KSR2
|
BRAF
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
22510884
8396417
|
ARAF
|
HSP7C
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
31980649
29777862
|
MP2K2
|
BAG2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
33961781
31980649
|
BAG2
|
RAF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
25036637
31980649
|
MP2K2
|
CDC37
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
33961781
31980649
|
CDC37
|
TBB5
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
34079125
24189400
|
1433T
|
KSR1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
CD70
|
MP2K2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
MP2K2
|
HS905
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
MP2K2
|
TBB5
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
33961781
31980649
|
MP2K2
|
HS90B
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
33961781
31980649
|
MP2K2
|
H90B4
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
MP2K2
|
TBA1C
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
33961781
31980649
|
PAI2
|
MP2K2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
MP2K2
|
HS90A
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
33961781
31980649
|
MP2K2
|
HS904
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
MP2K2
|
H90B3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
MP2K1
|
HSP7C
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
27684187
17979178
|
ARAF
|
BAG2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
29777862
31980649
25852190
|
CDC37
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
829.0
|
0.83
|
STRING
|
36370105
|
HS90A
|
BRAF
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
27034005
31980649
22939624
28146421
27684187
|
MP2K2
|
TBA4A
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
31980649
|
HSP7C
|
MP2K2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
31980649
|
HSP7C
|
1433T
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
27684187
15324660
|
HSP7C
|
TBB5
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
27684187
25864199
26344197
|
MP2K2
|
1433F
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
32707033
31980649
|
MP2K2
|
1433T
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
32707033
31980649
|
MP2K1
|
1433T
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
32707033
31980649
|
1433B
|
ARAF
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
31980649
29777862
24255178
25852190
32707033
|
HS90A
|
ARAF
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
22939624
32707033
31980649
29777862
|
ARAF
|
HS90B
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
25036637
31980649
29777862
22939624
32707033
|
ARAF
|
1433T
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
32707033
29777862
31980649
25852190
|
RAF1
|
HSP7C
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
20039095
31980649
16093354
|
HS90A
|
KSR2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
22939624
32707033
27086506
25036637
|
KSR2
|
MP2K2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
32707033
27086506
33961781
|
1433B
|
MP2K2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
32707033
31980649
24255178
10409742
|
1433F
|
MP2K1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
28514442
32707033
33961781
31980649
|
ARAF
|
RAF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
31980649
34017080
20130576
|
BRAF
|
CDC37
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
27034005
31980649
17979178
33961781
27684187
|
1433F
|
KSR1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
28514442
17979178
33961781
|
BRAF
|
HSP7C
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
27684187
17979178
31980649
|
BRAF
|
HS90B
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
22939624
27684187
17979178
31980649
|
TBA1C
|
TBA4A
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
28514442
22863883
33961781
22939629
|
TBA4A
|
TBB5
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
22863883
33961781
34079125
22939629
26344197
|
ARAF
|
BRAF
|
â—¼ PHYSICAL_INTERACTION
|
|
|
873.0
|
0.87
|
STRING
|
36370105
|
CDC37
|
ARAF
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
25036637
31980649
29777862
24189400
33961781
32707033
|
RAF1
|
CDC37
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
25036637
31980649
24189400
24292678
17979178
33961781
32707033
16611982
16335536
|
BRAF
|
RAF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
23153539
28514442
31980649
18332145
20141835
23934108
31015455
11325826
23680146
20130576
26466569
22169110
33961781
34017080
28806393
20212043
25155755
22605333
|
BRAF
|
1433F
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
28514442
27034005
31980649
17979178
33961781
32707033
|
MP2K1
|
1433B
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
31980649
17979178
24255178
10409742
32707033
|
MP2K1
|
MP2K2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
28514442
32707033
33961781
10409742
|
HS905
|
HS90A
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
22939629
33961781
|
H90B3
|
HS90A
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
22939629
33961781
|
HS905
|
HS90B
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
22939629
33961781
|
1433F
|
ARAF
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
28514442
11969417
29777862
17979178
26496610
33961781
25852190
32707033
|
RAF1
|
HS90A
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
16189514
31980649
24462205
22939624
28537252
28146421
17699868
19011619
8408024
16335536
23118896
25036637
16330544
27703006
16504566
8962087
20159553
32707033
20039095
17409432
15618521
16093354
|
RAF1
|
1433F
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
28514442
11969417
31980649
11697890
10620507
17979178
26496610
8702721
16041367
33961781
16093354
25852190
32707033
|
RAF1
|
HS90B
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
31980649
16330544
17979178
34017080
22939624
32707033
|
1433B
|
KSR1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
28514442
33961781
24255178
|
BRAF
|
MP2K2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
28514442
27034005
31980649
24746704
17979178
33961781
25600339
32707033
|
KSR2
|
MP2K1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
32707033
12975377
27086506
33961781
|
1433F
|
1433T
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
28514442
17979178
26496610
20618440
22863883
33961781
|
HS90B
|
HSP7C
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
25864199
29930177
26344197
|
TBA1C
|
TBB5
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
26496610
22863883
33961781
34079125
26344197
|
BRAF
|
ARAF
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
28514442
25241761
31980649
28628118
17979178
20130576
34017080
33961781
28205554
|
MP2K2
|
ARAF
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
32296183
16189514
31980649
21988832
24746704
11909642
25852190
32707033
|
ARAF
|
MP2K1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
8621729
8394352
31980649
24746704
17979178
26496610
24114843
8157000
32707033
7731720
|
BAG2
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
14978028
12502846
8692945
|
1433B
|
RAF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
28514442
16189514
31980649
10620507
7935795
7882972
25852190
19595761
7644510
11697890
12360521
32707033
8085158
8702721
10848612
16041367
33961781
16093354
12620389
24255178
|
1433T
|
RAF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
28514442
31980649
7760835
11697890
17353931
10620507
15618521
16041367
7479742
33961781
8663231
16093354
25852190
32707033
10757792
|
1433B
|
BRAF
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
28514442
27034005
10931830
32707033
31980649
17353931
33961781
24255178
12620389
27684187
15324660
|
1433T
|
BRAF
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
28514442
27034005
32707033
31980649
18332145
17353931
17979178
31015455
33961781
27684187
15324660
|
BRAF
|
MP2K1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
28514442
31980649
23934108
19371126
27684187
16888650
18332145
9733801
26496610
31015455
25437913
25600339
24746704
17979178
32707033
16810323
27034005
33961781
20212043
25155755
|
HSP7C
|
HS90A
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
27708256
16189514
25864199
22504172
26344197
9269769
21360678
20039095
19875381
|
MK01
|
RAF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.92
|
0.92
|
HIPPIE
|
10958680
16093354
15664191
19058874
11409918
|
MK03
|
RAF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.92
|
0.92
|
HIPPIE
|
11409918
9446616
19058874
|
BRAF
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
935.0
|
0.93
|
STRING
|
36370105
|
RAF1
|
MP2K2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.95
|
0.95
|
HIPPIE
|
16189514
31980649
21988832
24746704
8393135
9671314
11909642
8157000
9808624
16364241
19058874
32707033
|
KSR1
|
MP2K1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.95
|
0.95
|
HIPPIE
|
27086506
11940661
31980649
18332145
15090600
17979178
11741534
26496610
32707033
15520859
|
KSR1
|
MP2K2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.95
|
0.95
|
HIPPIE
|
11909642
32707033
27086506
31980649
|
RAF1
|
BRAF
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.96
|
0.96
|
mint
|
8396417
22510884
|
MK03
|
MK01
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.96
|
0.96
|
HIPPIE
|
31980649
16424009
33961781
19058874
23602568
32707033
23397142
26344197
|
MP2K2
|
MK03
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.96
|
0.96
|
HIPPIE
|
7687743
9006895
8226933
8626767
|
1433F
|
1433B
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.96
|
0.96
|
HIPPIE
|
28514442
17979178
26496610
33961781
24255178
26344197
|
1433T
|
1433B
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.96
|
0.96
|
HIPPIE
|
28514442
17085597
20618440
22863883
33961781
24255178
|
HSP7C
|
BAG2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
25036637
18457437
22365833
9873016
33961781
30021884
27684187
26344197
29568061
16207813
|
CDC37
|
HS90B
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
25036637
28215707
24189400
23428871
26496610
22939624
33961781
27339980
11036079
25486457
|
CDC37
|
HS90A
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
24292678
24462205
22939624
14718169
15647277
16335536
21871133
25036637
26496610
21745565
25486457
12176997
22729780
24189400
22504172
22315411
26804907
11413142
12930845
20159553
15001580
19875381
27353360
9685350
33961781
16611982
21360678
|
RAF1
|
MP2K1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
15866172
31980649
10958680
23934108
15485920
11604401
19058874
34407391
18556463
9733801
26496610
9311917
10757792
8621729
7527398
27703006
24746704
17979178
1326789
34017080
17724343
32707033
8394352
19197339
8157000
16093354
20212043
25155755
7731720
21336309
|
MK03
|
MP2K1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
10748187
9006895
8626767
9733512
19197339
8226933
19058874
34497368
|
HS90A
|
HS90B
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.98
|
0.98
|
HIPPIE
|
25036637
31536960
20353823
26496610
22863883
26344197
33961781
21360678
19875381
|
MP2K2
|
MK01
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.99
|
0.99
|
HIPPIE
|
23519423
11134045
12788955
11823456
21675959
|
RAF1
|
KSR1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
25435214
20179705
20141835
16364920
20130576
15035987
25907612
|
KSR1
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
33.0
|
1.0
|
Omnipath
|
7477354
12932319
9665134
9094715
19766101
23331499
8601312
19595761
11478855
8332195
15520859
8503013
16093354
19541618
19933846
10205168
7760835
18775988
18789263
11134016
8180183
1990291
|
KSR2
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
12975377
23331499
|
KSR1
|
BRAF
|
â—¼ PHYSICAL_INTERACTION
|
|
|
47.0
|
1.0
|
ACSN
|
10086337
10567412
10811803
10843677
10982827
11034387
11062502
11385609
11447289
11777939
11907067
12040186
12175651
12419216
12640133
12782630
14585353
14764585
15169888
15536084
15547943
15567848
15574420
15735649
15863030
16102570
16227978
16488589
16582911
16887996
17178906
17395718
17496910
17613518
17673906
19449109
19541618
19565474
19568798
19615955
21102635
22435554
24027568
26552706
7510700
8551221
9510155
|
KSR1
|
BRAF
|
â—¼ SHARES_COMPLEX
|
|
|
47.0
|
1.0
|
ACSN
|
10086337
10567412
10811803
10843677
10982827
11034387
11062502
11385609
11447289
11777939
11907067
12040186
12175651
12419216
12640133
12782630
14585353
14764585
15169888
15536084
15547943
15567848
15574420
15735649
15863030
16102570
16227978
16488589
16582911
16887996
17178906
17395718
17496910
17613518
17673906
19449109
19541618
19565474
19568798
19615955
21102635
22435554
24027568
26552706
7510700
8551221
9510155
|
KSR1
|
BRAF
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
19541618
8601312
19933846
12932319
17613518
18332145
15710605
|
MK01
|
MP2K1
|
â—¼ PROTEIN_INTERACTION
|
|
|
1.0
|
1.0
|
HIPPIE
|
11279118
12697810
11741894
27884160
11352917
11134045
12594221
11823456
11266467
12788955
24623782
8157000
19058874
17255949
21675959
23241949
21336309
10757792
|