Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
CASP3 CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17899380
FOXM1 PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23635401 18345025
FOXM1 PLAU â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20154714 19813088
FOXM1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16809346 17875680
FOXM1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16809346
HIF1A LRP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19828020 21454812
F2R MAPK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16580177 9924018
NFATC1 MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19661463 17239241
ESR1 MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23250869 22430216
MAPK1 MAP2K1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 23241949 8412360
MAPK1 DUSP7 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 intact 8209350 9788880
MAPK1 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15263086 15466214
ESR1 MAPK12 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16885352 22399296
DUSP7 MAPK14 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 intact 8209350 9788880
MAPK11 MAPK14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23602568 21900206
DUSP7 MAPK14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20626350 9788880
F2R MAPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16580177 9924018
MAPK3 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15263086 15466214
MAPKAPK2 MAPK11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8622669 7535770
ALOX5 MAPKAPK2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 11844797 10779545
NFATC2 NFATC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19564342 11786533
NFATC4 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16219765 17194453
ITGB3 PTPN11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6731544 12791772
SGK1 CREB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15733869 5217559
SP3 SGK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9415398 10614661
CREB1 SGK1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 15733869 5217559
VPS33A A2M â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HIF1A IL10 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17504662 15723200
SP3 IL10 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19564345 10861063
NFATC1 IL10 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18962896 21398617
SP3 IL10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20154735
CREB1 IL10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21084670
F7 F10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 29880919 11560488
F10 F2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 25769543 35114109
FGG ITGB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10438935 16239428
FGB ITGB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10438935 16239428
FGA ITGB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10438935 16239428
EPOR CRKL â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11443118 11124936
EPO CRKL â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11443118 11124936
JAK2 CRKL â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11443118 11124936
CFB C3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 809512 279011
C3 CD55 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 6238120 8786315
CFD C3 â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 809512 279011
C3 CPB2 â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 11939578 4098172
ITGB3 ITGAV â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5214491 11546839
ITGAV PECAM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8838667 7542249
F2RL2 CRK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
DOCK1 CRK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
F2 PLAU â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10996659 8428004
PLAU PLAT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7721771 16189514
JAK2 CAMK2A â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
JAK2 CAMK2G â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
JAK2 CAMK2B â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
JAK2 CAMK2D â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
TGFB1 VTN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11796824 16189514
FGA BCAR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16581250 8649368
VPS11 BCAR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
FGG BCAR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16581250 8649368
FGB BCAR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16581250 8649368
PTK2 BCAR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5221628 9285683
VWF BCAR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16581250 8649368
ITGB3 BCAR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16581250 8649368
BCAR1 DOCK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12615911
PPARG NCOR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17011499 8970730
MAZ PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17902047 19061500
ESR1 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16144913
PPARG CX3CR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19850645 16908772
PPARG NFATC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19953004 14573767
PPARG CPT1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15356291
ESR1 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 16144913
NR1H2 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 15722453
PPARG NR1H2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 15722453
PPARG CD36 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20592862
PPARG NR1H3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 15722453
PPARG PTGS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18309368
HIF1A ABCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15922656 19828131
HIF1A ITGB3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19828020 23640055
HIF1A BSG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19828020 22678117
VTN SERPINE1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216470 12808446
ESR1 SERPINE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15217907
SERPINE1 PLG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11113116 16713569
PLG PLAT â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 2318848 7199524
PLG PLAT â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 2496749 2962641
PLG PLAUR â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 3023326 2935528
PLAT PLG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11928826 1447176
SERPINB2 PLAUR â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 3090045 2166055
NFATC1 PLAUR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23015147
ESR1 PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19797124 20819530
PLA2G6 PTGS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17138645
CREB1 PTGS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21084670
CEBPB FURIN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8132667
FURIN VWF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8218226 1571548
GULP1 ITGB3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12606711 5216162
CREB1 ODC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1356108
CREB1 BDKRB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10842322
MAPK11 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11532940 11335727
CEBPB CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12773552
CEBPB F8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10959692
CEBPB CPT1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20627112 21586575
PROS1 MERTK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 12447359 25695599
PROS1 F8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16189514 7620160
GAS6 MERTK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 19631584 25695599
VWF PTK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11476890 16919435
FGA PTK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11476890 16919435
FGB PTK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11476890 16919435
FGG PTK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11476890 16919435
DUSP16 MAPK11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11359773
RXRA CPT1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15356291
PECAM1 CAMK2A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CAMK2A RAB5A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ARNT ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17991765
HNF1A ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 11522780
ESR1 SLC2A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14605097
PECAM1 VPS11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CFB CFH â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 1067618 301546
PPARD NR1H3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 15722453
NR1H3 PPARD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 15722453
PPARD NR1H2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 15722453
NR1H2 ABCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 25838426 20951680
NR1H2 PPARD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 15722453
SP3 AXL â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18522535 20977427
NFATC1 F2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19460777 19351910
HNF4A SERPINA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9927755 10330009
HNF4A F12 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19786295 9794469
HNF4A F2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12911579
ABCA1 RXRA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18782758 21507939
CAMK2D CAMK2B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20668654 1000426
FGA ITGAX â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10543983 17339034
F8 F2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0801735105 18492805
SP3 F2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12911579
F2 PROC â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 468991 2538457
F2 PROCR â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 468991 2538457
SERPINA5 F2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12878585 18362344
FGB ITGAX â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10543983 17339034
F9 F3 â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 2040636 2248955
F9 F7 â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 2040636 2248955
SERPINC1 F9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 31030036 20080729
F7 F9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 29880919 2248955
F9 F7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 2248955 12524220
F9 GGCX â—¼   CARBOXYLATION ✅ 2.0 0.8 Reactome 3667614 2738071
VWF F8 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0801735105 18492805
CASP1 CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18667412
A2M KLKB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 2579948 6203908
F12 KLKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 28966616 3521732
MASP2 C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11907111 11527969
MASP2 C4A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17204478 22949645
C5 CPB2 â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 11939578 4098172
C6 C7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17900710 10696521
EPOR EPO â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29997244 20178071
SERPINA5 PLAT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 2551064 16189514
FGG ITGAX â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10543983 17339034
GGCX PROC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 28125048 1498334
CFD CFB â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 809512 279011
SP3 ODC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9115370 10374837
SP3 F2R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9494121
MEGF10 ABCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17205124
CFI C4BPB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 293746 702059
C4BPA CFI â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 293746 702059
CFI CR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 6214588 1386357
F2RL2 F2R â—¼   PROXIMITY 2.0 0.8 intact 17376866 0700763104
CX3CR1 CX3CL1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9024663 9390561
C4A CD46 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12055245 2481448
CFI CD46 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 6214588 1386357
CD55 C4A â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 6238120 8786315
CFI C4A â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 293746 702059
GGCX F7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8647260 31226734
MAPK14 MAPKAPK2 â—¼   PHOSPHORYLATION ✅ + 0.8 0.8 Signor 14499342
JAK2 PTPN11 â—¼   PHYSICAL_INTERACTION 801.0 0.8 STRING 36370105
C8B C8G â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
F2 FGB â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
F2 FGG â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
DUSP4 MAPK1 â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 16038800 8275974
PPARD NCOR1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 11903058 11867749 21775429 15001550
DUSP16 MAPK14 â—¼   PHYSICAL_INTERACTION 812.0 0.81 STRING 36370105
F10 SERPINC1 â—¼   PHYSICAL_INTERACTION 816.0 0.81 STRING 36370105
C8B C9 â—¼   PHYSICAL_INTERACTION 816.0 0.81 STRING 36370105
CRKL DOCK1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33961781 26496610
MBL2 CR1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 23460739 29563915
C3 CFD â—¼   PHYSICAL_INTERACTION 819.0 0.82 STRING 36370105
BMP4 CALR â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
S1PR1 CD47 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
NCOR2 RXRA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 9415406 9878542 12665583 15604093 10082574
CR1 MASP1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 23460739 29563915
C1R C1QA â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 2372546 10878362
NR1H2 ABCA1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 23931754 25838426 20951680
CR2 CR1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 1708808 7690834
C3 CFHR4 â—¼   PHYSICAL_INTERACTION 834.0 0.83 STRING 36370105
C3 CR2 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
C3 ITGAM â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
F2 PROC â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
CFHR1 C3 â—¼   PHYSICAL_INTERACTION ✅ + 0.83 0.83 Signor 27814381
C1QC C1QB â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 21054788 16189514 12960167 28325905
ESR1 RXRA â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 9717844 23403292 9121466
NCOR2 NCOR1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 16033423 10944117 11013263
CEBPB ESR1 â—¼   PHYSICAL_INTERACTION 849.0 0.85 STRING 36370105
C8A C8B â—¼   PHYSICAL_INTERACTION 849.0 0.85 STRING 36370105
C8A C8G â—¼   PHYSICAL_INTERACTION 851.0 0.85 STRING 36370105
MBL2 CALR â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 18177377 8062452
NCOR1 NR1H2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 12663743 26120082 15604093
NCOR2 ESR1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 9702189 14715875 20392877 12738788 9171229 23403292
MASP1 MASP2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 23785123 10878362
NCOR1 PPARD â—¼   PHYSICAL_INTERACTION 862.0 0.86 STRING 36370105
F8 VWF â—¼   PHYSICAL_INTERACTION 864.0 0.86 STRING 36370105
PTK2 PTPN11 â—¼   PHYSICAL_INTERACTION 869.0 0.87 STRING 36370105
NCOR2 PPARD â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 11867749 15001550
CFH CFI â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
MAPK1 MAPK14 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
MASP2 MBL2 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
SERPINC1 F10 â—¼   CLEAVAGE ✅ - 0.87 0.87 Signor 31030036
MASP1 MBL2 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
CAMK2D CAMK2G â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
KLKB1 KNG1 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
NR1H3 NCOR1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 12663743 26120082 15604093 33961781
BCAR1 CRKL â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
MAPK1 MAPK3 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
PROC PROCR â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
BCAR1 CRKL â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 9498705 8810278 10753828 22974441 8978305 18835194
C1QB C1QA â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 14681455 21054788 12960167
VPS41 VPS11 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 33422265 26463206 33961781 26186194 28931724
ESR1 SP3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10816575 16651265 31527615
PPARD RXRA â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 22205725 34081964 19756148 15604093 15888456
KLKB1 KNG1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 291905 10464316 500690 17598838 7686159 7944388
F2 F5 â—¼   UP_REGULATES ✅ + 0.89 0.89 Signor 29880919
PTPN11 SIRPA â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
ITGB3 PTK2 â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
BCAR1 PTK2 â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
PPARG ATP2A2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22240811 18071073
PPARG LRP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12551936
MAPK1 MAP2K1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 10567369 19219045 8013650
MAPK1 MAP2K2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 10567369 19219045 8013650
MAPK1 DUSP5 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 Reactome 17208316 22569528 20463170
SGK1 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19447520
DUSP7 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9788880
MAPK1 ALOX5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12670876 12205041
MAPK1 SP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17685427
MAPK11 MAPK14 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
DUSP4 MAPK14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16849326 16189514 11387337
MAPK14 F3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 23195225
MAPK3 MAP2K2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 10567369 19219045 8013650
MAPK3 MAP2K1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 10567369 19219045 8013650
MAPK3 DUSP5 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 Reactome 17208316 22569528 20463170
MAPK3 DUSP7 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 Reactome 17208316 22569528 20463170
MAPK3 SP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17685427
MAPK3 ALOX5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12670876 12205041
MAPK3 SPHK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17311928
MAPK3 PTPN11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 8197172
NFATC2 IL10 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18962896 21398617 22427656
F10 F3 â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 3527261 3275472 6980899
GGCX F10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9538022 31226734
F8 F10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9759621 10521497 12426309
HIF1A ITGB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20517715 15235127
ITGB2 PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8649427 16189514
C1R C1QA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10904115 15388251 761607
C1QC C1QA â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 14681455 21054788 12960167 28325905
C1QA C2 â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 6019133 12396008 10925294
C1QA C4A â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 15199963 14280442 12396008
VTN C8G â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 2465906 7542572 2466593
MASP1 MBL2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11290788 32041782 20956340 27104295 10878362 21035894 19939495 22854970 18177377 25579818
MBL2 MASP2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11290788 32041782 27104295 10878362 15117939 18177377 29209066
C4A MBL2 â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 15199963 14280442 12396008
C2 MBL2 â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 6019133 12396008 10925294
ESR1 C3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10418989 8961270 17478088
C3 CFI â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 6607952 21788512 2971659
C1R C1QC â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10904115 15388251 761607
C1QC C1S â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10904115 15388251 761607
C1QC C2 â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 6019133 12396008 10925294
C1QC C4A â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 15199963 14280442 12396008
C1R C1QB â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10904115 15388251 761607
C1QB C1S â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10904115 15388251 761607
C1QB C4A â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 15199963 14280442 12396008
C1QB C2 â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 6019133 12396008 10925294
SP3 ITGAV â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10504395 12136940
VWF CRK â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16581250 10777559 12640026
FGB CRK â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16581250 10777559 12640026
ITGB3 CRK â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16581250 10777559 12640026
FGG CRK â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16581250 10777559 12640026
FGA CRK â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16581250 10777559 12640026
SERPINE1 PLAU â—¼   DOWN_REGULATES ✅ - 3.0 0.9 ACSN 11021826 20027185 25502501
PLG PLAU â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 2521625 2935528 1829461
PLAU PLG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 3920216 2829380 4226004
JAK2 PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10925297 9553131
NCOR1 PPARG â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11903058 17468099 10339548 30575522 15681609 15604093 19596656 22078880 35140242 11877444 16127449 30595551 23703729 21775429
NCOR1 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16713569 24051437 12145334 16469706 17400812 12738788 21182203
NCOR1 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 22395773 20462215
PPARG RXRA â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 22363753 16189514 12763030 10944516 31547433 30404011 20211142 35140242 25609649 17312272 23703729 7838715 19047629 12966085 22205725 14587029 10882139 30595551 30699358 9065481 21833030 9568716 34081964 21478865 9121466 23275339 17579352 19147680 26260846 16713569 12591919 10854698 30651555 32929351 23711995 11877444 15888456 18217139 19043829 17980149
PPARD PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20097210 10991946 20176998
NCOR2 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 22395773 21846906
HIF1A PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18461556 19490906 11879638
HIF1A SPHK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19828020 18055454
HIF1A SLC2A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15059920 7493931 9525945
SERPINE1 PLG â—¼   DOWN_REGULATES ✅ - 3.0 0.9 ACSN 11021826 20027185 25502501
C5 VTN â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 2465906 7542572 2466593
C9 VTN â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 2465906 7542572 2466593
VTN C8B â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 2465906 7542572 2466593
VTN C8A â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 2465906 7542572 2466593
VTN C7 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 2465906 7542572 2466593
VTN C6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 2465906 7542572 2466593
FGG VTN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16189514 2243140 11744726
VWF ITGB3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16040750 14754902 10446041
FGB ITGB3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16040750 14754902 10446041
CEBPB ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31527615 16651265 7651415 19652226 9817600
PROS1 MERTK â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 17442946 16737840 17064312
PROS1 PROC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16189514 1615482 2461936
MERTK GAS6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 17442946 16737840 17064312
PTK2 F13A1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CAMK2A PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15845548
C1S C1R â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 31749804 10092586 2387866 9477945 33961781 10878362 2372546 12788922 17996945
C1S C4A â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 15199963 14280442 12396008
C1R C2 â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 6019133 12396008 10925294
C1R C4A â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 15199963 14280442 12396008
NCOR2 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17591692 23015261 15802375
ESR1 CD24 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18404683
ESR1 F12 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9794469 11459781
RXRA ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 9841885 9717844
ESR1 RXRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 9841885 9717844
CFH CFI â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 26806831 9291131 1401896
RXRA NR1H3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 20682316 15722453 9013544 15604093 8621574 12117567
NR1H2 NR1H3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12470667 11875109 22194611
NR1H2 RXRA â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 15722453 20211142 7760852 15604093 24561505
CAMK2G NCOR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 22888005
RXRA HNF4A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10744771 11027556
HNF4A F2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12911579 24038112
HNF4A SERPINC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8910619 7758957
RXRA HNF1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11027556
RXRA PLAT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19538480
RXRA EPO â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15766748 21138976 11297512
C2 MASP1 â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 6019133 12396008 10925294
C4A MASP1 â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 15199963 14280442 12396008
MASP1 C2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11907111 10946292 11527969
F2RL2 F2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 873923 8615752 10079109
F2RL2 F2 â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 9618465 9087410 1672265
F2 F2RL3 â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 9618465 9087410 1672265
F2 F13A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9546612
F2 F8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18492805 10350471
F9 F11 â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 29223926 22961984 11342438
PROC F8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 1939075 1761551 16189514
MASP2 C2 â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 6019133 12396008 10925294
MASP2 C4A â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 15199963 14280442 12396008
C5 C6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 1387399 2808363
C8A C9 â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
C8A C9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10346902 3624872 4063341
EPOR EPO â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 9030560 29997244 9808045 17327410 9774108 26481148 15358619 10318834 8662939
SERPINA5 PROC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11123896 16189514
SP3 SLC2A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10556032 11689000 14644496
SP3 ABCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15922656 10884428
C4A CR1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10531307 11694537 293688
CFI CR1 â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 6607952 21788512 2971659
GAS6 AXL â—¼   PHYSICAL_INTERACTION ✅ + 0.9 0.9 Signor 16362042
SERPINC1 F9 â—¼   CLEAVAGE ✅ - 0.9 0.9 Signor 31030036
EPO EPOR â—¼   PHYSICAL_INTERACTION 904.0 0.9 STRING 36370105
C1QB C1QC â—¼   PHYSICAL_INTERACTION 907.0 0.9 STRING 36370105
MAPK1 MAPKAPK2 â—¼   PHYSICAL_INTERACTION 909.0 0.91 STRING 36370105
HNF4A HIF1A â—¼   PROTEIN_INTERACTION 0.91 0.91 HIPPIE 12097158 14741200
ELMO1 DOCK1 â—¼   PHYSICAL_INTERACTION ✅ 0.91 0.91 mint 12134158 5215575
NR1H2 RXRA â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
BCAR1 CRK â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
MAP2K2 MAPK3 â—¼   PHYSICAL_INTERACTION 924.0 0.92 STRING 36370105
C3 VSIG4 â—¼   PHYSICAL_INTERACTION 928.0 0.92 STRING 36370105
VPS33A VPS16 â—¼   PHYSICAL_INTERACTION ✅ 0.93 0.93 mint 29778605
PLAUR VTN â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
CFH CFHR1 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
F2 F2R â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
F9 SERPINC1 â—¼   PHYSICAL_INTERACTION 933.0 0.93 STRING 36370105
AXL GAS6 â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
PLAT SERPINE1 â—¼   PHYSICAL_INTERACTION 938.0 0.93 STRING 36370105
F2 SERPIND1 â—¼   PHYSICAL_INTERACTION 938.0 0.93 STRING 36370105
F2 SERPINA5 â—¼   PHYSICAL_INTERACTION 938.0 0.93 STRING 36370105
F2 SERPINC1 â—¼   PHYSICAL_INTERACTION 938.0 0.93 STRING 36370105
VPS16 VPS41 â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 28514442 26463206 26496610 33961781 26186194 22939629
ATP8A1 TMEM30A â—¼   PHYSICAL_INTERACTION 940.0 0.94 STRING 36370105
SERPINC1 F2 â—¼   CLEAVAGE ✅ - 0.94 0.94 Signor 31030036
C6 C8G â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
C6 C8B â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
C6 C9 â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
C6 C8A â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
C6 C7 â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
NCOR2 PPARG â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 23178929 17704298 15681609 15604093 19596656 35140242 11877444 30595551 17312272 23703729 16219912 19147680 20364085
DOCK1 ELMO1 â—¼   PHYSICAL_INTERACTION 949.0 0.95 STRING 36370105
F2 F2RL2 â—¼   PHYSICAL_INTERACTION 952.0 0.95 STRING 36370105
F2 F2RL3 â—¼   PHYSICAL_INTERACTION 952.0 0.95 STRING 36370105
C3 CR1 â—¼   PHYSICAL_INTERACTION 955.0 0.95 STRING 36370105
CAMK2A CAMK2B â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
NCOR2 RXRA â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
C5 C8G â—¼   PHYSICAL_INTERACTION 958.0 0.95 STRING 36370105
CRKL EPOR â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 11443118 9344843 9129019
JAK2 EPOR â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 14982882 12441334 11779507 8343951
DOCK1 ELMO1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 21930703 16495483 15723800 28514442 18768751 15247908 12134158 11595183 20732417 33961781 26186194 26882976 20016009
VPS18 VPS41 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 22939629 33422265 26496610 26463206 33961781 26186194 23901104 25783203 28931724
VPS16 VPS11 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 26463206 26496610 33961781 11382755 23901104
RAB5C RAB5A â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 17353931 26496610 33961781 34079125
C1QA C1QC â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
CAMK2B CAMK2D â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
F2 FGA â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
C5 C8A â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
C5 C9 â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
F2 THBD â—¼   PHYSICAL_INTERACTION 962.0 0.96 STRING 36370105
MAP2K1 MAPK3 â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
ITGAV TGFB1 â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
FGB FGG â—¼   PHYSICAL_INTERACTION 964.0 0.96 STRING 36370105
C1QA C1QB â—¼   PHYSICAL_INTERACTION 967.0 0.96 STRING 36370105
SERPINE1 VTN â—¼   PHYSICAL_INTERACTION 968.0 0.96 STRING 36370105
HIF1A ARNT â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 17916562 9159130 24434214 20049704 9704006 11606485 27684187 19168635 11829741 23458834 19845609 16861921 9079689 19251694 11593383 27320910 15850782 15833858 20562859 14764593 12391259 26496610 17197389 8663540 15479785 26160453 14668441 24056783 11025203 28205554 23796364 23363003 20458141 23086815 17213817 21620138 15615775 7836384 15319539 12393189 11782478 15347669 20932347 21512126 10085255 21435239 26350169 15031145 20603618 28628118 20699359 10671489 33961781 34592152 16520375 12810720 16954218 18024476
CAMK2A CAMK2D â—¼   PHYSICAL_INTERACTION 969.0 0.97 STRING 36370105
TGFBRAP1 VPS18 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
C1R C1S â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
C3 CFHR1 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
C5 C6 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
MAP2K1 MAPK1 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
C3 CD46 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
C5 C7 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
C3 CFI â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
EPOR JAK2 â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
PLAU SERPINE1 â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
ITGAX ITGB2 â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
C3 CFB â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
NCOR1 PPARG â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
NCOR2 PPARG â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
C5 C8B â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
F3 F7 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
TGFBRAP1 VPS16 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
C3 CFH â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
PPARG RXRA â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
MAP2K2 MAPK1 â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
VPS11 VPS33A â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
TGFBRAP1 VPS41 â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
VPS11 VPS16 â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
NR1H3 RXRA â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
FGA FGB â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
FGA FGG â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
DOCK1 CRK â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 31980649 17474147 10559471 17515907 11369773 15673687 8662907 33961781 12615911 8657152 26344197
CRK BCAR1 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 31980649 9581808 22974441 15673687 10208419 12615911 10464310 15492270 12799422 18835194 8631823 10747099 11278916 16413489 10753828 16267043 10329689 19380743 10085298 14657239 27669437 17038317 9920935 11369773 11839772
VPS11 VPS18 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 28514442 26496610 33961781 26186194 11382755 25783203 23901104 28931724
VPS16 VPS18 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 22939629 26496610 26463206 11382755 25783203 23901104
MAPK14 MAPKAPK2 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
VPS33A VPS41 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
VPS11 VPS18 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
VPS16 VPS18 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
VPS11 VPS41 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
PECAM1 PTPN11 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
VPS18 VPS33A â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
VPS16 VPS41 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
TGFBRAP1 VPS11 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
VPS18 VPS41 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
VPS16 VPS33A â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
CAMK2A ATP2A2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 7929371
MAPK14 CASP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 14970175 33176141 29414778
CASP3 PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 10224094 9463408
CASP3 BCAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 11511102 11447317 10712510
CASP3 NFATC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 16455648 17613518 19900451 9390557
HIF1A FOXM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22831955 19097132
FOXM1 PROC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15933209 7592627 8945631
CALR LRP1 â—¼   PHYSICAL_INTERACTION 9.0 1.0 ACSN 14508489 16181333 16239148 17204652 20958319 22076556 23157435 23850759 25351513
CALR LRP1 â—¼   PROTEIN_INTERACTION 9.0 1.0 ACSN 14508489 16181333 16239148 17204652 20958319 22076556 23157435 23850759 25351513
SERPINE2 LRP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 14596620
PLAU LRP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11560943
C3 LRP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10608878 1060887810608870
SERPINA1 LRP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 8626456 862645615131125 15131125
PLAT LRP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 25879083 10632583 1502153 11560943
SERPINC1 LRP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 8626456 14596620
SERPINE1 LRP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 1500157915001570 15001579 16713569
F9 LRP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11560943 1156094312522210 12522212
A2M LRP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 10652313 1702392 12194978 19026743
F8 LRP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12522143 1156094312522140 11560943
MAPK1 MAP2K2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11802164 15239952 21779496 11802165 15260967
MAP2K2 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 68.0 1.0 Omnipath 21675959 11704645 9694850 17081983 7565670 12750173 19690332 12932319 11823456 18799465 15592455 11337027 18083107 21365009 12788955 11134045 19219045 17389395 9447970 15342917 23331499 19534553 17569879 7559390 23047924 8226933 8223433 17272394 15851026 15811950 19494114 18988627 18669648 11549292 23519423 19541618 18691976 1381507 16293107 17906627 11986622 19933846 8376945 19053285 16094384 11971971 17192257 11136732 11948414 8388392 7898932 9731057 11730323 18039929 11118451 19369195 12920017 15951569 15466214 10746662
DUSP4 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23331499 8626452 15315965 32296183 18988627 7535768
DUSP5 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 23331499 10224087 19741200 15713638
MAPK14 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 15187187 21675959 18039929 12738796 11157753 22521293 17255949 11238443 11274345 12697810
MAP2K1 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 149.0 1.0 Omnipath 21675959 9694850 17081983 10757792 11319218 18799465 15592455 12788955 19415658 12697810 17389395 9447970 15342917 8226933 15851026 12270934 12644307 17255949 10998418 11242034 1378617 1381507 17906627 11986622 8376945 8157000 7992057 11948414 9731057 19651622 11251083 11266467 18707149 14743221 11279118 11704645 12750173 12932319 16497976 11337027 23331499 12048245 7559390 17272394 15811950 19494114 18669648 18691976 11741894 15972258 19053285 16094384 17192257 7898932 24623782 9166761 19369195 21336309 12920017 15466214 17016520 19901323 1712480 19690332 11823456 9032297 11134045 12876277 19534553 10995751 20068231 21506533 8223433 8248196 16153436 12594221 10567369 19933846 17563371 11730323 29175850 11352917 16135787 15951569 19058874 15212693 23241949 9560161 91184134 18083107 16887817 18578522 17569879 21071413 9148935 18452278 1330321 8670897 19541618 10777511 15935618 12925710 11971971 9765155 11136732 11118451 12082107 12952943 10746662 21768338
MAPK13 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12738796 18039929 11274345 15187187
DUSP2 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 8626452 16288922
MAPK1 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12975377 23602568 16424009 19058874 23397142 21707490
MAPK1 DUSP16 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 12794087 15689616 11359773 11489891
MAPK1 CEBPB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 16009338 12213825 8384717 10995751 12048245 15878863 21980398 19443782 17570479 19413330 19723873 15367685
MAPK1 SPHK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17311928
MAPK1 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 25409419 11733495 16574647 9099735 9030579 15507114 26670611 17570479 17998334 18596912
MAPK1 RXRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 10377179 17604322 12048211
MAPK1 NFATC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15657420
MAPK1 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 16954218 10551817 18519666 18687685 26784107
MAPK1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 15655247 10949034 15528270 18372406 15461668 12118371 12466266 7495695 17615152 15059947 16076840 7491495 12093745 10409727 9528769 7838153
MAPK1 MAPKAPK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 21675959 22028470 15094067 8846784 23047924 25255283 12861023 7592979 1327754 8995385
MAPK1 SPHK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16522638 14532121
MAPK12 MAPKAPK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12738796 18039929 11274345 15187187
ADAM17 MAPK14 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 24338472 12058067 10601018 20188673 12621058 10497257
DUSP8 MAPK14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 8910287 10915787 23159405 9922370
DUSP16 MAPK14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 12794087 20936779 26186194 11489891 14586399 11359773
DUSP2 MAPK14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 8626452 7535770
MAPK14 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 15187187 21675959 18039929 12738796 23397142 11238443 11274345 12697810
MAPK14 NFATC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 15649893 16648474 11997522 10747897 18347059 17255949 11274345 12697810
MAPK14 ADAM17 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12058067 20188673
MAPK14 MAP2K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15187187 18039929 12738796 11274345 12697810
MAPK14 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 23216744 22431515 12138194 15879307
MAPK14 MAPKAPK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 63.0 1.0 Omnipath 21675959 16456544 23602568 17395714 21988832 10581204 23331499 21071413 27898710 23047924 10922375 12738796 11551945 26496610 25852190 18988627 15629715 18669648 15187187 11042204 26186194 25241761 8846784 17906627 14499342 9922370 7923353 9768359 18039929 25255283 7592979 17255097 11274345 23455922
MAPK14 MAP2K2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12738796 18039929 11274345 15187187
MAPK14 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 11175347 12356771 15733869 11160957 11532940 7958915 9829964 12235136 16189514 11335727 9687510 8887554 11698596 23532963 8688081 9528766 11018520 11969286 11377386 11909979
MAPK14 NFATC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 15649893 20516082 16648474 12944472 11997522 10788511 15304486 10747897 17255949 10652349 11274345 12697810
MAPK14 NFATC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 15649893 20516082 16648474 15121840 12944472 10788511 11030334 10747897 17255949 11274345 12697810
MAPK3 MAP2K2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11802164 15239952 21779496 11802165 15260967
MAPK11 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12738796 18039929 11274345 15187187
MAP2K2 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 101.0 1.0 Omnipath 19901323 17081983 11704645 9694850 12750173 1411546 19690332 12932319 18799465 16497976 18083107 11134045 8626767 9006895 17389395 19219045 15342917 9447970 16887817 23331499 17569879 7867743 7559390 21071413 19534553 8226933 20068231 8223433 17272394 93330262 15851026 15811950 26987942 18988627 19494114 18669648 19541618 11242034 15466476 18691976 1381507 17906627 11986622 19933846 8376945 11971971 17192257 11136732 11948414 7898932 7687743 9731057 19651622 11730323 16464493 18983981 11251083 11118451 15580310 19369195 18707149 12920017 15951569 15466214 10746662 15212693
DUSP5 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 23331499 10224087 12944906 7836374 19741200
MAP2K1 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 106.0 1.0 Omnipath 9694850 17081983 11319218 18799465 17389395 9447970 15342917 8226933 15851026 12270934 12644307 11242034 1381507 17906627 9677429 11986622 8376945 7992057 11948414 7687743 9731057 19197339 11704645 7565670 12750173 12932319 8626767 23331499 12048245 7559390 17272394 15811950 26987942 19494114 18669648 18691976 17192257 8388392 7898932 16464493 19369195 12920017 15466214 19690332 11134045 19534553 10995751 7867743 8223433 8248196 10567369 19933846 17563371 1518847 11730323 18983981 16186792 16135787 15951569 19058874 15212693 10748187 9560161 9925641 9733512 18083107 11104681 9006895 17569879 21071413 7731720 1330321 93330262 19541618 15466476 12925710 11971971 11136732 11118451 10746662
MAPK13 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12738796 18039929 11274345 15187187
DUSP4 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 15315965 18988627 7535768
MAPK3 CEBPB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 16009338 12213825 8384717 10995751 12048245 15878863 19327116 19443782 15212693 15367685
MAPK3 SPHK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 16522638 21075214 15623571 14532121 16243846 19914200 18852266 19830907
MAPK3 NFATC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15657420
MAPK3 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10551817 18519666 24099156
MAPK3 ADAM17 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12058067 18187448 21570469
MAPK3 MAPKAPK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 21675959 17242355 7592979 14499342 14967450 23583303
MAPK3 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 10949034 18372406 15461668 9528769 12118371 14680484 17615152 15059947 16076840 7491495 12093745 15212693 15528270 7838153
MAPK3 NFATC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 10652349
MAPK3 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18596912 11733495
MAPK3 RXRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 10383391 12048211 10377179 15688020 18003614 27852823 17604322 11606411 20432439 16551633 12824162 15212693 17900311
MAPK3 MAZ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11809795
MAPK13 MAPKAPK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12738796 18039929 11274345 15187187
MAPKAPK2 ALOX5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 16165096 11844797 26210919 28257804 18978352 26173130 12205041 16005851 12670876 10779545
MAPKAPK2 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 11175347 17389598 10679065 12356771 15733869 8887554 9528766 11018520 11698596 11160957 11969286 12235136 7958915 9829964 9687510 20626350 11909979 8688081
NFATC2 PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23105117 18006811 21871017
NFATC1 NFATC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 19915002 18078995 15657420 18299389 16455648 11402342 11030334
NFATC4 PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16803872 21871017 16718377
PTPN11 IL10 â—¼   DOWN_REGULATES ✅ - 34.0 1.0 ACSN 10358138 11447289 11449354 11572860 12138178 12176909 1238444 12393695 12421919 12707331 12773515 12917349 15169881 15240681 15699106 15713798 16204085 19833085 20363967 20435894 21469115 22483603 22513334 22683124 22952938 22955274 25355530 26667266 26755705 27474009 8976179 8986721 9751747 9765283
JAK2 PTPN11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 8912646 23331499 21071413 7559603 8995399 9794795
PTPN11 PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 23335101 7589239 10082579 21726809 14572662 15561106 8986614 16189514 10655584 19698715 16920701 15598735
PTPN11 SIRPA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 8943344 18450421 18233962 8910355 12483539 9062191 18471880 11036942
SGK1 CREB1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 15733869 2052361 18088355 10826704 7608156
SGK1 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 11175347 12356771 15733869 8887554 9528766 11018520 11698596 11160957 11969286 12235136 7958915 9829964 9687510 18088355 11909979 8688081
CREB1 IL10 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11579131 15187187 15749884 16007092 16713974 17404308 20547845
IL10 ARG2 â—¼   ENZYMATIC_REACTION ✅ 31.0 1.0 ACSN 10433356 10542212 10623821 10925299 11207245 11438547 11875494 12193690 12811837 12818165 14607900 15282297 15579430 15749903 15833879 16200688 16424049 16713974 17404308 17485448 20184663 20435894 20547845 21115385 21191065 21220452 23124025 23508573 24378531 26755705 9834059
CEBPB IL10 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 24715531 17525287 12493739 12847250 16413748
CREB1 IL10 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 22140263 26408955 21986577 19564345 12493739 22116830 10540320 18263767 17202341
HNF4A F10 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11159521 8567696
F8 F10 â—¼   CLEAVAGE ✅ 7.0 1.0 Reactome 2105717 1958666 2303434 7803238 1346975 26023895 3965513
F9 F10 â—¼   CLEAVAGE ✅ 7.0 1.0 Reactome 2105717 1958666 2303434 7803238 1346975 26023895 3965513
F10 GGCX â—¼   CARBOXYLATION ✅ 4.0 1.0 Reactome 10917896 10068650 11513608 8530480
HIF1A ITGB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 7539918 15235127 1823643 16716598 12829734 9159130 13130303 9746763 12080085 11566883 10403805 8943284 15451019 9278421 16887934
FGA ITGB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 4062888
C3 ITGB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 4062888 26293614
ARNT ITGB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 7539918 15235127 1823643 16716598 12829734 9159130 13130303 9746763 12080085 11566883 10403805 8943284 15451019 9278421 16887934
CRK CRKL â—¼   PHYSICAL_INTERACTION 84.0 1.0 ACSN 10022831 10086337 10426994 10567412 10811803 10849428 10982827 11062502 11166270 11335727 11353765 11385609 11447289 11449354 11526404 11532940 11579131 11687500 11777939 11907067 11960372 12175651 12393695 12629515 12640133 12670391 13678960 15099563 15111329 15169881 15308668 15501236 15520864 15536084 15567848 15573129 15574420 16000375 16002046 16076871 16530705 16572188 16582911 16713974 16887996 17086423 17397400 17496910 17673906 17883421 18250477 18287025 18835194 19109239 19414323 19449109 19454690 19909365 20189481 20805416 21149606 21372296 21826665 22064427 22461508 22464172 23087689 23390297 23523669 24217602 24346288 24751819 24795729 25922287 25960930 26201938 26552706 7682895 8551221 8837607 9157999 9314552 9570538 9753319
CRKL BCAR1 â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 10426994 11062502 11353765 11385609 11447289 11526404 11579131 11687500 11907067 12670391 15169881 15308668 15536084 16000375 16076871 16713974 17397400 18250477 18287025 18835194 19109239 19454690 19909365 20189481 20805416 21149606 21826665 22464172 23087689 23523669 24751819 24795729 25960930 7682895 9314552
CRK CRKL â—¼   SHARES_COMPLEX 84.0 1.0 ACSN 10022831 10086337 10426994 10567412 10811803 10849428 10982827 11062502 11166270 11335727 11353765 11385609 11447289 11449354 11526404 11532940 11579131 11687500 11777939 11907067 11960372 12175651 12393695 12629515 12640133 12670391 13678960 15099563 15111329 15169881 15308668 15501236 15520864 15536084 15567848 15573129 15574420 16000375 16002046 16076871 16530705 16572188 16582911 16713974 16887996 17086423 17397400 17496910 17673906 17883421 18250477 18287025 18835194 19109239 19414323 19449109 19454690 19909365 20189481 20805416 21149606 21372296 21826665 22064427 22461508 22464172 23087689 23390297 23523669 24217602 24346288 24751819 24795729 25922287 25960930 26201938 26552706 7682895 8551221 8837607 9157999 9314552 9570538 9753319
CRKL BCAR1 â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 10426994 11062502 11353765 11385609 11447289 11526404 11579131 11687500 11907067 12670391 15169881 15308668 15536084 16000375 16076871 16713974 17397400 18250477 18287025 18835194 19109239 19454690 19909365 20189481 20805416 21149606 21826665 22464172 23087689 23523669 24751819 24795729 25960930 7682895 9314552
CRK CRKL â—¼   ENZYMATIC_REACTION ✅ 84.0 1.0 ACSN 10022831 10086337 10426994 10567412 10811803 10849428 10982827 11062502 11166270 11335727 11353765 11385609 11447289 11449354 11526404 11532940 11579131 11687500 11777939 11907067 11960372 12175651 12393695 12629515 12640133 12670391 13678960 15099563 15111329 15169881 15308668 15501236 15520864 15536084 15567848 15573129 15574420 16000375 16002046 16076871 16530705 16572188 16582911 16713974 16887996 17086423 17397400 17496910 17673906 17883421 18250477 18287025 18835194 19109239 19414323 19449109 19454690 19909365 20189481 20805416 21149606 21372296 21826665 22064427 22461508 22464172 23087689 23390297 23523669 24217602 24346288 24751819 24795729 25922287 25960930 26201938 26552706 7682895 8551221 8837607 9157999 9314552 9570538 9753319
CRKL BCAR1 â—¼   ENZYMATIC_REACTION ✅ 35.0 1.0 ACSN 10426994 11062502 11353765 11385609 11447289 11526404 11579131 11687500 11907067 12670391 15169881 15308668 15536084 16000375 16076871 16713974 17397400 18250477 18287025 18835194 19109239 19454690 19909365 20189481 20805416 21149606 21826665 22464172 23087689 23523669 24751819 24795729 25960930 7682895 9314552
BCAR1 CRKL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 8978305 9498705 18835194 10592173 8810278 10753828 12345678 8943292 23770091
CRKL BCAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 8978305 9498705 18835194 10592173 8810278 10753828 12345678 8943292 23770091
C9 C8G â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9038722 16999828 7691959 17505110 16079145
C8G CD59 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9038722 16999828 7691959 17505110 16079145
ITGAV ITGB5 â—¼   PHYSICAL_INTERACTION 9.0 1.0 ACSN 10837075 11146654 14697347 15031725 18353785 22035837 22470492 9295024 9763615
ITGAV ITGB5 â—¼   SHARES_COMPLEX 9.0 1.0 ACSN 10837075 11146654 14697347 15031725 18353785 22035837 22470492 9295024 9763615
PLAUR ITGB5 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 11306493 18633355 19833085 21840487 22470492 22595692 27216177 7512720 7521688
PLAU ITGB5 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 11306493 18633355 19833085 21840487 22470492 22595692 27216177 7512720 7521688
ITGB5 BCAR1 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 10837075 11146654 14697347 15031725 18353785 22035837 22470492 9295024 9763615
ITGB5 DOCK1 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 10837075 11146654 14697347 15031725 18353785 22035837 22470492 9295024 9763615
ITGB5 PTK2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 22470492 24309651 26519775 9295024 9763615
ITGB5 CRK â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 10837075 11146654 14697347 15031725 18353785 22035837 22470492 9295024 9763615
ADAM9 ITGB5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11162558
ITGB5 PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22824793 10592173 15673687 11927607
MBL2 MASP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 22607836 9087411 20956340 22854970 10878362 21035894 25579818 27104295 19939495 32041782
MBL2 MASP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11290788 9087411 15117939 10878362 27104295 22607836
CEBPB C3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 25617152 22171262 21308746 18247123 10594926
CFI C3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 16023208 1401896 26806831 9291131 8648130 2141838
CFH C3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 16023208 19050261 11367533 21979047 21317894 9988761 16612335
C3 C3AR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 8702752 11342658 8765043 20527893 9476119
C3 CR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 10382758 2551147 9988761 2141838
C3 ITGAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 4062888 16857732 7512600 7679388 12554829
C3 ITGAM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 4062888 11073102 26293614
VTN ITGAV â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 7525578 7559467 17968485 9251239 7685013 9443892
ITGAV ITGB3 â—¼   PHYSICAL_INTERACTION 23.0 1.0 ACSN 10022831 10545505 10837075 11146654 11335727 11532940 11553709 12000961 14697347 15031725 16919435 18353785 19161977 19339212 19449109 22035837 7512751 7529872 7657702 8636223 8755653 9295024 9763615
ITGAV ITGB3 â—¼   SHARES_COMPLEX 23.0 1.0 ACSN 10022831 10545505 10837075 11146654 11335727 11532940 11553709 12000961 14697347 15031725 16919435 18353785 19161977 19339212 19449109 22035837 7512751 7529872 7657702 8636223 8755653 9295024 9763615
ITGAV CRK â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 10837075 11146654 14697347 15031725 18353785 22035837 22470492 9295024 9763615
ITGAV BCAR1 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 10837075 11146654 14697347 15031725 18353785 22035837 22470492 9295024 9763615
ITGAV DOCK1 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 10837075 11146654 14697347 15031725 18353785 22035837 22470492 9295024 9763615
ADAM9 ITGAV â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15361064 11162558
VTN ITGAV â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23154389
ITGAV PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 19889638 12844492 23397142 10545505 7657702 8636223 10022831 19339212 11927607 19161977 16919435 7529872 11553709 8755653 7512751
CRK DOCK1 â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 11146654 12094222 12432077 14697347 15308668 16000375 16076871 18835194 22464172 9808620
CRK BCAR1 â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 11146654 11353765 12094222 12432077 14697347 15169881 15308668 16000375 16076871 18835194 19454690 20189481 22464172 9808620
CRK DOCK1 â—¼   SHARES_COMPLEX 10.0 1.0 ACSN 11146654 12094222 12432077 14697347 15308668 16000375 16076871 18835194 22464172 9808620
CRK BCAR1 â—¼   SHARES_COMPLEX 14.0 1.0 ACSN 11146654 11353765 12094222 12432077 14697347 15169881 15308668 16000375 16076871 18835194 19454690 20189481 22464172 9808620
BCAR1 CRK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 9920935 11369773 11278916 15673687 8662907 9581808 8631823 8070403 10747099 12065577 10329689 16267043 10592173 10208419 17038317 18835194 20627867 16413489 10753828 8943292 9860979 11839772 14657239 12799422 19380743 15492270 10085298 12615911
CRK DOCK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 9591773 35044719 17515907 10559471 11369773 9808620 10592173 15673687 12615911 8662907 17474147 8657152
CRK PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 7561682 25814554 12370821 20068231 11602246 10085298 12615911 7509446 7529876 17016520 11314030
PLAU PLAUR â—¼   PHYSICAL_INTERACTION 9.0 1.0 ACSN 11306493 18633355 19833085 21840487 22470492 22595692 27216177 7512720 7521688
PLAU PLAUR â—¼   SHARES_COMPLEX 9.0 1.0 ACSN 11306493 18633355 19833085 21840487 22470492 22595692 27216177 7512720 7521688
PLAU PLG â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 18633355 20027185 22470492 27216177
PLAU PTK2 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 11306493 18633355 19833085 21840487 22470492 22595692 27216177 7512720 7521688
SERPINE1 PLAU â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 22449964 2544876 2161846 21199867 3090045 9184208
SERPINA5 PLAU â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 9365930 2752144 16189514
SERPINB2 PLAU â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 2161846 2166055 8388810 16189514
PLAU PLAUR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 3031025 16879932 3023326 11501527 18376415 16189514 19017363 16456079
JAK2 EPO â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 9334184 9974393 9774108 9573010 11231127 2163696
JAK2 EPOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 10660611 12441334 7559499 8343951 18672044 11779507 12027890 11443118 12524467 9030561 9573010 15212693 10579919
FURIN TGFB1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 14557817 16474430 17934056 20519943 21900405
PPARG TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 14702344 17625041 31023188 17995524 16321227 18615188 14693716 12711314 16611854 18991162
RXRA TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18615188 8264664 16611854 18007025
HIF1A TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16896927 17053163 15611046 19211927 21209004 21057546 21055290
TGFB1 FURIN â—¼   CLEAVAGE ✅ 4.0 1.0 Reactome 11141505 11390472 12482908 7737999
FURIN TGFB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16474430 17934056 20519943 21900405 14557817
BCAR1 DOCK1 â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 11146654 12094222 12432077 14697347 15308668 16000375 16076871 18835194 22464172 9808620
BCAR1 DOCK1 â—¼   SHARES_COMPLEX 10.0 1.0 ACSN 11146654 12094222 12432077 14697347 15308668 16000375 16076871 18835194 22464172 9808620
PTK2 BCAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 48.0 1.0 Omnipath 8649427 7479864 12135674 15673687 8810278 9038154 8670206 9285683 11604500 11119718 12480533 24939893 8621540 11577104 9360968 9148935 10592173 12119061 12972425 9360983 10092764 21855630 10753828 11839772 18233957 10545505 12615911 8662921 11514617
ADAM10 ADAM17 â—¼   PHYSICAL_INTERACTION 5.0 1.0 ACSN 18676862 19601831 19704010 19726682 22006996
ADAM10 ADAM17 â—¼   PROTEIN_INTERACTION 5.0 1.0 ACSN 18676862 19601831 19704010 19726682 22006996
HIF1A ADAM10 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 10804084 16110315 16127144 17533374 20427344 20535745 20855962 21051947 21765015 22006996 22850421 22988108 24006507 25043024 25103413 25732824
PPARG NCOR1 â—¼   PHYSICAL_INTERACTION 11.0 1.0 ACSN 11399519 11875494 15644117 16127449 17260466 17681149 17689680 21234400 23390297 6357187 8871614
NCOR1 NCOR2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 ACSN 15465827 16127449 21234400 22796940
PPARG NCOR1 â—¼   SHARES_COMPLEX 11.0 1.0 ACSN 11399519 11875494 15644117 16127449 17260466 17681149 17689680 21234400 23390297 6357187 8871614
NCOR1 NCOR2 â—¼   SHARES_COMPLEX 4.0 1.0 ACSN 15465827 16127449 21234400 22796940
NCOR1 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 15175761 11877444 15604093 16127449 11903058 22078880 23703729 9121466 21775429 17468099
NCOR1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 16469706 12738788 12145334 17400812 16713569 21182203
PPARG CD36 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 10432118 10485906 12223527 12244147 14610620 15634881 17681149 23124025 24204259
CEBPB PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 22473998 23934183 7557387 12524424 16431920 22610404 15110775 18694725 17242167 16054042 15158467 9950217 10862621 20829347
PPARG PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 11278336 16506021 19578162 20234816 10827178 14555539 11412039 19997048 20656057
PPARG SERPINE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 10329404 15990085 18278065 14581151 17906687 17995524 10073956 16843437 11230363
PPARG CD36 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 17322100 18072748 16959872 18948972 20950277 18242221 11795270 10432118 14752028 15104237 25721714 11867619 16556603 11595817 16407258
PPARG ABCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 16530456 22424975 17026988 12595494 18511057 11742860 22305277 11785957 18758514 18761326 11172721 20951680 22429094 20419060
PPARG NR1H3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11604492 16959872 24751522 14703507
RXRA PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 56.0 1.0 Omnipath 12763030 25609649 20211142 11877444 16504037 17579352 16713569 9065481 22205725 23331499 22363753 10854698 19147680 19043829 12591919 9568716 10882139 10935544 17980149 26260846 21478865 14587029 23711995 9121466 18217139 31547433 7838715 19047629 23275339 21833030 12966085 17312272 11237216 15888456
NCOR2 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 15175761 16219912 20364085 15604093 17704298 17312272 23703729 9121466 19147680
CALR SCARF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15371419
CD47 SIRPA â—¼   PHYSICAL_INTERACTION 5.0 1.0 ACSN 10657674 11509594 14568985 20150200015 22310103
CD47 SIRPA â—¼   PROTEIN_INTERACTION 5.0 1.0 ACSN 10657674 11509594 14568985 20150200015 22310103
ARNT HIF1A â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
HIF1A SLC2A1 â—¼   ENZYMATIC_REACTION ✅ 66.0 1.0 ACSN 10102273 10428030 10428780 10435632 10804084 10823814 11557773 11559532 11744734 11756417 11884613 12402042 12676992 12743597 14672622 14684737 14699081 14762718 15024076 15059920 15199147 15240700 15312748 15369676 15379897 15545625 16110315 16126909 16127144 16517405 16517406 16585195 16782875 16888645 17143338 17418790 17533374 17785433 18054315 18056423 18158893 18718909 19211554 20028863 20427344 20535745 20855962 21051947 21765015 22006996 22841746 22850421 22988108 24006507 25043024 25103413 25732824 7493931 7500013 7508926 8089148 8702901 8955077 9486205 9525945 9707622
HIF1A ARG1 â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 10804084 10925299 12193690 16110315 16127144 17533374 20427344 20535745 20855962 21051947 21765015 22006996 22850421 22988108 23390297 24006507 25043024 25103413 25732824 6357187
HIF1A PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 19106818 16397226 21149600 14507857 16818642 23144021
HIF1A EPO â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 16189267 20404921 15838297 21212189 8089148 21054399 10559391 11001829 8756616 20043814 8660378 16684536 16281953 8260699 10207038 8900415 11914036 10477681 11707426 9235919 10202154 11812905 18423195 21309574 15347669 15315937 11971899 14741200 9236155 7836384 7852211 17712557 9654078 24023421 10837481 20631191 8663540 10415537
HIF1A PLAUR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16956360 17335808 19177204 17357815
HIF1A SLC2A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 19828020 17426252 18097583 15525582 17431122 16025159 17486380 15620252 23661628 18268343 11120745 17322369
HIF1A SERPINE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 19828020 10590062 11877282 17570486 18381294 9427542 14708599 17721610 15968405 16778202 17197388 19132225 20216986 21132271 14567996 14978738 20136501 17384280 12393531 19490965 8672239 11313255 20351105
ARNT HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 17213817 8816435 17197389 14764593 12393189 12810720 15319539 23363003 9079689 11829741 15479785 26496610 12391259 17916562 24434214 11606485 20562859 9704006 21620138 11782478 20932347 15347669 8927054 21435239 19168635 9159130 14668441 20049704 20603618
CREB1 SERPINE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18471910 20136501 17721610
VTN SERPINE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 11113116 12808446 11796824 8830783 16713569 9065424
SERPINE1 PLAT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 2110366 16713569 8607113 3090045
SERPINF2 PLG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 3334852 134998 158022 2437112
PLG F2R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10978167
PLAUR PTK2 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 11306493 18633355 19833085 21840487 22470492 22595692 27216177 7512720 7521688
SP3 PLAUR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17297470 17317820 20736951 16261846 9988707
VTN ITGB3 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 7525578 7559467 17968485 9251239 7685013 9443892
VTN ITGB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16195248 11331280
CREB1 PTGS2 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11579131 15187187 15749884 16007092 16713974 17404308 20547845
NFATC1 PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21515435 16909108 11423565 21871017 19748606
NFATC3 PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21642596 21871017 24291639
PPARD PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17178883 17693664 18566335 16966336 12901877
SP3 PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16840740 17616668 10825178 17012241
CREB1 PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 20954072 21668646 15213229 11092885 18515110 19925797 22919060 17559081 16007171 17505916 17186551 15221958 11668179 11526505 24378735 20032081 17524357 16256955 19797430 16319525 21268077 15289885 17632087 17962194 14645533
CEBPB PTGS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 7559624 11259631 18367585 11095928 14966110 12914528 15221958 18294142 11668179 17556653 10652293 21150337 20506344 18820298 18650268 16786175 10631313 10841183 22369775 19908286 16820889 11522796 15713664 16699180 16399783 10956548 11278846 10724331 16981245 18444174 14645533 16452236 12086405
FURIN ADAM17 â—¼   CLEAVAGE ✅ 5.0 1.0 Reactome 22246777 22246778 12755693 14623079 25795784
ITGB3 PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 9169439 8649427 10545505 7657702 8636223 10022831 19339212 11927607 11940607 19161977 10592173 16919435 7529872 11553709 8755653 7512751
CREB1 PLAT â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 7543410 8647095 11179965
CAMK2D CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 11175347 12356771 15733869 22554507 8887554 9528766 11018520 11698596 11160957 11969286 12235136 7958915 9829964 9687510 11909979 8688081
CAMK2G CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 11175347 12356771 15733869 8887554 9528766 11018520 11698596 11160957 11969286 12235136 7958915 9829964 9687510 11909979 8688081
CAMK2A CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 26.0 1.0 Omnipath 11175347 12356771 15733869 1646483 11160957 9668047 7958915 9829964 12235136 11970864 9687510 8887554 11698596 8688081 9528766 11018520 11969286 11013247 11909979
CAMK2B CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 11175347 12356771 15733869 8887554 9528766 11018520 11698596 11160957 11969286 12235136 7958915 9829964 9687510 11909979 8688081
ESR1 CEBPB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19652226 18414489
CEBPB ARG1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9013624 15922518 19805133 8612622 23913966
CEBPB A2M â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14661739 16431954 12223092 11481261
CAMK2A CEBPB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 1314426
PROS1 AXL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 7867073 29531161 78670737867073
PROS1 F5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 10593904 8428962
PROS1 GGCX â—¼   CARBOXYLATION ✅ 4.0 1.0 Reactome 10917896 10068650 11513608 8530480
GAS6 MERTK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 23331499 27801848 8939948 9160883
GAS6 AXL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 7867073 23331499 8621659 27801848 8939948 27829217 12218057 7854420 18988627 16362042
MAPK11 MAP2K2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12738796 18039929 11274345 15187187
CAMK2A NCOR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 22888005
CAMK2A ALOX5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11844797 18978352 10779545
RAB5A RAB14 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 16522682 16154996 14617813 23519112
ESR1 PBX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19376833 18414489
NCOR2 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 12738788 14715875 9171229 9702189 20392877
CFHR1 CFH â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 8663389 16189514 27814381 19528535
NR1H3 ABCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 45.0 1.0 Omnipath 12032171 19718435 17587765 15280160 12198243 21219878 11788472 11641412 15292368 16141411 14764426 22305277 23466610 24603323 22429094 15922656 22389325 15171719 21521932 15949682 19342446 22683903 23523156 17526932 18580406 16254209 16901265 18372238 11287605 17887732 20570635 15774904 16099444 10858438 11264984 19787078 17026988 22711909 23686490 16803904 16730733 19201410 17135302 19258656 20419060
RXRA NR1H3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 20682316 12117567 23331499 15722453 15604093 21071413 9013544 18988627 10890879 8621574
NR1H2 ABCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15831500 16141411 15292368 23523156 16644917 20951680 16825483 21507939 19258656
NR1H2 RXRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 15604093 21071413 24561505 9199332 7760852 16189514 18988627
HNF4A EPO â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9027736 14741200 21988864 9371982 9510530 7891708
HNF4A HNF1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 8367288 9111350 9792724 8674436 11717395 9313764 9837989 9204893 9232592 1734282 20850486 8735941 11145965 11085951 10331424 8808405 12601360 16670373
ARNT EPO â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 8089148 10207038 20631191 11782478 8663540 8408001
RXRA PPARD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 22205725 23331499 15604093 9933587 19756148 11237216 15888456
F2 FGA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 25241761 2133223 2742826 1587268
FGA PLAT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 3088041 11170397
FGA ITGAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 4062888 7679388
F8 F2 â—¼   CLEAVAGE ✅ 7.0 1.0 Reactome 19240027 8052958 2104766 15705787 1851341 2109644 1973901
F2 F11 â—¼   CLEAVAGE ✅ 4.0 1.0 Reactome 10781579 8338946 2019570 9888880
F2 VWF â—¼   CLEAVAGE ✅ 7.0 1.0 Reactome 19240027 8052958 2104766 15705787 1851341 2109644 1973901
GGCX F2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 3944102 10556651 31226734
SERPINC1 F2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 17145710 3800906 2013320 28743742 11927130 31030036 7238875
F2 THBD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 17145710 14691232 7615164 2544585 8663147
F2 F2R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 9058715 10978167 15707890 10644723 14652070 11356985 23450633 18250335 12563219 22972936
F2 F2RL3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 1273221212732210 12732212 22318735
F2 F2RL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 11356985 12732212 1135698512732210
F2 F5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10026263 9032460 29880919
F2 GGCX â—¼   CARBOXYLATION ✅ 4.0 1.0 Reactome 10917896 10068650 11513608 8530480
GGCX F9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11133752 31226734
VWF F8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 18492805 9218428 27749002 3134349 23020315
KNG1 KLKB1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 14996700 12123826 11830581 8344943
F12 KLKB1 â—¼   CLEAVAGE ✅ 4.0 1.0 Reactome 30394658 30591525 27130860 6604055
KLKB1 KNG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 3650269 500690 7944388 10464316 7686159 27006387 28966616 291905
HNF1A PROC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15933209 8945631 11140943 9553065 7881411
HNF1A SERPINA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 2844524 10330009 2020548 3263567 3262058
C5 CD59 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9038722 16999828 7691959 17505110 16079145
C5 C5AR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 35.0 1.0 Omnipath 9881961 11773063 9553099 15661745 10602324 1847994
C9 C8B â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9038722 16999828 7691959 17505110 16079145
C8B CD59 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9038722 16999828 7691959 17505110 16079145
C9 C6 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9038722 16999828 7691959 17505110 16079145
C6 CD59 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9038722 16999828 7691959 17505110 16079145
C9 C8A â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9038722 16999828 7691959 17505110 16079145
EPO EPOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 49.0 1.0 Omnipath 17145710 8662939 9442088 15358619 9030560 9974393 9774108 18586265 23331499 2163696 10318834 21889455 17327410 16982323 29997244 9808045
SP3 PLAT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10452548 21437359
F7 F3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 17145710 25241761 15664864 8940045 9414278 9925787 15522303 8598903 12787023
PROC PROCR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 7929370 11099506 10681521 16189514
PROC THBD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 12588872 11106601
PROC F5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 10026263 1615482 7989361 29880919
PROC GGCX â—¼   CARBOXYLATION ✅ 4.0 1.0 Reactome 10917896 10068650 11513608 8530480
KNG1 BDKRB2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 18127230 3366244 8063797 1314587
KNG1 BDKRB1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 18127230 3366244 8063797 1314587
F12 KNG1 â—¼   CLEAVAGE ✅ 8.0 1.0 Reactome 3886654 874082 11204562 6604055 11986212 1066663 14691562 7391081
KNG1 BDKRB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 9313952 8856107 8735629 9111052 8063797 10422787
KNG1 BDKRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 9203620 8063797 8302267 28966616
CX3CL1 CX3CR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 9390561 10488147 14607932 10699158 28389721 11432858 16189514 22633458 9931005
F12 F11 â—¼   CLEAVAGE ✅ 4.0 1.0 Reactome 1998667 588558 893417 10781579
C7 CD59 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9038722 16999828 7691959 17505110 16079145
CD59 C9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 7523406 1377690
C9 C7 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9038722 16999828 7691959 17505110 16079145
TIMD4 HAVCR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 28949386 15793576
F7 GGCX â—¼   CARBOXYLATION ✅ 4.0 1.0 Reactome 10917896 10068650 11513608 8530480