Protein list:

Seperate proteins by space | Example

Select nodes using shift click or drag to add to this list
Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
Graph tools:

Note this may take some time with > 30 proteins
Filter Graph:

0.5
Layout:
  🔂

Click a node or edge for more data...
Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
ABL1 RTN4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ABL1 NCKAP5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ABL1 SF3B4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
H3-4 APAF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
ATM H2AX â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1106300109 22451927
ATM H2AX â—¼   COLOCALIZATION 2.0 0.8 intact 16858402 5218840
CAPN1 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CAPN1 MAPT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 25969760 1730702
CLU APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SF3A2 DHX9 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219711 17332742
DHX9 HNRNPK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22365833 8293266
SF1 HNRNPK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22365833 8293266
PABPC1 HNRNPK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22365833 8293266
HNRNPK DDX17 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22365833 8293266
H2AX KAT2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20224553
FSCN2 KAT5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
A2M KAT5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
H4C6 KAT5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
KAT5 TCF4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
KAT5 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
KAT5 SART3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22132941 23088399
MAPK1 L1CAM â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10608864 10818153
MAPK1 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
MAPK1 L1CAM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17151951 21080252
MAPK1 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15778365
MAPK3 MAPT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19046355 9614189
MAPT AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0709180105 18292230
GSK3B MAPT â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 17078951 5219283
MAPT CDK5 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 17078951 5219283
RAD50 NBN â—¼   COLOCALIZATION 2.0 0.8 intact 7114538 19197236
RAD50 HSPA5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
RAD50 RANBP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
RAD50 MRE11 â—¼   COLOCALIZATION 2.0 0.8 intact 7114538 19197236
SF3B3 YWHAG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
SFPQ PTBP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15975576 5217783
TP63 NOTCH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20442293 20950370
TP63 TCF4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22232078
YBX1 SF3A2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219711 17332742
GSK3B YBX1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 16198352 5217974
H3-4 YY1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H4C6 YY1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
YY1 SLC1A2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 24469401 21852380
YY1 SF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22951020
H2AX H4C6 â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 24981860
H3-4 MRE11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
SF3B2 SF3A2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219711 17332742
U2AF2 SF3A2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219711 17332742
SF3B4 SF3A2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219711 17332742
SF3B1 SF3A2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219711 17332742
WBP11 SF3A2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219711 17332742
SF3A2 RBM17 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219711 17332742
SF3A2 PQBP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219711 17332742
SF3A2 DDX17 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219711 17332742
SF3A2 DDX46 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219711 17332742
RBM17 DHX15 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22365833 8293266
DHX15 YWHAG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
DDX17 SF3B4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22365833 8293266
SF3B4 HNRNPH1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22365833 8293266
SF3B4 CHERP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22365833 8293266
SF3B4 SF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22365833 8293266
SF1 HNRNPH1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22365833 8293266
HNRNPH1 YWHAG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
SF3B1 RBM17 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22365833 8293266
RBM17 SF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22365833 8293266
NEURL1 JAG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 15380241
HRAS SF3B2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HDAC1 H4C6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10220385
APP ADAM10 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ADAM10 APP â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 20676056 10097139
YWHAG TCF4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
IGF1R YWHAG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
PKN1 AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1218925110 23223530
AKT1 KHSRP â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 17177604 19198587
MAPK8 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16306447
PTPRF AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15896785
WASF2 CYFIP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15048123 5216987
CYFIP2 CYFIP1 â—¼   COLOCALIZATION 2.0 0.8 intact 11438699 5214235
CYFIP2 WASF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15048123
ADAM17 PTPRF â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16478662
CDK5 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PPFIBP1 YWHAG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
MYCBP2 YWHAG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
YWHAG H4C6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
YWHAG FSCN2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
YWHAG PABPC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
YWHAG THRAP3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
PKN1 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RASD1 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PABPC1 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HSPA5 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SYP APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
AGER APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HSPA5 EPS15L1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
U2AF2 KHDRBS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22365833 8293266
KHDRBS1 NCKAP5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
ABI1 WASF2 â—¼   COLOCALIZATION 2.0 0.8 intact 17101133 5219329
WIPF1 WASL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218469 16582881
A2M CYFIP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
WIPF1 WAS â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 9405671 5221801
SF1 SF3A1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22365833 8293266
SF3A3 SF3A1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22365833 8293266
U2AF2 SF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
U2AF2 DDX17 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22365833 8293266
U2AF2 CPSF7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219196 17024186
SF1 U2AF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10606272 16376933
WBP11 DDX17 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
WBP11 PQBP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
RTN4 RYR3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
PTPRF H4C6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H3-4 PRKCH â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H3-4 H4C6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
H4C6 H3-4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1003064107 20498094
DDX17 DHX15 â—¼   PHYSICAL_INTERACTION 802.0 0.8 STRING 36370105
RAD50 ATM â—¼   PHYSICAL_INTERACTION ✅ + 0.8 0.8 Signor 18854157
ATM RAD50 â—¼   PHOSPHORYLATION 0.8 0.8 Signor 17570479
CCDC97 SF3B1 â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
H2AX MRE11 â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 6805208 18583988
MRE11 H2AX â—¼   COLOCALIZATION ✅ 0.81 0.81 mint 22157895 8303386
CUL4B SFPQ â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34026424 28225217
CUL4B DDX3X â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21145461 34026424
YY1 INO80 â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 24981860
MRE11 NBN â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 24981860
YLPM1 NONO â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 27609421 21988832
H2AX RAD50 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 16377563 19234442 31501894 15201865 10959836 18583988
ARF6 RPN1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 17353931
CPSF7 SFPQ â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34133714 24981860
DDX17 SFPQ â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34133714 26344197
CTBP1 H2AX â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34133714 31041561
ILF2 MRE11 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 20808282 22863883
SF3A2 CHERP â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 12234937 17332742
SF3A2 U2AF2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 12234937 17332742
SF3B4 CPSF7 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34133714 24981860
FGFR2 CHERP â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
AKT3 AKT1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
CPSF6 U2AF2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22939629 26641092
U2AF2 DDX17 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22365833 26641092
INO80 YY1 â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
KRAS MAPK1 â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
AKT1 GSK3B â—¼   DOWN_REGULATES ✅ - 0.82 0.82 Signor 15829723
AKT1 GSK3B â—¼   PHOSPHORYLATION ✅ - 0.82 0.82 Signor 23552696
ABL1 ENAH â—¼   PHYSICAL_INTERACTION 827.0 0.82 STRING 36370105
NONO U2AF2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 21566083 26641092 26344197
PYGB PYGL â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 25910212 25416956 32296183 33961781
HTATSF1 SF3B3 â—¼   PHYSICAL_INTERACTION 829.0 0.83 STRING 36370105
SFPQ U2AF2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 21566083 22939629 26641092
H2AX ILF2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 20000738 33961781 26186194
CCDC97 SF3B3 â—¼   PHYSICAL_INTERACTION 830.0 0.83 STRING 36370105
ATM NBN â—¼   PHOSPHORYLATION ✅ + 0.83 0.83 Signor 10802669
HDAC1 SFPQ â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
KAT5 APBB1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 32296183 16223726 15044485 16713569 11441186 17368826 15331662 33849647 25342469 14699153
BLM RAD50 â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
BLM H2AX â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 15364958 29523790
GSK3B SFPQ â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 20932480 30711629
RBM17 SF3B2 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
PPP1CC WBP11 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
ABI1 WASL â—¼   PHYSICAL_INTERACTION 845.0 0.84 STRING 36370105
DDX3X EIF3D â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
KRAS NRAS â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
RAD50 BLM â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 29523790 25084169 10783165
CUL4B HDAC1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 34026424 25189618
SF3B3 U2AF2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 27720643 22939629 26641092
AKT2 AKT1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 28514442 12149249 9736715 12176337 11445557 33961781 14500673 11278835 11546794
U2AF2 SF3B2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 28514442 27720643 33961781 26641092
HNRNPK KHDRBS1 â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
PYGB PYGL â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
APBB1 VASP â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 34079125 16055720
NBN BLM â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 29523790 10783165
CUL4B DHX9 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 21145461 28225217
H2AX NBN â—¼   PHYSICAL_INTERACTION ✅ 0.86 0.86 mint 6805208 18583988
H2AX NBN â—¼   COLOCALIZATION ✅ 0.86 0.86 mint 22565321 8391733
NBN H2AX â—¼   COLOCALIZATION ✅ 0.86 0.86 mint 22157895 8303386
ITPR1 AKT1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 24947355 18250332
ABI1 CYFIP2 â—¼   PHYSICAL_INTERACTION 859.0 0.86 STRING 36370105
RASD1 GNAI1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 11842095 16189514 10840027
DDX3X EIF3D â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 22863883 18628297
DDX46 SF3A1 â—¼   PHYSICAL_INTERACTION 859.0 0.86 STRING 36370105
DDX46 HTATSF1 â—¼   PHYSICAL_INTERACTION 861.0 0.86 STRING 36370105
DDX46 SF3B4 â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
DDX46 SF3B3 â—¼   PHYSICAL_INTERACTION 864.0 0.86 STRING 36370105
HDAC1 YY1 â—¼   PHYSICAL_INTERACTION 864.0 0.86 STRING 36370105
ATM H2AX â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 16858402 27918549 22184063 9488723 32518374 20081839 18344987 21676867 22451927 21704408 11571274 11893489 26095369
DHX9 ILF2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 22863883 22939629 23986595
SF3A2 SF3A3 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 12234937 24981860 17332742 22939629 26344197
SF3A2 SF3B4 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 12234937 26344197 17332742
SF3A2 DHX15 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 24304693 12234937 17332742
SF3B1 SF3B4 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28541300 12234937 22939629 26344197
YWHAG PAK4 â—¼   PHYSICAL_INTERACTION ✅ 0.87 0.87 mint 29100370
PAK4 YWHAG â—¼   PHYSICAL_INTERACTION ✅ 0.87 0.87 mint 5217174 15324660
CPSF6 CPSF7 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 26496610 33961781 24981860 22939629
APP CLU â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
ENAH VASP â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
DDX46 SF3B2 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
APBB1 KAT5 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
ENAH EVL â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
EVL VASP â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
RBM17 SF3A2 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
CPSF6 CPSF7 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
CHERP SF3A2 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
RBM17 SF3B1 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
DDX17 SF1 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
ABL1 ATM â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
HRAS NRAS â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
ABL1 ABI1 â—¼   PHOSPHORYLATION ✅ + 0.87 0.87 Signor 21320496
PQBP1 WBP11 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
ARF6 APBB1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 34079125 24056087
APBB1 TFCP2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 9685356 16189514 16713569
APBB1 ENAH â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 9407065 16055720 17686488
ATM MRE11 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10608806 10783165 15758953
MRE11 BLM â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 29523790 28506294 10783165
ENAH EVL â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 33961781 21398369 26344197
H2AX MRE11 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16377563 19234442 31501894 22157895 15201865 12419185 18583988
DHX15 RBM17 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HuRI 32296183
SF3B4 SF3B2 â—¼   PHYSICAL_INTERACTION ✅ 0.88 0.88 mint 22365833 8293266
U2AF2 SF3B1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 26641092 16713569 27720643 22939629
ATM BLM â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
HSPA4 MAPT â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
DHX15 SF3B2 â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
MAPK1 MAPK3 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
EVL APBB1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16055720 16189514 16713569 10945997
VASP EVL â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 21398369 33961781 26186194 34079125 26344197
DHX15 SF3B3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 26344197 24304693 29021621
SF3A2 DDX46 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 12234937 26344197 17332742
DHX15 SF3A3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 26344197 29021621
DHX15 SF3B1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 26344197 24304693 29021621
DHX15 SF3A1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 22939629 24304693 29021621
DDX17 HDAC1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16189514 15298701 19995069 20663877
VASP ENAH â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 21398369 33961781 26186194 34079125 26344197
VASP ABI1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 32296183 16055720 26186194 34079125
SF3A1 SF3B1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 22939629 24981860 26344197
SF3A3 SF3B1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 22939629 24981860 26344197
PPP1CC YLPM1 â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
ILF2 ZFR â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
HRAS KRAS â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
NONO SFPQ â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
DHX15 SF3A2 â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
DDX46 SF3A3 â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
ABL1 ABI1 â—¼   PHYSICAL_INTERACTION ✅ 0.9 0.9 mint 5219329 17101133
ATM ABL1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9168116 17409407 10212258 20798688 11375976 9168117
ABL1 TP63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19783996
APBB1 LRP1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 24284412 21968187 16713569 9837937
ATM NBN â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 24800743 10783165 25088203 11252893 30952868 10608806 17507690 22464731 25895060 10839545 15758953 10839544
ATM BLM â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 29523790 10783165 12034743
KAT5 ATM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16141325
ATM AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15546863 15899889
ARF6 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17363898 16452216 15210957
MAPK1 TFCP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19237534
ARF6 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17363898 16452216 15210957
MAPK3 ABI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21419341
MAPK3 TFCP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19237534
NBN H2AX â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11110662 18583988 15733840 16377563 31501894 20081839 23145133 22157895 22941933 21676867 16932743 15201865 18001825 18001824 12419185
NBN MRE11 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 30179224 11238951 17612497 22941933 23530059 15758953 11062235 10426999 19244116 10783165 18458108 21884979 22464731 33558481 24413181 26455393 12447395 12679336 28369484 22078559 34038735 22231403 12419185 22939629 34348893 17526493 12861053 17500065 12750284 9705271 28363998 30440001 24981860 19270065 12607003 15734743
SFPQ NONO â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 17452459 18042045 11259580 21988832 25959826 30445466 12403470 31815296 30725116 34017080 33961781 24981860 17507659 30021884 22939629 26344197
SFPQ PTBP1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16713569 8449401 17507659 11514619 10653975 15975576
TP63 WIPF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17521434
YY1 PAK4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22951020
HDAC1 YY1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18634613 11486036 11940654
CTBP1 HDAC1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21102443 9650586 16189514 23752268 31041561 16713569 28947780 10995736 34147029 18765668 11022042
HDAC1 CTBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9650586 16713569
AKT1 GSK3B â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19713527 8524413 23824745 16009706 29464284 20856200 19995607 16123141 20682768 27563096 14645548 15688030 22337773 11035810 17428466 18505846 15470047 14701753 16282323
PPP1CC AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 14633703
ADAM17 APP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9774383 12535668
GSK3B CDK5 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 17607942 15676027 15652488
KHSRP GSK3B â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
PRKCH GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19836308
WASL WIPF2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 32296183 16055720 33961781 23414517 22939629
CCDC88C MAPK8 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
LAMB1 UTRN â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 20625412 11430795 11430802
WBP11 PQBP1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 25416956 16713569 27314904 10593949 33961781 11054566 26344197
PTPRF PPFIBP1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 7796809 15750591 9624153
COPS2 CUL4B â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
SF3A2 U2AF2 â—¼   PHYSICAL_INTERACTION 903.0 0.9 STRING 36370105
CDK5 MAPT â—¼   PHYSICAL_INTERACTION 905.0 0.9 STRING 36370105
ABI1 CYFIP1 â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
CYFIP1 WASF2 â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
SF3B1 U2AF2 â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
ATM NBN â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
SF3A3 SF3B4 â—¼   PHYSICAL_INTERACTION 916.0 0.91 STRING 36370105
JAG1 NOTCH1 â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
H2AX KAT5 â—¼   PROTEIN_INTERACTION 0.92 0.92 HIPPIE 23777805 20224553 18406329
SF3A2 YY1 â—¼   PHYSICAL_INTERACTION 0.92 0.92 HuRI 32296183
NBN RAD50 â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
AKT1 GSK3B â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
CYFIP2 WASF2 â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
DHX15 SF3B1 â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
DHX9 PABPC1 â—¼   PHYSICAL_INTERACTION 938.0 0.93 STRING 36370105
ABI1 WASF2 â—¼   PHYSICAL_INTERACTION 938.0 0.93 STRING 36370105
SF3A2 SF3B3 â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 12234937 26344197 22939629 17332742
SF3B2 SF3B3 â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 10490618 22939629 26344197
SF3A2 SF3B1 â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 12234937 26344197 22939629 17332742
SF3A2 SF3B2 â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 12234937 22939629 17332742
ILF2 ZFR â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 28514442 33961781 26186194 26344197
DDX46 SF3B1 â—¼   PHYSICAL_INTERACTION 942.0 0.94 STRING 36370105
ABI1 ABL1 â—¼   PHYSICAL_INTERACTION 948.0 0.94 STRING 36370105
WAS WIPF1 â—¼   PHYSICAL_INTERACTION 949.0 0.95 STRING 36370105
HTATSF1 SF3A2 â—¼   PHYSICAL_INTERACTION 950.0 0.95 STRING 36370105
WASL WIPF1 â—¼   PHYSICAL_INTERACTION 950.0 0.95 STRING 36370105
WASL WIPF2 â—¼   PHYSICAL_INTERACTION 953.0 0.95 STRING 36370105
HTATSF1 SF3B1 â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
SF3A3 SF3B3 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 22939629 24981860 26344197 30021884
SF3B3 SF3B1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 21981285 12234937 11406595 28541300 24981860 10490618 22939629 26344197
ENAH ABI1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 12672821 17101133 16055720 26496610
WASF2 ABI1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 17101133 31980649 26496610 16055720 15048123 26344197
SF3B2 SF3B1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 21981285 32152280 12234937 28541300 24981860 10490618 22939629 26344197
SF3A1 SF3B2 â—¼   PHYSICAL_INTERACTION 964.0 0.96 STRING 36370105
SF3A3 SF3B2 â—¼   PHYSICAL_INTERACTION 964.0 0.96 STRING 36370105
SF3A3 SF3B1 â—¼   PHYSICAL_INTERACTION 968.0 0.96 STRING 36370105
ABL1 ABI1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 17101133 9593709 12672821 9010225 18328268 8943360 20598684 11418237
RAD50 NBN â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 30179224 12607003 12124328 11238951 17612497 22941933 23530059 24651726 15758953 11062235 10426999 10783165 22464731 19197236 12447395 12679336 26215093 22939629 34348893 17526493 17500065 9705271 16391231 30440001 24981860 26344197 15734743
DDX46 SF3A2 â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
SF3A3 SF3B3 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
SF3A1 SF3B4 â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
SF3A1 SF3B1 â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
APBB1 APP â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
SF3A1 SF3B3 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
SF3B3 SF3B4 â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
RAD50 MRE11 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 30179224 12607003 30733337 10888888 23530059 24651726 11062235 17694070 10783165 31501894 33558481 19197236 24413181 26455393 10508516 16163361 28369484 26215093 34038735 8756642 22939629 34348893 17500065 12750284 9705271 16391231 27173435 28363998 24981860 19270065 11504724 26344197 15734743
SF3A2 SF3A1 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 11533230 12234937 22365833 24981860 17332742 30021884 22939629 26344197
SF3B4 SF3B2 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 32296183 16189514 25416956 25737013 22365833 7958871 24981860 16923959 10490618 22939629
WASL WIPF1 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 12437929 28514442 25416956 16582881 11331876 16055720 33961781 12372256 23414517 10087612
SF3A3 SF3A1 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 28514442 8022796 16189514 11533230 22365833 17098193 33961781 24981860 30021884 22939629 26344197
SF3A2 SF3B4 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
SF3B1 SF3B4 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
SF3A2 SF3B1 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
GSK3B MAPT â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
SF3A2 SF3B3 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
SF3B2 SF3B3 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
SF3B1 SF3B3 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
SF3A2 SF3A3 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
SF3A2 SF3B2 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
SF3B2 SF3B4 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
SF3B1 SF3B2 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
SF1 U2AF2 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
SF3A1 SF3A2 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
SF3A1 SF3A3 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ATM ABL1 â—¼   ENZYMATIC_REACTION ✅ 54.0 1.0 ACSN 11331603 11438669 11804596 11877377 12086603 12556884 12607003 14988723 15136767 15140942 15175241 15459660 15485915 15798197 15867354 15964794 16163361 16332722 16581787 16713580 16731533 16805667 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17713585 18006705 18048416 18469862 18511906 18583988 18716619 18756267 18995830 19151707 19282663 19342888 19357644 19490890 19622404 19788416 19793801 19793861 19841479 20019063 20051983 21376743 23847781 9168117 9858600
ATM ABL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 44.0 1.0 Omnipath 17145710 17303408 22334513 11375976 11804596 23331499 21071413 16163361 17570479 18988627 9168116 23847781 9168117 20798688 15964794 19788416 9561848 22084676 12607003 10212258 15459660 11877377 15686624 17409407
ABL1 WASF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 17101133 15657136 21419341 23354023 20841568 22448228 20533885 16899465
ABL1 CDK5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 19901323 26944284 15689152 19690332 16497976 24975575 19413330 20841568 18083107 19534553 20068231 19700222 9038181 14757045 23348931 11113134 10896159 18691976 28646794 29063113 24600352 12372285 19369195 18794154 15212693
ABL1 APP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11279131 20841568
ABL1 ENAH â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17101133 20841568 12672821
ABL1 ABI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 48.0 1.0 Omnipath 17145710 20598684 18328268 12591740 9593709 20841568 18083107 7590237 11418237 12672821 17389395 19534553 8943360 17101133 9010225 11163214 26428302 21320496
ABL1 WASL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 17389395 19901323 16199863 19664994 20068231 18707149 18452278 20146487 20841568 19415658
ABL1 APBB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 20110615 15031292 18922798 26255939 11279131 22506131 20841568
MAPK1 APBB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 14697653
H2AX ATM â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11934988 15279782 12792649 11893489 10959836
BLM ATM â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
H4C6 ATM â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11934988 15279782 12792649 11893489 10959836
ATM H3-4 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11934988 15279782 12792649 11893489 10959836
ATM RAD50 â—¼   PHYSICAL_INTERACTION 100.0 1.0 ACSN 11283614 11331603 11850621 11877377 12086603 12202749 12556884 12607003 14614141 14988723 15136767 15140942 15175241 15211575 15242590 15279786 15375219 15377654 15385537 15459660 15485915 15496928 15498778 15549137 15655342 15798197 15964794 16163361 16332722 16449207 16531125 16713580 16805667 16818604 16858402 17055429 17102137 17116323 17116885 17296725 17303408 17384638 17582221 17660363 17965729 18001825 18006705 18087292 18171670 18171986 18212739 18398454 18469862 18524993 18543256 18558713 18583988 18584027 18590585 18678890 18809224 18995830 19151707 19202191 19217833 19270065 19282663 19342888 19362533 19490890 19622404 19654615 19686080 19772495 19793801 19892829 20021983 20027199 20051983 20064462 20691907 20713526 20723763 21376743 2191300 22657828 22743550 23082994 23161013 23253856 23847781 24036544 24050180 24089143 24095737 24709898 7575488 9407949 9488723 9721205
ATM RAD50 â—¼   SHARES_COMPLEX 100.0 1.0 ACSN 11283614 11331603 11850621 11877377 12086603 12202749 12556884 12607003 14614141 14988723 15136767 15140942 15175241 15211575 15242590 15279786 15375219 15377654 15385537 15459660 15485915 15496928 15498778 15549137 15655342 15798197 15964794 16163361 16332722 16449207 16531125 16713580 16805667 16818604 16858402 17055429 17102137 17116323 17116885 17296725 17303408 17384638 17582221 17660363 17965729 18001825 18006705 18087292 18171670 18171986 18212739 18398454 18469862 18524993 18543256 18558713 18583988 18584027 18590585 18678890 18809224 18995830 19151707 19202191 19217833 19270065 19282663 19342888 19362533 19490890 19622404 19654615 19686080 19772495 19793801 19892829 20021983 20027199 20051983 20064462 20691907 20713526 20723763 21376743 2191300 22657828 22743550 23082994 23161013 23253856 23847781 24036544 24050180 24089143 24095737 24709898 7575488 9407949 9488723 9721205
CDK5 ATM â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 12556884 16332722 16858402 17303408 19151707 20724832 21727086 21922195 23589330 23850759
ATM RAD50 â—¼   REGULATES ✅ 100.0 1.0 ACSN 11283614 11331603 11850621 11877377 12086603 12202749 12556884 12607003 14614141 14988723 15136767 15140942 15175241 15211575 15242590 15279786 15375219 15377654 15385537 15459660 15485915 15496928 15498778 15549137 15655342 15798197 15964794 16163361 16332722 16449207 16531125 16713580 16805667 16818604 16858402 17055429 17102137 17116323 17116885 17296725 17303408 17384638 17582221 17660363 17965729 18001825 18006705 18087292 18171670 18171986 18212739 18398454 18469862 18524993 18543256 18558713 18583988 18584027 18590585 18678890 18809224 18995830 19151707 19202191 19217833 19270065 19282663 19342888 19362533 19490890 19622404 19654615 19686080 19772495 19793801 19892829 20021983 20027199 20051983 20064462 20691907 20713526 20723763 21376743 2191300 22657828 22743550 23082994 23161013 23253856 23847781 24036544 24050180 24089143 24095737 24709898 7575488 9407949 9488723 9721205
CDK5 ATM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 17303408 23589330 16858402 19151707 27470939 16332722 12556884 21600237 21922195
ATM TP63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 24366874 20023394 18769144
ATM FANCI â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 17412408 17525332 28636932 32117957
ATM NBN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 80.0 1.0 Omnipath 12433983 12861053 17485521 23146902 10839545 19413330 15302935 27602502 17429352 19523210 24360018 20068231 17507690 17570479 10608806 12598907 18669648 25088203 18003706 11252893 17431132 23097684 10766245 12814430 10802669 21664921 26512707 10839544 11927276 21130714 17525332 12447395 14707289 15733840 15279770 25119968 18644472 28822740
ATM BLM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 16199871 11146546 25766002 17984114 14643436 20719863 17363339 14729972 18054789 12034743 30496191 16880735 11375976
ATM MRE11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 19709933 26240375 17570479 31353207 10608806
ATM KHSRP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17525332 21329876
ATM H2AX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 197.0 1.0 Omnipath 27410735 28544233 16426903 28797244 9488723 23847653 30197789 21930799 18158901 21693595 18848500 22819196 15603757 16760673 17570479 24688021 24793032 27458206 16531125 22028490 30154456 19230794 23202908 25852739 19059218 26073471 22247744 28259974 29584802 25691887 19049966 20368801 26700820 29386061 28124509 20613862 27550454 20847938 27388041 27752097 23269287 24480460 22237206 20461094 20971043 26941327 18285803 21690091 15279774 23891287 25847270 24490130 25349305 26906421 20637859 26314960 15286739 27780918 20454618 30013081 28671946 25218945 23742011 26391293 23972723 23382699 26416514 27442013 20703100 24726884 26512707 27332952 29641431 25287622 26295265 14643438 29163809 25264544 19895790 26504743 26113859 27431324 28790385 18413980 21283714 21787120 20205745 19781914 25093845 27135971 23227178 22224778 20923785 20860841 24244154 23386996 30065307 16858402 11879731 28009280 23343929 20192759 22761798 26855420 24378750 20068231 20580718 14504478 24893124 29048667 25661368 26860083 26019182 20488183 28764946 22205726 23977391 18471973 19591958 28239143 20542002 17525332 20495376 18755145 23050241 17782711 11571274 19473884 28431265 25742493 18248856 17690115 20684759 26317467 21727091 24651472 25827888 27164092 28587922 20976184 30723510 20471486 23772364 29794999 11893489 19014481 20165693 26671524 16997395 20936109 26114388 23845989 15138496 22761813 23355489 27455285 28943310 21348461 19647519 23678292 23166506 28099474 29434792 25249630 25269479 27310012 15177039 22559321 26045162 20865059 22972376 21148072 26760771 21188122 22962268 22768044 26711340 20460517 27845910 28855246
ATM RAD50 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17570479 17081983 15302935
MRE11 BLM â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
NBN BLM â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
BLM KAT5 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
BLM FANCI â—¼   ENZYMATIC_REACTION ✅ 35.0 1.0 ACSN 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 8020957
BLM RAD50 â—¼   UP_REGULATES ✅ + 35.0 1.0 ACSN 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 8020957
DIAPH1 EVL â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 12805219 18001770 12732141 12429848 18923426
PAK4 FH â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 30683654
MAPK8 HNRNPK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11259409 11231586
MAPK3 HNRNPK â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 11259409 16564677 11231586
HNRNPK KHDRBS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 21988832 22365833 31413325 16713569 12370808
H3-4 KAT5 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11934988 15279782 12792649 11893489 10959836
GSK3B KAT5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22539723 17570479 21658600
KAT5 H4C6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12776177 10096020 32814053 24525235 16844118
KAT5 APP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 21832049 12032152 16223726 14699153 15331662 15044485
A2M LRP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 10652313 1702392 12194978 19026743
NRAS MAPK1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
HRAS MAPK1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
FGFR4 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
FGFR2 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
MAPK1 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12975377 23602568 16424009 19058874 23397142 21707490
MAPK1 MAPT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 67.0 1.0 Omnipath 9614189 9832145 12387894 12766916 12765608 12414518 19413330 1330687 24116116 19415658 15302935 33961674 9716264 34493616 31178717 28066266 15324364 31065832 25573097 12801934 29298849 16165272 15883264 16115884 8166686 33952699 9565682 11181841 34536819 10737616 7566346 18315566 9771888 29760653 34480088 24301651 15542598 18055457 12226093 7488031 9199504 18510355 21731772
MAPK1 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 16039586 28646232 18451303
MAPK1 ABI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 19917258 17855441 21419341 21900237
MAPK1 KHDRBS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 18691976 12478298 19664995 20068231
KRAS MAPK3 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
NRAS MAPK3 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
HRAS MAPK3 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
FGFR4 MAPK3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
FGFR2 MAPK3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
MAPK3 ADAM17 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12058067 18187448 21570469
MAPK3 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 16039586 28646232
MAPK8 MAPT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 34342183 17314187 33557920 15312816 17761554 33762974 33842885 12614922 15136685 17270732 15228592 28758999 34385305 8506352 15994305
PKN1 MAPT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 46.0 1.0 Omnipath 9565682 11181841 9614189 9832145 11104762 12387894 12226093 19562805 12714590 19857203 12435421 9546672 9771888 19413330 9199504 8999860
CDK5 MAPT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 103.0 1.0 Omnipath 16697218 26944284 21945393 9614189 7592534 9832145 19562805 12387894 21848865 27641626 24268883 9546672 12071639 19413330 1330687 19415658 15302935 9353289 21671254 20508838 8282104 20068231 26998748 16568235 21215781 17045592 9565682 11181841 7566346 12435421 17287340 9771888 15843619 17078951 22761989 24367683 19651622 1181841 9735171 11104762 12226093 9199504 18510355 11311121 2387894 28785087
GSK3B MAPT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 141.0 1.0 Omnipath 19616957 22278060 25641096 9832145 19562805 12387894 24268883 9546672 31640277 21865886 19413330 28386764 28379300 1330687 28734998 19415658 15302935 17047304 7706316 27349344 29408874 9716264 9353289 21671254 24165324 12714590 20068231 12387897 17570479 16452634 25815351 21215781 16568235 16519507 8999860 17045592 9565682 27857758 11181841 14690523 22690349 27073700 21443865 10601262 7566346 10737616 15522877 12435421 17287340 9771888 29725295 15073173 17078951 19651622 1181841 15542598 9735171 12226093 11104762 21985244 20049527 28835279 27965573 20679343 20308788 9199504 18510355 10090741 11311121 2387894
NBN H4C6 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11934988 15279782 12792649 11893489 10959836
NBN H3-4 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11934988 15279782 12792649 11893489 10959836
MRE11 NBN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 17145710 22464731 26455393 12861053 17500065 15734743 12419185 19270065 22078559 19244116 21884979 12679336 11238951 12607003 9705271 17713585 10783165 12447395 10426999 18458108 15758953
SFPQ NONO â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 17452459 21988832 17145710 17507659 12403470 11259580 30021884 10858305 18042045 20421735 25959826
H3-4 RAD50 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11934988 15279782 12792649 11893489 10959836
H4C6 RAD50 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11934988 15279782 12792649 11893489 10959836
RAD50 MRE11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19197236 16163361 10888888 8756642 17713585
GSK3B SFPQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20932480
TP63 JAG1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23863842 11641404 23837456
AKT1 YBX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 17081983 32028981 33911076 26318844 33151228 20844753 27591085 17704806 21423216 19036157 31906126 15806160 24335958 34272387 33379356 19651622 31387591 16354698 19664994
YY1 HSPA5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16452489 15899857 15760841 8972185
YY1 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 16713569 12913000
MAPK8 H2AX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 22972376 16818236 19234442 17211821
MRE11 H3-4 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11934988 15279782 12792649 11893489 10959836
MRE11 H4C6 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11934988 15279782 12792649 11893489 10959836
MYH9 WIPF1 â—¼   PHYSICAL_INTERACTION 20.0 1.0 ACSN 10467124 10511705 11395419 11520460 12177428 14707117 15001467 16293614 16606694 17890224 19349987 19741094 21178402 21840487 22166994 23212475 23725295 24857661 25712372 8625410
MYH9 WIPF1 â—¼   SHARES_COMPLEX 20.0 1.0 ACSN 10467124 10511705 11395419 11520460 12177428 14707117 15001467 16293614 16606694 17890224 19349987 19741094 21178402 21840487 22166994 23212475 23725295 24857661 25712372 8625410
NOTCH1 JAG1 â—¼   PHYSICAL_INTERACTION 21.0 1.0 ACSN 11955436 11967263 12051714 15001769 16039586 17143292 17936032 19567869 19619488 20351093 20705860 20940030 21841793 22330899 22363130 22363487 23343194 24023259 25730849 7542250 8666229
NOTCH1 JAG1 â—¼   SHARES_COMPLEX 21.0 1.0 ACSN 11955436 11967263 12051714 15001769 16039586 17143292 17936032 19567869 19619488 20351093 20705860 20940030 21841793 22330899 22363130 22363487 23343194 24023259 25730849 7542250 8666229
ADAM10 NOTCH1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 18676862 19601831 19704010 19726682 22006996
ADAM17 NOTCH1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 18676862 19601831 19704010 19726682 22006996
NOTCH1 JAG1 â—¼   LOCALISATION ✅ 21.0 1.0 ACSN 11955436 11967263 12051714 15001769 16039586 17143292 17936032 19567869 19619488 20351093 20705860 20940030 21841793 22330899 22363130 22363487 23343194 24023259 25730849 7542250 8666229
ADAM10 NOTCH1 â—¼   CLEAVAGE ✅ 5.0 1.0 Reactome 9244301 12354787 17401372 10882063 19726682
ADAM10 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 19726682 28624438 19704010 19601831 22399336
GSK3B NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 16944320 15465828 12123574 11967263 14663202 8524413 21828089 16713569 9832503 15020233
ADAM17 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 10882063 19726682 19704010 19601831 9620803
JAG1 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 39.0 1.0 Omnipath 18495817 16921404 15137944 769772111006133 16713569 23331499 21071413 23086448 22363130 18988627 21820430 18292500 18660822 22330899 17537801 11006133 7697721 10958687 22353464
ADAM10 JAG1 â—¼   CLEAVAGE ✅ 5.0 1.0 Reactome 9244301 12354787 17401372 10882063 19726682
HRAS FGFR4 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
HRAS MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 11525649 8137421 16810318 16713569
ADAM10 ADAM17 â—¼   PHYSICAL_INTERACTION 5.0 1.0 ACSN 18676862 19601831 19704010 19726682 22006996
ADAM10 ADAM17 â—¼   PROTEIN_INTERACTION 5.0 1.0 ACSN 18676862 19601831 19704010 19726682 22006996
ADAM10 APP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 32814053 30538620 12535668
IGF1R YWHAG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 12767520 10826997 12444011 21540285 17145710 17353931 19030972 16931767 15324660 12175651
AKT1 KHSRP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 17177604 19198587
AKT1 ITPR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 24947355 18250332 16332683 18955969
AKT1 WNK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 21355052 16081417 14611643 22119528
AKT1 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 99.0 1.0 Omnipath 17428466 15207235 17145710 12052830 10729337 8250835 11756412 11923280 16914735 17623045 16697215 8524413 12054501 20398329 18372248 21506126 20028971 12040186 15808505 16543730 20138985 23331499 21303971 16009706 10385618 20214616 23180781 9373175 16039586 15829723 18988627 16282323 11577096 11035810 18669648 18216173 15169778 12851486 16123141 11882383 23109003 9065430 18691976 22094462 10949026 22710759 11715018 12459251 18636226 17192257 11254732 11278246 20858269 9812896 9582355 15023346 17680028 19369195 7945242 12900420 23552696 18387957 10722653 20832730 18570873 12147701 18505846 17052453 17693255 18218901
AKT1 AKT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 11546794 14500673 12176337 11445557 9736715 12149249 11278835
AKT1 YWHAG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 20138985 15169778 9812896 17680028 11756412 11923280 20214616 16697215 10949026 10722653 20832730 18570873 18372248 11715018 20398329 17052453 18636226 15808505
CDK5 APP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 18833287 15178331 15917097 11877420 17085446 16554819 21947912 8131745 11517218 17459339 14970211 10341243 16705182 24610780 22112898 8764598 14557249 16223726 19455415 19090995 10936190 11146006 15944381
MAPK8 APP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 12917434 14970211 24610780 20122754 15936948
DDX3X PABPC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18596238 21883093 22872150
AKT3 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 12851486 15023346 21303971 11882383 17680028 9065430 23109003 20214616 22094462 23552696 20398329 21506126 20028971 12040186 18218901
AKT2 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 17145710 21303971 11882383 17680028 9065430 20214616 22094462 23552696 12434148 20398329 21506126 26051358 16293724 20028971 12040186 9712142 18218901
WIPF1 WASL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 16582881 10087612 16055720 12372256 10878810 11331876 25416956 23414517 12437929
MAPK8 CTBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 28532298 14567915 17496919 19591900 21372320 19788416 15708980 8608010 16984892 20512932 20220133 21438496 20054826 19616017 23762064 15611655
KRAS FGFR4 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
NRAS FGFR4 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
AKT2 KHSRP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17177604