Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
EGFR NRAS â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
EGFR KRAS â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
EGFR HRAS â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
EGFR HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 17673906
PTPN11 KRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 26617336
PTPN11 NRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 26617336
PTPN11 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 26617336
PLK4 SFN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
SFN PLK4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
HRAS RALBP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
YWHAB LSR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
YWHAG LSR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
ITSN1 EPS15 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5211195 10064583
STON2 EPS15L1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6179743 18200045
ESR1 YWHAQ â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22329840
ESR1 EPHB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17685427 20484412
REPS1 STON2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6179743 18200045
H2BC9 LSR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H2BC9 NRG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
YWHAB YWHAG â—¼   PHYSICAL_INTERACTION 801.0 0.8 STRING 36370105
ESR1 YWHAB â—¼   PHYSICAL_INTERACTION 818.0 0.81 STRING 36370105
PTPN11 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 16729043 5218694
RHOB EGFR â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
EGFR AP1B1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 24797263 24189400
AP1B1 AP2A2 â—¼   PHYSICAL_INTERACTION 819.0 0.82 STRING 36370105
LSR AP1B1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
AP2A2 AP1B1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33961781 26344197
RHOB ROR2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
LSR AP2A2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
LSR EPS15 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
LSR VPS45 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
RHOB VPS45 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
ESR1 VPS45 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 19805454 31527615
ESR1 1433E â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 19805454 31527615
1433G PLK4 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
1433F PLK4 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
1433T PLK4 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
1433B PLK4 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
LSR SMAD5 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
LSR RBP1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
LSR ITSN1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
LSR STON2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
RHOB STON2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
1433E LSR â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17979178 31980649
EPHA7 EPHA4 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
LSR REPS1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
CLC2D LSR â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
GGT7 LSR â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
PCDC2 LSR â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
GP114 LSR â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
1433T LSR â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
RHOB LSR â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
ADA33 LSR â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
LSR EP15R â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
RHOB EPHA7 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
EPS15 AP1B1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 12538641 33961781 19380743
EPHA4 FGFR1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 16365308 18790757
SPIT2 LSR â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
NRG1 LSR â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
SYNE4 LSR â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
IL9R LSR â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
CC50A LSR â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
STON2 EPS15 â—¼   PHYSICAL_INTERACTION ✅ 0.84 0.84 mint 6179743 18200045
EPS15 STON2 â—¼   COLOCALIZATION ✅ 0.84 0.84 mint 6179743 18200045
KRAS NRAS â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
EGFR AP2A2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 24797263 8548289 24189400 23956138 31959764
EPS15L1 ITSN1 â—¼   PHYSICAL_INTERACTION 862.0 0.86 STRING 36370105
PTPN11 EGFR â—¼   DEPHOSPHORYLATION ✅ - 0.86 0.86 Signor 12582165
EGFR NTRK2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 24658140 25402006 31980649
EGFR 1433B â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 24658140 25402006 31980649
1433F LSR â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 17979178 33961781
HRAS NRAS â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
EGFR SFN â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
ESR1 EGFR â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16713569 28065597 20935677 11887937 17284441
YWHAE YWHAG â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
YWHAE YWHAH â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
EGFR EPS15 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
YWHAB YWHAE â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
YWHAG YWHAH â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
YWHAB YWHAH â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
1433T ESR1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11266503 33731348 31527615
ESR1 MED23 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11867769 31527615
1433B LSR â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 17353931 33961781 15324660
LSR 1433G â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 17353931 33961781 15324660
1433G 1433F â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 17979178 26496610 22863883 33961781 15324660 26344197
1433G 1433T â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 17085597 20618440 22863883 33961781 15324660
ITSN1 EP15R â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 32203420 33961781 22558309 26344197
STON2 EP15R â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 33961781 18200045 11381094
1433T 1433E â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 31980649 21988832 17979178 17085597 20618440 33961781 20936779
1433E 1433F â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 31980649 31536960 17979178 26496610 22863883 33961781 20936779 7615088 12507503 26344197
1433F 1433T â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 17979178 26496610 20618440 22863883 33961781
HRAS KRAS â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
EGFR NRG1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 7730382 25402006 31980649 24658140
EGFR 1433T â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 20029029 31980649 24189400 24658140 25402006 15657067
YWHAG SFN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15778465 15324660
SFN YWHAG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15778465 15324660
APOC1 APOC4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 21776394 11353333 12700345
APOC1 LSR â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10224102 15265030 18644789
YWHAG YWHAB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17085597 15324660
YWHAB YWHAG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17085597 15324660
STON2 EPS15 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 18200045 19380743 11381094
ESR1 CLDN4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20034404
1433E 1433G â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 31980649 21988832 31536960 17979178 17085597 33961781 20936779 12507503 26344197
RBP1 REPS1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 9395447 31980649 33961781 23414517 32203420 26344197
EPHB2 ITSN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 12389031
APOC4 LSR â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10224102 15265030 18644789
AP2A2 EPS15 â—¼   PHYSICAL_INTERACTION 902.0 0.9 STRING 36370105
EPS15 ITSN1 â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
EGFR PTPN11 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
EGFR EPS15 â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 32377695 15701692 16499958 21226813 19109251 10953014 9049247 16429130
RALBP1 REPS1 â—¼   PHYSICAL_INTERACTION 952.0 0.95 STRING 36370105
EPS15 STON2 â—¼   PHYSICAL_INTERACTION 952.0 0.95 STRING 36370105
EPS15 ITSN1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 10922467 22558309 32203420 26344197 10064583
1433F 1433B â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 17979178 26496610 33961781 24255178 26344197
1433G 1433B â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 17085597 33961781 24981860 24255178 15324660 26344197
1433T 1433B â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 17085597 20618440 22863883 33961781 24255178
1433B 1433E â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 31980649 31536960 17979178 17085597 33961781 24255178 20936779 12507503 30135474 26344197
EPS15 AP2A2 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 26822536 18362181 10809762 19380743 8662627 9049247
ESR1 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12894229 12421825 8200909 21705183
PTPN11 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 34.0 1.0 Omnipath 28065597 9756944 7588774 16273093 14560030 9642214 8197172 15618223 12270932 7673163 12582165 10411909 16729043 11223155 12577067
EGFR ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 20809984 17284441 16713569 11887937
EGFR EPS15 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 17145710 17389395 10953014 24269888 19534553 25260758 19583965 19690332 15951569 9049247 17016520
SFN YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21827211 12657644 12426317 15071501
HRAS YWHAB â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 10358164 11532940 12566895 14764585 15516985 16102570 19289794 19565474 24027568 7510700 8551221 9069260 9763606 9846483
HRAS YWHAB â—¼   SHARES_COMPLEX 14.0 1.0 ACSN 10358164 11532940 12566895 14764585 15516985 16102570 19289794 19565474 24027568 7510700 8551221 9069260 9763606 9846483
HRAS FGFR1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
HRAS FGFR4 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
HRAS NRG1 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 Reactome 23220880 25853726 30301790 28274957 18039657 16843263 25994018 26545934 22046346 18413839 23948973 26375550
KRAS YWHAB â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 12068308 23352452 25907612 15035987
NRAS YWHAB â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 12068308 23352452 25907612 15035987
YWHAE YWHAB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 20936779 17085597 12507503 24255178 17979178
YWHAB YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17085597 12657644 12426317 15071501
YWHAB YWHAE â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 20936779 17085597 12507503 24255178 17979178
KRAS FGFR1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
NRAS FGFR1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
YWHAE YWHAG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 21988832 20936779 17085597 12507503 17979178
YWHAG YWHAE â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 21988832 20936779 17085597 12507503 17979178
YWHAG YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17085597 21827211 12426317 15324660 15071501 12657644
YWHAH YWHAE â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 20936779 12507503 7615088 26496610 17979178
YWHAE YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 21988832 20936779 20618440 17085597 21827211 12426317 15071501 12657644 17979178
YWHAE YWHAH â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 20936779 12507503 7615088 26496610 17979178
YWHAH YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21827211 12657644 12426317 15071501
KRAS NRG1 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 Reactome 23220880 25853726 30301790 28274957 18039657 16843263 25994018 26545934 22046346 18413839 23948973 26375550
KRAS FGFR4 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
NRAS NRG1 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 Reactome 23220880 25853726 30301790 28274957 18039657 16843263 25994018 26545934 22046346 18413839 23948973 26375550
NRAS FGFR4 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196