 7644501 8358790
PYCARD BAX â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 14730312 19062087 19104081 19968986 26885855 27048821 27066895 27984721
BAX TRAF2 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 20709625 21641962 22039431 23064052 23377657 23430059 23850759 26587781 7644501 8358790
NFKB1 BAX â—¼   DOWN_REGULATES ✅ - 6.0 1.0 ACSN 12676992 15613549 21725609 23178297 23572150 7834749
STAT1 BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17346710 19801665 20567883
RELA BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18034190 18158998 20056115
BID BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 20956295 17289999 25241761 19968986 15574335 10629050 19062087 10949027 12242151 23374347 14730312 17520191 8918887
MAPK8 BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15525785 18471544 16709574
CAPN1 BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 20709625 21670566 21414921 16129881 17593948 14612448 21266584
PYCARD BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16964285 19062087 14730312 19968986
BCL2 BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 60.0 1.0 Omnipath 17145710 22705850 18981409 9463381 21458670 17097560 17525735 8358790 10620799 26004684 29749471 9388232 21199865 17525161 22262057 21778226 15486085 17289999 9111042 12419244 9194558 15231068 10716992 8183370 14980220 9115213 21671007 16642033 23479509 10677502
BAX VDAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 16189514 10365962 9843949 12767928
NFKB1 BCL2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 11313951 11704864 21725609 23178297 23572150
BCL2 TRAF2 â—¼   DOWN_REGULATES ✅ - 8.0 1.0 ACSN 11704864 17446862 22039431 23064052 23377657 23430059 23850759 8929532
NFKB1 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 16254192 11567031 17673602 18031796 12835724 15120608 20332461 14978135 20446017 18566231 19259124 14739605 21503108 20103608 17098279 18158998 12032828 19233129 16022909 18761399 18987666 15934930 21224428 16453001
RELA BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 17673602 18031796 12835724 15120608 20332461 14978135 20446017 18566231 19259124 14739605 21503108 20103608 17098279 18158998 19233129 16022909 18761399 18191642 21224428 16453001
STAT3 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 12400004 15805299 20514402 15184887 17997399 18320073 20880395 17089128 20446017 20422978 18981713 21344490 19287190 19103760 20043094 16144938 20233902 21172343 18839277 14523036 10626893 19926637 21435102 22504301 11431352 21385902 22313388 16048438 22984561
CASP3 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 10409669 9395403 20139069 11948397
MAPK8 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 45.0 1.0 Omnipath 12421819 26609913 17097560 16738310 21726807 10567572 21993018 29950132 20919655 22848813 15225643 19029119 9738012 18570871 9115213 12039864 11323415 15733859 18471544 15703383 23329792 10677502
BCL2 CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 16183855 11406564
BCL2 BID â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 18835031 17145710 9463381 16697956 17289999 19074266 12624108 11583631 9727491 15520201 8918887
CAPN2 BID â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 11404357 11940658 17264306 18469004 21887410 23242420
CAPN1 BID â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 11404357 11940658 17264306 18469004 19931333
MAPK8 BID â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 18594987 25326334 25077544 27374471
CAPN2 BID â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 18469004 12000759 20709625 17264306 21670566 11404357 21738214 16129881 17593948 21266584 11940658
CASP3 BID â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9727492 10364179 10805722 11832478 11085742 11085743
CASP8 BID â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 9727492 10364179 10805722 11832478 12196516 18458084 9727491 11085742 11085743 12097160 9873064
CASP1 BID â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11085743 9727491
CAPN1 BID â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 18469004 12000759 20709625 17264306 21670566 11404357 21738214 16129881 17593948 16189514 21266584 11940658
CAPN1 AIFM1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 11404357 11940658 17264306 18469004 19931333
XIAP CAPN2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 11583623 12815069 12835328 21887410 23242420
BIRC3 CASP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 9990849 12042762 9384571 17069460
BIRC2 CASP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 9990849 12042762 9384571 17069460 11382748 11106668 16189514 11084335
CASP8 CASP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 15755874 17179148 9501089 9950028 18669646 23308069 10988287 18458084 16964285 9885230 9765224 11437602 15014070 21295084 8962078 9208847
XIAP CASP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 70.0 1.0 Omnipath 23074197 16543147 22072751 12624662 18521960 22815893 11157976 15650747 15200957 11927604 11230124 9384571 16869888 9545235 23979166 18723680 16189514 11359776 15507451 9230442 19273858 26186194 10508158 25241761 12529384 19559631 11257230 12874265 9525868 17291493 11583623 11257232 17069460 12181739 10548111 11447297 15014070 19698783
CASP3 PARP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 11907276 8090205 7596430 9875225 32223133 10438458 17167422 7774019
CASP3 IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 9367996 11741536
IFNG HMGB1 â—¼   ENZYMATIC_REACTION ✅ 31.0 1.0 ACSN 10485906 11489965 11579131 11777960 11870632 11964313 12413632 12818165 14607900 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 1825141 18272812 19833085 20038811 20819927 21149606 21411734 24658051 26755705 2965306 6425450 9834059 9864217
TNF HMGB1 â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10925299 11112697 11438547 11875494 12646658 12811837 1431106 14607933 14625680 15099563 15699106 16713974 17916596 18633355 19411070 20038811 20184663 20435894 21133840 21411734 21826665 22595692 22955274 23170255 23430059 23508573 23510023 23567181 23769623 24092389 24378531 26201938 8910423
IL18 HMGB1 â—¼   ENZYMATIC_REACTION ✅ 21.0 1.0 ACSN 10679398 10952726 11592085 11672593 12646658 12803886 14504095 14662834 15099563 15802534 16267105 16327802 19931333 21372296 22842346 26618107 26885855 27048821 27066895 27192565 9469432
HMGB1 CCL4 â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 10952726 11672593 12646658 12803886 15802534 16267105 16327802 19931333 21372296 22842346 26618107 27048821 27192565
HMGB1 TLR4 â—¼   DOWN_REGULATES ✅ - 13.0 1.0 ACSN 10952726 11672593 12646658 12803886 15802534 16267105 16327802 19931333 21372296 22842346 26618107 27048821 27192565
HMGB1 TLR4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20547845 23519706 16267105 20348922
NFKB1 HSP90AA1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 17724475 21725609 23178297 23572150
STAT1 HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 9880553 21430289 12940076 10440232
STAT3 HSP90AA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 18266962 16189514 12559950
HSP90AA1 RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10744744 17145710 12441346 14743216
TLR4 IKBKE â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 12692549 15210742 14530355 17526488 17047224 14703513 19656901 17823124 23453971
TLR3 IKBKE â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 12692549 15210742 16306936 16281057 14530355 17526488 17047224 14703513 23453971
TRAF3 IKBKE â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 12692549 15210742 16306936 16281057 14530355 17526488 17047224 14703513 23453971
IKBKE TICAM2 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 12692549 15210742 14530355 17526488 17047224 14703513 19656901 17823124 23453971
IKBKE TICAM1 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 12692549 15210742 16306936 16281057 14530355 17526488 17047224 14703513 23453971
MAVS IKBKE â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 17145710 15210743 16127453 19153231 17020950 25636800 15210742 16306936 12702806 16177806 27419230 36056146 19546225 19380491 16858409 21200404 24706939 18207245 17468758 17327220
TICAM1 IKBKE â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 14739303 16410796 12692549 16281057
TBK1 IKBKE â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17599067 16177806 15210742 15210743 16306936 16127453 17468758 12702806 18353649 17327220 16858409
TRAF3 IKBKE â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 16177806 15210742 15210743 16306936 16127453 17468758 12702806 17327220 16858409 24763515
IKBKE IRF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 16127453 19153231 12692549 24722368 15210742 20532218 12702806 16380379 14703513 29800227 14679297 17706453 24396068 18440553 16281057 16625202 9463386 18818105 16199137 9566918 15695821 14739303 21138416 17526488 15212693 16914100
IKBKE IRF7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 16625202 25225665 9786932 15210742 22787218 10893229 26712804 16127453 12702806 16380379 15367631 12692549 17706453 16199137 16914100
IKBKE CYLD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 19287453 18636086 27844253 20863366 19481526 29755980
IKBKE STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 24065129 17502367 24416652 29186193 24058806 22520844
IKBKE TBK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17599067 16177806 15210742 15210743 16306936 16127453 17468758 12702806 17327220 24622840 16858409
IKBKE RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 28317833 12842894 16046471 20188669 15128824 17561400 17003035 30223576 15485852 10521409 15489227 15849198 16407239 26025205 15212693 12767944
IKBKE NFKBIA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 31.0 1.0 Omnipath 10783893 18794072 8657102 8601309 15939554 12138192 10329681 10882136 9721103 12403772 21171089 16888014 15879144 20717897 16007147 7796813 11815618 10421793 25133483 21872579 10398585 16199137
TICAM1 IKBKG â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15064760 15814722 16115877 16603398 16547522
TLR3 IKBKG â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15064760 15814722 16115877 16603398 16547522
TLR4 IKBKG â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15064760 15814722 16115877 16603398 16547522
TICAM2 IKBKG â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15064760 15814722 16115877 16603398 16547522
IKBKG CHUK â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 11340079 12133805 12799363 15199157 15485931 16818229 17363905 17485448 17693255 18716620 20138012 20300203 20531300 21217011 22435554 23430059 28462531
IKBKG CHUK â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 11340079 12133805 12799363 15199157 15485931 16818229 17363905 17485448 17693255 18716620 20138012 20300203 20531300 21217011 22435554 23430059 28462531
RELA IKBKG â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 9315679 9914500 9721103 10593898 9135156
NFKBIB IKBKG â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 9315679 9914500 9721103 10593898 9135156
NFKBIA IKBKG â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 9315679 9914500 9721103 10593898 9135156
TRAF2 IKBKG â—¼   ENZYMATIC_REACTION ✅ 84.0 1.0 ACSN 10542212 10754326 10820262 10925299 10952726 11112697 11274345 11280761 11438547 11460167 11875494 12133805 12433365 12646658 12811837 12907458 1431106 14607933 14625680 14660645 15099563 15199157 15465827 15485931 15536066 15592525 15644117 15699106 15749903 16243976 16413922 16713974 16818229 16878026 16970925 17237376 17254973 17301840 17363905 17404308 17462996 17485448 17693255 17916596 18264787 18345002 18633355 18641653 18716620 19392652 19411070 20038811 20138012 20184663 20300203 20435894 21133840 21217011 21232017 21411734 21807870 21826665 22435554 22955274 23086447 23170255 23390297 23422957 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 2649237 28462531 7594497 8910423 9743347
NFKB1 IKBKG â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 9315679 9914500 9721103 10593898 9135156
MAP3K7 IKBKG â—¼   ENZYMATIC_REACTION ✅ 25.0 1.0 ACSN 10391247 11280761 11460167 11477091 12620219 14633987 14660645 15082531 15125833 16603398 16799562 17301840 17363905 18264787 18641653 19161412 20164171 21041997 21133840 21232017 22941947 23681101 24403530 24699077 24958845
TRADD IKBKG â—¼   ENZYMATIC_REACTION ✅ 57.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
RNF31 IKBKG â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 11280761 11460167 14660645 17301840 18264787 21133840 21232017 24699077 24958845
FADD IKBKG â—¼   ENZYMATIC_REACTION ✅ 57.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
RIPK1 IKBKG â—¼   ENZYMATIC_REACTION ✅ 57.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
TNF IKBKG â—¼   ENZYMATIC_REACTION ✅ 84.0 1.0 ACSN 10542212 10754326 10820262 10925299 10952726 11112697 11274345 11280761 11438547 11460167 11875494 12133805 12433365 12646658 12811837 12907458 1431106 14607933 14625680 14660645 15099563 15199157 15465827 15485931 15536066 15592525 15644117 15699106 15749903 16243976 16413922 16713974 16818229 16878026 16970925 17237376 17254973 17301840 17363905 17404308 17462996 17485448 17693255 17916596 18264787 18345002 18633355 18641653 18716620 19392652 19411070 20038811 20138012 20184663 20300203 20435894 21133840 21217011 21232017 21411734 21807870 21826665 22435554 22955274 23086447 23170255 23390297 23422957 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 2649237 28462531 7594497 8910423 9743347
RBCK1 IKBKG â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 11280761 11460167 14660645 17301840 18264787 21133840 21232017 24699077 24958845
SHARPIN IKBKG â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 11280761 11460167 14660645 17301840 18264787 21133840 21232017 24699077 24958845
IKBKG NFKBIA â—¼   ENZYMATIC_REACTION ✅ 17.0 1.0 ACSN 11340079 12133805 12799363 15199157 15485931 16818229 17363905 17485448 17693255 18716620 20138012 20300203 20531300 21217011 22435554 23430059 28462531
IKBKG RELA â—¼   ENZYMATIC_REACTION ✅ 38.0 1.0 ACSN 11280761 11438547 11460167 12133805 12811837 14660645 15145317 15199157 15485931 15536066 15573129 16818229 16970925 17237376 17254973 17301840 17363905 17485448 17693255 18264787 18716620 19833085 20138012 20300203 21133840 21217011 21232017 21807870 22435554 23086447 23422957 23430059 24378531 24699077 24766893 24958845 2649237 28462531
TRAF2 IKBKG â—¼   DOWN_REGULATES ✅ - 84.0 1.0 ACSN 10542212 10754326 10820262 10925299 10952726 11112697 11274345 11280761 11438547 11460167 11875494 12133805 12433365 12646658 12811837 12907458 1431106 14607933 14625680 14660645 15099563 15199157 15465827 15485931 15536066 15592525 15644117 15699106 15749903 16243976 16413922 16713974 16818229 16878026 16970925 17237376 17254973 17301840 17363905 17404308 17462996 17485448 17693255 17916596 18264787 18345002 18633355 18641653 18716620 19392652 19411070 20038811 20138012 20184663 20300203 20435894 21133840 21217011 21232017 21411734 21807870 21826665 22435554 22955274 23086447 23170255 23390297 23422957 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 2649237 28462531 7594497 8910423 9743347
TNF IKBKG â—¼   DOWN_REGULATES ✅ - 84.0 1.0 ACSN 10542212 10754326 10820262 10925299 10952726 11112697 11274345 11280761 11438547 11460167 11875494 12133805 12433365 12646658 12811837 12907458 1431106 14607933 14625680 14660645 15099563 15199157 15465827 15485931 15536066 15592525 15644117 15699106 15749903 16243976 16413922 16713974 16818229 16878026 16970925 17237376 17254973 17301840 17363905 17404308 17462996 17485448 17693255 17916596 18264787 18345002 18633355 18641653 18716620 19392652 19411070 20038811 20138012 20184663 20300203 20435894 21133840 21217011 21232017 21411734 21807870 21826665 22435554 22955274 23086447 23170255 23390297 23422957 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 2649237 28462531 7594497 8910423 9743347
IKBKG IL6 â—¼   DOWN_REGULATES ✅ - 38.0 1.0 ACSN 10542212 10754326 10952726 11875494 12133805 12907458 14660645 15199157 15465827 15485931 15536066 15644117 15749903 16243976 16413922 16818229 16878026 16970925 17237376 17254973 17363905 17404308 17485448 17693255 18716620 20138012 20300203 21217011 21807870 22435554 23086447 23390297 23422957 23430059 2649237 28462531 7594497 9743347
IKBKG STAT1 â—¼   DOWN_REGULATES ✅ - 38.0 1.0 ACSN 11280761 11438547 11460167 12133805 12811837 14660645 15145317 15199157 15485931 15536066 15573129 16818229 16970925 17237376 17254973 17301840 17363905 17485448 17693255 18264787 18716620 19833085 20138012 20300203 21133840 21217011 21232017 21807870 22435554 23086447 23422957 23430059 24378531 24699077 24766893 24958845 2649237 28462531
NFKB1 IKBKG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14743216
MAP3K7 IKBKG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 50.0 1.0 Omnipath 24911653 11477091 17301840 18180283 19909372 15125833 24699077 17363905 16356855 18641653 24403530 18079694 18223652 14514672 17496917 19531477 20300203 11325957 21133840 21232017 18264787 9744859 10391247 16799562 15836773 10702308 23109003 12620219 14633987 17363973 19161412 22941947 23681101 17047224 29145629 11280761 16301747 15082531 26192618 14660645 20038579 24958845 15327770 20164171 11460167 16603398 21041997
RIPK1 IKBKG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 10880512 21383699 21458669 14653779 10980203 17702576 9927690 16603398 16547522 16965765 10755617
TNFRSF1A IKBKG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16189514 10755617
BIRC2 IKBKG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 19223549 12867425 20301198
CYLD IKBKG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 21988832 15341735 15870263 22990857 12917689 12917691 16627981 20932475 26802121 12917690
TNFAIP3 IKBKG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 22.0 1.0 Omnipath 21988832 11389905 22099304 23032186 20932475 26802121 31585000 10755617
IKBKG NFKBIA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 17145710 7862124 11087742 10602462 16818647 8657102 16965765 22435544 11064457 24369075 10880512 7739562 14743216 16319058 7878466 16126728 10329646 15836773 16177806 21217772 16153868 10195894 12514169 18617513 15371334 16493424 17706453 15145317 10723801 15870263 7796813 17468758 16603398 17965022 11830587
IKBKG NFKBIB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17145710 15836773 14743216 15145317 17072322 10723801
IKBKG IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 150.0 1.0 Omnipath 17145710 16938294 20932476 35339487 18266324 16260493 27929056 25979343 19666608 26496610 12133833 12192055 9751060 21423167 19706536 15836773 17561400 22099304 23986494 19959994 15327770 25400026 24266532 18450452 12657630 20434986 11583588 20200955 20300203 21903422 22990857 14743216 20167598 20098747 16126728 19656241 25852190 16906147 10195894 17000764 18329793 16186825 16547522 16611882 18037881 10968790 16497931 25286246 18462684 18207244 16603398 17965022 17977820 24240172 17568778 15084594 16129692 23506214 16319058 23123196 18949366 15218526 22605335 20368414 10837071 19820708 10980203 23131831 17363973 15214841 25304104 16493424 15184390 15691841 11864612 15802604 17693255 21455180 11865184 20211142 11971985 16970925 24469399 24618592 12486103 11057907 24369075 19365808 18583959 27426725 12612076 19422324 10094049 23109003 21803029 12459277 21640763 16285893 18266467 12709429 15620648 17072322 19815509 15749833
IKBKG CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 74.0 1.0 Omnipath 17145710 17485448 16938294 11865184 11877453 16970925 22435554 17244613 17568778 17363905 16818229 15084594 15485931 24369075 20300203 21217011 12799363 23180781 14743216 16319058 21703539 19666608 20098747 12612076 16126728 15218526 23430059 9751060 20138012 18716620 20368414 10837071 25355947 15836773 23109003 20531300 17702576 17363973 15214841 12459277 17561400 21640763 16285893 28462531 12709429 10968790 15199157 26192618 12133805 16497931 11864612 17693255 17072322 11340079
IKBKG NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14743216
RELA IL1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 27371733 21131967 23195252 17612514 27076634 21106671
TLR4 IRF7 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 14517278 15210742 14703513 9566918 17823124 17157040
TRAF3 IRF7 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15210742 16281057 14703513 9566918 17157040
TLR3 IRF7 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15210742 16281057 14703513 9566918 17157040
TICAM2 IRF7 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 14517278 15210742 14703513 9566918 17823124 17157040
TICAM1 IRF7 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15210742 16281057 14703513 9566918 17157040
RELA IRF7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15265881 16982926 11877397
NFKB1 IRF7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15265881 16982926 11877397
STAT1 IRF7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 22951020 11877397 16628196 22252317 12768031 15767254 15664995
IRF7 IFNA14 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10938111 19349300 15699120 11303025
IRF7 IFNA13 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 21670437 10933732 12077266 11473119 17785777 9877175 10938111 19798431 11303025 12242290 16612387 16251417 21940674 15265881 12138184 16175599 19349300 10692430 27012395 11162841 17702615
IRF7 IFNA4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10938111 11884139 9786932 19557165 16014964 16380379 17785777 9877175 24185615 10692430
IRF7 IFNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 22547704 24532789 12604599 15355347 16186222 12915551 16014964 22065573 19176627 23906644 17785777 22698399 17236232 9877175 10938111 11303025 19557165 21994549 10848607 20637800 19349300 14729983 10692430 20581830 11846976 20483755 12821121 19570869
IRF7 CXCL10 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23405030 20483755 16253303 24701034
IRF7 IFNA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10938111 11473119 19349300 17236232 10692430
TBK1 IRF7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 16625202 17599067 9786932 15210742 22787218 26712804 16127453 12702806 15367631 12692549 16380379 17706453 16199137 16914100
CASP7 PARP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 9875225 1558065 16374543 11058599 9463409 11170436
PYCARD NLRP3 â—¼   PHYSICAL_INTERACTION 11.0 1.0 ACSN 11989976 17959595 19104081 20385749 23202296 23702978 26885855 27048821 27066895 27439607 27984721
PYCARD AIM2 â—¼   PHYSICAL_INTERACTION 6.0 1.0 ACSN 19104081 23702978 26885855 27048821 27066895 27984721
PYCARD AIM2 â—¼   PROTEIN_INTERACTION 6.0 1.0 ACSN 19104081 23702978 26885855 27048821 27066895 27984721
PYCARD NLRP3 â—¼   SHARES_COMPLEX 11.0 1.0 ACSN 11989976 17959595 19104081 20385749 23202296 23702978 26885855 27048821 27066895 27439607 27984721
PYCARD IL1B â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 19104081 20385749 23202296 26885855 27048821 27066895 27439607 27984721
PYCARD NLRP3 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11989976 17959595 19104081 20385749 23202296 23702978 26885855 27048821 27066895 27439607 27984721
PYCARD AIM2 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 19104081 23702978 26885855 27048821 27066895 27984721
CASP1 PYCARD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 24630722 25605870 12191486 15383541 11051551 11967258 11536016 24803432 21385879 26121674 11432859 12019269 16585594 19337385 14634131
MEFV PYCARD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 12054656 11498534 17964261 12646168 25006247 17431422 16037825 14595024
SQSTM1 FADD â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 12702723 15340068 16252010 16498403 20531300 21981924 23069999 25002027 26587781 28574505 9184224
SQSTM1 FAS â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 12702723 15340068 16252010 16498403 20531300 21981924 23069999 25002027 26587781 28574505 9184224
SQSTM1 FASLG â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 12702723 15340068 16252010 16498403 20531300 21981924 23069999 25002027 26587781 28574505 9184224
SQSTM1 RIPK1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 12702723 15340068 16252010 16498403 20531300 21981924 23069999 25002027 26587781 28574505 9184224
TBK1 SQSTM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 24818040 25040165 29147513 28655770 31810986 28871090 25505069 32966780 27846364 31444413 27404485 34996837 32835772 24886973 30223576 29930914 29973599 27005665 22921120 25723488 25972374 33084718
SQSTM1 RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 26416459 10356400 19850933
STAT3 STAT5B â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 23073628 15790786 11369651 15007386 12481435 15526160 28403213 10358045 28192400 17546049 9355737
STAT3 JAK3 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 11418623 12517932 12244150 27774606 12093291 12759422
STAT3 STAT5A â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 23073628 15790786 11369651 15007386 12481435 15526160 28403213 10358045 28192400 17546049 9355737
JAK1 STAT3 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 10426994 11907067 12244150 12811837 15536084 16081783 16713974 16785506 19833085 20856220 21840487 23124025 24751819 7512720 7521688
TYK2 STAT3 â—¼   ENZYMATIC_REACTION ✅ 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
IL6 STAT3 â—¼   ENZYMATIC_REACTION ✅ 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
JAK2 STAT3 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 11867689 14610620 19833085 20237318 20406969 20581311 21840487 22754783 24091328 27216177 7512720 7521688
STAT3 IL1B â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10347215 11875494 12193690 12223527 12907458 14607900 14670306 15218058 15356132 15465827 15573129 16418395 17404308 18776941 19380816 20093776 20237412 20406969 20435894 20580461 20581311 21372296 21765015 21840487 22461508 23124025 23390297 23454751 23953057 24857661 27216177 28186502 7543512
STAT3 IFNG â—¼   ENZYMATIC_REACTION ✅ 23.0 1.0 ACSN 10347215 12223527 14607900 14670306 15218058 15356132 15573129 16418395 18776941 19380816 20093776 20237412 20406969 20581311 21115385 21840487 23124025 23454751 23953057 24857661 27216177 28186502 7543512
STAT1 STAT3 â—¼   DOWN_REGULATES ✅ - 46.0 1.0 ACSN 10485906 10754326 10820262 10952726 11134049 11399519 11830590 11875494 11964313 12193701 12223527 12433365 12796776 12811837 12907458 12967644 14607900 14607933 14660645 14764699 15465827 15644117 15699106 15814715 16127449 16878026 17016554 17260466 17404308 17485448 17513775 17559085 17689680 18272812 18345002 19833085 19879327 21097505 21263073 21930765 23390297 25960930 6357187 7594497 8683106 8871614
STAT1 STAT3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19122651 17558387 22693070
STAT3 IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 22927445 22363173 19797626 22547075 18765795 18616672 23954444 20493732 19751774 22105366 10391682 24315995 20930550
JAK1 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 121.0 1.0 Omnipath 18691551 20169197 19901323 12626585 12759422 15805299 10918587 9305919 15261459 21420464 8272872 10851062 12093291 17878297 12626508 12351624 12040185 16497976 15592455 20966397 8662928 18941194 17389395 23331499 11306517 8756628 12576423 11350938 12244150 18669613 7796300 11294897 24710148 11163236 11722592 11418623 8085155 12244095 21690253 14764663 9535918 21098725 9083098 8662591 22905257 14565860 27774606 8626374 19723038 29145629 26260587 9566874 24501689 25297818 9651359 11940572 11429593 11564763 12517932 14551213 8662795 19535621 23124025 18389480 15284024 11706020 11850821 17016520 9582023 17595657
TYK2 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 29145629 21098725 12626585 10542297 23331499 15261459 8662928 30910759 23673666 14565860 12023369 30029643 14764663 18389480 23124025 25516297
IL6 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 43.0 1.0 Omnipath 26291658 30185178 20185553 28222632 11322950 30143645 27074565 28687744 21538419 16278387 28128332 24496235 26166037 21625597 20371721 25750173 29330478 19962667 26010889 24513872 29702530 25881314 24078775 27866206 24619648 27840174 19380824 24661007 11728826 21619877 11056211 17142955 26417930 29270528 18611949 25452693 27795451 16520748 26843613 29807795 21442031 26893580 26061710
MAPK8 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 66.0 1.0 Omnipath 23255093 17502367 21702955 19413330 11335711 9343414 23331499 15465816 12576423 11350938 20068231 12763138 9872331 18491316 18669648 10521505 18691976 20058876 15979846 14551213 10446219
JAK3 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 23331499 10037026 23109003 11406370 12495636 16189514 12207328 10825200 12934099 18988627 30029643
MAPK9 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20871632 18691976
JAK2 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 167.0 1.0 Omnipath 10918587 8272872 16319070 18718905 15592455 34066153 23166634 33986510 17389395 29162862 29449694 33512408 21098725 9083098 17565041 27748760 27344175 34031055 29290793 21285325 33846242 33774038 9566874 25962054 20826784 14551213 26188635 26008966 15284024 26175413 21481791 33774344 26307676 9305919 10925297 15615703 12626508 16497976 32087696 16469875 31914141 23331499 11350938 28978186 16306356 33824475 18988627 17401459 19147545 15151905 12637586 34433042 8626374 15950906 27181202 24793791 20455003 21575192 32094172 15322111 17016520 34247191 19901323 12626585 27086926 21166956 23906537 31976162 9211920 12576423 22306293 10207096 12075083 11294897 26787900 12244095 14701810 33909625 11803465 17360477 28827891 33820781 19159681 18939995 11445068 27941883 11429593 30054295 26675255 11850821 9582023 34067421 34707127 15786731 25986861 27351213 34118143 15077188 26699492 12595539 21071413 18498667 22153071 15156153 33513694 25915428 11940572 12529382 18525315 24501689 33839684 24316223 19834108 9575217
STAT3 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 25609649 8662591 12070153 31462771 25241761 11722592 8710878 9794795 23268184 15284024 16189514 9535918 11594781
STAT3 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19345327 12057007 23335796 16713569 18448488
TRAF2 TNF â—¼   PHYSICAL_INTERACTION 60.0 1.0 ACSN 10820262 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12433365 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18345002 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
RIPK1 TNF â—¼   PHYSICAL_INTERACTION 57.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
TNF TRAF3 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 7639698 25152365 19815541 8702708 7544915
TNF TNFRSF1A â—¼   PHYSICAL_INTERACTION 33.0 1.0 ACSN 11112697 11274345 11279185 12531547 12646658 1330325 1431106 14607933 14625680 15099563 15310755 15699106 17916596 18633355 19411070 20038811 20184663 21133840 21411734 21826665 21920725 22955274 23170255 23430059 23510023 23567181 23769623 24092389 26201938 26801188 28765050 8663014 8910423
TNF TRADD â—¼   PHYSICAL_INTERACTION 65.0 1.0 ACSN 10925299 11003656 11112697 11274345 11279185 11280761 11438547 11460167 11875494 12531547 12646658 12811837 1330325 1431106 14607933 14625680 14660645 14730360 15099563 15310755 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 21920725 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26801188 26972597 28574505 28765050 8663014 8910423 9488730
TNF FADD â—¼   PHYSICAL_INTERACTION 57.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
TNF TNFRSF1A â—¼   PROTEIN_INTERACTION 33.0 1.0 ACSN 11112697 11274345 11279185 12531547 12646658 1330325 1431106 14607933 14625680 15099563 15310755 15699106 17916596 18633355 19411070 20038811 20184663 21133840 21411734 21826665 21920725 22955274 23170255 23430059 23510023 23567181 23769623 24092389 26201938 26801188 28765050 8663014 8910423
RIPK1 TNF â—¼   SHARES_COMPLEX 57.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
TRAF2 TNF â—¼   SHARES_COMPLEX 60.0 1.0 ACSN 10820262 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12433365 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18345002 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
TNF TRADD â—¼   SHARES_COMPLEX 65.0 1.0 ACSN 10925299 11003656 11112697 11274345 11279185 11280761 11438547 11460167 11875494 12531547 12646658 12811837 1330325 1431106 14607933 14625680 14660645 14730360 15099563 15310755 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 21920725 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26801188 26972597 28574505 28765050 8663014 8910423 9488730
TNF FADD â—¼   SHARES_COMPLEX 57.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
TRAF2 TNF â—¼   ENZYMATIC_REACTION ✅ 60.0 1.0 ACSN 10820262 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12433365 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18345002 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
STAT1 TNF â—¼   ENZYMATIC_REACTION ✅ 46.0 1.0 ACSN 10485906 10754326 10820262 10952726 11134049 11399519 11830590 11875494 11964313 12193701 12223527 12433365 12796776 12811837 12907458 12967644 14607900 14607933 14660645 14764699 15465827 15644117 15699106 15814715 16127449 16878026 17016554 17260466 17404308 17485448 17513775 17559085 17689680 18272812 18345002 19833085 19879327 21097505 21263073 21930765 23390297 25960930 6357187 7594497 8683106 8871614
TNF TRADD â—¼   ENZYMATIC_REACTION ✅ 65.0 1.0 ACSN 10925299 11003656 11112697 11274345 11279185 11280761 11438547 11460167 11875494 12531547 12646658 12811837 1330325 1431106 14607933 14625680 14660645 14730360 15099563 15310755 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 21920725 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26801188 26972597 28574505 28765050 8663014 8910423 9488730
TNF MAP3K7 â—¼   ENZYMATIC_REACTION ✅ 57.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
TNF SMPD1 â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 11112697 11274345 11279185 12531547 12646658 1330325 1431106 14607933 14625680 15099563 15310755 15699106 17916596 18633355 19411070 20038811 20184663 21133840 21411734 21826665 21920725 22955274 23170255 23430059 23510023 23567181 23769623 24092389 26201938 26801188 28765050 8663014 8910423
TYK2 TNF â—¼   DOWN_REGULATES ✅ - 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
IL6 TNF â—¼   DOWN_REGULATES ✅ - 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
JAK2 TNF â—¼   DOWN_REGULATES ✅ - 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
JAK1 TNF â—¼   DOWN_REGULATES ✅ - 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
STAT6 TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 17878383 10227996 9092569 16004996 11254707
NFKB1 TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 74.0 1.0 Omnipath 17513725 12058956 24337575 12657243 17704137 12471036 17707233 7624137 11259437 12686724 16433741 26114754 20237317 7876168 16707469 12117498 14976218 10485496 15465827 8622636 15812247 21138578 18990758 10748079 15013838 15749903 16916598 17646159 10754326 16040075 10837498 18285351 11675405 11739517 15743782 20066113 20617556 17085785 8530146 8805669 10919279 14960579 1740105 10963848 16055086 9742085 17292554 10553096 11312646 15543947 17442180 16285952 10079106 11297551 10551799 10201927 12907458 8679226 9281604 22782967 8219230 11749970 9916895 11094063 11490006 7895918 1618817 16483936 18057724 20722069 16569682 9452482 17407192 17082635
RELA TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 136.0 1.0 Omnipath 26596471 17707233 20817730 12686724 27075886 21765477 21537341 19530226 17390058 18077329 15064230 20617556 8805669 17351769 23335080 21573233 17292554 16285952 9916895 11749970 7895918 17496784 12628924 23857586 12657243 15857826 12471036 11259437 16433741 9831247 20237317 15465827 26023919 22661093 10748079 15013838 17350185 10754326 15470505 11827962 20139176 26408955 22901690 18772140 21108432 22742857 23195252 18362169 24012417 11312646 17442180 9281604 10079106 11297551 15081318 22718766 24908318 8219230 26004152 11094063 11490006 9916692 16483936 18057724 16569682 22138107 18467438 20547752 22723832 19846753 17407192 20221401 19854828 20534538 7876168 16707469 12117498 20544543 23178569 15812247 21138578 12610112 25888873 16916598 16040075 28039105 14749357 20066113 19285436 25161822 22388040 14960579 20195282 16199883 15543947 23971673 10551799 11290773 22798670 22021035 20722069 20221720 27338466 19385047 12058956 26997758 25690886 7624137 20686703 26114754 14976218 10485496 17607667 8622636 11007957 18285351 10837498 11739517 18719026 17268554 17085785 17142966 10963848 9742085 23042817 27534992 10553096 26516703 20696864 10201927 16850160 8679226 21098092 20097764 9129150 17082635
TNF RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 39.0 1.0 Omnipath 15192014 27329558 22240205 15833743 19351843 28187781 15841081 28107185 28373828 26999213 24386331 24957606 26179215 21572963 18258304 28317833 29441018 10722927 19596989 28423685 12881425 25118327 24036851 28089769 21904602 24141032 10938077 30201812 20691659 24166907 19789307 19393267 22768286 26310932 19411070 23789107 28790310 29708974 20507904
TNF TNFRSF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 98.0 1.0 Omnipath 17145710 19084540 8288897 11448951 23746843 22801493 14732063 2848815 9568681 2158863 8182064 9488135 23070005 20080539 11239407 26670046 14743216 21724995 21133840 24070898 25911380 7852363 2170974 17151142 26186194 27560715 25241761 23032187 24726327 20103630 8805640 11502070 19442713 3034874 23955153 18067990 22099304 15485837 22675546 12753742 1310388 12887920 19287455 10634209 2170559 1331108 24980434 22028622
TNF TRADD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 17145710 12887920 19287455 15485837 32196115
TNF NFKBIA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 19053972 24083678 25215581 29088783 24386331 25888769 20460401 16866128 19934328 9363938 24349153
TRADD TNFRSF1A â—¼   PHYSICAL_INTERACTION 60.0 1.0 ACSN 10465784 11112697 11274345 11279185 11668179 12048245 12531547 12556535 12646658 12655147 12738796 1330325 1431106 14607933 14625680 14730360 15099563 15170913 15310755 15592525 15699106 17462996 17496911 17916596 18633355 18641653 18855897 19392652 19411070 19524513 19632174 20038811 20184663 21133840 21232017 21411734 21614932 21826665 21920725 22955274 23010170 23070005 23170255 23430059 23510023 23567181 23769623 23850759 24092389 24378531 26201938 26587781 26653790 26801188 28574505 28765050 8663014 8910423 9379049 9582321
RIPK1 TNFRSF1A â—¼   PHYSICAL_INTERACTION 30.0 1.0 ACSN 10465784 11274345 11668179 12048245 12556535 12655147 12738796 14730360 15170913 15592525 17462996 17496911 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23070005 23850759 24378531 26587781 26653790 28574505 28765050 9379049 9582321
TRAF2 TNFRSF1A â—¼   PHYSICAL_INTERACTION 60.0 1.0 ACSN 10465784 11112697 11274345 11279185 11668179 12048245 12531547 12556535 12646658 12655147 12738796 1330325 1431106 14607933 14625680 14730360 15099563 15170913 15310755 15592525 15699106 17462996 17496911 17916596 18633355 18641653 18855897 19392652 19411070 19524513 19632174 20038811 20184663 21133840 21232017 21411734 21614932 21826665 21920725 22955274 23010170 23070005 23170255 23430059 23510023 23567181 23769623 23850759 24092389 24378531 26201938 26587781 26653790 26801188 28574505 28765050 8663014 8910423 9379049 9582321
TNFRSF1A BIRC3 â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 35941131 22179575 22848449 23313255 24098568 34876703 16282325 20385093 22435550 18178551 19910467
TRAF2 TNFRSF1A â—¼   SHARES_COMPLEX 60.0 1.0 ACSN 10465784 11112697 11274345 11279185 11668179 12048245 12531547 12556535 12646658 12655147 12738796 1330325 1431106 14607933 14625680 14730360 15099563 15170913 15310755 15592525 15699106 17462996 17496911 17916596 18633355 18641653 18855897 19392652 19411070 19524513 19632174 20038811 20184663 21133840 21232017 21411734 21614932 21826665 21920725 22955274 23010170 23070005 23170255 23430059 23510023 23567181 23769623 23850759 24092389 24378531 26201938 26587781 26653790 26801188 28574505 28765050 8663014 8910423 9379049 9582321
RIPK1 TNFRSF1A â—¼   SHARES_COMPLEX 30.0 1.0 ACSN 10465784 11274345 11668179 12048245 12556535 12655147 12738796 14730360 15170913 15592525 17462996 17496911 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23070005 23850759 24378531 26587781 26653790 28574505 28765050 9379049 9582321
TRADD TNFRSF1A â—¼   SHARES_COMPLEX 60.0 1.0 ACSN 10465784 11112697 11274345 11279185 11668179 12048245 12531547 12556535 12646658 12655147 12738796 1330325 1431106 14607933 14625680 14730360 15099563 15170913 15310755 15592525 15699106 17462996 17496911 17916596 18633355 18641653 18855897 19392652 19411070 19524513 19632174 20038811 20184663 21133840 21232017 21411734 21614932 21826665 21920725 22955274 23010170 23070005 23170255 23430059 23510023 23567181 23769623 23850759 24092389 24378531 26201938 26587781 26653790 26801188 28574505 28765050 8663014 8910423 9379049 9582321
TRADD TNFRSF1A â—¼   ENZYMATIC_REACTION ✅ 60.0 1.0 ACSN 10465784 11112697 11274345 11279185 11668179 12048245 12531547 12556535 12646658 12655147 12738796 1330325 1431106 14607933 14625680 14730360 15099563 15170913 15310755 15592525 15699106 17462996 17496911 17916596 18633355 18641653 18855897 19392652 19411070 19524513 19632174 20038811 20184663 21133840 21232017 21411734 21614932 21826665 21920725 22955274 23010170 23070005 23170255 23430059 23510023 23567181 23769623 23850759 24092389 24378531 26201938 26587781 26653790 26801188 28574505 28765050 8663014 8910423 9379049 9582321
TRAF2 TNFRSF1A â—¼   ENZYMATIC_REACTION ✅ 60.0 1.0 ACSN 10465784 11112697 11274345 11279185 11668179 12048245 12531547 12556535 12646658 12655147 12738796 1330325 1431106 14607933 14625680 14730360 15099563 15170913 15310755 15592525 15699106 17462996 17496911 17916596 18633355 18641653 18855897 19392652 19411070 19524513 19632174 20038811 20184663 21133840 21232017 21411734 21614932 21826665 21920725 22955274 23010170 23070005 23170255 23430059 23510023 23567181 23769623 23850759 24092389 24378531 26201938 26587781 26653790 26801188 28574505 28765050 8663014 8910423 9379049 9582321
TNFRSF1A SMPD1 â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 11112697 11274345 11279185 12531547 12646658 1330325 1431106 14607933 14625680 15099563 15310755 15699106 17916596 18633355 19411070 20038811 20184663 21133840 21411734 21826665 21920725 22955274 23170255 23430059 23510023 23567181 23769623 24092389 26201938 26801188 28765050 8663014 8910423
CASP7 TNFRSF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11755217 16189514
TNFRSF1A TRADD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 72.0 1.0 Omnipath 17145710 8565075 8943045 11934887 8612133 9915703 11684708 8621670 9430227 19641494 27552911 16611992 21760970 11821416 10187805 21724995 12721308 21741934 21232017 10795740 21119000 15310755 11502070 15115707 23955153 18776134 18939944 9916731 9129204 9082980 15485837 15173123 22297296 15357952 24130170 12887920 10634209 24758719 19524513 15465831 7758105 11035039 8791485 15725726
TNFRSF1A FADD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21760970 15357952 15033800 21741934 9129204
TNFRSF1A CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15357952 12887920 21741934 8875942 15725726
TNFRSF1A RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 62.0 1.0 Omnipath 25681446 11002422 20547836 8612133 18450452 27552911 26802121 10356400 19773432 18621737 23815148 16611992 22179575 12721308 21741934 7538908 18949366 21113135 8985253 10744744 10795740 21119000 22733818 10755617 27321185 15115707 24098568 18939944 18329793 20825417 20448643 15357952 21737329 12887920 24130170 15258597 24758719 16115877 19524513 18724939 16968706 22817896 28817177 18022363 19815541 25388546 21331078 22848449
TNFRSF1A TRAF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 34.0 1.0 Omnipath 26212014 8565075 8943045 8612133 16713569 16611992 22179575 11821416 7544915 12721308 21741934 10795740 21119000 19150425 27321185 25241761 15115707 18776134 15743837 15485837 20448643 12887920 24735611 20333651 18022363 19815541
TNFRSF1A CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23815148 21724995 10795740 24323043 10755617
NFKB1 XIAP â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 17435549 21725609 23178297 23572150
NFKB1 XIAP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15041463 18223231 14739605 16157589 18978816 18761050 15756023 18566231 16453001
RELA XIAP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15041463 18223231 14739605 16157589 18978816 18761050 15756023 18566231 16453001
XIAP CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 45.0 1.0 Omnipath 11447297 11257231 18521960 31467278 15200957 9384571 9545235 14512414 23979166 16189514 11359776 9230442 10508158 19559631 11257230 9525868 11583623 15580265 11257232 23074197 19698783
MAPK8 H2AX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 22972376 16818236 19234442 17211821
MAPK9 H2AX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16818236 19234442 18158901
TRAF3 IRF3 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15210742 16281057 14703513 9566918 17157040
TLR4 IRF3 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 14517278 15210742 14703513 9566918 17823124 17157040
TLR3 IRF3 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15210742 16281057 14703513 9566918 17157040
IRF3 TICAM2 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 14517278 15210742 14703513 9566918 17823124 17157040
IRF3 STING1 â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 12133833 15210742 22394562 16281057 18818105 16306936 19926846 19776740 22579474 19433799 24560620
IRF3 IFNA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10938111 11473119 12821121 19349300 24185615 10692430
IRF3 IFNA4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 11846978 11884139 12242290 9786932 9707562 12821121 16380379 17785777 9446577 10692430
IRF3 IFNA5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20638368 19349300 18851954 12242290
IRF3 CXCL10 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 16253303 19541850 23405030 20483755 18691624 16490936 12821121 24257594
IRF3 IFNA13 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 15741273 15331713 10048763 10933732 11473119 8524823 9891032 17785777 19193793 9877175 22593165 10938111 11303025 12242290 21795596 24278020 23028052 19349300 10692430 27012395 11162841 24535579 12821121 16641293 20047764
IRF3 IFNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 84.0 1.0 Omnipath 19108859 22911767 20453844 22684309 15857993 17540767 16699525 9891032 24185615 12885884 16125763 19349300 20581830 11846976 20610716 16954376 23911869 9707562 12821121 18851954 26483348 23096996 12604599 12829834 22065573 19176627 9649509 20375222 24180280 27481269 18539711 21492741 19570869 20048166 16641293 20304918 15955070 25531393 18641315 19153231 24257594 20130065 16186222 15699120 12077266 17785777 17243100 22285490 9877175 11303025 22417706 23843640 21148557 18225953 17692882 21281747 11222729 9541017 20660350 21228327 17652396 18614628 19541850 20083668 24532789 22902624 18272195 17079289 21632562 17079305 17496231 22083261 10938111 19846511 10848607 17845078 9446577 10692430 18309294 20483755 17947522 24656046 17296604
IKBKB IRF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 25070846 20604809 9566918 14703513 19153595 27992402 18272581 16914100
MAVS IRF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17020950 25636800 21903422 16153868 22750291
MAPK8 IRF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19153595
TICAM1 IRF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14739303 12471095 16281057
TBK1 IRF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 90.0 1.0 Omnipath 24549848 18583960 22072751 16380379 26811330 16127453 17618271 23478265 19153231 12692549 28618271 17599067 22388039 15841462 25636800 21903422 15210742 33990776 20532218 16699525 20170763 30842273 12702806 16306043 17018283 20628368 16914100 33411856 23746807 28159912 16394098 18356163 22904301 34379517 22810896 14703513 22750291 27548204 29800227 22079989 24056301 14679297 17706453 20511230 24396068 19211767 18440553 16281057 12524442 16625202 9463386 19893624 18636086 15749911 18818105 27125670 24807708 15695821 9566918 30496178 17526488 19656901 23028469 32351706 24371060 15367631 16199137 25803835 24622840 16155125
IFNA6 IFNAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21856167
IFNA6 IFNAR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21856167
VPS4A CHMP2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 14505570 30989108 16730941
FTH1 FTL â—¼   PHYSICAL_INTERACTION 4.0 1.0 ACSN 17603935 26653790 26794443 27048822
FTH1 FTL â—¼   SHARES_COMPLEX 4.0 1.0 ACSN 17603935 26653790 26794443 27048822
RELA CCL4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22030901 27737814 11342414
IFNA14 IFNAR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21856167
IFNA14 IFNAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21856167
TLR4 FADD â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 21737330 15814722 19278658 12620240 20308068 12181749
TLR3 FADD â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 22421964 21737330 15814722 19278658 12620240 20308068 12181749
CASP8 FADD â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
RIPK1 FADD â—¼   PHYSICAL_INTERACTION 90.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 1134007 11438547 11460167 11583996 11875494 12215447 12646658 12702723 12724420 12811837 1431106 14607933 14625680 14660645 14730360 14744430 15099563 15592525 15699106 15760909 16406523 16498403 16713974 16940415 17301840 17462996 17916596 18264787 18545270 18633355 18641653 19392652 19411070 19427028 19498109 19524512 19524513 19597341 19632174 19838173 20038811 20184663 20435894 20452955 20531300 21133840 21232017 21411734 21826665 22421439 22427918 22955274 23010170 23069999 23073834 23170255 23377657 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24366341 24378531 24699077 24958845 26024392 26201938 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 8910423 9184224 9217161 9488730 9759866
TRAF2 FADD â—¼   PHYSICAL_INTERACTION 74.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 1134007 11438547 11460167 11583996 11875494 12215447 12646658 12702723 12724420 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 15760909 16406523 16498403 16713974 16940415 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19597341 19632174 19838173 20038811 20184663 20435894 20452955 20531300 21133840 21232017 21411734 21826665 22427918 22955274 23010170 23069999 23170255 23377657 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 27984721 28574505 8910423 9488730 9759866
FADD CFLAR â—¼   PHYSICAL_INTERACTION 48.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16406523 16498403 16940415 17462996 18641653 19392652 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866
FADD TICAM2 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 21737330 15814722 19278658 12620240 20308068 12181749
FADD FASLG â—¼   PHYSICAL_INTERACTION 52.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9184224 9217161 9488730 9759866
FADD CASP8 â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 11003656 15325588 17462996 20531300 23725295 24070470 26587781 26972597 28574505 9488730
FADD MLKL â—¼   PHYSICAL_INTERACTION 43.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866
FADD TRADD â—¼   PHYSICAL_INTERACTION 57.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
FADD RIPK3 â—¼   PHYSICAL_INTERACTION 43.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866
FADD TICAM1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 22421964 21737330 15814722 19278658 12620240 20308068 12181749
FADD FAS â—¼   PHYSICAL_INTERACTION 52.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9184224 9217161 9488730 9759866
RIPK1 FADD â—¼   SHARES_COMPLEX 90.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 1134007 11438547 11460167 11583996 11875494 12215447 12646658 12702723 12724420 12811837 1431106 14607933 14625680 14660645 14730360 14744430 15099563 15592525 15699106 15760909 16406523 16498403 16713974 16940415 17301840 17462996 17916596 18264787 18545270 18633355 18641653 19392652 19411070 19427028 19498109 19524512 19524513 19597341 19632174 19838173 20038811 20184663 20435894 20452955 20531300 21133840 21232017 21411734 21826665 22421439 22427918 22955274 23010170 23069999 23073834 23170255 23377657 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24366341 24378531 24699077 24958845 26024392 26201938 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 8910423 9184224 9217161 9488730 9759866
TRAF2 FADD â—¼   SHARES_COMPLEX 74.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 1134007 11438547 11460167 11583996 11875494 12215447 12646658 12702723 12724420 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 15760909 16406523 16498403 16713974 16940415 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19597341 19632174 19838173 20038811 20184663 20435894 20452955 20531300 21133840 21232017 21411734 21826665 22427918 22955274 23010170 23069999 23170255 23377657 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 27984721 28574505 8910423 9488730 9759866
FADD RIPK3 â—¼   SHARES_COMPLEX 43.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866
FADD MLKL â—¼   SHARES_COMPLEX 43.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866
FADD CASP8 â—¼   SHARES_COMPLEX 10.0 1.0 ACSN 11003656 15325588 17462996 20531300 23725295 24070470 26587781 26972597 28574505 9488730
FADD TRADD â—¼   SHARES_COMPLEX 57.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
FADD FAS â—¼   SHARES_COMPLEX 52.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9184224 9217161 9488730 9759866
FADD CFLAR â—¼   SHARES_COMPLEX 48.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16406523 16498403 16940415 17462996 18641653 19392652 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866
FADD FASLG â—¼   SHARES_COMPLEX 52.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9184224 9217161 9488730 9759866
TRAF2 FADD â—¼   ENZYMATIC_REACTION ✅ 74.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 1134007 11438547 11460167 11583996 11875494 12215447 12646658 12702723 12724420 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 15760909 16406523 16498403 16713974 16940415 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19597341 19632174 19838173 20038811 20184663 20435894 20452955 20531300 21133840 21232017 21411734 21826665 22427918 22955274 23010170 23069999 23170255 23377657 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 27984721 28574505 8910423 9488730 9759866
FADD CFLAR â—¼   ENZYMATIC_REACTION ✅ 48.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16406523 16498403 16940415 17462996 18641653 19392652 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866
FADD MAP3K7 â—¼   ENZYMATIC_REACTION ✅ 57.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
FADD MLKL â—¼   ENZYMATIC_REACTION ✅ 43.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866
FADD RIPK3 â—¼   ENZYMATIC_REACTION ✅ 43.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866
TNFRSF10B FADD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 11376335 15173180 9430228 12721308 10894160 14585074 16189514 9430227 15452120
STAT1 FADD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10848577
TNFRSF10A FADD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 11376335 9430228 10894161 10894160 14585074 16189514 9430227 15452120
TRADD FADD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 8565075 14744432 12911633 21760970 9430228 21724995 21741934 12796506 10911999 20203691 23955153 32296183 12107169 11112409 11464215 8681376 12887920 24686082 21183682 18545270
CFLAR FADD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 27321185 12887920 9217161 9326610 21737330 26972597 9228018 17047155 14637155 16189514 20829884 9208847 12220669
FAS FADD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 62.0 1.0 Omnipath 22864571 8521815 11717445 21713032 16762833 23606538 8967952 20935634 7538907 21803845 9325248 19118384 12721308 21959933 18328427 16189514 25563855 10196099 17159907 27321185 26186194 25241761 9880544 16498403 21625644 9082980 12107169 15659383 15993755 21382479 7536190 11464215 26942442 11035039 15725726 16410793
FADD CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 82.0 1.0 Omnipath 22864571 17145710 11717445 19524512 34591612 15280356 17047155 27552911 12911633 25043603 21458669 11788820 19176810 21525013 21988832 22179575 25939870 12702723 21737330 21741934 26437781 25911380 9228018 21785459 20829884 23972990 21620750 12220669 9774341 17159907 10521396 27321185 17290218 27560715 20103630 24098568 20203691 14612908 8681377 18485876 12107169 15659383 22421964 20448643 9343261 20125124 8681376 12887920 19060883 21737329 23142077 22173242 26972597 22274400 19935698 16410793
FADD RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 38.0 1.0 Omnipath 16585540 22864571 26733177 11002422 11854271 19524512 21458669 21525013 21052097 26865630 21741934 23972990 21620750 26186194 27560715 24098568 20203691 16227629 32296183 18485876 32024820 22890322 11464215 21737329 12887920 21183682 19524513 26972597 19373245 22848449 24577083
NFKB1 NFKBIA â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 1829648 21725609 23178297 23572150 8096091
IKBKB NFKBIA â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 9315679 9914500 9721103 10593898 9135156
RELA NFKBIA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 18204072 17876798 24083678 15499023 25759022 23422506 12859951 7775482 11744993 22723832 23450368 11060311 12885753 18981184 9250151
NFKB1 NFKBIA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 17876798 15499023 17709515 7775482 11744993 10454561 11060311 12885753 9250151
NFKB1 NFKBIA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 61.0 1.0 Omnipath 17145710 25609649 7862124 1340770 16210649 16970925 21719482 9738011 9865693 10497169 8657102 9572494 9315679 21988832 8887676 10329681 1829648 14743216 17003112 11313474 20558726 26496610 7867065 7891711 10837071 7831327 15836773 26186194 11571291 15214841 17561400 16846590 9566883 8096091 15371334 7479976 11020244 9426183 16493424 15145317 8631829 20237821 20980497 16513645 9597130 7479848 7739549 7628694 10655476
TBK1 NFKBIA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 25.0 1.0 Omnipath 10783893 9721103 16007147 12138192 7796813 12403772 10990461 10421793 11815618 8657102 10398585 8601309
RELA NFKBIA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 134.0 1.0 Omnipath 17145710 15657065 11801607 25609694 15226358 17003112 9057089 26496610 19219072 23850221 7831327 12927781 16683270 17301240 17561400 9566883 10391945 8887633 16209943 21719482 10066434 8657102 10581242 29734393 21988832 12419806 14743216 16105840 15671248 9751059 9990853 25759022 10498867 8246997 7878004 11020244 9426183 15845455 26476452 23563313 16951195 25520503 9694722 11287411 10329681 15799966 17612295 24457201 10085161 10837071 10969074 11571291 9573251 15214841 16846590 20065107 7479976 24248593 8887627 15145317 16493424 9135156 24634218 7479848 15024091 14636585 26463447 7862124 1340770 22081069 8139561 27923823 16970925 9738011 9865693 9572494 11231305 14685242 20797629 11313474 16226509 14690596 22022389 21217772 26186194 30213788 15371334 8978697 20980497 7739549 7628694
EIF2AK2 NFKBIA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 24.0 1.0 Omnipath 9721103 16007147 12138192 10723127 7796813 12403772 8657102 10398585 8601309 9214631
CHUK NFKBIA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 113.0 1.0 Omnipath 17145710 15922746 11087742 18074035 12626540 11527961 9244310 11809792 15836773 16177806 9721103 18501560 11923072 17706453 9509763 10723801 11858955 10421793 25133483 10398585 9346484 9346241 21765415 8657102 16737960 9315679 9252186 21490922 16219905 14743216 20484017 10329646 18922877 10882136 16153868 10195894 14751757 16007147 7796813 17053167 9632633 15856023 17965022 10783893 10602462 23602409 27682876 10469655 16965765 15084594 16493072 11095741 12138192 10723127 15210742 10329681 7878466 26930276 9914500 9520446 12514169 12403772 10527519 15145317 16493424 9135156 16023083 12637324 10593898 14636585 9214631 7862124 10074115 15389589 12486103 9891086 8601309 10880512 7739562 16286467 17379600 23109003 9689078 15371334 10733566 29145629 11042193 23970940 10085062 17468758
IKBKB NFKBIA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 164.0 1.0 Omnipath 18593939 17145710 18375836 11087742 16793322 11527961 28086098 21232017 12429743 21423167 17693123 21399639 15836773 16177806 9721103 29139553 9271416 17561400 11923072 10889159 17706453 10723801 12791687 11858955 22037600 16365431 10421793 25133483 10398585 9346484 9346241 11158290 18539148 23328071 15574499 21765415 16818647 8657102 18202307 16737960 9315679 21490922 9252186 20001801 15919917 16495515 11368781 16291755 24386391 14743216 25759022 10329646 10882136 16153868 10195894 14751757 18981174 10807933 16007147 7796813 9632633 15856023 17965022 25753787 10783893 10602462 27682876 16965765 15084594 19196987 17322026 12138192 10723127 15210742 16319058 15217903 15218526 7878466 9914500 17367806 9520446 15214841 16846590 12514169 18657515 12403772 10527519 15145317 16888014 16493424 17047224 9135156 15024091 16023083 10593898 14636585 22579987 9214631 24911653 7862124 10320352 16970925 23707515 9346485 12949498 17363905 12486103 9891086 8601309 10880512 7739562 16286467 23109003 9689078 25595906 15371334 16285893 11356195 29145629 23970940 10085062 11815618 17468758 17615396 24586253 17072322
STAT1 STAT5B â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 23073628 15790786 11369651 15007386 12481435 15526160 28403213 10358045 28192400 17546049 9355737
STAT1 STAT2 â—¼   PHYSICAL_INTERACTION 20.0 1.0 ACSN 11134049 11830590 12193701 12223527 12796776 12811837 12967644 14607900 14764699 15814715 17016554 17513775 17559085 17689680 18272812 19833085 21263073 21930765 25960930 8683106
STAT1 JAK3 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 11418623 12517932 12244150 27774606 12093291 12759422
STAT1 STAT5A â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 23073628 15790786 11369651 15007386 12481435 15526160 28403213 10358045 28192400 17546049 9355737
STAT1 STAT2 â—¼   SHARES_COMPLEX 20.0 1.0 ACSN 11134049 11830590 12193701 12223527 12796776 12811837 12967644 14607900 14764699 15814715 17016554 17513775 17559085 17689680 18272812 19833085 21263073 21930765 25960930 8683106
JAK1 STAT1 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 10426994 11907067 12244150 12811837 15536084 16081783 16713974 16785506 19833085 20856220 21840487 23124025 24751819 7512720 7521688
JAK2 STAT1 â—¼   ENZYMATIC_REACTION ✅ 17.0 1.0 ACSN 11015446 11306493 11777960 11867689 12393492 12811837 14610620 19833085 20406969 20805416 21765015 22323450 22869907 23046136 24030977 24091328 27216177
IFNAR2 STAT1 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 11207245 11698286 11964292 12811837 14610620 14764699 15864272 17513775 19833085 21115385 21840487 21930765 21930769 7512720 7521688 7543512
IFNGR1 STAT1 â—¼   ENZYMATIC_REACTION ✅ 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
IFNAR1 STAT1 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 11207245 11698286 11964292 12811837 14610620 14764699 15864272 17513775 19833085 21115385 21840487 21930765 21930769 7512720 7521688 7543512
IFNGR2 STAT1 â—¼   ENZYMATIC_REACTION ✅ 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
TYK2 STAT1 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 11207245 11698286 11964292 12811837 14610620 14764699 15864272 17513775 19833085 21115385 21840487 21930765 21930769 7512720 7521688 7543512
IFNG STAT1 â—¼   ENZYMATIC_REACTION ✅ 69.0 1.0 ACSN 10485906 10754326 10820262 10952726 11134049 11399519 11489965 11579131 11777960 11830590 11870632 11875494 11964313 12193701 12223527 12413632 12433365 12796776 12811837 12818165 12907458 12967644 14607900 14607933 14660645 14764699 15465827 15634932 15644117 15699106 15778339 15811952 15814715 16127449 16286920 16424049 16713974 16878026 17016554 17260466 17404308 17485448 17513775 17559085 17689680 1825141 18272812 18345002 19833085 19879327 20038811 20819927 21097505 21149606 21263073 21411734 21930765 23390297 24658051 25960930 26755705 2965306 6357187 6425450 7594497 8683106 8871614 9834059 9864217
STAT1 RIPK1 â—¼   ENZYMATIC_REACTION ✅ 46.0 1.0 ACSN 10485906 10754326 10820262 10952726 11134049 11399519 11830590 11875494 11964313 12193701 12223527 12433365 12796776 12811837 12907458 12967644 14607900 14607933 14660645 14764699 15465827 15644117 15699106 15814715 16127449 16878026 17016554 17260466 17404308 17485448 17513775 17559085 17689680 18272812 18345002 19833085 19879327 21097505 21263073 21930765 23390297 25960930 6357187 7594497 8683106 8871614
IFNG STAT1 â—¼   DOWN_REGULATES ✅ - 69.0 1.0 ACSN 10485906 10754326 10820262 10952726 11134049 11399519 11489965 11579131 11777960 11830590 11870632 11875494 11964313 12193701 12223527 12413632 12433365 12796776 12811837 12818165 12907458 12967644 14607900 14607933 14660645 14764699 15465827 15634932 15644117 15699106 15778339 15811952 15814715 16127449 16286920 16424049 16713974 16878026 17016554 17260466 17404308 17485448 17513775 17559085 17689680 1825141 18272812 18345002 19833085 19879327 20038811 20819927 21097505 21149606 21263073 21411734 21930765 23390297 24658051 25960930 26755705 2965306 6357187 6425450 7594497 8683106 8871614 9834059 9864217
STAT1 FAS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11309387 19262492 16317104 14602726 22805310
STAT1 IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 70.0 1.0 Omnipath 12759422 14735146 26170288 8823363 1833631 8647290 7619083 11416037 12130529 16162660 21178011 9218597 12493643 17283162 15217838 10830295 24200694 7957928 19476491 9271410 19262492 7565811 9880553 17878383 9748323 21039465 17016440 10881178 21530491 17270146 12052885 15055356 10201928 18616672 13678429 19124156 9491997 24478085 8509377 8990168 12893768 16380218 23740952 17105733 16195385 23419754 19935876 7796811 17558024 19929594 10713330 23645984 9548487 11390994 12223098 15931263 17689680 18802113 18787082 10440232 20004484 10373559 10585866 10707961 12403783 23582260 10982806 9059994 16785492 22767256
STAT1 IFNA13 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 11244574 9325014 11909852 15714000 1833631 14978477 12356687 8454630 17617740 20585034 22589541 8683106 1756724 22252317 11566724 11591697 11972347 18616672 19135978 8509377 10586107 20526365 15664995 8444884 17050680 18562017 7796811 18778729 1315834 17374731 22479354 10406469 21659501 8805641 18024894 19561067 8034722 15467722 23598529 17689680 12748307
STAT1 IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 8683127 24242046 23675777 19703987 7619083 18616672 24012417 20693420
STAT1 CXCL10 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 15006601 25199798 22022583 23153456 23740952 9690917 9858321 24127910 12754213 19479051 20585034 20833730 17558387 19136629 28262979
STAT1 AIM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22951020
STAT1 IFNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 9325014 18035482 19096445 17374731 22479354 24478085 15194680 16020513 10321980
MAPK8 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 24913968 14963018
JAK3 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 23109003 11406370 12495636 17277783 9535918
TYK2 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 68.0 1.0 Omnipath 11839738 10918587 15261459 8232552 7543024 15322115 23331499 8780896 10435617 24243840 11294897 7690989 14764663 18988627 12637327 11438544 10748192 14565860 7657660 12817007 23257612 29145629 9355737 11152457 23124025 18389480 10982844 7592750
JAK2 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 81.0 1.0 Omnipath 11839738 10918587 7888666 20353823 7543024 15322115 25950470 23331499 21071413 14978237 11294897 7690989 7504785 18988627 12637327 25535282 11438544 21576360 10748192 7657660 12817007 14984365 7504784 21207025 9355737 11152457 7615558 19834108 15284024 10982844 7592750 19787091
JAK1 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 132.0 1.0 Omnipath 35317858 11839738 10918587 15261459 34950606 11306517 8756628 12244150 8156998 9535918 10748192 7657660 12817007 23257612 27774606 25297818 22306691 8631301 7510216 14963018 15284024 24243840 7592750 10851062 11823427 23331499 7532278 11418623 11722592 18988627 12637327 27387064 8662591 10022928 19088846 32953130 7796299 7504784 23124025 19787091 24058793 20169197 7543024 15322115 18941194 19534553 15978943 14978237 11294897 14764663 21429244 14565860 34228987 25386349 18989459 34521819 9020188 19535621 10982844 21576360 12759422 18508557 8232552 12093291 12040185 20006573 8662795 7690989 20087684 11438544 20035788 11972023 29145629 9355737 11152457 12517932 18389480
IFNGR1 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 10848598 23285134 28143527 24608040 24366643 7514165 27378243 8156998 8605876 8662591 15780933 8910398 28445952 24443556 24777831 26113305 22162832 15494521 7615558
IFNG STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 29796172 23285134 18566411 28430601 28143527 24366643 24608040 17947699 25950470 19846878 27378243 18950705 27570112 15051500 17986321 26467650 23657944 20087684 9649436 22823229 14517275 22178447 22425562 23352233 23562842 28445952 11960596 17997851 24443556 26934444 24777831 11972023 12725866 26113305 22162832 29925830 10707961 23840250 25753288 9454765
STAT2 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 10490982 8621447 24065129 17923090 15978943 1502203 10446176 9724754 14722125 21178011 15825084 21268015 12048190 8605877
EIF2AK2 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23597922 9135145 11278865 16516295 10637230
IFNB1 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23933255 22816309 22194884 17488182 12068083 25885435 26353965 25892232 19174562
CAMK2G STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 45.0 1.0 Omnipath 11972023 20058876 95354205 11839738 9355737 18691976 7543024 20068231 18452278 7690989 14963018 12637327 18669648 15322115
STAT1 IRF9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 29145629 7537377 9242679 23331499 8621447 24065129 17923090 8943351 12590259 17351669
STAT1 CASP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17339457 17085014
TLR4 MAP3K7 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 15327770 19675569 16115877 10882101
TLR3 MAP3K7 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17496917 15327770 19675569 12609980
MAP3K7 TICAM1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 15327770 19675569 16115877 10882101
MAP3K7 TICAM2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 15327770 19675569 16115877 10882101
MAP3K7 CAMK2A â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 12556497 10380924 10391246 10488343 12482967
CHUK MAP3K7 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 20300203 9744859 17047224 11460167 17496917 14514672
TRADD MAP3K7 â—¼   ENZYMATIC_REACTION ✅ 57.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
RIPK1 MAP3K7 â—¼   ENZYMATIC_REACTION ✅ 57.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
TRAF2 MAP3K7 â—¼   ENZYMATIC_REACTION ✅ 57.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
IKBKB MAP3K7 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 20300203 9744859 17047224 11460167 17496917 14514672
TRAF2 MAP3K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 17145710 12547194 20038579 14633987 14743216 17384642
MAP3K7 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 17145710 14960582 16893890 15836773 33895773 12547194 25241761 24911653 2547194 9742107 18949366 11274345 20200282 20194509 10094049 18855897 10187861
MAP3K7 IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 57.0 1.0 Omnipath 24911653 11129660 25195736 16006187 16260493 15502405 14530355 10779355 28159912 10094049 10837071 15836773 25659581 10195894 9689078 17363973 10807933 15214841 16186825 16493424 10022904 18316610 10187861 12547194 33895773 28475177 16301747 15691841 15620648 15327770 29748387 19632174 11460167 17965022
MAP3K7 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15692051 17947236 11865055 17965022 17186025
TLR3 RIPK1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 21931591 15064760 15814722 16115877 16603398
TLR4 RIPK1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 16603398 15814722 16115877 21931591
TRAF2 RIPK1 â—¼   PHYSICAL_INTERACTION 92.0 1.0 ACSN 10465784 10734135 10925299 11003656 11112697 11274345 11280761 1134007 11438547 11460167 11583996 11668179 11875494 12048245 12215447 12556535 12646658 12655147 12702723 12724420 12738796 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15170913 15310755 15592525 15699106 15760909 16406523 16498403 16713974 16940415 17301840 17462996 17496911 17916596 18264787 18292600 18633355 18641653 18855897 19392652 19411070 19524513 19597341 19632174 19838173 20038811 20184663 20435894 20452955 20531300 21133840 21232017 21411734 21614932 21826665 22427918 22955274 23010170 23069999 23070005 23170255 23377657 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 27984721 28574505 28765050 8910423 8974401 9379049 9488730 9582321 9759866
RIPK1 PYGL â—¼   PHYSICAL_INTERACTION 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
RIPK1 TICAM2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 16603398 15814722 16115877 21931591
RIPK1 GLUD1 â—¼   PHYSICAL_INTERACTION 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
RIPK1 RIPK3 â—¼   PHYSICAL_INTERACTION 60.0 1.0 ACSN 10521396 11003656 11274345 1134007 11583996 12215447 12702723 12724420 12887920 15592525 15760909 16469705 16498403 16940415 17462996 17603935 18570872 18621737 18641653 19037093 19131965 19498109 19524512 19524513 19597341 19632174 19838173 19935698 20125124 20531300 20823910 20861672 21133840 21232017 22265414 22421439 22427918 23010170 23069999 23073834 23377657 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 26972597 27558815 27833036 27959630 27984721 28498367 28574505 28645028 9217161 9488730 9759866
RIPK1 MLKL â—¼   PHYSICAL_INTERACTION 53.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16469705 16498403 16940415 17462996 17603935 18641653 19037093 19498109 19524512 19524513 19597341 19632174 19838173 20531300 20823910 20861672 21133840 21232017 22265414 22421439 22427918 23010170 23069999 23073834 23377657 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 26972597 27558815 27833036 27959630 27984721 28498367 28574505 28645028 9217161 9488730 9759866
RIPK1 FAS â—¼   PHYSICAL_INTERACTION 52.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9184224 9217161 9488730 9759866
RIPK1 TRADD â—¼   PHYSICAL_INTERACTION 78.0 1.0 ACSN 10465784 10734135 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11668179 11875494 12048245 12556535 12646658 12655147 12738796 12811837 12887920 1431106 14607933 14625680 14660645 14730360 15099563 15170913 15310755 15592525 15699106 16713974 17301840 17462996 17496911 17560373 17916596 18264787 18292600 18633355 18641653 18855897 19392652 19411070 19524513 19632174 19641494 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21614932 21826665 22955274 23010170 23070005 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 28765050 8910423 8974401 9379049 9488730 9582321
RIPK1 FASLG â—¼   PHYSICAL_INTERACTION 52.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9184224 9217161 9488730 9759866
RIPK1 GLUL â—¼   PHYSICAL_INTERACTION 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
RIPK1 CFLAR â—¼   PHYSICAL_INTERACTION 48.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16406523 16498403 16940415 17462996 18641653 19392652 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866
RIPK1 PGAM5 â—¼   PHYSICAL_INTERACTION 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
TRAF2 RIPK1 â—¼   SHARES_COMPLEX 92.0 1.0 ACSN 10465784 10734135 10925299 11003656 11112697 11274345 11280761 1134007 11438547 11460167 11583996 11668179 11875494 12048245 12215447 12556535 12646658 12655147 12702723 12724420 12738796 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15170913 15310755 15592525 15699106 15760909 16406523 16498403 16713974 16940415 17301840 17462996 17496911 17916596 18264787 18292600 18633355 18641653 18855897 19392652 19411070 19524513 19597341 19632174 19838173 20038811 20184663 20435894 20452955 20531300 21133840 21232017 21411734 21614932 21826665 22427918 22955274 23010170 23069999 23070005 23170255 23377657 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 27984721 28574505 28765050 8910423 8974401 9379049 9488730 9582321 9759866
RIPK1 MLKL â—¼   SHARES_COMPLEX 53.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16469705 16498403 16940415 17462996 17603935 18641653 19037093 19498109 19524512 19524513 19597341 19632174 19838173 20531300 20823910 20861672 21133840 21232017 22265414 22421439 22427918 23010170 23069999 23073834 23377657 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 26972597 27558815 27833036 27959630 27984721 28498367 28574505 28645028 9217161 9488730 9759866
RIPK1 TRADD â—¼   SHARES_COMPLEX 78.0 1.0 ACSN 10465784 10734135 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11668179 11875494 12048245 12556535 12646658 12655147 12738796 12811837 12887920 1431106 14607933 14625680 14660645 14730360 15099563 15170913 15310755 15592525 15699106 16713974 17301840 17462996 17496911 17560373 17916596 18264787 18292600 18633355 18641653 18855897 19392652 19411070 19524513 19632174 19641494 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21614932 21826665 22955274 23010170 23070005 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 28765050 8910423 8974401 9379049 9488730 9582321
RIPK1 PYGL â—¼   SHARES_COMPLEX 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
RIPK1 GLUL â—¼   SHARES_COMPLEX 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
RIPK1 FASLG â—¼   SHARES_COMPLEX 52.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9184224 9217161 9488730 9759866
RIPK1 PGAM5 â—¼   SHARES_COMPLEX 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
RIPK1 CFLAR â—¼   SHARES_COMPLEX 48.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16406523 16498403 16940415 17462996 18641653 19392652 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866
RIPK1 GLUD1 â—¼   SHARES_COMPLEX 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
RIPK1 FAS â—¼   SHARES_COMPLEX 52.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9184224 9217161 9488730 9759866
RIPK1 RIPK3 â—¼   SHARES_COMPLEX 60.0 1.0 ACSN 10521396 11003656 11274345 1134007 11583996 12215447 12702723 12724420 12887920 15592525 15760909 16469705 16498403 16940415 17462996 17603935 18570872 18621737 18641653 19037093 19131965 19498109 19524512 19524513 19597341 19632174 19838173 19935698 20125124 20531300 20823910 20861672 21133840 21232017 22265414 22421439 22427918 23010170 23069999 23073834 23377657 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 26972597 27558815 27833036 27959630 27984721 28498367 28574505 28645028 9217161 9488730 9759866
TRAF2 RIPK1 â—¼   ENZYMATIC_REACTION ✅ 92.0 1.0 ACSN 10465784 10734135 10925299 11003656 11112697 11274345 11280761 1134007 11438547 11460167 11583996 11668179 11875494 12048245 12215447 12556535 12646658 12655147 12702723 12724420 12738796 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15170913 15310755 15592525 15699106 15760909 16406523 16498403 16713974 16940415 17301840 17462996 17496911 17916596 18264787 18292600 18633355 18641653 18855897 19392652 19411070 19524513 19597341 19632174 19838173 20038811 20184663 20435894 20452955 20531300 21133840 21232017 21411734 21614932 21826665 22427918 22955274 23010170 23069999 23070005 23170255 23377657 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 27984721 28574505 28765050 8910423 8974401 9379049 9488730 9582321 9759866
RIPK1 TRADD â—¼   ENZYMATIC_REACTION ✅ 78.0 1.0 ACSN 10465784 10734135 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11668179 11875494 12048245 12556535 12646658 12655147 12738796 12811837 12887920 1431106 14607933 14625680 14660645 14730360 15099563 15170913 15310755 15592525 15699106 16713974 17301840 17462996 17496911 17560373 17916596 18264787 18292600 18633355 18641653 18855897 19392652 19411070 19524513 19632174 19641494 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21614932 21826665 22955274 23010170 23070005 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 28765050 8910423 8974401 9379049 9488730 9582321
RIPK1 RIPK3 â—¼   ENZYMATIC_REACTION ✅ 60.0 1.0 ACSN 10521396 11003656 11274345 1134007 11583996 12215447 12702723 12724420 12887920 15592525 15760909 16469705 16498403 16940415 17462996 17603935 18570872 18621737 18641653 19037093 19131965 19498109 19524512 19524513 19597341 19632174 19838173 19935698 20125124 20531300 20823910 20861672 21133840 21232017 22265414 22421439 22427918 23010170 23069999 23073834 23377657 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 26972597 27558815 27833036 27959630 27984721 28498367 28574505 28645028 9217161 9488730 9759866
RIPK1 MLKL â—¼   ENZYMATIC_REACTION ✅ 53.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16469705 16498403 16940415 17462996 17603935 18641653 19037093 19498109 19524512 19524513 19597341 19632174 19838173 20531300 20823910 20861672 21133840 21232017 22265414 22421439 22427918 23010170 23069999 23073834 23377657 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 26972597 27558815 27833036 27959630 27984721 28498367 28574505 28645028 9217161 9488730 9759866
RIPK1 GLUL â—¼   ENZYMATIC_REACTION ✅ 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
RIPK1 CFLAR â—¼   ENZYMATIC_REACTION ✅ 48.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16406523 16498403 16940415 17462996 18641653 19392652 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866
BIRC2 RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 12887920 18570872 20547836 15147886 21931591 16603398 19284370 18621737
TNFAIP3 RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 20448643 17703191 18246070 15258597 19131965
FAS RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17145710 9740801 7538908
TRADD RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 12887920 24735611 20203691 21724995 8612133 21741934 16603398 21119000
BIRC3 RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 18570872 33526051 15147886 21931591 16603398 19284370 18621737
TRAF2 RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 45.0 1.0 Omnipath 8702708 8612133 25416956 16713569 18621737 25882049 16291755 18981220 21741934 21232017 20577214 11181075 10795740 23972990 21119000 15175328 20203691 21810480 21282461 9712898 32296183 23007157 25716317 20448643 12887920 24735611 15258597 24434549 19815541 16603398 11479302 9020361
RIPK3 RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 11734559 21903422 22265414 19524512 19524513 22817896 26559832 10339433 26319693 11585904 22265413
CASP8 RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 39.0 1.0 Omnipath 17145710 11002422 34389694 19524512 8657102 17047155 10469655 21458669 21419663 21525013 12842894 18570872 21741934 10521396 11002417 12884866 20203691 22421964 11042193 20125124 12887920 12215447 19935698
CFLAR RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12887920 11002417 17047155 10837247
TICAM1 RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 20200155 20404851 16410796 14739303 17982077 15814722 18450748 19734906 15064760 16281057
RIPK1 FAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17145710 18545270 9740801 7538908
TRAF2 CFLAR â—¼   PHYSICAL_INTERACTION 36.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16406523 16498403 16940415 17462996 18641653 19392652 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22427918 23010170 23069999 23377657 23850759 24378531 26587781 26653790 26972597 27984721 28574505 9488730 9759866
TRAF2 FASLG â—¼   PHYSICAL_INTERACTION 36.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16406523 16498403 16940415 17462996 18641653 19392652 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22427918 23010170 23069999 23377657 23850759 24378531 26587781 26653790 26972597 27984721 28574505 9488730 9759866
TRAF2 TRADD â—¼   PHYSICAL_INTERACTION 71.0 1.0 ACSN 10465784 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11668179 11875494 12048245 12556535 12646658 12655147 12738796 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15170913 15592525 15699106 16713974 17301840 17462996 17496911 17916596 18264787 18633355 18641653 18855897 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21614932 21826665 22955274 23010170 23070005 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 28765050 8910423 9379049 9488730 9582321
TRAF2 CASP8 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15024054 20696707 19278658 10837247 19416807 21235526
TRAF2 FAS â—¼   PHYSICAL_INTERACTION 36.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16406523 16498403 16940415 17462996 18641653 19392652 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22427918 23010170 23069999 23377657 23850759 24378531 26587781 26653790 26972597 27984721 28574505 9488730 9759866
TRAF2 CFLAR â—¼   SHARES_COMPLEX 36.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16406523 16498403 16940415 17462996 18641653 19392652 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22427918 23010170 23069999 23377657 23850759 24378531 26587781 26653790 26972597 27984721 28574505 9488730 9759866
TRAF2 TRADD â—¼   SHARES_COMPLEX 71.0 1.0 ACSN 10465784 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11668179 11875494 12048245 12556535 12646658 12655147 12738796 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15170913 15592525 15699106 16713974 17301840 17462996 17496911 17916596 18264787 18633355 18641653 18855897 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21614932 21826665 22955274 23010170 23070005 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 28765050 8910423 9379049 9488730 9582321
TRAF2 FAS â—¼   SHARES_COMPLEX 36.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16406523 16498403 16940415 17462996 18641653 19392652 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22427918 23010170 23069999 23377657 23850759 24378531 26587781 26653790 26972597 27984721 28574505 9488730 9759866
TRAF2 FASLG â—¼   SHARES_COMPLEX 36.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16406523 16498403 16940415 17462996 18641653 19392652 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22427918 23010170 23069999 23377657 23850759 24378531 26587781 26653790 26972597 27984721 28574505 9488730 9759866
TRAF2 FASLG â—¼   ENZYMATIC_REACTION ✅ 36.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16406523 16498403 16940415 17462996 18641653 19392652 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22427918 23010170 23069999 23377657 23850759 24378531 26587781 26653790 26972597 27984721 28574505 9488730 9759866
TRAF2 CFLAR â—¼   ENZYMATIC_REACTION ✅ 36.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16406523 16498403 16940415 17462996 18641653 19392652 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22427918 23010170 23069999 23377657 23850759 24378531 26587781 26653790 26972597 27984721 28574505 9488730 9759866
TRAF2 CHUK â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 11274345 12847084 15592525 17462996 18641653 19392652 19509052 21133840 21232017 23430059 23850759 24378531 26587781
TRAF2 FAS â—¼   ENZYMATIC_REACTION ✅ 36.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16406523 16498403 16940415 17462996 18641653 19392652 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22427918 23010170 23069999 23377657 23850759 24378531 26587781 26653790 26972597 27984721 28574505 9488730 9759866
TRAF2 IKBKB â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 11274345 12847084 15592525 17462996 18641653 19392652 19509052 21133840 21232017 23430059 23850759 24378531 26587781
NFKB1 TRAF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15723831 15041463 19392652 18990758
RELA TRAF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15041463 19392652 21573233 15723831 9733516
CYLD TRAF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 12917691 23405219 17851586
TNFAIP3 TRAF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 20448643 25416956 24008839 8692885 31515488 32296183 10544141 16713569 10755617
TRADD TRAF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 52.0 1.0 Omnipath 8702708 8565075 14585074 16713569 27383048 18621737 14743216 12796506 21741934 11181075 21119000 10911999 20203691 10892748 23955153 11112773 18439848 32296183 15485837 12887920 12517920 19815541 11479302 9020361
TRAF2 BIRC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 18997792 8643514 11907583 16713569 18621737 18997794 21988832 18606850 9384571 16891304 10753917 18981220 24464131 20562859 25241761 23543740 20385093 21331077 23007157 16282325 23524849 8548810 19815541
TRAF2 CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17145710 12887920 20203691 16227629 21741934 17047155 22421964 30054040 11340079
TRAF2 BIRC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 54.0 1.0 Omnipath 21653699 25681446 8943045 8643514 11907583 16713569 20184394 18621737 18997794 21988832 25882049 9384571 21903422 16891304 10753917 20447407 18981220 16189514 15861135 11181075 20348096 20562859 25241761 19584093 32296183 21331077 23007157 16282325 19506082 25716317 23524849 24276241 16263936 12887920 8548810 19815541
TRAF2 TICAM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 19795416 14982987 20418377 20047764
TRAF2 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 15725726 12547194 11359906 25241761 20449947 9244310 16713569 23007157 10795740 24323043 19150425
TRAF2 IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 27387502 15725726 12547194 11359906 25241761 20449947 16713569 18362886 23007157 10795740 21119000 19150425
IFNB1 JAK1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 15312780 9121453 10395669 9334213 15778442 12842042 17969444
IFNAR1 JAK1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15312780 8943354 18508557 15449939 17969444 16171819
IFNG JAK1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 16467876 7617032 7673114 12438563 10986460 7615558 1396683 8550631
JAK1 IFNAR1 â—¼   PHYSICAL_INTERACTION 16.0 1.0 ACSN 11207245 11698286 11964292 12811837 14610620 14764699 15864272 17513775 19833085 21115385 21840487 21930765 21930769 7512720 7521688 7543512
JAK1 TYK2 â—¼   PHYSICAL_INTERACTION 85.0 1.0 ACSN 10433356 10485906 10542212 10623821 11160275 11207245 11306493 11371360 11698286 11867689 11870632 11875494 11964292 12223527 12401408 12496409 12754507 12811837 12818165 1439146 14607900 14610620 14657224 14764699 15099563 15282297 15356132 15573129 15579430 15864272 16200688 16243976 16413922 16424049 16713974 17404308 17485448 17513775 18209571 18250477 1825141 18451175 18555777 18555778 19581928 19833085 20138012 20184663 20406969 20510870 20856220 21097505 21115385 21191065 21220452 21469115 21840487 21930765 21930769 22595692 23034983 23124025 23390297 23567181 24011634 24030977 24091328 24346288 24418198 25002027 25582338 26201938 26268945 26755705 27216177 27557510 2965306 7512720 7521688 7543512 7590867 8837607 9535722 9834059 9845545
JAK1 IFNGR2 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
JAK1 JAK2 â—¼   PHYSICAL_INTERACTION 92.0 1.0 ACSN 10485906 11160275 11306493 11371360 11489965 11579131 11777960 11867689 11870632 11964313 12223527 12401408 12413632 12496409 12754507 12811837 12818165 1439146 14607900 14610620 14657224 15099563 15356132 15573129 15634932 15778339 15811952 15814715 16243976 16286920 16413922 16424049 16713974 17016554 17404308 17485448 17559085 17683974 18209571 18250477 1825141 18272812 18451175 18555777 18555778 19581928 19833085 20038811 20138012 20184663 20237318 20406969 20510870 20581311 20819927 20856220 21097505 21115385 21149606 21411734 21469115 21840487 22595692 22754783 23034983 23124025 23390297 23567181 24011634 24030977 24091328 24346288 24418198 24658051 25002027 25582338 26201938 26268945 26755705 27216177 27557510 2965306 6425450 7512720 7521688 7543512 7590867 8837607 9535722 9834059 9845545 9864217
JAK1 IL6 â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
JAK1 IFNAR2 â—¼   PHYSICAL_INTERACTION 16.0 1.0 ACSN 11207245 11698286 11964292 12811837 14610620 14764699 15864272 17513775 19833085 21115385 21840487 21930765 21930769 7512720 7521688 7543512
JAK1 IFNG â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
JAK1 IFNGR1 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
JAK1 JAK2 â—¼   SHARES_COMPLEX 92.0 1.0 ACSN 10485906 11160275 11306493 11371360 11489965 11579131 11777960 11867689 11870632 11964313 12223527 12401408 12413632 12496409 12754507 12811837 12818165 1439146 14607900 14610620 14657224 15099563 15356132 15573129 15634932 15778339 15811952 15814715 16243976 16286920 16413922 16424049 16713974 17016554 17404308 17485448 17559085 17683974 18209571 18250477 1825141 18272812 18451175 18555777 18555778 19581928 19833085 20038811 20138012 20184663 20237318 20406969 20510870 20581311 20819927 20856220 21097505 21115385 21149606 21411734 21469115 21840487 22595692 22754783 23034983 23124025 23390297 23567181 24011634 24030977 24091328 24346288 24418198 24658051 25002027 25582338 26201938 26268945 26755705 27216177 27557510 2965306 6425450 7512720 7521688 7543512 7590867 8837607 9535722 9834059 9845545 9864217
JAK1 IFNG â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
JAK1 IFNAR1 â—¼   SHARES_COMPLEX 16.0 1.0 ACSN 11207245 11698286 11964292 12811837 14610620 14764699 15864272 17513775 19833085 21115385 21840487 21930765 21930769 7512720 7521688 7543512
JAK1 TYK2 â—¼   SHARES_COMPLEX 85.0 1.0 ACSN 10433356 10485906 10542212 10623821 11160275 11207245 11306493 11371360 11698286 11867689 11870632 11875494 11964292 12223527 12401408 12496409 12754507 12811837 12818165 1439146 14607900 14610620 14657224 14764699 15099563 15282297 15356132 15573129 15579430 15864272 16200688 16243976 16413922 16424049 16713974 17404308 17485448 17513775 18209571 18250477 1825141 18451175 18555777 18555778 19581928 19833085 20138012 20184663 20406969 20510870 20856220 21097505 21115385 21191065 21220452 21469115 21840487 21930765 21930769 22595692 23034983 23124025 23390297 23567181 24011634 24030977 24091328 24346288 24418198 25002027 25582338 26201938 26268945 26755705 27216177 27557510 2965306 7512720 7521688 7543512 7590867 8837607 9535722 9834059 9845545
JAK1 IFNAR2 â—¼   SHARES_COMPLEX 16.0 1.0 ACSN 11207245 11698286 11964292 12811837 14610620 14764699 15864272 17513775 19833085 21115385 21840487 21930765 21930769 7512720 7521688 7543512
JAK1 IL6 â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
JAK1 IFNGR1 â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
JAK1 IFNGR2 â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
JAK1 IL6 â—¼   ENZYMATIC_REACTION ✅ 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
JAK1 IL18 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23390297 24030977 24091328 27216177 2965306 7512720 7521688 9834059
JAK1 STAT6 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23390297 24030977 24091328 27216177 2965306 7512720 7521688 9834059
JAK1 STAT4 â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10820393 12811837 14607946 16212621 16815076 17398124 17459805 19833085 19913445 20007590 20856220 21307131 21840487 23124025 24829413 25582338 7512720 7521688 7523571
IFNAR2 JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9334213 23331499 7988557 12133952 23180781 16710296 18988627
IFNAR1 JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 8943354 18508557 8232552 17351669 8524272 7526154 9334213 23331499 10542297 11694501 10982844 15449939 15312780 8702790 8621447 17969444 8605876 10022928 15120645 16171819 29145629 8197134 16987978 24243840
JAK3 JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 11641425 19901323 20135364 17259970 12207328 10825200 11909529 15659558 12559972 9553136
JAK1 TYK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 8702790 19901323 7504784 7589562 15659558 30029643
JAK1 STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9047382 16741510 11722592 10781830
JAK1 STAT6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 9852261 23331499 9045682 22661199 22000020 10856136 23124025
JAK1 STAT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 29145629 23331499 10542297 24243840 8197134 10022928 7532278 18508557 16987978 8232552 9020188 12040185 8605876 18988627 10982844 25386349
JAK1 STAT5B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16741510 10781830 9047382
JAK1 IFNGR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 12133952 8232552 8550631 8156998 7796299 7615558 8649432 19041276
RBCK1 SHARPIN â—¼   PHYSICAL_INTERACTION 9.0 1.0 ACSN 11280761 11460167 14660645 17301840 18264787 21133840 21232017 24699077 24958845
RBCK1 CYLD â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 26997266 27591049 27545878 24098568 27458237 27307491 22435550
RBCK1 SPATA2 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 26997266 27591049 27545878 24098568 27458237 27307491 22435550
RBCK1 RNF31 â—¼   PHYSICAL_INTERACTION 9.0 1.0 ACSN 11280761 11460167 14660645 17301840 18264787 21133840 21232017 24699077 24958845
RBCK1 RNF31 â—¼   SHARES_COMPLEX 9.0 1.0 ACSN 11280761 11460167 14660645 17301840 18264787 21133840 21232017 24699077 24958845
RBCK1 SHARPIN â—¼   SHARES_COMPLEX 9.0 1.0 ACSN 11280761 11460167 14660645 17301840 18264787 21133840 21232017 24699077 24958845
RNF31 SHARPIN â—¼   PHYSICAL_INTERACTION 9.0 1.0 ACSN 11280761 11460167 14660645 17301840 18264787 21133840 21232017 24699077 24958845
RNF31 CYLD â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 26997266 27591049 27545878 24098568 27458237 27307491 22435550
RNF31 SHARPIN â—¼   SHARES_COMPLEX 9.0 1.0 ACSN 11280761 11460167 14660645 17301840 18264787 21133840 21232017 24699077 24958845
IFNG IFNGR1 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
JAK2 IFNGR1 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
IFNGR1 IFNGR2 â—¼   PHYSICAL_INTERACTION 42.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 22003200 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
JAK2 IFNGR1 â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
IFNG IFNGR1 â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
IFNGR1 IFNGR2 â—¼   SHARES_COMPLEX 42.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 22003200 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
IFNG IFNGR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 60.0 1.0 Omnipath 17145710 16110316 12915721 12438563 7514165 15530433 23331499 16237089 23898330 9111318 15143187 16467876 10986460 18988627 1396683 8550631 20304997 11250200 10860730 12165521 29145629 10811850 7617032 18591661 8631301 7615558 7510216 7673114
IFNGR1 JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 11438544 15864272 17063185 23898330 12040185 7499845
JAK2 IFNG â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
IFNG IFNGR2 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
JAK2 IFNG â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
IFNG IFNGR2 â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
TICAM1 IFNG â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11672593 11964313 12032143 12811837 15644117 16306937 16917499 17114424 20154735 20547845 23508573
STAT4 IFNG â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 10807786 10961885 11449378 12372421 8683106 8700208 9715265
IFNG RELA â—¼   ENZYMATIC_REACTION ✅ 48.0 1.0 ACSN 10485906 10679398 11489965 11579131 11777960 11870632 11964313 12133954 12413632 12759422 12818165 14607900 14668329 15079071 15536066 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17145890 17404308 17550372 17559085 1825141 18272812 19171876 19833085 20038811 20138012 20819927 21149606 21224476 21411734 23430059 24658051 26755705 2965306 6425450 8383323 8580069 8641346 9743347 9834059 9864217
IFNG TLR4 â—¼   ENZYMATIC_REACTION ✅ 41.0 1.0 ACSN 10485906 11489965 11579131 11672593 11777960 11870632 11964313 12032143 12413632 12811837 12818165 14607900 15634932 15644117 15778339 15811952 15814715 16286920 16306937 16424049 16713974 16917499 17016554 17114424 17559085 1825141 18272812 19833085 20038811 20154735 20547845 20819927 21149606 21411734 23508573 24658051 26755705 2965306 6425450 9834059 9864217
NFKB1 IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 12759422 21642544 21243522 9374532 10227974 16481345 17556653 19732956 21224476 14662860 12757742 18690006 17407192
RELA IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 17035338 12759422 12105194 21243522 9374532 10227974 20643337 19929594 19732956 21224476 23195252 23667107 12842891 14662860 12757742 18690006 17407192 10075983
STAT5A IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12759422 7875295 7796811 15528362 9831114
STAT6 IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 17878383 10626890 7635985 10201928 16621996 10528163 10982806 24968940 22078635 9548487
STAT4 IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 12759422 12902482 14734615 19359411 23761633 15251440 20620946 11449378 12594853 12893768 10097133 20574006 25589075 19710469 11801649 26123499 15522880 9558063 9642277 16717115 24415943 17110450 16301617
IFNG IFNGR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 12915721 7673114 7514165 12438563 15530433 23331499 16237089 9111318 15143187 16467876 10986460 18988627 1396683 8550631 29145629 10811850 7617032 18591661 8631301 7615558 7510216 20304997
JAK2 IFNGR2 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
JAK2 IL6 â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
JAK2 TYK2 â—¼   PHYSICAL_INTERACTION 73.0 1.0 ACSN 10485906 10807786 11160275 11306493 11371360 11867689 11870632 12223527 12244147 12372421 12401408 12496409 12754507 12818165 1439146 14610620 14657224 15099563 15356132 15546391 15573129 16243976 16413922 17404308 17485448 18209571 18250477 1825141 18451175 18555777 18555778 19581928 19833085 20138012 20184663 20406969 20510870 20856220 21042762 21097505 21115385 21469115 21840487 22077060 22595692 23034983 23124025 23390297 23567181 24011634 24030977 24091328 24204259 24346288 24418198 25002027 25582338 26201938 26268945 26755705 27216177 27557510 2965306 7512720 7521688 7543512 7590867 8683106 8700208 8837607 9535722 9834059 9845545
JAK2 IL6 â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
JAK2 TYK2 â—¼   SHARES_COMPLEX 73.0 1.0 ACSN 10485906 10807786 11160275 11306493 11371360 11867689 11870632 12223527 12244147 12372421 12401408 12496409 12754507 12818165 1439146 14610620 14657224 15099563 15356132 15546391 15573129 16243976 16413922 17404308 17485448 18209571 18250477 1825141 18451175 18555777 18555778 19581928 19833085 20138012 20184663 20406969 20510870 20856220 21042762 21097505 21115385 21469115 21840487 22077060 22595692 23034983 23124025 23390297 23567181 24011634 24030977 24091328 24204259 24346288 24418198 25002027 25582338 26201938 26268945 26755705 27216177 27557510 2965306 7512720 7521688 7543512 7590867 8683106 8700208 8837607 9535722 9834059 9845545
JAK2 IFNGR2 â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
JAK2 IL18 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23390297 24030977 24091328 27216177 2965306 7512720 7521688 9834059
JAK2 STAT4 â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 10807786 11867689 12244147 12372421 14610620 15546391 19833085 20406969 21042762 21115385 22077060 24091328 24204259 27216177 7543512 8683106 8700208 9834059
JAK2 IL6 â—¼   ENZYMATIC_REACTION ✅ 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
JAK2 STAT6 â—¼   ENZYMATIC_REACTION ✅ 17.0 1.0 ACSN 11015446 11306493 11777960 11867689 12393492 12811837 14610620 19833085 20406969 20805416 21765015 22323450 22869907 23046136 24030977 24091328 27216177
STAT5A JAK2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10882725 7744007 21719533 19036881 9343435 9698919 11713228 19638583 16847321
IL1B JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10198225 7528775 9038232 8943050 9454765 7594594
IFNGR2 JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 7901766 23331499 23898330 7514165 16381926
JAK2 STAT4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 16324152
JAK2 STAT5B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 23331499 9047382 21071413 12538627 26959975 24354892 16306356 18988627 12456798 9575217 11682625
JAK2 STAT6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9852261 23331499 18852293 22992805
JAK2 STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 47.0 1.0 Omnipath 17081983 34197875 7925280 16497976 15795318 18083107 17389395 23331499 15504549 19534553 9047382 21071413 11641791 18988627 8617237 18250158 19088846 15256422 12529425 28676702 11413148 17016520 9575217
IFNB1 TYK2 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15312780 8943354 18508557 15449939 17969444 16171819
TYK2 IL6 â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
TYK2 IFNAR2 â—¼   PHYSICAL_INTERACTION 16.0 1.0 ACSN 11207245 11698286 11964292 12811837 14610620 14764699 15864272 17513775 19833085 21115385 21840487 21930765 21930769 7512720 7521688 7543512
TYK2 IFNAR1 â—¼   PHYSICAL_INTERACTION 16.0 1.0 ACSN 11207245 11698286 11964292 12811837 14610620 14764699 15864272 17513775 19833085 21115385 21840487 21930765 21930769 7512720 7521688 7543512
TYK2 IFNAR1 â—¼   SHARES_COMPLEX 16.0 1.0 ACSN 11207245 11698286 11964292 12811837 14610620 14764699 15864272 17513775 19833085 21115385 21840487 21930765 21930769 7512720 7521688 7543512
TYK2 IL6 â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
TYK2 IFNAR2 â—¼   SHARES_COMPLEX 16.0 1.0 ACSN 11207245 11698286 11964292 12811837 14610620 14764699 15864272 17513775 19833085 21115385 21840487 21930765 21930769 7512720 7521688 7543512
TYK2 STAT6 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10485906 11867689 12223527 12401408 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26755705 27216177 7512720 7521688 7543512 9535722
TYK2 IL18 â—¼   ENZYMATIC_REACTION ✅ 31.0 1.0 ACSN 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20856220 21115385 21840487 23124025 23390297 24030977 24091328 27216177 2965306 7512720 7521688 7543512 9834059
TYK2 STAT4 â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 10807786 11867689 12244147 12372421 14610620 15546391 19833085 20406969 21042762 21115385 22077060 24091328 24204259 27216177 7543512 8683106 8700208 9834059
TYK2 IL6 â—¼   ENZYMATIC_REACTION ✅ 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
IL1B TYK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10198225 7528775 9038232 8943050 9454765 7594594
IFNAR2 TYK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 12960323 12040185 18988627
TYK2 STAT5B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12411494 10830280 9872990 11751923
TYK2 IFNAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 45.0 1.0 Omnipath 9677371 8524272 24704786 14647450 7526154 16551269 21949722 23223197 16189514 9121453 8702790 9461596 8605876 7559568 12220192 21994561 15337770 8700538 20937132 8628273 18166147 95059042 9733772 10523853
TYK2 STAT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 8943354 18508557 8232552 17351669 12040185 7526154 9334213 23331499 10542297 24243840 23223197 11694501 15449939 18988627 15312780 8702790 8621447 17969444 8605876 10022928 32953130 21994561 1638633 16171819 29145629 18989459 34521819 8197134 16987978 10982844 8605877
RELA CCL5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 12820969 11478739 17510282 19786024 12050170 21138578 12122011 19828633 18367595 22030901 18502824 16707500 10926836 11413310 20663893 22388040 15144466 9120310 12603855 26096887 11259372 21189258 12388374 15972972 11389171 25523420 18525004
NFKB1 CCL5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 12820969 11413310 11478739 12122011 17065335 17510282 11700023 15144466 19786024 16707500 21189258 12388374 15972972 9120310 11389171 12050170 11259372
RELA IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 114.0 1.0 Omnipath 26596471 19124729 10373597 9523851 23595969 28270510 21537341 17982049 15226358 18243142 12200447 20371366 24664372 23874122 14532843 18942706 10975857 21278793 10469356 22547075 17490702 11459775 23335080 10569191 19707556 19687301 7499267 8290595 23857586 24676671 18061164 11058167 12887736 15013753 15158360 22661093 20935672 20511231 17350185 10903137 16112536 27413250 21810609 16984731 16166627 18469854 12881425 24012417 23386688 22105366 8752656 12176740 27371733 22578249 18057724 20351184 10329846 19164127 10542237 11564778 20221401 15517885 19122653 20534538 7876168 27211851 9516466 18996370 8824277 18310089 21104991 25888873 12359431 11327783 20066113 20100571 19703987 19469019 21106671 16960103 18502099 16043358 21996739 20650996 22021035 11120852 12672795 12058956 18483242 22189669 14976218 17495236 11007957 21131967 11975924 27337441 9182853 10963848 17040605 11504280 15756023 10823821 17932106 19966855 20696864 12177065 8679226 9199307 17196927 20457835 21098092 17532054
NFKB1 IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 71.0 1.0 Omnipath 17513725 18061164 12058956 24337575 19124729 15611045 11058167 9523851 15517885 12887736 15158360 7876168 17495236 25549935 17982049 15241416 18243142 9516466 2405250 18996370 8824277 18310089 24664372 15749903 10903137 16112536 14532843 11327783 18942706 11975924 20066113 16984731 10975857 11160296 19703987 22895549 10963848 10469356 22547075 17040605 11459775 17490702 19469019 8247545 11504280 15756023 10569191 10823821 20696864 12907458 19707556 16043358 11035101 12176740 11302724 8679226 8725624 22578249 8752656 17196927 17532054 12727841 18057724 7499267 10329846 9199307 9502421 19164127 11120852 24676671 11098847
RIPK3 GLUD1 â—¼   PHYSICAL_INTERACTION 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
GLUL GLUD1 â—¼   PHYSICAL_INTERACTION 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
MLKL GLUD1 â—¼   PHYSICAL_INTERACTION 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
GLUD1 PYGL â—¼   PHYSICAL_INTERACTION 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
GLUD1 PGAM5 â—¼   PHYSICAL_INTERACTION 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
GLUL GLUD1 â—¼   SHARES_COMPLEX 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
MLKL GLUD1 â—¼   SHARES_COMPLEX 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
RIPK3 GLUD1 â—¼   SHARES_COMPLEX 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
GLUD1 PGAM5 â—¼   SHARES_COMPLEX 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
GLUD1 PYGL â—¼   SHARES_COMPLEX 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
RIPK3 GLUD1 â—¼   ENZYMATIC_REACTION ✅ 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
GLUL GLUD1 â—¼   ENZYMATIC_REACTION ✅ 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
RIPK3 GLUL â—¼   PHYSICAL_INTERACTION 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
MLKL GLUL â—¼   PHYSICAL_INTERACTION 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
GLUL PGAM5 â—¼   PHYSICAL_INTERACTION 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
GLUL PYGL â—¼   PHYSICAL_INTERACTION 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
RIPK3 GLUL â—¼   SHARES_COMPLEX 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
MLKL GLUL â—¼   SHARES_COMPLEX 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
GLUL PGAM5 â—¼   SHARES_COMPLEX 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
GLUL PYGL â—¼   SHARES_COMPLEX 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
RIPK3 GLUL â—¼   ENZYMATIC_REACTION ✅ 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
MLKL GLUL â—¼   ENZYMATIC_REACTION ✅ 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
GLUL PGAM5 â—¼   ENZYMATIC_REACTION ✅ 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
GLUL PYGL â—¼   ENZYMATIC_REACTION ✅ 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
RIPK3 MLKL â—¼   PHYSICAL_INTERACTION 55.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16469705 16498403 16940415 17462996 17603935 18641653 19037093 19090789 19498109 19524512 19524513 19597341 19632174 19838173 20531300 20823910 20861672 21133840 21232017 22265414 22421439 22427918 23010170 23069999 23073834 23377657 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 26972597 27558815 27833036 27959630 27984721 28498367 28574505 28645028 9217161 9242610 9488730 9759866
CFLAR MLKL â—¼   PHYSICAL_INTERACTION 45.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19090789 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9242610 9488730 9759866
MLKL PYGL â—¼   PHYSICAL_INTERACTION 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
MLKL PGAM5 â—¼   PHYSICAL_INTERACTION 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
MLKL FAS â—¼   PHYSICAL_INTERACTION 43.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866
MLKL FASLG â—¼   PHYSICAL_INTERACTION 43.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866
CFLAR MLKL â—¼   SHARES_COMPLEX 45.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19090789 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9242610 9488730 9759866
RIPK3 MLKL â—¼   SHARES_COMPLEX 55.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16469705 16498403 16940415 17462996 17603935 18641653 19037093 19090789 19498109 19524512 19524513 19597341 19632174 19838173 20531300 20823910 20861672 21133840 21232017 22265414 22421439 22427918 23010170 23069999 23073834 23377657 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 26972597 27558815 27833036 27959630 27984721 28498367 28574505 28645028 9217161 9242610 9488730 9759866
MLKL FASLG â—¼   SHARES_COMPLEX 43.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866
MLKL FAS â—¼   SHARES_COMPLEX 43.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866
MLKL PYGL â—¼   SHARES_COMPLEX 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
MLKL PGAM5 â—¼   SHARES_COMPLEX 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
CFLAR MLKL â—¼   ENZYMATIC_REACTION ✅ 45.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19090789 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9242610 9488730 9759866
MLKL FASLG â—¼   ENZYMATIC_REACTION ✅ 43.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866
MLKL FAS â—¼   ENZYMATIC_REACTION ✅ 43.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866
RIPK3 MLKL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 27826146 24434512 25493335 26024392 28126382 26866270 34155344 27959630 24901049 27832137 26184911 30029665 26967968 29026104 24703947 28807105 27941671 23612963 24012422 29484439 22265413
RIPK3 PYGL â—¼   PHYSICAL_INTERACTION 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
PYGL PGAM5 â—¼   PHYSICAL_INTERACTION 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
RIPK3 PYGL â—¼   SHARES_COMPLEX 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
PYGL PGAM5 â—¼   SHARES_COMPLEX 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
RIPK3 CFLAR â—¼   PHYSICAL_INTERACTION 45.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19090789 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9242610 9488730 9759866
RIPK3 FASLG â—¼   PHYSICAL_INTERACTION 43.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866
RIPK3 FAS â—¼   PHYSICAL_INTERACTION 43.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866
RIPK3 PGAM5 â—¼   PHYSICAL_INTERACTION 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
RIPK3 FAS â—¼   SHARES_COMPLEX 43.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866
RIPK3 PGAM5 â—¼   SHARES_COMPLEX 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
RIPK3 CFLAR â—¼   SHARES_COMPLEX 45.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19090789 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9242610 9488730 9759866
RIPK3 FASLG â—¼   SHARES_COMPLEX 43.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866
RIPK3 FAS â—¼   ENZYMATIC_REACTION ✅ 43.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866
RIPK3 CFLAR â—¼   ENZYMATIC_REACTION ✅ 45.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19090789 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9242610 9488730 9759866
RIPK3 FASLG â—¼   ENZYMATIC_REACTION ✅ 43.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16498403 16940415 17462996 18641653 19498109 19524512 19524513 19597341 19632174 19838173 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 24366341 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866
CFLAR FASLG â—¼   PHYSICAL_INTERACTION 48.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16406523 16498403 16940415 17462996 18641653 19392652 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866
FASLG FAS â—¼   PHYSICAL_INTERACTION 53.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22075988 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9184224 9217161 9488730 9759866
CFLAR FASLG â—¼   SHARES_COMPLEX 48.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16406523 16498403 16940415 17462996 18641653 19392652 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866
FASLG FAS â—¼   SHARES_COMPLEX 53.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22075988 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9184224 9217161 9488730 9759866
CFLAR FASLG â—¼   ENZYMATIC_REACTION ✅ 48.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16406523 16498403 16940415 17462996 18641653 19392652 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866
NFKB1 FASLG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 14563113 12655294 15160330 16770006 10671224
FASLG FAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 39.0 1.0 Omnipath 17145710 8521815 9126929 1375228 1713127 14965271 21803845 9039262 11239407 25241761 9228058 15659383 12753742 7505205 12887920 15725726
CFLAR FAS â—¼   PHYSICAL_INTERACTION 48.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16406523 16498403 16940415 17462996 18641653 19392652 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866
CFLAR FAS â—¼   SHARES_COMPLEX 48.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16406523 16498403 16940415 17462996 18641653 19392652 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866
CFLAR FAS â—¼   ENZYMATIC_REACTION ✅ 48.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 15592525 15760909 16406523 16498403 16940415 17462996 18641653 19392652 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9217161 9488730 9759866
NFKB1 FAS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 11473033 16317104 10022897 16784892 7528667 19628709 9733827 10871852
TNFRSF10B CFLAR â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15024054 20696707 19278658 10837247 19416807 21235526
CFLAR TRADD â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15024054 20696707 19278658 10837247 19416807 21235526
NFKB1 CFLAR â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 11359904 15367674 21725609 23178297 23572150
NFKB1 CFLAR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19343319 15750764 18987666 18222423 15986355 15723831
RELA CFLAR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19343319 18073330 18222423 15986355 15723831
CFLAR CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 42.0 1.0 Omnipath 22864571 17145710 19416807 9217161 9326610 11741985 15280356 14585074 17047155 9794838 9208847 24438025 9289491 19710364 21737330 19343040 9228018 17159907 26186194 9380701 9880531 22421964 21737329 12887920 12215447 12097160 15024054
TNFRSF10B CASP8 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15024054 20696707 19278658 10837247 19416807 21235526
TLR3 CASP8 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 22421964 21737330 12752666 15814722 16115877 14739303 21737329 12181749
TLR4 CASP8 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 21737330 12752666 15814722 16115877 14739303 21737329
CASP8 TICAM2 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 21737330 12752666 15814722 16115877 14739303 21737329
TNFSF10 CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17145710 10894161 27821809 23678861
TRADD CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 17145710 15173123 20125124 12887920 10521396 20203691 21741934 14585074 17047155 22421964 19935698 11788820
TNFRSF10B CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17047155 12721308 12218097 22421964
TNFRSF10A CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 19427028 12218097 10894161 17047155 21785459 17898872 22421964
CASP8 CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 18073771 9545235 10872455 18329793 9727491 9463409
TLR4 CHUK â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15064760 15814722 16115877 16603398 16547522
CHUK TICAM1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15064760 15814722 16115877 16603398 16547522
CHUK TLR3 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15064760 15814722 16115877 16603398 16547522
CHUK TICAM2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15064760 15814722 16115877 16603398 16547522
CHUK RELA â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 9315679 9914500 9721103 10593898 9135156
CHUK NFKB1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 9315679 9914500 9721103 10593898 9135156
CHUK NFKBIB â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 9315679 9914500 9721103 10593898 9135156
EIF2AK2 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10723127 10648614
CHUK CYLD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19481526 24614225
CHUK RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 49.0 1.0 Omnipath 17145710 15611276 22110409 19609947 10521409 20863851 20051109 20363318 12767944 26999213 12842894 21903422 19110719 15858576 16382138 22155370 23894194 16046471 15128824 21569639 16846590 8246997 15485852 25341660 15494311 11983155 15980040 15489227 15849198 14636585 23343355
CHUK IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 91.0 1.0 Omnipath 9346484 24911653 20932476 28514442 11971985 16970925 12210728 9346485 17965022 16713569 12486103 9891086 15456791 11057907 20434986 16129692 16260493 21903422 21724995 16286467 14743216 16319058 18949366 10779355 25748427 25852190 12244103 11585904 9751060 15218526 10094049 10837071 9914500 21575199 9721103 25241761 10195894 9689078 15214841 21784860 17561400 21640763 16285893 10733566 16186825 16493424 10022904 12709429 12351658 10968790 12547194 15691841 15620648 15327770 11864612 11460167 14636585 17693255 17072322 9346241
CHUK NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 39.0 1.0 Omnipath 12482991 19442713 14743216 15494311 11976329 15489227 16382138 16713569 10022904 10469655 27554194 11158290 11297557
CHUK NFKBIB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 32.0 1.0 Omnipath 17145710 8657102 15084594 9315679 9252186 14743216 9278383 9914500 15836773 9721103 23109003 9689078 15145317 10723801 29145629 9135156 10593898 14636585 17072322 29695914
NFKB1 FTH1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 15537542 21725609 23178297 23572150
NFKB1 RELA â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
IKBKB RELA â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 9315679 9914500 9721103 10593898 9135156
RELA TNFRSF10B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18523266 18599488 19351839
RELA BIRC3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 15231833 15050749 19343319 17673602 18226221 23250755 17000776 11880364 21279667 21765477 10733571 18566231 12010810 15723831 10823821 11297551 16291753
RELA BIRC2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15050749 17673602 12687011 12714587 15756023 12010810 18566231 16453001 20103608
RELA IL1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 48.0 1.0 Omnipath 26596471 27338466 11114294 8413223 20975042 17707233 23383347 11058167 12686724 16433741 23667107 15382119 19122653 24009751 27211851 18566416 15292915 20617571 23056550 12517972 18285351 19843519 22267743 15812237 25161822 22388040 8021507 9878621 14960579 10963848 23195252 11395507 27534992 9058643 15543947 19846753 20696864 8679226 24908318 28389361 27371733 15972680 20336759 10080875 17082635
RELA NFKB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 16778171 20427719 23362108 16513645 1740105 20596645 16513841 19469019 8454856 21420936 16135789 9417120
RELA IFNA13 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 7957928 15331713 9446577 8035474
RELA CXCL10 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 23932714 20164184 15226358 16253303 25199798 16982926 19342664 10756005 23740952 17449583 16818736 19929594 22030901 19479051 24257594 21249144 24701034 20833730
RELA IFNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 23932714 15955070 22547704 19570999 10074115 21209118 17079305 7799921 17496231 15699120 12077266 8035474 17785777 12005436 24185615 10848607 16125763 9446577 20855868 24656046 23857586
NFKB1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 88.0 1.0 Omnipath 17145710 16209943 25609649 8428580 12947093 16970925 17072323 2050119 15657065 21270162 11976329 16793322 21544861 22261743 8657102 9824778 11880271 9450761 17962807 21988832 25355951 9722548 18215660 14743216 15799966 10799898 16105840 15218526 8798655 14690596 22139845 22808155 11571291 17072327 16740634 10498867 8255759 8246997 15214841 16846590 15371334 16285893 17072322 17855547 18321863 16493424 7479976 15145317 17561400 20110362 9426183 23687337 12414801 11970949 20154269 20237821 24175631 24634218 34100597 14645533 17982102 21763497 16204234 9437432 20547752 15818410 7628694
IKBKB RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 135.0 1.0 Omnipath 15280197 17785205 27329558 22110409 22753932 22205033 21765477 15611068 18519641 15858576 25241761 33579825 23536830 28122346 19393267 34556881 24442433 14560022 15192014 21242976 16840782 19609947 33789981 10521409 26826124 21492457 19110719 23303310 16105840 22212641 26587973 34219129 15210811 16046471 11359840 27626700 15128824 28416608 17178723 21674813 17362989 28737909 19377466 15980040 16407239 15849198 20507904 26082493 15557193 34082140 21798539 26267322 29363544 12767944 20224721 26307684 12842894 17108032 26170389 24336331 27315556 31980577 11259436 34380537 20872791 21674474 15465828 15994321 17548605 26603838 16148147 25136068 33914760 26569329 22234699 17012367 14636585 22039465 32123095 15212693 27466442 33883226 15611276 22081069 19197368 17070014 20051109 26693062 14963024 33971703 28381553 33459422 27244888 18544167 18922932 20188669 15485852 20696864 22689577 17982102 20410276 15489227
TBK1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 12842894 17562815 15128824 15485852 10521409 15489227 15849198 14560022 19958770 12767944
IL1B RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 25606026 26999213 22240205 23666959 19197368 25306394 24009751
RELA NFKBIB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 22081069 10497169 12672800 21988832 14685242 14743216 16189514 16226509 26186194 11571291 10498867 15371334 8816457 8887627 15145317 9135156 16513645 9597130 14636585
CASP1 IL18 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 22270365 17039247 15326478 9121587 9334240
IFNB1 IFNAR2 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 15312780 9121453 10395669 9334213 15778442 12842042 17969444
IFNAR2 IFNAR1 â—¼   PHYSICAL_INTERACTION 16.0 1.0 ACSN 11207245 11698286 11964292 12811837 14610620 14764699 15864272 17513775 19833085 21115385 21840487 21930765 21930769 7512720 7521688 7543512
IFNAR2 IFNAR1 â—¼   SHARES_COMPLEX 16.0 1.0 ACSN 11207245 11698286 11964292 12811837 14610620 14764699 15864272 17513775 19833085 21115385 21840487 21930765 21930769 7512720 7521688 7543512
IFNA5 IFNAR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10395669
IFNA4 IFNAR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21856167
IFNA2 IFNAR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 10395669 10339405 21854986 18027911 10984492 17001036 11888273
IFNA7 IFNAR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21856167
IFNA10 IFNAR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21856167
IFNB1 IFNAR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 8181059 10395669 7623815 11278538 1127853810395660
IFNA13 IFNAR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 8181059 10395669 11278538 11698684 21856167
IFNA16 IFNAR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21856167
IFNA17 IFNAR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 7623815 21856167
IRF9 IFNAR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17923090 18456457
IFNA21 IFNAR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21856167
IFNA8 IFNAR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10395669 8969169
IFNAR2 STAT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12220192 17923090 11786546 9121453 18456457
JAK3 STAT4 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 11418623 12517932 12244150 27774606 12093291 12759422
TLR4 IKBKB â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15064760 15814722 16115877 16603398 16547522
TLR4 TBK1 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 12692549 15210742 14530355 17526488 17047224 14703513 19656901 17823124 23453971
TLR4 TICAM1 â—¼   PHYSICAL_INTERACTION 11.0 1.0 ACSN 11672593 11964313 12032143 12811837 15644117 16306937 16917499 17114424 20154735 20547845 23508573
TLR4 TICAM1 â—¼   PROTEIN_INTERACTION 11.0 1.0 ACSN 11672593 11964313 12032143 12811837 15644117 16306937 16917499 17114424 20154735 20547845 23508573
TLR4 TRAF3 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11672593 11964313 12032143 12811837 15644117 16306937 16917499 17114424 20154735 20547845 23508573
TLR4 TICAM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 22139835 21903422 16410796 14556004 14517278 14519765 24265315 21829704 18221795 25736436 17258210
NFKB1 CXCL10 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 20164184 16253303 17274000 20579762 16982926 19342664 10756005 16818736 19929594 19479051 21249144 24701034
BIRC3 TRADD â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 35941131 22179575 22848449 23313255 24098568 34876703 16282325 20385093 22435550 18178551 19910467
BIRC2 TRADD â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 35941131 22179575 22848449 23313255 24098568 34876703 16282325 20385093 22435550 18178551 19910467
TNFRSF10A TRADD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9430228 9430227
TNFRSF10B TRADD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9430228 9430227
IFNB1 STAT2 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 15312780 9121453 10395669 9334213 15778442 12842042 17969444
STAT2 IRF9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 29145629 7537377 9242679 23331499 8621447 24065129 17923090 21903422 15978943 8943351 12590259 17351669 21178011 21268015
SHARPIN CYLD â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 26997266 27591049 27545878 24098568 27458237 27307491 22435550
NLRP3 IL1B â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 19104081 20385749 23202296 26885855 27048821 27066895 27439607 27984721
NFKB1 IL1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 8413223 17707233 11058167 12686724 16433741 18285351 8021507 9878621 14960579 10963848 9058643 15543947 20696864 8679226 11035101 15972680 20336759 18772363 10080875 17082635
CASP1 IL1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 1919001 7642516 7797510 17039247 28147281 8999548 19439663 9121587
IKBKB NFKB1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 9315679 9914500 9721103 10593898 9135156
NFKB1 TNFAIP3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 1332946 21725609 23178297 23572150
NFKB1 BIRC3 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 21725609 23178297 23572150 9294162 9733516
NFKB1 STAT5A â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 12208876 21725609 23178297 23572150
NFKB1 BIRC3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 15231833 15050749 19343319 17673602 17000776 11880364 10733571 9733516 18566231 12010810 15723831 10823821 11297551
NFKB1 IFNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 15955070 17079305 7799921 17496231 15699120 10074115 20855868 24656046 10848607 12077266 8035474 17785777 20048166 21209118 16125763 12005436 22427889 21343618
NFKB1 IFNA13 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 7957928 15331713 8035474
NFKB1 TNFRSF10B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18523266 18599488 19351839
NFKB1 BIRC2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15050749 17673602 12687011 15756023 9733516 12010810 18566231 16453001 20103608
NFKBIB NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 17145710 15836773 11571291 16513645 9597130 23109003 14743216 12670396 10497169 15371334 7867065 8816457 15145317 15084594
IKBKB NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 57.0 1.0 Omnipath 31598684 11976329 16713569 10469655 29485707 26999213 12842894 10835356 27187478 27402796 18782567 27554194 12482991 25241761 10022904 15199157 19519322 15489227 19250910 15212693 11158290 11297557
BIRC2 CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 16339151 9384571 16189514 11084335
IKBKB CYLD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 19481526 24614225 15870263
IKBKB TLR3 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15064760 15814722 16115877 16603398 16547522
IKBKB TICAM2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15064760 15814722 16115877 16603398 16547522
IKBKB TICAM1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15064760 15814722 16115877 16603398 16547522
IKBKB NFKBIB â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 9315679 9914500 9721103 10593898 9135156
TBK1 IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 10783893 21903422 21138416 10195894 14743216 16207722 10022904 14560022
MAVS IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 17145710 16177806 16153868 21903422 17468758 18207245
IKBKB NFKBIB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 39.0 1.0 Omnipath 17145710 10320352 9346485 8657102 15084594 9315679 10723127 14743216 28086098 15218526 9278383 11470788 9914500 15836773 9721103 23109003 9689078 15145317 9520401 10723801 17047224 29145629 9135156 10593898 14636585 9346484 17072322 9346241
TRAF3 TBK1 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 12692549 15210742 16306936 16281057 14530355 17526488 17047224 14703513 23453971
TICAM1 TRAF3 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11672593 11964313 12032143 12811837 15644117 16306937 16917499 17114424 20154735 20547845 23508573
TICAM1 TRAF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17327220 16306937 16306936 17991829 18450748 24577058 20418377
MAVS TRAF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 22901541 19893624 17020950 18818105 21200404 16306936 18207245 19546225 22844514 22792062 19193783 34610835 16858409
TRAF3 TBK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 27135603 15210743 16127453 15210742 16306936 12702806 23986588 22792062 16177806 20389019 17991829 20174559 16858409 23717208 34084167 22330071 17468758 17327220 24622840
STAT6 JAK3 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9651359 7796300 23124025 15805299 8085155
STAT6 ALOX15 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11509556 18799463 23285160 10657944 12517954
TBK1 STAT6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 30223576 22000020
MAPK8 STAT6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 21123173
IFNB1 IFNAR1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15312780 8943354 18508557 15449939 17969444 16171819
IFNA13 IFNAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 7932753 23331499 8181059 11698684 21856167
IFNB1 IFNAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 23331499 8181059 1834641 10049744 7592797 7623815 11278538 18988627 29311663 112785381834641
IFNA7 IFNAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21856167
IFNA4 IFNAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21856167
IFNA10 IFNAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21856167
IFNA16 IFNAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21856167
IFNA2 IFNAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 7592797 9334213 1834641
IFNA17 IFNAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 7623815 21856167
IFNA21 IFNAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21856167
IFNA8 IFNAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 7592797 21856167
IFNA5 IFNAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21856167
TLR3 TICAM1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 14517278 12539043 12242293 12855817 14982987 12609980
TICAM2 TICAM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17145710 12721283 16410796 24255114 14519765
TLR3 TICAM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 12471095 12539043 15932500 16410796 14982987 14751757 14519765
TICAM1 TBK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 20200155 19416887 21903422 14530355 14739303 16410796 19656901 20418377 29018427 16281057
CHMP1A VPS4A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 17928862 16730941 23045692 14505570 11559748
MAPK8 CTBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 28532298 14567915 17496919 19591900 21372320 19788416 15708980 8608010 16984892 20512932 20220133 21438496 20054826 19616017 23762064 15611655
TLR3 TBK1 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 12692549 15210742 16306936 16281057 14530355 17526488 17047224 14703513 23453971
TICAM2 TBK1 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 12692549 15210742 14530355 17526488 17047224 14703513 19656901 17823124 23453971
MAVS TBK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 21813773 15210743 16127453 33372174 17020950 25636800 21903422 15210742 16753195 16306936 12702806 24643253 16177806 27419230 16153868 16858409 29743353 17468758 17327220
TBK1 STING1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 25254379 22579474 24929887 24119841 26199418 25815785 27857881 21074459 33723219 21903422 33906974 29899553 30018345 29241549 23542348 30193098 19416887 18818105 22394562 29202128 33789998 19433799 18724357 24622840
MAVS STING1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 19416887 18818105 20080758 20019757 22312431 22844514 23542348 18724357 24622840 22911572
TNFSF10 TNFRSF10B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 50.0 1.0 Omnipath 22266862 14585074 21459798 19427028 15538968 9325248 10894161 11239407 16189514 12628743 21525171 23678861 10549288 20103630 11094155 16227629 10542098 10894160 22585859 21822306 9242610 9311998 15766588 20097879
TNFRSF10A TNFRSF10B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9430228 16319225
JAK3 STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23331499 18250158 9382798 10037026 19088846 9047382 7777534 16189514 19414780
BIRC3 CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16339151 9384571
IRF9 IFNA13 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 20403236 9186002 22252317 15145216 22626811 8864350
TNFSF10 TNFRSF10A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 9314565 9613612 14585074 19427028 15538968 9325248 10894161 11239407 16189514 12628743 10549288 20103630 10894160 9082980 9242610 9311998 15766588 9430226
CTBP1 TCF7L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12711682
CASP1 MEFV â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16785446 16037825 17431422 18577712