Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
EGFR ARF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24797263 20029029
RHOG VAV3 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 18589439 8990121
RHOA VAV3 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 18589439 8990121
B2M RAB9A â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
HRAS BLZF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CANX CISD2 â—¼   COLOCALIZATION 2.0 0.8 intact 20010695 7712851
EGFR HRAS â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
EGFR HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 17673906
EIF2AK3 SLC7A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19029953
FSCN1 RAB1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
PTPN2 GJA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24849651
GOLGA4 TSC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
RASA1 HRAS â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5221569 9219684
PTPN2 ITGA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15592458 8284715
PTPN2 ITGA1 â—¼   COLOCALIZATION 2.0 0.8 intact 15592458 8284715
ITGA1 PTPN2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15592458
TRIO RAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18212043 18066058
TGFBR1 RHOA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19726546 15761153
VTI1B STX8 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
CAV2 EGFR â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
ATP6AP2 VMA21 â—¼   PHYSICAL_INTERACTION 806.0 0.8 STRING 36370105
ARHGDIA RAC1 â—¼   GTPASE_REACTION ✅ - 0.81 0.81 Signor 20696765
ARF6 NCLN â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 34079125 17353931
TMEM9 STX6 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 32296183
BET1 STX6 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 29568061 33961781
CD97 BET1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
STIM2 CISD2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
ELMO3 DOCK5 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
TMX1 EPHA7 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
RAC1 FAT1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31871319 31980649
RHOA FAT1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31871319 31980649
ICAM1 GIT2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
MMGT1 GOSR2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 32296183 27342126
PTPRF RHOA â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31871319 25458010
RAB1A RAB2A â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 26344197 34079125
RAB2A RAC1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31871319 26344197
CDH2 CTNNA1 â—¼   PHYSICAL_INTERACTION 822.0 0.82 STRING 36370105
CXCR4 ITCH â—¼   PHYSICAL_INTERACTION 823.0 0.82 STRING 36370105
STX18 BET1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
HMOX2 CISD2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
TRIO RHOG â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 31871319 25065758 32203420
VTI1B STX18 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
VTI1B VPS45 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
MAGT1 STT3B â—¼   CORRELATES + 0.83 0.83 CCLE 31978347
DAAM1 RHOA â—¼   PHYSICAL_INTERACTION 833.0 0.83 STRING 36370105
BET1 GOSR2 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
SNX2 EGFR â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 24797263 9819414
RAC1 TRIO â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
DLG1 KCNJ12 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
DLG1 KCNJ12 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
RAB11B RAB8A â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
AAAS NDC1 â—¼   CORRELATES + 0.84 0.84 CCLE 31978347
LAMTOR2 LAMTOR3 â—¼   CORRELATES + 0.85 0.85 CCLE 31978347
ARF6 RAB1A â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 22939626 34079125
VAV3 EGFR â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 24797263 22973453 10938113 25754235 11094073
STX6 STX18 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 26186194 34079125
EGFR PTPRF â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 24189400 24797263 31980649
TRIO PTPRF â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 27880917 8643598
EGFR VAV3 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
ATP6AP2 TMEM199 â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
IL6ST JAK1 â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
VAV3 RHOA â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 10523675 32203420
VTI1B STX6 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 27791468 26186194 28514442 34079125
RASA1 CAV2 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 12091389 15504032
MMGT1 EMC10 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 26496610 27342126 32439656 22119785
RHOA ITPR1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 12766172 31871319
RAB11B RAB1A â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
GOSR2 STX6 â—¼   PHYSICAL_INTERACTION 889.0 0.88 STRING 36370105
EGFR ARF6 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 34079125 24797263 31980649 20029029
STX6 VPS45 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 26186194 34079125
PTPRJ EGFR â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 19167335 19836242 9115287
EGFR RASA1 â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
RAB1A RAB8A â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
RAC1 IQGAP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8702968 8756646
VAV3 RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10523675 10592173
CANX B2M â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 14681859 2450918 10064069
BMPR2 ZFYVE16 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 17356069 8893010 9136927
EGFR CAV2 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 31980649 24658140 25402006 16799092 15273741
DVL3 RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 12533515
EGFR RHOA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
EGFR JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8524316 15284024
PLXNB2 HMOX2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
TRIO RHOA â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 10948190 31871319 26344197
TRIO RHOA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9464532 10948190
HLA-B B2M â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 8624811 5220994
STX6 VTI1B â—¼   PHYSICAL_INTERACTION 925.0 0.92 STRING 36370105
RAC1 ARHGDIA â—¼   PHYSICAL_INTERACTION ✅ 0.93 0.93 mint 8376617 22157745
STX8 VTI1B â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
ARHGDIA RAC1 â—¼   PHYSICAL_INTERACTION 949.0 0.94 STRING 36370105
LAMTOR3 LAMTOR2 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 8153045 21516116
NGF NTRK1 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
EMC10 MMGT1 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
HRAS RASA1 â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
VPS45 STX16 â—¼   PHYSICAL_INTERACTION 0.98 0.98 HIPPIE 28514442 12110575 32296183 33961781
STX16 VPS45 â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
B2M HLA-B â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
ARHGDIA RHOA â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
MAGT1 STT3B â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
LAMTOR2 LAMTOR3 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EGFR SCAMP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9658162
VAV3 RHOA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10523675 10592173 32203420
ARHGDIA RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 27.0 1.0 Omnipath 17245428 22157745 11368848 17353931 11513579 10346909 9490022 20696765 22393046 27173435 19961560 16189514 11513578 10673424 21900206
ARHGDIA RHOA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 10489445 20628200 11368848 17353931 9490022 9113980 25416956 20711218 16189514 15659383 14749388 11149925
RHOG ARHGDIG â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 19581409 8939998 11967128 11689693
RASA1 CAV2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12091389 23331499 15504032
HRAS CDKN2A â—¼   UP_REGULATES ✅ + 15.0 1.0 ACSN 10358164 12134164 12447393 14764585 16102570 17673906 20841469 24027568 24954210 7510700 7673236 8551221 9069260 9763606 9846483
CXCR4 RHOA â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 15261139 15882617 17035340 20535745 20644254 21521526 22025564 23034983 23402812 23567181 24277834
ITCH CXCR4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 28264927 19116316 24489825
RHOA DAAM1 â—¼   PHYSICAL_INTERACTION 53.0 1.0 ACSN 11226259 11698448 11729192 11739775 11779461 11992112 12194823 12361600 12740575 14657501 14704854 14744429 14747478 15265686 15279786 15618519 15761148 16713974 17127310 17303408 17517963 17660363 17884187 18037882 18256687 18423981 18497258 18590585 18851840 19020754 19366350 19565474 19836308 19853559 20006983 20535745 21178402 22017973 22949611 23732914 24857661 24919149 26885855 26885856 27048821 27066895 7479854 7575488 7641885 8655584 9362522 9660866 9822605
RHOA DAAM1 â—¼   SHARES_COMPLEX 53.0 1.0 ACSN 11226259 11698448 11729192 11739775 11779461 11992112 12194823 12361600 12740575 14657501 14704854 14744429 14747478 15265686 15279786 15618519 15761148 16713974 17127310 17303408 17517963 17660363 17884187 18037882 18256687 18423981 18497258 18590585 18851840 19020754 19366350 19565474 19836308 19853559 20006983 20535745 21178402 22017973 22949611 23732914 24857661 24919149 26885855 26885856 27048821 27066895 7479854 7575488 7641885 8655584 9362522 9660866 9822605
DAAM1 RHOA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 11779461 25241761 18218625 20810787 19365405
PTPN2 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 15592458 15588985 9488479 10488121 11514572 11479308
ICAM1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16799092 17145710
PTPRJ EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 19836242 9115287 19167335
EGFR RASA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 8647858 16273093 7991458 1850098 17570479 1633149 1385407
HRAS FRS2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
NTRK1 FRS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 21071413 10092678
RASA1 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 10769036 11389730 23331499 18829532 7628625 9219684 10592173 8663024 16713569 26721396 8360177 8537347 1904555 10394594 2833817
JAK1 IFNGR1 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
JAK1 IFNGR1 â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
JAK1 IFNGR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 12133952 8232552 8550631 8156998 7796299 7615558 8649432 19041276
JAK1 IL6ST â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 8390097 9238703 16051226 11943154
IL6ST JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 7896787 23331499 11468294 9388212 21220115 24710148 11742534 23663276 12487370
PTPN2 JAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 23331499 15588985 15780598 11909529
RAC1 MAP3K11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23331499 11713255 16212495 8910292 12480336 11152757 9427749
NGF NTRK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 50.0 1.0 Omnipath 17145710 8155326 9083066 11729324 27908981 22666365 17404842 24224055 25611061 14985763 9290260 9857023 28090201 12067229 23772401 10490030 11114882 27229480 1706478 11738045 10713102 9547236 1849459 9775403 17409494
PTDSS1 SCARB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12016218 8999945
RAB1A SEC23IP â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 21532587 24917561 20966969 17287728
STX16 RAB9A â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 18195106 25343031 16885419 19620288 18946081 17488291 8440258
TSC1 RAC1 â—¼   DOWN_REGULATES ✅ - 11.0 1.0 ACSN 11955434 12829230 12906785 15611338 15851026 15967165 16636147 17680028 18974095 19022819 20146692
TRIO RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9464532 8643598 10798395 32203420 10847683 11595749 21422296