Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
AP2B1 CD74 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 15749704 15911768
SP1 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
GRB2 PRKDC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 HSPA8 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 AP2B1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 PPP6R3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
NCOA6 KDM6A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0810100105 19047629
PRKDC NFKBIE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
LRRK2 DYRK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29513927 201700444
HSPA8 PRKAA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 26902588 25961502
SP1 HDAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12847090 5216518
RCHY1 HDAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16914734
TERF2IP AP2B1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
LRRK2 LATS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29513927 201700444
SP1 GATA3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15486968
ARHGEF2 PAK4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8397873 22653441
ARHGEF2 NFKBIE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
MOB1A LATS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21084559 19739119
MOB1B LATS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21084559 19739119
PPP6R2 PPP6C â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8208117 16769727
PPP6R1 PPP6C â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8208117 16769727
PPP6C NFKBIE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSPA8 NFKBIE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
ESR1 HSPA8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11085516
PPP6R2 NFKBIE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
PPP6R1 NFKBIE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
ANKRD28 NFKBIE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
PPP6R3 NFKBIE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
NFKBIE PPP6R1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8208117 16769727
KMT2C NCOA6 â—¼   PHYSICAL_INTERACTION 807.0 0.8 STRING 36370105
ESR1 BRCA1 â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 1204073 5215931 11244506
BRCA1 ASH2L â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22990118 26831064
BRCA1 TINF2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34112789 29656893
ESR1 AURKA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21761334 31527615
PLK1 BRCA1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 25483079 24067368 31730000 29656893
LRRK2 PRKDC â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 19826009 31046837 17400507
MOB1B MOB1A â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 24366813 33961781
ANKRD28 ANKRD44 â—¼   PHYSICAL_INTERACTION 831.0 0.83 STRING 36370105
PRKDC BRCA1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 10608806 25223785
ESR1 ASH2L â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 21502505 16603732 31527615
ESR1 RBBP5 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 21502505 16603732 31527615
WDR5 KMT2D â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 24981860
ASH2L PAXIP1 â—¼   PHYSICAL_INTERACTION 856.0 0.85 STRING 36370105
AURKA BRCA1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 22110403 14990569 26831064
WDR5 PAXIP1 â—¼   PHYSICAL_INTERACTION ✅ 0.86 0.86 mint 24981860
WDR5 HDAC2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 28514442 27705803
ANKRD44 PPP6R1 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
SP1 BRCA1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 14710355 16713569 12706836 10720440 17766039
KDM6A NCOA6 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 17178841 17761849 19433796 24981860 19047629 29785026
NCOA6 PRKDC â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 10823961 12519782
HDAC1 WDR5 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 23752268 27705803 33961781 26186194 33022573 22689669
ESR1 SP1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 10681512 17656465 17312152 16651265 18765668 10446910 15084343 16439465 15637147 19652226 15705965 15987735 9611253 15557281 9328340
FZR1 PLK1 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
NCOA6 WDR5 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
TERF2IP TINF2 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
NCOA6 RBBP5 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
ESR1 HDAC1 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
ESR1 NCOA6 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
NCOA6 ASH2L â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 17178841 19433796 17925232 12482968 17500065 23870121 23508102 33961781 24981860 34079125 19047629
GATA3 HDAC2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 29453984 26028330 31409898
HDAC2 SP1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 17312152 18059533 16713569 15713621 17894944 12091390 16036112 12151407 21159880 12176973 20697349
LATS1 MOB1A â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16061636 16674920 33141042 19739119 20624913 24255178 31941533
MOB1B LATS1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 16674920 19739119 33961781 24255178 34079125 24366813 18328708
ESR1 GATA3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 26153859 23403292 25303530
PAXIP1 WDR5 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
ESR1 HSPA8 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
KDM6A ASH2L â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17178841 17761849 31076518 23508102 33961781 20305087 24981860 34079125 29785026 17825402
HDAC2 BRCA1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 21946536 10220405 16713569
HDAC1 BRCA1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 21102443 10220405 16713569
NCOA6 ESR1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10866662 16794079 10567404 10681503 11773444 26487511
NCOA6 WDR5 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 17021013 19433796 17925232 27705803 23870121 17500065 33961781 24981860 26186194 19047629
AURKA PLK1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 22939629 18615013 18773538
KDM6A RBBP5 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17178841 17761849 31076518 17500065 23508102 33961781 24981860 29785026 17825402
KDM6A WDR5 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 17178841 17761849 27705803 33961781 24981860 26186194 29785026 17825402
GATA3 HDAC1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 29453984 34026424 26028330 31409898
HSPA8 LRRK2 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
KDM6A NCOA6 â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
HDAC2 SP1 â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
ANKRD44 PPP6C â—¼   PHYSICAL_INTERACTION 891.0 0.89 STRING 36370105
ASH2L NCOA6 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
KDM6A KMT2C â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
ASH2L WDR5 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 31544921 17925232 16253997 20305087 21285357 15960975 21531708 15199122 17178841 25666610 16892064 15960974 18066051 23870121 23508102 21884981 32076268 33022573 22939629 16878130 31076518 27705803 19556245 17500065 19131338 33961781 24981860 16603732 26186194
ASH2L RBBP5 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 25416956 31544921 17925232 12482968 16253997 21124902 20305087 21516116 21285357 32296183 21220120 15199122 17178841 16892064 15960974 23870121 23508102 26886794 16878130 31076518 17500065 19556245 19131338 33961781 24981860 16603732 23414517 34079125
ESR1 BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19887647 1244506 11782371 15674350 29367421 27977889 17392432 16860316 10334989 16260778 11244506 16061635 12400015 17505062 20060929 25499220 16713569 31527615 11493692
SP1 CD74 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8955189 10567217 17511886
NCOA6 RBBP5 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 17178841 19433796 17925232 12482968 17500065 23870121 23508102 33961781 24981860 19047629
ESR1 HDAC1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 17312152 31527615 24051437 33731348 14722073 21182205 15557281 18451880 14506733 15140878
HDAC1 SP1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15647279 20072153 19062177 11909966 17894944 21636851 18003922 12176973 11896613 15557281 10409740 11517158 15713621 12665570 15722551 17906119 16478997 18850004 16121030 16883603 12091390 15155736 18948152 18059533 16713569 20385359 15528196 16734381 12200149 12847090
ESR1 AURKA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21761347 21761334 18497064
BRCA1 ESR1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
KDM6A WDR5 â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
ESR1 SP1 â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
WDR5 NCOA6 â—¼   PHYSICAL_INTERACTION ✅ 0.91 0.91 mint 24981860
KMT2D RBBP5 â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
ASH2L KDM6A â—¼   PHYSICAL_INTERACTION 916.0 0.91 STRING 36370105
KDM6A KMT2D â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
KDM6A PAXIP1 â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
ASH2L KMT2D â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
HDAC1 SP1 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
HDAC2 HDAC1 â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 26949739
PPP6C PPP6R2 â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
PPP6C PPP6R3 â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
PPP6C PPP6R1 â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
HDAC2 HDAC1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 25241761 9520398 11287668 19703393 30737378 17894944 10444591 11466315 11777905 21258344 15297431 17956988 11102443 9885572 12032298 19041848 26496610 22416134 12493763 11739383 10581039 11804585 11564889 21670149 22939629 9150135 11919195 23752268 18059533 16713569 9804427 20388487 9790534 26949739 24981860 33961781 15987735 19182791 15451426 12920132 26344197
ASH2L KMT2C â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
KMT2C RBBP5 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
LATS1 MOB1A â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
LATS1 MOB1B â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
KMT2C WDR5 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
KDM6A RBBP5 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
RBBP5 WDR5 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 28514442 31544921 17925232 16253997 20305087 15960975 30089852 21531708 21220120 15199122 17178841 25666610 31685992 15960974 27320920 23508102 21884981 32076268 33022573 16878130 28813667 17041588 31076518 17500065 19556245 27705803 24981860 33961781 16603732 26186194 31400120
IGBP1 PPP6C â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
KMT2D WDR5 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
RBBP5 WDR5 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
ASH2L RBBP5 â—¼   PHYSICAL_INTERACTION 4.0 1.0 ACSN 11302744 12874027 17168535 19407509
ASH2L WDR5 â—¼   PHYSICAL_INTERACTION 4.0 1.0 ACSN 11302744 12874027 17168535 19407509
ASH2L WDR5 â—¼   SHARES_COMPLEX 4.0 1.0 ACSN 11302744 12874027 17168535 19407509
ASH2L RBBP5 â—¼   SHARES_COMPLEX 4.0 1.0 ACSN 11302744 12874027 17168535 19407509
BRCA1 AURKA â—¼   PHYSICAL_INTERACTION 8.0 1.0 ACSN 11877377 15459660 19075565 19793801 20011137 20029420 21060331 21337561
BRCA1 AURKA â—¼   PROTEIN_INTERACTION 8.0 1.0 ACSN 11877377 15459660 19075565 19793801 20011137 20029420 21060331 21337561
BRCA1 AURKA â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 11877377 15459660 19075565 19793801 20011137 20029420 21060331 21337561
SP1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15252835 17373631 18377656 19466541
AURKA BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 22864622 22340593 18026198 24775809 14990569
BRCA1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 11244506 12400015 15674350 10334989 16713569 11493692
CD74 AP2B1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 8397411 10480952 9202021 15749704
AURKA PLK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 63.0 1.0 Omnipath 18566290 23618492 27721411 24338364 15713655 28126323 34260926 19364923 33805672 33771996 32284347 27504491 33898950 10980711 26206521 21474997 32060423 27662907 28994651 33963314 18615013 23695676 34197606 18669648 25925375 26114094 19228686 28591578 22281053 18691976 20603326 15611664 27068477 27908669 26919439 26012549 18477460 34140642 25660017 27899378 19369195 21454580 25871386 24349352 12207013 20869364 11854496 20633640 28351953 24667170 25042804
WDR5 RBBP5 â—¼   PHYSICAL_INTERACTION 4.0 1.0 ACSN 11302744 12874027 17168535 19407509
WDR5 RBBP5 â—¼   SHARES_COMPLEX 4.0 1.0 ACSN 11302744 12874027 17168535 19407509
HDAC1 HDAC2 â—¼   PHYSICAL_INTERACTION 28.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21685935 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC1 HDAC2 â—¼   SHARES_COMPLEX 28.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21685935 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC1 HDAC2 â—¼   UP_REGULATES ✅ + 28.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21685935 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 21655924 23242655 18316616 20101232
SP1 TINF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21731707 9399940
SP1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 12237165 19351845 11345900 21235772 23209644 12429135 18006846 10982795 22622808 15691879 21191649
GSK3B ZNF281 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 29179460
GSK3B ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 10428798 10949034 17609434 15461668 9528769 12118371 15059947 16076840 17570479 7491495 12093745 8308015 15212693 15528270 7838153
GATA3 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17616709 20130088 20068169
KMT2D ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17145710 16603732
ESR1 GATA3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 26153859 25303530 10096242