Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
Graph tools:

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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
PAPPA ATF7IP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
PPARG IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19160541 15187132
IGFBP1 IGF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0605652103 16924115
IGFBP4 IGF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9722589 16189514
IGFBP5 IGF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9497324 16189514
IGFBP5 IGFALS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9786878 9497324
TP53 IGFBP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11672436 18056423
PAPPA IGFBP4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9751498 12241545
SMAD9 PAPPA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
PLEC PAPPA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
SKIL PAPPA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD3 PAPPA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD2 PAPPA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD9 PLEC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD2 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21836474 21926264
TNF PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22078880 20651683
SMAD9 SMAD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD9 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15231748
TP53 SMAD3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21900401
SMAD2 SMAD9 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 15231748
SMAD3 SMAD9 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
SMAD2 TP53 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
SMAD2 SKIL â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 15231748 10531062 11691834 16959829 12764135 12426322 18729074 22442258 25059663
SMAD3 SKIL â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 15231748 10531062 17469184 11691834 16959829 11306568 12764135 12426322 22442258
SKIL SMAD3 â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
SKIL SMAD2 â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
SMAD2 SMAD3 â—¼   PHYSICAL_INTERACTION 899.0 0.89 STRING 36370105
PPARG IGF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18394717 20064783 20685873
IGFBP1 IGF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10350456 22578544
IGFBP1 IGF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10810289 22578544
IGF2 IGFBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10810289 22578544
PPARG TNF â—¼   DOWN_REGULATES ✅ - 3.0 0.9 ACSN 10432118 17681149 23390297
PPARG TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16887883 14960510
IGFBP1 IGFBP4 â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
IGF1 IGFBP5 â—¼   PHYSICAL_INTERACTION 945.0 0.94 STRING 36370105
IGF1 IGFBP1 â—¼   PHYSICAL_INTERACTION 959.0 0.95 STRING 36370105
IGF1 IGFBP4 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
PLG IGF1 â—¼   CLEAVAGE ✅ 10.0 1.0 Reactome 8817670 7527330 17047378 8964575 11739083 7588299 8894645 12466191 12379487 10990447
PLG IGF2 â—¼   CLEAVAGE ✅ 10.0 1.0 Reactome 8817670 7527330 17047378 8964575 11739083 7588299 8894645 12466191 12379487 10990447
PLG IGFALS â—¼   CLEAVAGE ✅ 10.0 1.0 Reactome 8817670 7527330 17047378 8964575 11739083 7588299 8894645 12466191 12379487 10990447
SMAD3 IFNG â—¼   DOWN_REGULATES ✅ - 25.0 1.0 ACSN 10925299 11074002 11279127 11399519 11792802 11875494 12193690 12702545 12809600 15265520 15644117 16127449 16179589 16713975 17260466 17689680 18768831 21042762 21614932 22331441 23390297 6357187 8515656 8871614 9389648
SMAD2 IFNG â—¼   DOWN_REGULATES ✅ - 24.0 1.0 ACSN 10925299 11074002 11279127 11399519 11792802 11875494 12193690 12702545 12809600 15265520 15644117 16127449 16179589 16713975 17260466 17689680 21042762 21614932 22331441 23390297 6357187 8871614 9389648 9670020
TP53 IGF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12631625 18281476 18174288 21460853
IGF1 PAPPA â—¼   CLEAVAGE ✅ 10.0 1.0 Reactome 10077652 10898936 12904166 11158056 17249697 17312271 12379487 12241545 12466191 17047378
IGFBP4 IGF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 9722589 7683646 16924115 15642270
IGFBP5 IGF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 9497324 1147105 15642270
IGF2 IGFALS â—¼   PHYSICAL_INTERACTION 22.0 1.0 Reactome 11788658 11316783 7689487 15469690 9497324 10026136 12379487 7543116 17047378 10681634 11250653 7683646 10810289 1370451 12466191 15126567 9709957 7519608 2476804 15485880 12810533 8781553
IGF2 PAPPA â—¼   CLEAVAGE ✅ 10.0 1.0 Reactome 10077652 10898936 12904166 11158056 17249697 17312271 12379487 12241545 12466191 17047378
IGFALS PAPPA â—¼   CLEAVAGE ✅ 7.0 1.0 Reactome 11788658 17047378 11606061 12379487 11264294 12466191 11522292
IGFBP5 IGFALS â—¼   PHYSICAL_INTERACTION 14.0 1.0 Reactome 8781553 11788658 7519608 10614670 11316783 9497324 7683646 10810289 7689487 12379487 9786878 12466191 15126567 17047378
PGR IGFBP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12489992 9178756 10459849 15987820 11117526
IGFBP4 PAPPA â—¼   CLEAVAGE ✅ 10.0 1.0 Reactome 10077652 10898936 12904166 11158056 17249697 17312271 12379487 12241545 12466191 17047378
IGFBP5 PAPPA â—¼   CLEAVAGE ✅ 7.0 1.0 Reactome 11788658 17047378 11606061 12379487 11264294 12466191 11522292
SMAD3 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21836474 21926264 12457461 12524424
PPARG TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 20376096 11009565 14646597 20473515 11124825 17532302 17464333 19031802 14656714
SKIL SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 12764135 15221015 23331499 18729074 22442258 25059663 16959829 18334480 10531062 17510063 15496141 12793438 15231748 11691834 12426322
SKIL SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 12764135 23331499 21071413 22442258 11306568 16959829 10531062 12793438 17469184 15231748 11691834 12426322
SMAD3 SMAD2 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10454538 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23869868 8515656 9312026 9389648 9618481 9670020 9865696
SMAD2 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 21988832 26186194 12543979 9111321 15084259 9311995 25878769 18729074 12700238