Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
CD2AP CBL â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 11067845 5213160
CBL FGFR3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBL FGFR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBL FGFR4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
KPRP GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
GRB2 SHANK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
GRB2 PDLIM7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
MAPK1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8994038
FGFR1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9480847 16713569
FRS3 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15485655
NPM1 COL8A1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
TRIP6 HOXA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
PLSCR1 HOXA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
CATSPER1 TRIP6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
SHANK3 FRS3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
FRS3 KARS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
FGFR3 KRT33B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HRAS KRT33B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
GPRIN2 PLSCR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
SPRY2 GPRIN2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
FGFR3 SOCS6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HRAS MIIP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HRAS BLZF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HRAS ERBB2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
ERBB2 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 17673906
FGF19 FGFR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0907812106 19706524
KLB FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17623664 29648978
C22orf39 FGFR3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
FGFR3 MIIP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
FGFR3 SPATA12 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
FGFR3 BLZF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SPRY2 PLSCR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
KRAS ERBB2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
NRAS ERBB2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
ERBB2 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11173924 16713569
NTF4 BDNF â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29997244 20178071
NTF4 BDNF â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
FGFR4 FGF19 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0907812106 19706524
VASP PLSCR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
SHANK3 NOTCH2NLA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
SHANK3 LINGO1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
FRS3 KRTAP3-2 â—¼   PHYSICAL_INTERACTION 0.8 0.8 HuRI 32296183
C11orf1 CATSPER1 â—¼   PHYSICAL_INTERACTION 0.8 0.8 HuRI 32296183
KRT34 PLLP â—¼   PHYSICAL_INTERACTION 0.8 0.8 HuRI 32296183
HOXA1 WDR83 â—¼   PHYSICAL_INTERACTION 0.8 0.8 HuRI 32296183
AKAP8L KPRP â—¼   PHYSICAL_INTERACTION 0.8 0.8 HuRI 32296183
FGF19 KLB â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
KPRP KRTAP3-2 â—¼   PHYSICAL_INTERACTION 0.8 0.8 HuRI 32296183
ALK FRS3 â—¼   PHYSICAL_INTERACTION 804.0 0.8 STRING 36370105
DMRT3 KRTAP6-2 â—¼   PHYSICAL_INTERACTION 0.8 0.8 HuRI 32296183
FRS3 KRTAP3-1 â—¼   PHYSICAL_INTERACTION 0.8 0.8 HuRI 32296183
GRB14 HRAS â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
HOXA1 KRT33B â—¼   PHYSICAL_INTERACTION 0.81 0.81 HuRI 32296183
FRS3 ID2 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HuRI 32296183
FRS3 PLLP â—¼   PHYSICAL_INTERACTION 0.81 0.81 HuRI 32296183
ATP23 FRS3 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HuRI 32296183
FRS3 KATNBL1 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HuRI 32296183
CCN3 COL8A1 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HuRI 32296183
C11orf1 HOXA1 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HuRI 32296183
HOXA1 ID3 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HuRI 32296183
HOXA1 PLLP â—¼   PHYSICAL_INTERACTION 0.81 0.81 HuRI 32296183
KPRP KRTAP10-8 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HuRI 32296183
AKAP8L DMRT3 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HuRI 32296183
NTRK1 CBL â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 25921289 21570973
FGFR2 FGFR1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
NTRK2 NTF3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 8621424
FRS3 KRTAP11-1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HuRI 32296183
HOXA1 KRT34 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HuRI 32296183
KRTAP11-1 KRTAP6-2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HuRI 32296183
KRAS MAPK1 â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
FRS3 STK16 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HuRI 32296183
FRS3 ID3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HuRI 32296183
KRTAP6-2 TSPAN4 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HuRI 32296183
CATSPER1 TSPAN4 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HuRI 32296183
KRTAP10-8 KRTAP3-1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HuRI 32296183
ATP23 STK16 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HuRI 32296183
DMRT3 RFX6 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HuRI 32296183
SOS1 KRAS â—¼   GTPASE_REACTION ✅ + 0.82 0.82 Signor 25624485
KRTAP11-1 STK16 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HuRI 32296183
FGFR1 KLB â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
COPS3 GRB2 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
KRTAP10-8 TSPAN4 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HuRI 32296183
KPRP KRTAP6-2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HuRI 32296183
ERBB2 FGFR4 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 30898150 28628118 28205554
ALK GRB2 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
ATP23 HOXA1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HuRI 32296183
HOXA1 TSPAN4 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HuRI 32296183
FGFR1 KL â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
COL8A1 KRTAP6-2 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HuRI 32296183
KRAS NRAS â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
ID3 TCF4 â—¼   PHYSICAL_INTERACTION 848.0 0.84 STRING 36370105
CBL ERBB2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 26716506 12574167 25081058
ERBB2 GRB2 â—¼   RELOCALIZATION ✅ + 0.85 0.85 Signor 14967450
COL8A1 KPRP â—¼   PHYSICAL_INTERACTION 0.85 0.85 HuRI 32296183
COL8A1 KRTAP3-2 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HuRI 32296183
SPRY2 CBL â—¼   PHYSICAL_INTERACTION ✅ 0.86 0.86 mint 16893902 6169676
FGFR3 GRB2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 9045692 26344197
FRS3 RFX6 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HuRI 32296183
NTF3 BDNF â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 33961781 7703225
FGF23 KL â—¼   PHYSICAL_INTERACTION 860.0 0.86 STRING 36370105
CBL ERBB2 â—¼   PHYSICAL_INTERACTION 861.0 0.86 STRING 36370105
KRTAP10-8 KRTAP11-1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HuRI 32296183
CATSPER1 RFX6 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HuRI 32296183
FRS3 KRTAP6-2 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HuRI 32296183
MATK ERBB2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 9461599 12122014 16273093
FRS3 GPRIN2 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HuRI 32296183
HOXA1 KRTAP6-2 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HuRI 32296183
HOXA1 SPRY2 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HuRI 32296183
HRAS NRAS â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
CD2AP SH3KBP1 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
FRS3 KRT35 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HuRI 32296183
FGFR2 FGFR3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 23972473 33961781
FGF19 FGFR4 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 19706524 10525310
DMRT3 KRTAP3-1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HuRI 32296183
CBL CD2AP â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
GPRIN2 KRTAP10-8 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HuRI 32296183
DMRT3 KRT35 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HuRI 32296183
NTRK1 GRB2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11733534 25921289 10748052
FGFR2 GRB2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24440983 22726438
FRS3 KRT76 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HuRI 32296183
FGF23 FGFR1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 22393163 27879395 19966287 17086194
NTRK2 BDNF â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 21651720 11855816 9312147
GATA1 TRIP6 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 25910212 35140242 33961781 26186194
FRS3 HOXA1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HuRI 32296183
DMRT3 KPRP â—¼   PHYSICAL_INTERACTION 0.89 0.89 HuRI 32296183
HRAS KRAS â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
FGFR2 GRB2 â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
FRS3 KRTAP1-1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HuRI 32296183
FRS3 KPRP â—¼   PHYSICAL_INTERACTION 0.89 0.89 HuRI 32296183
KRT31 KRT76 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HuRI 32296183
KPRP STK16 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HuRI 32296183
HOXA1 KRT35 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HuRI 32296183
DMRT3 KRT34 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HuRI 32296183
FRS3 KRTAP10-8 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HuRI 32296183
CATSPER1 KRTAP1-1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HuRI 32296183
CBL PIK3R3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 25814554 17635922 10514377
RAP1B GRB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12005431 9566877 7997267
RAP1A GRB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12005431 9566877 7997267
GRB2 IKZF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 32296183 25416956 27107012
MAPK1 RAP1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 27503831 16939974 9560161
MAPK1 GATA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15967790
CATSPER1 KRTAP3-2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HuRI 32296183
NGF NTRK1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 10713102 10490030 9857023 1849459 9083066 14985763 11738045 11729324
ERBB2 PIK3R3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16273093 17496910
SOS1 KRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 25624485 23331499 16293107
NTRK2 NTF4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11738045 29997244 25241761 11855816
NTF4 BDNF â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 10631974 9519408 16189514 25241761 29997244
KARS1 PIK3R3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
DMRT3 KRTAP10-8 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HuRI 32296183
FRS3 KRT34 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HuRI 32296183
SOS1 HRAS â—¼   GTPASE_REACTION ✅ + 0.9 0.9 Signor 23132018
FRS3 KRT31 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HuRI 32296183
GRB2 SOS1 â—¼   RELOCALIZATION ✅ + 0.9 0.9 Signor 23452850
DMRT3 KRT31 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HuRI 32296183
COL8A1 KRTAP10-8 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HuRI 32296183
DMRT3 KRTAP1-1 â—¼   PHYSICAL_INTERACTION 0.91 0.91 HuRI 32296183
KRT31 STK16 â—¼   PHYSICAL_INTERACTION 0.91 0.91 HuRI 32296183
GRB2 CBL â—¼   RELOCALIZATION ✅ + 0.91 0.91 Signor 11823423
GRB2 SPRY2 â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
KRTAP10-8 KRTAP3-2 â—¼   PHYSICAL_INTERACTION 0.91 0.91 HuRI 32296183
CATSPER1 KRT31 â—¼   PHYSICAL_INTERACTION 0.91 0.91 HuRI 32296183
COL8A1 HOXA1 â—¼   PHYSICAL_INTERACTION 0.91 0.91 HuRI 32296183
GRB2 ERBB2 â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 16273093 5218056
HOXA1 KRT31 â—¼   PHYSICAL_INTERACTION 0.92 0.92 HuRI 32296183
HOXA1 KRTAP11-1 â—¼   PHYSICAL_INTERACTION 0.92 0.92 HuRI 32296183
CATSPER1 KRTAP10-8 â—¼   PHYSICAL_INTERACTION 0.92 0.92 HuRI 32296183
CATSPER1 KPRP â—¼   PHYSICAL_INTERACTION 0.92 0.92 HuRI 32296183
CBL SH3KBP1 â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
KRTAP1-1 STK16 â—¼   PHYSICAL_INTERACTION 0.92 0.92 HuRI 32296183
BDNF NTF3 â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
KRTAP10-8 STK16 â—¼   PHYSICAL_INTERACTION 0.93 0.93 HuRI 32296183
NTRK3 NTF3 â—¼   PROTEIN_INTERACTION 0.93 0.93 HIPPIE 9488719 10713102 9973222 8621424
HOXA1 KRTAP1-1 â—¼   PHYSICAL_INTERACTION 0.93 0.93 HuRI 32296183
HOXA1 KPRP â—¼   PHYSICAL_INTERACTION 0.93 0.93 HuRI 32296183
SOS1 HRAS â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 17084389 5219305
KRTAP1-1 KRTAP10-8 â—¼   PHYSICAL_INTERACTION 0.94 0.94 HuRI 32296183
HOXA1 KRTAP10-8 â—¼   PHYSICAL_INTERACTION 0.94 0.94 HuRI 32296183
GRB14 FGFR1 â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 10713090 20932831
NTF4 NTRK2 â—¼   PHYSICAL_INTERACTION 949.0 0.95 STRING 36370105
ERBB2 GRB2 â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
ID2 TCF4 â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
GRB2 CBL â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 5220480 7642581
CD2AP GRB2 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 10339567 19380743 21706016 21988832
FGF23 FGFR1 â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
BDNF NTF4 â—¼   PHYSICAL_INTERACTION 964.0 0.96 STRING 36370105
SH3KBP1 CBL â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 6170483 15090612
CD2AP CBL â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 15128873 25036637 17072306 22706086 33627783 12672817 25872741 12559036 12618476 17188587 11067845 17020880
SOS1 GRB2 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 5220480 7642581
ERBB2 GRB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 9710588 11173924 21278786 16713569 9756944 24189400 31980649 22973453 24658140 30898150 16273093 17875712 16729043 11606575 8665853
NGF NTRK1 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
HRAS SOS1 â—¼   PHYSICAL_INTERACTION 989.0 0.99 STRING 36370105
CBL SPRY2 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
CBL GRB2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
GRB2 SOS1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
GRB2 CBL â—¼   PROTEIN_INTERACTION 1.0 1.0 HIPPIE 31980649 8649804 8995445 25036637 23799367 11997436 8943292 9242692 10570290 8662998 11399323 10086340 7642581 9108392 20936779 11133830 8626404 17094785 8063801 9129019 8900205 15210722 8621483 25872741 25814554 9178909 16906159 8950973 17971399 10025673 9295052 19380743 9716598 16713569 11964172 9234717 8083187 7537740 8824292 9259313 9311917 7791764 17072306 14725908 33627783 9461587 9434624 9851874 8695851 12839496 17944804 11792427 10204582 8621719 11823423 9541596 33961781 169092 11263968 98621719 28514442 18273061 7592693 9174058 21706016 8995358 9872323 9233773 9367879 7544353 12941616 10829062 20124286 917890 15677445 9092538 10521482 8647120 19836242
GRB2 CBL â—¼   ENZYMATIC_REACTION ✅ 26.0 1.0 ACSN 10086337 10426994 10567412 10811803 10982827 11447289 11777939 11777960 11907067 12175651 12640133 15536084 15567848 15574420 16339513 16582911 16713974 16887996 17070508 17100878 17496910 17673906 18490724 19449109 26552706 8551221
CBL RAP1A â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 11353765 15169881 15308668 16000375 16076871 18835194 19454690 20189481 22464172
SPRY2 CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 33.0 1.0 Omnipath 21596750 15004239 16479008 18273061 11053437 16893902 15962011 12593796 17974561 12234920 12593795 17255109 20461437 12815057 11983899 20877636 20124286 20622121 16246327
SH3KBP1 CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 74.0 1.0 Omnipath 20130058 20711168 12618476 11894095 16407834 16713569 11071869 19268472 25472714 17306257 22262777 15456872 11152963 10679202 15962011 25036637 15107835 22833562 11067845 11894096 12177062 17675467 21830225 12135478 24167568 16228008 12874286 17072306 15090612 14596919
CBL GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 158.0 1.0 Omnipath 11823423 8621483 9242692 18273061 17635922 16906159 8626404 8662998 9108392 9541596 98621719 9295052 25872741 17372273 8824292 8943292 12941616 20124286 19531499 10086340 8063801 9129019 9590251 11263968 9461587 7642581 10521482 10204582 8995445 8900205 7592693 9716598 8083187 14725908 17904548 7791764 9178909 25036637 8695851 19836242 7537740 15210722 9108316 169092 9311917 10514377 9092538 17072306 19380743 9872323 9234717 11997436 23799367 9434624 16713569 10829062 9367879 11964172 12839496 15677445 9851874 11792427 17094785 20936779 10570290 917890 17944804 25814554 17971399 11133830 8950973 21706016 8995358 9233773 10025673 8621719 11399323 9259313 9174058 8649804
CBL ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 25102001 20332299 17635922 10514377
FGFR1 GRB2 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 17505008 18757403 21666749 11689702 11739186 18381441 19809159 21160078 14534538 15448205
FGF19 GRB2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11353842 9632781 14534538 9182757
FRS3 GRB2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11353842 8780727 11447289 7559490 9182757
FGFR4 GRB2 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 17505008 18757403 21666749 11689702 11739186 18381441 19809159 21160078 14534538 15448205
GRB2 FGF23 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11353842 9632781 14534538 9182757
GRB2 KL â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11353842 9632781 14534538 9182757
GRB2 KLB â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11353842 9632781 14534538 9182757
SOS1 GRB2 â—¼   PROTEIN_INTERACTION 1.0 1.0 HIPPIE 28514442 16520382 31980649 32062451 8493579 21988832 14679214 7510700 7514169 21706016 10319320 32203420 9872323 9797459 34407391 16906159 10716926 12577067 8810325 7629168 11960376 7664271 8626525 15192046 7629138 11997436 8943292 10207103 8695800 10570290 10025673 8112292 11726515 8816480 20473329 7559490 7773779 9447984 19380743 7642581 7527391 9716598 9344843 10477741 16713569 19323566 7516467 17474147 9569023 8188688 16893902 11964172 9478994 33961781 8479541 28166272 9009162
HRAS GRB2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
KRAS GRB2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
SPRY2 GRB2 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 11447289 11997436 15173823 17496910
NRAS GRB2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
ERBB2 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 31980649 9756944 21278786 16273093 24189400 11173924 9710588 24658140 11606575 14967450 17875712 16713569 16729043
FGFR2 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 22726438 19735729 26103942 20554525 23420874
NTRK1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11733534 10748052
SPRY2 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 17496910 11447289 10940627 11997436 16189514 12402043 16339969 15173823 16893902
GRB2 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 145.0 1.0 Omnipath 9544989 9872323 7642581 15746962 11726515 8621483 23334917 16520382 11997436 21706016 10359574 8950973 7664271 16713569 16893902 16906159 21988832 19323566 9009162 10716926 11964172 7629168 9815779 10592173 9716598 8647802 28166272 7773778 7773779 18778683 8188688 10319320 8810325 9344843 23452850 11960376 8816480 10025673 7510700 8940013 12955078 9697839 12345678 10477741 8493579 8943292 12577067 7862167 9199344 8112292 7898932 10207103 8695800 19531499 10570290 7760801 20005866 19380743 9447984 8235613 8479540 7527391 14679214 8479541 17474147 7514169 7629138
GRB2 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17496910 16713569 17673906 11352655
NRAS MAPK1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
HRAS MAPK1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
FGFR4 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
FGFR3 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
NPM1 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 31434245 22955283 12748172 16009132
FGFR1 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
FGF19 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
FGFR2 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
MAPK1 FGF23 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
MAPK1 KL â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
MAPK1 KLB â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
MAPK1 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 27342992 23405013
MAPK1 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 23331499 10197981 8816480 9922370 8626428
FRS3 NPM1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 18452557 19459784 19456272 17086210 20454865
FRS3 FGFR4 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 10629055 19187780 9660748 15094036
FRS3 FGFR1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 10629055 19187780 9660748 15094036
FRS3 FGF23 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 10629055 19187780 9660748 15094036
FRS3 FGFR2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 10629055 19187780 9660748 15094036
FRS3 FGF19 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 10629055 19187780 9660748 15094036
FRS3 FGFR3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 10629055 19187780 9660748 15094036
FRS3 KL â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 10629055 19187780 9660748 15094036
FRS3 SOS1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11353842 8780727 11447289 7559490 9182757
FRS3 KLB â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 10629055 19187780 9660748 15094036
NTRK2 FRS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11432792
ID3 TCF4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 11591653 25609649 9242638 25416956 8999959 16189514
HRAS FGFR1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
HRAS FGFR4 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
HRAS SOS1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
SPRY2 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17496910 11997436 15173823 11447289
SOS1 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 12628188 10208427 16713569 10913276 23331499 18454158 15507210 10592173 17673906 17496910 26721396 20133692 19141281 23132018 11560935 9447984 9690470 17084389
NGF NTRK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 50.0 1.0 Omnipath 17145710 8155326 9083066 11729324 27908981 22666365 17404842 24224055 25611061 14985763 9290260 9857023 28090201 12067229 23772401 10490030 11114882 27229480 1706478 11738045 10713102 9547236 1849459 9775403 17409494
FGFR1 FGF23 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 1379698 16507368 8622701 11294897 17086194
FGFR1 SOS1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11353842 8780727 11447289 7559490 9182757
KRAS FGFR1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
NRAS FGFR1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
FGF23 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 27879395 19966287 16597617 16081635 22393163 25772309
FGF19 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 22442730 16597617 25772309
FGFR1 GRB14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 10713090
FGFR2 SOS1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11353842 8780727 11447289 7559490 9182757
FGF19 FGFR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16597617 25772309
FGF23 FGFR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 16597617 16081635 12032146 1608163512032140
FGFR3 SOS1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11353842 8780727 11447289 7559490 9182757
FGF23 FGFR3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 16597617 12032146 25772309
FGF19 FGFR3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16597617 25772309
NTF3 NTRK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 27908981 17439940
NTF4 NTRK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11114882
NTRK1 MATK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 10329710
FGFR4 SOS1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11353842 8780727 11447289 7559490 9182757
FGF19 SOS1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11353842 8780727 11447289 7559490 9182757
SOS1 KLB â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11353842 8780727 11447289 7559490 9182757
SOS1 FGF23 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11353842 8780727 11447289 7559490 9182757
SOS1 KL â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11353842 8780727 11447289 7559490 9182757
SOS1 SH3KBP1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11071869 22262777 9697839 21822214
NRAS SOS1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
KRAS SOS1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
SOS1 NRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 7923364 11560935 9690470 21779497 8493579
NTF4 NTRK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 11738045 767991211855816 25241761 7679912 27908981 9775403 11855816
NTF4 BDNF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 25241761 7703225 29997244 16189514 10631974
KRAS FGFR4 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
NTF3 BDNF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17145710 7703225
BDNF NTRK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 76445409312147 7679912 21849472 27908981 9312147 23331499 9648856 11855816 26899129 7644540 1645620 26740873 9775403 21651720 28679669
BDNF NTF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17145710 7703225
FGF23 FGFR4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16597617 16081635 25772309
NRAS FGFR4 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
FGF19 FGFR4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 19706524 22442730 16597617 1473096710525310 31529503 14730967 10525310 25772309
NTF3 NTRK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 1653651 23331499 10713102 7679912 27908981 9488719 9775403 9973222
NTF3 NTRK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 27908981 8621424