Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
Graph tools:

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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
GNB2 SOD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
MYC PTPA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12747840
CCT5 ZNRD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
ZNRD2 CCT3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
CDK5 ACTR3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
MYC AIMP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11085504
FYN AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RAF1 AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19197339 7014125
RPS6KB1 AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5214238 11438723
AKT1 PTK6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15539407 20606012
MAPK8 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16306447
AKT1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17942906 9804616
AKT1 RPS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20605787
SUV39H1 ATP6V1B1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 23455924 8417751
BBS10 TCP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0910268107 20080638
BBS10 BBS12 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0910268107 20080638
BBS10 BBS7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0910268107 20080638
BBS12 BBS10 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0910268107 20080638
BBS12 TCP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0910268107 20080638
BBS12 CCT5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0910268107 20080638
BBS12 CCT4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0910268107 20080638
BBS12 CCT2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0910268107 20080638
BBS12 CCT3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0910268107 20080638
BBS12 CCT8 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0910268107 20080638
BBS2 BBS12 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0910268107 20080638
BBS7 CCT3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0910268107 20080638
BBS7 TCP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0910268107 20080638
BBS7 CCT4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0910268107 20080638
RYBP BMI1 â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 24981860
BUB1B HDAC5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7299731 19407811
XIAP CASP7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6547707 9525868
MYC CBX5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CCT3 EED â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
CCT3 RAF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216198 12620389
MYC CCT3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11983916
CCT5 IKBKE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
COPS5 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18926707
COPS5 TYK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24043623
SUV39H1 DCAF8 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 23455924 8417751
POC1A DLST â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
THBS3 DLST â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PSMD2 DLST â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
DLST TUBB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
DLST TUBB2A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
DUSP6 MAPK6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18632752
SDHA FCHSD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
HDAC6 FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
SUV39H1 FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 23455924 8417751
LCK FYN â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8946678 9973466
FYN MAP4K1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
FYN LCK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17570479 22043010
FYN VAV2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17570479 11262396
GABARAP HDAC5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
VHL GLI1 â—¼   COLOCALIZATION 2.0 0.8 intact 23395608 8412047
GPR37 PPM1J â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
GPR37 HSP90B1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
L3MBTL2 HDAC3 â—¼   COLOCALIZATION 2.0 0.8 intact 7719892 20385135
HDAC3 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22002311 18483244
TUBA1A HDAC6 â—¼   DEACETYLATION ✅ 2.0 0.8 intact 5215415 12024216
HDAC6 HSP90B1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19158084
HSP90AB1 IKBKE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
MYC HSP90AB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11983916
PPP2CB IGBP1 â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 27880917
TUBB IKBKE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
MAP1LC3A PRPF40A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
MYC VCAM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11318876 10528192
PDK1 TSSK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16336268
STRN PPP2CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8213804 18782753
PPP2R2A PPP2CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 1328247 19114990
PPP2CA RPS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15950189
PPP2R2A RPS6KB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16899564 10200280
RYBP SOD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TUBB SOD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TUBB2A TUBB2B â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
CCT2 CCT4 â—¼   CORRELATES + 0.8 0.8 CCLE 31978347
METTL14 METTL3 â—¼   CORRELATES + 0.8 0.8 CCLE 31978347
ACTA1 PPP1CC â—¼   PHYSICAL_INTERACTION 807.0 0.8 STRING 36370105
HSP90AB1 LRRK2 â—¼   PHYSICAL_INTERACTION 807.0 0.8 STRING 36370105
PPP2CA PPP4C â—¼   PHYSICAL_INTERACTION 807.0 0.8 STRING 36370105
CCT2 TCP1 â—¼   CORRELATES + 0.81 0.81 CCLE 31978347
ACTR2 ACTR3 â—¼   CORRELATES + 0.81 0.81 CCLE 31978347
RIPK4 CUL1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 26972000 29435596
AKT1 HSP90AB1 â—¼   PHYSICAL_INTERACTION 820.0 0.82 STRING 36370105
BBS7 RFWD3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
BBS7 MKKS â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22500027 20080638
BBS7 RIPK4 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
PCGF6 BMI1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 12167161 24981860
BMI1 PCGF3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22493164 24981860
BUB1B HDAC3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28985013 19407811
VCAM1 BUB3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
LRRK2 CDK5 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31046837 26268594
CELA1 HDAC3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
RAF1 DCAF8 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 16364241 34017080
FBXW8 OBSL1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 21572988 31343991
TBL1Y HDAC3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
LRRK1 LRRK2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 20144646 19712061
LRRK2 PSMD2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 31046837 24725412
MYC TTC27 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 17314511 29467282
MYC RRP1B â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 21150319 30415952
MYC U2AF2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30415952 29467282
POC1A POC1B â—¼   PHYSICAL_INTERACTION 820.0 0.82 STRING 36370105
VCAM1 PSMD2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
VCAM1 STRAP â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
CUL1 FBXW4 â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
BBS7 BBS12 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 22500027 20080638
FBXW8 CCDC8 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 21572988 31343991 24711643
CDK5 CCNE1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 28514442 23455922 23602568 33961781
HDAC6 CFTR â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 31501480 14675537 22069321
DCAF7 PCGF5 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 24981860 27705803
RAF1 LCK â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 8939988 16189514
MYC PCGF6 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 30415952 35140242 29467282
MYC PSMD2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 21150319 17314511 29467282
SOCS1 VAV2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 10022833 29991678
WDR5 SOX2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 30089852 29383478 35140242
CCDC8 OBSL1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
CUL7 OBSL1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
FBXW4 TXNDC9 â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
TUBA1A TUBB â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
LRRK2 TUBA1A â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
FBXW4 CUL1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 29103612 25143387 14603323 25515538 23658844
CUL1 FBXW8 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
PEX14 DNM1L â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 21525035 34079125
LRRK2 TTC27 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 31046837 29513927
CCT2 MKKS â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
BUB1B FZR1 â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
CCT3 CCT5 â—¼   CORRELATES + 0.84 0.84 CCLE 31978347
CCT5 CCT7 â—¼   CORRELATES + 0.84 0.84 CCLE 31978347
CUL1 VCP â—¼   PHYSICAL_INTERACTION 849.0 0.84 STRING 36370105
PPP1CC RRP1B â—¼   PHYSICAL_INTERACTION 849.0 0.84 STRING 36370105
PSMD2 VCP â—¼   PHYSICAL_INTERACTION 849.0 0.84 STRING 36370105
HDAC3 AKT1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 29523594 20026773
BMI1 EED â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 23238014 24457600
OBSL1 CUL7 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 21572988 31343991 21737058 25752541
MYC HDAC3 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 18483244 31155734 22002311 23079660
PCGF6 WDR5 â—¼   PHYSICAL_INTERACTION 850.0 0.85 STRING 36370105
PDK4 PDK3 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 33961781 28514442 32707033
CCT5 CCT8 â—¼   CORRELATES + 0.85 0.85 CCLE 31978347
PSMC6 VCP â—¼   PHYSICAL_INTERACTION 851.0 0.85 STRING 36370105
CCT7 IGBP1 â—¼   PHYSICAL_INTERACTION 855.0 0.85 STRING 36370105
CCT2 CCT3 â—¼   CORRELATES + 0.85 0.85 CCLE 31978347
PEX14 PEX7 â—¼   PHYSICAL_INTERACTION 860.0 0.86 STRING 36370105
RAF1 XIAP â—¼   PHYSICAL_INTERACTION 860.0 0.86 STRING 36370105
CCT2 CCT7 â—¼   CORRELATES + 0.86 0.86 CCLE 31978347
ACTA1 ACTR3 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
ARAF RAF1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 34017080 20130576 31980649
DCAF7 PCGF3 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 24981860 27705803
LCOR EED â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 26496610 24981860 27705803
SOX2 HDAC3 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 35140242 23667531 21532573
ILK RAF1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 25852190 23455922 26496610
MYC WDR5 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 31767764 35140242 17353931 29467282 30415952 27320920
FN1 VHL â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
FYCO1 MAP1LC3B â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
CCT2 CCT8 â—¼   CORRELATES + 0.87 0.87 CCLE 31978347
AIMP2 PARK2 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
PDK1 PDK3 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
ACTA1 ACTR2 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
TUBB TUBB2A â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
PDK3 PDHA1 â—¼   PHOSPHORYLATION ✅ - 0.87 0.87 Signor 11485553
TUBA1B TUBA1C â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
PPP2R2A PPP2R2D â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
ILK AKT1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 11825911 11546794 11313365 18339839 11278835 12149249 14500673 9736715 12176337 11445557 16189514
AKT1 PDK1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 34278744 27505672 27166089
AKT1 RAF1 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
BBS7 BBS10 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 28514442 20080638
CFTR PSMD2 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 29924966 17110338 31324722
SOCS1 FYN â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 10022833 16713569 29991678
HDAC5 HDAC3 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 11931768 11804585 21081666 11466315 10869435 10220385
IRAK1 IRF7 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 15767370 21903422
MAP1B LRRK2 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 21159966 24754922
PDHA1 PDK1 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
TUBB TUBB2A â—¼   CORRELATES + 0.88 0.88 CCLE 31978347
L3MBTL2 RYBP â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
HDAC6 TUBA1A â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
PCGF5 RYBP â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
PPP2CA PPP2R2B â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
PCGF3 RYBP â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
AKT1 PPP2CA â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
DNM1L LRRK2 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
SPRTN VCP â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
FBXW8 CUL1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 21572988 29103612 21145461 25515538 22268729 17205132 21946088
BBS7 BBS2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 27173435 29039417 17574030 20080638 28514442 22500027
CBX5 SUV39H1 â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
FBXW8 CUL7 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 21572988 12481031 18498745 23029530 31343991 23045529 17998335 17332328 16142236 10531037 21946088 17205132
CUL7 FBXW8 â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
DCAF7 RYBP â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 24981860 34316702 27705803 28514442
TYK2 FYN â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 9196040 16713569 16189514
RAF1 FYN â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 7517401 16189514 16713569
L3MBTL2 PCGF6 â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
CFTR VCP â—¼   PHYSICAL_INTERACTION 891.0 0.89 STRING 36370105
COPS5 VHL â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
COPS5 DDB2 â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
BMI1 RYBP â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
MYC PRKN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20638938 15078880 23277542
DYNC2I2 MAPK6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
MYC CUL1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10970882 12835716
MYC CUL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16376880 16915296
MYC TUBG2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12747840
ACTR1B MAPK6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
TNK2 AKT1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 10652228 11394904 18470881
MYC AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16846534 16489011 18562319
PPP1CC AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 14633703
GAN ATG16L1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20562859 30770803
MAPK6 BBS10 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
BBS10 HDAC6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
BBS2 BBS7 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
MYC BLK â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC CBX5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12747840
RPS6KA1 CCT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21440620
RPS6KA1 CCT4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
MYC CCT5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12747840
LRRK2 DNM1L â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 24282027 22228096 22639965 23813973 29541021
EED MAP1LC3B â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
FN1 ITGA4 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 20644254 22067905 24202395
FYN TUBA1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7678277 11826099
MAPK6 HDAC11 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
MYC HDAC3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
LCK RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7935389 8939988 16189514
MAPK6 TUBA1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
MYC RAF1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 28205554 17314511 28628118 9315742
MYC PEX14 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12747840
MYC PDHA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
PDK1 RPS6KA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10480933 17192257 7642538
PEX14 PEX7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16189514 15798189 10212238
RAF1 PPP2CA â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 502464200 8203796 16239230
RAF1 PPP2CA â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 intact 502464200 8203796 16239230
STRN PPP2CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 29802198 10681496 18782753
PPP2CB RPS6KB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 2826472 11124802 10200280
PPP2R2A RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15664191 23331499 16239230
RPS6KA1 VCP â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
VCP SPRTN â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 22902628 23042605 23042607
CCT4 CCT8 â—¼   CORRELATES + 0.9 0.9 CCLE 31978347
IGBP1 PPP4C â—¼   PHYSICAL_INTERACTION 0.9 0.9 HuRI 32296183
CCT3 CCT4 â—¼   CORRELATES + 0.9 0.9 CCLE 31978347
PPP2R2A PPP2CA â—¼   PHYSICAL_INTERACTION ✅ 0.91 0.91 mint 20711181 8288198
PPP2CB PPP4C â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
TUBA1A TUBB2B â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
TUBB TUBB3 â—¼   CORRELATES + 0.91 0.91 CCLE 31978347
TUBA1B TUBB â—¼   CORRELATES + 0.91 0.91 CCLE 31978347
PPP2CB PPP2R2B â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
HDAC3 HDAC5 â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
ATF2 MAPK8 â—¼   PHYSICAL_INTERACTION 919.0 0.91 STRING 36370105
PPP2R2A PPP2R2B â—¼   CORRELATES + 0.91 0.91 CCLE 31978347
CCT4 TCP1 â—¼   CORRELATES + 0.92 0.92 CCLE 31978347
HCFC2 WDR5 â—¼   PHYSICAL_INTERACTION 925.0 0.92 STRING 36370105
TUBA1B TUBB2B â—¼   PHYSICAL_INTERACTION 925.0 0.92 STRING 36370105
TUBA1B TUBB2A â—¼   CORRELATES + 0.92 0.92 CCLE 31978347
CCT4 CCT7 â—¼   CORRELATES + 0.93 0.93 CCLE 31978347
TUBB2A TUBB3 â—¼   CORRELATES + 0.93 0.93 CCLE 31978347
CCT7 TCP1 â—¼   CORRELATES + 0.93 0.93 CCLE 31978347
CCT8 TCP1 â—¼   CORRELATES + 0.93 0.93 CCLE 31978347
CCT3 TCP1 â—¼   CORRELATES + 0.93 0.93 CCLE 31978347
PPP4C IGBP1 â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 27880917
BBS10 CCT4 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
BBS10 CCT8 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
BBS10 CCT7 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
EEF2 RPS3 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
TUBA1A TUBA1B â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
CCT3 CCT8 â—¼   CORRELATES + 0.94 0.94 CCLE 31978347
FYN YES1 â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
CCT7 CCT8 â—¼   CORRELATES + 0.94 0.94 CCLE 31978347
TUBA1B TUBB â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
TUBA1B TUBB3 â—¼   CORRELATES + 0.94 0.94 CCLE 31978347
SUV39H1 CBX5 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 24981860
PPP2CA IGBP1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 8434208 23892082
CCT2 CCT5 â—¼   CORRELATES + 0.95 0.95 CCLE 31978347
CCT3 CCT7 â—¼   CORRELATES + 0.95 0.95 CCLE 31978347
BBS10 CCT2 â—¼   PHYSICAL_INTERACTION 955.0 0.95 STRING 36370105
BBS10 CCT3 â—¼   PHYSICAL_INTERACTION 955.0 0.95 STRING 36370105
PPP2CB PPP2R2D â—¼   PHYSICAL_INTERACTION 955.0 0.95 STRING 36370105
CCNC MED13 â—¼   PHYSICAL_INTERACTION 959.0 0.95 STRING 36370105
TUBA1A TUBB3 â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
TUBA1B TUBB2A â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
PPP2CA PPP2R4 â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
COPS5 CUL1 â—¼   PHYSICAL_INTERACTION 968.0 0.96 STRING 36370105
BUB3 BUB1B â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 33961781 11702782 29973720 26496610 27939943 25383541 25669885 22000412 20220147 25012665 25833949 12419313 25482201 28410192 32707033 32152539 11535616 22100920 25852190 28404789 24151075 21988832 25416956 22193957 28514442 16189514 23791783 25246557 21937719 19407811 26186194 9660858 25505175
BUB1B BUB3 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
TUBA1B TUBB3 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
CASP7 XIAP â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
TUBA1A TUBB2A â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
IGBP1 PPP6C â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
CCT3 STRN â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
CCT4 STRN â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
CCT5 STRN â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
CCT7 STRN â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
CCT7 PPP2R2C â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
CCT8 STRN â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
CCT8 PPP2CA â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
CCT8 PPP2R2C â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
CCT8 PPP2CB â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
STRN TCP1 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
CCT2 PPP2CA â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
CCT2 STRN â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
CCT2 PPP2CB â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
CCT2 PPP2R2C â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
CCT3 PPP2CA â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
CCT3 PPP2CB â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
CCT3 PPP2R2C â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
CCT4 PPP2CA â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
CCT4 PPP2R2C â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
CCT4 PPP2CB â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
CCT5 PPP2R2C â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
CCT5 PPP2CB â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
CCT5 PPP2CA â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
CCT7 PPP2CA â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
CCT7 PPP2CB â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
PPP2CA STRN â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
PPP2CA TCP1 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
PPP2CB STRN â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
PPP2CB TCP1 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
PPP2R2C TCP1 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
METTL14 METTL3 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CCNC CDK8 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
CCT4 CCT8 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PPP2CA PPP2R2C â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
CCT2 CCT3 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT2 CCT8 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT3 TCP1 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT3 CCT4 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT3 CCT7 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT4 CCT7 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT4 CCT5 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT7 CCT8 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT8 TCP1 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
PPP2CA PPP2R2D â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
PPP2CA PPP2R2A â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
PPP2CB PPP2R2A â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT2 CCT7 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT2 CCT4 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT2 CCT5 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT2 TCP1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT3 CCT5 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT3 CCT8 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT4 TCP1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT5 TCP1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT5 CCT7 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT5 CCT8 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT7 TCP1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
IGBP1 PPP2CB â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
IGBP1 PPP2CA â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
PSMC6 PSMD2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CDK5 PRKN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 19399218 24486837 17327227 19050041 29899409
PRKN AIMP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 16714300 27197155 16049031 12783850 16135753
PRKN CCNE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 20418918 12628165 15194120
PRKN GPR37 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 11439185 14579121 12666095 15194120 12150907
CCNE1 CUL1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 16209941 10375532 15199159 11231585
AKT1 CUL1 â—¼   ENZYMATIC_REACTION ✅ 45.0 1.0 ACSN 10722653 10949026 11274345 11715018 11756412 11756498 11923280 12408816 12906785 15169778 15808505 16469695 16697215 17052453 17461779 17680028 18000759 18372248 18492954 18570873 18636226 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20138985 20214616 20338997 20398329 20832730 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9812896
CUL1 ULK3 â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 15703371 16611981 16697054 17884153 18931676 19150432 19270156 19622404 19686080 19809470 19847258
AKT1 CUL1 â—¼   DOWN_REGULATES ✅ - 45.0 1.0 ACSN 10722653 10949026 11274345 11715018 11756412 11756498 11923280 12408816 12906785 15169778 15808505 16469695 16697215 17052453 17461779 17680028 18000759 18372248 18492954 18570873 18636226 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20138985 20214616 20338997 20398329 20832730 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9812896
CUL1 CCNE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 19847258 19686080 19270156 17884153 19622404 15703371 12648680 11900249 16697054 18931676 19809470 15459660
PTPA AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 21159657 18039929 19216069 23109003 10026142 10995457 18042541 20452955 18559511 18588945 16680151 19405949 16227604 16406523
ACTR2 ACTR3 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ACTR2 ACTR3 â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ILK AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 35.0 1.0 Omnipath 11546794 14500673 12176337 11445557 15899889 23840605 9736715 12149249 10592173 11313365 16189514 19460343 11278835 15212693 18772455 10226025 11825911
PPP2CB AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 15367694 11087733 18039929 19216069 18077353 19556239 19996169 10026142 10995457 18042541 20452955 18559511 8650155 18588945 16680151 11812651 20360384 16406523
PDK1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 12176337 15743829 12682057 11445557 15899889 12149249 10833263 15718470 11278835 10226025 11087733 14500673 16341064 19897009 9368760 24012393 11825911 9512493 9736715 11313365 9868760 15364915
PPP2R2A AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 18039929 19216069 18077353 19556239 19996169 10026142 10995457 18042541 20452955 18559511 18588945 16680151 20360384 16406523
TNK2 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 22322295 11394904 25678401 20333297 10652228
PPP2CA AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 35.0 1.0 Omnipath 21159657 26256536 15743829 10026142 20452955 11438723 18559511 11839802 19996169 19216069 16406523 10995457 18042541 19556239 18588945 16680151 11087733 18160256 15367694 18039929 18077353 11812651 16044149 20360384 12637511
PTK6 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 20606012 15994200 15539407
LRRK2 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 24916379 21658387
AKT1 RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 51.0 1.0 Omnipath 19197339 11971957 18767875 20230923 10576742 20068231 17570479 16189514 18669648 25241761 18691976 10576741 10618391 20688159 21745501 12087097 12801936 12048182 22798428 16854453 19058874 11997508
AKT1 XIAP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 23640046 25241761 17698078 14645242
AKT1 YAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 79.0 1.0 Omnipath 27979972 25360797 26804165 28273460 25751140 24101154 25751139 34052254 25362852 28114269 28793266 26265440 31239271 25601544 28474680 33630828 26119935 27144834 27425596 25531778 34206989 34465890 21945154 25195862 31792377 18640976 28775168 32015438 32523092 22234184 33536280 33622361 30600590 24362629 34155345 24658687 21060948 33162394 20153295 26668327 21730131 26549256 21666719 25605730 26039999 34226698 20823509 34516278 27033705 32064037 32271880 32513743 33990468 24812269 32053631 32929029 34058200 25772246 26364602 27765911 26678338 27979971 33552953 28171658 34129887 21376238 28416665 25998128 25109332 12535517 31988076 26933062 26598551 25373897
AKT1 BMI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22505453 23092893
AKT1 VCP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16551632 19335618 16027165
AKT1 IRAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 11976320
AKT1 RPS6KB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11943559 23331499 25241761 21071413 12183455 15149849 11438723
ARAF PPP1CC â—¼   DEPHOSPHORYLATION ✅ 14.0 1.0 Reactome 16294014 21779496 24211266 27264673 19684605 16041367 24347342 16630891 28666118 12932319 11756411 25907612 14530258 28289718
ATF2 RAF1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 11274345 12738796 18039929 20506250
ATF2 FN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21479385 8335091 10471826 8703044 9151819
MAPK8 ATF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 64.0 1.0 Omnipath 17145710 11279118 17081983 20506250 12958075 9162092 19255142 8654373 20028971 15105425 17626013 12788955 11566021 15550563 10777545 23331499 7535770 15068801 21071413 17875713 9317150 16393692 15304344 18988627 7737130 26538579 21444723 602896 11896587 12110590 7824938 11274345 12874243 11971971 9399639 19436832 16533805 9670022 9029150 11865055 9207092 12804775 7737129 15212693 9405416
MAPK13 ATF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 15187187 19436832 9207191 10581204 15140942 20506250 21614932 19135240 16393692 12244047 11274345
MYC BMI1 â—¼   UP_REGULATES ✅ + 32.0 1.0 ACSN 11274345 11283614 12545156 14536078 15147722 15155580 15279786 17055429 17303408 17550342 17558397 17660363 17873522 18590585 18636226 20027199 20237412 20551172 20581311 20713526 20818389 21406394 21733352 2191300 21919891 22067385 23140366 23869868 25002027 28536364 7575488 9618481
HDAC3 BMI1 â—¼   UP_REGULATES ✅ + 22.0 1.0 ACSN 11283614 12545156 12668723 15151915 15155580 15465827 16232121 17055429 17508028 17550342 20027199 20713526 20818389 21234400 21733352 2191300 21919891 22370643 22796940 23140366 23869868 9618481
XIAP CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 45.0 1.0 Omnipath 11447297 11257231 18521960 31467278 15200957 9384571 9545235 14512414 23979166 16189514 11359776 9230442 10508158 19559631 11257230 9525868 11583623 15580265 11257232 23074197 19698783
CDK8 CCNC â—¼   PHYSICAL_INTERACTION 1.0 1.0 HIPPIE 33961781 19914168 11416138 24981860 26496610 25344755 26502155 23602568 19047373 14681455 21806996 23746844 15328539 32707033 30695077 20098423 11867769 10353252 9710619 10882111 28514442 25416956 9150135 10024883 7568034 26186194 29568061 29997244
CDK8 CCNC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 21806996 23746844 26186194 19914168 20098423 19047373 23602568 7568034 25416956 29997244 10882111 15328539 25344755 9150135 11416138 10353252 26502155
MYC CCNE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 18802399 20607601 14519204 22583478 9188852 11983916 11509615
FYN CDK5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 24872417 19901323 9038181 10896159 18691976 20506281 29063113 20068231 16497976 19413330 14757045 12372285
CDK8 MED13 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 11001584 12417340 15279786 15337521 16007092 16413481 17000779 17303408 17565603 17660363 18590585 19879327 20144767 21327159 21330129 7575488 9216996
CDK8 MED13 â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 11001584 12417340 15279786 15337521 16007092 16413481 17000779 17303408 17565603 17660363 18590585 19879327 20144767 21327159 21330129 7575488 9216996
CDK8 GLI1 â—¼   DOWN_REGULATES ✅ - 5.0 1.0 ACSN 16413481 17000779 21327159 21330129 9216996
PDHA1 DLD â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11752427 2188967 11935326 9242632
DLD PDK4 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
DLD PDK1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
DLD PDK3 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
PPP2CA EEF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8386634 2555220 2176079
FN1 FYN â—¼   ENZYMATIC_REACTION ✅ 14.0 1.0 ACSN 12731048 18037882 19161977 19454690 19487819 20644254 20814939 22067905 22470492 24202395 9003039 9456329 9763606 9973479
MYC FN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 14519204 11896591 8376401 10421838
FN1 ITGA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 9117345 9842903 19738201 11010812
FYCO1 MAP1LC3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 27246247 26468287 20100911 20562859
FYCO1 MAP1LC3A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 27246247 26468287 20562859
ITGA4 FYN â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 12626562 19161977 19454690 19487819 22470492 9003039 9456329 9763606 9973479
LCK FYN â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 9822663 15886116 10849438 12670394
GLI1 ULK3 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 Reactome 20643644 22391301 18827223 12138125 12050670 19878745 18455992
GLI1 PRKACG â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 17283082 16421275 19056373 16705181
MED13 GLI1 â—¼   DOWN_REGULATES ✅ - 5.0 1.0 ACSN 16413481 17000779 21327159 21330129 9216996
RPS6KB1 GLI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 26512695 29163356 28735864 25476449 22439934 24661902 23880852 25134527
PPP4C HDAC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15805470
IGBP1 PPP2CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 23892082 21988832 20092282 16085932 18782753 24484909 28330616 9647778 21454489 26496610 32296183 24145130 19156129 11371618 10441131
IKBKE IRF7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 16625202 25225665 9786932 15210742 22787218 10893229 26712804 16127453 12702806 16380379 15367631 12692549 17706453 16199137 16914100
IRAK1 IRF7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15767370 17457343 21903422
VCAM1 ITGA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 22623428 19738201 11751331
LCK VAV2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11516622 12400014 17570479 12454019
MAPK8 RPS6KB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 21988832 17570479 11279232 23816567
MAPK8 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 19651622 10551811 17081983 18767875 20068231 91332050 1651323 1748630 16713569 11243879 18669648 15210690
MAPK8 PPM1J â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20865152 18553930
MYC PDK1 â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 11274345 11283613 11283614 11704864 16517405 16517406 17055429 17558397 17785433 17873522 20027199 20237412 20551172 20581311 20713526 21406394 2191300 22067385 25002027 28536364
MYC NME1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 18628958 12695333 14519204 16440314 11960382 11983916 18414489
MYC VHL â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22286234 12695333
PPP2CB MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 19131971 10026142 10995457 18042541 18559511 16987807 16680151 15048125
PPP2CA MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 19131971 10026142 10995457 18042541 18559511 16680151 15048125
MYC NME1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11960382 17093053
PDHA1 PDK4 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
PDHA1 PDK3 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
PDHA1 PDK1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7499431 11485553 9405293 8798399 11486000
PDK1 PDHA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 45.0 1.0 Omnipath 17081983 20166139 18767875 17474719 7782287 19415658 15302935 11485553 20068231 19341700 22195962 82003483 18691976 18088087 16436377 7273851 12676647 20058876 11486000 18212344
PDK3 PDHA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 44.0 1.0 Omnipath 17081983 20166139 18767875 17474719 7782287 19415658 15302935 11485553 20068231 19341700 82003483 18691976 18088087 16436377 7273851 12676647 20058876 11486000 18212344
PDK4 PDHA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 48.0 1.0 Omnipath 17081983 20166139 18767875 17474719 7782287 19690332 19415658 15302935 11485553 19341700 82003483 18691976 18088087 16436377 17487921 7273851 12676647 18220336 11486000 19081061 18212344
PDK1 RPS6KB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 11914378 17110931 12370290 15388791 15718470 16286006 20068231 9465032 15809305 16099428 14560963 11279232 9271440 9445476 18669648
PEX7 PEX14 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 21554508 24865970 19208625 26344566 8991089 27597759 18359941 26086376
RAF1 PPP1CC â—¼   DEPHOSPHORYLATION ✅ 14.0 1.0 Reactome 16294014 21779496 24211266 27264673 19684605 16041367 24347342 16630891 28666118 12932319 11756411 25907612 14530258 28289718
PPP2CA RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 18039929 7604263 16680151 16239230 10995457 18042541 18588945
PPP2CA RPS6KB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 16109716 2826472 16899564 11438723 11124802 10200280
WDR83 RAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15118098 23331499
RAF1 XIAP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16964381 19011619 25241761
STRADB XIAP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16189514 12048196
YAP1 WWTR1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 ACSN 12807903 18280240 18617895 21666501 23708000 25502501 26711338 7782338
DDB2 OGT â—¼   KO_DOWN_REGULATES ✅ - -1.02 1.01 PKG 28854368
DDB2 CDK18 â—¼   KO_UP_REGULATES ✅ + 1.16 1.16 PKG 28854368
DDB2 DDB2 â—¼   KO_DOWN_REGULATES ✅ - -5.71 5.7 PKG 28854368