Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
ACTR2 ACVR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 16446785
FXR2 AP2M1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
AP2S1 AP2M1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 15749704 15911768
MED4 AP2M1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
AP2M1 AP2A1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 15749704 15911768
AP2M1 AP2B1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 15749704 15911768
AP2S1 AP2M1 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 15749704 15911768
AP2M1 AP2A1 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 15749704 15911768
AP2M1 AP2B1 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 15749704 15911768
PDGFRB CBL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6731806 17620338
ITCH CBL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12226085 5215735
CBL ASAP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17255943 5219572
CBL FGFR3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBL FGFR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBL FGFR4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
HGS EGFR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20308550 0911188107
EGFR HRAS â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
PML EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12673202 9819401
EGFR GRK2 â—¼   COLOCALIZATION 2.0 0.8 intact 5217433 15620700
EGFR DNAJC13 â—¼   COLOCALIZATION 2.0 0.8 intact 21510942 8152869
EPN1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19054389
SH3KBP1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11894095
EGFR HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 17673906
EGFR ARF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24797263 20029029
RABAC1 FXR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
RTN4 FXR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
RTN3 FXR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
FXR2 DNM2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
HGS ARRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 23208550 8428323
HGS MVB12A â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 14624836 15218037
HGS ARRB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 23208550 8428323
HGS MVB12B â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 14624836 15218037
FHIP1B RABAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
ARF6 PIP5K1A â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 12447393 15817676
ARF6 PIP5K1C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12847086
ARF6 PIP5K1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16189514 10589680
ARAP1 ARPC3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
LDLRAP1 AP2B1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
PLIN3 SMAD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
EEA1 IGF2R â—¼   COLOCALIZATION 2.0 0.8 intact 16977309 5219086
IGF2R TGOLN2 â—¼   COLOCALIZATION 2.0 0.8 intact 16977309 5219086
ARF1 GBF1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8810314 9614177
ARFGEF2 ARF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8945478 8945477
HRAS CAV1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8621645 5220985
HRAS CHMP7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
IL2RA IL2RG â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15178252 16477002
AP2S1 AP2B1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 15749704 15911768
AP2B1 AP2A1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 15749704 15911768
AP2S1 AP2B1 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 15749704 15911768
AP2B1 AP2A1 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 15749704 15911768
AP2S1 AP2A1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 15749704 15911768
AP2S1 AP2A1 â—¼   SHARES_COMPLEX 2.0 0.8 ACSN 15749704 15911768
RHOA KIF5A â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10913441 11689693
RHOA PIP5K1C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10592173 14681219
CBLB ASAP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17255943 5219572
CBLB ASAP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17255943 5219572
CBLB PDGFRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBLB FGFR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBLB IGF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBLB FGFR4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBLB FGFR3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
ITCH CBLC â—¼   COLOCALIZATION 2.0 0.8 intact 12226085 5215735
CBLC PDGFRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBLC FGFR4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBLC FGFR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBLC FGFR3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
CBLC IGF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
GRK5 CXCR4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24632620
PRKCI PARD6A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5213720 11257119
ARAP1 FGFR3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
FGFR3 CHMP7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
DNM2 SH3GL1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10542231 5211933
GRK2 GIT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18369319 6608764
GRK2 GIT1 â—¼   COLOCALIZATION 2.0 0.8 intact 18369319 6608764
RAB11FIP3 RAB11A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18511905 6799554
RAB11A ARF5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17030804 0605357103
RAB11FIP2 RAB11A â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
ARFGEF2 ARFGEF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19332778 0901558106
AGTRAP ARFIP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8153045 21516116
RBSN RAB4A â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
EPS15L1 EPN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9723620
SNX1 F2R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16189514 12058063
SH3KBP1 ASAP1 â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 5219572 17255943
SH3KBP1 ASAP1 â—¼   COLOCALIZATION 2.0 0.8 intact 17255943 5219572
ASAP1 SH3KBP1 â—¼   COLOCALIZATION ✅ 0.8 0.8 mint 5219572 17255943
PDCD6IP CHMP4B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0707601105 18434552
MVB12A SNF8 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 21757351 15218037
SNF8 MVB12B â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 21757351 15218037
SDCBP PDCD6IP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 31138766 24316671
SH3KBP1 ASAP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17255943 5219572
RTN4 RTN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
PLIN3 SH3GLB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
FHIP1B RTN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
HCCS SH3GLB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
REEP6 FHIP1B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
CAV2 EGFR â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
CHMP4A CHMP5 â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
DNM2 DNM3 â—¼   PHYSICAL_INTERACTION 806.0 0.8 STRING 36370105
CAV1 RHOA â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 31871319 20460433 9647788
PARD6A PARD3 â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 5213720 11257119
CHMP1A CHMP5 â—¼   PHYSICAL_INTERACTION 810.0 0.81 STRING 36370105
ARPC1A ACTR2 â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 24981860
EGFR IGF1R â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17047074 17307140
FXR2 SNX1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
ARRB1 HGS â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 23208550 20505072
HGS ARRB2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 23208550 20505072
GPX7 SNX1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
RAB5C ARF1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 26344197
ARF1 ARF5 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33961781 26344197
DAB2 AP2B1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22323290 34079125
FGFR2 FGFR1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
ARRB1 ITCH â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17947233 18544533
ARRB2 AP2A1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 32962859 17620599
LAMP1 RAB4A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
EEA1 RAB5B â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 12493736 10491193
CHMP5 CHMP3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
HCLS1 SNX1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
ASAP3 ASAP1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
REEP5 RTN4 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 33961781
ASAP3 ASAP2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
SMAP1 SMAP2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 32296183 29395067
ARF6 CYTH3 â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
ARPC3 NCKIPSD â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
ARPC2 NCKIPSD â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
ARPC4 NCKIPSD â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
ARF1 IQSEC1 â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
ARF1 IQSEC2 â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
PIP5K1A PIP5K1C â—¼   PHYSICAL_INTERACTION 822.0 0.82 STRING 36370105
CXCR4 ITCH â—¼   PHYSICAL_INTERACTION 823.0 0.82 STRING 36370105
VPS26B VPS35 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HuRI 32296183
CBL ITCH â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 12226085 19341794
EGFR AP2S1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 24797263 25754235 24189400
CHMP6 SNF8 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 14505570 16371348 33961781
CXCR2 ARRB1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 16189514 11170396
IL2RG REEP6 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
ARRB1 IGF1R â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 33158816 15878855 21685939
BIN3 SNX1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
CCNL2 SNX1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
TMOD1 SNX1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
EP300 PCNA â—¼   PHYSICAL_INTERACTION 831.0 0.83 STRING 36370105
ARRB2 CLTC â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
AP2B1 CLTC â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
AP2M1 LAMP1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 34079125 16189514 7569928 16713569
SNX2 EGFR â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 24797263 9819414
MED4 GIT1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 33961781 25281560
RAB5A RUFY1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 34079125 14617813
SNX1 VPS29 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 11102511 26344197
RAB11B RAB8A â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
CHMP1A CHMP4B â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
EHD2 AP2M1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 16713569 15182197
EGFR AP2B1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 24797263 24189400 7534311 23956138
ARF6 ARRB2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 11533043 16189514 11867621
ARF1 ASAP1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 16223492 16332543
CBLC ITCH â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 12226085
SNX2 VPS29 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 11102511 22863883 22939629 26344197
CHMP2A CHMP5 â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
CHMP2B CHMP4B â—¼   PHYSICAL_INTERACTION 853.0 0.85 STRING 36370105
ARF6 CYTH2 â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
IGF1R INSR â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
ARFGAP1 ARF1 â—¼   GTPASE_REACTION ✅ + 0.85 0.85 Signor 10102276
SNX1 EGFR â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 9819414 8638121
PLD1 ARF6 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 34079125 12379803
PLD2 ARF1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 12519790 10801846 11373276
RAB5C CAV1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 34079125 26496610
CAV1 INSR â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 10598578 31217420
ITCH BIN1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 26613292 28235806
RAB11A RAB5A â—¼   PHYSICAL_INTERACTION 859.0 0.86 STRING 36370105
VPS35 SNX1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 11102511 16189514 26344197
ACAP2 RAB35 â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
PDCD6IP SH3GL1 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
EGFR ARRB2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 24658140 25402006 31980649
PLD1 ARF1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 9688545 26344197
AP2A1 AP2B1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 34079125 33961781 26344197
PLD2 CAV1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 14675200 10675563
REEP5 REEP6 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 33961781 34079125 26496610
CLTC HGS â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
EGFR HGS â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
PDCD6IP SH3KBP1 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
EGFR SH3KBP1 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
ARF1 ARFGAP1 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
SH3GL1 SH3GL3 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
RHOA SMURF1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
AP2B1 ARRB1 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
ARAP1 SH3KBP1 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
PARD3 PARD6G â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
EGFR PDCD6IP â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
EGFR AP2A1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 24797263 20029029 24189400 23956138 25754235 7534311 31959764
EP300 SMAD2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 11371641 21988832 10199400 12237408 11264182 15623506
ARF6 RAB11FIP3 â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
ARF1 ARF4 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 33961781 26344197
FGFR2 FGFR3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 23972473 33961781
ARRB2 ITCH â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 17947233 18544533
ARF5 RAB11FIP3 â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
SNX2 SNX1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 11102511 9819414 33961781
SNX1 RTN4 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 25416956 26344197
CAV1 EGFR â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
CYTH2 ARF6 â—¼   GTPASE_REACTION ✅ + 0.88 0.88 Signor 14565977
CHMP6 SNF8 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
CHMP2A CHMP2B â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
ACTR3B ARPC5L â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
RAB11A RAB11FIP5 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
VPS26A VPS26B â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
AP2A1 AP2B1 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
EGFR AP2M1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24797263 20029029 31980649 24189400 23956138 24067654 25754235 31959764
AP2M1 AP2S1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 24189400 33961781 26186194 19380743 26344197
AP2M1 AP2A1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 24189400 33961781 26186194 19380743 26344197
AP2M1 EPN1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 33961781 26186194
CBLB EGFR â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24797263 11375397 20308550 19531499 33848699 10635327 30515972 18271526 28572092 10086340 16729043 31959764 16702950 15657067
EGFR ARF6 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 34079125 24797263 20029029 31980649
EGFR HGS â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 23477725 12953068 20308550 23153581 23602387 25588945 18508924 15212941
EGFR ARRB1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24658140 25402006 31980649
HGS SNX1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16189514 16713569 19874558 11110793
ARF6 ARRB1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11533043 16189514 11867621
SMAD2 DAB2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11387212 16713569
AP2S1 AP2B1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 12086608 16189514 33961781 34079125 26344197
RTN3 RTN4 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 32296183 16189514 25416956 33961781 12811824
ASAP1 SH3KBP1 â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
CHMP4C PDCD6IP â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
CBL EGFR â—¼   UBIQUITINATION ✅ - 0.89 0.89 Signor 20332299
EGFR CBL â—¼   RELOCALIZATION ✅ + 0.89 0.89 Signor 16829981
CAV1 CAV2 â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
ARRB2 AP2M1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 20947020 17199046 12958364
AP2B1 AP2M1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 12086608 16189514 16713569 24189400 33961781 19380743 26186194 30021884 34079125 26344197
EGFR CBL â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 27059931 7657591 8665853 27903975 15107835 24797263 28791635 9756944 23799367 23175185 28198003 12734385 14505571 20940296 19155296 10635327 15117950 22833562 29629558 12061819 8662998 10086340 33762435 11994282 20877636 32714745 25005938 31182136 19578043 7782294 24714105 10799548 23158001 26055326 33617900 23153581 15210722 25872741 15657067 19947936 10428778 18508924 16969069 17971399 15962011 19531499 25521828 23774213 22976291 31959764 22591401 18255265 15735736 16713569 20562913 17880946 16914641 9890970 22394513 16729043 32114396 17995934 17182860 18319245 18271526 17545148 15383614 25140053 32377695 15465819 33627783 8798643 25754235 15282549 26177020 22266821 16923119 17242169 30544639 12604776 11239464 9130710 19225046 11370743 21772844 16105874 18273061 7592693 23897813 17486068 16246327 23457600 32904620 12803489 31120930 15668240 22203672 23418353 20124286 28541302 33323455 10092522 14627991 15677445 15159412 20308550 16849543 12593795 19836242 9121472 19713535 18316398 11408594
CBL IGF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18632619 17635922 10514377
EGFR RHOA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
CBLC EGFR â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 22888118 29945960 10571044 10362357 31959764
EGFR CAV2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31980649 24658140 15273741 25402006 16799092
EGFR CAV1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16407214 19446582 22411794 31980649 12388423 24658140 15273741 25402006 16799092 9374534 34079125 12354760 10781609 15657067
EP300 PCNA â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11268218 16713569 18263614 12937166 24939902 14988403 33742100
PML SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 15356634
PLD1 RHOA â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9565577 12593858 31871319 11311142
ARF6 PLD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 30944160 12379803
ARF1 PLD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16054594 9688545
REEP5 RABAC1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
ASAP2 ARF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10022920 10749932
CAV1 PDGFRB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10066366 11168929 23331499
ACVR1B SMAD2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 11024047 12063393 14978253
ITCH SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15350225 23331499
CYTH3 ARF1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18451304 9707577 10652516
ARF1 CYTH4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18451304 9707577 10652516
ARF1 TFRC â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 22595524 23691193 24376839
ASAP1 ARF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11773070 16223492
ARF1 PIP5K1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16189514 10589680 10747863
ACVR2B SMURF1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12151385 12857866 11278251
ARRB2 AP2B1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21118812 17620599 12070169 10097102
ARRB2 AP2S1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 20947020 17199046 12958364
CBLC SH3GL3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CAV2 CAV1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12414992 16189514 31980649 9361015 18081315 33961781 24013648 10212252
CXCR4 ITCH â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19116316 34927784 24489825 28264927 22275353
GIT2 GIT1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12473661 28514442 16628223 33961781
ASAP2 ARF5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10022920 10749932
ARF4 GBF1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 17956946 22389062 23567335
EEA1 RAB5A â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11493665 16902405 15016378 11870209 10720461 34079125 11718716 9697774 10491193 14600265 20534488 15328530
EEA1 RAB5C â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12493736 25266290 34079125 25114243
ARRB2 ARRB1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 24069330 17353931 33961781 17620599
SNX1 VPS26B â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
SNX2 VPS26B â—¼   PHYSICAL_INTERACTION 902.0 0.9 STRING 36370105
CBLB SH3KBP1 â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
CHMP4A PDCD6IP â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
SNX1 VPS26A â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
SNX2 VPS26A â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
SNX2 VPS35 â—¼   PROTEIN_INTERACTION 0.92 0.92 HIPPIE 11102511 22863883 22939629 26344197
ACTR2 NCKIPSD â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
CHMP4B CHMP5 â—¼   PHYSICAL_INTERACTION 924.0 0.92 STRING 36370105
CBL SH3KBP1 â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
ARFGAP1 ARFGAP3 â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
ARFGAP1 ARFGAP2 â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
AP2B1 EPN1 â—¼   PROTEIN_INTERACTION 0.93 0.93 HIPPIE 34079125 22863883
PARD6G PRKCI â—¼   PHYSICAL_INTERACTION 929.0 0.93 STRING 36370105
AP2M1 TGOLN2 â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
AP2B1 LDLRAP1 â—¼   PHYSICAL_INTERACTION 933.0 0.93 STRING 36370105
CLTCL1 DNAJC6 â—¼   PHYSICAL_INTERACTION 936.0 0.93 STRING 36370105
CHMP1A CHMP2A â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
SH3KBP1 CBLB â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 6170278 12177062
SNX1 VPS29 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
SNX1 VPS35 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
CHMP4B CHMP6 â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
RUFY1 RAB4A â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 11172003 20534812 34079125 14617813
ACTR3B ARPC2 â—¼   PHYSICAL_INTERACTION 954.0 0.95 STRING 36370105
CBLB EGFR â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
EGFR CBL â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 16729043 5218694
CBL EGFR â—¼   COLOCALIZATION ✅ 0.96 0.96 mint 16914641 7033849 028274
AP2S1 AP2A1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 31353312 16189514 7593184 33961781 26344197
RAB5C RAB5A â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 17353931 26496610 33961781 34079125
SNX6 SNX2 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 32296183 21988832 22863883 33961781 11279102 22939629 26344197
ACTR3B ARPC1A â—¼   PHYSICAL_INTERACTION 959.0 0.96 STRING 36370105
CLTC DNAJC6 â—¼   PHYSICAL_INTERACTION 964.0 0.96 STRING 36370105
ACTR3B ARPC3 â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
SNX1 SNX6 â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
SNX2 SNX6 â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
ACTR2 ACTR3B â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
ACTR3B ARPC4 â—¼   PHYSICAL_INTERACTION 967.0 0.96 STRING 36370105
AP2A1 AP2M1 â—¼   PHYSICAL_INTERACTION 969.0 0.97 STRING 36370105
SH3KBP1 CBL â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 6170483 15090612
ARPC4 ARPC3 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 32296183 23148219 11162547 22863883 33961781 24981860 22939629 26344197
PARD3 PARD6A â—¼   PHYSICAL_INTERACTION 969.0 0.97 STRING 36370105
VPS35 VPS26A â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 24152121
VPS35 VPS29 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 24152121
PARD3 PARD6B â—¼   PHYSICAL_INTERACTION 970.0 0.97 STRING 36370105
CHMP4B PDCD6IP â—¼   PHYSICAL_INTERACTION 970.0 0.97 STRING 36370105
CHMP2A CHMP3 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
ARPC1A ARPC5L â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
AP2A1 AP2S1 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
CHMP3 CHMP4B â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
PARD6B PRKCI â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
SNX2 VPS35 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
SNX2 VPS29 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
PARD6A PRKCI â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
EEA1 RAB5A â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
VPS26B VPS29 â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
ARF1 CYTH2 â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
ARRB1 CLTC â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
ARPC2 ARPC4 â—¼   PROTEIN_INTERACTION 0.98 0.98 HIPPIE 11805826 11162547 22863883 33961781 24981860 22939629 26344197
CHMP2A CHMP4B â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
RAB11A RAB11FIP3 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
CBLC EGFR â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
CHMP1A IST1 â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
VPS26A VPS29 â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
RAB11A RAB11FIP2 â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
ARPC2 ARPC3 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 28514442 11805826 23148219 22863883 33961781 24981860 9230079 26186194 22939629 26344197
SNX6 SNX1 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 28514442 32296183 23524952 21988832 33961781 11279102 22939629 26344197
ACTR3 ARPC5L â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
AP2B1 AP2S1 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
AP2B1 AP2M1 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
ACTR3 ARPC1A â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
ACTR2 ARPC5L â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
AP2M1 AP2S1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
ARPC2 ARPC5L â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
ACTR2 ARPC1A â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
ARPC1A ARPC3 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
ARPC4 ARPC5L â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
ARPC1A ARPC2 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
ARPC1A ARPC4 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
ARPC3 ARPC5L â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PARD3 PRKCI â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
VPS26A VPS35 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
CBL EGFR â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ACTR2 ARPC4 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ACTR2 ARPC3 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ACTR2 ARPC2 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ACTR2 ACTR3 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ACTR2 ACTR3 â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ACTR2 ARPC4 â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ACTR2 ARPC3 â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ACTR2 ARPC2 â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
CLTCL1 AP2M1 â—¼   PHYSICAL_INTERACTION 16.0 1.0 Reactome 1847920 20448150 10559856 19713939 19776351 21883765 15916959 26403691 22863004 23891661 19809571 21445324 15339664 21613550 21779028 19296720
AP2M1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 23956138 31980649 24189400 19351721 20029029 24797263
HGS CBL â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 24828152 12686592 12551915 15828871 19109251
INSR CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 11997497 10635327 11994282 12522270 9525940 12604776 10592173 17570479 9102067 15951569 10829062 15212693 11239464
SH3KBP1 CBL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 74.0 1.0 Omnipath 20130058 20711168 12618476 11894095 16407834 16713569 11071869 19268472 25472714 17306257 22262777 15456872 11152963 10679202 15962011 25036637 15107835 22833562 11067845 11894096 12177062 17675467 21830225 12135478 24167568 16228008 12874286 17072306 15090612 14596919
CBL EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 188.0 1.0 Omnipath 34609770 16105874 18273061 22239438 24797263 20332299 17635922 23158001 17545148 8662998 12604776 9890970 23153581 17182860 25872741 12593795 23175185 10092522 15107835 22266821 22833562 24714105 17242169 25140053 20124286 19531499 9756944 10086340 22203672 19225046 16729043 15282549 20562913 22394513 20940296 23331499 7592693 19713535 10635327 19836242 15465819 15210722 25521828 23897813 10514377 12734385 18508924 11994282 20877636 33323455 22976291 23774213 23027125 15159412 18255265 16246327 28541302 16849543 23799367 16713569 10799548 8798643 19155296 9121472 17486068 21772844 16969069 15677445 15962011 23418353 12803489 32714745 14505571 27903975 19578043 26177020 11239464 18319245 11408594 10428778 12061819 17995934 17971399 27059931 26055326 15735736 23457600 7782294 22591401 29629558 11370743 7657591 21071413 28198003 18316398 19947936 9130710 18271526 15657067 31182136 16923119 17880946 32904620 15117950 14627991 15668240 15383614
CBL PDGFRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 9234717 10347229 18988627 17635922 10514377
DNM2 CLTC â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10480952 7650016 7592972 10593899 14731593 2121367 9497313 8939989
DNM2 CLTC â—¼   GTPASE_REACTION ✅ 7.0 1.0 Reactome 10480952 7650016 7592972 10593899 2121367 9497313 8939989
CAV1 EGFR â—¼   DOWN_REGULATES ✅ - 13.0 1.0 ACSN 11102446 17517963 18458534 19411448 20855962 21051947 21150282 21729786 22411312 22874531 23907124 25364523 26828520
CBLB EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 17145710 19531499 11375397 10086340 12577067 10542134 17635922 10514377
PDCD6IP EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 31980649 15456872 12771190 24658140 15557335 25402006
CBLC EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 10362357 22888118 17635922 10514377
EGFR PLD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 9837959 20647543 20176813
EGFR HGS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12953068 17016520
EGFR ARF4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12446727
EGFR PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 21220489 24655521 23542172 29140271 28157503 26725162 22238610 25825764 17115032 26719139 28102297 22692198 28666590 25073158 20670598 20587074 23593472 25675097
EGFR CAV1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 17145710 31980649 22411794 9374534 19446582 16799092 12388423 15657067 24658140 19625610 16407214 18789131 25402006 15951569 10781609 16332692
PCNA EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 18263614 11268218 16713569
EP300 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 21988832 23331499 9169454 12237408 10199400 11264182 7878020 8047140 12958365 19171760 11371641 16027720 17074756 17469772 21269274 15623506
HGS CHMP2A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 20708039 11333915 16867982 9733768
HGS SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 11094085
RHOA PLD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11102529 12593858 9565577 11311142
CYTH2 ARF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9417041 16189514 14565977
ARPC2 ARPC3 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ACTR3 ARPC3 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ARPC3 ARPC4 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ARPC2 ARPC3 â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ACTR3 ARPC3 â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ARPC3 ARPC4 â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
PDGFRB PDGFRA â—¼   PHYSICAL_INTERACTION 5.0 1.0 ACSN 15099563 17145802 17496910 18633355 24359404
PDGFRB PDGFRA â—¼   SHARES_COMPLEX 5.0 1.0 ACSN 15099563 17145802 17496910 18633355 24359404
PDGFRB PDGFRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 23331499 21071413 2161888 2542288 7523122 1847074 16189514 11331882 10417313
ACTR3 ARPC2 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ACTR3 ARPC4 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ACTR3 ARPC4 â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ACTR3 ARPC2 â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ARPC2 ARPC4 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ARPC2 ARPC4 â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
DAB2 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 16713569 11387212
SMURF1 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 10458166 23331499 15221015 20207742 15231748
ACVR1B SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23331499 9346908 11389842 9892009 18988627 14517293
NEDD4L SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 19917253 26555259 15496141 15231748
PLIN3 IGF2R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10908666 9590177
ASAP2 ARF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 10022920 11304556 10749932
ARFGAP1 ARF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 1010276 10102276 19020038 16189514 9733781
CYTH2 ARF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 14654833 17563369 8945478 16189514 10198630 9417041
ARF1 PLD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10801846 11373276 12519790
HRAS FGFR1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
HRAS FGFR4 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
SMURF1 PARD6A â—¼   PHYSICAL_INTERACTION 8.0 1.0 ACSN 14657501 14722617 14744429 15265520 15761148 16472676 21572392 22949611
SMURF1 PARD6A â—¼   PROTEIN_INTERACTION 8.0 1.0 ACSN 14657501 14722617 14744429 15265520 15761148 16472676 21572392 22949611
SMURF1 RHOA â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 14657501 14722617 14744429 15265520 15761148 16472676 21572392 22949611
PARD6A SMURF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 21262463 15761148 19114990
SMURF1 RHOA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 15761148 21572392 16472676 16622418 28658604 15710384 14744429 14657501 22949611
IL2RG IL2RA â—¼   PHYSICAL_INTERACTION 26.0 1.0 ACSN 10807786 10820393 10849428 12095053 15289500 15563472 16212621 16799562 17371980 1825141 18758473 19528259 19833085 20856220 21840487 22224781 23124025 23650441 24829413 26755705 2965306 6164929 7512720 7521688 8683106 9625766
IL2RG IL2RA â—¼   SHARES_COMPLEX 26.0 1.0 ACSN 10807786 10820393 10849428 12095053 15289500 15563472 16212621 16799562 17371980 1825141 18758473 19528259 19833085 20856220 21840487 22224781 23124025 23650441 24829413 26755705 2965306 6164929 7512720 7521688 8683106 9625766
IL2RA IL2RG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15933202 15265897 8568232 8260650
CLTCL1 AP2B1 â—¼   PHYSICAL_INTERACTION 16.0 1.0 Reactome 1847920 20448150 10559856 19713939 19776351 21883765 15916959 26403691 22863004 23891661 19809571 21445324 15339664 21613550 21779028 19296720
CLTCL1 AP2S1 â—¼   PHYSICAL_INTERACTION 16.0 1.0 Reactome 1847920 20448150 10559856 19713939 19776351 21883765 15916959 26403691 22863004 23891661 19809571 21445324 15339664 21613550 21779028 19296720
PARD6A RHOA â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 14657501 14722617 14744429 15265520 15761148 16472676 21572392 22949611
CXCR4 RHOA â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 15261139 15882617 17035340 20535745 20644254 21521526 22025564 23034983 23402812 23567181 24277834
INSR CAV1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9756945 10598578 12036959 17699617
CAV1 PDGFRA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 18988627 16189514 10066366
ITCH CXCR4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 28264927 19116316 24489825
GRK6 CXCR4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 30936203 25355818 20048153 24309376 19116316 28328745 24489825
GRK3 CXCR4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11668182 16189514
DNM2 SH3GL3 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 16732277 16339507 25748042 17088212 29559111 17088211 9808461
AP2A1 CLTCL1 â—¼   PHYSICAL_INTERACTION 16.0 1.0 Reactome 1847920 20448150 10559856 19713939 19776351 21883765 15916959 26403691 22863004 23891661 19809571 21445324 15339664 21613550 21779028 19296720
RAB8A RAB11A â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 20308558 22433857 22983554 12221131 23567335 21273506
ARF4 RAB11A â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 17007872 17628206 17030804 19153612 18685082 22983554 23567335
RAB11A ASAP1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 17007872 17628206 17030804 19153612 18685082 22983554 23567335
RAB4A RUFY1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20534812 11172003 14617813
RAB11FIP3 ARF4 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 17007872 17628206 17030804 19153612 18685082 22983554 23567335
ARF4 ASAP1 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 23945166 9819391 19153612 18685082 22983554 16431365 16038802 16136078 23567335
ARF4 GBF1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 22013193 20357002 17429068 18524849 16030262 16633337
RAB5A EEA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 15328530 17145710 20534488 14600265 11718716 10491193 11493665 11870209 16902405 15016378 10720461 9697774
RAB5C EEA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 25266290 12493736 25114243
RAB11FIP3 ASAP1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 17007872 17628206 17030804 19153612 18685082 22983554 23567335
RAB11FIP3 RAB8A â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 20308558 22433857 22983554 12221131 23567335 21273506
PRKCI PARD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17145710 14676191 22579248 27554858
VPS29 VPS35 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
VPS29 VPS35 â—¼   PROTEIN_INTERACTION 1.0 1.0 HIPPIE 28514442 32296183 25416956 24980502 11102511 29893854 24344282 22863883 25502805 24747528 17891154 33961781 22939629 26344197
RAB8A ASAP1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 20308558 22433857 22983554 12221131 23567335 21273506
ACVR2B ACVR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 23180781 8622651 16446785 12364468 18988627