Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
GRB2 ATAD3A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
FYN BCL3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7208271 16099425
STAT3 BCL3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16732314 16293640
LYN CBL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5220991 8621719
FYN CBL â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 5220480 7642581
SHC1 CBL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5220991 8621719
ITCH CBL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12226085 5215735
FYN CBL â—¼   PHOSPHORYLATION ✅ 0.8 0.8 mint 5217342 15556646
CBL FYN â—¼   PHOSPHORYLATION ✅ 0.8 0.8 mint 5217342 15556646
CBL SRC â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5219404 17141222
CBL FGFR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBL PIK3CG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17635922 10514377
CBL ITGA5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9663390 15728256
GRB2 DDX39B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 DST â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
EPHA2 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 7982920
PTPN6 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10660620 6671678
FYN GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9694876 7737275
LYN GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9209406 8400282
GRB2 LUZP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 SRSF10 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 PRKDC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 MPRIP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 RUVBL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 PKM â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 XRCC6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 CTTN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
MAPK3 GRB2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7739560 8816480
GRB2 PTPN11 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 Reactome 17993263 15031289
MAPK1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8994038
FGFR1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9480847 16713569
STAM2 HGS â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
GGA3 HGS â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15611048 5217420
HGS NEDD4 â—¼   UBIQUITINATION ✅ 2.0 0.8 intact 12230472 5215741
TRIP10 LYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5215944 12456510
SHC1 LYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7516469 5220322
LYN PLCG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15644415 8034732
LYN PIK3R1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11598010 12506011
LYN PIK3R5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11598010 12506011
SRC MAPK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16580177 9924018
MAPK1 RPS6KA1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12832467 16626623
MAPK1 RPS6KA3 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12832467 16626623
MAPK1 MAP2K1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 23241949 8412360
MAPK1 PTPRR â—¼   COLOCALIZATION 2.0 0.8 intact 10601328 8213378
RPS6KA1 MAPK1 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
PRKCE MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11350735
SRC MAPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16580177 9924018
MAPK3 RPS6KA1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12832467 16626623
MAPK3 RPS6KA3 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12832467 16626623
PRKCE MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16810323 16461926
EGF MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17081983 16024629
SSRP1 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9472631 12374749
PTEN MPRIP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
CSDE1 PIK3R1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
PLCG1 PIK3R1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6805619 9020117
CSDC2 PIK3R1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
PIK3R1 SOS2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
PIK3R1 GAB1 â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 10978177 6731241
EGF PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 19531499
PIK3R1 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 25814554 15021914
E2F4 PRKDC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18319725 16135806
PLCG1 PTPN11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6805619 9020117
PDGFA PTPN11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7691811 9739761
PDGFB PTPN11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7691811 9739761
FRS2 PTPN11 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
GAB1 PTPN11 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 intact 8288622 20308328
PTPN11 SRC â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 intact 8288622 20308328
PTPN11 KRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 26617336
PTPN11 NRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 26617336
PTPN11 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 26617336
STAT3 PDGFB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7876144 8662928
PTPRR STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17360477
HADHA TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
FGFR2 FGF10 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12591959 5216141
FGF9 FGF10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 8663044
E2F4 E2F3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17531812
CEBPB E2F4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16959612
SMAD4 E2F4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12150994
E2F4 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15580623 18319725
SRC SHC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10964917 8755247
INS SHC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8702728 10218944
IGF1 SHC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8033892 7559507
SHC1 FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7516469 5220322
FGFR1 SHC1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 17496910 25467007
HRAS SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17138645
PTPN6 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8541543
EGF SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19531499 17673906
SOS2 CRK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
PDGFB SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15845350 12753909
SEC24B PLCG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
PLCG1 KLB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16844695 10652257
PLCG1 FGFR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16844695 10652257
PLCG1 FGF23 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16844695 10652257
PTPN6 STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12220225
SOS2 FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
SRC FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219079 16966330
PIK3R2 FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15536084 11907067
SMAD4 CEBPB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12202226 5215691
SMAD4 SPP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21294585 11042172
SMAD4 E2F5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12150994
POU2F1 PLAU â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10951201
RUNX2 MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19915614 16166639
IGF2R GGA3 â—¼   COLOCALIZATION 2.0 0.8 intact 16977309 5219086
HRAS STAM2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HRAS SRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12695509 5216326
HRAS CCDC120 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HRAS EGF â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
RUNX2 SMURF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24631292 23042144
PPARG POU2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12881480
PPARG SPP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11861425 11426586
E2F3 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12110166 18319725
SOS2 SRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
M6PR GGA3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 11387475 5214102
SCYL2 ZFYVE9 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
ZFYVE9 ERBIN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
ACBD3 SMURF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
CANX SMURF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
EGF ERBIN â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23220880 22908275
KRAS EGF â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
NRAS EGF â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
KLB FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17623664 29648978
FGFR2 FGF9 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18552176 18757403
STAT5A INS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11415999 10373481
CANX CEP250 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
SOAT1 CANX â—¼   COLOCALIZATION 2.0 0.8 intact 8372609 22045338
MON2 GGA3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6629694 18418388
PIK3R2 PIK3CG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8596638 11733063
MTA1 MTA3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 26028330 18719363
FGF6 FGF9 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18552176 18757403
SOS2 HRAS â—¼   GTPASE_REACTION ✅ + 0.8 0.8 Signor 21779497
IP6K1 UBXN4 â—¼   PHYSICAL_INTERACTION 801.0 0.8 STRING 36370105
CRK GRB2 â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
FGFR1 PIK3R1 â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
MDM2 XRCC6 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 24583282 18784078 24147044 19247369
SHC1 FGFR1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 16189514 16713569 7514169 7559490 18022941
FGFR1 CRK â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 10464310 25241761
PTEN WWP1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 33470109 21532586 25547115
ITCH TRAF6 â—¼   PHYSICAL_INTERACTION 813.0 0.81 STRING 36370105
FGFR1 CDC37 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31980649 18022941
LYN FRS2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 23503679
PDGFB MDM2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
SHC1 PIK3R1 â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 16219545 5217992
MRAP2 FGFR2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
FGF1 SDC2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 26186194
LITAF FGFR1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
FGFR2 FGFR1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
GOPC TFAM â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
SDC2 FGFR2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
LITAF FGFR2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
FGFR2 IFFO2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
FGFR2 UBXN4 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
FGFR2 XPR1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
FGFR2 TIMP1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
FGFR2 IP6K1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
PIK3CG PIK3R5 â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
KHDRBS1 LYN â—¼   PHYSICAL_INTERACTION 822.0 0.82 STRING 36370105
KRAS MAPK1 â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
APBB2 APBB1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
CBL ITCH â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 12226085 19341794
MAPK1 PTPRR â—¼   PHOSPHORYLATION ✅ + 0.83 0.83 Signor 11493009
PTPRR MAPK1 â—¼   DEPHOSPHORYLATION ✅ - 0.83 0.83 Signor 11493009
LRRK1 SHC1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 24947832 31980649 20697350
SHC1 SOS2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 10675333 19380743
EPHA4 FGFR1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 16365308 18790757
ITCH LITAF â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 21326863 25963657
UBXN4 IP6K1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26389662 26186194
APBB2 GOPC â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
FGFR1 KAL1 â—¼   PHYSICAL_INTERACTION 832.0 0.83 STRING 36370105
FGFR1 KLB â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
SRC CBL â—¼   PHYSICAL_INTERACTION ✅ 0.84 0.84 mint 6538879 18273061
SRC CBL â—¼   PHOSPHORYLATION ✅ 0.84 0.84 mint 5219404 17141222
CRK SRC â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 23397142 10962563 12615911
FGF6 FGFR1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 18199118 14613973 8663044
GGA2 GGA3 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 14638859 31076515
KRAS NRAS â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
SRC GRB2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 16189514 16713569 11964172 9016807 12624098
SHC1 LYN â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 7516469 7650013
SRC LYN â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 32707033 9169421 18070987 22581261
SUPT16H SSRP1 â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 5218941 16902406
PLCG1 SHC1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 8662733 8155326 10652211
CRK FRS2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 12154000 10092678
SRC PLCG1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 1689310 7510703 16713569 7682059 8657103 8885868
KHDRBS1 FYN â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 8374603 22641034
FGFR1 FGF9 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 14613973 18199118 10574949
GGA2 SYNRG â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 10747088 10814529
MTMR9 MTMR6 â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 27880917
MTMR6 MTMR9 â—¼   PROXIMITY ✅ 0.85 0.85 mint 27880917
CBL EPHA2 â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
NEDD4 SMURF2 â—¼   PHYSICAL_INTERACTION 858.0 0.85 STRING 36370105
FYN BCL3 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16099425 16713569 9576921
PIK3R1 GRB2 â—¼   PHYSICAL_INTERACTION ✅ 0.86 0.86 mint 5220480 7642581
XRCC6 SSRP1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 28514442 30585729
TRAF6 SRC â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 10635328 16189514 22447928 29545793
CRK SHC1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 8035825 9837978 9461587 9617486 19380743 10464310 23397142
FGFR1 FGF8 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 18199118 25241761 10574949 22244757
STAM USP8 â—¼   PHYSICAL_INTERACTION 860.0 0.86 STRING 36370105
MAPK3 RPS6KA3 â—¼   PHYSICAL_INTERACTION 861.0 0.86 STRING 36370105
MAPK1 SHC1 â—¼   PHYSICAL_INTERACTION 862.0 0.86 STRING 36370105
FGFR1 FRS2 â—¼   PHOSPHORYLATION ✅ + 0.86 0.86 Signor 9182757
GRB2 LRRK1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 31980649 24947832 19380743 20697350
HGS GGA2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 15611048 19019082
LYN GAB1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 34079125 24728074
CRK SOS2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 17474147 33961781 19380743
MMP9 TIMP1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 24330623 33961781
MTA3 MTA1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 21258344 24981860 26344197
LYN PTPN6 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
KHDRBS1 PLCG1 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
CDCA3 CTDSP1 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
CDCA3 CTDSPL â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
CRK SRC â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
PIK3R1 PIK3R2 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
CTDSP1 CTDSPL â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
SRSF10 TRA2A â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
PIK3R1 SHC1 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
HRAS NRAS â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
HGS NEDD4 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16713569 12230472 23602387 25588945 20675381
SHC1 SRC â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
EPHA4 FYN â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 31413325 16189514 16713569 12084815
SMURF1 SMURF2 â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
MTMR6 MTMR9 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
CBL PLCG1 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
GRB2 KHDRBS1 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
CRK PIK3R1 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
SRC STAT3 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
FYN KHDRBS1 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
MAPK1 MAPK3 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
RNF41 USP8 â—¼   UBIQUITINATION ✅ - 0.88 0.88 Signor 23750007
USP8 RNF41 â—¼   DEUBIQUITINATION ✅ + 0.88 0.88 Signor 23750007
CBL SHC1 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
CBL PIK3R2 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
FRS2 GRB2 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
FRS2 CBL â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17944804 11997436 20038681
FGFR2 GRB2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24440983 22726438
MAPK1 STAT3 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
GAB1 CRK â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 12138161 16713569 24728074 19380743
SOS2 PLCG1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17474147 10940929
SRC FYN â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 31980649 19711372 9169421 33961781 16966330
SMAD4 CEBPB â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 12202226 16959612 12524424
FGF23 FGFR1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 22393163 27879395 19966287 17086194
PIK3R1 SRC â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
MORF4L1 RUVBL2 â—¼   PHYSICAL_INTERACTION 891.0 0.89 STRING 36370105
HRAS KRAS â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
FGFR2 GRB2 â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
CBL LYN â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
KHDRBS1 SRC â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
FRS2 PTPN11 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
FGFR1 FRS2 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
SRC CBL â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 29899407 17094785 16713569 18273061 7782294 12941616 10829062 31120930 15135048 17141222 18996392 8635998 11994282 22203672 19861161 16636290
PTPN6 CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11157475 12176909
CDC37 SRC â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 32707033 33961781 31980649 11085988
NRAS CDC37 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16024644 15118125 15284455
KRAS CDC37 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16024644 15118125 15284455
HRAS CDC37 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16024644 15118125 15284455
PDGFB GRB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 7935391 8388543 9739761
PDGFA GRB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 7935391 8388543 9739761
FYN GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7499280 9344857
HGS ZFYVE9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 11094085
HMGB2 POU2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7720710 16189514
LYN STAT5A â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 9837784 22509308 8861946
LYN STAT5B â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 9837784 22509308 8861946
LYN PIK3CG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10318860
MAPK1 MAP2K1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 10567369 19219045 8013650
MAPK1 PTPN6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16231973 12459785 23109003
MAPK1 FRS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12419216 12974390
MAPK3 MAP2K1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 10567369 19219045 8013650
MAPK3 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15930121
MAPK3 PTPN6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16231973 12459785 23109003
MAPK3 PTPN11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 8197172
PRKDC MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17570479 22444248 10721693
FGFR1 NEDD4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19953087 25292214 21765395
NEDD4 PTEN â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19345329 33712741 31469661 29593330 21986318 31578285 25047839 27295432 18498243 24063548 28437168 24141722 18307411 25547115 30594392
PDGFA PIK3R1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 2466336 1374684 9739761
PIK3R1 PIK3CG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8596638 14665640 11733063
XRCC6 PRKDC â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 20711232 21575865 33005030 28345663 15941674 10064605 26496610 26446488 15520013 10750018 8422676 26175416 22939629 17308091 30585729 19303849 21969602
FRS2 PTPN11 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 11447289 17673906 25772309
SSRP1 INS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12437983 12684063 10385428
SRC STAT3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 21573184 15313931 11294897 8657134 18070987 10918587 12244095 19372587 12626508 8626374 14551213 16713569 8272872 11350938 9566874 12576423 11940572 15735682
PTPN6 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18508557 15870198 10545526
FGF10 FGFR2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 25241761 12591959 10339576 18199118 9582367
PPARG CD83 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20672290 15356156
E2F4 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15711575 12110166 18319725
PDGFC SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12767520 17496910 17673906
PTEN SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10427092 21206972
PDGFD SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12767520 17496910 17673906
PDGFA SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12767520 17496910 17673906
PDGFB CRK â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10508235 9546424 9739761
PDGFA CRK â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10508235 9546424 9739761
PIK3R2 PDGFB â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 2466336 1374684 9739761
PDGFB PLCG1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 1396585 8443409 9739761
EGF PLCG1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 8940074 1672440 10473558
PLCG1 FGFR1 â—¼   PHYSICAL_INTERACTION ✅ 0.9 0.9 mint 8321198 6730542
FGFR1 PLCG1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12601080 1689310 1656221 25241761 23063561 8321198 9660748 20932831 18022941 19665973 15117958
FGFR2 PLCG1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15629145 24440983 25241761 7999363
SRC PLCG1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 15879121 20807769 11600407
FGFR1 PLCG1 â—¼   PROXIMITY ✅ 0.9 0.9 mint 8019672 20932831
PLCG1 FGFR1 â—¼   PROXIMITY ✅ 0.9 0.9 mint 8019672 20932831
EGF PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23613900 17081983 16525023
PTPN6 STAT5B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12220225 9211920
SMAD4 BGLAP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11278818
TIMP1 MMP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 24330623 19010413
MMP9 TIMP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 24330623 19010413
HRAS SDC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15752734 16997272 32196115
PPARG IGF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18394717 20064783 20685873
ITGA5 SPP1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10673366 8910476 10593924
FLT4 RPS6KA3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12601080
SRC KRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 30644389 26854235 9096340
STAT5A EGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18996136 12697691 21617857
EGF PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17496910 1334406 19531499
POU2F1 SPP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12650610 11126367
KLB FRS2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10629055 9660748 18373495
FRS2 FGF23 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10629055 9660748 18373495
CEBPB FGFR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8183933 12184911 21562223
RUNX2 FGFR2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15829502 22972545 19259985
CEBPB RUNX2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17579210 21302301 21612856
CEBPB RUNX2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15713650 11668178
STAT5B INS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10830280 10821852 10373481
PIK3CG GAB1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10194437 12506011 10455108
GAB1 PIK3CG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10871282 8596638
CTDSP1 CDCA3 â—¼   PHYSICAL_INTERACTION ✅ 0.9 0.9 mint 27880917
GAB1 PIK3R5 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10194437 12506011 10455108
PIK3R2 PDGFA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 2466336 1374684 9739761
RCC1 PKM â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
MTMR6 MTMR9 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 32296183 25416956 25659891 27880917 12890864 33961781 21516116 26344197
STAT5B STAT5A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15043997 17997837 14532269
STAT5A STAT5B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21542777 15043997 17997837
MAPK1 RPS6KA3 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
NEDD4 PTEN â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
GAB1 PIK3R1 â—¼   PHYSICAL_INTERACTION 907.0 0.9 STRING 36370105
GRB2 PIK3R1 â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
MAPK1 PTPRR â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
FLT4 SHC1 â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
PIK3R1 PTPN11 â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
GRB2 CBL â—¼   RELOCALIZATION ✅ + 0.91 0.91 Signor 11823423
FYN CDC37 â—¼   PROTEIN_INTERACTION 0.92 0.92 HIPPIE 28514442 25036637 31980649 33961781 32707033
CBL FYN â—¼   PHYSICAL_INTERACTION 925.0 0.92 STRING 36370105
SOS2 GRB2 â—¼   PHYSICAL_INTERACTION ✅ 0.93 0.93 mint 5220477 7629138
GGA3 M6PR â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
CBL SRC â—¼   PHYSICAL_INTERACTION 936.0 0.93 STRING 36370105
XRCC6 PRKDC â—¼   RELOCALIZATION ✅ + 0.93 0.93 Signor 19133841
PIK3R1 CBL â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 5217342 15556646
FGF1 FGFR1 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
HRAS PIK3CG â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
GRB2 PTPN11 â—¼   PHYSICAL_INTERACTION 949.0 0.95 STRING 36370105
GRB2 CBL â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 5220480 7642581
SHC1 CBL â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 10570290 10025673 16713569 8621719 9541596 8662998 9461587 9434624 9234717 8950973 19380743 15677445
CBL LYN â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 7721825 12149655 9160881 18235045 8621719 7782294 12244174 15190072 33512474 32707033
PLCG1 GRB2 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 16713569 7629168 7516467 9020117 21706016 10940929 16038803 9281317
FRS2 GRB2 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 16189514 8780727 16893902 22974441 21706016 10092678 9182757 11997436 25159185 15004239 12402043 34407391
HGS STAM2 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 16189514 15113837 16713569 12551915 20504764 13679051 22939629 26344197 16429130
PTPN11 GAB1 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 6169284 14701753
PTPN11 GAB1 â—¼   DEPHOSPHORYLATION ✅ 0.96 0.96 mint 20308328 8288622
GAB1 SHC1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 9804835 24728074 12808090 14982882
GAB1 PLCG1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 8596638 11507676 24728074
FGFR2 PLCG1 â—¼   PHYSICAL_INTERACTION 962.0 0.96 STRING 36370105
MAP2K1 MAPK3 â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
FGF23 FGFR1 â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
FYN SRC â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
FYN CBL â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 17094785 8900205 15190072 9890970 25814554 8995358 12244174 10829062 12941616 9311917 12231245 16503409 9677430 8662998 119942 9535867 10092522 15208330 7642581 15556646 16713569 8621719 10629042 7782294 8626543 10799548 11239464
PLCG1 CBL â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 16503409 12803489 9712732 25241761 16713569 16467851 12061819 12941616 9234717 17372230
CBL CRK â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 31980649 9129019 9416834 22974441 8621483 25814554 9178909 15581361 18835194 8943292 12393469 8524328 8683103 8662998 10962563 9461587 19380743 16289966 11792427 8626543 9988765 33961781 9617486 8626404
SHC1 GRB2 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 8940013 6169950
GAB1 GRB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 11314042 22536782 10871282 31980649 10913131 11960376 9804835 9890893 20473329 21706016 33961781 20936779 19380743 9242692 8596638
CRK GRB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 8810325 10962563 8662907 19380743 10970810
LITAF NEDD4 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 27927196 16118794 11042109 33961781 25963657
SRC SHC1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 10482988 16189514 7499252 9096689 9710204 18840094 8939605 9388490 26551075
FGFR2 FGF1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 1697263 25241761 9700203 7499435 8576175 22955284 10618369 11069186 10339576 33961781 14732692 8663044 23597563 18199118 11714710
FGFR1 FRS2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 9632781 16189514 21765395 10629055 9660748 18022941 11877385 10464310 11090629
HGS STAM2 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
GRB2 SOS2 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
MAP2K1 MAPK1 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
RNF41 USP8 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
FGF10 FGFR2 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
FGFR1 PLCG1 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
MAPK1 RPS6KA1 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
PRKDC XRCC6 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
FGF1 FGFR2 â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
SHC1 GRB2 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 12485888 21725358 31980649 9126968 7514169 7744881 8235613 11453982 8662733 8491186 7629070 8940013 10570290 8112292 12213123 11302736 8662998 8195171 7597091 8810340 32062451 9129019 16371368 12149229 10049786 8626525 7650032 8950973 9488479 24189400 15812354 12441060 19380743 26551075 22057045 10477741 28690151 16713569 7516467 9733714 11827484 11964172 7537740 16520382 9019162 8663178 9797459 9032244 12577067 9927207 7524086 8995379 9886492 8294403 7559490 9434624 11792427 7798267 8621719 9541596 15688026 12898421 33961781 11370743 25416956 9544989 22974441 8939605 21706016 9083103 7535773 11505033 9175774 24430869 10080542 9020193 9045692 10356320 15888547 9254595 8561895 11707405 8647288
SOS2 GRB2 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 28514442 31980649 32062451 21988832 17474147 14679214 21706016 7629138 33961781 20936779 10940929 19380743 32203420
FGFR1 FGF1 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 16189514 25241761 10748122 8321198 23597563 1309595 11714710 9624181 11030354 7730326 11032250 28769084 1697263 22244757 1722683 22955284 10336501 8756477 18261743 18441324 1709094 8576175 33961781 8692946 1383494 18199118 10830168 14613973
GGA2 IGF2R â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
GAB1 GRB2 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GGA3 IGF2R â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CBL CRK â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
HGS STAM â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
CBL GRB2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CBL PIK3R1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
GAB1 PTPN11 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
SSRP1 SUPT16H â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
MAPK1 APBB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 14697653
STAT3 BCL3 â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10347215 11875494 12193690 12223527 12907458 14607900 14670306 15218058 15356132 15465827 15573129 16418395 17404308 18776941 19380816 20093776 20237412 20406969 20435894 20580461 20581311 21372296 21765015 21840487 22461508 23124025 23390297 23454751 23953057 24857661 27216177 28186502 7543512
HGS CBL â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 24828152 12686592 12551915 15828871 19109251
EGF CBL â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 17177598 16187797 15284455 16849543 16969069 16953218 17699773 17372273 17712310
STAM2 CBL â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 24828152 12686592 12551915 15828871 19109251
CRK CBL â—¼   PHYSICAL_INTERACTION 9.0 1.0 ACSN 11353765 15169881 15308668 16000375 16076871 18835194 19454690 20189481 22464172
CBL CDC37 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 17177598 16187797 15284455 16849543 16969069 16953218 17699773 17372273 17712310
CBL STAM â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 24828152 12686592 12551915 15828871 19109251
GRB2 CBL â—¼   PROTEIN_INTERACTION 1.0 1.0 HIPPIE 31980649 8649804 8995445 25036637 23799367 11997436 8943292 9242692 10570290 8662998 11399323 10086340 7642581 9108392 20936779 11133830 8626404 17094785 8063801 9129019 8900205 15210722 8621483 25872741 25814554 9178909 16906159 8950973 17971399 10025673 9295052 19380743 9716598 16713569 11964172 9234717 8083187 7537740 8824292 9259313 9311917 7791764 17072306 14725908 33627783 9461587 9434624 9851874 8695851 12839496 17944804 11792427 10204582 8621719 11823423 9541596 33961781 169092 11263968 98621719 28514442 18273061 7592693 9174058 21706016 8995358 9872323 9233773 9367879 7544353 12941616 10829062 20124286 917890 15677445 9092538 10521482 8647120 19836242
CRK CBL â—¼   SHARES_COMPLEX 9.0 1.0 ACSN 11353765 15169881 15308668 16000375 16076871 18835194 19454690 20189481 22464172
GRB2 CBL â—¼   ENZYMATIC_REACTION ✅ 26.0 1.0 ACSN 10086337 10426994 10567412 10811803 10982827 11447289 11777939 11777960 11907067 12175651 12640133 15536084 15567848 15574420 16339513 16582911 16713974 16887996 17070508 17100878 17496910 17673906 18490724 19449109 26552706 8551221
SRC CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 50.0 1.0 Omnipath 9525940 7782294 16713569 18273061 10829062 10799548 10934191 12604776 9890970 17570479 9013636 15135048 17094785 25784557 8635998 10092522 12522270 8621719 17141222 16636290 11239464 19861161 11994282 12941616 14739300 22203672 8849724 15212693
FYN CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 97.0 1.0 Omnipath 9525940 7642581 8626543 7782294 15208330 16503409 16713569 10829062 10799548 10934191 8900205 8551236 8662998 8995358 19734451 12604776 9890970 10592173 17570479 10629042 17094785 10092522 11997497 12522270 15556646 12244174 8621719 9102067 22880054 9311917 11239464 19904769 11994282 12941616 9535867 25814554 12231245 15190072
CRK CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 60.0 1.0 Omnipath 8683103 16289966 8626543 8621483 9617486 16713569 9416834 8524328 10962563 8626404 9367879 8662998 12393469 11792427 15581361 9013636 15581362 9178909 9988765 18835194 8943292 20697350 9129019 19380743 25814554 9461587
FRS2 CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 20038681 11997436
CBL GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 158.0 1.0 Omnipath 11823423 8621483 9242692 18273061 17635922 16906159 8626404 8662998 9108392 9541596 98621719 9295052 25872741 17372273 8824292 8943292 12941616 20124286 19531499 10086340 8063801 9129019 9590251 11263968 9461587 7642581 10521482 10204582 8995445 8900205 7592693 9716598 8083187 14725908 17904548 7791764 9178909 25036637 8695851 19836242 7537740 15210722 9108316 169092 9311917 10514377 9092538 17072306 19380743 9872323 9234717 11997436 23799367 9434624 16713569 10829062 9367879 11964172 12839496 15677445 9851874 11792427 17094785 20936779 10570290 917890 17944804 25814554 17971399 11133830 8950973 21706016 8995358 9233773 10025673 8621719 11399323 9259313 9174058 8649804
CBL PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 98.0 1.0 Omnipath 9092574 19190244 16289966 11406619 7642581 11133830 10358153 8941725 9234717 8612729 11157475 10620516 16713569 21203488 11418612 24113870 17635922 18374639 14530346 11526404 8662998 8995358 11030146 9890970 9541596 11042121 15581361 9890943 8080844 7791764 9178909 15107835 8995243 8695807 9988765 23109003 11944898 15556646 17237826 10025673 17722974 8621719 16135792 16107703 16219545 9461587 9160881 9414268 16982329 19861161 10514377 9918857 11087752 9092538 11994282 9259313 15790353 19531499 9174058 8702998 25814554 22315502 19380743 10918571 8896416
CBL PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 9092574 19190244 11406619 11133830 7629144 17635922 11526404 8662998 8995358 8080844 15107835 23109003 17722974 8621719 16107703 9414268 10514377 15790353 19531499 22315502 19380743 25814554 9461587
CBL PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 7517397 9712732 12941616 25241761 12061819 23109003 9234717 16503409 11709089 16713569 17372230 16467851 12803489
CBL LYN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 24.0 1.0 Omnipath 12149655 18235045 12244174 8627181 8621719 7782294 15304502 9160881 15190072 7721825
PLCG1 CDC37 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 17177598 16187797 15284455 16953218 17712310
SHC1 CDC37 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 16187797 15284455 17646646 16969069 17372273 17712310
GAB1 CDC37 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 17177598 16187797 15284455 16849543 16953218 17646646 15329413 17712310 15118073
SRC EPHA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 24457997 28957431 26788993
EPHA2 PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17496910 23331499 7982920
EPHA2 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 12400011
HGS GRB2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 24828152 12686592 12551915 15828871 19109251
FGFR1 GRB2 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 17505008 18757403 21666749 11689702 11739186 18381441 19809159 21160078 14534538 15448205
STAT5A GRB2 â—¼   PHYSICAL_INTERACTION 14.0 1.0 Reactome 16627759 22411868 11090077 26515730 20111072 15498859 10698507 12468433 12796379 30552988 23103841 31066629 15003515 17356133
STAM2 GRB2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 24828152 12686592 12551915 15828871 19109251
STAT5B GRB2 â—¼   PHYSICAL_INTERACTION 14.0 1.0 Reactome 16627759 22411868 11090077 26515730 20111072 15498859 10698507 12468433 12796379 30552988 23103841 31066629 15003515 17356133
GRB2 GAB1 â—¼   PHYSICAL_INTERACTION 50.0 1.0 ACSN 10086337 10514377 10567412 10648629 10811803 10982827 11062502 11313945 11385609 11447289 11777939 11907067 11940581 12040186 12175651 12419216 12640133 12670391 12782630 14585353 15199124 15534002 15536084 15567848 15574420 15584861 15863030 16102570 16227978 16488589 16582911 16847462 16887996 17496910 17635922 17673906 18287025 19449109 19568798 19615955 20805416 21102635 23523669 24027568 26552706 27111285 7510700 8294866 8551221 9779982
GRB2 FRS2 â—¼   PHYSICAL_INTERACTION 30.0 1.0 ACSN 10086337 10567412 10811803 10982827 11274345 11447289 11777939 11997436 12040186 12175651 12640133 14585353 15173823 15567848 15574420 15863030 16102570 16488589 16582911 16887996 17496910 17673906 19449109 19568798 24027568 25772309 26552706 6321473 7510700 8551221
GRB2 FLT4 â—¼   PHYSICAL_INTERACTION 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
GRB2 CRK â—¼   PHYSICAL_INTERACTION 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
GRB2 FGF23 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11353842 9632781 14534538 9182757
GRB2 STAM â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 24828152 12686592 12551915 15828871 19109251
GRB2 KLB â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11353842 9632781 14534538 9182757
GRB2 PLCG1 â—¼   PHYSICAL_INTERACTION 51.0 1.0 ACSN 10072481 10086337 10209041 10567412 10781611 10811803 10925299 10982827 11169415 11447289 11532940 11777939 11994416 12175651 12640133 1281218 12845332 14764585 15214048 15567848 15574420 16102570 16329184 16582911 16887996 1712101 17397400 17496910 17673906 19449109 19494291 19909365 23523669 23620508 24584707 25137453 2536067 25456276 25960930 26552706 7523143 7682895 7890616 8226994 8551221 8649391 8976179 8995379 9489702 9535722 9846483
GRB2 SHC1 â—¼   PHYSICAL_INTERACTION 69.0 1.0 ACSN 10022831 10086337 10358164 10567412 10811803 10849428 10982827 11166270 11283723 11335727 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15308668 15501236 15520864 15567848 15573129 15574420 15863030 16000375 16002046 16076871 16102570 16212621 16530705 16572188 16582911 16887996 17086423 17496910 17673906 17883421 18835194 19223473 19414323 19449109 19454690 19909365 21372296 21378271 22064427 22461508 22464172 23390297 23896411 24027568 24217602 24346288 24670066 25922287 26201938 26552706 7510700 8551221 8837607 9157999 9570538 9753319 9763606
GRB2 SHC1 â—¼   PROTEIN_INTERACTION 69.0 1.0 ACSN 10022831 10086337 10358164 10567412 10811803 10849428 10982827 11166270 11283723 11335727 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15308668 15501236 15520864 15567848 15573129 15574420 15863030 16000375 16002046 16076871 16102570 16212621 16530705 16572188 16582911 16887996 17086423 17496910 17673906 17883421 18835194 19223473 19414323 19449109 19454690 19909365 21372296 21378271 22064427 22461508 22464172 23390297 23896411 24027568 24217602 24346288 24670066 25922287 26201938 26552706 7510700 8551221 8837607 9157999 9570538 9753319 9763606
GRB2 PLCG1 â—¼   SHARES_COMPLEX 51.0 1.0 ACSN 10072481 10086337 10209041 10567412 10781611 10811803 10925299 10982827 11169415 11447289 11532940 11777939 11994416 12175651 12640133 1281218 12845332 14764585 15214048 15567848 15574420 16102570 16329184 16582911 16887996 1712101 17397400 17496910 17673906 19449109 19494291 19909365 23523669 23620508 24584707 25137453 2536067 25456276 25960930 26552706 7523143 7682895 7890616 8226994 8551221 8649391 8976179 8995379 9489702 9535722 9846483
GRB2 GAB1 â—¼   SHARES_COMPLEX 50.0 1.0 ACSN 10086337 10514377 10567412 10648629 10811803 10982827 11062502 11313945 11385609 11447289 11777939 11907067 11940581 12040186 12175651 12419216 12640133 12670391 12782630 14585353 15199124 15534002 15536084 15567848 15574420 15584861 15863030 16102570 16227978 16488589 16582911 16847462 16887996 17496910 17635922 17673906 18287025 19449109 19568798 19615955 20805416 21102635 23523669 24027568 26552706 27111285 7510700 8294866 8551221 9779982
GRB2 FLT4 â—¼   SHARES_COMPLEX 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
GRB2 CRK â—¼   SHARES_COMPLEX 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
FYN GRB2 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 9822663 15886116 10849438 12670394
HRAS GRB2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
KRAS GRB2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
NRAS GRB2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
PTPN11 GRB2 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 10358138 11447289 11572860 12138178 12707331 15240681 15699106 15713798 19833085 9751747
GRB2 FLT4 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
GRB2 FRS2 â—¼   ENZYMATIC_REACTION ✅ 30.0 1.0 ACSN 10086337 10567412 10811803 10982827 11274345 11447289 11777939 11997436 12040186 12175651 12640133 14585353 15173823 15567848 15574420 15863030 16102570 16488589 16582911 16887996 17496910 17673906 19449109 19568798 24027568 25772309 26552706 6321473 7510700 8551221
GRB2 SHC1 â—¼   ENZYMATIC_REACTION ✅ 69.0 1.0 ACSN 10022831 10086337 10358164 10567412 10811803 10849428 10982827 11166270 11283723 11335727 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15308668 15501236 15520864 15567848 15573129 15574420 15863030 16000375 16002046 16076871 16102570 16212621 16530705 16572188 16582911 16887996 17086423 17496910 17673906 17883421 18835194 19223473 19414323 19449109 19454690 19909365 21372296 21378271 22064427 22461508 22464172 23390297 23896411 24027568 24217602 24346288 24670066 25922287 26201938 26552706 7510700 8551221 8837607 9157999 9570538 9753319 9763606
GRB2 PIK3R1 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
GRB2 PLCG1 â—¼   ENZYMATIC_REACTION ✅ 51.0 1.0 ACSN 10072481 10086337 10209041 10567412 10781611 10811803 10925299 10982827 11169415 11447289 11532940 11777939 11994416 12175651 12640133 1281218 12845332 14764585 15214048 15567848 15574420 16102570 16329184 16582911 16887996 1712101 17397400 17496910 17673906 19449109 19494291 19909365 23523669 23620508 24584707 25137453 2536067 25456276 25960930 26552706 7523143 7682895 7890616 8226994 8551221 8649391 8976179 8995379 9489702 9535722 9846483
GRB2 GAB1 â—¼   ENZYMATIC_REACTION ✅ 50.0 1.0 ACSN 10086337 10514377 10567412 10648629 10811803 10982827 11062502 11313945 11385609 11447289 11777939 11907067 11940581 12040186 12175651 12419216 12640133 12670391 12782630 14585353 15199124 15534002 15536084 15567848 15574420 15584861 15863030 16102570 16227978 16488589 16582911 16847462 16887996 17496910 17635922 17673906 18287025 19449109 19568798 19615955 20805416 21102635 23523669 24027568 26552706 27111285 7510700 8294866 8551221 9779982
GRB2 FRS2 â—¼   DOWN_REGULATES ✅ - 30.0 1.0 ACSN 10086337 10567412 10811803 10982827 11274345 11447289 11777939 11997436 12040186 12175651 12640133 14585353 15173823 15567848 15574420 15863030 16102570 16488589 16582911 16887996 17496910 17673906 19449109 19568798 24027568 25772309 26552706 6321473 7510700 8551221
GRB2 FYN â—¼   DOWN_REGULATES ✅ - 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
PTEN GRB2 â—¼   REGULATES ✅ 15.0 1.0 ACSN 10648629 10753747 11747822 12040186 15584861 15721744 16288286 16982858 17218262 19847259 22179046 22465479 23732914 24254977 25364523
PTEN GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16288286 10648629 17218262 12040186 15584861
SHC1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 198.0 1.0 Omnipath 8808684 9083103 8551221 9126968 8621483 25416956 9252386 8524223 7535773 8662998 11302736 11827484 8995379 9541596 9175774 10207047 7717978 17673906 7744881 11505033 10523831 24189400 9927207 7650032 8810340 9045692 23178716 19531499 15812354 9129019 10356320 12485888 9461587 8114695 7514169 9566877 8939605 16371368 15341520 7529871 10891441 10749687 7524086 26645482 8491186 10592173 10049786 9171350 11707404 7537740 15688026 8663178 19380743 11782427 9544989 16436051 9434624 16713569 21725358 11964172 17314098 11792427 8195171 1465135 12213123 8647288 12955078 10477741 11707405 12577067 9199344 10080542 8112292 7760801 10570290 11997181 7798267 16520382 10961885 8950973 21706016 9448048 8662733 11370743 8051109 9733714 8621475 9254595 8294403 10748054 8621719 8940013 12441060 22057045 7505797 24737791 20697350 9886492 18174162 18273058 8235613 7963520 7523859
FLT4 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9927207 8662748 7675451 7970715
FGFR2 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 22726438 19735729 26103942 20554525 23420874
EGF GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17081983 19531499 17673906 10973965
PTPN11 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 66.0 1.0 Omnipath 8702859 9361008 16371368 21706016 8041791 11085989 8978300 11432792 15882975 9362449 10212213 11684012 7523381 10592173 16189514 10747947 10973965 9632781 8959326 11602579 12577067 9254654 10080542 15010462 31585087 12531430 8995399 19380743 7522233 9804835 7534299 9824671 9660791
SRC GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 12624098 11964172 9016807 16713569 26103942 20554525
FRS2 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 8780727 9182757 12974390 11997436 16189514 12402043
GRB2 GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 47.0 1.0 Omnipath 12766170 21706016 9242692 10913131 11445578 22536782 8596638 11027663 10592173 20936779 11960376 15010462 19523899 20005866 19380743 10871282 9804835 14685170 11314042
GRB2 KHDRBS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 10467411 20936779 21988832 7537265 9872323 8576157 11960376 11278465 9045636 21706016 16713569 12112020 7799925
GRB2 SOS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 17145710 21988832 20936779 19531499 14764585 10940929 19380743 21706016 10359574 14679214 17474147 21779497 9199344 7629138
GRB2 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 9281317 15953601 7629168 9020117 16713569 10940929
GRB2 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17496910 16713569 17673906 11352655
LYN STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11413148 17081983 7925280 11641791 9573010 15212693 8617237
LYN MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11131153
LYN PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21780115 15032589 11526404 23109003 22880054 10488096
LYN PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 21780115 29145629 12506011 18453587 11526404 10455108 15032589 23109003 23180781 9334184 15149544 10194437 22880054 11598010 10488096
LYN SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23109003 7650013 7516469 10329689
LYN PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 45.0 1.0 Omnipath 17389395 12601080 8395016 16038803 10586033 1689310 20068231 1708307 7682059 8885868 15144186 16497976 8657103 15592455 16126727 17016520 16153436
LYN PTPN6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 35.0 1.0 Omnipath 19171907 11042209 8692915 14699166 22624718 19690332 12468540 10574931 17570479 18083107 14757045 8114715 10488096 28811476
NRAS MAPK1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
HRAS MAPK1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
MAPK1 IL17RD â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11802164 15239952 21779496 11802165 15260967
FGFR1 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
FGFR2 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
MAPK1 FRS2 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
MAPK1 FGF23 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
MAPK1 KLB â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
MAP2K1 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 149.0 1.0 Omnipath 21675959 9694850 17081983 10757792 11319218 18799465 15592455 12788955 19415658 12697810 17389395 9447970 15342917 8226933 15851026 12270934 12644307 17255949 10998418 11242034 1378617 1381507 17906627 11986622 8376945 8157000 7992057 11948414 9731057 19651622 11251083 11266467 18707149 14743221 11279118 11704645 12750173 12932319 16497976 11337027 23331499 12048245 7559390 17272394 15811950 19494114 18669648 18691976 11741894 15972258 19053285 16094384 17192257 7898932 24623782 9166761 19369195 21336309 12920017 15466214 17016520 19901323 1712480 19690332 11823456 9032297 11134045 12876277 19534553 10995751 20068231 21506533 8223433 8248196 16153436 12594221 10567369 19933846 17563371 11730323 29175850 11352917 16135787 15951569 19058874 15212693 23241949 9560161 91184134 18083107 16887817 18578522 17569879 21071413 9148935 18452278 1330321 8670897 19541618 10777511 15935618 12925710 11971971 9765155 11136732 11118451 12082107 12952943 10746662 21768338
SHC1 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10996427 23584453
MAPK1 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12975377 23602568 16424009 19058874 23397142 21707490
MAPK1 STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 9804779 25241761 18775330 10194762 8226933 10996427 9604935 8388392 12091337
MAPK1 CEBPB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 16009338 12213825 8384717 10995751 12048245 15878863 21980398 19443782 17570479 19413330 19723873 15367685
MAPK1 RPS6KA3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 21988832 18156174 12016217 25241761 12832467 23602568 8939914 10480933 9915826 17906627 10980595 10856237 19282669
MAPK1 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 25409419 11733495 16574647 9099735 9030579 15507114 26670611 17570479 17998334 18596912
MAPK1 RPS6KA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 60.0 1.0 Omnipath 17081983 32814053 20385094 11532940 7601337 23331499 15342917 8939914 21071413 23047924 20068231 11335727 9687510 12618428 18988627 18669648 23519423 23109003 18691976 12594221 9915826 17906627 8202512 9430688 19651622 12832467 11500364 14966081 29997244 25730857 8387505 10411321 18212344
MAPK1 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12801888
MAPK1 PGR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 8702648 17173941 18202149 10628747 15798179 17717077 12529413 15212693 10655479 11110801
MAPK1 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 27342992 23405013
MAPK1 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 59.0 1.0 Omnipath 18448488 19413330 11335711 9343414 15465816 25584415 12576423 11350938 20068231 12681450 12763138 9872331 11780390 18491316 18669648 11404481 10521505 18691976 20058876 15979846 14551213 10446219
MAPK1 CTTN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10537323 21079800 17570479 22514278 20444238
MAPK1 NFATC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15657420
MAPK1 GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 12008033 26538579 15379552 10593929
MAPK1 PTPRR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 26186194 16148006 25241761 10601328 10419510 9857190 18083107 11493009
MAPK1 KHDRBS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 18691976 12478298 19664995 20068231
MAPK1 TCF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 14592976 12810726
KRAS MAPK3 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
NRAS MAPK3 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
HRAS MAPK3 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
MAPK3 IL17RD â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11802164 15239952 21779496 11802165 15260967
FGFR1 MAPK3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
FGFR2 MAPK3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
MAPK3 FGF23 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
MAPK3 FRS2 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
MAPK3 KLB â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
MAP2K1 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 106.0 1.0 Omnipath 9694850 17081983 11319218 18799465 17389395 9447970 15342917 8226933 15851026 12270934 12644307 11242034 1381507 17906627 9677429 11986622 8376945 7992057 11948414 7687743 9731057 19197339 11704645 7565670 12750173 12932319 8626767 23331499 12048245 7559390 17272394 15811950 26987942 19494114 18669648 18691976 17192257 8388392 7898932 16464493 19369195 12920017 15466214 19690332 11134045 19534553 10995751 7867743 8223433 8248196 10567369 19933846 17563371 1518847 11730323 18983981 16186792 16135787 15951569 19058874 15212693 10748187 9560161 9925641 9733512 18083107 11104681 9006895 17569879 21071413 7731720 1330321 93330262 19541618 15466476 12925710 11971971 11136732 11118451 10746662
MAPK3 STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 9804779 20508164 23331499 24263804 18775330 10194762 12407017 8226933 17502367 34188118 9604935 18988627 31932645 8388392 12091337
MAPK3 CEBPB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 16009338 12213825 8384717 10995751 12048245 15878863 19327116 19443782 15212693 15367685
MAPK3 PTPRR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 10419510 9857190 18083107 11493009 10066421
MAPK3 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 73.0 1.0 Omnipath 18448488 19413330 11335711 9343414 23331499 15465816 25584415 12576423 11350938 20068231 12681450 10417333 12763138 9872331 18988627 11780390 18491316 18669648 11404481 10521505 18691976 19723038 20058876 14551213 10446219
MAPK3 NFATC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15657420
MAPK3 RPS6KA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 23331499 15342917 18039929 12832467 23109003 8387505 14966081 9915826 21071413 17906627 9430688 11335727 18988627 11532940 10411321
MAPK3 PGR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 12529413 10655479 10628747
MAPK3 RPS6KA3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 18156174 25241761 12832467 8939914 9915826 17906627 10980595 10856237 19282669
MAPK3 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 27342992 23405013 18411303
MAPK3 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 28115363 12801888
MAPK3 RUNX2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 27687725 19264160 29057206 25867060 19801668 25122769 21965325 25187572
MAPK3 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18596912 11733495
MAPK3 TCF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 14592976
MAPK3 GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12008033 15379552
MAPK3 CTTN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 10537323 17081983 18088087 15144186 21079800 16964243 20444238
NEDD4 PTEN â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 17218260 17218261 17996703 18562292 19652529 22679284
NEDD4 PTEN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17218261 23331499 21071413 18307411 17218260 18562292 18498243 19345329 19652529 30594392
RPS6KA3 NFATC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 15187187 21233202 17081983 18220336 16286006 15657420 15239952 17213202
NRAS PIK3R1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
KRAS PIK3R1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
PIK3R1 FGF23 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11353842 9632781 14534538 9182757
PIK3R1 KLB â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11353842 9632781 14534538 9182757
FLT4 PIK3R1 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
CRK PIK3R1 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
SHC1 PIK3R1 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
STAT3 PIK3R1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11733515 24218138 23963458 15793565 16293640
HRAS PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9069260 25241761 10212255 11313862 9150145 16713569 15021914
PTPN11 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 11593409 18950707 15790353 23109003 16371368 17722974 22315502 16107703 9660791 9918857 8080844 9632795 10973965
PPM1A PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15016818
PTEN PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16288286 10648629 17218262 12040186 15584861
GAB1 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 17145710 10978177 11940581 8596638 24728074 9891995 16638574 9658397 9804835 11606067 9632795
SHC1 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 19531499 8662998 7537361 19380743 8621719 16135792 9541596 16219545 16713569 23397142 19889638
FYN PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 8294442 8394019 7515100 17570479 16713569 7520528 1652056
PTPN6 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 21780115 11337495 11526404 15032589 9065461 11160222 23109003 22880054 10488096
CRK PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 10962563 35044719 25241761 19380743 12878163 25814554 11418612
FGFR1 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17496910 18412956 25241761 15117958
PIK3R1 CRK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 10962563 35044719 25241761 19380743 12878163 25814554 11418612
PRKDC POU2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 17213819 9368058 14612514
PTPN11 PTPN6 â—¼   PHYSICAL_INTERACTION 42.0 1.0 ACSN 10358138 11447289 11449354 11572860 12138178 12176909 1238444 12393695 12421919 12707331 12773515 12917349 15169881 15240681 15699106 15713798 16204085 17371980 19833085 20007250 20038811 20363967 20435894 21469115 22437870 22483603 22513334 22683124 22952938 22955274 23732914 25355530 26667266 26755705 26885856 27474009 27806234 28893624 8976179 8986721 9751747 9765283
PTPN11 PTPN6 â—¼   SHARES_COMPLEX 42.0 1.0 ACSN 10358138 11447289 11449354 11572860 12138178 12176909 1238444 12393695 12421919 12707331 12773515 12917349 15169881 15240681 15699106 15713798 16204085 17371980 19833085 20007250 20038811 20363967 20435894 21469115 22437870 22483603 22513334 22683124 22952938 22955274 23732914 25355530 26667266 26755705 26885856 27474009 27806234 28893624 8976179 8986721 9751747 9765283
FYN PTPN11 â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 10591186 10648627 12218089 12731048 19290918 19909365 20814939 21378271 22683124 22863785 24440149 27192565 9738502
FRS2 PTPN11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 23331499 10650943 9632781 11360177 11447289 29997244 12974390 16189514 25159185
FYN PTPN11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10212213 11157475 16713569
PTPN11 STAT5B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 10617656
PTPN11 GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 72.0 1.0 Omnipath 14701753 18577518 17145710 11453982 12582165 20308328 14665621 8596638 14982882 20473329 11027663 10592173 10788507 9658397 12024020 10068651 24728074 11134009 10194437 12855672 21442024 11323411 11940581 15574420 11278704 10871282 9804835 9632795
PTPN11 STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 23331499 10617656 18508557 12220225 16189514 12060651 12237455
PTPN11 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 10409724 23331499 18508557 12040451 16189514 11594781
PTPN11 PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 18950707 23109003 16371368 17722974 22315502 16107703 9660791 8080844 9632795 15790353
PTPN11 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 18757826 18482983 10698938 17974954 14687660 24632723 20308328
STAT3 STAT5B â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 23073628 15790786 11369651 15007386 12481435 15526160 28403213 10358045 28192400 17546049 9355737
STAT3 STAT5A â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 23073628 15790786 11369651 15007386 12481435 15526160 28403213 10358045 28192400 17546049 9355737
PTPN6 STAT3 â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 12176909 12773515 12917349 15240681 15713798 22513334 22952938 25355530 26667266 27474009 8976179 8986721 9765283
STAT3 MMP9 â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10347215 11875494 12193690 12223527 12907458 14607900 14670306 15218058 15356132 15465827 15573129 16418395 17404308 18776941 19380816 20093776 20237412 20406969 20435894 20580461 20581311 21372296 21765015 21840487 22461508 23124025 23390297 23454751 23953057 24857661 27216177 28186502 7543512
STAT3 CEBPB â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10347215 11875494 12193690 12223527 12907458 14607900 14670306 15218058 15356132 15465827 15573129 16418395 17404308 18776941 19380816 20093776 20237412 20406969 20435894 20580461 20581311 21372296 21765015 21840487 22461508 23124025 23390297 23454751 23953057 24857661 27216177 28186502 7543512
STAT3 TIMP1 â—¼   UP_REGULATES ✅ + 38.0 1.0 ACSN 10347215 11528470 12223527 13130303 14607900 14670306 15218058 15356132 15573129 15810077 16418395 16716598 16831886 17403902 18297062 18776941 18832382 19380816 19412634 20093776 20237412 20406969 20581311 21317430 21840487 21883379 22006115 22943793 22945800 23124025 23454751 23953057 24857661 27216177 28186502 7543512 7768934 9278421
STAT3 TIMP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15920698 8559663 16931573 24036113 15161657 11918744
PRKCE STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 24703937 21406403 17875724 20350291 19567682 21480396 20228845 27102301 17583567 16418226
MAP2K1 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9305919 7719937 7568001 10602027 12681450 7719938 7544001 7528668
SRC STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 88.0 1.0 Omnipath 19901323 10918587 9305919 8272872 29036202 9344858 12626508 10815799 16497976 15592455 16713569 17389395 12576423 11350938 9484840 11294897 28978186 18070987 12244095 27472461 21690253 23928694 22303479 8657134 11404481 9083098 14963038 8626374 17016520 9566874 10982829 15212693 11940572 11429593 14551213 15037656 15313931 11850821 9154828 9582023
CEBPB STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11134330 18266962
PKM STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 23791887 29127353 22901803 22306293 24115444 28978186 27080861 26542452
FGF10 FGFR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 17145710 23331499 25241761 21071413 16597617 9582367 10339576 12591959 8663044 25772309
E2F4 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15711575 15895078 12110166
E2F4 E2F2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17531812 21247883 9149906 15718499
ITGA5 SHC1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 19342448 21844907 10714768 8598224
SHC1 CRK â—¼   PHYSICAL_INTERACTION 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
SHC1 FGF23 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9045692 9480847 18840094 7559490
SHC1 KLB â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9045692 9480847 18840094 7559490
SHC1 FLT4 â—¼   PHYSICAL_INTERACTION 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
SHC1 CRK â—¼   SHARES_COMPLEX 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
SHC1 FLT4 â—¼   SHARES_COMPLEX 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
SHC1 FLT4 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
SHC1 PLCG1 â—¼   ENZYMATIC_REACTION ✅ 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
SHC1 FYN â—¼   DOWN_REGULATES ✅ - 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
FLT4 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 9388490 7675451 9096689 15592455 9121430 9446569 10891441 11687594 23331499 10921922 10482988 10764799 12522270 9685404 10896916 9927207 8662748 8702728 12237775 8610109 9741627 9710204 10816433 11075717
FYN SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 96.0 1.0 Omnipath 19901323 20230923 16497976 9121430 15592455 16713569 9446569 17389395 23331499 18578522 10921922 10482988 10764799 18452278 20068231 10592173 18669648 12522270 9685404 10896916 7516469 9927207 12237775 8702728 8610109 19651622 9741627 9710204 19664994 17016520 10816433 11075717
SRC SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 55.0 1.0 Omnipath 19901323 9388490 8939605 9096689 10971656 16497976 15592455 9121430 10891441 17389395 11687594 10329689 10482988 20068231 17570479 16189514 9685404 23109003 7516469 9927207 18840094 15688026 15212693 1409579 14963047 9710204 26551075 17016520 11075717
SHC1 GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 11707404 14982882 24728074 10871282 10194437 9804835 12808090
CRK FLT4 â—¼   PHYSICAL_INTERACTION 56.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11335727 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15308668 15501236 15520864 15567848 15573129 15574420 16000375 16002046 16076871 16530705 16572188 16582911 16887996 17086423 17496910 17673906 17883421 18835194 19414323 19449109 19454690 21372296 22064427 22461508 22464172 23390297 24217602 24346288 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
CRK FLT4 â—¼   SHARES_COMPLEX 56.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11335727 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15308668 15501236 15520864 15567848 15573129 15574420 16000375 16002046 16076871 16530705 16572188 16582911 16887996 17086423 17496910 17673906 17883421 18835194 19414323 19449109 19454690 21372296 22064427 22461508 22464172 23390297 24217602 24346288 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
CRK FLT4 â—¼   ENZYMATIC_REACTION ✅ 56.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11335727 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15308668 15501236 15520864 15567848 15573129 15574420 16000375 16002046 16076871 16530705 16572188 16582911 16887996 17086423 17496910 17673906 17883421 18835194 19414323 19449109 19454690 21372296 22064427 22461508 22464172 23390297 24217602 24346288 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
CRK GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 24728074 20619534 12138161 19380743 11146548 10592173 19350053 16713569 10618718
CRK PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 35044719 19380743 25814554 11418612
PDGFB PDGFA â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9334164 10508235 1311092 8900172
PDGFB SPP1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9334164 10508235 1311092 8900172
PDGFB SRC â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 7685273 9488729 10508235 9739761
PLCG1 SRC â—¼   PHYSICAL_INTERACTION 36.0 1.0 ACSN 10072481 10781611 10811803 10925299 11169415 11476890 11532940 11994416 12040186 1281218 12845332 14585353 14764585 15214048 16488589 16919435 1712101 17397400 17496910 17517963 19568798 19909365 23523669 24584707 2536067 25456276 25572304 25960930 26552706 27216177 7682895 7890616 8226994 8649391 9535722 9846483
PLCG1 SRC â—¼   SHARES_COMPLEX 36.0 1.0 ACSN 10072481 10781611 10811803 10925299 11169415 11476890 11532940 11994416 12040186 1281218 12845332 14585353 14764585 15214048 16488589 16919435 1712101 17397400 17496910 17517963 19568798 19909365 23523669 24584707 2536067 25456276 25572304 25960930 26552706 27216177 7682895 7890616 8226994 8649391 9535722 9846483
FGFR2 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 12601080 17081983 7999363 16038803 1689310 1708307 7682059 15144186 8885868 16126727 15592455 8657103 16153436 24440983
SRC PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 43.0 1.0 Omnipath 8388373 16497976 16126727 16713569 17389395 1689310 20068231 17570479 16153436 16038803 1708307 7682059 7510703 18594017 12601080 8885868 8657103 17016520
FYN PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8395016 10586033 7682059 16713569
GAB1 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 8596638 23331499 11507676 24728074 10871282
FGFR1 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 17081983 20932831 1656221 16126727 15592455 9660748 19665973 7991458 1689310 8321198 8050374 16153436 17496910 25241761 16038803 10459043 23063561 1708307 7682059 15144186 12601080 9052794 8885868 8657103 15212693
SRC PTPN6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 8692915 17675340 14551136 25535246 14699166 12468540 10574931 16649996 8647855 7512963 9261115 34010642 14757045 12468645 8114715 15212693 10488096 21900501
PTPN6 PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 21780115 15032589 11526404 23109003 9065461 22880054 10488096
ITGA5 FYN â—¼   ENZYMATIC_REACTION ✅ 14.0 1.0 ACSN 12731048 18037882 19161977 19454690 19487819 20644254 20814939 22067905 22470492 24202395 9003039 9456329 9763606 9973479
EPHA4 FYN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12084815 23331499 16713569
FYN PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 7515100 1334406 16713569 1652056
FYN RPS6KA3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18156174 12601080
FYN ITCH â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 16387660 17053785
SMAD4 SPP1 â—¼   PHYSICAL_INTERACTION 47.0 1.0 ACSN 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 8515656 9312026 9389648 9618481 9670020
SMAD4 SPP1 â—¼   SHARES_COMPLEX 47.0 1.0 ACSN 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 8515656 9312026 9389648 9618481 9670020
SMAD4 TIMP1 â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 8515656 9389648
SMAD4 SPP1 â—¼   ENZYMATIC_REACTION ✅ 47.0 1.0 ACSN 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 8515656 9312026 9389648 9618481 9670020
SMAD4 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21836474 21926264 16580992 12524424
EGF PLAU â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 12094222 15003992 15175028 15466195 15958574 18423981 19631971 20430953 21098712 8101258
PPARG MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20021931 22472882 22207709 9665460
PTEN GAB1 â—¼   REGULATES ✅ 15.0 1.0 ACSN 10648629 10753747 11747822 12040186 15584861 15721744 16288286 16982858 17218262 19847259 22179046 22465479 23732914 24254977 25364523
PPARG PTEN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18065496 16775433 16425225 23867870 20198337 11378386
SRC PTEN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 24830552 22891331 12869565 21532586
PTEN PIK3CG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16288286 10648629 17218262 12040186 15584861
PIK3R2 HRAS â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
HRAS FGFR1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
HRAS FRS2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
SOS2 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17496910 12628188 17673906 21779497
SRC HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 12695509 9626657 9020108 25157176 33413561
HRAS PIK3CG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9069260 9727023 17145710 10922060 11136978 21779497
SMURF1 RUNX2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17145710 14701828 16299379 12738770
CEBPB PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 22473998 23934183 7557387 12524424 16431920 22610404 15110775 18694725 17242167 16054042 15158467 9950217 10862621 20829347
PPARG RUNX2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12878983 18715135 20589837 12704187
SRC PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 30323259 10322133 26385316
SPP1 ITGA5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 7592829 16713569
SRC FLT4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 16076871 12881528 20431062 18083107
PDGFA SRC â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 7685273 9488729 10508235 9739761
PRKCE SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 17496910 11940581 21386996 11447289 19615955 11834516 16488589 6321473 8321321 12845332 11313945 12040186 19568798 15567848 14585353
EGF SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23349873 19481075 15845350 22927910 27462789
SRC PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21780115 15032589 11526404 23109003 22880054 10488096
SRC GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 26706435 15574420 19881549 12941962 21442024 12808090
SRC STAT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 11413148 17081983 10358079 22090359 7925280 16189514 15702476 11641791 15212693 8617237
SRC CTTN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 70.0 1.0 Omnipath 27603901 22823952 7680654 9748248 28522963 19419567 19690332 16497976 15592455 19413330 25077552 17389395 19534553 20068231 28769876 17570479 20708589 19273217 18491316 18669648 16162656 25682866 12522270 18088087 22761768 26142315 17287340 27009365 10921917 9683637 24465712 27758765 24675741 12601080 18707149 16212419 15169891 7519605 17016520 11389697
SRC STAT5B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 19438593 12429742 17997837 12621061
SRC RPS6KA3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18156174 12601080
SRC KHDRBS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 9038356 10467411 8766817 22745667 7537265 7516469 11960376 10635328 1374686 18606683 16169070 16713569 1545818 15190072
PDGFA SPP1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 9334164 10508235 1311092 8900172
RUNX2 SPP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 18410224 19903460 20713445 14506237 19259985 19915614 21455926 23644099 9794229 11331591 16670084 16195230 19649655
FGF1 FGFR1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 14517404 16272825 16682805 26183471 9242465
FGF1 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 49.0 1.0 Omnipath 16597617 8756477 1383494 8576175 9624181 1722683 11714710 23331499 21071413 14613973 10830168 16189514 23597563 25241761 22244757 7730326 25772309 1309595 18441324 18940940 11032250 10336501 11030354 8663044
FGF1 FGFR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 17145710 10618369 11714710 23331499 25241761 21071413 11069186 16597617 8576175 10339576 8663044 23597563 14732692 25772309
FGF3 FGFR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23331499 75926248663044 16597617 8663044 7592624 25772309
GAB1 FRS2 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 17505008 18757403 21666749 11689702 11739186 18381441 19809159 21160078 14534538 15448205
FGFR1 FRS2 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 12767520 17496910 17673906 25467007
KRAS FRS2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
NRAS FRS2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
FGFR2 FRS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 17496910 15574420 11447289 14585353 11777939 16488589 11997436 6321473 9182757 12040186 19568798 15567848 15173823 11274345
FGFR1 FRS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 29.0 1.0 Omnipath 11447289 11777939 11997436 11877385 12040186 9660748 15173823 25394172 23331499 6321473 16189514 19568798 14585353 17496910 9632781 10629055 21765395 11274345 15574420 9182757 11090629 15567848 16488589
FGFR1 FGF23 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 1379698 16507368 8622701 11294897 17086194
KRAS FGFR1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
NRAS FGFR1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
FGF23 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 27879395 19966287 16597617 16081635 22393163 25772309
FGF5 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 16597617 83868288386828 8386828 25772309
PRKCE FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 17496910 11940581 21386996 11447289 19615955 16488589 6321473 8321321 12845332 11313945 23564461 12040186 19568798 15567848 14585353
FGFR1 CTTN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 12601080 15592455 15951569
FGFR1 PIK3R2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17496910 15117958
STAT5B IGF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 16141355 20378540 17509524 20372799 11517160 12682066 22419735 24914937 20702579 14532269 20139685 15677453 18276757
STAT5A IGF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 20378540 19920132 17509524 10050749 20372799 21651786 23071812 14532269 15677453 18276757
FGFR2 GAB1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11353842 9632781 14534538 9182757
FGF5 FGFR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 838682811876253 16597617 8386828 11876253 25772309
FGF23 FGFR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 16597617 16081635 12032146 1608163512032140
PRKCE FGFR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 17496910 11940581 21386996 11447289 19615955 16488589 6321473 8321321 12845332 11313945 23564461 12040186 19568798 15567848 14585353
FGF6 FGFR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 16597617 25772309 8663044
FGF8 FGFR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 23331499 10751172 16597617 8663044 25772309
USP8 RNF41 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15314180 23750007 17035239
CEBPB KRAS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11500490 18444174 16107878 10318842
CEBPB BGLAP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15713650 16772287 16720721 18843047 11668178
CEBPB INS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9353292 21063109 19164449 10649437
USP8 STAM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16520378 10982817 20736164
KRAS MAP2K1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
NRAS MAP2K1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
MAP2K1 IL17RD â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11802164 15239952 21779496 11802165 15260967
KRAS PIK3CG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9727023 16189514 10542052 21779497
GAB1 KLB â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11353842 9632781 14534538 9182757
GAB1 FGF23 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11353842 9632781 14534538 9182757
PIK3R2 KRAS â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
PIK3R2 NRAS â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235