ESR1
|
EP300
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16704985
11279135
|
EP300
|
RELA
|
â—¼ ACETYLATION
|
✅
|
|
2.0
|
0.8
|
intact
|
5214468
11533489
|
PRKAR1A
|
PYCARD
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16189514
5217968
|
SMARCA5
|
CENPA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
19410539
19398759
|
CBX8
|
H3C2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
18927235
0805317105
|
CBX8
|
BMI1
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
17332741
5219708
|
CBX8
|
RNF2
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
17332741
5219708
|
HSPA5
|
RIPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
HSPA8
|
RIPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
RELA
|
MAP3K14
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15047705
22685329
|
FOS
|
RELA
|
â—¼ PROXIMITY
|
|
|
2.0
|
0.8
|
intact
|
18172215
0705181105
|
MAP3K14
|
RELA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18439422
|
RELA
|
FOS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16189514
10488148
|
FOS
|
HSPA5
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11719466
10472808
|
FOS
|
FOXA1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
22577344
|
ESR1
|
BMI1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
24559156
16582100
|
HSPA8
|
MAP3K14
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
HSPA8
|
SRRT
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
22365833
8293266
|
ESR1
|
HSPA8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11085516
|
FBL
|
MAP3K14
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
HSPA5
|
MAP3K14
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
HNRNPA1
|
MAP3K14
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
HNRNPA1
|
MAST1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
000924
30021884
|
HSPA5
|
MAST1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
000924
30021884
|
CBX8
|
CBX3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
34079125
24981860
|
ESR2
|
DDB1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
29509190
25604459
|
CENPA
|
CENPH
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
16622419
15009096
|
CENPO
|
CENPH
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
26496610
16622420
|
CENPU
|
CENPK
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
16622419
26496610
|
FOS
|
ESR1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
17317669
25303530
|
BMI1
|
SRRT
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
24457600
34316702
|
BMI1
|
FBRL
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
24457600
34316702
|
BMI1
|
RNPS1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
24457600
34316702
|
RNPS1
|
KIF23
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
31586073
26496610
|
CENPA
|
CENPI
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
34079125
15009096
|
CENPA
|
CENPM
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
16622419
15009096
|
CENPA
|
CENPB
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
16622419
15009096
|
CHC10
|
LUC7L
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
RNPS1
|
ZFP91
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
17353931
33961781
|
CENPU
|
CENPC
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
CENPM
|
CENPO
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
16622419
26496610
|
CENPO
|
CENPI
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
26496610
16622420
|
TR13B
|
ZFP91
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
FBRL
|
ZFP91
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
26186194
|
AKIP
|
ZFP91
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
PRDM5
|
ZFP91
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
CLC3A
|
ZFP91
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
CHC10
|
ZFP91
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
BHA15
|
ZFP91
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
ESR2
|
EP300
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
11500849
18765668
|
CENPH
|
CENPK
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
32296183
25416956
16622420
33961781
24981860
|
CENPH
|
CENPU
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
26496610
21454580
33961781
24981860
16622419
|
CENPA
|
CENPU
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
34079125
16622419
21454580
|
LUC7L
|
UBE2O
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
26186194
|
LUC7L
|
SRRT
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
26186194
|
LUC7L
|
ZFP91
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
26186194
|
CENPO
|
CENPU
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
26496610
16622420
33961781
26186194
16622419
|
CENPU
|
CENPM
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
16622419
26496610
24981860
|
CENPU
|
CENPI
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
26496610
24981860
33961781
16622419
|
CASQ2
|
ZFP91
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
26186194
|
EP300
|
FOS
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
19064921
21937452
11287611
24069158
|
ESR1
|
FOXA1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
28336670
23403292
25303530
27926873
|
SUPT16H
|
SSRP1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.85
|
0.85
|
mint
|
5218941
16902406
|
EP300
|
FOS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
850.0
|
0.85
|
STRING
|
36370105
|
RSF1
|
SMARCA5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
857.0
|
0.85
|
STRING
|
36370105
|
ESR1
|
MEN1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
16651450
31527615
|
FOS
|
CENPO
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
25416956
25609649
|
RACGAP1
|
KIF23
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.86
|
0.86
|
mint
|
8397056
22580824
|
CBX3
|
RING1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
27705803
33961781
12004135
24981860
|
CENPA
|
SSRP1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
28514442
16622419
34079125
|
CENPA
|
RSF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
34079125
24800743
15009096
|
AKIP
|
UBE2O
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
28514442
33961781
29568061
|
CENPO
|
CENPU
|
â—¼ PHYSICAL_INTERACTION
|
|
|
870.0
|
0.87
|
STRING
|
36370105
|
ESR1
|
ESR2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
873.0
|
0.87
|
STRING
|
36370105
|
CENPH
|
CENPU
|
â—¼ PHYSICAL_INTERACTION
|
|
|
876.0
|
0.87
|
STRING
|
36370105
|
ESR1
|
HSPA8
|
â—¼ PHYSICAL_INTERACTION
|
|
|
880.0
|
0.88
|
STRING
|
36370105
|
RACGAP1
|
SHCBP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
881.0
|
0.88
|
STRING
|
36370105
|
CENPI
|
CENPU
|
â—¼ PHYSICAL_INTERACTION
|
|
|
884.0
|
0.88
|
STRING
|
36370105
|
RING1
|
RNF2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
885.0
|
0.88
|
STRING
|
36370105
|
CUL4A
|
CRBN
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
28514442
24292623
24292625
31973889
32235678
23983124
26231201
25860244
26990986
27029275
33961781
16964240
32132601
21145461
27142104
20223979
27294876
|
CENPA
|
CENPC
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
34079125
16622419
19503796
|
RNPS1
|
LUC7L
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
28514442
17353931
33961781
26186194
|
CUL4A
|
DDB1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
22952844
17079684
22118460
15448697
26613412
22910413
25349427
21145461
22474075
27462452
16473935
15811626
18606781
26231201
18593899
16678110
16964240
33536335
19295130
25982117
33759138
16260596
27113764
21113133
30898011
28886238
26976604
27203177
17392787
25795299
22939629
26344197
14739464
27294876
10585395
27573245
31911655
17041588
20870715
27203182
31973889
32235678
16861906
19966799
22342275
34251884
17626091
19287380
30945288
16949367
32140073
|
DDB1
|
CRBN
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
23983124
29370161
28425720
24292625
26909574
26231201
25108355
25860244
16964240
27142104
24292623
26990986
30190590
27294876
26131937
32235678
29892083
27338790
32132601
20223979
|
EP300
|
ESR1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
19887647
11782371
12738788
25728767
11867769
12479814
23065768
15308690
20388208
14761960
22227247
8799122
20348541
23403292
12714702
11581164
16713569
19838210
18765668
16645043
30418174
12574227
|
CBX8
|
BMI1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
21282530
34316702
20543829
10825164
20601937
19636380
26496610
27705803
22325352
33961781
24981860
17332741
24457600
|
ESR2
|
FOS
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
20155458
10037443
|
RING1
|
BMI1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
16189514
9858531
25416956
29402932
19451220
32296183
22493164
22897849
15386022
16751658
20601937
19636380
16359901
34316702
24457600
9199346
27705803
34133714
22325352
33961781
24981860
|
ESR2
|
ESR1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
29509190
12630920
17991765
21182203
19022902
10706629
19746436
9473491
|
FOXA1
|
ESR1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
21572391
20501593
24290378
|
CRBN
|
CUL4A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
911.0
|
0.91
|
STRING
|
36370105
|
CENPH
|
CENPK
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.91
|
0.91
|
HuRI
|
32296183
|
RING1
|
CBX8
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.92
|
0.92
|
mint
|
24981860
|
RNF2
|
CBX8
|
â—¼ COLOCALIZATION
|
✅
|
|
0.92
|
0.92
|
mint
|
5219708
17332741
|
EP300
|
RELA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
922.0
|
0.92
|
STRING
|
36370105
|
WTAP
|
ZC3H13
|
â—¼ PHYSICAL_INTERACTION
|
|
|
928.0
|
0.92
|
STRING
|
36370105
|
EP300
|
ESR1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
930.0
|
0.93
|
STRING
|
36370105
|
BMI1
|
CBX8
|
â—¼ PHYSICAL_INTERACTION
|
|
|
948.0
|
0.94
|
STRING
|
36370105
|
CBX8
|
BMI1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.96
|
0.96
|
mint
|
5219708
17332741
|
BMI1
|
CBX8
|
â—¼ COLOCALIZATION
|
✅
|
|
0.96
|
0.96
|
mint
|
5219708
17332741
|
RING1
|
BMI1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.96
|
0.96
|
mint
|
24981860
|
RNF2
|
BMI1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.96
|
0.96
|
mint
|
16710298
5218667
|
BMI1
|
RING1
|
â—¼ COLOCALIZATION
|
✅
|
|
0.96
|
0.96
|
mint
|
7998286
20601937
|
CBX8
|
RNF2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
961.0
|
0.96
|
STRING
|
36370105
|
CBX8
|
RING1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
963.0
|
0.96
|
STRING
|
36370105
|
CBX8
|
RING1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
21282530
25416956
32296183
10825164
20601937
26496610
27705803
24981860
|
BMI1
|
RING1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
972.0
|
0.97
|
STRING
|
36370105
|
CRBN
|
DDB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
986.0
|
0.98
|
STRING
|
36370105
|
KIF23
|
RACGAP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
994.0
|
0.99
|
STRING
|
36370105
|
SSRP1
|
SUPT16H
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
CBX3
|
H3C2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
15136563
20871592
20011120
24576085
19111658
16415788
26527279
|
CUL4A
|
DDB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
999.0
|
1.0
|
STRING
|
36370105
|
DDB1
|
CUL4A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
19.0
|
1.0
|
ACSN
|
11900249
12648680
12820959
15071497
15340381
15459660
15688063
1570337
15703371
16697054
17884153
18931676
19270156
19557001
19622404
19686080
19809470
19847258
20211143
|
DDB1
|
CUL4A
|
â—¼ SHARES_COMPLEX
|
|
|
19.0
|
1.0
|
ACSN
|
11900249
12648680
12820959
15071497
15340381
15459660
15688063
1570337
15703371
16697054
17884153
18931676
19270156
19557001
19622404
19686080
19809470
19847258
20211143
|
EP300
|
RELA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
25.0
|
1.0
|
Omnipath
|
19608861
25400040
11567019
12419806
17617622
11533489
20333651
12456660
15152190
16846590
9096323
20064247
16382138
16713569
15171256
16135789
|
EP300
|
H3C2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
21875947
19270680
19158375
20587414
|
MEN1
|
RELA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
9.0
|
1.0
|
Omnipath
|
11526476
14508515
16713569
|
RSF1
|
SMARCA5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
17145710
18519663
20923775
26666816
12972596
|
SSRP1
|
ESR1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
15171726
23810005
1406642
19946334
|
RIPK1
|
MAP3K14
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
11116146
15047705
|
ESR1
|
FOS
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
8114761
9528985
18414489
10037443
21813366
11726205
|
BMI1
|
RNF2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
999.0
|
1.0
|
STRING
|
36370105
|
BMI1
|
RNF2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
39.0
|
1.0
|
Omnipath
|
16710298
22493164
22902369
20068231
22325352
25355358
17157253
16751658
26496610
16714294
26468281
26151332
12183370
12589020
21772249
25843776
20601937
32296183
21676867
27647897
15563468
27705803
16359901
24457600
19636380
|
ESR2
|
ESR1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
15.0
|
1.0
|
Omnipath
|
14754635
24284820
15207704
18784357
11566442
12630920
22820289
19001520
18511514
14676837
19207817
22622808
21763263
18339713
15087130
|
ESR1
|
ESR2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
23331499
12630920
9473491
19746436
21182203
10706629
10022879
|
FOXA1
|
H3C2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
14.0
|
1.0
|
Reactome
|
18533032
27062924
21151129
16009131
16087863
16980581
21934649
16113099
18358809
22056668
23172872
15282324
21878914
23192763
|