Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
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Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
DVL1 APC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20224554 10330181
SMAD3 BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11906909 16603637
BAX GSK3B â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 0912742107 20080742
CCNG1 PPP2R1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219546 17245430
E2F3 CDK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8033208 7958856
HRAS CDK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
AKT1 CDKN1B â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12244303 11231573
CDKN1B RBL2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 11157749 9144196
PAX6 CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20053773 17157287
JAK2 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9209406 8400282
PLCG2 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
FYN GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9694876 7737275
PPP2R1A GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15637081 16893902
GRB2 PPP1CB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 MYL12A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 PKM â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 ANXA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 SMAD3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
GRB2 ACTN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
MAPK3 GRB2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7739560 8816480
FGFR1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9480847 16713569
PTGER4 HMOX1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
SRC MAPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16580177 9924018
F2R MAPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16580177 9924018
MAPK3 PPP2R5C â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16456541 17200115
MAPK3 CASP8 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219611 17290218
MAPK3 IRS2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7739560 8816480
MAPK3 IRS1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7739560 8816480
PPP1CA MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12624094 12840032
MAPK3 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16888388 16691505
MAPK3 GABPA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19114066
MAPK3 MAPT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19046355 9614189
MAPT AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0709180105 18292230
GSK3B MAPT â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 17078951 5219283
HLA-E PIK3R1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15536084 11907067
PIK3R1 IGF1R â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 6730400 7589433
PIK3R1 CD19 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6730437 7684160
PIK3R1 PLCG2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
PIK3R1 RAPGEF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
PIK3R1 JAK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
PIK3R1 IRS2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 23617393 8427684
EGR1 PIK3R1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11502738 15449318
GNG4 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23109003 17169327
PPP2R5C PPP2R1B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16456541 5218298
PPP2R5C PPP2R1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219546 17245430
PSEN1 ACTN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 21163940 114280
PTGER4 PSMC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
DVL3 SIRT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0911325107 20439735
JUN SIRT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22610349 23161884
SMAD3 SIRT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22610349 23161884
SIRT1 TERT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24416313 12837246
SIRT1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21775285
HRAS TADA3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TERT AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18775701 6742757
PPP1CB CDC25C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14592972 16467385
ATF4 FGF21 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22233381
GABPA RB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16738312 15618023
TCL1A JUN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0810965105 19064921
TCL1A AKT1 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
TCL1A JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19064921
ITGB1 CRKL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0807543105 19168626
JAK2 CRKL â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11443118 11124936
CRKL IRS2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11443118 11124936
ITGB1 CRKL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19168626
HEYL PPP1CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
HEYL SMAD3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SRC ITGB5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19910644 10592173
ITGB5 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19910644 10592173
JUN AREG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22570239 20308529
EGR1 AREG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20190820 20103632
ITGB3 ITGAV â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5214491 11546839
TNC ITGAV â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9314546 32196115
PDGFB RAPGEF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9546424 9739761
JUN PDGFB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10506481 9488709
SMAD3 PDGFB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16308570 10828062
EGR1 PDGFB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12384981
PDGFB SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15845350 12753909
PAX6 ITGB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10954416
FN1 ITGB1 â—¼   COLOCALIZATION 2.0 0.8 intact 21985969 8208414
SRC FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219079 16966330
FYN AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
FYN IL3RA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
FYN RAPGEF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
SMAD3 CHUK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0712044105 18268325
SMAD3 PPP2R1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD3 ITGA11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19913614
SMAD3 FGF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17637743 25374926
SMAD3 TNC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15001984
EIF4E SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12150994 23331499
JAK2 PLCG2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15644415 8034732
JAK2 RAPGEF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11443118 11124936
JAK2 IRS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15316008 17565041
SRC JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17570479 17158356
JAK2 IRS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15316008 12960006
EGR1 TGFB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12384981
TGFB1 SPARC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16189514 15034927
HRAS SRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12695509 5216326
ITGA4 ITGB7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 12626562 19454690
ITGA4 ITGB7 â—¼   PROTEIN_INTERACTION 2.0 0.8 ACSN 12626562 19454690
ITGA6 ITGB4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 19161977 22118458
ITGA6 ITGB4 â—¼   PROTEIN_INTERACTION 2.0 0.8 ACSN 19161977 22118458
FZD4 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 27096005 19388021
FZD3 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22944199 19388021
DVL1 ROCK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15121866 23331499
JUN MAPK10 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 18793328 10871633
RELA JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17310108 10646503
JUN AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12832543 11192249
JUN CASP8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18196534 17922191
JUN TNC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9154819
JUN IL2RA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14660657 7889400
JUN MAPK10 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 19527717 7148309
NGF RAPGEF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7806500 9560161
CASP8 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11002417
MYL12A CHUK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
CHUK IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12351658
RELA CDK4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18425349
RELA DNMT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23457487 24025864
RAPGEF1 SRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ACTN1 SRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6672010 16291744
SRC ACTN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6672010 16291744
SRC F2R â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16580177 9924018
ROCK1 PPP1CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19306866
PRRX1 TNC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11463719 12741393
ITGA1 ILK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 19397781 26148229
ITGB3 ILK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12372433
ILK SPARC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16115889
EGR1 RBL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22431919
EGR1 STMN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19786090
EGR1 IGF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12384981
IRS2 IGF1R â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8662806 5221055
PPP1CA AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8288823 20186153
PPP1CA AKT1 â—¼   COLOCALIZATION 2.0 0.8 intact 8288823 20186153
PPP1CA AKT1 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 intact 8288823 20186153
COMP ITGB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20033473 32196115
PPP2R1B CDK4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8208439 17540176
PPP2R1A CDK4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8208439 17540176
CDK4 RBL2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 11157749 9144196
IL3RA PRKCA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PAX6 FN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21540023
FN1 SDC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23290138 27235146
RAPGEF1 IRS2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11443118 11124936
PLCG2 IRS2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15644415 8034732
TGFA MAGI2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217468 15652357
PPP1CC CDC25C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14592972 16467385
NOTCH2 MAML3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17284587 11101851
NOTCH2 MAML1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17284587 11101851
RBPJ NOTCH2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9032325 19147558
RET NRTN â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15044950 11491658
ARTN NRTN â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15044950 11491658
RET ARTN â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15044950 11491658
SDC2 SDC4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18093920 0708909105
SDC3 SDC4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18093920 0708909105
SDC4 SDC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18093920 0708909105
SDC4 SDC3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18093920 0708909105
PAX6 RB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23622063 15558475
E2F3 RBL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10766737 18319725
SRF FOSB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22649236 10925151
SRF IL2RA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8455627 7636248
PRRX1 SRF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9334314
PAX6 TGFB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 27771509 19132093
RBPJ MAML3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17284587 11101851
RBPJ MAML3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21873209 12370315
MYB PAX6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9371644 7838532
PAX6 G6PC2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15180990 18753309
SDC2 SDC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18093920 0708909105
SDC3 SDC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18093920 0708909105
SDC1 SDC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18093920 0708909105
SDC2 SDC3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18093920 0708909105
SDC3 SDC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18093920 0708909105
IGF1R PIK3R1 â—¼   PHYSICAL_INTERACTION 806.0 0.8 STRING 36370105
ATP6V1B1 ATP6V1H â—¼   PHYSICAL_INTERACTION 807.0 0.8 STRING 36370105
FGFR1 PIK3R1 â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
CDK4 RBL1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 22094256 12006580
ITGA2 ITGB1 â—¼   PHYSICAL_INTERACTION 811.0 0.81 STRING 36370105
GYS1 PPP1CC â—¼   PHYSICAL_INTERACTION 811.0 0.81 STRING 36370105
GRB2 RET â—¼   PHYSICAL_INTERACTION 818.0 0.81 STRING 36370105
DVL1 APC â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 20224554 11425858
IL3RA GRB2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17474147 7523859
RECK IFNA4 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
TGFB1 LAMB1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 27684187 20936779
FGF1 SDC2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 26186194
GSK3B GYS1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21985244 6772446 11427888 24165324 16282323 10481074
FOSB CREB5 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 32296183 33961781
RB1 E2F3 â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 5219804 17380128
RBL2 RBL1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 15467457 17531812
IFNA4 IFNA8 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
ATP6V1B1 TCIRG1 â—¼   PHYSICAL_INTERACTION 823.0 0.82 STRING 36370105
ATP6V0B ATP6V1H â—¼   PHYSICAL_INTERACTION 823.0 0.82 STRING 36370105
PPP2R1A PPP2R3A â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
AKT1 GSK3B â—¼   DOWN_REGULATES ✅ - 0.82 0.82 Signor 15829723
AKT1 GSK3B â—¼   PHOSPHORYLATION ✅ - 0.82 0.82 Signor 23552696
FGF2 FGFR4 â—¼   PHYSICAL_INTERACTION ✅ + 0.82 0.82 Signor 1385111
PPP1CA RB1 â—¼   PHYSICAL_INTERACTION 828.0 0.82 STRING 36370105
TGFB1 LAMC1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
FGF1 SDC4 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
E2F3 RBL1 â—¼   PHYSICAL_INTERACTION 830.0 0.83 STRING 36370105
ITGB6 TGFB1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
IGF1R IGF2 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
ATP6V0D1 ATP6V1H â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
GRB2 IRS2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 7559579 22974441 9852124 21706016
DVL1 SMAD3 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 12650946
TGFB2 TGFB1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 27684187 11483955 33961781 11157754
FGF2 SDC4 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 16982797 33961781
AKT1 IRS1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 10497255 17640984
PKN2 AKT1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 10926925
AKT1 CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 0.84 0.84 Signor 18423396
GYS1 PPP1CA â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
ITGA4 ITGB1 â—¼   PHYSICAL_INTERACTION 844.0 0.84 STRING 36370105
ATP6V0D1 TCIRG1 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
ITGAV ITGB1 â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
NRTN RET â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
CDK2 RBL2 â—¼   PHOSPHORYLATION 0.85 0.85 Signor 11157749
SRC GRB2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 16189514 16713569 11964172 9016807 12624098
FGF2 SDC3 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 16982797 8344959
RBL2 CDK4 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 22094256 33961781
IGF1R IRS1 â—¼   PHOSPHORYLATION ✅ + 0.85 0.85 Signor 17827393
CHUK RELA â—¼   PHOSPHORYLATION ✅ + 0.85 0.85 Signor 10521409
ATP6AP1 ATP6V0D1 â—¼   PHYSICAL_INTERACTION 859.0 0.86 STRING 36370105
PIK3R1 GRB2 â—¼   PHYSICAL_INTERACTION ✅ 0.86 0.86 mint 5220480 7642581
FYN SDC3 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16189514 9553134 16713569
FGFR1 FGF4 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 11486033 10748122 14613973
FGFR1 FGF8 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 18199118 25241761 10574949 22244757
AKT1 NOS3 â—¼   PHOSPHORYLATION ✅ + 0.86 0.86 Signor 24379783
FYN PLCG2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 8395016 16189514 16713569 7682059 12181444 15144186
LAMC1 LAMB1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 17517882
AKT1 TCL1A â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
AKT1 CHUK â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
FN1 ITGB1 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
HRAS NRAS â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
AKT1 CDKN1B â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
CRKL PIK3R1 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
CHUK RELA â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
JAK2 FYN â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16713569 10551884
GSK3B SMAD3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 21310903 18172167
SMAD3 RBL1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16189514 12150994
IRS1 JAK2 â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
SRC RET â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16189514 33961781 32062451 10070972
ILK AKT1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16189514 12149249 9736715 12176337 11445557 18339839 11825911 11313365 14500673 11278835 11546794
FGF2 SDC1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 16982797 33961781 19802384
FGF2 SDC2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 16982797 33961781
IGF1R IRS1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 7559507 8776723 10082579 7541045 8530377 33991522 8895367 12220227 15629149 8662806
RBPJ MAML1 â—¼   PHYSICAL_INTERACTION ✅ 0.88 0.88 mint 8176976 21475249
AKT1 NOS3 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
PPP1CA PPP1CB â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
NOTCH2 RBPJ â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
FYN MAPT â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
PPP1CB PPP1CC â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
ITGA1 ITGB1 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
ANXA2 GRB2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16189514 31980649 12577067 7510700 9565634 19380743
RET GRB2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16189514 32062451 9393871 8183561 7665556 10995764 15677445
AKT1 TERT â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28628118 15843522 28205554 10224060 18775701
SRC FYN â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 31980649 19711372 9169421 33961781 16966330
IL3RA IL3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 9278420 7957082 8649415
FGFR4 FGF1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 1709094 25241761 10336501 10736564 33961781 7680645 11714710
PIK3R1 SRC â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
CDK2 RBL1 â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
CDK2 RBL2 â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
RBL2 CDK2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 9891079 17531812 25852190 9472014 33961781 26186194 23602568 10825149 23455922 9188854
RBL1 CDKN1B â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 11884610 7797074 9144196
JUN CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10700231 20566634 19959471
ITGB3 GRB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12005431 9566877 7997267
PDGFB GRB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 7935391 8388543 9739761
RAP1A GRB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12005431 9566877 7997267
ITGA2B GRB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12005431 9566877 7997267
JAK2 GRB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 7500025 17474147 8536716 8950973
IRS2 GRB2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 19109239 7890616 9535722
FN1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18624398 19738201
FYN GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7499280 9344857
MAPK3 RAP1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 27503831 16939974 9560161
MAPK3 MAP2K2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 10567369 19219045 8013650
MAPK3 PPP1CA â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 intact 211739200 12840032 8214413
FGF2 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9490736 29436393 12750158
MAPK3 PPP2R5C â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16456541
RET PIK3R1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11002419 10995764 10448070
EREG PIK3R1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18721752 10722704 8617750
PIK3R1 ARTN â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11002419 10995764 10448070
PIK3R1 NRTN â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11002419 10995764 10448070
PIK3AP1 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22187458 11163197
AKT1 PPP2R5C â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 Reactome 1325671 17200115 19576174
CASP8 PSEN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10069390
SGK1 SRF â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 18088355 15733869 22053691
PPP1CB NOS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19036824
ATF4 JUN â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 25241761 1827203 20936779 23661758
ATF4 EIF2AK2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23009153 21146245 17141186
TCL1A AKT1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 25416956 10983986 25910212 29997244 27229929 26871637 12009899 11707444
PDGFB CRKL â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10508235 9546424 9739761
JUN EZR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19164283
PRKCI EZR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18270268
ITGAV COMP â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16051604 20033473 15345499
ITGB1 LAMB1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11964076 16413178 16581764
ITGB1 LAMC1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11964076 16413178 16581764
ITGB1 COMP â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16051604 20033473 15345499
AKT1 ITGB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16256741 10896934
LAMB1 ITGB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10842354
COL4A1 ITGB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8223488
SRC ITGB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10592173 11723131 11259684
FYN GSK3B â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 17607942 15676027 15652488
FYN RAPGEF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17474147
AKT1 SMAD3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16362038 25241761
SMAD3 JUN â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 10903323 11306568 10220381 9732876 21829441
SMAD3 FN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16469949 12207925 15525600
SMAD3 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12374795 10022869
JAK2 IL3 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 2681215 1400495 1396555
JAK2 IL3RA â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 2681215 1400495 1396555
HRAS SDC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15752734 16997272 32196115
FN1 ITGA4 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 20644254 22067905 24202395
LAMB1 ITGA6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11964076 16413178 16581764
LAMC1 ITGA6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11964076 16413178 16581764
DVL1 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20006983 23331499 18347071
DVL1 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10428961 16914735 20837657
MAP2K2 RAP1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 27503831 16939974 9560161
FN1 RAP1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16040750 14754902 10446041
RAPGEF1 RAP1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22081014 8524240 9560161
CREB5 JUN â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 26496610 8440710 33961781 25609649 26186194 24981860
JUN STMN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17182846 15474303
JUN SPARC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11042689 7988564 12370830
JUN TIMP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9182717 23078099 18289921
CREB5 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8378084 8440710
RELA FOSB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20018891
RELA TNC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20723226 9154819
TLR4 TICAM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22664090 14519765 19656901
FN1 SRC â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16040750 14754902 10446041
SRC PPP2R1A â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 15637081 15004239 15564375
ITGA2 ILK â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 11112697 25100717 9456329
EGR1 MYB â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 7559553
EGR1 CD19 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9233624
COL4A1 ITGA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8223488
FGFR1 FGF2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 10748122 16829530 9174056 19627396 7520751 23597563 15096041 10950949 11030354 7730326 8609172 21693575 17086194 23597562 10574979 1697263 10490103 1722683 11786412 26267536 15548653 14505356 22539306 1709094 8868466 19696444 8692946 18199118 14613973
EIF2AK2 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 30071259 20685959 28779021
MYB IGF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10465027 19427836 23675407
AKT1 GSK3B â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19713527 8524413 23824745 16009706 29464284 20856200 19995607 16123141 20682768 27563096 14645548 15688030 22337773 11035810 17428466 18505846 15470047 14701753 16282323
PPP1CC AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 14633703
MTCP1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10983986 16189514 11707444
ITGB3 COMP â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16051604 20033473 15345499
PRKCA ITGB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16014375 10592173 17570479
PKM CDK4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CDK4 RBL1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 11884610 7797074 9144196
PRKCA GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19836308
FN1 ITGA3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9733622
FN1 ITGB8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7542940
LAMB1 ITGA3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11964076 16413178 16581764
LAMC1 ITGA3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11964076 16413178 16581764
RELN ITGA3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10939329
MAPK10 CDC25C â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20220133
DVL3 PIP5K1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18772438 23331499
GSK3B GNB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
RBPJ GSK3B â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
DNMT1 GSK3B â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
PPP1CA PPP1CC â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
PPP1CA NOS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19036824
PPP1CC NOS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19036824
PRKCI NOS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 24379783
LAMB1 ITGB4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11964076 16413178 16581764
LAMC1 ITGB4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11964076 16413178 16581764
COL4A1 ITGB8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7542940
PAX6 FGF8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17381541 15855760 11124114
MAPK10 STMN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20630875
CREB5 JUN â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
E2F2 RB1 â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
E2F3 RB1 â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
GRB2 PIK3R1 â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
APC GSK3B â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
ITGA6 ITGB1 â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
GRB2 IRS1 â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
FGF1 FGFR4 â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
PIK3R1 IRS1 â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 6731578 14632132
IRS2 PIK3R1 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
MAP2K2 MAPK3 â—¼   PHYSICAL_INTERACTION 924.0 0.92 STRING 36370105
CDKN1B CDK4 â—¼   PHYSICAL_INTERACTION ✅ 0.93 0.93 mint 5219242 17053782
CDK2 RB1 â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
FN1 ITGAV â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
AKT1 GSK3B â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
CDK4 RB1 â—¼   PHOSPHORYLATION ✅ - 0.93 0.93 Signor 9139732
PPP2R1B PPP2R5C â—¼   PHYSICAL_INTERACTION 939.0 0.94 STRING 36370105
FGF1 FGFR1 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
ATP6V1B1 ATP6V1G1 â—¼   PHYSICAL_INTERACTION 945.0 0.94 STRING 36370105
JAK2 IRS1 â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 11208867 12960006 9492017 15316008
DVL1 DVL3 â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 32296183 10330181
JUN FOSB â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 29020630 33961781 25609649
NID2 LAMC1 â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 16189514 9733643 33961781
CDK2 CDKN1B â—¼   PHOSPHORYLATION ✅ - 0.95 0.95 Signor 17409098
FGF2 FGFR1 â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
RBL1 CDK2 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 16189514 9891079 33422522 25852190 11884610 9472014 33961781 26186194 23602568 8230483 8491188 23455922
JUN MAPK10 â—¼   PHYSICAL_INTERACTION 962.0 0.96 STRING 36370105
ITGAV TGFB1 â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
FYN SRC â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
APC GSK3B â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 11166179 29045831 21118991 8638126 11251183 23602568 29568061
CDKN1B CDK2 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 34591612
IRS1 GRB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 7488107 8388384 7486683 8810325 22974441 21706016 8491186 7629070 12173038 8536716
LAMB1 LAMC1 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
PARD6B PRKCI â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
FN1 ITGB3 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
MAML1 RBPJ â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
DNMT1 RB1 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
IGF1R IRS1 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
CDK4 CDKN1B â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
ITGA2B ITGB3 â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
FGFR1 FGF1 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 16189514 25241761 10748122 8321198 23597563 1309595 11714710 9624181 11030354 7730326 11032250 28769084 1697263 22244757 1722683 22955284 10336501 8756477 18261743 18441324 1709094 8576175 33961781 8692946 1383494 18199118 10830168 14613973
PPP2R1A PPP2R1B â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
GNB2 GNG10 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CDK4 RB1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB4 GNG4 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB4 GNG3 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB2 GNG3 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB2 GNG4 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GSK3B MAPT â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
IRS1 PIK3R1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
PPP2R1A PPP2R5C â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
CDK2 CDKN1B â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
GNB2 GNG2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
GNB4 GNG2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
APC JUN â—¼   PHYSICAL_INTERACTION 33.0 1.0 ACSN 11274345 11955436 11967263 12051714 12711682 15001769 15327769 15834423 16039586 16510874 16547505 16940750 17143292 17439715 17936032 19216735 19506021 19619488 19623618 19751508 20006983 20705860 20964627 21285352 21681822 22270359 23343194 24023259 25730849 26587781 7542250 8545107 8666229
APC JUN â—¼   SHARES_COMPLEX 33.0 1.0 ACSN 11274345 11955436 11967263 12051714 12711682 15001769 15327769 15834423 16039586 16510874 16547505 16940750 17143292 17439715 17936032 19216735 19506021 19619488 19623618 19751508 20006983 20705860 20964627 21285352 21681822 22270359 23343194 24023259 25730849 26587781 7542250 8545107 8666229
CHUK APC â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11955436 11967263 12051714 12799363 23430059 7542250 8666229
GSK3B APC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 16944320 11166179 16799642 11967263 14663202 8524413 12554650 8638126 17910481 15327768 10581160 11487578 17318175 15465828 10228155 15020233 10421629 10698523 9832503
RELA BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18034190 18158998 20056115
AKT1 BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 26763134 14766748 15642728 17525161
GSK3B BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 29379583 27762303 15525785 20976235 26287183 17911107 16709574
RB1 CDK2 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 10323868 10375532 16582612 12730199
CDK2 SMAD3 â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 10197981 11283614 12193595 14536078 15147722 15241418 15279786 16156666 17055429 17303408 17660363 18590585 18636226 20027199 20713526 2191300 28536364 7575488
CDK2 RB1 â—¼   ENZYMATIC_REACTION ✅ 27.0 1.0 ACSN 12086603 14536078 14988723 15136767 15147722 15175241 15279786 15798197 16713580 16805667 17102137 17116885 17296725 17303408 17384638 17582221 17660363 18469862 18590585 18636226 18995830 19282663 19342888 19622404 19793801 20051983 7575488
AKT1 CDK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18354084 29665367
CDK2 DNMT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21565170
CDK2 PPP1CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 12202491 17145710 14715909 17274640 16550609 18088087 17570479 9122166 97225924 15212693 10880350
CDK2 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 34.0 1.0 Omnipath 10197981 15241418 19218245 25241761 15520018 20068231 17099224 16156666 16189514 19413330 14512875 12193595 15212693 19114991
CDK2 RBL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 20857408 17570479 11042701 9188854 11157749 12006580 15212693 10825149
CDK2 CDC25C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20530684 28396830
CDK2 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 77.0 1.0 Omnipath 26581405 9315635 17303408 18692063 23437375 19413330 20871633 26148348 28806746 15279786 16326706 8626527 21902831 14627988 7575488 9190208 21697511 9139732 20068231 17570479 16189514 12006580 11420722 18669648 15811853 18590585 27507850 17380128 23160093 19638577 1756735 20418918 19262748 17660363 11777937 10499802 19651622 20058876 15173007 22263797 10207050 8756624 10542199 19664994 24466208
CDK2 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 125.0 1.0 Omnipath 26416244 20519948 19631451 16326706 17409098 15557281 9658399 23029392 22733130 17570479 26496610 23576547 12700233 9388487 10585280 27282251 27175940 15619620 25241761 15735731 9218599 9192873 17254966 15996662 9724724 11940657 18285702 22492278 23409140 18615582 12093740 22721951 15647383 9380407 17418410 16189514 17053782 17698606 25852190 10679394 17602833 9660939 12188931 15122251 10831586 25818643 22028818 21424700 12529437 15011833 12042314 11250701 11223033 23455922 8978686 16780593 21439954 15302935 19648963 14504289 9736735 10198259 16782892 11565035 21423803 16492801 9311993 12417722 17671428 21187893 15355997 28601655 10809788 10393546 15212693 10323868 26450989 23602568 18850315 12482975 9399644 15890360 9632134 17254967 26186194 20810788 20197382 15475007 12800980 17997402 12972555 15980415 24336329 26701207 25605247 26987798
RB1 CDKN1B â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 Reactome 10207050 9447971 24876129 31543423 11416152 11032757 9190208 30711375 10499802
MAPK3 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 33574916 10781063 30976006 10375532 17409098 17209046 34407842 11425869 27140628 10931950 17254967 12700233 19584057 16160006 11726503 11889117 26528715 10831586 12907657 16880511 12140288 19473963 15735731 12529437 25132260 17254966 21715330
SGK1 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 42.0 1.0 Omnipath 26344141 15057270 26223520 12244303 15743786 23707388 19118035 20338997 11154281 18519679 26684356 33316141 12244302 15280662 27197201 18593906 25684140 18925875 24949832 17934340 11500365 18636226 20966355 15579463 16790529 21715331 26701207 19584721 20832730 12244301 18570873 21531565 22139837 23230143 18710949
PIM1 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 21062737 18593906
SRC CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 17145710 29899857 28882106 18627125 28522571 21045138 17254967 20519948
AKT1 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 69.0 1.0 Omnipath 22119715 11756412 16780593 11923280 16697215 16209941 12244303 20398329 18372248 14967450 18710949 15808505 26053093 20138985 14504289 20214616 12244302 17570479 18593906 23576547 23400686 12851486 15169778 24651496 19829074 25241761 10949026 16288292 11715018 18636226 19377290 9812896 12042314 17680028 10722653 20832730 18570873 12244301 17052453
CDKN1B CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 35.0 1.0 Omnipath 23602568 8978686 23707388 21439954 18850315 16326706 9658399 14597415 18615582 10198259 16782892 9632134 16189514 17053782 11360184 9311993 17092340 20837141 26186194 25241761 15695403 9464540 19470470 9106657 10908655 23543736 11940657 18285702
FGFR1 GRB2 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 17505008 18757403 21666749 11689702 11739186 18381441 19809159 21160078 14534538 15448205
IRS1 GRB2 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 8316835 8810325 9832424 8621421 8530377 9852124 9003010
FGFR4 GRB2 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 17505008 18757403 21666749 11689702 11739186 18381441 19809159 21160078 14534538 15448205
GRB2 FLT4 â—¼   PHYSICAL_INTERACTION 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
GRB2 CRKL â—¼   PHYSICAL_INTERACTION 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
GRB2 CRKL â—¼   SHARES_COMPLEX 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
GRB2 FLT4 â—¼   SHARES_COMPLEX 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
FYN GRB2 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 9822663 15886116 10849438 12670394
HRAS GRB2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
IRS1 GRB2 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 10086337 10826997 12175651 12444011 12767520 16931767 17604717 19030972 21540285 22465479 24036369 8621421
JUN GRB2 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 11274345 12738796 17439715 18039929 26587781 8545107
NRAS GRB2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
GRB2 FLT4 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
GRB2 PLCG2 â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10072481 10086337 10567412 10781611 10811803 10982827 11169415 11447289 11777939 12175651 12640133 14764585 15567848 15574420 16102570 16329184 16582911 16887996 17496910 17673906 19449109 19494291 19909365 23620508 25137453 26552706 7523143 7890616 8551221 8649391 8976179 9489702 9535722
GRB2 PIK3R1 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
GRB2 ITGA4 â—¼   ENZYMATIC_REACTION ✅ 26.0 1.0 ACSN 10086337 10426994 10567412 10811803 10982827 11447289 11777939 11777960 11907067 12175651 12640133 15536084 15567848 15574420 16339513 16582911 16713974 16887996 17070508 17100878 17496910 17673906 18490724 19449109 26552706 8551221
GRB2 ITGB1 â—¼   ENZYMATIC_REACTION ✅ 26.0 1.0 ACSN 10086337 10426994 10567412 10811803 10982827 11447289 11777939 11777960 11907067 12175651 12640133 15536084 15567848 15574420 16339513 16582911 16713974 16887996 17070508 17100878 17496910 17673906 18490724 19449109 26552706 8551221
GRB2 FYN â—¼   DOWN_REGULATES ✅ - 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
FLT4 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9927207 8662748 7675451 7970715
RET GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9393871 16189514 15677445
IRS1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 8265614 7862167 11788580 8388384 8491186 8536716 7488107 7486683 10358772 10592173 8196603 12173038 12679424 8114695 11259577 8810325
JAK2 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8536716 8950973 7500025 17474147 19273609
IRS2 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 7559579 11788580 10358772 11305324 9852124
SRC GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 12624098 11964172 9016807 16713569 26103942 20554525
GRB2 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17496910 16713569 17673906 11352655
JUN HMOX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8774698 24755082 8872603 20486760 20833713 18689604
AKT1 HMOX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15581622
NRAS MAPK3 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
HRAS MAPK3 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
MAPK3 MAP2K2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11802164 15239952 21779496 11802165 15260967
FGFR4 MAPK3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
FGFR1 MAPK3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
MAPK3 SMAD3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 10197981 16156666 27153775 29577978
MAP2K2 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 101.0 1.0 Omnipath 19901323 17081983 11704645 9694850 12750173 1411546 19690332 12932319 18799465 16497976 18083107 11134045 8626767 9006895 17389395 19219045 15342917 9447970 16887817 23331499 17569879 7867743 7559390 21071413 19534553 8226933 20068231 8223433 17272394 93330262 15851026 15811950 26987942 18988627 19494114 18669648 19541618 11242034 15466476 18691976 1381507 17906627 11986622 19933846 8376945 11971971 17192257 11136732 11948414 7898932 7687743 9731057 19651622 11730323 16464493 18983981 11251083 11118451 15580310 19369195 18707149 12920017 15951569 15466214 10746662 15212693
RET MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 551.0 1.0 Omnipath 15956760 25485910 17240116 20385359 12527803 17621270 23612968 18212246 21860413 18097051 18851832 10645003 25679764 21423210 15007380 19934253 19935718 22356909 9677429 15781651 10849428 17188005 20667468 14625304 34380633 17377139 21423211 20010870 26186445 20736304 12376318 33627405 16740736 21561860 15004239 17901130 15212956 15897464 15143154 18819921 17157789 26297582 12138104 11777927 22158866 23195225 34473994 20494825 14963038 16778204 17391526 27683117 22689060 12444552 31933886 15059947 26823016 15657432 19377875 17142325 15486045 21460222 23431142 11159838 27654866 19941816 14718389 34375550 18593598 17360704 23997214 24501773 16163708 10604992 15297577 17106060 24396487 25893857 20361349 16822962 12554776 18454177 29434871 34530870 16141331 12356731 19169277 20543098 17685427 21478906 18463290 16250012 20534535 21228323 7535768 26617336 15963258 10617652 17196532 19995915 10464310 15315965 12082540 21685939 25730857 18305109 25703330 16928771 15681433 11083859 16076871 20395206 23146907 26246800 21454539 12660819 21220474 15866871 15637081 19858202 34403210 18032526 16195541 21829454 16459330 17209045 12808105 11585739 16162500 25833830 18246127 11864968 24418169 15935618 19925796 20160123 17056593 14998784 18215133 10508618 18775330 18760948 12952943 21768338 17317777 8155326 22258404 15788397 26919095 28213521 21192818 33798093 15851026 26242183 12402043 21868357 17064352 20927383 16380505 15035987 21454675 18957207 19193766 21188622 19050043 16904111 19888469 26073130 20185553 15282551 16790523 23405013 11994288 17510392 32081857 18941537 20930115 19106095 11043579 21499301 20145126 24427291 10958690 15939799 19088846 19286657 18424438 15308678 18198175 27323814 24338688 24252946 19956644 21478903 12014987 23017243 17525129 12511559 17615152 16505244 20122898 12077249 17123942 26035354 11278407 15665049 20531297 17292825 14976148 16449644 16461767 23361053 19261611 11502744 25658205 12149254 30327409 17560175 24352879 26586479 26804906 25779944 34125833 19118012 11352917 16740725 11884401 16464862 16641227 27323830 18063582 22955283 24561529 10779765 10542198 16135812 23564461 17210721 24469048 24803537 21602434 17110601 21045017 11073973 10597231 23687376 34556812 17341659 18692468 17579083 12384403 21408150 25417160 11752053 23325789 17371847 11970985 22327338 26265441 16840783 17283152 26616862 23188829 17239630 21487005 11024037 17053147 24363437 25682201 20234004 12391272 23644655 25638159 20808799 17922836 20129247 24913355 18451171 25483104 26296889 21081844 17404396 11287604 18263590 26317416 15541367 16467309 12765939 16331263 16498402 20485667 11230338 16387841 19543320 7687743 20228268 15630487 16774943 16710359 10803464 16844778 16574647 15994317 17495961 21215800 17590453 26382850 19002495 12909616 20599567 12558965 10667594 24711455 17255109 16038803 12370087 21072043 20008839 18805968 10206983 11875080 20231899 21499296 21908610 16002410 12821943 24292678 17525735 17928416 21057531 25236495 17283137 21659545 24403530 16919488 23378338 22973961 18847491 16682955 20840866 16153436 23542175 24492000 12526087 26556867 12133965 12433918 20065107 14610044 11959800 15580310 21730285 11046056 9124279 14707024 26725216 16452220 22212957 25811962 15696170 11416124 20498373 17157787 21653826 16149052 20022946 34262144 16434970 10558990 18045996 10925301 16280323 25581518 15899879 21441955 20566643 15466476 15657177 11706017 15059847 8444886 18519681 23528009 33513601 20138986 12368275 24608435 17062641 20082306 20375017 17537990 24567333 33820494 10712263 21278199 19011679 20145145 27582276 25640183 21730054 16177091 17250586 15879307 16728403 18299328 24269888 17303383 9482941 17671177 17173941 24095720 15304500 12874275 33828192 11827968 33731431 10799542 15328343 18838481 19036157 17634226 17110082 17855349 31722981 26079947 25002506 14559232 23584478 18593910 17114467 16373398 16931794 17016429 14676826 28415597 12029087 24269383 8626767 20478260 12097262 14764579 12181310 15100319 12384432 15271996 17562849 19036927 19326083 20072652 25940440 11922392 17913704 19494114 25596730 18938240 27449290 12897059 21478911 21123455 26804170 10940302 16624816 26876209 12048182 17150968 21478863 17307705 18658095 24995980 16582879 17289590 33667549 17209041 17890097 21726627 27662093 16843264 19426503 11103941 11940578 17906618 26234813 19029090 15007386 15958730 12576312 17667937 17785202 34480897 20647329 18941890 16446383 25562429 10867021 26985018 16413470 23178720 25578563 34437586 21738699 21258408 20388777 24681954 20459645 12242309 15289328 21575862 16185843 19147767 34497368 19153083 12124352 17371994 17567959 15611080 17297454 23012246 14557270 28542650 15713673 21129803 19460345 10958798 21772273 21900206 19205871 17591920 19217381 12963813 19718025 24469056 16624867 21149447 15728578 33902596 11971971 16455819 19112174 10751321 1835084 11016927 18267069 20410276 21980390 17409387 23831578 21477078 15558056
PRKCA MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11704645 12598525 19074803 8903320 9160888
MAPK3 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 15001544 16131083 8626671 14769130 9335553 15613682 12510059 15212693 9395471 14579029
MAPK3 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 27342992 23405013 18411303
MAPK3 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 23331499 10197981 15241418 24080014 18775330 8226933 16156666 9604935 12193595 8388392
MAPK3 CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 24342355 17290218 26036637 29233910 24484936 20937773
MAPK3 MYB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 8798443 8960373
MAPK3 STMN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 72.0 1.0 Omnipath 17081983 18767875 9731215 20230923 17693683 11135364 19413330 8314790 19664995 19415658 16083285 20068231 18452278 9712920 30628717 94064639 1737801 18491316 18669648 8144611 8245003 26505358 17287340 16094384 19033656 19651622 20058876 8376365 8325880 17924679 19162178 19664994 18707149 25692552 8125092 16964243 18212344
MAPK3 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 16039586 28646232
SGK1 MAPT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 15650334 17570479 16982696
FYN MAPT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 20110615 21794954 20812151 21741124 22482453 24646911 25963821 11826099 22783199 29036830 25156556 16115884 27693185 28526038 28251926 31201283 28033507 24860422 15356202 14999081 21692989 20609109 16014719 22121920
GSK3B MAPT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 141.0 1.0 Omnipath 19616957 22278060 25641096 9832145 19562805 12387894 24268883 9546672 31640277 21865886 19413330 28386764 28379300 1330687 28734998 19415658 15302935 17047304 7706316 27349344 29408874 9716264 9353289 21671254 24165324 12714590 20068231 12387897 17570479 16452634 25815351 21215781 16568235 16519507 8999860 17045592 9565682 27857758 11181841 14690523 22690349 27073700 21443865 10601262 7566346 10737616 15522877 12435421 17287340 9771888 29725295 15073173 17078951 19651622 1181841 15542598 9735171 12226093 11104762 21985244 20049527 28835279 27965573 20679343 20308788 9199504 18510355 10090741 11311121 2387894
NRAS PIK3R1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 31135801 24897931 8665852 17998941 11136978 21779505 8052307 12121613 1716764 26085527 21779497 12094235
FGFR4 PIK3R1 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 17505008 18757403 21666749 11689702 11739186 18381441 19809159 21160078 14534538 15448205
FLT4 PIK3R1 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
CRKL PIK3R1 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
CD19 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 7684160 10201980 7528218 25673924
HRAS PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9069260 25241761 10212255 11313862 9150145 16713569 15021914
IRS2 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 21241768 23439647 11024460 19561084 12107746 9334184 15715521 11438664 15514089 26496610 9233603 23617393 8910607 9852124 19109239
IGF1R PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 8603569 17496910 25241761 8697095 7642582 17570479 18595745 7589433
JAK2 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8702385 12706299 16135792 17474147
IRS1 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 60.0 1.0 Omnipath 12444011 11788580 14632132 14511371 19030972 16931767 7486683 21798082 11403293 12173038 8382612 12220227 12767520 10826997 16230374 7680095 23439647 19561084 16150444 12107746 10358772 11748924 12175651 7499365 7935461 15316008 9564850 16354680 16043515 12730242 11416002 7680644 23643389 21540285 8628286 15514089 11438664 8175658 9233603 1381348 25814554
FYN PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 8294442 8394019 7515100 17570479 16713569 7520528 1652056
CRKL PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9092574 16135792 11418612 23397142 9461587 16982329
FGFR1 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17496910 18412956 25241761 15117958
PIK3R1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10527852 16799564 19442713
PIK3R1 PLCG2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17474147 25241761
PPP2R5C AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 18039929 19216069 11897496 10026142 10995457 18042541 20452955 18559511 18588945 16680151 16406523
PSEN1 NOTCH2 â—¼   CLEAVAGE ✅ 5.0 1.0 Reactome 24842903 10206645 12209127 9620803 11518718
GSK3B PSEN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 11104755 17389597 17360711 16814287 10997338
PRKCA PSEN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 14576165
PSEN1 NOTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11518718
RELA SIRT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20617556 15152190 24064732
SIRT1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 19408108 25217963 15152190 21081649
SMAD3 TERT â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 16474430 17934056 16785237 19193721 17881189 16205635 20842112
AKT1 TERT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 25999477 22366458 10224060 17570479 22902867 15843522 18775701
SRC TERT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 12808100 20211239 24413564 26908447 18829466
PPP1CB ROCK1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 9354661 8662509 11331307 11942626
PPP1CB AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20186153 14633703
TCL1A AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 10983986 25910212 26871637 10716693 25416956 29997244 12009899 19770358 31515488 16189514 11707444 15169787
CRKL RAPGEF1 â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 10426994 11062502 11353765 11385609 11447289 11526404 11579131 11687500 11907067 12670391 15169881 15308668 15536084 16000375 16076871 16713974 17397400 18250477 18287025 18835194 19109239 19454690 19909365 20189481 20805416 21149606 21826665 22464172 23087689 23523669 24751819 24795729 25960930 7682895 9314552
CRKL FLT4 â—¼   PHYSICAL_INTERACTION 56.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11335727 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15308668 15501236 15520864 15567848 15573129 15574420 16000375 16002046 16076871 16530705 16572188 16582911 16887996 17086423 17496910 17673906 17883421 18835194 19414323 19449109 19454690 21372296 22064427 22461508 22464172 23390297 24217602 24346288 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
CRKL FLT4 â—¼   SHARES_COMPLEX 56.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11335727 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15308668 15501236 15520864 15567848 15573129 15574420 16000375 16002046 16076871 16530705 16572188 16582911 16887996 17086423 17496910 17673906 17883421 18835194 19414323 19449109 19454690 21372296 22064427 22461508 22464172 23390297 24217602 24346288 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
CRKL RAPGEF1 â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 10426994 11062502 11353765 11385609 11447289 11526404 11579131 11687500 11907067 12670391 15169881 15308668 15536084 16000375 16076871 16713974 17397400 18250477 18287025 18835194 19109239 19454690 19909365 20189481 20805416 21149606 21826665 22464172 23087689 23523669 24751819 24795729 25960930 7682895 9314552
FYN CRKL â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 10591186 10648627 11062502 12218089 12731048 15536084 19290918 19909365 20814939 21378271 22683124 22863785 24440149 27192565 9738502
CRKL FLT4 â—¼   ENZYMATIC_REACTION ✅ 56.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11335727 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15308668 15501236 15520864 15567848 15573129 15574420 16000375 16002046 16076871 16530705 16572188 16582911 16887996 17086423 17496910 17673906 17883421 18835194 19414323 19449109 19454690 21372296 22064427 22461508 22464172 23390297 24217602 24346288 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
CRKL RAP1A â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 11353765 15169881 15308668 16000375 16076871 18835194 19454690 20189481 22464172
CRKL RAPGEF1 â—¼   ENZYMATIC_REACTION ✅ 35.0 1.0 ACSN 10426994 11062502 11353765 11385609 11447289 11526404 11579131 11687500 11907067 12670391 15169881 15308668 15536084 16000375 16076871 16713974 17397400 18250477 18287025 18835194 19109239 19454690 19909365 20189481 20805416 21149606 21826665 22464172 23087689 23523669 24751819 24795729 25960930 7682895 9314552
CRKL RAPGEF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 8943292 10753869 8978305 16443220 11466412 8621483 9129019 10907644 18835194 10592173 9374471 10926930 9311917 10339478 11167825 12671687 9344843 9820532
ITGAV ITGB5 â—¼   PHYSICAL_INTERACTION 9.0 1.0 ACSN 10837075 11146654 14697347 15031725 18353785 22035837 22470492 9295024 9763615
ITGAV ITGB5 â—¼   SHARES_COMPLEX 9.0 1.0 ACSN 10837075 11146654 14697347 15031725 18353785 22035837 22470492 9295024 9763615
SMAD3 ITGB5 â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 8515656 9389648
ITGB5 ITGA2 â—¼   DOWN_REGULATES ✅ - 5.0 1.0 ACSN 22470492 24309651 26519775 9295024 9763615
ITGB5 ITGA1 â—¼   DOWN_REGULATES ✅ - 5.0 1.0 ACSN 22470492 24309651 26519775 9295024 9763615
FN1 ITGB5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 1694173 1532572 17015452 18480047
PRKCA EZR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 14504278 15531580 10970850 11387207 21899702 15843435 9516463 15647376
SRC EZR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 16438931 22397367 14504278 25231728 21818323 24339867 15623525 18701134 22262457 24385580 18078820 28306714 15647376
ROCK1 EZR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 8522586 9856983 14504278 15531580 9287351 10970850 12778124 12045227 11387207 19255442 15843435 12802084 7579708 19386264 10047517 8527459
FGF21 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22442730 16597617 25772309
FGF21 FGFR4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 22442730 16597617
ITGAV ITGB3 â—¼   PHYSICAL_INTERACTION 23.0 1.0 ACSN 10022831 10545505 10837075 11146654 11335727 11532940 11553709 12000961 14697347 15031725 16919435 18353785 19161977 19339212 19449109 22035837 7512751 7529872 7657702 8636223 8755653 9295024 9763615
ITGAV ITGB3 â—¼   SHARES_COMPLEX 23.0 1.0 ACSN 10022831 10545505 10837075 11146654 11335727 11532940 11553709 12000961 14697347 15031725 16919435 18353785 19161977 19339212 19449109 22035837 7512751 7529872 7657702 8636223 8755653 9295024 9763615
FN1 ITGAV â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 1694173 18480047 1532572 19738201 23154389 17015452
COL4A1 ITGAV â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 14610079
PDGFB SRC â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 7685273 9488729 10508235 9739761
EGR1 PDGFB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11222751 8596917 21368226 9488709 16092976
ITGB1 ITGA4 â—¼   PHYSICAL_INTERACTION 9.0 1.0 ACSN 12626562 19161977 19454690 19487819 22470492 9003039 9456329 9763606 9973479
ITGB1 FN1 â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 12731048 18037882 19161977 19454690 19487819 20644254 20814939 22067905 22470492 24202395 9003039 9456329 9763606 9973479
ITGB1 ITGA4 â—¼   PROTEIN_INTERACTION 9.0 1.0 ACSN 12626562 19161977 19454690 19487819 22470492 9003039 9456329 9763606 9973479
ITGB1 FN1 â—¼   SHARES_COMPLEX 14.0 1.0 ACSN 12731048 18037882 19161977 19454690 19487819 20644254 20814939 22067905 22470492 24202395 9003039 9456329 9763606 9973479
ITGB1 FN1 â—¼   ENZYMATIC_REACTION ✅ 14.0 1.0 ACSN 12731048 18037882 19161977 19454690 19487819 20644254 20814939 22067905 22470492 24202395 9003039 9456329 9763606 9973479
ITGB1 FYN â—¼   ENZYMATIC_REACTION ✅ 14.0 1.0 ACSN 12731048 18037882 19161977 19454690 19487819 20644254 20814939 22067905 22470492 24202395 9003039 9456329 9763606 9973479
PRKCA ITGB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12138200 12435334 20926684 11700305 10592173
RELN ITGB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 10725376 10939329
TNC ITGB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 14715956
FN1 ITGB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 9842903 22451694 17015452 18480047 19738201 7688313 1694173 6325925 25237190 26456826 10772816 7626807 21985969 6284125 1532572 11010812 8120056
ITGB1 ILK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 18339839 9736715 8538749 16189514 11402068
FN1 FYN â—¼   ENZYMATIC_REACTION ✅ 14.0 1.0 ACSN 12731048 18037882 19161977 19454690 19487819 20644254 20814939 22067905 22470492 24202395 9003039 9456329 9763606 9973479
ITGA4 FYN â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 12626562 19161977 19454690 19487819 22470492 9003039 9456329 9763606 9973479
FYN RELN â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 17350651 23052211 23506116 16529723
FYN PLCG2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 19901323 8395016 12181444 11606584 14656219 7682059 15144186 11507089 16497976 16713569
TGFB1 SMAD3 â—¼   PHYSICAL_INTERACTION 30.0 1.0 ACSN 10678166 11013220 11133108 11278410 11792802 12154066 12717440 12724770 14557817 15265520 15548370 16474430 17934056 19010789 19050695 19109155 19920116 20060931 20519943 20644162 21278795 21614932 21900405 22703233 22710166 24132110 24336330 7594497 9311995 9865696
TGFB1 SMAD3 â—¼   SHARES_COMPLEX 30.0 1.0 ACSN 10678166 11013220 11133108 11278410 11792802 12154066 12717440 12724770 14557817 15265520 15548370 16474430 17934056 19010789 19050695 19109155 19920116 20060931 20519943 20644162 21278795 21614932 21900405 22703233 22710166 24132110 24336330 7594497 9311995 9865696
TGFB1 SMAD3 â—¼   ENZYMATIC_REACTION ✅ 30.0 1.0 ACSN 10678166 11013220 11133108 11278410 11792802 12154066 12717440 12724770 14557817 15265520 15548370 16474430 17934056 19010789 19050695 19109155 19920116 20060931 20519943 20644162 21278795 21614932 21900405 22703233 22710166 24132110 24336330 7594497 9311995 9865696
CDK4 SMAD3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 10197981 12193595 15241418 16156666
SMAD3 FGF2 â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 8515656 9389648
SMAD3 TNC â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 8515656 9389648
SMAD3 ITGA11 â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 8515656 9389648
SMAD3 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 26553048 27974707 10708950 19214138
DVL1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 15888125 12650946 15955531
AKT1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 25241761 15104092 16362038 21071413 18988627 26297431 15048128
GSK3B SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23331499 18172167 21071413 21310903 23077590 28756206 19114991 19002158
CDK4 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 34.0 1.0 Omnipath 34003249 10197981 15241418 25241761 19920136 15520018 20068231 17099224 16156666 16189514 19413330 14512875 12193595 33051597 19114991
TGFB1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21557273 24899689 24075003 24485922 28756206 32196115
SMAD3 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 23331499 9732876 10220381 11306568 21829441 10903323
SMAD3 RBL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12150994 16189514
JAK2 IL6R â—¼   PHYSICAL_INTERACTION 36.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 22595692 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
JAK2 IL6R â—¼   SHARES_COMPLEX 36.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 22595692 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
SRC JAK2 â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 11476890 12094222 16919435 17496910 17517963 25572304 26552706 27216177
JAK2 IL6R â—¼   ENZYMATIC_REACTION ✅ 36.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 22595692 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
JAK2 TIMP3 â—¼   ENZYMATIC_REACTION ✅ 31.0 1.0 ACSN 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20856220 21115385 21840487 23124025 23390297 24030977 24091328 27216177 2965306 7512720 7521688 7543512 9834059
JAK2 IRS2 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23390297 24030977 24091328 27216177 2965306 7512720 7521688 9834059
IRS1 JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 9492017 7782332 11208867 21071413 12960006 15316008
IL3RA JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 15988755 17312100 15795318
PRKCA EIF4E â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 1911648 8662663 2355012 12897141 9155017 17570479 11723111 95301551 11463832 9878069
TGFB1 ITGA3 â—¼   PHYSICAL_INTERACTION 48.0 1.0 ACSN 10671552 11133108 11348595 11955436 11967263 12051714 12426320 14557817 15001769 15279786 15548370 16039586 16099633 16371504 16474430 17143292 17303408 17660363 17928543 17934056 17936032 18037882 18590585 19010789 19029934 19109155 19171760 19619488 19734908 19920116 20519943 20644162 20705860 21278795 21666923 21900405 22007144 22174153 22203675 22674073 22703233 23343194 24023259 25730849 7542250 7575488 7594497 8666229
TGFB1 ITGA3 â—¼   SHARES_COMPLEX 48.0 1.0 ACSN 10671552 11133108 11348595 11955436 11967263 12051714 12426320 14557817 15001769 15279786 15548370 16039586 16099633 16371504 16474430 17143292 17303408 17660363 17928543 17934056 17936032 18037882 18590585 19010789 19029934 19109155 19171760 19619488 19734908 19920116 20519943 20644162 20705860 21278795 21666923 21900405 22007144 22174153 22203675 22674073 22703233 23343194 24023259 25730849 7542250 7575488 7594497 8666229
TGFB1 SRC â—¼   ENZYMATIC_REACTION ✅ 56.0 1.0 ACSN 10671552 11133108 11348595 11476890 11955436 11967263 12051714 12426320 14557817 15001769 15279786 15548370 16039586 16099633 16371504 16474430 16919435 17143292 17303408 17496910 17517963 17660363 17928543 17934056 17936032 18037882 18590585 19010789 19029934 19109155 19171760 19619488 19734908 19920116 20519943 20644162 20705860 21278795 21666923 21900405 22007144 22174153 22203675 22370635 22674073 22703233 23343194 24023259 25572304 25730849 26552706 27216177 7542250 7575488 7594497 8666229
RELA TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 19385047 23195252 28148567 14600158 16365456 21255844 15051419
EGR1 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17916653 20417179 8794351 8058069 8051207 26279418 10783396 16138117 8876223 20690147 16702209 11707452
JUN TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 8058069 16327802 16730810 23437118 8183578 16365456 22429882 23936544 15546613 10843986 16978906 23762330 7521696 8631909 12794825
HRAS MAP2K2 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
HRAS FGFR1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
HRAS FGFR4 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
SRC HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 12695509 9626657 9020108 25157176 33413561
FN1 ITGA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 9117345 9842903 19738201 11010812
LAMB1 ITGA6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 7721947 11733063 10842354
LAMC1 ITGA6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 7721947 10671376 11733063 32196115
FN1 ITGB7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 1372909
DVL1 FZD1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL1 GSK3B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
GNB2 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19561403
SDC4 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23151663 18403410 16604063
ITGA2B RAP1A â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 14754902 8755247 11940607 17218263 18434644 10964917 10446041
SRC RAP1A â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 14754902 8755247 11940607 17218263 18434644 10964917 10446041
ITGB3 RAP1A â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 14754902 8755247 11940607 17218263 18434644 10964917 10446041
RAPGEF1 RAP1A â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 11353765 15169881 15308668 16000375 16076871 18835194 19454690 20189481 22464172
JUN IRS2 â—¼   ENZYMATIC_REACTION ✅ 37.0 1.0 ACSN 11274345 11955436 11967263 12051714 12417340 15001769 15279786 15337521 16007092 16039586 16510874 17143292 17303408 17439715 17565603 17660363 17936032 18590585 19619488 19623618 19879327 20006983 20144767 20530697 20705860 20920541 21285352 22020335 23296977 23343194 24023259 25730849 26587781 7542250 7575488 8545107 8666229
JUN NOS3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11382920 17933457 20371606 16453281 18556800 17919072
JUN FN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 24342046 21479385 11052809 9756884 23744703 10325245 11896591 10421838
JUN MYB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 1527086 8670250 12475180
JUN FGF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9456251 10913304 10559225 11281649 11551904 23485603 23331079
JUN NGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11905996 11733514 8717334 2111020
JUN SRC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 7499226 16798740 23533633 14736735 18216279
RB1 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10026157 9545246
GSK3B JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 23331499 1846781 25979842 25241761 20537194 21278055 21397588 17482134 1516134 8384355 17570479 16023596 17215518 30086763 92065884 24632621
RELA JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18174238 9468519 16713569 10488148
MAPK10 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 17143273 20506250 16824735 8654373 20028971 16007099 21988832 12167088 16393692 1922387 16076903 22327296 19527717 21757544 19436832 17670986 14523011 11274345 20395206 11562357
NGF IRS1 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 10086337 10826997 12175651 12444011 12767520 15099563 16931767 17604717 17764704 19030972 21540285 22421439 22465479 24036369 25071162 28645028 8621421
NGF IRS1 â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 10086337 10826997 12175651 12444011 12767520 15099563 16931767 17604717 17764704 19030972 21540285 22421439 22465479 24036369 25071162 28645028 8621421
TLR4 CASP8 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 21737330 12752666 15814722 16115877 14739303 21737329
SRC CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 27432652 16619028 19470771 27109099 27195913 19383910 30501030 24100030 22074016
TLR4 CHUK â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15064760 15814722 16115877 16603398 16547522
CHUK TICAM1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15064760 15814722 16115877 16603398 16547522
CHUK RELA â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 9315679 9914500 9721103 10593898 9135156
EIF2AK2 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10723127 10648614
AKT1 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 15710601 12048203 25241761 19442713 11278366 10485711 15800029 19609947 17570479 17660512 18515365 19088076 10485710
SRC CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 17145710 12707358
CHUK IRS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 16510874 23343194 21285352 22020335 23296977 11274345 16039586 17439715 20920541 20530697 15337521 8545107 19619488 19623618 17565603 17143292 20006983
CHUK RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 49.0 1.0 Omnipath 17145710 15611276 22110409 19609947 10521409 20863851 20051109 20363318 12767944 26999213 12842894 21903422 19110719 15858576 16382138 22155370 23894194 16046471 15128824 21569639 16846590 8246997 15485852 25341660 15494311 11983155 15980040 15489227 15849198 14636585 23343355
RELA AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20186924 18031796 20649564
RELA EGR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19276347 20427719 15616591 21983014
RELA FN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10649441 18064631 10867646 22223884 12372417
RELA IL2RA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23144749 9135552 11781710 7636248 8430069
RELA IFNA13 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 7957928 15331713 9446577 8035474
RELA NOS3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18397880 14570928 17081374
GSK3B RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 18201972 15465828 15280197 22761446 20537194 21194439 19345186 21660967 19997086 16407239 25629551 17183360
PIM1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22216091 19911008
RELA EGR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19915002 19837667 10671503
TLR4 TICAM1 â—¼   PHYSICAL_INTERACTION 11.0 1.0 ACSN 11672593 11964313 12032143 12811837 15644117 16306937 16917499 17114424 20154735 20547845 23508573
TLR4 TICAM1 â—¼   PROTEIN_INTERACTION 11.0 1.0 ACSN 11672593 11964313 12032143 12811837 15644117 16306937 16917499 17114424 20154735 20547845 23508573
IL3 IL3RA â—¼   PHYSICAL_INTERACTION 13.0 1.0 ACSN 11698286 12393492 15034038 15549123 15573129 17200410 18633355 22323450 23026134 23046136 23125331 23762788 24778133
IL3 IL3RA â—¼   SHARES_COMPLEX 13.0 1.0 ACSN 11698286 12393492 15034038 15549123 15573129 17200410 18633355 22323450 23026134 23046136 23125331 23762788 24778133
EGR1 IL3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8035792 19426596 18928619
IL3 IL3RA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 23331499 11700046 8649415 9278420 7957082 1465408
DVL3 FZD1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
GSK3B FZD1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
SRC FLT4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 16076871 12881528 20431062 18083107
ITGA3 SRC â—¼   ENZYMATIC_REACTION ✅ 56.0 1.0 ACSN 10671552 11133108 11348595 11476890 11955436 11967263 12051714 12426320 14557817 15001769 15279786 15548370 16039586 16099633 16371504 16474430 16919435 17143292 17303408 17496910 17517963 17660363 17928543 17934056 17936032 18037882 18590585 19010789 19029934 19109155 19171760 19619488 19734908 19920116 20519943 20644162 20705860 21278795 21666923 21900405 22007144 22174153 22203675 22370635 22674073 22703233 23343194 24023259 25572304 25730849 26552706 27216177 7542250 7575488 7594497 8666229
SRC ITGA9 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11476890 16099633 16919435 17496910 17517963 19734908 22203675 22370635 25572304 26552706 27216177
ACTN1 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17145710 16291744
PRKCA SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 24.0 1.0 Omnipath 17496910 11940581 21386996 10527887 2996780 11447289 19615955 16488589 6321473 8321321 12845332 11313945 2136766 17570479 12040186 19568798 15567848 14585353
PRKCI SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 17496910 11940581 21386996 11447289 19615955 16488589 6321473 8321321 12845332 11313945 12040186 19568798 11713277 15567848 14585353
SRC PLCG2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 30819914 12181444 11606584 14656219 7682059 15144186 11507089
SRC RAPGEF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 14551197 10318861 15320955 17474147 15212693 12734187
SRC ITGB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 10330414 17473008 8631894 18156175 25694433 18840695 18364349 18398066 10592173 16935858 21956114 17353363 18088087 12359711 15212693 14996908 15695822 15699036 11723131 20702409
SRC ANXA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 30081903 15302870 24239898 23594883 18083107 2415974 26716413 17389395 27821486 11106497 88296872 16189514 25574848 25303710 2456953 24727000 17287340 2143014 15212693
SRC RET â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11713247 17570479 16189514 10070972
SRC CAV2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 27.0 1.0 Omnipath 23826261 15212693 15504032 20455999 17081983 12091389 20068231 22819829 18081315 18669648
SRC IGF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 17389395 15212693 18691976 7559478 7493944 7537849 20068231 23472139 8550552 17016520 8940173 9480911
SRC AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 11445557 25241761 23242524 18283331 12600984
ROCK1 MYL12A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 8702756 11283607 26169356 12185584
TNC ITGA7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 14715956
TNC FN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 7499434 20708078 21349332
ITGA11 IGF2 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 17420280 17600088 19913614 20129924 25076207 26148229
PRKCA ILK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22521536 17570479 17420447
ILK AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 35.0 1.0 Omnipath 11546794 14500673 12176337 11445557 15899889 23840605 9736715 12149249 10592173 11313365 16189514 19460343 11278835 15212693 18772455 10226025 11825911
ILK GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 15207235 14990992 16799642 20827300 27683053 9736715 12960424 26547035 17490631 12629168 17182785 21035499 16189514 17107957 16936772 17485554
SRF EGR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17967787 12760745 18446785 16497989 16456537 11739517 10329706 15449318
EGR1 IGF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 14517213 9610618 11336542 8634146 10606246 8276819
EGR1 FGF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8702507 20053757 16818645 15247255 9178905
EGR1 FN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9933644 10783396 16138117 15608673
LAMA1 ITGA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9688542
FN1 ITGA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 7688313
FN1 ITGB6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 1694173 18480047 1532572 17015452
FGF1 FGFR1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 14517404 16272825 16682805 26183471 9242465
FGF1 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 49.0 1.0 Omnipath 16597617 8756477 1383494 8576175 9624181 1722683 11714710 23331499 21071413 14613973 10830168 16189514 23597563 25241761 22244757 7730326 25772309 1309595 18441324 18940940 11032250 10336501 11030354 8663044
FGF1 FGFR4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 11714710 7680645 25241761 16597617 25772309 10336501 1385111 10736564 8663044
FGF4 FGFR4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 11486033 114860338663044 16597617 1385111 8663044 25772309
FGF2 FGFR1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11874475 18232728 18633355 18776941 19508171 19631971 21098712 22652804 23123598 25374926 9242465
FGF2 SDC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 9556568 20382221 9012653 8621465 16982797 8609172
FGF2 FGFR4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 7680645 8530375 16597617 1385111 86630448530375 8663044 25772309
FGF2 SDC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 20382221 8621465 16982797 1101561416982790 8609172 11015614
FGF2 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 17145710 15096041 8868466 10490103 16597617 11030354 23597562 1722683 14613973 17086194 14505356 9174056 7730326 25772309 11786412 16829530 10950949 23597563 10574979 26267536
NRAS FGFR1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
DNMT1 FGFR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17172825 18704159 21779870 21150308
FGF5 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 16597617 83868288386828 8386828 25772309
FGF17 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10751172 16597617 25772309
IGF1R IRS1 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 10086337 10826997 11274345 12175651 12444011 12556535 12655147 12767520 16931767 17145802 17673906 19030972 21540285 24103846 24782617
AKT1 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17570479 17640984 10497255
PRKCA IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 22869320 15364919 16574739 17570479 15516986 15069075
IGF1R IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 44.0 1.0 Omnipath 7541045 12444011 19030972 10082579 16931767 21798082 12220227 11259577 12767520 10826997 23331499 17827393 7504175 21071413 7559507 11572799 27856640 12175651 17570479 15829723 18988627 15629149 11557037 20670944 8530377 21540285 8776723 25886138 8662806
IGF2 IGF1R â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 1310594 3019338 2839228 1845984 2969892 3011795 3013881 22140443 19139090 16981855
IGF2 IGF1R â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 11237532 15003992 17145802 17600088 24668028
IGF2 IGF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 9972281 23331499 22810696 20980691 14604834 11867533
IGF1R IRS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 8662806 9852124 10471495
RET AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12600984 15994200
PPP1CA AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20186153 14633703
AKT1 ITGB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 18578522 10896934
AKT1 NOS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 70.0 1.0 Omnipath 12759249 20166139 11756412 10376603 11923280 12446767 16697215 11044445 20398329 18372248 11696579 16126727 16839566 15808505 20138985 20299462 10908731 20363286 11988487 11425855 20214616 23103584 11729179 16043647 17570479 12171920 25460366 27322328 11978735 15169778 11029403 25241761 19654415 10949026 18048761 11715018 12791703 24379783 18636226 9812896 23397142 17680028 10376602 12431978 10722653 20832730 18570873 25009123 17052453
AKT1 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 99.0 1.0 Omnipath 17428466 15207235 17145710 12052830 10729337 8250835 11756412 11923280 16914735 17623045 16697215 8524413 12054501 20398329 18372248 21506126 20028971 12040186 15808505 16543730 20138985 23331499 21303971 16009706 10385618 20214616 23180781 9373175 16039586 15829723 18988627 16282323 11577096 11035810 18669648 18216173 15169778 12851486 16123141 11882383 23109003 9065430 18691976 22094462 10949026 22710759 11715018 12459251 18636226 17192257 11254732 11278246 20858269 9812896 9582355 15023346 17680028 19369195 7945242 12900420 23552696 18387957 10722653 20832730 18570873 12147701 18505846 17052453 17693255 18218901
AKT1 DNMT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 26553800 24492612 27521372 26216216 25949795 21151116 21565170
FN1 ITGB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 11423542 1694173 18480047 1532572 8663002 17015452
RB1 CDK4 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 Reactome 10207050 9447971 24876129 31543423 11416152 11032757 9190208 30711375 10499802
GSK3B CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 11152665 20537194 10385618 11124803 12969793 19757160 16732330 10486203 16039586 14536078 18167338 12459251 12615961
CDK4 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 107.0 1.0 Omnipath 26203195 10498883 23336272 9315635 17303408 17363486 25803170 10359571 15081408 16236519 28249908 16936279 17478427 19690332 11520855 31615938 15279786 16326706 18981099 9190208 8626527 14627988 7575488 24417566 9003781 16360038 10385618 9736735 9139732 7736585 20068231 34158578 16189514 19075565 18669648 11773438 11641415 21880723 18590585 27708221 10962560 20068082 15489884 9425340 19225156 19551155 17045206 10210318 19262748 18786381 17660363 17621266 19651622 12657252 11746527 11254678 15809340 22263797 10202152 10778858 27811360 23981302 19664994 14676836 9380698 18583321 23429262 27430527
CDK4 RBL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 38.0 1.0 Omnipath 10498883 17303408 16236519 11884610 8643455 19664995 15279786 7575488 10385618 9736735 19075565 12006580 18590585 20068082 17495531 18786381 17660363 19664994 10069453
CDK4 RBL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 10498883 10385618 9736735 11157749 12006580
PRKCA MARCKS â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1527003 7989336 9808756 11588141 8132675 17081983
PRKCA NOS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 33539947 25814956 12384459 27191895 18622039 27106139 12574113 12869534 21797845 11729179 21757745 25020117 28833096 12644458 24612481 24379783 16527893 16527820 12952971
PRKCA EWSR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 9341188 17570479 934118 11313922
PRKCA SDC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 9556568 11916978 14670076 12571249 12377772
PRKCA SRF â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 12809504 19778940 21777672 16537394
PRKCA ITGB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 17615294 12919677 15121854 19005215 10592173 10477766 22824799 20870721
PRKCA MARCKS â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 79.0 1.0 Omnipath 17081983 20166139 18767875 17322306 1650359 11162562 1560845 19413330 19664995 8034575 6957862 21762971 18578522 91317794 20068231 11930178 18452278 17570479 16116087 18491316 18669648 17962038 8557118 17287340 15316066 8422248 19651622 20058876 15239673 17924679 2473066 19664994 18707149 18510355 15212693 18212344
PRKCA SDC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9244383 19901323
FN1 ITGA8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 7559467 7626807
FN1 ITGA9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11839764
FN1 SDC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10772816 1077281610772810
FN1 ITGA2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8663002
PPP1CA CDC25C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9543386 14592972 11897663 16467385
GSK3B DVL3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
GSK3B NOTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 28.0 1.0 Omnipath 16944320 15465828 11967263 14663202 8524413 20068231 12794074 21828089 17570479 9832503 15020233 18669648 15302935
GSK3B GYS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 34.0 1.0 Omnipath 17145710 19651622 6772446 12615961 24165324 18691976 10481074 14593110 15791206 19664994 11427888 17570479 2117608 16282323 18669648
PPP1CA RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 12202491 8380224 17274640 10773440 9315635 17008050 20694007 8384581 16189514 8380637 10889204 12434308
MAML1 NOTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11101851
MAML3 NOTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 12370315
NOTCH2 RBPJ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 25609649 26186194 23331499 26496610 9032325 12370315 11518718
MAML1 RBPJ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 23022380 16530044 25609649 26186194 11101851 17145710 16921404 12644465 21475249 26496610 11997524
NRTN RET â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 9192898 9182803 91828039192898
ARTN RET â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9883723
NRAS FGFR4 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
LAMC1 ITGB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 7721947 10671376 11733063 32196115
LAMB1 ITGB4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 7721947 11733063 10842354 32196115
BMP1 COL5A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11741999 20979576
E2F3 RB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19015245 9711036 24287699 16449662
RB1 E2F3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 17380128 8657117 17488475 10779361 7739537 8832394
RB1 E2F2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 16360038 17380128 12502741 8657117 17488475 8246996 16189514 22569856 7739537 8832394
OTX2 FGF8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17060451 11124114 23145006 19603509 15790971
FGF17 FGFR4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 10751172 16597617 25772309
LAMA1 ITGA7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11278916
LAMA1 ITGB8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 7542940
COL5A1 SDC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11751872