Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
ABL1 CDC42 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10601328 19564926
ABL1 FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
CSF1R CBL â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8981370 20489731
FYN CBL â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 5220480 7642581
SHC1 CBL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5220991 8621719
LCP2 CBL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6548125 9716598
FYN CBL â—¼   PHOSPHORYLATION ✅ 0.8 0.8 mint 5217342 15556646
CBL FYN â—¼   PHOSPHORYLATION ✅ 0.8 0.8 mint 5217342 15556646
CBL SRC â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5219404 17141222
CBL MET â—¼   UBIQUITINATION ✅ 2.0 0.8 intact 5215187 11894096
CBL ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
IRS1 EGFR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
JAK2 EGFR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
GRB10 EGFR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6547677 9506989
EGFR CRKL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16729043 5218694
EGFR IRS4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
JAK2 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9209406 8400282
FYN GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9694876 7737275
LCK GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9694876 7737275
GRB10 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
GRB2 ERBB3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16729043 5218694
GRB2 CBLB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 GAB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5212828 10913131
GRB2 ELK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
GRB2 TPX2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
GRB2 CBLB â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
FGFR1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9480847 16713569
CRK TPX2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
EPOR CRKL â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11443118 11124936
JAK2 CRKL â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11443118 11124936
CRKL ERBB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
CRKL ERBB3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
CRKL SOS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9209406 8400282
CRKL IRS2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11443118 11124936
SRC LCP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6546918 15929943
SHC1 LCP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6548125 9716598
LCP2 FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6546918 15929943
SOS1 SHC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 9544989 6547749
SRC SHC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10964917 8755247
CD3E SHC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6731413 11855827
LAT SHC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10811803 8663278
SHC1 FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7516469 5220322
SHC1 ERBB3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16729043 5218694
SHC1 GAB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10704825 5212298
SHC1 INSR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6805769 9593725
FGFR1 SHC1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 17496910 25467007
IRS2 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11505033 15705774
EPOR SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16713569 8400282
ERBB2 CRK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
GHR CRK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ERBB3 CRK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
BCR CRK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8978305 21602891
LCK CD28 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8946678 9973466
LCK FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8946678 9973466
LCK CD3E â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CBLB LCK â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 8083187 11904433
FYN LCK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17570479 22043010
SOS1 FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
SRC FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219079 16966330
FYN CD28 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8946678 9973466
FYN AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
FYN CDC42 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11817894 15788770
FYN CSF1R â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6730431 7681396
ERBB3 JAK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
SOCS1 JAK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10421843 6731094
JAK2 IRS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15316008 17565041
JAK2 SOS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9209406 8400282
SRC JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17570479 17158356
ERBB3 JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16273093
JAK2 IRS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15316008 12960006
KIT GAB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16873377 18697750
ESR1 RAC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21118977 11060289
SOS1 SRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
SRC ERBB3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
SRC TLR3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218855 16858407
SRC ERBB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6731430 11940572
SRC CDC42 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11817894 15788770
SRC CBLB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17094785 7033811
TLR3 SRC â—¼   COLOCALIZATION 2.0 0.8 intact 5218855 16858407
CD28 CBLB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12193687 23109003
CBLB MET â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBLB ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBLB IGF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
ERBB3 FGFR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
NTRK1 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11147812
IRS1 IRS4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 11912194
IRS2 IGF1R â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8662806 5221055
IGF1R GRB10 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6547677 9506989
ERBB3 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 17308105
ERBB2 SOCS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
SOS1 IRS2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9209406 8400282
RHOB INSR â—¼   COLOCALIZATION 2.0 0.8 intact 14722096 6672086
RET GRB10 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7665556 8631863
ERBB2 IRS4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
ERBB2 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11173924 16713569
SOS1 GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11707404
GAB1 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11707404
EPOR SOS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9209406 8400282
CRK GRB2 â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
EGFR JAK2 â—¼   PHYSICAL_INTERACTION 807.0 0.8 STRING 36370105
GRB2 MET â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
KIT CBL â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 8950973 16780420 25737303 15315962
SHC1 FGFR1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 16189514 16713569 7514169 7559490 18022941
FGFR1 CRK â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 10464310 25241761
LCK CD3E â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 14523017 11855827
PGFRB FYN â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 1696179 16189514 16713569 7687537 9425276 7520528 7685273 1661130
GRB2 RET â—¼   PHYSICAL_INTERACTION 818.0 0.81 STRING 36370105
NTRK1 CBL â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 25921289 21570973
P85A CTLA4 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 9398332 7807015 9813138
IRS4 EGFR â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 24797263 16273093
RHOB EGFR â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
EGFR IGF1R â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17047074 17307140
RAC1 GRB2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 31980649
ADA12 GRB2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 25825872 11127814
GRB2 1433G â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31980649 21706016
CTNB1 LZTS2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 27684187
LCK LZTS2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 25416956
1433G LZTS2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
LZTS2 P85A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33420362 29395067
RHOB NISCH â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
P55G NISCH â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
HAVR2 NISCH â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
NISCH P85A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 32203420 27173435
TPX2 P85A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17474147 32203420
CRKL SOCS1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 25814554 29991678
SHC1 ERBB2 â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 16729043 5218694
INSR SHC1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 9121430 10482988 8702728 7559507 12237775 9446569 11075717 9710204 10803466 10896916 9741627 10921922 9593725 10816433 9083103 15629149 7499194 10764799
CRK PK3CB â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31980649 19380743
CUL3 P85A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 27708159 21145461
RHOB SRC â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
SRC PTN11 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 14687660 8959326 20308328
SRC P55G â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22402981 25814554
RASH CDC42 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 30194290 30442762
IGF1R CTNB1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 27684187 22261717
IGF1R ERBB2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17307140 30898150
UFO SOCS1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 29991678 12470648
P85A GRB10 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 12783867 23246379
PGFRB ERBB2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 7531698 30898150
NTRK1 PTN6 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 29715200 15557341
RHOB BCR â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
SOS1 BCR â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 8112292 7529874
P85A RET â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 32062451 10995764 10652352
MET ERBB3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 25326665 21918175
RHOB P85B â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
RN19B P85B â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
IRS4 P85B â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33961781 25036637
FLRT1 P85B â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
HAVR2 P85B â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
RHOB P85A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
SNX32 P85A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
P55G P85A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
DP13A P85A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 12621049 25814554
DEF5 P85A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
RN19B P85A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
FLRT1 P85A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
I20RA P85A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
P85A SHIP1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 9918857 12506011
P85A TGON2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17474147 29568061
FAK1 PK3CA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22402981 10733346
SH3K1 PGFRB â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 12177062 16189514
VAV PGFRB â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22974441 10938113
I20RA PK3CB â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
HAVR2 PK3CB â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
FLRT1 PK3CB â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
RN19B PK3CB â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
RHOB IRS4 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
IRS4 P55G â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33961781 25036637
HAVR2 P55G â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
FLRT1 P55G â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
I20RA PK3CA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
HAVR2 PK3CA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
FLRT1 PK3CA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
DEF5 PK3CA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
RN19B PK3CA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
SHC1 ABL1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 8112292 19380743 10194451
MK08 CBL â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 16982329 11944898
CBL PK3CB â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 14530346 19380743 33864160
CBL BCR â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 8621719 14725908 20675402 8641358 19380743
GRB2 PK3CA â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 9565634 21706016 32814053 33961781 19380743
GRB2 PK3CB â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 21706016
PCBP1 PK3CB â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
PCBP1 P85A â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
PCBP1 MET â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
PCBP1 PK3CA â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
P85A ELK3 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 17474147 25416956
LCP2 SHC1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 9716598 16189514
P85B SHC1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 19380743 8662998
SHC1 EPOR â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 16713569 8400282
LAT FCG2A â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 16189514 10781611
INSR JAK2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 12456798 8912646
FAK1 JAK2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 10925297 9553131
BCR KIT â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 8757502 25241761
KIT CBLB â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 12177062 15315962
SRC UFO â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 9178760 16189514
PTN6 GAB2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 11812650 11895767
GAB2 1433G â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 19172738
ICOS P85A â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 18641334 27135603
TGFR2 FGFR1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
IRS2 NTRK1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 25921289 11147812
GRB10 1433G â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 32814053 33961781
TGFR2 ERBB2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
SH3K1 SOS1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 11071869 16713569
VAV EPOR â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 9162069 16713569
P85B P85A â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194 19380743 32203420
P85B P55G â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 26186194 33961781 19380743
TGFR1 P85A â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 15657037 9435577
VSIG4 P85A â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
PK3CA PTN11 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 9660791 9565634 26839216
FCG2A PTN11 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
KHDR1 SH3K1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 31413325 22745667 19531213
TGFR2 PK3CB â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
1433G IRS4 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 15324660 25036637
IRS4 PK3CA â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 33961781 11912194
TGFR2 P55G â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
CTNB1 MET â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 11254878 11929826
EGFR GRB10 â—¼   PHYSICAL_INTERACTION 833.0 0.83 STRING 36370105
GAB2 SHC1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
CBL LCP2 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
ABL1 EGFR â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
SRC CBL â—¼   PHYSICAL_INTERACTION ✅ 0.84 0.84 mint 6538879 18273061
1433G CBL â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 28514442 33961781 15324660 11697890
PTN11 CBL â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 17330819 18519587 11157475
SRC CBL â—¼   PHOSPHORYLATION ✅ 0.84 0.84 mint 5219404 17141222
LCK CTLA4 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 9712716 9973379
PGFRB EGFR â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 9506992 7531698 16713569
GRB2 IRS2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 7559579 22974441 9852124 21706016
LAT LCP2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 24584089 16189514 9489702 23514740
LCP2 WASP â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 10747096 16189514
LCP2 KSYK â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 15388330 16189514 22267732
CBLB SHC1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 9614102 16189514
SHC1 DOK1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 11071635 22974441 10822173
SHC1 PGFRB â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 16189514 16713569 8195171
CRK SRC â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 23397142 10962563 12615911
HAVR2 LCK â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 22863785 26492563
PTN11 FYN â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 16189514 11157475 16713569 10212213
P85A IL1R1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 7499252 10373529 9360994
FGFR1 CTNB1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 18302981 11401320 25241761
P85B IRS1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 7559478 30240640 11120660 23604317 12730242
AKT1 IRS1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 10497255 17640984
SOCS1 IGF1R â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 32700452 9727029 29991678
ESR1 IGF1R â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 10749889 24051437 14764897 28555617 16113100
PK3CA AKT1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 21041639 19117013 21816939 25793261
IRS2 SOCS1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 27507812 29991678 12228220
SOCS1 INSR â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 11342531 15169905 29991678
SOCS1 P85A â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 10022833 25814554 29991678
INSR KHDR1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 10437794 11604231
ERBB2 PTN6 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 22973453 28065597
DOK1 P85A â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 11071635 22974441
PTN6 BCR â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 27432908 9788431 9211920
BCR 1433G â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 28514442 16045749 29100370 33961781
GAB1 RET â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 11360177 19914172 32062451
CSF1R SOS1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 10025673 7520523
SOS1 P85A â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 17474147 10025673 25241761
FAK1 KSYK â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 16189514 9342235 9169439
IRS4 P85A â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 33961781 25036637 18165436 11912194
MK08 P85A â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 7642542 16982329 25284480
RET SHC1 â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
ABL1 PTN6 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 10488096 8692915 7512963 10574931 8114715 12468540
CBL ERBB2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 26716506 12574167 25081058
CBL PK3CA â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 8641358 11157475 19380743 9119889
SRC GRB2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 16189514 16713569 11964172 9016807 12624098
KSYK GRB2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 16189514 22267732 11964172 10747947
CRKL WASP â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 11313252
CRKL SOS1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 9162067 26496610 33961781 32203420 23397142
LCK LCP2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 16354835 8702662 10556826 21725281
KHDR1 CRK â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 7537265 11278465 1545818
CRK BCR â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 8943292 8978305 19380743
KIT JAK2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 8611693 7527392 9355737
SRC ESR1 â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 17284441 6169640
KSYK SRC â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 7513017 16189514 9389695 15173175
SRC DOK1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 11071635 22974441
SRC GRB10 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 32814053 10871840 33961781
KSYK CBLB â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 12771181 10022120 16189514 27428901
CBLB P85A â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 11526404 10022120 9614102 19190244 10086340
SOCS1 IRS1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 17276034 11208867 29991678 12228220
INSR PTN6 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 12468540 8114715 7512963 8692915
FAK1 ERBB2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 21034468 25241761 16713569 12600989 11807823
P85A BCR â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 16219545 8781408 18346204
CD3E P85A â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 11689561 11855827 9312149 19190244
P85A CSF1R â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 8947469 10025673 25241761
PTN11 EPOR â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 7534299 8639815
MET P85A â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 24728074 7513258
SHIP1 PTN11 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 11453982 9110989 11157475
ERBB2 GRB2 â—¼   RELOCALIZATION ✅ + 0.85 0.85 Signor 14967450
IGF1R INSR â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
IGF1R IRS1 â—¼   PHOSPHORYLATION ✅ + 0.85 0.85 Signor 17827393
KIT ABL1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 12374739 24728074
ABL1 ERBB2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 22973453 16273093 19275932
MET CBL â—¼   PHYSICAL_INTERACTION ✅ 0.86 0.86 mint 6538879 18273061
MET CBL â—¼   UBIQUITINATION ✅ 0.86 0.86 mint 11894096 5215187
SOCS1 EGFR â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 22973453 29991678 12070153
PK3CA EGFR â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 28628118 25754235 1845983 8561895 28205554 31959764
IRS4 GRB2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 21706016 9553137
GRB2 P55G â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 32296183 21706016
P85B CRKL â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 9092574 11553620
CRK SHC1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 8035825 9837978 9461587 9617486 19380743 10464310 23397142
SH3K1 CRK â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 11071869 31980649
CRK P55G â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 19380743 25814554
SOCS1 KIT â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 10022833 29991678
AKT1 P85A â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16007092 10527852 19117013 28628118 28205554
AKT1 DP13A â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 29523594 25241761 12621049 25814554
P85A CD19 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 15187135 7684160 7528218
VAV CD19 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 15187135 16289966 7528218
TLR3 P85A â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 15502848 16858407
CSF2R P85A â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 12538575 17474147
1433G P85A â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 17353931 15324660
LTK P85A â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 8084603 9223670
P85A CAF1A â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 17474147 26496610
SHIP1 SH3K1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 22815893 15090612
CBL ERBB2 â—¼   PHYSICAL_INTERACTION 861.0 0.86 STRING 36370105
ABL1 CTNB1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 23950177 17318191
EGFR SH3K1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 16849543 11894095 12771190 12218189 12734385 15456872 21635887 12177062 33643898
GHR GRB2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 17474147 9632636
SOCS1 GRB2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 10022833 29991678
CRKL PTN11 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 9660791 9344843 23397142
MET CRK â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 24828152 24728074
CRK CBLB â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 33961781 19380743 25814554
CRK SOCS1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 10022833 25814554
GAB1 LCK â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 34079125 24728074
VAV JAK2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 9162069 7530656
SRC KIT â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 24728074 12878163 12444928
BCR RAC1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 9535855 31871319
SRC RASH â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 30194290 12695509 30639242
FGFR1 P85A â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 25241761 18412956 8321198 15117958
GRB10 IRS1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 8621530 12783867
P85A IGF1R â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 8603569 25241761 7642582 8697095 7589433
SOCS1 MET â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 25728680 24728074
ERBB3 PK3CA â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 11546794 19411071 24189400
GHR P85A â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 17474147 9632636
FAK1 P55G â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 22402981 32296183 25814554
PK3CD P55G â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 32296183 33961781
CD28 GRB2 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
CRK SRC â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
GRB10 ABL1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 9006901 9747873
ARAF P85A â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 11812000 10967104
LCP2 CBL â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10477741 10204582 9716598 19635790
JAK2 EGFR â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 24240702 9363897 10635327 16273093 23838182 10358079
ESR1 EGFR â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16713569 28065597 20935677 11887937 17284441
NISCH IRS4 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 25036637 11912194
CBLB CRKL â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10022120 25814554
CRKL KIT â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 11071635 9092574
LCP2 P85A â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 21282515 15388330 15929943
SHC1 SRC â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
CRK P85A â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 25241761 11418612 10962563 12878163 25814554 19380743
KIT LCK â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 9788619 24728074
P85B FYN â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16713569 1334406
SOCS1 FYN â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10022833 16713569 29991678
CSF1R FYN â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 7681396 16713569
JAK2 FYN â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16713569 10551884
FYN CTNB1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 12640114 25241761
IRS1 JAK2 â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
GHR JAK2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 24280222 10502458 21347402 7540178 8063815
CDC42 RAC1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 31871319 9427749
SRC RET â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16189514 33961781 32062451 10070972
IGF1R IRS1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 7559507 8776723 10082579 7541045 8530377 33991522 8895367 12220227 15629149 8662806
P55G IRS1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 9415396 10417350 25814554 7542745
IRS1 KHDR1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 22005517 11604231 8175658
SOCS1 VAV â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10022833 10747851 29991678
IRS2 P55G â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 33961781 10417350
NTRK1 P85A â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 25921289 8226808 8384556
GAB1 MET â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
PTN11 SOS1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16371368 9632781 9344843 20473329
P55G ERBB3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 22973453 16273093 24189400
GHR PTN11 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10976913 9442080 9632636
EPOR SHIP1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 15644415 10660611
TGFR2 P85B â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 33961781 9435577 26186194
P85B PK3CD â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 9113989 19380743
KSYK PTN6 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16189514 34362877 10871605 10747947 10072516 11356834
UFO P85A â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 9178760 18346204
FAK1 P85A â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16713569 19889638 10806474 7537275 11104793 10973983 8649427 11119718
HAVR2 P85A â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 33961781 26492563
VGFR1 P85A â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 23397142 20805333 7657594
P85A TGFR2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 33961781 9435577 26186194
P85A FCG2A â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 9268059 8631888
FAK1 PTN11 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16189514 10082579 21726809 20473329 7589239 10655584 8986614
PTN11 MET â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 8662733 18579758 24728074
CRK EGFR â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
CRKL EGFR â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
BCR GRB2 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
CRKL GAB1 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
ABL1 DOK1 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
CSF1R GRB2 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
GRB10 INSR â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
ABL1 GRB2 â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
IGF1R SHC1 â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
CBL LCK â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
EGFR MET â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
GRB10 IGF1R â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
CBL SHC1 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
GRB2 KIT â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
NTRK1 ABL1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10708759 10679771
VAV ABL1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 19234221 11790798
ABL1 1433G â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 15696159 25852190 33961781 16888623 30021884
P55G EGFR â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 25241761 31980649 22973453 24658140 16273093 25402006
UFO EGFR â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 35022314 25873175 27775700
CBLB EGFR â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24797263 11375397 20308550 19531499 33848699 10635327 30515972 18271526 28572092 10086340 16729043 31959764 16702950 15657067
EGFR MK08 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24658140 25402006 31980649
EGFR RET â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24658140 25402006 31980649 28460442
EGFR LAT â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24658140 25402006 31980649
EGFR AKT1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24658140 25402006 31980649
EGFR DOK1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24658140 25402006 31980649
EGFR LCP2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24658140 25402006 31980649
EGFR CRKL â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 31980649 24658140 25402006 18271526 25754235 16729043 23397142
GRB2 LCP2 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
CD28 GRB2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 9694876 27927989 7737275 7584133 8576157 24475931
NTRK1 GRB2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11733534 25921289 10748052
UFO GRB2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 9178760 16189514 18346204
EPOR GRB2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16713569 7534299 9129019 8647802
RET GRB2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16189514 32062451 9393871 8183561 7665556 10995764 15677445
ERBB3 GRB2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 9756944 24189400 24658140 16729043 11173924
P85B GRB2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 19380743 21706016 8662998 20936779
GAB2 CRKL â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 9660791 11334882 10871282
CRKL BCR â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 15143164 8978305 10194128 9747873
LCP2 PTN6 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 9765283 15588985 16189514 8760799
GAB2 SHC1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 12135708 14982882 10704825 11782427
IGF1R SHC1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 7559507 24051437 8776723 7541045 14764897 15629149 16113100
SHC1 MET â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 7731718 24728074 9660480
PGFRB CRK â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16713569 16189514 10733900
GAB1 CRK â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 12138161 16713569 24728074 19380743
RET CRK â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 25241761 32062451 10208419 9393871
P85B CRK â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 31980649 19380743 25814554
PK3CA LCK â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 14583609 8020561 8246987
KHDR1 LCK â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16888650 16274251 7852312 11278465 9045636 16107303
LCK P85A â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 8294442 9461588 7504174 34079125 8246987
SRC FYN â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 31980649 19711372 9169421 33961781 16966330
P85A FYN â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 25416956 16713569 8294442 7520528 8394019
KSYK FYN â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16713569 16189514 9535867
P85A JAK2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17474147 8702385 16135792 10026141
PTN6 JAK2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 8943354 10772872
P85B KIT â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10022833 7537096 24728074
RAC1 P85A â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 8034624 12086876 25284480 32814053 7629060 31871319 26475863
PGFRB SRC â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 2173144 16189514 17785434 17158602 7678051 7685273 18315570
SRC P85A â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 12210743 25241761 16713569 23065768 12393736 24498420 7499252 10487518 32814053 16230374 23397142 19861161 19903481
CBLB VAV â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11857085 16189514 9399639
IRS1 PK3CA â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16150444 12933652 23643389 16354680 27684187 23604317 14511371
1433G IGF1R â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17353931 15324660 27684187
INSR IRS2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 8662806 8626379 9195949
GRB10 RET â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 7665556 28794017
P85A ESR1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 23065768 16713569 17043237 11689445 11029009
CD3E KSYK â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 9698567 7761456
P85B PK3CB â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 22402981 33961781 26186194 19380743 32707033
P85B PK3CA â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 22402981 26496610 25253337 14681455 19380743 27684187 23604317
PTN6 P85A â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11337495 9452499 11160222 10488096
ADA12 P85A â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 25825872 11313349
VAV P85A â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 9162069 16713569 9891995 17050525
WASP P85A â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10358777 8805332 16713569 17242350
PTN11 P85A â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 9361008 9660791 9886492 8647120 11593409 9918857 9565634 26839216 9632795 16371368 10962556
INSR SHC1 â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
EGFR GAB1 â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
CBL EGFR â—¼   UBIQUITINATION ✅ - 0.89 0.89 Signor 20332299
EGFR CBL â—¼   RELOCALIZATION ✅ + 0.89 0.89 Signor 16829981
ERBB2 SRC â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
SRC ABL1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11494128 17474147 12522270 11781820 17318191
CRKL ABL1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16443220 22286129 7493940 14604282 8978305 9820532 18835194 9710592 33961781 8524328 19823681 7926767 16955467 24412932
ABL1 GRB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 23950177 16713569 17474147 14725908 9407116 9516488 8194526 19380743 19823681 7926767 16955467
ABL1 BCR â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12543778 1712671 8112292 21653319 11780146
ABL1 EGFR â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31980649 24658140 16273093 25402006 7678409
ABL1 P85A â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 1383690 16135792 8781408 17474147 8294442 16219545 19380743
ABL1 CBL â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15556646 11494134 16713569 9174058 20675402 9195915 14604282 10829062 14725908 8626543 12475393 19380743 19823681 16955467
GRB10 ABL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9006901 23331499 9747873
1433G ARAF â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 31980649 28628118 29777862 17353931 28205554 25852190 32707033 15324660
EGFR CBL â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 27059931 7657591 8665853 27903975 15107835 24797263 28791635 9756944 23799367 23175185 28198003 12734385 14505571 20940296 19155296 10635327 15117950 22833562 29629558 12061819 8662998 10086340 33762435 11994282 20877636 32714745 25005938 31182136 19578043 7782294 24714105 10799548 23158001 26055326 33617900 23153581 15210722 25872741 15657067 19947936 10428778 18508924 16969069 17971399 15962011 19531499 25521828 23774213 22976291 31959764 22591401 18255265 15735736 16713569 20562913 17880946 16914641 9890970 22394513 16729043 32114396 17995934 17182860 18319245 18271526 17545148 15383614 25140053 32377695 15465819 33627783 8798643 25754235 15282549 26177020 22266821 16923119 17242169 30544639 12604776 11239464 9130710 19225046 11370743 21772844 16105874 18273061 7592693 23897813 17486068 16246327 23457600 32904620 12803489 31120930 15668240 22203672 23418353 20124286 28541302 33323455 10092522 14627991 15677445 15159412 20308550 16849543 12593795 19836242 9121472 19713535 18316398 11408594
SRC CBL â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 29899407 17094785 16713569 18273061 7782294 12941616 10829062 31120930 15135048 17141222 18996392 8635998 11994282 22203672 19861161 16636290
CBL P85A â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11030146 10918571 17237826 16982329 14530346 9174058 9918857 11418612 11087752 9890970 25814554 9178909 15581361 9890943 19861161 15107835 9259313 8612729 9414268 7544353 21203488 18374639 8695807 10620516 7791764 10025673 9160881 8941725 8896416 8662998 9461587 16219545 11042121 19380743 19190244 16289966 7642581 11994282 8702998 11157475 11944898 9092538 16135792 15556646 16713569 8621719 9541596 24113870 33512474 9988765 9234717 8995243 11133830 10358153
CBL RET â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 32062451 12727845 15677445 28794017
CBL VAV â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16356860 16713569 9200440 18835194 19635790 11331248 16289966 11133830 12881521
CBL MET â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11894096 25241761 18273061 19433454 21222362 19450681 21163258 16397241 17533376 15123609
IRS1 CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10854852 19546233
CBL IGF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18632619 17635922 10514377
SRC EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.9 0.9 mint 17284441 6169640
GRB10 EGFR â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31980649 24658140 9506989 25402006 9006901
VAV EGFR â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31980649 10938113 22973453 24658140 16273093 25402006
ERBB3 EGFR â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21278786 24189400 27756321 18803307 17148612 25315821 22439932 10527633 23436906 23866081 10572067
PTN6 EGFR â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9733788 22973453 25187647 7673163 28065597
P85A EGFR â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21701776 25241761 16713569 7499252 19531499 22973453 25187647 8662998 16273093 25754235 7797556 31959764 16230374 7531698
PTN11 EGFR â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9756944 22973453 20473329 7673163 28065597 14560030 24935154 11223155 16273093 8959326 12270932 16729043 7588774
FAK1 EGFR â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31980649 16713569 24658140 20473329 10806474 25402006 15657067
EGFR MET â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 20624308 24189400 21918175 24362532 10722725 23866081 26551075
EGFR CRK â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16729043 9642287 31980649 10595738 22973453 24658140 11956190 16273093 9617486 25402006 12198159 8875975 9480911
EGFR P85B â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31980649 23956138 11172806 19531499 24658140 22973453 16273093 25402006 1334406 31959764
EGFR CTNB1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9535896 24189400 9233779 11950845
EGFR ERBB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11500850 25241761 30898150 17486068 11526509 9461599 23866081 17426253 10572067 11500516 24557338 8665853 15657067 19060928 16516204 19650109 20211985 25315821 23436906 21278786 25898135 32669362 1346931 24189400 21044682 18803307 16843263 28369073 7531698 16713569 17148612 21203579 17307140 1706616 16207817 7797556 12354693 11408594
EGFR GAB1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 23066441 31980649 10913131 9890893 24658140 10648629 21278788 25402006 10734310 18271526 19401591 11432805
CDC42 GRB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
MET GRB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11063574 15546961 9660480 19433454 21222362 7511210 8662889 11439336
PGFRB GRB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 7935391 7486683 16189514 16713569 9362449 10026169
KIT GRB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16713569 24728074 7523859 17452978 17904548 10377264 8950973 10022833 7523381 12444928 8647802
LAT GRB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 7544353 16906159 12186560 16189514 9489702 16713569 8063801 16938345 10811803 12359715 23460737 11368773
JAK2 GRB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 7500025 17474147 8536716 8950973
IRS2 GRB2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 19109239 7890616 9535722
IRS4 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9553137 15316024
EPOR GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8647802 16713569 7534299
FYN GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7499280 9344857
DOK1 CRKL â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11071635 11553620 9822717 25814554
CRKL P85A â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16135792 16982329 11418612 9461587 32203420 23397142
SOS1 LCP2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11390650 10021361 10224278
LCP2 VAV â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 10347175 9341187 21725281 8703037 19635790 11331248 9047237 8673706
NTRK1 SHC1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 25921289 7541035 28213521 9856458 10092678 10629055 29715200 8226808 8183561 10708759 8155326 12446789
SHC1 P85A â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16135792 16713569 7537361 8621719 9541596 19889638 8662998 16219545 19380743 23397142
SHC1 ERBB3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 9019162 9756944 24189400 22973453 24658140 16273093 16729043 11546794 8665853 9694850
SHC1 ERBB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9710588 9019162 16713569 9756944 22973453 24658140 10085134 28065597 30898150 16843263 16273093 16729043 8665853
SHC1 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 20935677 11773443 16713569
SHC1 RET â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 32062451 8183561 28213521 15677445 9047384
MK08 CRK â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16982329 11432831 25241761 16713569
IRS4 CRK â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9614078 11316748 16713569
CRK KIT â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9092574 24728074 9233773 12878163
CRK FAK1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 10085298 7561682 7529876 7509446 11314030 12615911 25814554 12370821
PTN6 LCK â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11294838 16189514 19167335 10488096 8692915 7512963 10574931 8114715 12468540 10617656
KSYK LCK â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 8798676 8621719 15536084 7539035 8798764
LCK LAT â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16938345 12186560 12359715 14523017
LCK GAB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11572860
LAT P85A â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 7544353 10811803 11368773 16713569
LAT VAV â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 17306257 12186560 11368773 16713569
FYN LAT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16938345
JAK2 GAB1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15644415 12506011 10455108
KIT SOS1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 8950973 16129412 10377264
P85A KIT â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 7509796 25241761 1382595 16713569 24728074 17452978 12878163 11071635 7537096 10022833 9233773
PTN6 KIT â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12614164 9528781 7684496
PTN11 KIT â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9528781 7523381 24728074 12444928
SRC ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 24498420 14766010 15604093 11013076 27420286 29720121 12736255 18451880 15140878 23065768 17043237 17627277 7539106 11032808 17363140 20935677 14963108 11564893 12630920 22328528 15020686 15784253 17921256 24051437 10454579 17400812 17284441 16957778
SRC ERBB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 22973453 11940572 17875712 19372587 21075308 29720121 7542762 7797556 19704002
SRC MET â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 24034250 20624308 9837958 24728074
ESR1 SRC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20160136 20460377 22865929
P85A CDC42 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 8034624 7629060 25284480 31871319 9381982
CDC42 WASP â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 10713100 9660763 12769846 10068673 10360578 10360579 28539360 9422512 10684602 15361624 10802735 8625410 25502805 10724160 20936779 22252508 15075243 12235133 8643625 9742969
CD28 P85A â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9417079 24475931 8164687 8146197 7957566 8183372 7807015 8621607 10820259 27927989 11526404 7568038 18641334 19190244 9820515 7509360 7737275 7584133 17242350
CBLB SH3K1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19268472 32296183 16189514 12829691 12874286 12218189 16228008 18680311 23663663 12177062 19531213 17020880
MK08 IRS1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 10722755 11606564 12351658 12417588
LTK IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 9223670
SOCS1 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12228220 17276034 11208867
P55G IGF1R â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 17360667 9415396 25241761 9524259
PTN11 IGF1R â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 10082579 7642582 8895367 28065597
GAB1 IRS2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15644415 12506011 10455108
1433G IRS2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 17353931 33961781 15324660
IRS2 P85A â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9334184 12107746 15514089 12506011 26496610 11438664 8910607 23439647 19561084 9852124 21241768
PTN11 INSR â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 8895367 7493946 8135823 9593725
P85B ERBB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16729043 22973453 16273093 1334406
ERBB2 CTNB1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 7702605 11245482 11950845
ERBB2 PTN11 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9756944 22973453 28065597 16273093 8959326 16729043
ESR1 RET â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21737465 21947652 22878616
EPOR GAB1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15644415 12506011 10455108
ERBB3 P85B â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16729043 22973453 16273093 24189400
KSYK VAV â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 8900182 11331248 8986718 11262396
KSYK FCG2A â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9268059 8756631 11141335 7487883 9295288 9280292
PGFRB P85A â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 10752619 7536927 9153411 8382612 10697503 1314164 15377662 8388538 19864249 11710529 1330535 7680644 7678051 7531698 1372092 7486683 16135792 16713569 8564419 7692233 11896612 8670861
RASH P85A â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16713569 25241761 9150145 10212255
CD7 P85A â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12594831 33961781 8918688
SH3K1 P85A â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15476827 17474147 11071869 10921882 20457601
ABL1 CRKL â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
EGFR SOS1 â—¼   PHYSICAL_INTERACTION 905.0 0.9 STRING 36370105
GRB2 SOS1 â—¼   RELOCALIZATION ✅ + 0.9 0.9 Signor 23452850
ABL1 CBL â—¼   PHYSICAL_INTERACTION 909.0 0.91 STRING 36370105
BRD7 P85A â—¼   PROTEIN_INTERACTION 0.91 0.91 HIPPIE 30940648 24657164
CBL MET â—¼   PHYSICAL_INTERACTION 909.0 0.91 STRING 36370105
JAK2 SOCS1 â—¼   PHYSICAL_INTERACTION 909.0 0.91 STRING 36370105
SRC ADA12 â—¼   PROTEIN_INTERACTION 0.91 0.91 HIPPIE 25825872 11127814
1433G IRS1 â—¼   PROTEIN_INTERACTION 0.91 0.91 HIPPIE 28514442 30240640 15324660 33961781
PK3CD RASH â—¼   PROTEIN_INTERACTION 0.91 0.91 HIPPIE 22020336 10922060 9113989 11739523 9235916
SHC1 SOS1 â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
DOK1 RET â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
GRB2 IRS1 â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
GRB2 CBL â—¼   RELOCALIZATION ✅ + 0.91 0.91 Signor 11823423
ERBB3 SHC1 â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
ERBB2 ERBB3 â—¼   PHYSICAL_INTERACTION 916.0 0.91 STRING 36370105
INSR IRS1 â—¼   PHOSPHORYLATION ✅ + 0.91 0.91 Signor 7651388
FYN CTLA4 â—¼   PROTEIN_INTERACTION 0.92 0.92 HIPPIE 9712716 25241761 9973379 16713569
ERBB3 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 31862538
LCP2 GRB2 â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 17235283 5219525
GRB2 ERBB2 â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 16273093 5218056
GRB2 BCR â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 5214841 11726515
FAK1 SHC1 â—¼   PROTEIN_INTERACTION 0.92 0.92 HIPPIE 11980671 16189514 16713569
GHR SHC1 â—¼   PROTEIN_INTERACTION 0.92 0.92 HIPPIE 9632636 7535773
SHC1 JAK2 â—¼   PROTEIN_INTERACTION 0.92 0.92 HIPPIE 7535773 9126968
RAC1 WASP â—¼   PROTEIN_INTERACTION 0.92 0.92 HIPPIE 16189514 8643625
ERBB3 PTN11 â—¼   PROTEIN_INTERACTION 0.92 0.92 HIPPIE 28065597 22973453 9756944
PTN6 VAV â—¼   PROTEIN_INTERACTION 0.92 0.92 HIPPIE 16189514 8632004
EGFR GRB2 â—¼   PHOSPHORYLATION 0.92 0.92 Signor 11726515
ESR1 SRC â—¼   PHYSICAL_INTERACTION 921.0 0.92 STRING 36370105
ERBB2 SHC1 â—¼   PHYSICAL_INTERACTION 922.0 0.92 STRING 36370105
INSR IRS1 â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
CBL FYN â—¼   PHYSICAL_INTERACTION 925.0 0.92 STRING 36370105
CBL VGFR1 â—¼   PROTEIN_INTERACTION 0.93 0.93 HIPPIE 25387128 18273061
PTN6 PGFRB â—¼   PROTEIN_INTERACTION 0.93 0.93 HIPPIE 19167335 9452499
EGFR SRC â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
CBL SRC â—¼   PHYSICAL_INTERACTION 936.0 0.93 STRING 36370105
SHIP1 SHC1 â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 12149229 10822173 8643691 8723348 15470047 10194451 10900203 11453982 10704825 12024011 8874179
P85A KSYK â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 15536084 16921024
P85A CTNB1 â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 10477752 25241761 11716761
ERBB3 GRB2 â—¼   PHYSICAL_INTERACTION 948.0 0.94 STRING 36370105
CBL LCK â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 7721825 8621719 8900205 8626543 9178909 16107303 11741956 11904433
ERBB2 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 5218411 16516204
SHIP1 GRB2 â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 12149229 9108392 8723348 22267732 10900203 11453982
VAV FYN â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 9822663 16189514 11262396 16713569
SOS1 FYN â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 17474147 16713569 9856337
JAK2 IRS1 â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 11208867 12960006 9492017 15316008
SRC CTNB1 â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 23246962 11279024 22056988
VAV CDC42 â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 11287617 16189514 18511940 32203420
P85A ERBB2 â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 12896906 9756944 22973453 16843263 16273093 21075308 1351056 7531698
DOK1 RET â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 12087092 16153436
MET GAB1 â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 10871282 10913131 10995442 10734310 9242692
RASH PK3CA â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 8665852 14724584 10783161 9150145 24412244
CBLB EGFR â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
ERBB2 GRB2 â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
GRB2 CBL â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 5220480 7642581
EGFR CBL â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 16729043 5218694
P85B CBL â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 7629144 19380743 19190244 25814554 11133830 15107835
SHC1 CBL â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 10570290 10025673 16713569 8621719 9541596 8662998 9461587 9434624 9234717 8950973 19380743 15677445
CBL CSF1R â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 11850825 10025673 10648820 7782294 11847211
CBL EGFR â—¼   COLOCALIZATION ✅ 0.96 0.96 mint 16914641 7033849 028274
SOS1 EGFR â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 24797263 16713569 26005835 9447973 23956138 19531499 7510700 20473329 19289468 25754235 18271526 31959764 10675333 8621459
CBLB GRB2 â—¼   PHYSICAL_INTERACTION 959.0 0.96 STRING 36370105
CSF1R GRB2 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 10025673 8262059 7597091 9380408 9178909
WASP GRB2 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 16189514 8892607 16713569 9307968 10224664 8805332
PTN6 GRB2 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 10660620 16189514 8632004 11964172 25535246 10747947
GRB2 SH3K1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 11152963 16189514 31980649 16713569 10921882
GAB1 CRKL â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 25241761 10871282 24728074 30480076 10753869 23397142
CRKL EPOR â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 11443118 9344843 9129019
GAB1 SHC1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 9804835 24728074 12808090 14982882
SHC1 SOS1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 8631299 10570290 10025673 8235613 8626525 9544989 10675333 10783152 8950973 7559490 19380743 16371368 9344843 7520523 8621459
PTN11 JAK2 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 7559603 8995399 9442080 8639815 8912646
SOCS1 JAK2 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 11314018 14517242 14522994 10421843 19287004 29674694 10064597 18508766 9202126 9344848 11971965 11713228 29991678 28258213 10455112
JAK2 EPOR â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 14982882 12441334 11779507 8343951
VAV RAC1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 16397238 11287617 32203420 18511940
WASP SRC â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 8824280 8805332 16189514 16713569
PTN11 GAB2 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 14982882 9660791 10871282 11782427 16253990 11287610 12135708 15170389 26839216 16371368 11812650 19909739 11334882 10068651 19172738 10391903 15356145
GAB2 P85A â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 9660791 16135792 10871282 11782427 16253990 14530346 26839216 12506011 16219545 11334882 10068651
SOCS1 CSF1R â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 10022833 11297560 29991678
INSR P85A â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 11796522 8276809 8385099 1334490 10500481 8567177 14729945 9593725 7589433 15629149 7659087
DOK1 SHIP1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 11071635 15151996 10822173
P85A EPOR â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 9162069 16713569 24113870 12506011 7559499 15644415
PTN6 EPOR â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 7528537 7228577 7889566 7528577
P55G PK3CB â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 22402981 33961781 25814554
P55G PK3CA â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 22402981 9415396 26496610 14681455 33961781 25814554
FYN SRC â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
DOK1 ABL1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 9008161 22974441 10688886 11071635 9822717 10567556 19823681
ABL1 CRK â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 31980649 9747873 11380621 15696159 8875975 9480911 21602891 18835194 18619508 12384576 8194526 11956190 19380743 24412932 9642287 17474147 8978305 12097319 17515907 33961781 12198159 7926767
FYN CBL â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 17094785 8900205 15190072 9890970 25814554 8995358 12244174 10829062 12941616 9311917 12231245 16503409 9677430 8662998 119942 9535867 10092522 15208330 7642581 15556646 16713569 8621719 10629042 7782294 8626543 10799548 11239464
KSYK CBL â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 7721825 12435267 15556646 18273061 27614019 8621719 15536084 31120930 15577829 11331248 10617633 11742985 16289966 11042121 9857068 11133830 10570266 10540342
SH3K1 CBL â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 19268472 28514442 31980649 20130058 29589748 12177062 15107835 25036637 10679202 15090612 12618476 19417776 22262777 11152963 25472714 11894096 12135478 17072306 11894095 15962011 20711168 24167568 22833562 21830225 33627783 14596919 17306257 25005938 12874286 16713569 17675467 16407834 16228008 11071869 33961781 15456872 19531213
CRKL CBL â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 9162067 9129019 16982329 9590251 8621483 25814554 10907644 10608804 15107835 7545163 9092574 9195915 12244174 18835194 9311917 8524328 16503409 24886428 10657627 14604282 9820532 8662998 9461587 9851874 11399323 9344843 11157475 10204582 9660791 15556646 8978305 11553620 8626543 9988765 33961781 11263968 15358160 11133830
CBL CRK â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 31980649 9129019 9416834 22974441 8621483 25814554 9178909 15581361 18835194 8943292 12393469 8524328 8683103 8662998 10962563 9461587 19380743 16289966 11792427 8626543 9988765 33961781 9617486 8626404
SHC1 EGFR â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 7518560 8034616 31980649 23956138 9544989 8610109 7542744 25402006 16729043 8665853 15657067 9742218 24797263 10049786 12577067 9756944 23799367 25187647 20935677 10766863 18271526 11408594 7506413 10635327 10595738 24189400 19531499 7542991 20473329 24430869 8662998 9020193 8887653 16273093 25754235 9388490 31959764 26551075 16713569 22973453 24658140 11196191 28065597 20067773 8810340 21278788 30544639 9130710 11370743
SRC EGFR â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 31980649 8845374 21573184 25402006 7506422 10075741 19704002 10971656 23175185 10777553 22227249 20935677 20624308 21268077 17158602 24189400 9020193 16713569 22973453 11983694 24658140 28065597 21278788 17284441 7797556 20333651 7527393 10358079
EGFR GRB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 19254954 7518560 31980649 9416834 7592693 23956138 14679214 10085134 7510700 27059931 21706016 25402006 16799092 16729043 8665853 15657067 24797263 12577067 8810325 7650032 11960376 23799367 25187647 8626525 10026169 19289468 18271526 21278786 7506413 17971399 8940013 20124286 11726515 9886492 10595738 24189400 9020117 19531499 20473329 9020193 8662998 8647858 1322798 8887653 10229072 16273093 25754235 31959764 11370743 16713569 21596750 9685397 24658140 31985874 22973453 11896612 20067773 17242169 19836242 8810340 21278788 30544639 7527043 9050991 11408594 8621459
SHC1 GRB2 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 8940013 6169950
SOS1 GRB2 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 5220480 7642581
PTN11 GRB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 8995399 16189514 31980649 21706016 16371368 8702859 34407391 9361008 12577067 9362449 7523381 9824671 10212213 12531430 20473329 10080542 8959326 19380743 9254654 8041791 9660791 9632781 8647120 33961781 10747947 7534299
FAK1 GRB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 10085298 21900206 16189514 16713569 7597091 20473329 10806474 8816475 8649427 12558988 12005431 7997267
ERBB2 GRB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 9710588 11173924 21278786 16713569 9756944 24189400 31980649 22973453 24658140 30898150 16273093 17875712 16729043 11606575 8665853
KHDR1 GRB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 16713569 10467411 7537265 11960376 21988832 11278465 21706016 22745667 8576157 9045636 20936779 9872323 12112020 7799925
IRS1 GRB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 7488107 8388384 7486683 8810325 22974441 21706016 8491186 7629070 12173038 8536716
BCR GRB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 8112292 11726515 15143164 9747873 10887132 8995379 8955135 9174058 14725908 21706016 33961781 19380743 32203420 9178913 7529874
LCP2 GRB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 8695800 11314042 10204582 8995445 15929943 12176364 25416956 32296183 9565634 10224278 7706237 20936779 19380743 17235283 9716598
VAV GRB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 16189514 16713569 8900182 8647120 9013873 7809090 18692475 29997244 16339550 15558030 32203420 10207103
P85A GRB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 25416956 9174058 11418612 21706016 7544353 18346204 7737969 9886492 16219545 19380743 7642581 7759531 16713569 8621719 7642542 9541596 8647120 32814053 20936779
GAB1 GRB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 11314042 22536782 10871282 31980649 10913131 11960376 9804835 9890893 20473329 21706016 33961781 20936779 19380743 9242692 8596638
GAB2 GRB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 25416956 31980649 21706016 10068651 16371368 10391903 32296183 15143164 10913131 19523899 19172738 11782427 19380743 11882361 9660791 16253990 33961781 20936779
CRK GRB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 8810325 10962563 8662907 19380743 10970810
SRC SHC1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 10482988 16189514 7499252 9096689 9710204 18840094 8939605 9388490 26551075
SOS1 CRK â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 25241761 31980649 8810325 17474147 8943292 33961781 19380743 32203420
WASP FYN â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 16189514 16713569 10532312 7565724 14707117 12431372 10224664 8805332
KHDR1 FYN â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 16888650 31980649 16713569 11960376 7516469 15190072 22745667 9045636 14647465 31413325
FAK1 FYN â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 16713569 31413325 32707033 12558988 11278857
SRC FAK1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 11980671 16189514 25241761 23242524 17525734 25814554 12615911 16291744 21034468 10931187 21855630 23065768 9507031 12387730 8816475 11119718 8941336 8054685 15987550 26264872 7529876 11104793 16966330 9822703 7997267 10085298 16713569 22402981 32814053 12558988 11927607
GRB10 IGF1R â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 18286479 8764099 9369444 12697834 8621530 8776723 9506989 19165858
GRB10 INSR â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 10871840 9369444 12551896 8621530 7479769 9506989 12493740 19648926 9006901 15664450
ERBB3 ERBB2 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 31862538
ERBB3 ERBB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 10799311 12896906 25241761 30523157 23680147 30898150 19411071 17426253 10572067 11173924 24557338 23866081 8665853 19060928 25326665 7592681 25315821 22733765 21075308 23436906 8816440 21278786 25898135 15812817 7538656 16843263 20227043 23688700 15504738 22806884 17148612 21203579 9130710
PTN11 GAB1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 10871282 24728074 11134009 10068651 11323411 14982882 11940581 20308328 9632795 11453982 23612964 14665621 9658397 20473329 12855672 15574420 9804835 14701753 24935154
GAB1 P85A â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 9658397 11940581 24728074 10978177 9804835 12506011 9632795 16638574 23612964 8596638 11606067 9891995
RASH SOS1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 17084389 16713569 12628188 19141281 11560935 26721396 18454158 9447984 20133692 15507210 9690470 34407391
ERBB3 P85A â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 12896906 21278786 9756944 24189400 22973453 18803287 11389077 10383151 22439932 11694521 16273093 21075308 20007781 9130710 10572067 11546794 20227043 15812817
TGFR2 TGFR1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 19556242 21423151 7878020 10026191 8576253 19758997 21791611 11483955 33961781 11102446 25825445 23868260 7890683
PK3CB P85A â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 10358930 25241761 20713702 24657164 26839216 26496610 32814053 21825134 33961781 27107012 32707033 22939629 8139559 26344197
KHDR1 P85A â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 11604231 16713569 10467411 7537265 22745667 10437794 8175658
PK3CD P85A â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 22020336 31031754 32296183 24165795 9113989 21827948 26496610 18641334
P85A PK3CA â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 19805105 26839216 9565634 19117013 27684187 9235916 18079394 23643389 26496610 7957566 28205554 26475863 15377662 11526404 20018188 24657164 25253337 15932879 19574958 16135792 28628118 22402981 20713702 33420362 32814053 7929193 16043515
EGFR ERBB3 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
NTRK1 SHC1 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
EPOR JAK2 â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
ABL1 CRK â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
GAB2 GRB2 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
SHC1 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 16729043 5218694
GRB2 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 16729043 5218694
EGFR ERBB2 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
IGF1R IRS1 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
ARAF RASH â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 28628118 10545207 28205554 24441586 12620389
SHC1 GRB2 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 12485888 21725358 31980649 9126968 7514169 7744881 8235613 11453982 8662733 8491186 7629070 8940013 10570290 8112292 12213123 11302736 8662998 8195171 7597091 8810340 32062451 9129019 16371368 12149229 10049786 8626525 7650032 8950973 9488479 24189400 15812354 12441060 19380743 26551075 22057045 10477741 28690151 16713569 7516467 9733714 11827484 11964172 7537740 16520382 9019162 8663178 9797459 9032244 12577067 9927207 7524086 8995379 9886492 8294403 7559490 9434624 11792427 7798267 8621719 9541596 15688026 12898421 33961781 11370743 25416956 9544989 22974441 8939605 21706016 9083103 7535773 11505033 9175774 24430869 10080542 9020193 9045692 10356320 15888547 9254595 8561895 11707405 8647288
CBLB GRB2 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 21900206 28514442 16189514 25416956 31980649 12577067 31467278 26264872 10022120 9614102 29997244 21706016 32814053 33961781 20936779 10086340 27107012
KHDR1 SRC â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 10635328 16713569 7537265 10467411 11960376 1374686 15190072 22745667 16169070 8766817 18606683 1545818 9038356
INSR IRS1 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 11781100 25667086 16582879 17167487 7935368 10455177 11606564 7499194 15629149 8662806 8626379
P85A IRS1 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 29526746 16150444 14632132 22974441 8628286 26839216 8382612 7680095 33991522 25814554 16880210 19561084 16230374 8175658 7659087 8388384 1381348 23643389 23439647 7935461 12107746 11403293 15514089 7680644 12173038 25273559 14511371 12730242 11416002 7486683 17640984 1334490 30240640 16354680 12220227 9564850 16043515
PTN11 IRS1 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 11781100 22974441 7513703 9756938 9535915 8505282 7935386
PTN11 PGFRB â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 16189514 8538796 12614164 7530043 8119896 23922991 7688466 7691811 8183548 12681492 23397142 8041791 11266449
GAB1 GRB2 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CBL CRKL â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
CBL CRK â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
EGFR SHC1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
CBL GRB2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CBL EGFR â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EGFR GRB2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
GRB2 SOS1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ABL1 CRK â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 10837221 15459660 18835194 21051857 21199784 21435002
ABL1 CBL â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 10837221 15459660 18835194 21051857 21199784 21435002
ABL1 CRKL â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 10837221 15459660 18835194 21051857 21199784 21435002
FYN ABL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12522270 16787943 17570479 16912036 16076903 17474147 11847100
SRC ABL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 44.0 1.0 Omnipath 19901323 10964922 16497976 20841568 16787943 17570479 17318191 11847100 10500097 12522270 18691976 11494128 11781820 16076903 20168609 12748290 16464493 12445832 19369195 17474147
LCK ABL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16076903 16787943 17570479 11847100
NTRK1 ABL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 10708759 10679771
ABL1 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12560071 20841568
ABL1 CRK â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 100.0 1.0 Omnipath 8978305 9747873 9480991 19426560 17081983 23124138 16522685 16713569 20841568 18768933 8875975 25860930 21779437 19534553 16187300 17515907 21602891 16267043 20068231 10592173 17570479 8194526 7926767 11080615 25381819 12198159 9642287 15696159 18619508 18835194 11956190 22848689 11314030 9480911 19001122 19402756 20697350 12384576 24412932 7542925 11380621 12799422 19380743 12955086 17474147 17016520
ABL1 BCR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 9407116 10405761 12522270 11780146 8622703 9178913 1712671 12124177 7529874 9467953 8955135 20841568 8112292 16912036 12543778 11376433
ABL1 JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 16705159 15923602 15793561 25821558 9111318 15143187 16705160 11593427 20841568
ABL1 CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 45.0 1.0 Omnipath 9525940 11494134 16713569 20841568 10829062 17389395 16955467 12604776 9890970 10391678 9195915 14725908 7925293 11997497 12522270 15556646 9102067 11239464 11994282 9174058 12475393 20675402 19380743 14604282 8626543 15212693 19823681
ABL1 CRKL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 55.0 1.0 Omnipath 8978305 22581121 20841568 10837221 18768933 7493940 9710592 16955467 8524328 23331499 21199784 18794134 10592173 21051857 7926767 16443220 18835194 24165979 26500649 18809728 15459660 26192618 24412932 9053848 22286129 8083188 14604282 21435002 9820532 19823681
ABL1 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15039778 20841568 8112292
ABL1 MET â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 9826708 12766170 9391119 9242692 10506185 8547236 10069803 7687741 10490849 11741535 21777671 8906793 12475979 9444958 7513258 7961992 15475459 9252406 7838524 7731718 8662889 7708691
ABL1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 34.0 1.0 Omnipath 11726515 16713569 20841568 8596638 16955467 10592173 8647802 8194526 7926767 14725908 23950177 8112292 9407116 23181695 19380743 17474147 9516488 19823681
ABL1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 55.0 1.0 Omnipath 24430869 15192046 33889303 16273093 16943190 14760089 29880877 15618223 33574089 8910327 12631709 25173817 25402006 20841568 33947961 34107301 34469737 19915609 32019812 2022651 34290403 33707748 15329413 7678409 9733788 8490966 28338646 3263271 15901825 2022652 10069801 7506413 24658140 8408058 34385595 31980649 1314835 7741752 18668345 28724430 12648464 25073158 26079946 34155348
ABL1 CD19 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11120811 20841568
ABL1 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 8617726 1623525 10194451 19380743 10592173 20841568 8112292
ABL1 DOK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 11071635 10567556 12777393 9008161 15148308 15592455 25043303 18768933
ABL1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 20841568 20101225 30692633
SRC ARAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9020159
KIT CBL â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11994499 16780420 12444928 17904548
CRK CBL â—¼   PHYSICAL_INTERACTION 9.0 1.0 ACSN 11353765 15169881 15308668 16000375 16076871 18835194 19454690 20189481 22464172
CRKL CBL â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 10426994 11062502 11353765 11385609 11447289 11526404 11579131 11687500 11907067 12670391 15169881 15308668 15536084 16000375 16076871 16713974 17397400 18250477 18287025 18835194 19109239 19454690 19909365 20189481 20805416 21149606 21826665 22464172 23087689 23523669 24751819 24795729 25960930 7682895 9314552
GRB2 CBL â—¼   PROTEIN_INTERACTION 1.0 1.0 HIPPIE 31980649 8649804 8995445 25036637 23799367 11997436 8943292 9242692 10570290 8662998 11399323 10086340 7642581 9108392 20936779 11133830 8626404 17094785 8063801 9129019 8900205 15210722 8621483 25872741 25814554 9178909 16906159 8950973 17971399 10025673 9295052 19380743 9716598 16713569 11964172 9234717 8083187 7537740 8824292 9259313 9311917 7791764 17072306 14725908 33627783 9461587 9434624 9851874 8695851 12839496 17944804 11792427 10204582 8621719 11823423 9541596 33961781 169092 11263968 98621719 28514442 18273061 7592693 9174058 21706016 8995358 9872323 9233773 9367879 7544353 12941616 10829062 20124286 917890 15677445 9092538 10521482 8647120 19836242
CRKL CBL â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 10426994 11062502 11353765 11385609 11447289 11526404 11579131 11687500 11907067 12670391 15169881 15308668 15536084 16000375 16076871 16713974 17397400 18250477 18287025 18835194 19109239 19454690 19909365 20189481 20805416 21149606 21826665 22464172 23087689 23523669 24751819 24795729 25960930 7682895 9314552
CRK CBL â—¼   SHARES_COMPLEX 9.0 1.0 ACSN 11353765 15169881 15308668 16000375 16076871 18835194 19454690 20189481 22464172
GRB2 CBL â—¼   ENZYMATIC_REACTION ✅ 26.0 1.0 ACSN 10086337 10426994 10567412 10811803 10982827 11447289 11777939 11777960 11907067 12175651 12640133 15536084 15567848 15574420 16339513 16582911 16713974 16887996 17070508 17100878 17496910 17673906 18490724 19449109 26552706 8551221
CRKL CBL â—¼   ENZYMATIC_REACTION ✅ 35.0 1.0 ACSN 10426994 11062502 11353765 11385609 11447289 11526404 11579131 11687500 11907067 12670391 15169881 15308668 15536084 16000375 16076871 16713974 17397400 18250477 18287025 18835194 19109239 19454690 19909365 20189481 20805416 21149606 21826665 22464172 23087689 23523669 24751819 24795729 25960930 7682895 9314552
SRC CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 50.0 1.0 Omnipath 9525940 7782294 16713569 18273061 10829062 10799548 10934191 12604776 9890970 17570479 9013636 15135048 17094785 25784557 8635998 10092522 12522270 8621719 17141222 16636290 11239464 19861161 11994282 12941616 14739300 22203672 8849724 15212693
FYN CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 97.0 1.0 Omnipath 9525940 7642581 8626543 7782294 15208330 16503409 16713569 10829062 10799548 10934191 8900205 8551236 8662998 8995358 19734451 12604776 9890970 10592173 17570479 10629042 17094785 10092522 11997497 12522270 15556646 12244174 8621719 9102067 22880054 9311917 11239464 19904769 11994282 12941616 9535867 25814554 12231245 15190072
INSR CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 11997497 10635327 11994282 12522270 9525940 12604776 10592173 17570479 9102067 15951569 10829062 15212693 11239464
CRK CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 60.0 1.0 Omnipath 8683103 16289966 8626543 8621483 9617486 16713569 9416834 8524328 10962563 8626404 9367879 8662998 12393469 11792427 15581361 9013636 15581362 9178909 9988765 18835194 8943292 20697350 9129019 19380743 25814554 9461587
LTK CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 9223670
LCK CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 9525940 10829062 10799548 10934191 7721825 16107303 12604776 9890970 17570479 11904433 9178909 10092522 11997497 12522270 8621719 9102067 11239464 11994282 11741956
CBL GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 158.0 1.0 Omnipath 11823423 8621483 9242692 18273061 17635922 16906159 8626404 8662998 9108392 9541596 98621719 9295052 25872741 17372273 8824292 8943292 12941616 20124286 19531499 10086340 8063801 9129019 9590251 11263968 9461587 7642581 10521482 10204582 8995445 8900205 7592693 9716598 8083187 14725908 17904548 7791764 9178909 25036637 8695851 19836242 7537740 15210722 9108316 169092 9311917 10514377 9092538 17072306 19380743 9872323 9234717 11997436 23799367 9434624 16713569 10829062 9367879 11964172 12839496 15677445 9851874 11792427 17094785 20936779 10570290 917890 17944804 25814554 17971399 11133830 8950973 21706016 8995358 9233773 10025673 8621719 11399323 9259313 9174058 8649804
CBL KIT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 9092574 17904548 25737303 8950973 15315962 17635922 10514377
CBL RET â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12727845 15677445
CBL CSF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 11847211 10025673 10648820 11850825 7782294
CBL EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 188.0 1.0 Omnipath 34609770 16105874 18273061 22239438 24797263 20332299 17635922 23158001 17545148 8662998 12604776 9890970 23153581 17182860 25872741 12593795 23175185 10092522 15107835 22266821 22833562 24714105 17242169 25140053 20124286 19531499 9756944 10086340 22203672 19225046 16729043 15282549 20562913 22394513 20940296 23331499 7592693 19713535 10635327 19836242 15465819 15210722 25521828 23897813 10514377 12734385 18508924 11994282 20877636 33323455 22976291 23774213 23027125 15159412 18255265 16246327 28541302 16849543 23799367 16713569 10799548 8798643 19155296 9121472 17486068 21772844 16969069 15677445 15962011 23418353 12803489 32714745 14505571 27903975 19578043 26177020 11239464 18319245 11408594 10428778 12061819 17995934 17971399 27059931 26055326 15735736 23457600 7782294 22591401 29629558 11370743 7657591 21071413 28198003 18316398 19947936 9130710 18271526 15657067 31182136 16923119 17880946 32904620 15117950 14627991 15668240 15383614
CBL MET â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 16397241 15123609 23331499 25241761 21222362 11894096 18672314 21163258 19450681 18273061 35309168 17533376 19433454 17635922 10514377
CBL ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 25102001 20332299 17635922 10514377
CTLA4 CD28 â—¼   DOWN_REGULATES ✅ - 12.0 1.0 ACSN 10921877 11093160 12370081 16227604 16885030 16916641 18292600 19890961 21159657 21376459 22116087 22437870
JAK2 CTLA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10842319 9813138 9973379
FYN CTLA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 9712716 25241761 9813138 9973379 16713569 10842319 10694513
LCK CTLA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 9712716 9813138 9398332 9973379 10842319
EGFR SHC1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 10404636 20430953 23010081 25987127 28513565
EGFR GRB2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 10404636 20430953 23010081 25987127 28513565
ESR1 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12894229 12421825 8200909 21705183
SRC EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 232.0 1.0 Omnipath 16414009 17081983 25958313 16943190 15618223 19935697 19305428 25402006 24797263 29285309 7488034 15592458 17389395 16461772 20562096 19275932 17897439 15899872 17570479 2803273 23636329 23246962 25505586 23175185 15615697 23349873 16849545 25356505 11983694 24189400 11756413 25748412 26325669 26150526 14512423 18789131 14750954 31978707 25573954 27495374 20071362 18707149 28759036 16729043 26494466 27716204 25537504 17237269 18687633 25884760 29036202 26936397 17575160 20926745 20935677 15282306 23702846 15476828 9069259 19336574 20421302 15660394 23866081 19377510 9777370 22426783 29321659 33706413 25841779 19840943 18669648 12397069 16843263 18957516 34088769 25077442 14963038 19836242 17653080 19625610 16936701 11960379 15548697 18295415 17523611 21268077 20333651 21399647 23376850 11250711 23942551 19704002 22927910 11160627 31952541 10777553 17016520 2543678 19258037 33883672 17646646 28102297 23873690 26771606 21573184 23119029 19151764 16713569 7797556 25955608 15302935 20407013 28513565 23119185 9990038 21080693 20190765 25347738 14630916 15708852 21822308 20628053 25301722 24658140 19690143 27564112 20802523 29124875 33657368 12101233 21787862 14764607 17284441 12878163 26290602 15951569 16543144 15212693 17971399 14523024 10971656 21278788 8845374 22430206 18083107 29641465 18234969 18460189 17551925 22957061 26571308 17043637 20371672 10358079 16799092 19154417 23066441 28065597 12842895 18180459 17158602 18271526 15657067 25159151 34367939 24919575 10075741 25366117 24349301 17561374 16862179 20215522 31980649 24335899 16037379 18451158 14530278 16505275 12063263 23449029 11311660
CBLB EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 17145710 19531499 11375397 10086340 12577067 10542134 17635922 10514377
JAK2 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 17389395 10635327 17081983 10358079 16273093 16799092 18691976 10459005 9363897 15284024 23838182 17016520 18669648 15302935
EGFR GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 46.0 1.0 Omnipath 19901323 15231819 16497976 25402006 17389395 20068231 23066441 11432805 9658397 19509291 18669648 10978177 10753869 10734310 11896055 18271526 24658140 10648629 11779868 31980649 15212693 9890893 17016520
EGFR CRKL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 31980649 23397142 18271526 24658140 25402006 16729043
EGFR GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 109.0 1.0 Omnipath 9544989 10595738 23956138 27059931 10026169 16273093 11726515 24697349 21596750 19289468 7518560 21706016 23799367 9050991 16317285 16713569 25402006 11370743 24797263 8647858 8887653 9416834 21278786 16799092 8662998 10229072 11896612 7592693 19509291 8810325 24189400 19836242 11960376 7506413 18271526 15657067 10085134 24658140 17242169 7510700 8940013 7650032 8810340 11084343 12577067 7527043 31980649 11408594 19531499 20124286 23178716 9886492 23181695 9020117 8479540 14679214 12648464 1322798 17991782 16729043 17971399
EGFR ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 20809984 17284441 16713569 11887937
EGFR ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 17145710 23436906 7929151 21278786 24189400 23866081 17148612 12648464 27756321 18803307 10527633 10572067 22439932
EGFR ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 65.0 1.0 Omnipath 17081983 16207817 21044682 17148612 24557338 16713569 21203579 10233167 20471394 17389395 17486068 21278786 11500516 11279155 11500850 17426253 16843263 19650109 25241761 24189400 15657067 17307140 18803307 1706616 12354693 10572067 24355130 11408594 19060928 12648464 16516204 15951569 23436906 20211985
EGFR SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 78.0 1.0 Omnipath 9544989 8808684 10595738 23956138 9388490 11350724 16273093 7542991 7681824 7518560 9710588 23799367 16713569 25402006 11370743 24797263 9742218 20935677 8887653 8034616 23331499 8662998 7542744 10049786 28065597 9130710 10635327 24189400 7506413 18271526 15657067 24658140 8810340 12577067 11196191 10766863 23178716 31980649 35384245 11408594 19531499 9756944 26551075 1623525 15951569 16729043 17956904
EGFR CRK â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 52.0 1.0 Omnipath 10595738 9480991 16273093 9617486 25402006 17399949 8662907 8875975 21602891 20068231 8194526 12198159 9642287 11956190 24658140 26656091 9480911 31980649 15212693 26473374 16729043 17016520
EGFR SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9544989 19531499 9447973 16713569 12577067
FGFR1 GRB2 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 17505008 18757403 21666749 11689702 11739186 18381441 19809159 21160078 14534538 15448205
IRS1 GRB2 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 8316835 8810325 9832424 8621421 8530377 9852124 9003010
GRB2 GAB1 â—¼   PHYSICAL_INTERACTION 50.0 1.0 ACSN 10086337 10514377 10567412 10648629 10811803 10982827 11062502 11313945 11385609 11447289 11777939 11907067 11940581 12040186 12175651 12419216 12640133 12670391 12782630 14585353 15199124 15534002 15536084 15567848 15574420 15584861 15863030 16102570 16227978 16488589 16582911 16847462 16887996 17496910 17635922 17673906 18287025 19449109 19568798 19615955 20805416 21102635 23523669 24027568 26552706 27111285 7510700 8294866 8551221 9779982
GRB2 CRKL â—¼   PHYSICAL_INTERACTION 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
GRB2 CRK â—¼   PHYSICAL_INTERACTION 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
GRB2 RAC1 â—¼   PHYSICAL_INTERACTION 32.0 1.0 ACSN 10086337 10567412 10811803 10982827 11274345 11447289 11756498 11777939 12040186 12175651 12640133 12738796 14585353 15567848 15574420 15863030 16102570 16582911 16887996 17496910 17673906 18000759 18855897 19151919 19449109 19568798 21614932 24027568 26552706 27331412 7510700 8551221
GRB2 LAT â—¼   PHYSICAL_INTERACTION 51.0 1.0 ACSN 10072481 10086337 10209041 10567412 10781611 10811803 10925299 10982827 11169415 11447289 11532940 11777939 11994416 12175651 12640133 1281218 12845332 14764585 15214048 15567848 15574420 16102570 16329184 16582911 16887996 1712101 17397400 17496910 17673906 19449109 19494291 19909365 23523669 23620508 24584707 25137453 2536067 25456276 25960930 26552706 7523143 7682895 7890616 8226994 8551221 8649391 8976179 8995379 9489702 9535722 9846483
GRB2 CD28 â—¼   PHYSICAL_INTERACTION 23.0 1.0 ACSN 10086337 10209041 10567412 10811803 10982827 11447289 11777939 12175651 12640133 1313950 15197224 15567848 15574420 16582911 16887996 17496910 17673906 19449109 22437870 26552706 7523569 8551221 9359474
GRB2 SHC1 â—¼   PHYSICAL_INTERACTION 69.0 1.0 ACSN 10022831 10086337 10358164 10567412 10811803 10849428 10982827 11166270 11283723 11335727 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15308668 15501236 15520864 15567848 15573129 15574420 15863030 16000375 16002046 16076871 16102570 16212621 16530705 16572188 16582911 16887996 17086423 17496910 17673906 17883421 18835194 19223473 19414323 19449109 19454690 19909365 21372296 21378271 22064427 22461508 22464172 23390297 23896411 24027568 24217602 24346288 24670066 25922287 26201938 26552706 7510700 8551221 8837607 9157999 9570538 9753319 9763606
SOS1 GRB2 â—¼   PROTEIN_INTERACTION 1.0 1.0 HIPPIE 28514442 16520382 31980649 32062451 8493579 21988832 14679214 7510700 7514169 21706016 10319320 32203420 9872323 9797459 34407391 16906159 10716926 12577067 8810325 7629168 11960376 7664271 8626525 15192046 7629138 11997436 8943292 10207103 8695800 10570290 10025673 8112292 11726515 8816480 20473329 7559490 7773779 9447984 19380743 7642581 7527391 9716598 9344843 10477741 16713569 19323566 7516467 17474147 9569023 8188688 16893902 11964172 9478994 33961781 8479541 28166272 9009162
GRB2 LAT â—¼   PROTEIN_INTERACTION 51.0 1.0 ACSN 10072481 10086337 10209041 10567412 10781611 10811803 10925299 10982827 11169415 11447289 11532940 11777939 11994416 12175651 12640133 1281218 12845332 14764585 15214048 15567848 15574420 16102570 16329184 16582911 16887996 1712101 17397400 17496910 17673906 19449109 19494291 19909365 23523669 23620508 24584707 25137453 2536067 25456276 25960930 26552706 7523143 7682895 7890616 8226994 8551221 8649391 8976179 8995379 9489702 9535722 9846483
GRB2 SHC1 â—¼   PROTEIN_INTERACTION 69.0 1.0 ACSN 10022831 10086337 10358164 10567412 10811803 10849428 10982827 11166270 11283723 11335727 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15308668 15501236 15520864 15567848 15573129 15574420 15863030 16000375 16002046 16076871 16102570 16212621 16530705 16572188 16582911 16887996 17086423 17496910 17673906 17883421 18835194 19223473 19414323 19449109 19454690 19909365 21372296 21378271 22064427 22461508 22464172 23390297 23896411 24027568 24217602 24346288 24670066 25922287 26201938 26552706 7510700 8551221 8837607 9157999 9570538 9753319 9763606
GRB2 RAC1 â—¼   SHARES_COMPLEX 32.0 1.0 ACSN 10086337 10567412 10811803 10982827 11274345 11447289 11756498 11777939 12040186 12175651 12640133 12738796 14585353 15567848 15574420 15863030 16102570 16582911 16887996 17496910 17673906 18000759 18855897 19151919 19449109 19568798 21614932 24027568 26552706 27331412 7510700 8551221
GRB2 GAB1 â—¼   SHARES_COMPLEX 50.0 1.0 ACSN 10086337 10514377 10567412 10648629 10811803 10982827 11062502 11313945 11385609 11447289 11777939 11907067 11940581 12040186 12175651 12419216 12640133 12670391 12782630 14585353 15199124 15534002 15536084 15567848 15574420 15584861 15863030 16102570 16227978 16488589 16582911 16847462 16887996 17496910 17635922 17673906 18287025 19449109 19568798 19615955 20805416 21102635 23523669 24027568 26552706 27111285 7510700 8294866 8551221 9779982
GRB2 CD28 â—¼   SHARES_COMPLEX 23.0 1.0 ACSN 10086337 10209041 10567412 10811803 10982827 11447289 11777939 12175651 12640133 1313950 15197224 15567848 15574420 16582911 16887996 17496910 17673906 19449109 22437870 26552706 7523569 8551221 9359474
GRB2 CRKL â—¼   SHARES_COMPLEX 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
GRB2 CRK â—¼   SHARES_COMPLEX 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
FYN GRB2 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 9822663 15886116 10849438 12670394
LCK GRB2 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 10652356 11062502 12731048 12740575 15536084 17544292 19290918 20814939 21127503 22513334 23620508 8478617 8986721 9438848 9738502 9751747
IRS1 GRB2 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 10086337 10826997 12175651 12444011 12767520 16931767 17604717 19030972 21540285 22465479 24036369 8621421
GRB2 GAB2 â—¼   ENZYMATIC_REACTION ✅ 25.0 1.0 ACSN 10086337 10358164 10567412 10811803 10849428 10982827 11447289 11449354 11777939 12175651 12393695 12640133 15567848 15574420 16076871 16212621 16582911 16887996 17496910 17673906 19449109 19909365 26552706 8551221 9763606
GRB2 SHC1 â—¼   ENZYMATIC_REACTION ✅ 69.0 1.0 ACSN 10022831 10086337 10358164 10567412 10811803 10849428 10982827 11166270 11283723 11335727 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15308668 15501236 15520864 15567848 15573129 15574420 15863030 16000375 16002046 16076871 16102570 16212621 16530705 16572188 16582911 16887996 17086423 17496910 17673906 17883421 18835194 19223473 19414323 19449109 19454690 19909365 21372296 21378271 22064427 22461508 22464172 23390297 23896411 24027568 24217602 24346288 24670066 25922287 26201938 26552706 7510700 8551221 8837607 9157999 9570538 9753319 9763606
GRB2 LAT â—¼   ENZYMATIC_REACTION ✅ 51.0 1.0 ACSN 10072481 10086337 10209041 10567412 10781611 10811803 10925299 10982827 11169415 11447289 11532940 11777939 11994416 12175651 12640133 1281218 12845332 14764585 15214048 15567848 15574420 16102570 16329184 16582911 16887996 1712101 17397400 17496910 17673906 19449109 19494291 19909365 23523669 23620508 24584707 25137453 2536067 25456276 25960930 26552706 7523143 7682895 7890616 8226994 8551221 8649391 8976179 8995379 9489702 9535722 9846483
GRB2 GAB1 â—¼   ENZYMATIC_REACTION ✅ 50.0 1.0 ACSN 10086337 10514377 10567412 10648629 10811803 10982827 11062502 11313945 11385609 11447289 11777939 11907067 11940581 12040186 12175651 12419216 12640133 12670391 12782630 14585353 15199124 15534002 15536084 15567848 15574420 15584861 15863030 16102570 16227978 16488589 16582911 16847462 16887996 17496910 17635922 17673906 18287025 19449109 19568798 19615955 20805416 21102635 23523669 24027568 26552706 27111285 7510700 8294866 8551221 9779982
GRB2 LCP2 â—¼   ENZYMATIC_REACTION ✅ 26.0 1.0 ACSN 10086337 10426994 10567412 10811803 10982827 11447289 11777939 11777960 11907067 12175651 12640133 15536084 15567848 15574420 16339513 16582911 16713974 16887996 17070508 17100878 17496910 17673906 18490724 19449109 26552706 8551221
GRB2 FYN â—¼   DOWN_REGULATES ✅ - 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
ERBB2 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 31980649 9756944 21278786 16273093 24189400 11173924 9710588 24658140 11606575 14967450 17875712 16713569 16729043
SHC1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 198.0 1.0 Omnipath 8808684 9083103 8551221 9126968 8621483 25416956 9252386 8524223 7535773 8662998 11302736 11827484 8995379 9541596 9175774 10207047 7717978 17673906 7744881 11505033 10523831 24189400 9927207 7650032 8810340 9045692 23178716 19531499 15812354 9129019 10356320 12485888 9461587 8114695 7514169 9566877 8939605 16371368 15341520 7529871 10891441 10749687 7524086 26645482 8491186 10592173 10049786 9171350 11707404 7537740 15688026 8663178 19380743 11782427 9544989 16436051 9434624 16713569 21725358 11964172 17314098 11792427 8195171 1465135 12213123 8647288 12955078 10477741 11707405 12577067 9199344 10080542 8112292 7760801 10570290 11997181 7798267 16520382 10961885 8950973 21706016 9448048 8662733 11370743 8051109 9733714 8621475 9254595 8294403 10748054 8621719 8940013 12441060 22057045 7505797 24737791 20697350 9886492 18174162 18273058 8235613 7963520 7523859
MET GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9660480 15546961 22128289 12475979 11063574 7511210 11439336 8662889
CD28 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 18829987 8576157 9694876 24098653 27927989 21487479 7737275
RET GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9393871 16189514 15677445
LAT GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 11368773 9489702 10811803 8063801 17043143 16938345 16713569 23150273 12186560 16906159
ERBB3 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 9756944 24189400 11173924 24658140 14967450 16729043
IRS1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 8265614 7862167 11788580 8388384 8491186 8536716 7488107 7486683 10358772 10592173 8196603 12173038 12679424 8114695 11259577 8810325
NTRK1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11733534 10748052
CBLB GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 31.0 1.0 Omnipath 10022120 25416956 21706016 31467278 32814053 9614102 17635922 11375397 8626404 16189514 21900206 20936779 27107012 12577067 10514377 19531499 10086340 29997244
CSF1R GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9178909 9380408 10025673 8262059
LCP2 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 7706237 20936779 10224278 8695800 17235283 15929943 25416956 19380743 9716598 32296183 10204582 11314042 8995445
KIT GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 24728074 8950973 7523381 10022833 7523859 8647802 16713569 17452978 17904548 10377264
JAK2 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8536716 8950973 7500025 17474147 19273609
IRS2 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 7559579 11788580 10358772 11305324 9852124
SRC GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 12624098 11964172 9016807 16713569 26103942 20554525
GRB2 GAB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 37.0 1.0 Omnipath 17145710 16371368 25416956 21706016 15143164 10391903 19172738 10913131 11027663 9973481 10973965 20936779 10068651 11882361 32296183 16199887 24737791 15010462 19523899 16253990 19380743 31515488 11782427
GRB2 GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 47.0 1.0 Omnipath 12766170 21706016 9242692 10913131 11445578 22536782 8596638 11027663 10592173 20936779 11960376 15010462 19523899 20005866 19380743 10871282 9804835 14685170 11314042
GRB2 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 145.0 1.0 Omnipath 9544989 9872323 7642581 15746962 11726515 8621483 23334917 16520382 11997436 21706016 10359574 8950973 7664271 16713569 16893902 16906159 21988832 19323566 9009162 10716926 11964172 7629168 9815779 10592173 9716598 8647802 28166272 7773778 7773779 18778683 8188688 10319320 8810325 9344843 23452850 11960376 8816480 10025673 7510700 8940013 12955078 9697839 12345678 10477741 8493579 8943292 12577067 7862167 9199344 8112292 7898932 10207103 8695800 19531499 10570290 7760801 20005866 19380743 9447984 8235613 8479540 7527391 14679214 8479541 17474147 7514169 7629138
RAC1 NISCH â—¼   UP_REGULATES ✅ + 11.0 1.0 ACSN 11121431 11274345 11544274 11756498 15157156 15229651 18000759 19151919 24459205 27331412 9655398
MET CRKL â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 10871282 12138161 11146548 10753869 10618718
CRK CRKL â—¼   PHYSICAL_INTERACTION 84.0 1.0 ACSN 10022831 10086337 10426994 10567412 10811803 10849428 10982827 11062502 11166270 11335727 11353765 11385609 11447289 11449354 11526404 11532940 11579131 11687500 11777939 11907067 11960372 12175651 12393695 12629515 12640133 12670391 13678960 15099563 15111329 15169881 15308668 15501236 15520864 15536084 15567848 15573129 15574420 16000375 16002046 16076871 16530705 16572188 16582911 16713974 16887996 17086423 17397400 17496910 17673906 17883421 18250477 18287025 18835194 19109239 19414323 19449109 19454690 19909365 20189481 20805416 21149606 21372296 21826665 22064427 22461508 22464172 23087689 23390297 23523669 24217602 24346288 24751819 24795729 25922287 25960930 26201938 26552706 7682895 8551221 8837607 9157999 9314552 9570538 9753319
SHC1 CRKL â—¼   PHYSICAL_INTERACTION 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
CRK CRKL â—¼   SHARES_COMPLEX 84.0 1.0 ACSN 10022831 10086337 10426994 10567412 10811803 10849428 10982827 11062502 11166270 11335727 11353765 11385609 11447289 11449354 11526404 11532940 11579131 11687500 11777939 11907067 11960372 12175651 12393695 12629515 12640133 12670391 13678960 15099563 15111329 15169881 15308668 15501236 15520864 15536084 15567848 15573129 15574420 16000375 16002046 16076871 16530705 16572188 16582911 16713974 16887996 17086423 17397400 17496910 17673906 17883421 18250477 18287025 18835194 19109239 19414323 19449109 19454690 19909365 20189481 20805416 21149606 21372296 21826665 22064427 22461508 22464172 23087689 23390297 23523669 24217602 24346288 24751819 24795729 25922287 25960930 26201938 26552706 7682895 8551221 8837607 9157999 9314552 9570538 9753319
SHC1 CRKL â—¼   SHARES_COMPLEX 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
FYN CRKL â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 10591186 10648627 11062502 12218089 12731048 15536084 19290918 19909365 20814939 21378271 22683124 22863785 24440149 27192565 9738502
CRK CRKL â—¼   ENZYMATIC_REACTION ✅ 84.0 1.0 ACSN 10022831 10086337 10426994 10567412 10811803 10849428 10982827 11062502 11166270 11335727 11353765 11385609 11447289 11449354 11526404 11532940 11579131 11687500 11777939 11907067 11960372 12175651 12393695 12629515 12640133 12670391 13678960 15099563 15111329 15169881 15308668 15501236 15520864 15536084 15567848 15573129 15574420 16000375 16002046 16076871 16530705 16572188 16582911 16713974 16887996 17086423 17397400 17496910 17673906 17883421 18250477 18287025 18835194 19109239 19414323 19449109 19454690 19909365 20189481 20805416 21149606 21372296 21826665 22064427 22461508 22464172 23087689 23390297 23523669 24217602 24346288 24751819 24795729 25922287 25960930 26201938 26552706 7682895 8551221 8837607 9157999 9314552 9570538 9753319
BCR CRKL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 26500649 8978305 15143164
GAB1 CRKL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 10753869 25241761 24728074 31585087 10871282 10592173 23397142
CRKL GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 10753869 25241761 24728074 31585087 10871282 10592173 23397142
RAC1 LCP2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17540168 11278486 11804587 12670394
CD28 LCP2 â—¼   ENZYMATIC_REACTION ✅ 23.0 1.0 ACSN 10086337 10209041 10567412 10811803 10982827 11447289 11777939 12175651 12640133 1313950 15197224 15567848 15574420 16582911 16887996 17496910 17673906 19449109 22437870 26552706 7523569 8551221 9359474
LAT LCP2 â—¼   ENZYMATIC_REACTION ✅ 51.0 1.0 ACSN 10072481 10086337 10209041 10567412 10781611 10811803 10925299 10982827 11169415 11447289 11532940 11777939 11994416 12175651 12640133 1281218 12845332 14764585 15214048 15567848 15574420 16102570 16329184 16582911 16887996 1712101 17397400 17496910 17673906 19449109 19494291 19909365 23523669 23620508 24584707 25137453 2536067 25456276 25960930 26552706 7523143 7682895 7890616 8226994 8551221 8649391 8976179 8995379 9489702 9535722 9846483
GAB2 LCP2 â—¼   DOWN_REGULATES ✅ - 6.0 1.0 ACSN 10849428 10982827 11572860 12640133 16212621 19909365
FYN LCP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10648627 9047237
GAB2 LCP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15286727 23109003 12640133 11323691
LCK LCP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 16354835 21725281 8702662 10648627 10556826
SHC1 CRK â—¼   PHYSICAL_INTERACTION 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
SHC1 RAC1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17540168 11278486 11804587 12670394
SHC1 CRK â—¼   SHARES_COMPLEX 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
LAT SHC1 â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 10072481 10781611 10811803 11169415 12640133 14764585 16102570 16329184 19494291 19909365 23620508 25137453 7523143 7890616 8649391 8976179 9489702 9535722
IGF1R SHC1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 10086337 10826997 12175651 12444011 12767520 16931767 17145802 19030972 21540285 24103846 24782617
SHC1 GAB2 â—¼   ENZYMATIC_REACTION ✅ 25.0 1.0 ACSN 10086337 10358164 10567412 10811803 10849428 10982827 11447289 11449354 11777939 12175651 12393695 12640133 15567848 15574420 16076871 16212621 16582911 16887996 17496910 17673906 19449109 19909365 26552706 8551221 9763606
SHC1 FYN â—¼   DOWN_REGULATES ✅ - 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
RET SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 9393871 23331499 9047384 15677445 16189514 9047383 8183561
ERBB2 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 28065597 23331499 9756944 16273093 8026468 9710588 10085134 24658140 9590694 16713569 16729043 16843263
CBLB SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 19531499 11375397 16189514 9614102 12577067
IRS1 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 9202037 10807918 7499194
ERBB3 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 9694850 9756944 16273093 24189400 8026468 24658140 9590694 16189514 16729043
GAB2 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 8995358 10704825
LCK SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 74.0 1.0 Omnipath 19901323 20230923 16497976 9121430 15592455 9446569 17389395 18578522 10921922 10482988 10764799 18452278 20068231 18669648 12522270 9685404 10896916 9927207 12237775 8702728 8610109 19651622 9741627 9710204 19664994 17016520 10816433 11075717
FYN SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 96.0 1.0 Omnipath 19901323 20230923 16497976 9121430 15592455 16713569 9446569 17389395 23331499 18578522 10921922 10482988 10764799 18452278 20068231 10592173 18669648 12522270 9685404 10896916 7516469 9927207 12237775 8702728 8610109 19651622 9741627 9710204 19664994 17016520 10816433 11075717
IGF1R SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 12767520 15629149 7541045 17145710 8776723 7559507 14764897 17570479 16113100 24051437 17673906
NTRK1 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 8155326 9715270 8226808 15056278 10708759 8552402 9856458 23331499 10629055 10092678 12446789 8524391 25921289 7541035 8183561
MET SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 9083103 11687594 9660480 14990987 24728074 8084588 8939605 8947042 7731718 11884620 15688026 14685170
LTK SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 9223670
JAK2 SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9126968 7535773
SRC SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 55.0 1.0 Omnipath 19901323 9388490 8939605 9096689 10971656 16497976 15592455 9121430 10891441 17389395 11687594 10329689 10482988 20068231 17570479 16189514 9685404 23109003 7516469 9927207 18840094 15688026 15212693 1409579 14963047 9710204 26551075 17016520 11075717
INSR SHC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 93.0 1.0 Omnipath 9083103 17145710 19901323 10803466 20230923 16497976 9121430 15592455 9446569 17389395 18578522 7559507 7537849 10482988 10764799 10921922 18452278 20068231 10592173 7499194 18669648 15629149 12522270 9685404 10896916 9927207 9593725 12237775 8702728 8610109 19651622 15212693 9741627 9710204 19664994 7685165 8626723 17016520 10816433 11075717
SHC1 DOK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11071635
SHC1 SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 9544989 8631299 8621483 8950973 10891441 10783152 9278309 17673906 9344843 8294403 8021500 10025673 7520523 12955078 12577067 9199344 19531499 7760801 10570290 19380743 8235613 10675333 8114695
SHC1 GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 11707404 14982882 24728074 10871282 10194437 9804835 12808090
RET CRK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9393871 10208419 25241761
IRS1 CRK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9837978 8810325 8621590
CBLB CRK â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 8626404 19380743 12697763 25814554
IGF1R CRK â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 17145710 12198159 9642287 9480991 9480911 20068231 11956190 8194526 8875975 15522217 17016520
NTRK1 CRK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 7657647 8552402 12446789 7509449
CRK GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 24728074 20619534 12138161 19380743 11146548 10592173 19350053 16713569 10618718
LCK FYN â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 9822663 15886116 10849438 12670394
LCK ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 9500442 10571988 25386784 11145737 7539106 27748765
LCK LAT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16938345 12359715 12186560 27700984
LCK CD3E â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 12522270 2470098 15144186 11855827 15592455 16094384 15659558
LCK DOK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 16537894 10799545 11841937 11489946
LCK KIT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17570479 9788619 24728074
LCK CD28 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 7568038 22936936 27460989 16094384 10430626 8992971
LAT RAC1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17540168 11278486 11804587 12670394
FYN CD28 â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 10591186 10648627 12218089 12731048 19290918 19909365 20814939 21378271 22683124 22863785 24440149 27192565 9738502
CBLB FYN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 15208330 16503409 32296183 25814554 8083187
FYN KIT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9038210 9799234 12374739
FYN SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17474147 16713569 9856337
FYN DOK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11489946 16537894 11841937 11825908 15345598
FYN GRB10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 10871840 16713569
SRC JAK2 â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 11476890 12094222 16919435 17496910 17517963 25572304 26552706 27216177
JAK2 IRS2 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23390297 24030977 24091328 27216177 2965306 7512720 7521688 9834059
SOCS1 JAK2 â—¼   DOWN_REGULATES ✅ - 6.0 1.0 ACSN 10485906 12193701 12223527 12811837 21469115 23124025
KIT JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 8611693 7527392 15526160 9355737
IRS1 JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 9492017 7782332 11208867 21071413 12960006 15316008
GHR JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 8063815 23331499 10502458 17312100 21347402 18988627 7540178 9211920
SOCS1 JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 10421843 23331499 21071413 10455112 14522994 10064597 28258213 19287004 18508766 11314018 18988627 11971965 11713228 10975987 9202126 9344848
JAK2 GAB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18644434 21183952
JAK2 EPOR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 10660611 12441334 7559499 8343951 18672044 11779507 12027890 11443118 12524467 9030561 9573010 15212693 10579919
KIT GRB10 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 16129412 10377264 11809791 9872323 8647802
CBLB KIT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 15315962 12177062 17635922 10514377
SRC KIT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 12878163 7520444 10523831
KIT GRB10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11809791
KIT DOK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11071635 11825908
KIT SOCS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10022833
RAC1 AKT1 â—¼   ENZYMATIC_REACTION ✅ 45.0 1.0 ACSN 10722653 10949026 11274345 11715018 11756412 11756498 11923280 12408816 12906785 15169778 15808505 16469695 16697215 17052453 17461779 17680028 18000759 18372248 18492954 18570873 18636226 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20138985 20214616 20338997 20398329 20832730 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9812896
SRC RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22163037 17991704 21798346 26816343 29036929
RAC1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 34.0 1.0 Omnipath 18000759 20027184 21157483 11756412 11923280 16697215 20398329 17461779 18372248 20338997 15808505 20138985 20214616 21474067 19568798 15169778 19720745 18925875 10949026 11715018 19143635 12393431 18636226 10617634 9812896 17680028 19151919 10722653 20832730 18570873 17052453 12408816 11274345
SRC CDC42 â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 11476890 12094222 16919435 17496910 17517963 25572304 26552706 27216177
ERBB2 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16769082 19617202 11940572 12753909 21075308 7542762
SRC CDC42 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 14506284 26816343 9626657
SRC SOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17474147 9856337
SRC GRB10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 10871840
SRC GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 26706435 15574420 19881549 12941962 21442024 12808090
SRC MET â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 24728074 24034250 9837958 17570479
SRC RET â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11713247 17570479 16189514 10070972
SRC IGF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 17389395 15212693 18691976 7559478 7493944 7537849 20068231 23472139 8550552 17016520 8940173 9480911
SRC ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 15784253 25364741 17400812 16957778 17627277 15140878 11032808 23065768 12736255 7539106 17921256 27472465 14963108 24487689 25275301 12630920 22865929 14766010 30148069 11013076 15020686 9500442 17284441
SRC GAB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10391903 12464621 11640929 9885561
SRC AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 11445557 25241761 23242524 18283331 12600984
AKT1 GAB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 11782427
FGFR1 SOS1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11353842 8780727 11447289 7559490 9182757
IRS1 SOS1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 8316835 8810325 9832424 8621421 8530377 9852124 9003010
IGF1R IRS1 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 10086337 10826997 11274345 12175651 12444011 12556535 12655147 12767520 16931767 17145802 17673906 19030972 21540285 24103846 24782617
AKT1 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17570479 17640984 10497255
INSR IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 64.0 1.0 Omnipath 17145710 10655627 7651388 25472611 1385403 18083107 12220227 23331499 28328746 7504175 19534553 7499194 7537849 7935368 11572799 11781100 10592173 17570479 17575262 18988627 12446583 15629149 10455177 15870194 11416002 12101187 17167487 8530377 8626379 8662806 11606564 2159922 8626723 16020478 16582879
IGF1R IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 44.0 1.0 Omnipath 7541045 12444011 19030972 10082579 16931767 21798082 12220227 11259577 12767520 10826997 23331499 17827393 7504175 21071413 7559507 11572799 27856640 12175651 17570479 15829723 18988627 15629149 11557037 20670944 8530377 21540285 8776723 25886138 8662806
ESR1 IGF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17170218 20021813 16087727 19250214 10982795 24281069 18414489 15595626
IGF1R IRS4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 9553137 18988627 11316748
IGF1R GRB10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 19165858 8776723 8764099 8621530 12697834 9506989
IGF1R IRS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 8662806 9852124 10471495
ESR1 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11029009 15569929 18450422 20664923 15496458
GRB10 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11809791 15722337
RET AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12600984 15994200
AKT1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 18521086 26944939 11108261 17627277 20101208 17570479 15604293 23169992 26554417 16452229 15193262 7838153 12374744 11139588 26272591 11432835 20179234 11507039 9528769
INSR IRS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 19901323 7629118 9195949 18083107 23331499 19534553 7537849 17570479 18988627 7675087 11584304 7526222 12101187 8626379 8662806 8626723
INSR DOK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 9008160 19901323 15212693 19481264 19690332 16497976 15592455 16094384 10688886 16153436 11551902 12087092
INSR GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 10753869 10978177 17389395 19881549 10734310 20068231 9890893 9658397 16497976 26929352 17016520 18669648 11323411
INSR GRB10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 9506989 15664450 10871840 8621530 9006901 19648926 7479769 12783867 12493740
RET GRB10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 7665556 8631863
ESR1 ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 24559156 16115928 16467118 17992604 19915977 15199112 21127199 21761336 21907803 20551150 11713584 1358436 20629094 18768663 19005469 9242384 20889718 10698518 16467117
ERBB2 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 15173068
ERBB2 ERBB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 44.0 1.0 Omnipath 17145710 23680147 17148612 24557338 19411071 21203579 7592681 23688700 23331499 21278786 12648465 22806884 27531070 17570479 30898150 29066975 17426253 16843263 9130710 20227043 25241761 10799311 8816440 22733765 10572067 19060928 11173924 21075308 23436906 7538656 15504738
RET DOK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 19901323 23331499 10688886 16497976 15592455 16094384 12087092 11551902 16153436
MET GAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 10978177 17389395 19901323 10753869 15574420 15212693 10913131 10734310 11896055 20068231 10995442 9890893 16497976 14685170 17016520 18669648 11779868