Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
DVL2 APC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7890890 20224554
APC SCRIB â—¼   COLOCALIZATION 2.0 0.8 intact 16611247 6549797
DVL1 APC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20224554 10330181
BBC3 BAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22492984 17289999
SMAD3 BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11906909 16603637
STAT3 BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17089128 20422978
BAX GSK3B â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 0912742107 20080742
YWHAQ BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12426317 16713569
TP63 BBC3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21527555 24117128
CCT2 MAP3K3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
DVL2 CSNK1E â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
CSNK1E YWHAH â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7264069 19860830
CSNK1E CDH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20940130
SUMO3 EP300 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7941484 19680224
EP300 BIRC5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20660371 19102934
TP73 EP300 â—¼   ACETYLATION ✅ 2.0 0.8 intact 11804596 5215037
EP300 DDX17 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20663877
TP73 KAT2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14614455 21245298
MYC TGFBR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
MYC TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15466196 12080469
STAT3 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22943793 15810077
TCF7 SNAI2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20128911
SNAI2 SOX9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 21645238 19756381
TCF7L2 STAT3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18602747
STAT3 SOX2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20132009 18447642
STAT3 SOX6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21094641 24066135
PPP1CA STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19440292
STAT3 BIRC5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12393476
STAT3 MYOD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16713569 12947115
TP73 TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21933882 17725714
TP63 TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23071313 21933882
TTF1 TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10499522 21784970
TNF LTBR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8171323 24636534
TNF PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22078880 20651683
YAP1 TP63 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5213829 11278685
TP73 TP63 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19815500 0905867106
TP63 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22777354 23837456
MYOD1 TP73 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18513743 16007124
TP73 WNT4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16343436 20161747
TP73 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11309270 22842668
WNT1 PAX8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18495817
WNT1 SOX9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18495817
YWHAG YAP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
YWHAQ YAP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12535517 5216053
MED28 YAP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7033846 16964398
YAP1 SLC9A3R2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217948 16166090
LATS2 YAP1 â—¼   PHOSPHORYLATION ✅ - 0.8 0.8 Signor 22658639
TJP2 YAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20868367 23829894
FBXW11 YAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22017875 21900206
CTNNA1 YAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 23949920 23431053
YAP1 TEAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11358867 23431053
GSK3B YBX1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 16198352 5217974
PPP1CB NF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18071304
FZD7 WNT5A â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20457807 24865425
CTNNB1 FZD7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12095419 15473860
WNT8A FZD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 10097073
RUNX2 AXIN2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19585539 23300083
SMAD1 BMP7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20375015 17127702
TJP1 ACTB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219015 16944923
JUP BIRC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
ACTG1 MAP3K3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
CCND3 AREG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11469683 16713569
YWHAG ID2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ID1 ID2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9779825 19896442
HIF1A ID2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15252039 11955624
CTNNB1 ID2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11572874 12095419
SMAD4 MYOD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD7 MYOD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
CTNNB1 MYOD1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18948405 15031118
PPARG MYOD1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16838108 11477074
MYOD1 CCND3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10373569
SMAD3 MYOD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11711431
PAX8 SMAD4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
SMAD4 ID1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19079362 12296825
SMAD4 CCN2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19385047 11590167
SMAD4 BTRC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 14988407
CDH1 TGFBR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TGFBR2 SMAD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 21358634 9679059
TGFBR2 SMAD3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 21358634 9679059
BMPR1B SMAD7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12857866 12519765
SMAD7 BMPR1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12857866 12519765
SMAD7 BMP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12857866 12519765
SMAD7 BMPR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12857866 12519765
SMAD7 SOX5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD7 TGFB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10519551 19758997
SMAD7 CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15684397 1568439
SMAD7 TGFB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15855641 19385040
SMAD7 SERPINE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18762808 17438144
AXIN1 SMAD7 â—¼   COLOCALIZATION 2.0 0.8 intact 16601693 5218493
SMAD7 BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10564272 23331499
TGFB1 SMAD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 21358634 9679059
PPP2R1A SMAD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
TGFBR1 SMAD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18511908 6798777
SMAD2 RUNX2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15599395 9812998
SMAD2 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21836474 21926264
TGFBR1 SMAD2 â—¼   PHOSPHORYLATION ✅ + 0.8 0.8 Signor 10973958
WWTR1 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21084559 18568018
SMAD2 TCF7L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15292219
SMAD3 MED15 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12167862 5215637
SMAD3 PPP2R1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD3 GLI2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19797115
SMAD3 RUNX2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11331591 21612856
WWTR1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21084559 18568018
SMAD3 PAX8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 14623893
SMAD3 TCF7L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15292219
TGFBR1 DLG5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8426596 23624079
RUNX2 TGFBR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20093419 16806744
GSK3B AXIN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219694 17318191
WNT3A AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10428961 8666229
FZD5 AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10428961 8666229
FZD4 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 27096005 19388021
FZD2 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23151663 19388021
FZD3 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22944199 19388021
PPARG YWHAE â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19221220 20127524
CTNNB1 CDH1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12640114 5216233
CDH1 SCRIB â—¼   COLOCALIZATION 2.0 0.8 intact 21701506 8203421
WNT10B FZD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19008118 12055200
WNT6 FZD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12857724 8717036
HIF1A SUMO3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7941484 19680224
SCRIB MAP3K3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
SCRIB FZD3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 21983142 16687519
RUNX2 WWTR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12529404 16099986
TEAD3 WWTR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 19324876 19324877
CTNNB1 WWTR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8383887 22234184
WWTR1 TEAD4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
WWTR1 TEAD3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
WWTR1 LATS2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 21205866 18227151
WWTR1 TJP2 â—¼   COLOCALIZATION 2.0 0.8 intact 7994830 20850437
WWTR1 SLC9A3R2 â—¼   COLOCALIZATION 2.0 0.8 intact 5213315 11118213
WWTR1 TJP1 â—¼   COLOCALIZATION 2.0 0.8 intact 7994830 20850437
AMOT WWTR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 21205866 23431053
KLF5 SERPINE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16102021 10865841
TCF7L2 GLI2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19797115
GLI2 BMP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19103752 16880529
GLI2 BMP4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18710724 20934421
GLI2 WNT2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19360354
PRKCZ PARD6G â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17057644 5219258
SOX5 SMAD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD1 MED15 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12167862 5215637
SMAD1 CCN2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18668566 20522428
SMAD1 RUNX2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19664780 24692107
SMAD1 RUNX2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17215250 22298955
SOX9 RUNX2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0605170103 17142326
KLF5 SOX9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 23266329 24440658
SOX9 CCN2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 23631855 20571031
SOX9 RUNX2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19306868 20593410
MED28 DLG4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7033846 16964398
DLG4 DLG2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
MAP3K2 YWHAG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
FRMD6 YWHAG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
YWHAG TJP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
YWHAG MAP3K3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
YWHAE MAP3K3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
MAP3K2 YWHAE â—¼   COLOCALIZATION 2.0 0.8 intact 9452471 5221876
MOB1A LATS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21084559 19739119
MOB1B LATS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21084559 19739119
MOB1A LATS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21084559 19739119
MOB1B LATS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21084559 19739119
PPP2R2A PPP2R1B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8208439 17540176
PPP2R1B MAP3K3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
PPP2R1A MAP3K3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
PPP1CA CCND3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16331257
GSK3B CTNNB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219694 17318191
GSK3B APC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 10698523
CTNNB1 PARD3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17057644 5219258
CTNNB1 CTNNA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12640114 5216233
CTNNB1 BTRC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15473860 10882123
CTNNB1 CCN2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20571031 12200448
CTNNB1 SOX2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 24291232 24482235
CTNNB1 TCF7L1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11136974 11266540
DVL3 CSNK1D â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
CSNK1D APC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 11818547
CTNNA1 PARD3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17057644 5219258
PPP1CA MAP3K3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
PPP1CC MAP3K3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
DLG1 MAP3K3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
YWHAH MAP3K3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
YWHAQ MAP3K3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
WNK1 MAP3K3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14681216
BMPR1A BMPR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10712517
ID1 BMP4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20970407 21996749
TBX5 BMP4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20858598 17173667
WNT5B FZD8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 26849959 20093360
BMP8B BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 10504300
TCF7 LEF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 32448362 25921273
RUNX2 LEF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20890621 19650108
LEF1 RUNX2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16575901 16043491
WNK1 MAP3K2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14681216
TCF7L2 TCF7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15473860 10489374
WNT4 FZD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 14671310
WNT5A FZD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 19910923 19582886
WNT2 FZD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24032637
WNT5B FZD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16273260 15578921
WNT11 FZD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16273260 15578921
APC2 CTNNB1 â—¼   RELOCALIZATION ✅ - 0.8 0.8 Signor 10980707
DLG4 LLGL2 â—¼   PHYSICAL_INTERACTION 804.0 0.8 STRING 36370105
APC BTRC â—¼   PHYSICAL_INTERACTION 806.0 0.8 STRING 36370105
DDX17 EP300 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 17226766 19995069 33742100 20663877
SMAD1 DVL1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 12650946
GSK3B SMAD1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 25241761 18045539
AMOTL1 NF2 â—¼   PHYSICAL_INTERACTION 810.0 0.81 STRING 36370105
LATS2 SAV1 â—¼   PHYSICAL_INTERACTION 811.0 0.81 STRING 36370105
LATS1 YAP1 â—¼   PHOSPHORYLATION ✅ - 0.81 0.81 Signor 22658639
BIRC2 BTK â—¼   PHYSICAL_INTERACTION 816.0 0.81 STRING 36370105
DVL1 DVL2 â—¼   PHYSICAL_INTERACTION 817.0 0.81 STRING 36370105
DVL1 APC â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 20224554 11425858
ACTB EP300 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33742100 21988832
SMAD2 KAT2B â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22995475 15009097 11058129 34576109
SMAD3 KAT2B â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22995475 15009097 11058129 15994459
MYC DDX17 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21150319 29467282
KLF5 YAP1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 35140242 22632819
YAP1 GSK3B â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 24976009 29789528
AXIN1 AXIN2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22682247 20128690
DVL1 SMAD4 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 12650946
SMAD7 LEF1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 15750622 15684397
SMAD2 KLF5 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 19419955 18729074
SMAD1 LEF1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 10890911 15750622
YWHAG MAP3K2 â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 5217174 15324660
SAV1 AMOT â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 30266805 24255178
PARD3 AMOT â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 16678097
TEAD2 TEAD1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
SOX2 TEAD1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 35140242 21532573
WNT7A WNT5A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
WNT7A WNT7B â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
WNT16 WNT5A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
WNT5A WNT5B â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
WNT16 WNT11 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
STK3 MOB1B â—¼   PHOSPHORYLATION ✅ + 0.82 0.82 Signor 21808241
WWTR1 TEAD2 â—¼   PHYSICAL_INTERACTION ✅ + 0.82 0.82 Signor 23431053
DLG4 FZD7 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 12067714
MED15 SMAD2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 12167862 27703004
AXIN1 DVL3 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 22682247 12805222 20128690
WWTR1 AMOT â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 20972459 33961781 26186194
YWHAG FRMD6 â—¼   PHYSICAL_INTERACTION ✅ 0.83 0.83 mint 5217174 15324660
MOB1B MOB1A â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 24366813 33961781
LATS1 PARD3 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 34079125 26116754 24255178
TEAD4 DLG3 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
TEAD4 TEAD1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
TEAD4 TEAD2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
MED28 MED15 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 15175163 33961781 20133760 24981860
BMPR2 BMP6 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 11401330 10504300
WNT4 WNT5A â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
WNT4 WNT7B â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
WNT3A WNT3 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
BTRC GSK3B â—¼   PHYSICAL_INTERACTION 832.0 0.83 STRING 36370105
AXIN2 CTNNB1 â—¼   DOWN_REGULATES ✅ - 0.83 0.83 Signor 11940574
AXIN1 DVL3 â—¼   PHYSICAL_INTERACTION 834.0 0.83 STRING 36370105
CTNNB1 SMAD3 â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
RASSF6 STK3 â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
CTNNB1 PPARG â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
MYC ACTB â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 11839798 29467282
MYC HIF1A â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 28628118 15071503 28205554
DVL1 SMAD7 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 12650946
DVL1 SMAD3 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 12650946
SMAD1 SMAD3 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 9111321 15761153 18729074
TGFB2 TGFB1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 27684187 11483955 33961781 11157754
RUNX2 SMAD1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 10531362 10962029 17215250 20851880
LATS2 AMOT â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 24225952 24101513 24106267 24255178 30266805
FZD8 WNT3 â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
SOX5 SOX6 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 28514442 9755172 33961781
HIF1A STAT3 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
HIF1A KAT2B â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
LLGL2 PRKCZ â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
MOB1B STK3 â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
GSK3B CTNNB1 â—¼   PHOSPHORYLATION ✅ - 0.84 0.84 Signor 16293724
AXIN2 APC â—¼   PHYSICAL_INTERACTION ✅ + 0.84 0.84 Signor 10911903
AMOT NF2 â—¼   PHYSICAL_INTERACTION 845.0 0.84 STRING 36370105
KAT2B SMAD3 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
AXIN1 APC â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 7025676 19131971
PAX8 EP300 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 10924503 35140242
EP300 SOX9 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 15623506 35140242 12732631 19828133
EP300 SMAD1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 10205054 20851880 22365546 16613856 10673036
STAT3 HIF1A â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 15735682 18985005 23604114 23991099
FZD8 WNT1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 15454084 11448771
PRKCZ PRKCI â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 24375676
LATS2 LATS1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 33961781 24255178 34079125 32707033 21233212
TP53BP2 PPP1CC â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 21998301 270751 8217559
NF2 AMOT â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 24981860
EP300 KLF5 â—¼   PHYSICAL_INTERACTION 850.0 0.85 STRING 36370105
PPP2R1B PPP2R2B â—¼   PHYSICAL_INTERACTION 850.0 0.85 STRING 36370105
RUNX2 SMAD1 â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
TP53BP2 TP73 â—¼   PHYSICAL_INTERACTION 853.0 0.85 STRING 36370105
CTNNB1 TCF7 â—¼   PHYSICAL_INTERACTION 858.0 0.85 STRING 36370105
DVL2 APC â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 20224554 26496610
SMAD4 EP300 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 9679056 25514493 18215124 9843571 14612423 10887155 22033265
EP300 STAT3 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 10205054 15653507 16713569 33531691 26504087 18782771 30110629 11923478 15735682 15649887 33742100 22116549
EP300 SMAD3 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 9679056 15824515 15688032 16109717 15345715 20564330 9843571 15133024 10497242 17469184 15623506 10575014 15588252 18055455 16876108 21567395 11134049 12743039 11058129
KAT2B HIF1A â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 22908229 21148070 20620956 16543236
YAP1 YWHAG â—¼   PHYSICAL_INTERACTION ✅ 0.86 0.86 mint 5217174 15324660
YAP1 AXIN1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 24976009 29789528
ID2 MYOD1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 21209940 9242638
SMAD7 AXIN1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16601693 18593713
WWTR1 LATS1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 20412773 27847303 29787761 26116754 22078877 21555462
TP53BP2 PPP1CA â—¼   PHYSICAL_INTERACTION ✅ 0.86 0.86 mint 5217094 15231748
YAP1 YWHAQ â—¼   PHYSICAL_INTERACTION 864.0 0.86 STRING 36370105
EP300 RUNX2 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
C1orf74 WWTR1 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HuRI 32296183
MYC EP300 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 15616592 16287840 32140074 16126174 17157259 12776737
KAT2B MYOD1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 20364308 9659901 27453350 17964260 10944526 10619020 12887892 17468105
TEAD3 WWTR1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 16189514 33961781 26186194
TEAD4 WWTR1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 25670202 16189514 32296183 20972459 26116754 30472188 33961781 26186194
WWTR1 WBP2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 27578003 20972459
WWTR1 TEAD1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 32296183 25796446 33961781 26186194
STK3 MOB1A â—¼   PHOSPHORYLATION ✅ + 0.87 0.87 Signor 23431053
TCP11L1 WWTR1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HuRI 32296183
LATS2 MOB1B â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
EP300 STAT3 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
APC CTNNA1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
BIRC2 TNF â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
AMOTL2 YAP1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
BTRC FBXW11 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
EP300 TP73 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
SMAD4 SMAD7 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
BTRC WWTR1 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
AXIN1 BTRC â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
PARD3 PARD6G â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
RASSF4 STK3 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
TEAD1 TEAD4 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
EP300 PPARG â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
BTRC SMAD4 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
TJP1 TJP2 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
APC DLG1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 30126976 23185543
EP300 SMAD2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 11371641 21988832 10199400 12237408 11264182 15623506
MYOD1 STAT3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 12947115 16713569
YAP1 LATS1 â—¼   PHYSICAL_INTERACTION ✅ 0.88 0.88 mint 25283809
YAP1 CTNNB1 â—¼   PHYSICAL_INTERACTION ✅ 0.88 0.88 mint 22234184 8383887
DDX17 YAP1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 27684187 31501420 24581491
LATS2 YAP1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 18640976 21041410 25670202 34404733 30865227 33368671 18413746 18565851 26578655 28205554 28754671 25751139 19797269 30472188 29183995 28628118 21832154 25796446 22863277 26598551 21041411 30266805 19919647
AXIN2 GSK3B â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 12183362 10966653 33961781 23602568 32707033 23455922 29568061 30824926
BMPR2 BMP7 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 7644468 7791754
ID1 MYOD1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 8380166 9528857 15029197 18674781 20195544 12145280 9242638
SMAD2 LEF1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10890911 15750622
SMAD2 SMAD1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 9111321 28628118 18729074 28205554
GSK3B SMAD3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 21310903 18172167
SMAD3 LEF1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10890911 15750622
YWHAE YWHAG â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
YWHAE YWHAH â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
LATS2 MOB1A â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 23886938 29183995 19739119 20624913 33961781 24255178 31941533 26898830
LATS2 MOB1B â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 19739119 33961781 24255178 32707033 19919647
LATS1 MOB1A â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16061636 16674920 33141042 19739119 20624913 24255178 31941533
MOB1B LATS1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 16674920 19739119 33961781 24255178 34079125 24366813 18328708
AMOT LATS1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 30266805 32292505 24101513 24255178 34079125 24366813
PPP2R2A PPP2R2D â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
CTNNB1 TCF7L1 â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
BMP4 BMPR2 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
PPP1CA PPP1CB â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
ID1 MYOD1 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
EP300 MYOD1 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
TP53BP2 YAP1 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
CTNNB1 JUP â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
YWHAG YWHAH â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
PPP2R1B PPP2R2D â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
EP300 SMAD4 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
EP300 KAT2B â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
AMOT YAP1 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
BMP2 BMPR1B â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
PPP1CB PPP1CC â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
BTRC YAP1 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
CDH1 CTNNA1 â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
BTRC CTNNB1 â—¼   UBIQUITINATION ✅ - 0.88 0.88 Signor 10228155
LLGL2 PARD6G â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
AJUBA LATS2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 20303269 33961781 16413547
KAT2B EP300 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 8684459 12888487 9267036 12419806 21413932 22384255 20870727 33051058
EP300 KLF5 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 14612398 19419955 15668237 35140242 16102021
KAT2B MYOD1 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
MYC GSK3B â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16247449 11877389 14563837 20713710 19131971 21150319 31638140 8247524 29467282 33541412
CTNNB1 YAP1 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
AMOT YAP1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 30266805 23564455 24976009 24225952 25751139 31501420 32292505 29891922 30472188 24106267 24255178 24101513 32755583 24366813 19615732 22385262
SMAD1 YAP1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 19914168 21685363
YAP1 TEAD3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 27684187 25751139 25796446 26933062 35140242 24255178 24366813 11358867
TGFBR2 TGFB1 â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 8044119 21054789
HIF1A SMAD3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 12228247 28471448 11486006 14741200
SMAD3 RUNX2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10531362 10962029 21986102
DVL1 DVL2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24643799 28514442 20224554 33961781 26186194 31340145
DVL2 DVL3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24643799 31340145 33961781 28514442
TEAD4 WWTR1 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
TEAD2 WWTR1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 32296183 33961781 25609649
SAV1 LATS2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 25670202 34404733 25692647 24255178 30266805
STK3 MOB1A â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 18362890 31941533 24255178 23972470
STK3 MOB1B â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24255178 32296183 19919647
BMPR2 BMP4 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28126904 12045205 7673243 7644468 8702914
TP73 YAP1 â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
TEAD1 WWTR1 â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
CTNNB1 FBXW11 â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
SMAD3 TGFBR1 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
LATS1 WWTR1 â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
AXIN1 APC â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16199882 22682247 10228155 29045831 18786926 20128690 19131971 26496610 10811618 9734785 29713058 23277359 17510365
AXIN2 APC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10966653 10911903 9554852
SMAD4 BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15886208 16603637 18620728
BBC3 BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15574335
CSNK1E WWTR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 24715453
EP300 MYOD1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 20364308 12665587 20037778 17964260 35140242 10944526 9862959 9001254 8621548
EP300 PPARG â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11500849 17468099 10944516 14701856 11287611 19596656 32603375 11877444 12040021 10075656 30595551 22787115 12479814
EP300 RUNX2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20851880 22298955 12697832
MYC KAT2B â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15572685 35140242 12660246
SMAD2 MYC â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11804592 28628118 28205554
SMAD1 MYC â—¼   DOWN_REGULATES ✅ - 3.0 0.9 ACSN 15576399 22290435 22761862
MYC ACTG1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC SLC9A3R2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC YBX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12080043 18414489
MYC TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC AXIN2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19149881 24299953
MYC WNT10B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12747840
MYC GSK3B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC BMP4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC SMAD7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
AXIN1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19131971 20399964
PPP2CB PRKCD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11959144
PRKCD CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 25639486
PRKCD CDH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 27203386
TCF7L2 SNAI2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20128911 19443654
LEF1 SNAI2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20128911 16179074
STAT3 CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24287565 12147685
STAT3 CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20830236
PPARG TNF â—¼   DOWN_REGULATES ✅ - 3.0 0.9 ACSN 10432118 17681149 23390297
TP73 TP63 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16413471 21436470 18026135
TP63 CCND3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19861536
TP73 TP63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11238924 19815500 10373484
TP63 YAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11278685 35044719
TP73 CCND3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19861536
YAP1 BTRC â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
YAP1 LATS1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 18640976 27325643 32292505 27684187 27886176 21383157 18413746 33141042 26933062 24366813 31619268 28754671 30461308 27847303 25751139 29891922 17889669 30472188 28416659 25283809 24107629 22641346 18158288 25796446 22863277 20841485 24255178 21041411 34079125 30266805
YAP1 TEAD1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 30417565 35140242 24581491 26258633 27886176 11358867 26933062 31619268 31496812 25751139 29891922 30640473 24882516 25796446 22863277 25751140 32220262 24255178
YAP1 TEAD2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 32296183 28628118 25751139 20368466 28205554 35140242 33961781 25973055 26578655 11358867
YAP1 SMAD7 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 25283809 22921829 12118366
YAP1 RUNX2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31496812 25751140 32220262 27684187 10228168
YAP1 LATS2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 17974916 21832154 21205866
YAP1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23607968 22234184 23245941
YAP1 RUNX2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 14765127 22153608 10228168
YBX1 SMAD3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12917425 12446674 16278212
YBX1 SMAD4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12917425 12446674 16278212
WNT7A FZD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19497282 22944199 23290138
FZD7 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14636582 22179044 19388021
PPP2CB AXIN2 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 intact 1203359 10698523 8285077
HIF1A ITGB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20517715 15235127
SMAD2 SMAD4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9111321 25514493 11927552 28443643 21988832 20211142 15467747 12732634 25609649 15922743 12419246 9288972 21454478 19139564 24157709 18729074 22442258 17283070 16916642 15350224 17591701 11274206 15761153 31591477 26555259 9892009 9311995 10085121 9389648 10781087 12167862 10878024 18783722 27703004 18511908 28468752 19135894 10531362 12794086 15231748 21297662 12621041 19917253 11027280 24584437 16751102 31932471 10199400 21532621 12808092 33961781 11264182 11102446 11114293 12543979 23788427 15817471
SMAD1 SMAD4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9111321 17183365 16189514 32296183 31467278 12167862 14701756 12874272 28468752 15761153 24412244 10531362 15231748 11700304 11779505 26555259 9436979 21454478
SMAD3 SMAD4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9111321 16189514 25514493 11927552 28443643 21988832 20211142 15084259 12732634 19768112 15467747 20142324 25609649 15922743 12917407 12419246 20564330 24382352 19139564 32296183 24157709 18729074 22442258 10092624 17283070 15350224 17591701 15761153 31591477 10995777 26555259 9892009 9311995 15588252 12167862 10878024 25910212 27703004 33990575 28115363 18055455 22310290 19135894 10531362 12794086 15231748 21297662 22045334 19917253 24584437 27107012 29892012 29997244 21532621 27845895 21597466 25502805 11114293 12543979 23788427
SMAD7 SMAD4 â—¼   DOWN_REGULATES ✅ - 3.0 0.9 ACSN 11279127 15265520 23784029
SMAD4 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 22775504 17452626 24625091
FBXW11 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 14988407
TGFBR2 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8774881 15104092
AXIN1 SMAD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16601693
SMAD7 PPP1CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 16571110
SMAD7 BMPR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10564272 23331499 15761153
SMAD2 SMAD3 â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
SMAD2 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 27974707 11456453 16284942
SMAD2 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18729074 9111321
SMAD3 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 24424784 19597490 21798735
SMAD3 CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16055503 24416423
FBXW11 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 11359933
SMAD3 SOX9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15623506
PPP1CC TGFBR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 14718519
AXIN1 DVL2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 10829020 29659741 23892894 21245303
AXIN1 GSK3B â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 25241761 17601533 21988832 10228155 24976009 30181396 20128690 12511557 17318191 16293724 23455922 28546513 17318175 19303846 18632848 19131971 16890161 26496610 23892894 23602568 22613765 18593713 29568061 21242974 22682247 19759537 11738041 22270359 24451375 9734785 32707033 21502811 17510365 10481074 16199882 26912724 23959799 29045831 22509369 29789528 19202075 12584189
APC2 AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 9601641 10980707
DVL1 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10428961 16914735 20837657
TCF7L2 BIRC5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12885482 20331626
TCF7 BIRC5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11517919 16288908 17005722
SMAD1 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23071089 12589053 16580992
HIF1A PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18461556 19490906 11879638
PPARG CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22472882 20234816 21159608
LEF1 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 22933707 17452626 8892228
WNT2 FZD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24032637
TEAD4 HIF1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19236848 24213609 21540178
HIF1A IGFBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9707622 10102273 18056423
CSNK1D WWTR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 24715453
PRKCI LLGL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12725730
SAV1 STK3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 32707033 32296183 21988832 15688006 20920251 20562859 16930133 33961781 24255178 26186194 24981860 17379520 23455922 24366813
RASSF4 STK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20920251 32296183 25416956
NF2 LATS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 26045165 24012335
NF2 LATS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 26045165 24012335
PPP2R1A PPP2CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15936019 16039140
GSK3B FZD5 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CSNK1D GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21316585 23331499 11818547
CTNNB1 TCF7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15473860 17724465 10489374
CTNNB1 BMP4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10601040 12782598 15907834
CTNNB1 RUNX2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16575901 16043491 24692107
DVL3 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10644691 10806215
CSNK1D LEF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15327769 15747065
PPP1CA PPP1CC â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
BMPR2 BMP2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 10880444 10712517 25938661 7791754
TBX5 BMP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23632743 24866243 10814523
WNT8A FZD8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 28733458 10097073
TCF7 LEF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15473860 17335794 11326276
TCF7 RUNX2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16575901 16043491 24692107
WNT9B FZD5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 30978219 25892522 28733458
WNT3A FZD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21078818 18212053 10601008
WNT10B FZD5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 11092808 12055200
SMAD2 TGFBR1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
PPP1CA TP53BP2 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
PPP1CC TP53BP2 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
APC JUP â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
ACTB ACTG1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HuRI 32296183
APC GSK3B â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
CTNNA3 CTNNB1 â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
TEAD3 YAP1 â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
PPP2CB PPP2R2B â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
CTNNA1 JUP â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
WBP2 YAP1 â—¼   PHYSICAL_INTERACTION 916.0 0.91 STRING 36370105
PPP2R1A PPP2CB â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 5217765 15936019
DLG1 DLG3 â—¼   PROTEIN_INTERACTION 0.92 0.92 HIPPIE 33961781 12351654 26496610
BMP4 BMPR1A â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
AXIN2 GSK3B â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
DLG2 DLG4 â—¼   PROTEIN_INTERACTION 0.93 0.93 HIPPIE 9182804 21653829
CTNNB1 BTRC â—¼   PHYSICAL_INTERACTION ✅ 0.93 0.93 mint 5218183 16376880
PARD6G PRKCI â—¼   PHYSICAL_INTERACTION 929.0 0.93 STRING 36370105
CTNNB1 EP300 â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
LATS2 STK3 â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
RASSF2 STK3 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
RASSF1 STK3 â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
CTNNB1 AXIN1 â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 5219694 17318191
PARD6B PRKCZ â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
PARD6G PRKCZ â—¼   PHYSICAL_INTERACTION 942.0 0.94 STRING 36370105
LATS2 MOB1A â—¼   PHYSICAL_INTERACTION 942.0 0.94 STRING 36370105
APC2 CTNNB1 â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
PPP2R1A PPP2R2B â—¼   PHYSICAL_INTERACTION 944.0 0.94 STRING 36370105
EP300 SMAD3 â—¼   PHYSICAL_INTERACTION 945.0 0.94 STRING 36370105
ACTG1 ACTB â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 8153045 21516116
SMAD4 SMAD1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 17183365 5219486
DVL1 DVL3 â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 32296183 10330181
DLG4 DLG3 â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 10026200 28973854
STK3 SAV1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 24981860
STK3 RASSF2 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 24981860
PPP2R2A PPP2R1A â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 17245430 5219546
LLGL2 PARD6B â—¼   PHYSICAL_INTERACTION 954.0 0.95 STRING 36370105
LATS1 STK3 â—¼   PHYSICAL_INTERACTION 954.0 0.95 STRING 36370105
PPP2CB PPP2R2D â—¼   PHYSICAL_INTERACTION 955.0 0.95 STRING 36370105
LATS2 NF2 â—¼   PHYSICAL_INTERACTION 958.0 0.95 STRING 36370105
CTNNB1 APC â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 36950384
HIF1A EP300 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 17382325 5219810
SMAD7 YAP1 â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
SMAD1 SMAD4 â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
PPP2CB PPP2R1B â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
PPP2R1B PPP2R2A â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
TEAD2 YAP1 â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
MOB1A STK3 â—¼   PHYSICAL_INTERACTION 967.0 0.96 STRING 36370105
APC GSK3B â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 11166179 29045831 21118991 8638126 11251183 23602568 29568061
HIF1A EP300 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 15280364 19589782 16543236 11823643 22807441 19666581 16189267 18047470 15342390 12042299 19680224 22735262 23448368 26135796 23618863 14691445 19696166 11959990 27320910 16847340 24821806 22789427 17906695 8917528 20620956 20000859 15261140 16081065 12778114 22219185 15154850 25192544 22075993 19071119 22908229 19940151 21187066 24421387 23880760 11940656 23966271 26826385 26944191 12588875 23746844 11063749 27808477 19074848 20603618 15155277 18268343 20829524 21148070 12914934 17502379 22684029 17382325 26751287
YAP1 TEAD4 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 24525233 25751139 25796446 25751140 26592798 33571521 30472188 33961781 26186194 31559693 29091762 11358867 32537835
YAP1 WBP2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 27578003 7644498 27684187 25751139 25283809 26933062 30472188 24255178 24366813
AXIN2 CTNNB1 â—¼   PHYSICAL_INTERACTION 969.0 0.97 STRING 36370105
CTNNB1 GSK3B â—¼   PHYSICAL_INTERACTION 969.0 0.97 STRING 36370105
TCF7L2 CTNNB1 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 11713475 5214798
BMPR1A BMP2 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 19804412 7261592
PARD3 PARD6B â—¼   PHYSICAL_INTERACTION 970.0 0.97 STRING 36370105
LLGL2 PRKCI â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
PARD6B PRKCI â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
CDH1 JUP â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
CTNNB1 LEF1 â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
TGFBR1 TGFBR2 â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
SMAD1 YAP1 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
LATS1 MOB1A â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
LATS1 MOB1B â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
SAV1 STK3 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
LATS1 YAP1 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
AXIN1 DVL2 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
BMP2 BMPR1A â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
TEAD4 YAP1 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
PPP2R1A PPP2R1B â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
CCT2 PPP2CB â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
TEAD1 YAP1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
LATS2 YAP1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CTNNA1 CTNNB1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
AXIN1 CTNNB1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
PPP2R1A PPP2R2D â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PPP2R1A PPP2R2A â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PARD3 PRKCI â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PPP2CB PPP2R2A â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CTNNB1 TCF7L2 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
EP300 HIF1A â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
AXIN1 GSK3B â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
PPP2CB PPP2R1A â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
BTRC CTNNB1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
APC AXIN1 â—¼   PHYSICAL_INTERACTION 26.0 1.0 ACSN 10421629 10581160 11487578 11955436 11967263 12051714 12554650 15001769 15327768 16039586 16288291 16940750 17143292 17318175 17936032 19619488 19751508 20006983 20705860 22270359 23343194 24023259 25730849 7542250 8638126 8666229
APC CTNNB1 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
APC AXIN1 â—¼   PROTEIN_INTERACTION 26.0 1.0 ACSN 10421629 10581160 11487578 11955436 11967263 12051714 12554650 15001769 15327768 16039586 16288291 16940750 17143292 17318175 17936032 19619488 19751508 20006983 20705860 22270359 23343194 24023259 25730849 7542250 8638126 8666229
MYC APC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22911891 12695333
CSNK1E APC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 17145710 25241761 11425858 17570479 24722208 15327768 11487578 17218255
GSK3B APC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 16944320 11166179 16799642 11967263 14663202 8524413 12554650 8638126 17910481 15327768 10581160 11487578 17318175 15465828 10228155 15020233 10421629 10698523 9832503
CSNK1D APC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17910481 15327769 15747065 11487578
AXIN1 APC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 16199882 20128690 19131971 11297546 9554852 22682247 10228155 26496610 23277359 10811618 9734785
APC CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 60.0 1.0 Omnipath 17145710 10545404 11166179 8259519 7890674 22083140 27902311 8638126 16212417 16798748 19061640 9286858 15327769 9482734 11533658 22056988 19576224 15327768 17318191 26496610 12628243 15355978 9065403 11712088 25241761 26910375 22682247 9065401 12000790 11707392 20219694 9707618 23840886 15525529 11251183 8628279 19631635 11972058 21664290
BAK1 IGFBP1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 ACSN 18056423 22039431 23430059 23850759
BAK1 IGFBP1 â—¼   PROTEIN_INTERACTION 4.0 1.0 ACSN 18056423 22039431 23430059 23850759
BAK1 BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15901672 11571294 16189514 16439990
PRKCZ BAX â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 10873802 10934475 10954424 14766748 15642728 17525161 20505164
TP73 BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 18034190 17346710 18421303 21245298 10559267 18418051 18644986 17521288 19067706 11748232
HIF1A BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18366759 17558861 15706354 24349374
MYC BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8845569 11103792 12695333
PRKCZ BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 16679323 14766748 15642728 17525161
GSK3B BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 29379583 27762303 15525785 20976235 26287183 17911107 16709574
MYC BBC3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12695333 12384701 19815507 20145032 21835778
TP73 BBC3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15650240 19421143 18565851 15865927 17700533 18579560
TP73 BBC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11463391 19788416 11463392 14634023 14684737
DVL1 CSNK1E â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 Reactome 12556519 21285348 11818547 11425858 10535959 16965538 10517632
DVL2 CSNK1E â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 Reactome 12556519 21285348 11818547 11425858 10535959 16965538 10517632
CSNK1E DVL3 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 Reactome 12556519 21285348 11818547 11425858 10535959 16965538 10517632
CSNK1E CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 46.0 1.0 Omnipath 9312064 7641885 15265686 19718039 21602792 14966280 210606194 8655584 19705439 11818547 19029934 20093472 17430994 21606194 17884187 11955436 9482734 14747478 17570479 12176352 22017973 22433869 17143292 20006983 19072724 14704854 16965538 16443747 22007144 12000790 12114015 16547521 10488109 19020754 20940130 12417018 21640127 21087212 17127310 21796133 10023673
CSNK1E YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17081983 9360956 16045749 17570479 98030561
CSNK1E AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 21988832 10535959 22682247 11884395 26496610 11487578 12000790
CSNK1E DVL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 32888647 31515488 22609948 16189514 16713569 10517632
CSNK1E YAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 24715453 23431053
CSNK1E DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 23331499 11425858 20006983 14966280 20215527 16965538 21285348 11487578 11818547
CSNK1E GLI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 21233202 7641885 16611981 21536646 19797085 18455992 16371461
KAT2B EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8684459 14500836 9267036 17496784 20870727
PRKCD EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 11020388 17434128 12379484 15006641 18053091 15212693 12590608
EP300 TP63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15965232
EP300 MYOD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10944526 9001254
EP300 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 21988832 23331499 9169454 12237408 10199400 11264182 7878020 8047140 12958365 19171760 11371641 16027720 17074756 17469772 21269274 15623506
EP300 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 18782771 15509516 8756628 10205054 7530500 15653507 15735682 19506034 16285960 16713569 11322950 7499365 15649887 9590694
EP300 TP73 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 11804596 19407812 15175157 19788416 12660246 19218448 10648616 15454570 16998810 25675294 15893728 18663001
EP300 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 9843571 19419955 22033265 9679056 21269274
EP300 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12419246 14500836 10673036 22298955
EP300 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 75.0 1.0 Omnipath 24821806 12573436 17145710 16847340 12588875 19589782 11940656 25192544 11959990 18519678 23448368 22219185 11823643 12042299 15342390 23746844 19071119 19680224 27808477 15154850 19696166 8917528 17906695 18268343 22735262 21148070 15261140 19940151 23880760 22807441 35430356 14691445 12914934 20000859 12778114 26751287 16081065 22789427 16543236 24421387 17382325 17502379 22684029 21187066 19074848 23618863 23966271 20603618
EP300 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 9843571 11134049 12743039 15133024 15824515 15623506 16876108 21567395 16109717 17074756 20564330 10497242 15588252 17469184 15345715 11058129 10575014 16862174
EP300 CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17306568 17666529 23343194 21285352 15576399 21151179 22761862 22290435 16039586 19619488 19623618 17143292
EP300 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 17145710 22290435 19623618 11804596 23343194 22761862 16039586 12776737 17157259 17143292 12660246 15576399 21151179 15522869 17306568 19407812 17666529 21285352 19619488
EP300 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 11050151 18987336 15806138 15060161 17410209
EP300 SMAD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 23331499 12408818 10887155 15831498 21269274
KAT2B MYOD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17145710 9659901 10944526 10619020
KAT2B SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 34576109 17074756 11058129
KAT2B TP73 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11804596 19407812 19788416 12660246 14614455 18663001
KAT2B SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11058129 15994459
MYC AXIN1 â—¼   PHYSICAL_INTERACTION 22.0 1.0 ACSN 11274345 11283614 16713974 16940750 17558397 17873522 19131971 19366350 19751508 19836308 20027199 20237412 20551172 20581311 20713526 21406394 2191300 22067385 22270359 23732914 25002027 26885856
MYC AXIN1 â—¼   SHARES_COMPLEX 22.0 1.0 ACSN 11274345 11283614 16713974 16940750 17558397 17873522 19131971 19366350 19751508 19836308 20027199 20237412 20551172 20581311 20713526 21406394 2191300 22067385 22270359 23732914 25002027 26885856
STAT3 MYC â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10347215 11875494 12193690 12223527 12907458 14607900 14670306 15218058 15356132 15465827 15573129 16418395 17404308 18776941 19380816 20093776 20237412 20406969 20435894 20580461 20581311 21372296 21765015 21840487 22461508 23124025 23390297 23454751 23953057 24857661 27216177 28186502 7543512
MYC PPARG â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 10432118 11274345 11283614 11875494 16327802 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21093321 21372296 21406394 21765015 2191300 22067385 22461508 23124025 23390297 25002027
MYC HIF1A â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 10432118 11274345 11283614 11875494 16327802 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21093321 21372296 21406394 21765015 2191300 22067385 22461508 23124025 23390297 25002027
MYC TGFB1 â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 10432118 11274345 11283614 11875494 16327802 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21093321 21372296 21406394 21765015 2191300 22067385 22461508 23124025 23390297 25002027
TCF7L2 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 12095419 19561604 19895682 15579438 26947016 16204248 12799378 12907606 17360646 9727977 21533051 20133699 15576399 19784072 24447505 12591729 20818421 18852287 11973610
STAT3 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 19289167 17204573 18184402 22317895 20067773 15184887 15469392 10464281 9325164 20654581 21573184 17959148 22349830 9874564 20581311 19259613
SMAD4 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11689553 17132729
HIF1A MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 20404562 23059786 19845622 18616527 15780936 21303984
PPARG MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11973610 17462534 16405739 19075513
CTNNB1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 21533051 19778454 16510874 12095419 17360646 18852287 15576399 19561604 20300972 19662654 15579438 17724465 9727977 24447505 18679417 12907606
SMAD3 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 15930298 20516082 14993291 17132729 16205635 25238097 11689553 17114344
LEF1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19620402 18202148 17132729 19653274
MYC CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9632747 19176757 23364919 10523846
MYC CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 7526316 11511535 10508165 9339900 15988028 20857481 11060032 14519204 14660677 10956386 21790895 11264343
MYC WNT2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19609274 22710352 17485441 20945354 19149881
MYC ID2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12447693 12695333 12824180 18437010 18483244 12545167
MYC MYOD1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 1850105 7970710 19723804 12101422
MYC BIRC5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17170079 19287963 20508797 19602047
MYC TGFB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9196027 12695333
MYC SERPINE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12695333 18414489
TCF7 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17306568 17666529 23343194 21285352 15576399 21151179 22761862 22290435 16039586 19619488 19623618 17143292
PPP2CB MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 19131971 10026142 10995457 18042541 18559511 16987807 16680151 15048125
TCF7L1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17306568 17666529 23343194 21285352 15576399 21151179 22761862 22290435 16039586 19619488 19623618 17143292
GSK3B MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 73.0 1.0 Omnipath 17081983 18463697 21646472 30037819 26751215 25647305 2663470 20080742 19797085 30003124 16855632 12040186 18679417 11018017 23331499 29229669 16611981 21071413 24265759 20068231 10671551 16039586 17570479 16023596 29258530 12615961 18669648 21113395 22461507 19131971 8247524 16247449 20604938 19575820 15150404 22481935 23668310 19651622 17444818 23964270 20537194 22893788 27684546 24662831 25333250 20399964 11877389 14563837 18408012 17052453 18455992 15212693 16371461 11274345
TCF7L2 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17306568 17666529 23343194 21285352 15576399 21151179 22761862 22290435 16039586 19619488 19623618 17143292
CTNNB1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 19751508 7542250 11967263 22290435 19623618 16574648 23343194 11955436 22270359 22761862 16039586 15810077 17143292 12051714 8666229 22943793 15576399 21151179 16940750 17306568 17666529 21285352 19619488
LEF1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 19751508 7542250 11967263 22290435 19623618 23343194 11955436 22270359 22761862 16039586 15810077 17143292 12051714 8666229 22943793 15576399 21151179 16940750 17306568 17666529 21285352 19619488
DVL3 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 15806138 16510874 22290435 18627596 19623618 11929833 23343194 15768032 22761862 17050667 16039586 20122174 17291450 20920541 17143292 20006983 17439715 15576399 21767405 23306204 8545107 22705350 18347071 16007074 16169192 21285352 20530697 19619488 11274345
MYC CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 8425218 15121849 11602341 2006410 17873522 21406394 12584560 17558397 20551172 15814658 16908182
MYC SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 11804592
MYC SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 11804592
NFAT5 TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11485737 16027109
PRKCD TP73 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12097319 21188172
PRKCD STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 76.0 1.0 Omnipath 8272872 19413330 11335711 15677447 9343414 15465816 8140422 12576423 11350938 7678052 20068231 12754507 9880505 12763138 9872331 18491316 18669648 8662591 10521505 18691976 27036017 27458446 7537214 8626374 20058876 25280942 16951338 14551213 8164674 12754506 10446219 12361954 12754505 16418226
PRKCD ITGB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 23823319 16301335 29903913 11700305 17107954 18550856 25278023 12682249 15212693
PRKCD KLF5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12682370
RASSF1 STK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 17379520 24366813 26186194 14729613 22195963 24255178 20920251 21808241 21199877 19962312 20086174 32296183 17598981 29063833 18347058 17889669 23455922
SMAD4 SNAI2 â—¼   UP_REGULATES ✅ + 31.0 1.0 ACSN 11074002 11279127 11792802 12490555 12702545 12809600 14623871 15265520 16510505 16617148 16713975 16831886 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18832382 19208835 19412634 20731704 21199805 21317430 21614932 21883379 22006115 22406545 22945800 9389648
SNAI2 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 32.0 1.0 Omnipath 23031797 23189137 23054398 11912130 21081648 23160379 20455091 19635798 16943193 24424621 15300012 20139075 24703882 12855644 23637992 23518002 19448627 16273209 18385519 20071775 22933707 24297167 20332115 17655524 22899291 22567133 20053763 15311212 21593765 19389926 20182623 21796367
CTNNB1 SNAI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 20731704 19751508 7542250 11967263 22406545 17093497 21317430 11955436 22270359 18832382 12051714 8666229 12490555 16510505 16940750 21199805 17550342 16831886 14623871
LEF1 SNAI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 20731704 19751508 7542250 11967263 22406545 17093497 21317430 11955436 22270359 18832382 12051714 8666229 12490555 16510505 16940750 21199805 17550342 16831886 14623871
SNAI2 CDH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 15169839 17615296 22796940 20818389 21685935 22370643 20519943 12508111 17508028 11309385 19597490 14673164
STAT3 HIF1A â—¼   DOWN_REGULATES ✅ - 24.0 1.0 ACSN 10347215 10973499 12223527 14607900 14670306 15218058 15356132 15573129 16418395 18776941 18985005 19380816 20093776 20237412 20406969 20581311 21840487 23124025 23454751 23953057 24857661 27216177 28186502 7543512
STAT3 CCND3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16084951 18310224 15184887
STAT3 HIF1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19265129 18644974 16007214 20924113 17597020 23991099
STAT3 BIRC5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 19880237 26512963 15184887 15469392 16651438 18242580 16397018 21344490 20826784 24431073 15077160 12393476 19284568 17880940 17533050 17932422 22984561
STAT3 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15735682 18985005 10973499
STAT3 WNT5A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19424602 17203201
HIF1A TNF â—¼   ENZYMATIC_REACTION ✅ 28.0 1.0 ACSN 10754326 10804084 10952726 11875494 12907458 14660645 15465827 15644117 16110315 16127144 16878026 17404308 17485448 17533374 20427344 20535745 20855962 21051947 21765015 22006996 22850421 22988108 23390297 24006507 25043024 25103413 25732824 7594497
CDH1 TNF â—¼   DOWN_REGULATES ✅ - 5.0 1.0 ACSN 11884419 16424155 16461340 17307799 17617594
PPARG TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 20376096 11009565 14646597 20473515 11124825 17532302 17464333 19031802 14656714
HIF1A TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 21386799 17451682 15604270 17548584 17884817 15925386 22320863 23359428 23085511 19766100 16007254 12479793
TP73 TP53BP2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11684014 18676979 14729977 18275817
YAP1 TP73 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 15678106 17110958 35044719 19111660 19788416 21808241 18280240 18640976 25283809 15893728 11278685 17889669 27292796
FZD7 WNT1 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 10862746 20006983 17433286 23396967 15143170 15169958 21316585 16495441 20940229 23140633
DVL2 WNT1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
AXIN1 WNT1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
DVL1 WNT1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
WNT1 DVL3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
WNT1 GSK3B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
WNT1 FZD2 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 11448771 11029007 15459103 12205098 22000856 22653731 11357136 15084453 23256519 23791946
WNT1 FZD1 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 10862746 20006983 17433286 23396967 15143170 15169958 21316585 16495441 20940229 23140633
WNT1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 21108734 7641885 15265686 19718039 21602792 210606194 8655584 19705439 19029934 20093472 17430994 21606194 17884187 14747478 16554443 18936100 22017973 22433869 17143292 20006983 19072724 14704854 16965538 16443747 22007144 16547521 19020754 20940130 21640127 21087212 17127310 15208637 21796133
WNT1 FZD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 14642436 15578921
WNT1 FZD8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15454084 1545408415454080 11448771
WNT1 FZD9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 91476519147651 9147651
WNT1 FZD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10557084 22944199 15578921 16936075 24032637
YAP1 WWTR1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 ACSN 12807903 18280240 18617895 21666501 23708000 25502501 26711338 7782338
YAP1 WWTR1 â—¼   PROTEIN_INTERACTION 8.0 1.0 ACSN 12807903 18280240 18617895 21666501 23708000 25502501 26711338 7782338
YAP1 SERPINE1 â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 12807903 18280240 18617895 21666501 23708000 25502501 26711338 7782338
LATS2 YAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 36.0 1.0 Omnipath 22863277 20048001 18413746 24525530 15302935 19797269 17974916 18640976 18369314 29179447 18669648 25670202 26578655 29680477 18565851 21233212 21041410 18158288 19919647 18220336 21832154 22658639 21041411 24976283 26598551
BTRC YAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20048001 23431053 24976009 21900206
AMOT YAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 32755583 21205866 26269582 21808241
CSNK1D YAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 24715453 23431053
LATS1 YAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 48.0 1.0 Omnipath 22863277 24366813 35044719 20048001 18413746 17889669 15302935 21383157 23752589 17974916 18640976 22641346 23027127 20841485 18369314 29179447 18669648 24255178 18565851 21909427 21170084 25283809 29487715 18158288 29496737 18220336 22658639 35210364 27325643 19141641 21041411 25180175 27322327 27847303
YAP1 SMAD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 22921829 12118366 25283809
YAP1 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19914168 35044719 23431053 21685363
YAP1 TEAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 24525233 25751140 11358867 25751139 26592798 23431053 32537835
YAP1 TEAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 25973055 26578655 11358867 25751139 20368466 23431053 35140242
YAP1 TEAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 22863277 11358867 25751140 30417565 24882516 26258633 23431053 24581491
PPP1CB AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17318175
DVL2 FZD7 â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 23821037 15936275 10698942 9716412 17130287 9674432 17627283 11358862 11101902 12015986 14636582
FZD7 WNT11 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 10862746 20006983 17433286 23396967 15143170 15169958 21316585 16495441 20940229 23140633
WNT2 FZD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23815780
WNT11 FZD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10862746
WNT3A FZD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18215320
WNT3 FZD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 25892522 18313787 24032637
WNT5A FZD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10990458
TCF7L2 AXIN2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15473860 11809809 24447505 11809808 12711682 11940574
CTNNB1 AXIN2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 24447505 15473860 11809809 22615875 11809808 12711682 11940574
LEF1 AXIN2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 19751508 7542250 8666229 11955436 11967263 22270359 16940750 12051714
CTNNB1 AXIN2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 10966653 19751508 7542250 8666229 17143292 11955436 11967263 23343194 22270359 9554852 22699938 16039586 16940750 9566905 19619488 15766563 12051714
AXIN2 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15611123 10966653 10911903 888800000547 9554852 22745173 9566905 22322943
BMP7 BMPR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15621726 106311828605097 8605097 10631182
BMP7 BMPR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 18342887 16446785 7791754 7644468
BMP7 BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 16189514 7791754 12297674 8605097
CCN2 ITGB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12736251
HIF1A ITGB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 7539918 15235127 1823643 16716598 12829734 9159130 13130303 9746763 12080085 11566883 10403805 8943284 15451019 9278421 16887934
TGFB1 ID2 â—¼   DOWN_REGULATES ✅ - 27.0 1.0 ACSN 11133108 11708773 12490555 14557817 15111329 15181457 15252039 15548370 16474430 16607286 16716598 17615296 17934056 18403754 19010789 19109155 19920116 20519943 20644162 21041997 21278795 21900405 21909923 22703233 7594497 9157999 9335507
HIF1A ID2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 15252039 7539918 17615296 11708773 1823643 12829734 9159130 13130303 9746763 11566883 12080085 10403805 8943284 15451019 9278421 16887934 15181457
CTNNB1 ID2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 15252039 19751508 7542250 17615296 8666229 11708773 11967263 11955436 22270359 16940750 12051714 15181457
ID2 MYOD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 9242638 8380166 21209940 1922066
ID1 MYOD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 12145280 9242638 15029197 8380166 20195544 9528857 1922066 18674781
SMAD3 SMAD4 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
SMAD2 SMAD4 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
SMAD4 SMAD3 â—¼   PHYSICAL_INTERACTION 72.0 1.0 ACSN 10454538 10925299 10964912 11007770 11013125 11013220 11074002 11114293 11224571 11279127 11283613 11283614 11376132 11399519 11792802 11875494 12193690 12545156 12702545 12809600 14976548 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 16831886 17018611 17055429 17260466 17550342 17563753 17689680 17705132 18353785 18768831 18832382 19208835 19597490 19815509 19901969 20027199 20713526 20731704 21041997 21042762 21098712 21252118 21317430 21577210 21614932 2191300 22331441 22514743 22652804 23140366 23338822 23390297 23784029 23869868 25374926 6357187 8515656 8871614 8893010 9312026 9389648 9618481 9670020
SMAD4 SMAD2 â—¼   PHYSICAL_INTERACTION 52.0 1.0 ACSN 10454538 10925299 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11399519 11792802 11875494 12193690 12545156 12702545 12809600 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 17055429 17260466 17550342 17689680 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23390297 23784029 23869868 6357187 8515656 8871614 9312026 9389648 9618481 9670020
SMAD4 SMAD3 â—¼   PROTEIN_INTERACTION 72.0 1.0 ACSN 10454538 10925299 10964912 11007770 11013125 11013220 11074002 11114293 11224571 11279127 11283613 11283614 11376132 11399519 11792802 11875494 12193690 12545156 12702545 12809600 14976548 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 16831886 17018611 17055429 17260466 17550342 17563753 17689680 17705132 18353785 18768831 18832382 19208835 19597490 19815509 19901969 20027199 20713526 20731704 21041997 21042762 21098712 21252118 21317430 21577210 21614932 2191300 22331441 22514743 22652804 23140366 23338822 23390297 23784029 23869868 25374926 6357187 8515656 8871614 8893010 9312026 9389648 9618481 9670020
SMAD4 SMAD2 â—¼   PROTEIN_INTERACTION 52.0 1.0 ACSN 10454538 10925299 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11399519 11792802 11875494 12193690 12545156 12702545 12809600 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 17055429 17260466 17550342 17689680 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23390297 23784029 23869868 6357187 8515656 8871614 9312026 9389648 9618481 9670020
TGFBR2 SMAD4 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11274345 14557817 15265520 16474430 17934056 20060931 20519943 21614932 22703233 24132110 24336330
TGFBR1 SMAD4 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11274345 14557817 15265520 16474430 17934056 20060931 20519943 21614932 22703233 24132110 24336330
SMAD4 GLI2 â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 8515656 9389648
SMAD4 ID1 â—¼   DOWN_REGULATES ✅ - 13.0 1.0 ACSN 11074002 11279127 11792802 12702545 12809600 15265520 16713975 16831886 17490644 18832382 21614932 23850759 9389648
SMAD4 SMAD3 â—¼   LOCALISATION ✅ 72.0 1.0 ACSN 10454538 10925299 10964912 11007770 11013125 11013220 11074002 11114293 11224571 11279127 11283613 11283614 11376132 11399519 11792802 11875494 12193690 12545156 12702545 12809600 14976548 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 16831886 17018611 17055429 17260466 17550342 17563753 17689680 17705132 18353785 18768831 18832382 19208835 19597490 19815509 19901969 20027199 20713526 20731704 21041997 21042762 21098712 21252118 21317430 21577210 21614932 2191300 22331441 22514743 22652804 23140366 23338822 23390297 23784029 23869868 25374926 6357187 8515656 8871614 8893010 9312026 9389648 9618481 9670020
SMAD2 SMAD4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16052471 11376804 11456453 9812998
SMAD4 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21836474 21926264 16580992 12524424
SMAD4 SMAD7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 10823886 15183844 10887185 19032343 10839991 16442497 10753944 10843994 15128733 10559222
SMAD4 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10964912 15647271 10843986 21968601
SMAD4 SERPINE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9792626 19752858 9765209 12551947 10636910 10092624 9606191
SMAD3 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 104.0 1.0 Omnipath 25609649 9843571 15084259 20211142 21532621 24584437 18729074 23788427 12419246 18923419 9892009 19768112 10531362 15231748 9679060 12167862 21988832 12150994 23331499 12543979 18568018 21071413 19135894 15467747 25502805 9732876 11927552 16189514 12917407 25514493 15350224 10995777 18988627 10092624 12732634 25910212 10878024 9111321 20564330 27107012 9311995 12957874 20142324 11114293 32296183 15588252 15761153 24157709 26555259 29892012 17469184 22442258 16714330 21597466 15922743 22045334 17591701 24382352 22310290 19139564 19917253 29997244 31515488 28115363 10942775 21297662 17283070 12794086
SMAD2 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 110.0 1.0 Omnipath 15613484 17145710 25609649 15817471 20211142 21532621 24584437 18729074 23788427 12419246 16916642 9288972 9892009 21454478 17510063 10531362 15231748 11027280 12167862 21988832 9389648 23331499 12543979 18568018 21071413 19135894 18511908 15467747 12808092 11927552 25514493 15350224 18988627 12732634 10878024 9111321 9311995 9346908 10199400 11264182 12957874 11114293 15761153 11274206 12621041 17272273 24157709 26555259 12374795 22442258 10781087 15922743 11102446 17591701 18783722 16751102 19139564 19917253 9346966 21297662 17283070 12794086
TGFBR2 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8774881 20060931 11274345 21614932
BTRC SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 15855639 15314162 16865698 26022109 25373906 16189514 14988407
SMAD1 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 34.0 1.0 Omnipath 17183365 9436979 24412244 11779505 31467278 21454478 10531362 15231748 12167862 23331499 21071413 11700304 12874272 16189514 18988627 20957627 9111321 15761153 32296183 26555259 14701756 14534577
TGFBR1 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8774881 20060931 11274345 21614932
SMAD4 LEF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 10890911 21071413 18988627
SMAD4 ID1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 9389648 18832382 16831886 11074002 17490644
TGFB1 TGFBR2 â—¼   PHYSICAL_INTERACTION 75.0 1.0 ACSN 10678166 11013220 11133108 11274345 11278410 11279127 11792802 12154066 12717440 12724770 12738796 12767520 12809600 14557817 15003992 15099563 15265520 15282297 15548370 15653932 15761148 15761153 16127449 16200688 16424049 16474430 16572188 17070508 17404308 17673906 17768418 17934056 17979848 18423981 18490733 18758450 18855897 18922473 19010789 19038247 19050695 19109155 19732719 19747910 19920116 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 21900405 22315516 22703233 22710166 22874531 22943793 22949611 23034983 23070005 23784029 24132110 24336330 24403530 26201938 26966341 2871107 7594497 8515656 9311995 9865696
TGFBR2 TGFBR1 â—¼   PHYSICAL_INTERACTION 75.0 1.0 ACSN 10678166 11013220 11133108 11274345 11278410 11279127 11792802 12154066 12717440 12724770 12738796 12767520 12809600 14557817 15003992 15099563 15265520 15282297 15548370 15653932 15761148 15761153 16127449 16200688 16424049 16474430 16572188 17070508 17404308 17673906 17768418 17934056 17979848 18423981 18490733 18758450 18855897 18922473 19010789 19038247 19050695 19109155 19732719 19747910 19920116 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 21900405 22315516 22703233 22710166 22874531 22943793 22949611 23034983 23070005 23784029 24132110 24336330 24403530 26201938 26966341 2871107 7594497 8515656 9311995 9865696
TGFB1 TGFBR2 â—¼   SHARES_COMPLEX 75.0 1.0 ACSN 10678166 11013220 11133108 11274345 11278410 11279127 11792802 12154066 12717440 12724770 12738796 12767520 12809600 14557817 15003992 15099563 15265520 15282297 15548370 15653932 15761148 15761153 16127449 16200688 16424049 16474430 16572188 17070508 17404308 17673906 17768418 17934056 17979848 18423981 18490733 18758450 18855897 18922473 19010789 19038247 19050695 19109155 19732719 19747910 19920116 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 21900405 22315516 22703233 22710166 22874531 22943793 22949611 23034983 23070005 23784029 24132110 24336330 24403530 26201938 26966341 2871107 7594497 8515656 9311995 9865696
TGFBR2 TGFBR1 â—¼   SHARES_COMPLEX 75.0 1.0 ACSN 10678166 11013220 11133108 11274345 11278410 11279127 11792802 12154066 12717440 12724770 12738796 12767520 12809600 14557817 15003992 15099563 15265520 15282297 15548370 15653932 15761148 15761153 16127449 16200688 16424049 16474430 16572188 17070508 17404308 17673906 17768418 17934056 17979848 18423981 18490733 18758450 18855897 18922473 19010789 19038247 19050695 19109155 19732719 19747910 19920116 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 21900405 22315516 22703233 22710166 22874531 22943793 22949611 23034983 23070005 23784029 24132110 24336330 24403530 26201938 26966341 2871107 7594497 8515656 9311995 9865696
TGFB1 TGFBR2 â—¼   ENZYMATIC_REACTION ✅ 75.0 1.0 ACSN 10678166 11013220 11133108 11274345 11278410 11279127 11792802 12154066 12717440 12724770 12738796 12767520 12809600 14557817 15003992 15099563 15265520 15282297 15548370 15653932 15761148 15761153 16127449 16200688 16424049 16474430 16572188 17070508 17404308 17673906 17768418 17934056 17979848 18423981 18490733 18758450 18855897 18922473 19010789 19038247 19050695 19109155 19732719 19747910 19920116 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 21900405 22315516 22703233 22710166 22874531 22943793 22949611 23034983 23070005 23784029 24132110 24336330 24403530 26201938 26966341 2871107 7594497 8515656 9311995 9865696
TGFBR2 SMAD3 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11274345 14557817 15265520 16474430 17934056 20060931 20519943 21614932 22703233 24132110 24336330
TGFBR2 SMAD2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11274345 14557817 15265520 16474430 17934056 20060931 20519943 21614932 22703233 24132110 24336330
TGFBR2 TGFBR1 â—¼   ENZYMATIC_REACTION ✅ 75.0 1.0 ACSN 10678166 11013220 11133108 11274345 11278410 11279127 11792802 12154066 12717440 12724770 12738796 12767520 12809600 14557817 15003992 15099563 15265520 15282297 15548370 15653932 15761148 15761153 16127449 16200688 16424049 16474430 16572188 17070508 17404308 17673906 17768418 17934056 17979848 18423981 18490733 18758450 18855897 18922473 19010789 19038247 19050695 19109155 19732719 19747910 19920116 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 21900405 22315516 22703233 22710166 22874531 22943793 22949611 23034983 23070005 23784029 24132110 24336330 24403530 26201938 26966341 2871107 7594497 8515656 9311995 9865696
TGFB2 TGFBR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 8106553 1310899 23331499 21071413 12729750 16446785 12809600 11157754
TGFB1 TGFBR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 122.0 1.0 Omnipath 1310899 22874531 8047140 11279127 22710166 7878020 16424049 17673906 24132110 18922473 22943793 12729750 16446785 20519943 7706250 15761153 7594497 15548370 15761148 15265520 19010789 26194464 7852346 12717440 17768418 19050695 11133108 14557817 11278410 19920116 22949611 22703233 23331499 23070005 20060931 17070508 21614932 1333888 10716993 16572188 20860622 11323414 21900405 12724770 8106553 23034983 26192618 2871107 12809600 11382746 21372296 20538542 16200688 11792802 26201938 24403530 15099563 11013220 17979848 21054789 23784029 15003992 20644162 8515656 7935686 11157754 20856203 18382895 15282297 18855897 9865696 21441952 10678166 16127449 21041659 10026191 22315516 12767520 17404308 19732719 20616810 21071413 17934056 12738796 18423981 21098712 19747910 9311995 15034927 11274345 12154066 18758450 24336330 21278795 26966341 9261125 16474430 15653932 18490733 8242742 19038247 19109155
TGFBR2 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 10678166 9463378 11792802 11133108 19920116 14557817 11278410 15178549 20060931 17934056 21614932 8980228 9311995 20519943 21900405 15548370 19010789 15104092 16474430 30093905 11274345 9865696
TGFBR2 SMAD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11278251 15221015 11163210
TGFBR2 TGFBR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 48.0 1.0 Omnipath 7774578 9463378 19556242 8047140 23868260 18243111 7890683 10026191 23331499 8576253 21071413 7878020 21791611 10716993 18988627 11278251 19758997 25825445 22802914 16446785 11483955 8947046 11323414 11124802 15221015 11102446 11387212 12809600 7566156 26194464
SMAD3 SMAD7 â—¼   PHYSICAL_INTERACTION 13.0 1.0 ACSN 11279127 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21614932 22331441 23784029 8515656
SMAD2 SMAD7 â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 11074002 11279127 15265520 16179589 16713975 21042762 21614932 22331441 23784029 9670020
SMAD7 TGFBR1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 ACSN 11279127 15265520 22286770 23784029
SMAD2 SMAD7 â—¼   PROTEIN_INTERACTION 10.0 1.0 ACSN 11074002 11279127 15265520 16179589 16713975 21042762 21614932 22331441 23784029 9670020
SMAD3 SMAD7 â—¼   PROTEIN_INTERACTION 13.0 1.0 ACSN 11279127 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21614932 22331441 23784029 8515656
SMAD7 TGFBR1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 11279127 15265520 22286770 23784029
SMAD2 SMAD7 â—¼   DOWN_REGULATES ✅ - 10.0 1.0 ACSN 11074002 11279127 15265520 16179589 16713975 21042762 21614932 22331441 23784029 9670020
SMAD3 SMAD7 â—¼   DOWN_REGULATES ✅ - 13.0 1.0 ACSN 11279127 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21614932 22331441 23784029 8515656
TGFB1 SMAD7 â—¼   UP_REGULATES ✅ + 27.0 1.0 ACSN 11133108 11708773 12490555 14557817 15111329 15181457 15252039 15548370 16474430 16607286 16716598 17615296 17934056 18403754 19010789 19109155 19920116 20519943 20644162 21041997 21278795 21900405 21909923 22703233 7594497 9157999 9335507
SMAD3 SMAD7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 10823886 15183844 12761881 10887185 10973944 10839991 10753944 10843994 15579469 10559222
SMAD2 SMAD7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15183844 10887185 10753944 10843994 10559222
SMAD7 CCN2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 17657819 19667256 19959709 19397700 20222112
SMAD7 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 10887185 15855807 9886263 20631490 22656308 19214138 23633623 14600158 10753944 11912247 11385614 11180003 17928287 19010789 22496417 22841502 17074765 15496141 11448947
CTNNB1 SMAD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 15684397 21071413 18988627
TGFB1 SMAD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 19010789 14718519 16474430 17934056 20519943 9335507 21900405 11133108 14557817 15548370 19920116
SMAD7 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 21071413 9892009 26555259 9892110
SMAD7 TGFBR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 9335505 21897371 9335507 17314099 12151385 9892110 23331499 22921829 21071413 21791611 18988627 11278251 16571110 14657019 18725536 15761153 11163210 15221015 30017632 22286770 15148321 20663871 14722617 9215638
SMAD7 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 17438144 21071413 9892009 9892110
SMAD3 SMAD2 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10454538 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23869868 8515656 9312026 9389648 9618481 9670020 9865696
SMAD3 SMAD2 â—¼   PROTEIN_INTERACTION 41.0 1.0 ACSN 10454538 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23869868 8515656 9312026 9389648 9618481 9670020 9865696
TGFB1 SMAD2 â—¼   ENZYMATIC_REACTION ✅ 30.0 1.0 ACSN 10678166 11013220 11133108 11278410 11792802 12154066 12717440 12724770 14557817 15265520 15548370 16474430 17934056 19010789 19050695 19109155 19920116 20060931 20519943 20644162 21278795 21614932 21900405 22703233 22710166 24132110 24336330 7594497 9311995 9865696
TGFBR1 SMAD2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11274345 14557817 15265520 16474430 17934056 20060931 20519943 21614932 22703233 24132110 24336330
SMAD2 SERPINE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15198928 23063463 19132220 11879191
SMAD2 CCN2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 22576977 15883213 19309720 23631855 19397700 11991857
TGFB1 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 15548370 19010789 10678166 16474430 9311995 23831640 17934056 20519943 24075003 11792802 11133108 21900405 14557817 11278410 19920116 9865696
TGFBR1 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 74.0 1.0 Omnipath 10678166 12220225 9892009 9463378 16024789 9136927 14625308 11792802 11133108 19920116 14557817 11278410 15134444 10085140 23331499 21071413 20060931 17934056 18511908 21614932 18988627 10973958 23221174 8980228 9311995 9346908 9235954 20519943 21900405 15350225 15548370 26057631 19010789 15104092 16474430 9346966 30093905 12957874 11744690 9525694 15212693 11274345 9865696
SMAD2 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 21988832 26186194 12543979 9111321 15084259 9311995 25878769 18729074 12700238
SMAD2 LEF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 10890911 21071413 18988627
TGFB1 SMAD3 â—¼   PHYSICAL_INTERACTION 30.0 1.0 ACSN 10678166 11013220 11133108 11278410 11792802 12154066 12717440 12724770 14557817 15265520 15548370 16474430 17934056 19010789 19050695 19109155 19920116 20060931 20519943 20644162 21278795 21614932 21900405 22703233 22710166 24132110 24336330 7594497 9311995 9865696
TGFB1 SMAD3 â—¼   SHARES_COMPLEX 30.0 1.0 ACSN 10678166 11013220 11133108 11278410 11792802 12154066 12717440 12724770 14557817 15265520 15548370 16474430 17934056 19010789 19050695 19109155 19920116 20060931 20519943 20644162 21278795 21614932 21900405 22703233 22710166 24132110 24336330 7594497 9311995 9865696
TGFBR1 SMAD3 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11274345 14557817 15265520 16474430 17934056 20060931 20519943 21614932 22703233 24132110 24336330
TGFB1 SMAD3 â—¼   ENZYMATIC_REACTION ✅ 30.0 1.0 ACSN 10678166 11013220 11133108 11278410 11792802 12154066 12717440 12724770 14557817 15265520 15548370 16474430 17934056 19010789 19050695 19109155 19920116 20060931 20519943 20644162 21278795 21614932 21900405 22703233 22710166 24132110 24336330 7594497 9311995 9865696
SMAD3 GLI2 â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 8515656 9389648
SMAD3 SERPINE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 19643931 15840021 19563779 12551947 24330518 9792626 19132220 19887897 11590145 9765209 19586629 18333754 16169848 15561701 10092624 10557285 20093492 11387330 9606191 17761371 23063463 15198928 9380693
SMAD3 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 26553048 27974707 10708950 19214138
SMAD3 CCN2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 20222112 21986102 22329991 15987746 19309720 22576977 23249750 11590167 16469114 19570811
SMAD3 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21836474 21926264 12457461 12524424
DVL1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 15888125 12650946 15955531
BTRC SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11359933
AXIN1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11438668 23331499 18988627
GSK3B SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23331499 18172167 21071413 21310903 23077590 28756206 19114991 19002158
TGFBR1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23331499 15104092 9311995 8774881 25714018 11438668 19458083 11792802 12957874 19701891 9380693
TGFB1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21557273 24899689 24075003 24485922 28756206 32196115
SMAD3 LEF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 10890911 21071413 18988627
SMAD3 RUNX2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 21986102 10962029 15084595 11331591 10531362
TGFB1 TGFBR1 â—¼   PHYSICAL_INTERACTION 75.0 1.0 ACSN 10678166 11013220 11133108 11274345 11278410 11279127 11792802 12154066 12717440 12724770 12738796 12767520 12809600 14557817 15003992 15099563 15265520 15282297 15548370 15653932 15761148 15761153 16127449 16200688 16424049 16474430 16572188 17070508 17404308 17673906 17768418 17934056 17979848 18423981 18490733 18758450 18855897 18922473 19010789 19038247 19050695 19109155 19732719 19747910 19920116 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 21900405 22315516 22703233 22710166 22874531 22943793 22949611 23034983 23070005 23784029 24132110 24336330 24403530 26201938 26966341 2871107 7594497 8515656 9311995 9865696
TGFB1 TGFBR1 â—¼   SHARES_COMPLEX 75.0 1.0 ACSN 10678166 11013220 11133108 11274345 11278410 11279127 11792802 12154066 12717440 12724770 12738796 12767520 12809600 14557817 15003992 15099563 15265520 15282297 15548370 15653932 15761148 15761153 16127449 16200688 16424049 16474430 16572188 17070508 17404308 17673906 17768418 17934056 17979848 18423981 18490733 18758450 18855897 18922473 19010789 19038247 19050695 19109155 19732719 19747910 19920116 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 21900405 22315516 22703233 22710166 22874531 22943793 22949611 23034983 23070005 23784029 24132110 24336330 24403530 26201938 26966341 2871107 7594497 8515656 9311995 9865696
TGFB1 TGFBR1 â—¼   ENZYMATIC_REACTION ✅ 75.0 1.0 ACSN 10678166 11013220 11133108 11274345 11278410 11279127 11792802 12154066 12717440 12724770 12738796 12767520 12809600 14557817 15003992 15099563 15265520 15282297 15548370 15653932 15761148 15761153 16127449 16200688 16424049 16474430 16572188 17070508 17404308 17673906 17768418 17934056 17979848 18423981 18490733 18758450 18855897 18922473 19010789 19038247 19050695 19109155 19732719 19747910 19920116 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 21900405 22315516 22703233 22710166 22874531 22943793 22949611 23034983 23070005 23784029 24132110 24336330 24403530 26201938 26966341 2871107 7594497 8515656 9311995 9865696
PPARG TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 14702344 17625041 31023188 17995524 16321227 18615188 14693716 12711314 16611854 18991162
HIF1A TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16896927 17053163 15611046 19211927 21209004 21057546 21055290
TGFB1 TGFBR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 22326956 10187774 7852346 22703233 12809600 7706250 11323414 8047140 8235612 26194464
TGFB2 TGFBR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 22326956 10187774 7608141 11157750 12809600 11157754
TGFBR1 PPP2R2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9774674
TGFBR1 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 19651622 9748228 9335504 10085121 9136927 15212693
DVL1 AXIN1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
AXIN1 FZD2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
AXIN1 FZD1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
AXIN1 WNT3A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
AXIN1 WNT8A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
AXIN1 DVL1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 ACSN 10428961 16288291 16940750 19751508 22270359 8666229
AXIN1 DVL1 â—¼   SHARES_COMPLEX 6.0 1.0 ACSN 10428961 16288291 16940750 19751508 22270359 8666229
DVL2 AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10329628 10829020 21245303 23892894 16713569 17529994
PPP1CA AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17318175
GSK3B AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 102.0 1.0 Omnipath 20128690 16944320 11738041 20043192 12511557 11967263 16890161 22613765 14663202 23602568 8524413 24451375 19303846 12554650 8638126 22509369 18593713 16199882 21988832 23331499 19759537 10428961 9482734 22270359 19202075 17570479 16293724 15327768 10581160 17318191 11487578 22773187 26496610 16568235 17318175 19131971 15465828 26912724 25241761 24976009 21242974 22682247 10228155 23579495 12584189 23959799 15020233 10421629 10488109 11278246 9501208 18632848 10481074 10535959 10318824 9554852 17601533 9832503 21502811 9734785 23455922
CSNK1D AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21316585 12000790
PPP1CC AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17318175
DVL1 AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 12556519 11278246 10862053 10330403 10330181 10428961 9482734 10196136 11027605 18339531
AXIN1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 52.0 1.0 Omnipath 20128690 20531388 16890161 27902311 22509369 18593713 16199882 23331499 9482734 21071413 26496610 19244247 22773187 17318191 10196136 18988627 17208333 19131971 24976009 22682247 10228155 12805222 12000790 10488109 9501208 9601641 18632848 9554852 19166851 23959799 12421363 9734785 11940574
DVL1 WNT8A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL1 FZD1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL1 FZD2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL1 GSK3B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
DVL1 WNT3A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
CSNK1D DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21316585 23331499 11818547
SMAD1 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12650946 23331499 16621789
DVL1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 25241761 10806215 20006983 15735151
KLF5 BIRC5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16595680 23869764
LEF1 BIRC5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17005722 19620402 11517919 16288908 17063141
HIF1A BIRC5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22925504 16847054 19245702 23732337
CTNNB1 BIRC5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19778454 17005722 19662654 11517919 16288908
PPARG CCN2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 19466435 16306131 16723090 31023188 18274641 19902320 11590167 18991162
PPARG SERPINE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 10329404 15990085 18278065 14581151 17906687 17995524 10073956 16843437 11230363
PPARG RUNX2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12878983 18715135 20589837 12704187
PPARG CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 12021175 15190077 20303941 14764597 19075513
CTNNB1 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 25721714 16847334 25168821 19495794
CDH1 CTNNB1 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
ID1 CDH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 23555842 16007183 17639499 17202424
GSK3B CDH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 16944320 11348595 11967263 14663202 8524413 20080742 19797085 12040186 16611981 10671551 16039586 12615961 15465828 17928543 24063632 10671552 15020233 19575820 17444818 20537194 17052453 9832503 18455992 16371461 11274345
CDH1 CTNNA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 17145710 7542250 19016843 25468996 9326449 16212417 11960376 11801604 8227214 10381631 16219695 9700170 24336504 22750944 9233779 11226248
CDH1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 91.0 1.0 Omnipath 17145710 7542250 11348595 9512503 10652321 19016843 16909210 9233779 17220478 16219695 27177845 25344754 11245482 22752307 16983094 16212417 16574648 18593713 9535896 9819408 12830000 10772923 11801604 23180380 8227214 16546130 10085258 22056988 9700170 12640114 24424122 10381631 17087658 24798214 11226248 12875984 9405455 11712088 12061792 17909039 22158051 11960376 14706341 11254878 15023525 12169098 21255999 16125672 22850631 16126725 11113628 25468996 9326449 17524503 17057644 7876318 11401320 22715382 7954478 18593907 21152425 22375065
DVL2 WNT11 â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 23821037 15936275 10698942 9716412 17130287 9674432 17627283 11358862 11101902 12015986 14636582
DVL2 WNT8A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL2 FZD2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL2 FZD1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL2 GSK3B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
DVL2 WNT3A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL2 WNT5A â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 23821037 15936275 10698942 9716412 17130287 9674432 17627283 11358862 11101902 12015986 14636582
FZD4 DVL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12958364 27096005 23331499
CSNK1D DVL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21316585 22609948 29426949 31579410
DVL3 FZD1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
GSK3B FZD1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
WNT11 FZD1 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 10862746 20006983 17433286 23396967 15143170 15169958 21316585 16495441 20940229 23140633
WNT3A FZD1 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 11448771 11029007 15459103 12205098 22000856 22653731 11357136 15084453 23256519 23791946
WNT8A FZD1 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 11448771 11029007 15459103 12205098 22000856 22653731 11357136 15084453 23256519 23791946
WNT5A FZD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10557084
WNT3 FZD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10557084
WNT3A FZD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 21078818 10557084 11029007 10601008
WNT2 FZD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10557084
WNT7B FZD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15923619
FZD1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 29.0 1.0 Omnipath 7641885 15265686 19718039 21602792 210606194 8655584 19705439 19029934 20093472 17430994 21606194 17884187 14747478 22017973 22433869 17143292 20006983 19072724 14704854 16965538 16443747 22007144 16547521 19020754 20940130 21640127 21087212 17127310 21796133
WNT2B FZD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 24032637 21856951
WNT7B FZD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15923619 24032637
WNT5A FZD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 10990458 16602827
HIF1A IGFBP1 â—¼   ENZYMATIC_REACTION ✅ 66.0 1.0 ACSN 10102273 10428030 10428780 10435632 10804084 10823814 11557773 11559532 11744734 11756417 11884613 12402042 12676992 12743597 14672622 14684737 14699081 14762718 15024076 15059920 15199147 15240700 15312748 15369676 15379897 15545625 16110315 16126909 16127144 16517405 16517406 16585195 16782875 16888645 17143338 17418790 17533374 17785433 18054315 18056423 18158893 18718909 19211554 20028863 20427344 20535745 20855962 21051947 21765015 22006996 22841746 22850421 22988108 24006507 25043024 25103413 25732824 7493931 7500013 7508926 8089148 8702901 8955077 9486205 9525945 9707622
HIF1A CCN2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23530034 20450254 17034590 15315937
HIF1A SERPINE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 19828020 10590062 11877282 17570486 18381294 9427542 14708599 17721610 15968405 16778202 17197388 19132225 20216986 21132271 14567996 14978738 20136501 17384280 12393531 19490965 8672239 11313255 20351105
CSNK1D HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20699359
WWTR1 SERPINE1 â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 12807903 18280240 18617895 21666501 23708000 25502501 26711338 7782338
LATS1 WWTR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 23026745 22078877 20412773 22658639 33086783 24550007 21808241 29787761 34022224 20594350
LATS2 WWTR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 22658639 18227151 21808241
WWTR1 TEAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 31515488 16189514 23431053
WWTR1 TEAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 31515488 16189514 32296183 23431053 20972459
BTRC GLI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 17053147 15340381 16611981 18813803 16651270 12820959 19797085 15071497 15688063 16371461
GSK3B GLI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 17444818 16611981 20537194 10671551 20080742 19797085 16039586 19575820 12040186 17052453 12615961 18455992 16371461 11274345
FBXW11 GLI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 17053147 15340381 16611981 18813803 16651270 12820959 19797085 15071497 15688063 16371461
CSNK1D GLI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 21233202 7641885 16611981 21536646 19797085 18455992 16371461
PRKCZ PARD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 24152735 23109003 17353362 12390250
PRKCZ GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 18353303 14657655 11481324
SMAD1 ID1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18381431 15331632 20522807 12296825
SMAD1 BMP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 14551209 11786386 21471203 19836350 11585340 22072987
BMPR1A SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11438941 24412244 19620713 9136927 16189514 11792802
GSK3B SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 18045539 25241761
BMPR1B SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 9748228 23331499 9335504 10085121 19620713 9766532 9136927 11792802 15212693
SOX9 AMH â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9707325 24705165 21187121 12732652 9774680 14689607 11097782 11259267
LATS2 YWHAG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21118956 25086053
YWHAE YWHAG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 21988832 20936779 17085597 12507503 17979178
YWHAG YWHAE â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 21988832 20936779 17085597 12507503 17979178
YWHAG YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17085597 21827211 12426317 15324660 15071501 12657644
YWHAH YWHAE â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 20936779 12507503 7615088 26496610 17979178
YWHAE YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 21988832 20936779 20618440 17085597 21827211 12426317 15071501 12657644 17979178
YWHAE YWHAH â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 20936779 12507503 7615088 26496610 17979178
SAV1 STK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 20562859 21988832 17379520 24366813 16930133 26186194 17145710 24255178 20920251 21084559 15688006 32296183 29063833 23455922
STK3 LATS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 26898830 21832154 15688006 23431053 21808241
STK3 MOB1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 23972470 18362890 23431053 21808241 32513747 30038061
STK3 MOB1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 19878874 32296183 23431053 21808241 18328708 19919647
STK3 LATS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 22195963 29970086 19962312 15688006 30038061
CTNNB1 CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 17666529 23343194 21285352 18974774 22761862 22290435 16039586 19619488 19623618 17143292
GSK3B CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 17486076 11152665 20537194 10385618 11124803 12969793 19757160 16732330 10486203 16039586 14536078 18167338 12459251 12615961
LEF1 CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 17666529 23343194 21285352 18974774 22761862 22290435 16039586 19619488 19623618 17143292
TCF7L1 CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 17666529 23343194 21285352 18974774 22761862 22290435 16039586 19619488 19623618 17143292
TCF7 CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 17666529 23343194 21285352 18974774 22761862 22290435 16039586 19619488 19623618 17143292
TCF7L2 CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 17666529 23343194 21285352 18974774 22761862 22290435 16039586 19619488 19623618 17143292
TCF7 CCND3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 17666529 23343194 21285352 18974774 22761862 22290435 16039586 19619488 19623618 17143292
TCF7L2 CCND3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 17666529 23343194 21285352 18974774 22761862 22290435 16039586 19619488 19623618 17143292
TCF7L1 CCND3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 17666529 23343194 21285352 18974774 22761862 22290435 16039586 19619488 19623618 17143292
LEF1 CCND3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 17666529 23343194 21285352 18974774 22761862 22290435 16039586 19619488 19623618 17143292
GSK3B CCND3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 22.0 1.0 Omnipath 11152665 20537194 10385618 15252116 11124803 16331257 12969793 19757160 16732330 10486203 16039586 14536078 18167338 15326477 12459251 12615961 17092340 15212693
CTNNB1 CCND3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 17666529 23343194 21285352 18974774 22761862 22290435 16039586 19619488 19623618 17143292
GSK3B DVL3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
GSK3B WNT3A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
GSK3B WNT8A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
GSK3B FZD2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
GSK3B CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 183.0 1.0 Omnipath 22415718 11967263 27158593 29455668 19303846 19797085 8638126 19293931 23056571 22662165 25352148 16611981 27068260 28337019 10671551 21743491 20688898 16293724 23721711 23552738 18687691 28977889 19622173 12051714 25241761 27683053 28549350 22699938 19565571 23076981 21562161 19575820 20219694 20537194 10330181 21986938 29183346 27773936 11251183 19711366 21035499 19675674 7542250 23151663 24451375 14663202 23804296 8524413 25639486 23770025 18070361 26892600 30143633 9233789 19667122 27507058 19061640 19223551 29387014 23331499 16199882 11533658 18644116 24501426 24913829 11835406 17318191 26014148 25366337 28183999 22640743 26910375 12000790 12114015 18387957 19107203 9832503 16371461 29805709 27462866 20137080 27902311 12040186 19576224 25644994 12615961 19060929 25897075 12851486 15465828 17053159 18952601 10228155 15020233 17444818 20140245 26453498 17052453 16944320 24015932 23602568 24975844 24931005 28948000 20080742 23209942 30271168 28220106 16520547 28430641 11818547 25546293 27672271 11955436 11154277 26373837 16039586 23778311 28697793 20302655 25136145 26905812 22216350 8666229 12957350 23109003 10074433 28529629 20215423 21329734 11254732 9501208 27098453 27281614 30279527 19631635 25482131 18455992 24403311 11274345
GSK3B KLF5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 24398687 20484041 28480051
TCF7L2 CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 24214913 14706452 19347947 24317174
CTNNB1 LEF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17785445 15473860 11326276 17335794 15728254
BTRC CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 68.0 1.0 Omnipath 23514615 17053147 22912335 17145710 27001857 20531388 18851830 12820959 24451375 18805092 25900982 11818547 16798748 19061640 19956254 23331499 24912152 19150432 22017875 24501426 28018973 16376880 21466614 27316454 19053519 26506240 14516475 25149538 10023660 22682247 10228155 9461217 24464578 18354482 26091241 10074433 12114015 9990852 14706645 18650423 25873176 19966869 25515538 20851351 22730322 24469040
CTNNA3 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 25241761 23136403 23718855 11590244 21598020
FBXW11 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 23331499 9784611 22682247 10074433
FZD5 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 29.0 1.0 Omnipath 7641885 15265686 19718039 21602792 210606194 8655584 19705439 19029934 20093472 17430994 21606194 17884187 14747478 22017973 22433869 17143292 20006983 19072724 14704854 16965538 16443747 22007144 16547521 19020754 20940130 21640127 21087212 17127310 21796133
CSNK1D CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 10488109 9312064 23331499 11955436 9482734 14966280 10023673 12000790 11818547 12114015
APC2 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 23331499 23840886 10021369 8638126 16510875 10980707 10074433 9823329
WNT2 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 7641885 15265686 19718039 21602792 210606194 8655584 19705439 19029934 20093472 17430994 21606194 17884187 14747478 22017973 22433869 17143292 20006983 19072724 14704854 16965538 16443747 22007144 16547521 19020754 20940130 21640127 21087212 17127310 21796133
WNT3A CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 31.0 1.0 Omnipath 21108734 7641885 15265686 19718039 21602792 210606194 8655584 19705439 19029934 20093472 17430994 21606194 17884187 14747478 22017973 22433869 17143292 20006983 24535659 19072724 14704854 16965538 16443747 22007144 16547521 19020754 20940130 21640127 21087212 17127310 21796133
CTNNB1 LEF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 50.0 1.0 Omnipath 16510874 23151663 11751639 15735151 17143293 16204248 23331499 12556497 21071413 14638683 15768032 18296023 12748295 21743491 11835406 16510875 18077326 8757136 9065403 20123964 15728254 17517646 21078818 15684397 8892228 10890911 15525529 12077367 9419974
CTNNB1 TCF7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 25678599 19358846 16442529 15735151 17143293 9065401
CTNNB1 TCF7L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 54.0 1.0 Omnipath 17145710 9488439 11713475 12446687 17143293 27902311 16569639 22014570 16724116 11955446 16442529 26350900 19202075 17050667 20126258 22056988 16306047 17914096 19443654 18391971 21670201 22155184 10080941 17283121 16230076 22304967 16630820 15684397 11713476 12861022 19304756 20492721 19816403 18772112
CSNK1D YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9360956 16045749 17081983 98030561
PRKCI PARD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17145710 14676191 22579248 27554858
YWHAH YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21827211 12657644 12426317 15071501
BMP4 BMPR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 7811286 8702914 11282024 8006002
BMPR2 BMPR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 21071413 16446785 18756288 10712517 7791754
BMP6 BMPR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 11401330 10504300
BMP2 BMPR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 7811286 12700180 9872992 10712517 15064755 19229295
BMP4 BMPR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 8702914 23331499 21071413 16446785 12045205 8006002 7673243 7644468
BMP4 BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 8702914 26330344 20860622 21054789 11241215 8006002 16189514 7644468
BMP2 BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 51.0 1.0 Omnipath 17145710 17483092 10880444 10712517 26330344 21054789 16672363 10881198 11263668 20860622 15064755 18937504 25938661 15621726 12700180 10692589 19804412
BMP2 BMPR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 10880440 23331499 11263668 23180781 18342887 16446785 10880444 10712517 7791754 17295905 25938661 24337809
WNT2 FZD8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23815780
WNT3 FZD8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 18528331 15454084
WNT3A FZD8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 22653731 20093360 22303445
WNT5A FZD8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 20093360 21518267
BMP5 BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11580864 16189514
BMPR2 BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18756288 7791754 10712517
BMP6 BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11401330 12297674 10504300
GDF6 BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9525338 160490149525338 16049014
GDF7 BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16049014
NF2 AMOT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 19615732 24366813 26045165 21481793 26549023 23414517
TCF7L2 LEF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15473860 20802155 17335794 11326276
BMP6 BMPR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 21071413 16446785 11401330 10504300
GDF7 BMPR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16049014
GDF6 BMPR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 9525338 16446785 18988627 160490149525338 16049014
WNT3A DVL3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
FZD2 DVL3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL3 WNT8A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
WNT4 FZD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12325120
WNT4 FZD6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 10557084 15265686 21541287
WNT3A FZD6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 21128903 21665003
WNT3A FZD5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17117926 22753465 24032637
WNT3A FZD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 18215320 19910923
WNT7A FZD5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 12857724 23331499 18567805 1285772412857720
WNT7A FZD9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15705594
WNT5A FZD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 16273260 21903638 15578921 17804197 24032637
WNT5A FZD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 2808370 9389482 19008118 24032637 19910923
WNT5A FZD6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16273260 21665003
WNT5A FZD5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 11029007 9054360
WNT2 FZD5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18302287 24032637
WNT2 FZD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19038973 24032637
WNT2 FZD9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 12138115 19038973
FZD2 WNT8A â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 11448771 11029007 15459103 12205098 22000856 22653731 11357136 15084453 23256519 23791946