Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
Graph tools:

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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
SERPINE1 PLG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11113116 16713569
HSPA8 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
UBE2D2 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SMAD3 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
APP F12 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
EPAS1 MMP13 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20495570 23417678
ESR1 SERPINE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15217907
ESR1 HSPA8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11085516
HNF4A F12 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19786295 9794469
MMP13 F12 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10930399
MMP14 F12 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10930399
F12 KLKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 28966616 3521732
HNF4A SERPINA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9927755 10330009
APP F11 â—¼   PHYSICAL_INTERACTION 848.0 0.84 STRING 36370105
C1QBP F12 â—¼   PHYSICAL_INTERACTION 853.0 0.85 STRING 36370105
MMP14 C1QBP â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 11773076 12220632 16713569
GP1BA GP9 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
KLKB1 KNG1 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
C1QBP KNG1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 34804054 8710908
ESR1 HSPA8 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
SERPINE1 PLG â—¼   DOWN_REGULATES ✅ - 3.0 0.9 ACSN 11021826 20027185 25502501
ESR1 F12 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9794469 11459781
F12 SERPING1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 3756141 4703226 2578463
MMP12 F12 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10930399
HNF4A SERPINC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8910619 7758957
KLKB1 SERPING1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 3756141 2579948 4178758
HNF4A HIF1A â—¼   PHYSICAL_INTERACTION 0.91 0.91 HIPPIE 12097158 14741200
KLKB1 C1QBP â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 14996700 12123826 11830581 8344943
F12 C1QBP â—¼   CLEAVAGE ✅ 8.0 1.0 Reactome 3886654 874082 11204562 6604055 11986212 1066663 14691562 7391081
UBE2D3 EPAS1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
UBE2D2 EPAS1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
UBE2D1 EPAS1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
HIF1A EPAS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20513003 18174278 16924414 19030186
EPAS1 SERPINE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 20061373 16778202 17570486 20039838 15039136 17804822
ESR1 MMP13 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19185056 18358246 16919424
SMAD3 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11555647 23331499
F11 GP1BB â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 12391017 3017409 11696542 1730602
F11 GP1BA â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 12391017 3017409 11696542 1730602
F11 GP5 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 12391017 3017409 11696542 1730602
F12 F11 â—¼   CLEAVAGE ✅ 4.0 1.0 Reactome 1998667 588558 893417 10781579
F11 GP9 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 12391017 3017409 11696542 1730602
F12 GP1BB â—¼   CLEAVAGE ✅ 4.0 1.0 Reactome 1998667 588558 893417 10781579
F12 KNG1 â—¼   CLEAVAGE ✅ 8.0 1.0 Reactome 3886654 874082 11204562 6604055 11986212 1066663 14691562 7391081
F12 GP9 â—¼   CLEAVAGE ✅ 4.0 1.0 Reactome 1998667 588558 893417 10781579
F12 GP1BA â—¼   CLEAVAGE ✅ 4.0 1.0 Reactome 1998667 588558 893417 10781579
F12 KLKB1 â—¼   CLEAVAGE ✅ 4.0 1.0 Reactome 30394658 30591525 27130860 6604055
F12 GP5 â—¼   CLEAVAGE ✅ 4.0 1.0 Reactome 1998667 588558 893417 10781579
UBE2D2 HIF1A â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
UBE2D1 HIF1A â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
UBE2D3 HIF1A â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
HIF1A SERPINE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 19828020 10590062 11877282 17570486 18381294 9427542 14708599 17721610 15968405 16778202 17197388 19132225 20216986 21132271 14567996 14978738 20136501 17384280 12393531 19490965 8672239 11313255 20351105
KLKB1 KNG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 3650269 500690 7944388 10464316 7686159 27006387 28966616 291905
KNG1 KLKB1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 14996700 12123826 11830581 8344943
SMAD3 SERPINE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 19643931 15840021 19563779 12551947 24330518 9792626 19132220 19887897 11590145 9765209 19586629 18333754 16169848 15561701 10092624 10557285 20093492 11387330 9606191 17761371 23063463 15198928 9380693