PAK1
|
RAF1
|
â—¼ PHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
intact
|
17097642
5219317
|
EIF4A2
|
EIF4E
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17353931
|
RAF1
|
RELA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
30761125
27554335
|
RPS6KA5
|
RELA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5216210
12628924
|
PDPK1
|
PRKCA
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
12840507
9889098
|
PABPC1
|
EIF4A1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
0914856107
20133758
|
EIF4H
|
EIF4A1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11418588
19203580
|
EIF2S2
|
EIF4A1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
804.0
|
0.8
|
STRING
|
36370105
|
C11orf68
|
EIF4H
|
â—¼ PHYSICAL_INTERACTION
|
|
|
804.0
|
0.8
|
STRING
|
36370105
|
MCC
|
CSNK1E
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.81
|
0.81
|
mint
|
21900206
2001699
8089645
|
EIF2S3
|
EIF4A1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
813.0
|
0.81
|
STRING
|
36370105
|
EIF2S2
|
EIF4G1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
823.0
|
0.82
|
STRING
|
36370105
|
EIF2S1
|
EIF4G1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
826.0
|
0.82
|
STRING
|
36370105
|
EIF2S1
|
EIF4A1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
829.0
|
0.83
|
STRING
|
36370105
|
EIF4B
|
EIF4G1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
829.0
|
0.83
|
STRING
|
36370105
|
PABPC1
|
EIF4G1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.84
|
0.84
|
mint
|
9857202
6548418
|
EIF4E
|
PABPC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
849.0
|
0.85
|
STRING
|
36370105
|
OTUB1
|
PCNA
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
26752685
18954305
|
EIF4A1
|
EIF4A2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
870.0
|
0.87
|
STRING
|
36370105
|
PAK1
|
RAF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
17097642
9823899
12551923
10205168
9234708
11733498
|
RAF1
|
PAK1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
15520807
17462920
20363321
|
EIF2S1
|
EIF1AX
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
641056
592399
429297
|
EIF2S2
|
EIF1AX
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
641056
592399
429297
|
EIF2S3
|
EIF1AX
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
641056
592399
429297
|
EIF4A1
|
EIF4E
|
â—¼ PHYSICAL_INTERACTION
|
|
|
903.0
|
0.9
|
STRING
|
36370105
|
EIF1AX
|
EIF2S3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
904.0
|
0.9
|
STRING
|
36370105
|
EIF4A2
|
EIF4G1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
908.0
|
0.9
|
STRING
|
36370105
|
EIF1AX
|
EIF4A1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
926.0
|
0.92
|
STRING
|
36370105
|
EIF1AX
|
EIF2S2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
943.0
|
0.94
|
STRING
|
36370105
|
MAP2K2
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
958.0
|
0.95
|
STRING
|
36370105
|
EIF1AX
|
EIF2S1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
958.0
|
0.95
|
STRING
|
36370105
|
EIF4G1
|
EIF4A1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.96
|
0.96
|
mint
|
5219000
16932749
|
EIF4E
|
EIF4G1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
981.0
|
0.98
|
STRING
|
36370105
|
EIF4G1
|
PABPC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
987.0
|
0.98
|
STRING
|
36370105
|
EIF4A1
|
EIF4G1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
992.0
|
0.99
|
STRING
|
36370105
|
IKBKE
|
RELA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
24.0
|
1.0
|
Omnipath
|
28317833
12842894
16046471
20188669
15128824
17561400
17003035
30223576
15485852
10521409
15489227
15849198
16407239
26025205
15212693
12767944
|
PDPK1
|
PAK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
20.0
|
1.0
|
Omnipath
|
11134074
21726627
21209852
10995762
23885116
26009991
26238471
10551809
25335797
|
PAK1
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
67.0
|
1.0
|
Omnipath
|
28007610
19421139
26333361
22096607
15849194
12952546
30197477
12551923
23162742
25733387
17097642
22105362
18465753
23331499
24924700
10801448
26257058
21917714
12719581
11376654
25843685
15664191
19165420
23576562
23506953
10205168
24505617
28415790
18775988
22983922
9234708
12952943
16129686
25472536
11733498
11948406
9823899
11897507
|
SYK
|
PRKCA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
9531509
20068231
12881490
17192257
15583006
|
EIF2S1
|
EIF4E
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
641056
592399
9732867
6853548
|
EIF4E
|
EIF2S2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
641056
592399
9732867
6853548
|
EIF4E
|
EIF1AX
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
641056
592399
9732867
6853548
|
EIF4E
|
EIF2S3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
641056
592399
9732867
6853548
|
PRKCA
|
EIF4E
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
1911648
8662663
2355012
12897141
9155017
17570479
11723111
95301551
11463832
9878069
|
EIF4G1
|
EIF4E
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
37.0
|
1.0
|
Omnipath
|
17145710
8521827
22509910
17689282
23665581
22586265
16648488
16467844
9372926
16541103
15361857
16720573
9418880
16281055
18955708
12071973
21191102
26186194
10753870
15153109
10600798
7651417
20212144
|
PRKCA
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
27.0
|
1.0
|
Omnipath
|
1386920
23331499
9447975
8321321
12551925
8288587
7935389
12917261
9922370
15664191
93309588
1437148
|
RAF1
|
MAP2K2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
47.0
|
1.0
|
Omnipath
|
7565670
12750173
18799465
16364241
11909642
19219045
21988832
23331499
15342917
8933152
9671314
8393135
9808624
8223433
16189514
18988627
18669648
19541618
16293107
10969079
10567369
8157000
11136732
11948414
7898932
9069260
18039929
19369195
8607979
10327068
17116858
24746704
12920017
16129686
19058874
15466214
|
EIF2S1
|
EIF2S2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
ACSN
|
12601012
12667446
16246152
23850759
|
EIF2S1
|
EIF4H
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
641056
592399
9732867
6853548
|
EIF2S1
|
EIF2S3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
ACSN
|
12601012
12667446
16246152
23850759
|
EIF2S1
|
EIF4B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
641056
592399
9732867
6853548
|
EIF2S1
|
EIF4A2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
641056
592399
9732867
6853548
|
EIF2S1
|
EIF2S3
|
â—¼ SHARES_COMPLEX
|
|
|
4.0
|
1.0
|
ACSN
|
12601012
12667446
16246152
23850759
|
EIF2S1
|
EIF2S2
|
â—¼ SHARES_COMPLEX
|
|
|
4.0
|
1.0
|
ACSN
|
12601012
12667446
16246152
23850759
|
EIF2S1
|
EIF2S2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
ACSN
|
12601012
12667446
16246152
23850759
|
EIF2S1
|
EIF2S3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
ACSN
|
12601012
12667446
16246152
23850759
|
EIF2S2
|
EIF2S3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
ACSN
|
12601012
12667446
16246152
23850759
|
EIF2S2
|
EIF4H
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
641056
592399
9732867
6853548
|
EIF2S2
|
EIF4A2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
641056
592399
9732867
6853548
|
EIF2S2
|
EIF4B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
641056
592399
9732867
6853548
|
EIF2S2
|
EIF2S3
|
â—¼ SHARES_COMPLEX
|
|
|
4.0
|
1.0
|
ACSN
|
12601012
12667446
16246152
23850759
|
RPS6KA5
|
RELA
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
Reactome
|
17462920
12628924
19197368
19122653
18385332
|
RELA
|
FN1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
10649441
18064631
10867646
22223884
12372417
|
RELA
|
VCAM1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
21.0
|
1.0
|
Omnipath
|
10833420
20966071
16317091
7536741
16627481
16385502
10946302
19422386
22708120
23042817
19281832
10553096
10329958
11359843
7692229
16249517
10496926
7537851
16453001
|
RPS6KA5
|
RELA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
33.0
|
1.0
|
Omnipath
|
17145710
27768872
19197368
22187158
20204068
22216091
19706715
30240634
25241761
11931769
19910110
21791059
23536830
23485395
22312446
19789307
24705157
27009097
17255956
12628924
|
EIF4B
|
EIF1AX
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
641056
592399
9732867
6853548
|
EIF4B
|
EIF2S3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
641056
592399
9732867
6853548
|
PDPK1
|
PRKCA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
15209375
11078882
10698939
9889098
|
PDPK1
|
MAP2K2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
15175348
15466476
|
EIF2S3
|
EIF4H
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
641056
592399
9732867
6853548
|
EIF2S3
|
EIF4A2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
641056
592399
9732867
6853548
|
EIF2S3
|
EIF4G1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
641056
592399
9732867
6853548
|
EIF1AX
|
EIF4H
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
641056
592399
9732867
6853548
|
EIF1AX
|
EIF4G1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
641056
592399
9732867
6853548
|
EIF1AX
|
EIF4A2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
641056
592399
9732867
6853548
|
PABPC1
|
EIF4G1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
19716330
17145710
16772376
12086624
9857202
|