Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
LRRK2 BAG2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29513927 201700444
BAG2 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7834747 8692945
SFN BAX â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 11574543 5214598
CAPN2 BAX â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 21887410 23242420
BAX GSK3B â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 0912742107 20080742
XRCC6 BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18710944
BAX AIFM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12232790
AMBRA1 BCL2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 intact 8174954 21358617
BCL2 AMBRA1 â—¼   PROXIMITY 2.0 0.8 intact 8174954 21358617
HSP90AA1 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18266962
EIF4G2 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18450493
CAPN2 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12000759
SOD1 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15233914
BCL2 XRCC6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18313378
BCL2 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15210690
NRF1 CCND1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0603363103 16864783
ATF4 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18729081 20101207
CDC37 APOE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 21163940 114280
COPS5 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18926707
DVL2 CSNK1E â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
HSP90AA1 DNAJA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8204010 21360678
E2F1 FLT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20516113
E2F1 ATP5PF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15897325 18319725
E2F1 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19303924
E2F1 ACTG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15897325 18319725
DNAJC3 EIF2AK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 25329545 12446838
PRKDC EIF2AK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19451221
EP300 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23403292 24998469
ESR1 EP300 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16704985 11279135
MEN1 TERT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12837246
MYC FGFR3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CEBPA MYC â—¼   DOWN_REGULATES ✅ - 2.0 0.8 ACSN 11340171 20581311
MYC VCAM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11318876 10528192
MYC EGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18365874 11509655
ESR1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 3677090
MYC CFLAR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15367674 11359904
MYC TERT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9988278
ESR1 PRKCD â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22430216 18414489
CSNK2A1 PRKDC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20711232
PRKDC UPF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18158334
SMARCB1 FGFR3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
VCP TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
ACTG1 TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
CDK6 CCND3 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
EGR1 CCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24337575 18281687
ESR1 CCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20404154 17932106
HSPB1 CRYAA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 11700327 5214764
DCTN3 ACTR10 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15473859 15738427
DCTN1 CRYAB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 26465331 0133994
EIF2S1 EIF2AK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 9431994 6735217
EIF2S1 EIF4G2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16932749 5219000
EIF2S1 EIF2AK2 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 9431994 6735217
NRF1 EIF2S1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16230352
EIF2B3 EIF2S1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16288713 15054402
EIF2B3 EIF2S2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16288713 15054402
NRF1 EIF2S2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16230352
ESR1 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23403292 24998469
FGFR3 DVL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
DVL2 EIF1B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8153045 21516116
NCK1 ATP2A3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
NCK1 C6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
EGR1 MST1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23337910 22095683
EGR1 LMTK2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15289351
ESR1 BMI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24559156 16582100
PRKCA HDAC6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8307255 21952047
PRKCA CACNA1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8380626 9278528
ESR1 CTSD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 6771293
CEBPA SOD1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9426001 9013901
CFTR CANX â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12208510 5215704
PPP1CA CCND3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16331257
DCTN1 HDAC6 â—¼   COLOCALIZATION 2.0 0.8 intact 5215415 12024216
DCTN3 ACTR1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15473859 15738427
GSK3B APC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 10698523
CYP2C8 APOE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 21163940 114280
ESR1 BDNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16262660 7479947
ESR1 EPHB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17685427 20484412
ESR1 CYP2C9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24960263 21493749
BTF3 EPHB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17312387
PPP1R15B PPP1CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
C9 SOD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CKAP4 DNAH7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
CALM3 DLG4 â—¼   PHYSICAL_INTERACTION 804.0 0.8 STRING 36370105
CALM1 DLG4 â—¼   PHYSICAL_INTERACTION 804.0 0.8 STRING 36370105
ACTR1A DCTN3 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
ATF4 CREBBP â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
TRAF6 GSK3B â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 31594754 30711629 31754475 30806153
CREBBP FGFR1 â—¼   PHYSICAL_INTERACTION 810.0 0.81 STRING 36370105
CASP8 TRAF6 â—¼   PHYSICAL_INTERACTION 816.0 0.81 STRING 36370105
DVL1 DVL2 â—¼   PHYSICAL_INTERACTION 817.0 0.81 STRING 36370105
COX4I1 COX8A â—¼   PHYSICAL_INTERACTION 818.0 0.81 STRING 36370105
ARAF AIFM1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 29777862 25852190
CFTR CDC37 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 26618866 31324722
FGFR1 CDC37 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31980649 18022941
CDC37 ERBB2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 25036637 24189400
HDAC6 EP300 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 19344692 15102857 12718889 22778253 23133622
MYC ILF2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 30415952 29467282
MYC XRCC5 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17314511 29467282
MYC PRKDC â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17314511 29467282
MYC DCTN1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17353931 29467282
MYC CKAP4 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21150319 29467282
PPP1R15A PPP1CA â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 5217094 15231748
TRAF6 DDX3X â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17353931 27507811
VCAM1 XRCC5 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
VCAM1 XRCC6 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
VCAM1 HBG2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
VCAM1 ILF2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
BMI1 ILF2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 24457600 34316702
CRYAB MAP1B â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 26186194
LRRK2 HSPB1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 24725412 29519959
LRRK2 AIFM1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31046837 24725412
LRRK2 ADRM1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31046837 24947832
IGF1R ERBB2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17307140 30898150
BMI1 ILF3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 24457600 34316702
ESR1 CAND1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 19805454 31527615
CFTR AIFM1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 26618866 17110338
CFTR DCTN1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 26618866 31324722
ESR1 DDX3X â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 20308691 21182205 19805454 20348541
VCAM1 HSPB1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
VCAM1 DDX3X â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
VCAM1 ILF3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
VCAM1 HBG1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
LMTK2 PPP1CC â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
DNAJA2 HSP90AA1 â—¼   PHYSICAL_INTERACTION 822.0 0.82 STRING 36370105
ADRM1 VCP â—¼   PHYSICAL_INTERACTION 825.0 0.82 STRING 36370105
ARAF BAG2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 29777862 31980649 25852190
BAX XRCC6 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 19177010 21042904 19118032 19247369 15205477 25299772 18784078
MYC HSPB1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 21150319 17314511 29467282
LRRK2 PRKDC â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 19826009 31046837 17400507
VCAM1 PRKDC â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 22623428 33961781 19738201
BMI1 XRCC5 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 20668194 24457600 34316702
ATF4 CEBPA â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 23661758 20102225
ESR1 LYAR â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 21182205 33731348 31527615
RNF43 DVL2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 32103169 25825523 25891077 32965059
FLT1 FLT4 â—¼   PHYSICAL_INTERACTION 829.0 0.83 STRING 36370105
HDAC6 CFTR â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 31501480 22069321 14675537
ESR1 ACTN1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 23403292 21182205 19805454 31527615
EIF2B5 EIF2S1 â—¼   GTPASE_REACTION ✅ + 0.83 0.83 Signor 15054402
ACTR10 DCTN3 â—¼   PHYSICAL_INTERACTION 834.0 0.83 STRING 36370105
CCND1 EP300 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
EIF2B3 EIF2S1 â—¼   GTPASE_REACTION ✅ + 0.83 0.83 Signor 15054402
CALM3 ESR1 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
EP300 ILF3 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 20808282 33742100
EP300 XRCC6 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 15023334 33742100 21988832
MYC TERT â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 32140074 28628118 28205554
HSPB1 CRYAB â—¼   PHYSICAL_INTERACTION ✅ 0.84 0.84 mint 5214764 11700327
ESR1 IGF1R â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 10749889 24051437 14764897 28555617 16113100
PTPN11 ERBB2 â—¼   DEPHOSPHORYLATION ✅ - 0.84 0.84 Signor 32024694
EIF2B3 EIF2S2 â—¼   GTPASE_REACTION ✅ + 0.84 0.84 Signor 15054402
GSK3B CDC37 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 23455922 29568061 33961781
ILF2 EP300 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 20808282 30110629 33742100
EP300 PRKDC â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 20808282 30110629 33742100
CFTR PRKDC â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 26618866 29924966 17110338
TRAF6 CASP8 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 27810922 16436380 30979779 16920630
CFTR XRCC5 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 26618866 31324722 29924966
CFTR HSPB1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 26627832 17110338 29924966 26618866 23155000
EGR1 EP300 â—¼   PHYSICAL_INTERACTION 850.0 0.85 STRING 36370105
CALM1 ESR1 â—¼   PHYSICAL_INTERACTION 850.0 0.85 STRING 36370105
E2F1 EP300 â—¼   PHYSICAL_INTERACTION 857.0 0.85 STRING 36370105
ATM PRKDC â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 10608806 10464290
CASP8 BCL2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16183855 11406564
ATF4 EP300 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 14630807 17872950 10350644 12471036 16219772
ESR1 MEN1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16651450 31527615
LRRK2 DVL2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 31046837 19625296
HDAC6 ERBB2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 20029029 31980649
ESR1 DNM1L â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 19805454 21217774
CCND1 ESR1 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
COX4I1 NDUFS1 â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
LRRK2 CDC37 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 18367605 22612223 20642453 26355680 16321986 23075850
MYC EP300 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 15616592 16287840 32140074 16126174 17157259 12776737
MYC CDK6 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 22094256 28628118 28205554
XRCC6 ILF3 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 31536960 30585729 21969602
DNM1L GSK3B â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 16189514 9731200
EIF1 EIF2S3 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
CACNA1B CALM3 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
CACNA1B CALM1 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
BBC3 BCL2 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
BAX XRCC6 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
CALM1 CSNK2A1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
EIF2B5 EIF2S2 â—¼   GTPASE_REACTION ✅ + 0.87 0.87 Signor 15054402
CDC37 LRRK2 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
TRAF6 ZRANB1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HuRI 32296183
FLT1 PTPN11 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
CREBBP ESR1 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
CDC37 ARAF â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 25036637 31980649 29777862 24189400 33961781 32707033
BNIP3 BCL2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10381623 7954800 23504944 10625696
EP300 CCND1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 15951563 10567390 11788592
PRKDC ILF3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 20808282 9442054 21969602
MAP1B LRRK2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 24754922 21159966
DLG4 ERBB2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10839362 16713569
ESR1 BTF3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 31527615 18025262
EIF2B4 EIF2S1 â—¼   GTPASE_REACTION ✅ + 0.88 0.88 Signor 15054402
HSP90AA1 TERT â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
XRCC5 ZRANB1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HuRI 32296183
CRYAB HSPB1 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
EIF2AK1 EIF2S1 â—¼   PHOSPHORYLATION ✅ + 0.88 0.88 Signor 10563826
HDAC6 HSP90AA1 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
ESR1 HSP90AA1 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
DNM1L LRRK2 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
MYC XRCC6 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17314511 30415952 29467282
MYC GSK3B â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16247449 11877389 14563837 20713710 19131971 21150319 31638140 8247524 29467282 33541412
ILF2 PRKDC â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 20808282 17389650 9442054
DVL1 DVL2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24643799 28514442 20224554 33961781 26186194 31340145
DCTN1 DCTN3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 26638075 9722614 32814053 33961781 27173435
CANX VCP â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
CFTR VCP â—¼   PHYSICAL_INTERACTION 891.0 0.89 STRING 36370105
E2F1 ATM â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22832221 23993922 12527885
BBC3 BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15574335
E2F1 BBC3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14684737 17263886
E2F1 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11559537 18319725 11704823
PPP1CC BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17145710 17274640 12051739
ESR1 CAPN2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19376833
CCND1 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16061635 9039267 11073968
CDC37 DCTN1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CDC37 CDK6 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 25036637 24292678 9150368 8666233 33961781
ARHGEF1 CSNK1E â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CEBPA E2F1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12869508 11340171 12702500
E2F1 BMI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23796898 17360938 16582100
E2F1 DCC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12629508
E2F1 BNIP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19088195 18096822
E2F1 CCND3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12611887 16300731
E2F1 FGFR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19303924
EP300 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10753885 15123636 15126619
E2F1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11564866 18319725 90001421
E2F1 CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15240700 12389032 18319725
E2F1 EIF2AK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18319725 16275992 12214268
EP300 EGR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15225550 9806899 20089040 20018936
EP300 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19887647 11782371 12738788 25728767 11867769 12479814 23065768 15308690 20388208 14761960 22227247 8799122 20348541 23403292 12714702 11581164 16713569 19838210 18765668 16645043 30418174 12574227
EP300 HDAC6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15102857 19344692
MYC HSP90AA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 28914785 12644583
MYC MEN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC ACTG1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC CXCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC PDHA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC COX7A2L â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12747840
MYC PRKDC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC GSK3B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
CEBPA MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12873812
MYC CEBPA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12873812
PRKCD PRKDC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19737086 9774685
XRCC5 PRKDC â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15941674 10750018 20023628 17308091 15758953 20085707 33005030 10446239 26496610 19303849 20711232 9312071 26446488 15520013 28154079 28345663 16857680 12393188 22404984 21679440 26344197
XRCC6 PRKDC â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 20711232 21575865 33005030 28345663 15941674 10064605 26496610 26446488 15520013 10750018 8422676 26175416 22939629 17308091 30585729 19303849 21969602
PRKDC VCP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16140914
PTPN11 TERT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19737086 21799948
XRCC6 XRCC5 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15910003 19177010 28514442 28035050 14681455 10750018 17159921 25574025 17308091 10984620 11196700 32296183 7699019 33005030 15367688 12145306 19118032 10446239 26496610 19906305 26774286 10207052 21454661 18809223 9488450 26446488 15520013 30021884 22939629 17283121 10219089 10757784 21070772 11493912 21172662 15023334 22863883 22451927 21679440 24981860 10783163 33961781 30585729 26344197
ATF4 EIF2AK2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23009153 21146245 17141186
EIF2B5 EIF2S2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10805739 15054402 9446619
ANXA7 DVL1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
DVL1 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10428961 16914735 20837657
CASP8 CFLAR â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 22322857 24438025 12097160 33469115 19416807 22864571 9208847 9326610 17159907 11741985 15280356 19710364 21737330 31046799 21737329 9289491 17047155 9228018 12887920 9380701 33961781 26186194 12215447 19343040
EIF2S1 EIF1AX â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 641056 592399 429297
EIF2B4 EIF2S1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16288713 8887689 15054402
EIF2S2 EIF1AX â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 641056 592399 429297
EIF4G2 EIF2S2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 29530922 16932749
FGFR1 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 25241761 15929978
PRKCA CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11463380 17570479 20577053
LRRK2 DNM1L â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 22228096 22639965 24282027 29541021 23813973
EGR1 SOD1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12517959 9867871
PRKCA GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19836308
EIF2S3 EIF1AX â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 641056 592399 429297
CSNK2A1 EIF4G2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 29530922
BZW2 GSK3B â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
GSK3B DCTN3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
PPP1CA PPP1CC â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
THAP12 DNAJC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9447982 16189514
EIF1AX EIF2S3 â—¼   PHYSICAL_INTERACTION 904.0 0.9 STRING 36370105
EIF2AK2 EIF2S1 â—¼   PHYSICAL_INTERACTION 905.0 0.9 STRING 36370105
EIF2AK4 EIF2S1 â—¼   PHOSPHORYLATION ✅ - 0.9 0.9 Signor 32513922
ERBB2 HSP90AA1 â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
ACTR10 DCTN1 â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
EIF1 EIF5 â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
ACTG1 CDC37 â—¼   PHYSICAL_INTERACTION 0.91 0.91 HuRI 32296183
ILF2 ILF3 â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
CCND1 CDK6 â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
HSP90AA1 LRRK2 â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
ARAF MAP2K2 â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
EP300 ESR1 â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
XRCC6 PRKDC â—¼   RELOCALIZATION ✅ + 0.93 0.93 Signor 19133841
CRYAA CRYAB â—¼   PHYSICAL_INTERACTION 0.93 0.93 HuRI 32296183
ERBB2 PTPN11 â—¼   PHYSICAL_INTERACTION 939.0 0.94 STRING 36370105
EIF1AX EIF2S2 â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
EIF2S1 EIF5 â—¼   PHYSICAL_INTERACTION 946.0 0.94 STRING 36370105
C6 C9 â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
DCTN1 DCTN3 â—¼   PHYSICAL_INTERACTION 951.0 0.95 STRING 36370105
PPP1CC PPP1R15B â—¼   PHYSICAL_INTERACTION 953.0 0.95 STRING 36370105
EIF1 EIF1AX â—¼   PHYSICAL_INTERACTION 954.0 0.95 STRING 36370105
EIF1 EIF2S1 â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
EIF1 EIF2S2 â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
CCND3 CDK6 â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
EIF1AX EIF2S1 â—¼   PHYSICAL_INTERACTION 958.0 0.95 STRING 36370105
XRCC6 XRCC5 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 5219440 17159921
XRCC5 XRCC6 â—¼   PHOSPHORYLATION ✅ 0.96 0.96 mint 10783163 5212534
HSPB1 CRYAA â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 11700327 32814053 12601044 33961781
ILF3 ILF2 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 16189514 20808282 23986595 33961781 17389650 26186194 29395067 22939629 26472337 11739746 21969602
ACTR1A DCTN1 â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
LRRK2 SFN â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
CDK6 CCND1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 15232106 16713569 10022865 24855949 17517622 33854235 11739795 14681455 24953629 11360184 33961781 10580009 17420273 21654808 11160398 9178893 19075005
CDK6 CCND3 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 8153045 21516116
CDK6 CCND3 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 16189514 25416956 33854235 14681455 21516116 32296183 17517622 9716181 11360184 30217970 23602568 15232106 26264872 27107012 32707033 16782892 16713569 8114739 29997244 32814053 33961781 26186194
CRYAB CRYAA â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 5214764 11700327
HSPB1 CRYAB â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 18330356 20863832 23532854 23188086 12601044 17916631 26186194 33961781 1560006 11700327 28919577
EIF2S2 EIF5 â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
BAX BCL2 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
PRKDC XRCC6 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
PRKDC XRCC5 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
CASP8 CFLAR â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
BAX BCL2 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 21778226 18981409 15899854 32064756 10620799 21199865 17289999 9194558 8358790 21671007 16642033 21458670 22262057 9388232 10716992 20865015 14980220 9111042 24141421 17097560 15231068 9463381 33961781 17525735 29749471 23479509 26004684
BBC3 BCL2 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 15694340 16697956 14681455 17289999 33961781 11463392 26431330
CRYAB CRYAA â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 17260942 26657544 25416956 32296183 16142923 18639655 22153508 18401461 16760894 25910212 23188086 22085609 22427585 12601044 19651604 11700327 25694240 28919577
ACTR10 ACTR1A â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
SYVN1 VCP â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
CDC37 HSP90AA1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
EIF2B4 EIF2B5 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
CCS SOD1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
MAX MYC â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
XRCC5 XRCC6 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ARAF PPP1CC â—¼   DEPHOSPHORYLATION ✅ 14.0 1.0 Reactome 16294014 21779496 24211266 27264673 19684605 16041367 24347342 16630891 28666118 12932319 11756411 25907612 14530258 28289718
ARAF MAP2K2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 21988832 18039929 24746704 16189514 32296183 25852190 21779497 11909642
XRCC6 ATM â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
XRCC5 ATM â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 22179609 11493912 9512523 11604075 12947387
ATM UPF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17525332 15175154 18158334
ATM E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 20972224 11459832 27679857 15494392 15140942 27028861 21543892 27025900 20860841 24741006 17570479 25101673 28812991 15838517 22174788
ATM EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 20471956 15494392 15140942 29590107 26170237 21108945 15838517 27220480
ATM TRAF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20932475 21872579
ATM PRKDC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 47.0 1.0 Omnipath 17189255 12231622 17303408 24492479 10464290 22230547 15677476 16822724 28985363 29088817 16163361 32868446 19549901 25818648 22923485 19103741 17570479 27939942 19808981 23847781 22355272 24714417 15964794 21376743 31983282 25224041 16908529 12607003 19244120 17525332 15459660 34249431 28107384 12186630 25714019 11877377 26553138 27568553 19535303 15507430 26578593
BCL2 BAX â—¼   PHYSICAL_INTERACTION 15.0 1.0 ACSN 11704864 16227588 17446862 17891140 20709625 21641962 22039431 23064052 23377657 23430059 23850759 7644501 8358790 8929532 9872359
BAX EIF2S3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 ACSN 12601012 12667446 16246152 23850759
BAX EIF2S2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 ACSN 12601012 12667446 16246152 23850759
BCL2 BAX â—¼   PROTEIN_INTERACTION 15.0 1.0 ACSN 11704864 16227588 17446862 17891140 20709625 21641962 22039431 23064052 23377657 23430059 23850759 7644501 8358790 8929532 9872359
BAX EIF2S2 â—¼   SHARES_COMPLEX 4.0 1.0 ACSN 12601012 12667446 16246152 23850759
BAX EIF2S3 â—¼   SHARES_COMPLEX 4.0 1.0 ACSN 12601012 12667446 16246152 23850759
BAX EIF2S2 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 12601012 12667446 16246152 23850759
BAX EIF2S3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 12601012 12667446 16246152 23850759
E2F1 BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9748148 11095619 12370749 14514686 15255934
MYC BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8845569 11103792 12695333
BCL2 BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 60.0 1.0 Omnipath 17145710 22705850 18981409 9463381 21458670 17097560 17525735 8358790 10620799 26004684 29749471 9388232 21199865 17525161 22262057 21778226 15486085 17289999 9111042 12419244 9194558 15231068 10716992 8183370 14980220 9115213 21671007 16642033 23479509 10677502
GSK3B BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 29379583 27762303 15525785 20976235 26287183 17911107 16709574
BCL2 BBC3 â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 11463391 11463392 11704864 17446862 22039431 23064052 23377657 23430059 23850759 8929532
BCL2 BBC3 â—¼   PROTEIN_INTERACTION 10.0 1.0 ACSN 11463391 11463392 11704864 17446862 22039431 23064052 23377657 23430059 23850759 8929532
E2F1 BBC3 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 11463391 11463392 14634023 14684737 15279786 17218262 17303408 17660363 18590585 7575488
MYC BBC3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12695333 12384701 19815507 20145032 21835778
E2F1 BBC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11463391 18319725 11463392 14634023 14684737
BBC3 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 17145710 16697956 15694340 11463392
BCL2 AMBRA1 â—¼   PHYSICAL_INTERACTION 9.0 1.0 ACSN 11704864 17446862 21358617 22039431 23064052 23377657 23430059 23850759 8929532
BCL2 AMBRA1 â—¼   PROTEIN_INTERACTION 9.0 1.0 ACSN 11704864 17446862 21358617 22039431 23064052 23377657 23430059 23850759 8929532
PRKCA BCL2 â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 10677502 10679481 10871288 11323415 16492141 20027184 9115213 9738012
MYC BCL2 â—¼   DOWN_REGULATES ✅ - 17.0 1.0 ACSN 11274345 11283613 11283614 11704864 17055429 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21406394 2191300 22067385 25002027 28536364
CEBPA BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16254192 18987666 23814099 15713621 12970736
MYC BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 8036017 17404573 12695333 24167291 18809243 19201832 16316993 19649202
ESR1 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 19148464 19160418 9306964 11261829 21841772 10542244 20664923 18414489
E2F1 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17404573 11559537 12679318
PRKCA BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 12039060 9115213 12213578 11323415 17610064 9738012 19117992 24212628 10677502
CREBBP BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9829964 10753867 17565603 15337521 10454566
BNIP3 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 17145710 23504944 10625696 10381623 19136941 7954800
BCL2 CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 16183855 11406564
MYC CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 7526316 21933022 17881732 12835716 14757441 19086036 8552398 19698176 19786833 18809243 18806825 8196642 11085504
ESR1 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 11477579 12554765 12808053 17166846 22892083 21505052 18414489 9832502 23864650 22396492 22266855 11358796 23891847 22948256 11986316 15282324 15496458 22521644 14764652 15178330 23108396 11410592 15026472 17998543 17681750 18245487 20821348 16860316 11844790 19858209 12929585 15808510 18997820 15217513 16809759 10500157 16980581 17914104
EGR1 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 23872169 20590664 16926376 19850937 11502738 16267018 16547599 9407106
E2F1 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 10504464 7929342 22768064 19876926 20220142 9584162 17998543 20655656 8618861 8137237 23078099 23543735 10594784
EP300 CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 17306568 17666529 11788592 23343194 21285352 15576399 21151179 22761862 22290435 16039586 19619488 19623618 17143292
GSK3B CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 87.0 1.0 Omnipath 26907733 16944320 27546592 11967263 14663202 8524413 16504004 29969496 19767775 21347341 25142862 11311237 30736789 14597415 25591548 19645770 10385618 20548028 10766840 10929713 23565238 16039586 17570479 18818515 18167338 12615961 12413951 17046823 19071090 18598945 15465828 19374252 26121043 26432751 18319725 12969793 23733133 22922870 24134204 10486203 12459251 15020233 18769147 10910956 11152665 21317297 20537194 22099186 18328826 11124803 17070615 19757160 22470469 23552696 16732330 27695879 29554905 16103118 15075324 14536078 9832503 28090171
DYRK1A CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 26.0 1.0 Omnipath 16504004 33521925 19412162 27285583 19767775 20951943 21241249 20548028 10766840 17046823 26008897 15735756 16601140 16153639 11751903 33854232 18650423 24431113 16732330 16103118 33854239 17081987 24119401
MAX CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 8425218 15121849 2006410 17873522 21406394 12584560 17558397 20551172 15814658 16908182
ESR1 CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8649771 11073968 16061635 9039267
MYC CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 8425218 15121849 2006410 17873522 21406394 12584560 17558397 20551172 15814658 16908182
CCND1 CDK6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 19075005 17517622 9178893 11739795 24855949 15232106 16713569 11360184 10580009 11160398
CCND1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 9190208 10498883 18590585 7575488 9315635 17303408 10385618 10778858 9736735 16236519 20068082 7736585 9425340 11520855 19075565 18786381 17660363 15279786
CSNK2A1 CDC37 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 26755559 18566753 20068231 15082798 18922470 19413330 12930845 27105117
DVL1 CSNK1E â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 Reactome 12556519 21285348 11818547 11425858 10535959 16965538 10517632
DVL2 CSNK1E â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 Reactome 12556519 21285348 11818547 11425858 10535959 16965538 10517632
CSNK1E DVL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 32888647 31515488 22609948 16189514 16713569 10517632
CSNK1E DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 23331499 11425858 20006983 14966280 20215527 16965538 21285348 11487578 11818547
ESR1 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22791811 20215421 12697671 10446910
E2F1 TERT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 21411498 22654424 18818403 11433024 19358274 22207128 16264179 12368233
E2F1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 8208548 2721961 7753559 11705881 24038073 8355712 1549358 1567856 12629508
CDK6 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 9190208 10498883 18590585 7575488 9315635 17303408 10385618 10778858 9736735 16236519 20068082 7736585 9425340 11520855 19075565 18786381 17660363 15279786
CCND3 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 9190208 10498883 18590585 7575488 9315635 17303408 10385618 10778858 9736735 16236519 20068082 7736585 9425340 11520855 19075565 18786381 17660363 15279786
CREBBP E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10753885 15126619 12748276 15123636 8932363
EIF2S3 EIF2AK3 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 18664456 12370288 16288713 17956313 11907036 10026192
EIF2S2 EIF2AK3 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 18664456 12370288 16288713 17956313 11907036 10026192
EIF2S1 EIF2AK3 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 18664456 12370288 16288713 17956313 11907036 10026192
EIF2AK3 EIF2S1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 76.0 1.0 Omnipath 25429617 25579745 14967143 17998059 21981022 27009865 10504407 23356742 3352609 26622781 24316205 24706853 16288713 20408811 30070006 18840095 27638465 21844328 21029306 23293645 21901118 29199180 30081573 14638860 19007793 9819435 23935851 8099443 21029301 19220912 31226023 25660019 22509299 22169477 11337501 24904562 15314157 9930704 23314846 17998206 17325203 16179258 25393282 19583950 26028033 29396442 26487695 10542257 18694499 1677563 11555640 24705207 20040105 24159375 25541374 24958502 11907036 29163417
EIF2AK3 ATF4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19029953 15550948
EIF2AK4 EIF2S1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 22593757 28781602 15684420 10504407 3352609 24706853 20454906 9819435 8099443 15550948 27613409 11337501 32513922 9930704 29281830 21919885 17940089 22355110 16179258 30196486 19583950 28671615 10542257 1677563 25079372 15355306
EGR1 EP300 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20414733 18798221 15635605 15225550
PRKCD EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 11020388 17434128 12379484 15006641 18053091 15212693 12590608
EP300 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 17145710 22290435 19623618 11804596 23343194 22761862 16039586 12776737 17157259 17143292 12660246 15576399 21151179 15522869 17306568 19407812 17666529 21285352 19619488
HDAC6 HSP90AA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19158084 18591380 18266962
MYC MAX â—¼   PHYSICAL_INTERACTION 6.0 1.0 ACSN 11274345 12040186 15121849 16908182 2006410 8425218
MYC MAX â—¼   PROTEIN_INTERACTION 1.0 1.0 HIPPIE 16596619 21988832 10229200 17471507 26267534 15572685 18003922 20382893 35140242 17418410 25609649 16352593 31767764 17072308 17289033 10918583 9528857 14749374 21807113 19623651 18620061 25522242 32296183 16140957 16705173 19578763 26496610 12584560 17157259 17643117 24951594 20946988 10465786 12706874 12821782 9184233 17353931 10611234 32140074 8266081 20691906 16410719 21150319 10593926 12660246 27859590 12553908 8224841 10319872 2006410 16287840 16606833 23816886 9708738 17314511 9886493 27705803 33298911 33961781 20936779 12824180 9680483 17700062 29467282 30415952 12391307
MYC MAX â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 11274345 12040186 15121849 16908182 2006410 8425218
MYC CFLAR â—¼   DOWN_REGULATES ✅ - 19.0 1.0 ACSN 11274345 11283613 11283614 11359904 11704864 15367674 17055429 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21406394 2191300 22067385 25002027 28536364
MYC BMI1 â—¼   UP_REGULATES ✅ + 32.0 1.0 ACSN 11274345 11283614 12545156 14536078 15147722 15155580 15279786 17055429 17303408 17550342 17558397 17660363 17873522 18590585 18636226 20027199 20237412 20551172 20581311 20713526 20818389 21406394 21733352 2191300 21919891 22067385 23140366 23869868 25002027 28536364 7575488 9618481
ESR1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 22396492 21835891 15073177 18193094 11517191 21505052 22892083 8707895 19569049 14722073 18414489
MYC CEBPA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 15681429 17082780 7556187 8076602 20097210 12695333 15867211 19259613
MYC CASP8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15367674 12695333
MYC ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20920219 21627565 7906953 23421821 20716114
MYC TERT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 76.0 1.0 Omnipath 16287840 15655249 12821782 16880523 21807113 19047367 14744757 16489011 12941894 10786671 14519204 19360348 10723141 12970752 15595642 18365874 15665468 22207128 14611815 10022128 15226182 11274400 10491298 11606399 17070091 19787269 19806010 20454512 19762557 21132266 21553143 18818322 10914736 17934056 19148473 11435602 12695333 12802280 21995449 11287602 12044867 21627565 23860446 17942561 19649288 23759068 10606235 12807729 15958520 17141225 20723213 16402390 16785237 18093727 21855630 24705139 18367227 14563552 16205635 19003324 9988278 17706770 17967894 18226852 18754863 10637317 18586674 14612409 19912441 15371341 11916966 12646176 11279234 18158869
MYC ATF4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12695333 23612979
MYC CFLAR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15367674 22266862 11896589 20348907
MYC MAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 10508165 15665468 8385351 8649388 8521822 22384171 1406956 17341548
MYC CDK6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20682794 22395148 12835716
CREBBP MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 7575488 18590585 17303408 15522869 12776737 20144767 17660363 16878156 15279786
GSK3B MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 73.0 1.0 Omnipath 17081983 18463697 21646472 30037819 26751215 25647305 2663470 20080742 19797085 30003124 16855632 12040186 18679417 11018017 23331499 29229669 16611981 21071413 24265759 20068231 10671551 16039586 17570479 16023596 29258530 12615961 18669648 21113395 22461507 19131971 8247524 16247449 20604938 19575820 15150404 22481935 23668310 19651622 17444818 23964270 20537194 22893788 27684546 24662831 25333250 20399964 11877389 14563837 18408012 17052453 18455992 15212693 16371461 11274345
MAX MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 90.0 1.0 Omnipath 17145710 16287840 25609649 12821782 16606833 16596619 21807113 25522242 20691906 19578763 24951594 8224841 17643117 9528857 12391307 16705173 21150319 10229200 21988832 15572685 9680483 2006410 17314511 14749374 12553908 17289033 17418410 19623651 12824180 17157259 12584560 26496610 20946988 20936779 8425218 23816886 17353931 10319872 17471507 18003922 16140957 20382893 12660246 8266081 7565735 32296183 10465786 26267534 17072308 27705803 9184233 18620061 10918583 17700062 10593926 10611234 16352593 9708738
SMARCB1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10319872 14559996 14964309 19234532
ATF4 PPP1R15A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19564919 23907468 12840028 31226023
PPP1R15A PPP1CC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 14670976 23331499 14718519 27629041 11564868
PRKCD EPHB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 17496910 11940581 21386996 11447289 19615955 16488589 6321473 8321321 12845332 11313945 12040186 19568798 15567848 14585353
PRKCD IGF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 17496910 11940581 21386996 11884618 11447289 19615955 16488589 6321473 8321321 12845332 11313945 12040186 19568798 15567848 14585353
PRKCD DNM1L â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 25012575 33941653 27831567 34394840 29022905 31949126 30091204 28314909 17301055 21119009 31308800 31992853 33126710 33802063 32433544 26306039 33850876 31744518 33850055 34307369 18838687 21822277 21646527 31356754 33476635 24561342 33940381
PRKCD CARD9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 29352133 22265677 27926862
ALK PTPN11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 18320059 19223540 15710330 12522270 12531430 11684012 34301842 8041791 12721296 17483340 32076487
PRKCA PTPN11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 16055440 11781100
PTPN11 ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 9756944 16273093 16729043 32024694
PTPN11 PTK2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 10880513
PTPN11 IGF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 28065597 23331499 11779860 7642582 10082579 8895367
ESR1 TERT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 21411498 12122114 21693539 18519947 16690106 10805720 19360348 23409030 18754863
CD36 TRAF6 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 18070982 15247281 21220427 12140561 12138165 8837778 19592497 18347055
EIF2S2 ATF4 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 12601012 12667446 16246152 23850759
EIF2S1 ATF4 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 12601012 12667446 16246152 23850759
EIF2S3 ATF4 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 12601012 12667446 16246152 23850759
ATF4 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11564156 9295363 25241761
GSK3B CDK6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 11152665 20537194 10385618 11124803 12969793 19757160 16732330 10486203 16039586 14536078 18167338 12459251 12615961
CCND3 CDK6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 17517622 8114739 26186194 27107012 23602568 10477583 16782892 21516116 25416956 29997244 31515488 32814053 15232106 32296183 11360184 16713569 9716181
CSNK2A1 CALM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 25108821 11827172 8206911 1520270 17173306 17329434 26675311 8639568
CSNK2A1 EIF2B5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 11500362 18669648
GSK3B EIF2B5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 50.0 1.0 Omnipath 19007248 17081983 20166139 12133000 21798082 19413330 15302935 18701453 24023715 20068231 18452278 17570479 18669648 9468292 18691976 18088087 19651622 11500362 19664994 16097034 18707149
ITGA4 PTK2B â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 12626562 19161977 19454690 19487819 22470492 9003039 9456329 9763606 9973479
VCAM1 ITGA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 22623428 19738201 11751331
DVL1 GSK3B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
DVL1 CSNK2A1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7744250 21285348 10698942 9192851 9214626
CSNK2A1 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 10837139 20976471 10806215 25241761 20558317 10671551 17374729 21285348 11972058 21506126 11689703 10747897 16707567
DVL1 LRRK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 20006983 19625296
CSNK2A1 MAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 19651622 11535131 17081983 8247525 8018564 18691976 9115440 20068231 18452278 19413330 7735324
AIFM1 NDUFS1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 ACSN 15526035 16200211 16218961 16489074 17344420 20025615 20816094 24684389
AIFM1 NDUFS1 â—¼   SHARES_COMPLEX 8.0 1.0 ACSN 15526035 16200211 16218961 16489074 17344420 20025615 20816094 24684389
AIFM1 NDUFS1 â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 15526035 16200211 16218961 16489074 17344420 20025615 20816094 24684389
PDHA1 DLD â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11752427 2188967 11935326 9242632
CFLAR CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 42.0 1.0 Omnipath 22864571 17145710 19416807 9217161 9326610 11741985 15280356 14585074 17047155 9794838 9208847 24438025 9289491 19710364 21737330 19343040 9228018 17159907 26186194 9380701 9880531 22421964 21737329 12887920 12215447 12097160 15024054
EIF2S1 EIF2S2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 ACSN 12601012 12667446 16246152 23850759
EIF2S1 EIF2S3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 ACSN 12601012 12667446 16246152 23850759
EIF2S1 EIF2S3 â—¼   SHARES_COMPLEX 4.0 1.0 ACSN 12601012 12667446 16246152 23850759
EIF2S1 EIF2S2 â—¼   SHARES_COMPLEX 4.0 1.0 ACSN 12601012 12667446 16246152 23850759
EIF2S1 EIF2S2 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 12601012 12667446 16246152 23850759
EIF2S1 EIF2S3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 12601012 12667446 16246152 23850759
PPP1CC EIF2S1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17145710 21622569 9023344 27629041 9694816 12941928
EIF2AK2 EIF2S1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 85.0 1.0 Omnipath 28167698 11432733 28781602 20685959 9335428 10504407 3352609 24178712 25687824 17290288 24706853 16288713 19043413 19259124 23399035 21738672 8626809 9431994 21899699 11985496 2912723 23259068 28670265 19364808 2116318 9819435 23706307 8099443 8096514 31226023 18096616 15550948 8099444 17372663 24335187 11337501 9930704 21377708 23056444 21418572 18971339 16179258 20149255 19583950 28623239 10542257 21368187 1677563 22174864 11452027 24909749 20040105 12737801 16179259 16289913 25521494
EIF2AK1 EIF2S1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 37.0 1.0 Omnipath 28781602 10504407 3352609 11041858 24706853 16288713 28670265 2116318 9819435 8099443 15550948 11337501 9930704 16179258 19583950 10542257 10563826 1677563 24714526
PPP1CA EIF2S1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 21622569 9694816 9023344 12941928
EIF2S2 EIF2S3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 ACSN 12601012 12667446 16246152 23850759
EIF2S2 EIF2S3 â—¼   SHARES_COMPLEX 4.0 1.0 ACSN 12601012 12667446 16246152 23850759
EIF5 EIF2S2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 10805737 11092890 9395514 16189514
CSNK2A1 EIF2S2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 16225457 19651622 17081983 18691976 20068231 18452278 8024572 22113938 18669648 12901717
EIF2B4 EIF2S2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16288713 15054402 16189514 9446619
CREBBP ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9192902 18765668 16417649 11113179 8616895 11782371 14766010 17400812
DVL2 LRRK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 20006983 19625296
DVL2 GSK3B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
DVL2 CSNK2A1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7744250 21285348 10698942 9192851 9214626
PRKCA DVL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 12958364 11940581 21386996 11313945 15567848
EGR1 FLT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10669633 10828020
EGR1 EGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 22198386 22593802 19913601 10395376 18844239 22433566 20472833 24470481
ESR1 EGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10894157 15075211 20889718 8770893 19423651
EGF ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15748904 23331499 12093292 11279155
EGR1 APOA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8175747 7896852 12107072
CSNK2A1 EGR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 8662759
ESR1 IGF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17170218 20021813 16087727 19250214 10982795 24281069 18414489 15595626
PRKCA ADAM17 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 12958364 11940581 21386996 23955714 20188673 26806653 12058067 11313945 21570469 21586567 18187448 15567848 18722532
CCS SOD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10677207 12968035 9726962
PRKCA CFTR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 92316961 15212693 26888287 1377674
PRKCA EPHB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 17496910 11940581 21386996 11447289 19615955 16488589 6321473 8321321 12845332 11313945 12040186 19568798 15567848 14585353
PRKCA ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 17496910 11940581 21386996 11447289 19615955 16488589 6321473 8321321 12845332 11313945 18799465 9855018 12040186 19568798 15567848 14585353
ESR1 CTSD â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 7786196 19383337 19569049 16219765 8524236 9731700 11165043 18414489 2350335 10037443 8195246
PTK2B GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 26274564 10601262 16452634 24931005
CEBPA APOA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15109267 1900840
GSK3B CEBPA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 20194724 23181522 28775290 10567568 21038412
CSNK2A1 CFTR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 21930781 17289674
DDX3X PABPC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18596238 21883093 22872150
GSK3B CCND3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 22.0 1.0 Omnipath 11152665 20537194 10385618 15252116 11124803 16331257 12969793 19757160 16732330 10486203 16039586 14536078 18167338 15326477 12459251 12615961 17092340 15212693
CSNK2A1 EIF5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 19651622 19415658 17081983 16227438 18691976 11861906 20068231 18452278 17287340 19413330 18669648 18649047
CSNK2A1 CARD9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 17936701
CSNK2A1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 11139588 26703694 9337862 20043841 11432835 11507039 9528769 7838153
GSK3B CIITA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17991736
GSK3B MAP1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 27849007 25775433 15731007 17570479 9570753 25040932
GSK3B ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 10428798 10949034 17609434 15461668 9528769 12118371 15059947 16076840 17570479 7491495 12093745 8308015 15212693 15528270 7838153
ESR1 ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 24559156 16115928 16467118 17992604 19915977 15199112 21127199 21761336 21907803 20551150 11713584 1358436 20629094 18768663 19005469 9242384 20889718 10698518 16467117
ERBB2 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 15173068
ESR1 HSPB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15833836 10960840 11174852 8923463
ESR1 APOA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11013347 18005483 9535920 17532863 23293065
ESR1 CYP1A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 16972788 16010691 17511620 15858227 15837795 20716622 22837390
ESR1 NRF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18048642 21486948 23892277
LMTK2 PPP1CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 12202491 24120663 23331499 17283141 16785988 17202132 12393858 21996745 18250156 29764992 22220831
DNAJC3 EIF2AK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 25329545 9447982 8576172
EIF2AK2 ILF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 11438540 10400669 10684936 11438536 10320367
C9 C6 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9038722 16999828 7691959 17505110 16079145