CHEK2
|
ATM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
19001859
12364621
|
MDM4
|
ATM
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
15788536
16163388
|
MDM2
|
ATM
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
19816404
21986495
|
CHEK2
|
ATM
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
16651405
10724175
|
FOXO3
|
ATM
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18344987
18424439
|
E2F3
|
ATM
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18469863
12527885
|
DCLRE1B
|
ATM
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19411856
|
E2F3
|
ATM
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
12527885
18319725
|
E2F4
|
ATM
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
18319725
16135806
|
ATM
|
HERC2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20023648
|
NBN
|
ATR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
12791985
16327781
|
MRE11
|
ATR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
12791985
16327781
|
CHEK1
|
ATR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
0706013104
17686975
|
BLM
|
ATR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
12791985
16327781
|
BRCA1
|
ATR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
12791985
16327781
|
ATRIP
|
ATR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
0706013104
17686975
|
ATR
|
RBBP8
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
12791985
16327781
|
ATR
|
BRIP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
12791985
16327781
|
ATR
|
BARD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
12791985
16327781
|
ATR
|
KAT5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
12791985
16327781
|
TP53
|
ATR
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
9925639
10435622
|
ATR
|
BRCA1
|
â—¼ PHOSPHORYLATION
|
✅
|
+
|
0.8
|
0.8
|
Signor
|
23422745
|
DCLRE1B
|
ATR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19411856
|
ATR
|
HERC2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20023648
|
ATR
|
RAD1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16436514
|
BLM
|
ATRIP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
12791985
16327781
|
BRCA1
|
ATRIP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
12791985
16327781
|
NBN
|
ATRIP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
12791985
16327781
|
MRE11
|
ATRIP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
12791985
16327781
|
ATRIP
|
BARD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
12791985
16327781
|
ATRIP
|
KAT5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
12791985
16327781
|
ATRIP
|
RBBP8
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
12791985
16327781
|
ATRIP
|
BRIP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
12791985
16327781
|
TP53
|
ATRIP
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
9925639
10435622
|
CHEK1
|
ATRIP
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
20639859
8010047
|
ATRIP
|
TOPBP1
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
8086392
20871591
|
XRCC5
|
ATRIP
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18285803
|
ATRX
|
POT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
20211137
20651253
|
BRCC3
|
BRCA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
19202061
0807485106
|
BRCA2
|
BRCA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
19369211
0811159106
|
TP53BP1
|
BRCA1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15970701
21914189
|
EP300
|
BRCA1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23353771
23285190
|
PIAS4
|
BRCA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
21113239
|
TP53
|
BRCA2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
1003689107
20421506
|
NCL
|
BRCA2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
000924
30021884
|
BRCA2
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17474147
8109998
|
FOXM1
|
BRCA2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20068070
17101782
|
FOXM1
|
BRCA2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17101782
|
PALB2
|
BRIP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
19369211
0811159106
|
FOXM1
|
BRIP1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23108394
|
CCND1
|
RBL2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
11157749
9144196
|
CCND1
|
E2F5
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
11157749
9144196
|
STAT3
|
CCND1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11279133
|
CCND1
|
STAT3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
11279133
|
FOXM1
|
CDC25A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23240008
|
CDC25A
|
CHEK2
|
â—¼ PHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
intact
|
11298456
5213933
|
BTRC
|
CDC25A
|
â—¼ UBIQUITINATION
|
✅
|
|
2.0
|
0.8
|
intact
|
14603323
5216801
|
E2F3
|
CDC25A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
15210709
18319725
|
E2F1
|
CDC25A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15210709
18319725
|
MAPK14
|
CDC25A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
19289404
|
E2F4
|
CDC25A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11799067
18319725
|
CDC25A
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
15672448
|
E2F3
|
CDK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
8033208
7958856
|
HRAS
|
CDK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NBN
|
CDK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
25558984
22231403
|
CDK2
|
MRE11
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
25558984
22231403
|
CDK2
|
RBBP8
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
25558984
22231403
|
CDK2
|
KAT5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
25558984
22231403
|
CDK2
|
MCM5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
10523313
10373557
|
SKP2
|
CDKN1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16376880
5218183
|
CCNB2
|
CDKN1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
15232106
5217098
|
CDKN1A
|
RBL2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
11157749
9144196
|
CDKN1A
|
E2F5
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
11157749
9144196
|
HNF4A
|
CDKN1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17885207
|
CDKN1A
|
TP53
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
16616141
5218511
|
CCNA1
|
CDKN1A
|
â—¼ PROXIMITY
|
|
|
2.0
|
0.8
|
intact
|
29997244
20178071
|
E2F3
|
CDKN1A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
10030670
18319725
|
PPARG
|
CDKN1A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15041706
|
CDKN1A
|
FEN1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
17129767
|
MCM5
|
CDKN2A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
15232106
5217098
|
CDKN2A
|
CDK6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
15232106
5217098
|
NSD2
|
CDKN2A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19340300
|
E2F4
|
CDKN2A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
12766778
18319725
|
CDKN2A
|
KAT5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
16915296
|
E2F4
|
CHEK1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17531812
|
CHEK1
|
MDM4
|
â—¼ PHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
intact
|
5218401
16511572
|
CHEK1
|
TP53
|
â—¼ PHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
intact
|
5218401
16511572
|
E2F4
|
CHEK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11799067
18319725
|
NBN
|
CHEK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
19001859
12364621
|
RNF8
|
CHEK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
19001859
12364621
|
HERC2
|
CHEK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
19001859
12364621
|
CHEK2
|
PIAS4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
19001859
12364621
|
CHEK2
|
UBE2V2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
19001859
12364621
|
CHEK2
|
UBE2N
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
19001859
12364621
|
CHEK2
|
NSD2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
19001859
12364621
|
CHEK2
|
MRE11
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
19001859
12364621
|
CHEK2
|
RNF168
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
19001859
12364621
|
CHEK2
|
KAT5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
19001859
12364621
|
RNF8
|
CHEK2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
16651405
10724175
|
HERC2
|
CHEK2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
16651405
10724175
|
NBN
|
CHEK2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
16651405
10724175
|
CHEK2
|
KAT5
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
16651405
10724175
|
CHEK2
|
NSD2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
16651405
10724175
|
CHEK2
|
UBE2V2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
16651405
10724175
|
CHEK2
|
RNF168
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
16651405
10724175
|
CHEK2
|
UBE2N
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
16651405
10724175
|
CHEK2
|
MDC1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
16651405
10724175
|
CHEK2
|
RAD50
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
16651405
10724175
|
CHEK2
|
PIAS4
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
16651405
10724175
|
CHEK2
|
MRE11
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
16651405
10724175
|
CHEK2
|
TP53BP1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
16651405
10724175
|
CHEK2
|
MDM2
|
â—¼ PHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
intact
|
15862297
5217705
|
E2F4
|
CHEK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18319725
12909625
|
RNF168
|
DCLRE1C
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
25512557
15574327
|
RNF8
|
DCLRE1C
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
25512557
15574327
|
UBE2N
|
DCLRE1C
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
25512557
15574327
|
RAD50
|
DCLRE1C
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
25512557
15574327
|
PAXIP1
|
DCLRE1C
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
25512557
15574327
|
MRE11
|
DCLRE1C
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
25512557
15574327
|
NBN
|
DCLRE1C
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
25512557
15574327
|
UBE2V2
|
DCLRE1C
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
25512557
15574327
|
TP53BP1
|
DCLRE1C
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
25512557
15574327
|
MDC1
|
DCLRE1C
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
25512557
15574327
|
HERC2
|
DCLRE1C
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
25512557
15574327
|
KAT5
|
DCLRE1C
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
25512557
15574327
|
NSD2
|
DCLRE1C
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
25512557
15574327
|
PIAS4
|
DCLRE1C
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
25512557
15574327
|
DCLRE1C
|
XRCC4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16857680
|
E2F2
|
E2F1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
7958836
|
E2F1
|
MCM8
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16325355
|
E2F1
|
MAPK8
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20800677
|
E2F1
|
MYH10
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
8931991
|
E2F1
|
MCM5
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11799067
17210690
|
E2F1
|
MAPK1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18396012
|
MAPK3
|
E2F1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
14967450
22802261
|
E2F1
|
RBBP8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18319725
12909625
|
E2F1
|
E2F2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15014447
18319725
|
E2F1
|
XRCC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18348985
|
E2F1
|
AURKB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18319725
15033491
|
STAT3
|
EME1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20516069
18245483
|
EP300
|
CDKN2B
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
22000024
19419955
|
NBN
|
EP300
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
21108945
8058069
|
MAPK3
|
EP300
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
24530506
|
EP300
|
FOXO3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
11896584
|
EP300
|
RECQL4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
19299466
|
ERCC6
|
MAPK8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16319174
|
E2F4
|
FEN1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17531812
|
FEN1
|
MUS81
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
22551069
8372920
|
RECQL4
|
FEN1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19567405
|
E2F4
|
FOXM1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17531812
|
FOXM1
|
XRCC1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20068070
17101782
|
FOXM1
|
XRCC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17101782
|
FOXO3
|
CCND2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
12391153
15509806
|
FOXO3
|
PIK3R1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19056725
21752881
|
FOXO3
|
CDKN2B
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19419955
17873901
|
FOXO3
|
SIRT1
|
â—¼ DEACETYLATION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
14976264
23665396
|
FOXO3
|
RBL2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11884591
|
SPTA1
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
12700044
2809592
|
GRB2
|
NCL
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5216105
12577067
|
GRB2
|
PPP1CB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5216105
12577067
|
GRB2
|
NONO
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5216105
12577067
|
GRB2
|
DLST
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5216105
12577067
|
GRB2
|
PRKDC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5216105
12577067
|
GRB2
|
ILF3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5216105
12577067
|
GRB2
|
LMNA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5216105
12577067
|
GRB2
|
DYNLL1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5216105
12577067
|
GRB2
|
ITPR3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5216105
12577067
|
GRB2
|
XRCC6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5216105
12577067
|
GRB2
|
PPP3CA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5216105
12577067
|
GRB2
|
MYH10
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5216105
12577067
|
GRB2
|
H3C2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5216105
12577067
|
MAPK3
|
GRB2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
7739560
8816480
|
MAPK1
|
GRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
8994038
|
RNF8
|
HERC2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
20016603
20023648
|
PRKDC
|
HERC2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20023648
|
TP53
|
HMGB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
6547598
9472015
|
E2F4
|
HMGB1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17531812
|
KAT5
|
LMNA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16169070
5217955
|
KAT5
|
BARD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
15383276
5217202
|
KAT5
|
GADD45G
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
15383276
5217202
|
SIRT1
|
KAT5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
20100829
|
KAT5
|
H3C2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
10096020
|
LIG3
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17474147
8109998
|
MAPK14
|
MAP2K6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17255949
5219578
|
MAPKAPK2
|
MAP2K6
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
8622669
7535770
|
MAP2K6
|
MAPK14
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
8622669
7535770
|
LRRK2
|
MAP2K6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19302196
|
MAP2K6
|
MAPK8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11460167
10882101
|
MAPK1
|
MAP2K3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23331499
16709866
|
MAPK1
|
MAPK8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
15778365
|
MAP2K3
|
MAPK14
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
8622669
7535770
|
TP53
|
MAPK3
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
21187340
16050810
|
MAP2K3
|
MAPKAPK2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
8622669
7535770
|
ETS1
|
MDM2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
11424091
|
MDM2
|
MDM4
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
17159902
5219425
|
PPP1CB
|
MDM2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23277204
|
PPP1CC
|
MDM2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23277204
|
MDM4
|
TP53
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
19521340
7290688
|
TRIM29
|
MLH1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16189514
5217968
|
E2F4
|
MLH1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17531812
|
TP53
|
MLH1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15781865
|
E2F4
|
MLH1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11799067
18319725
|
MSH6
|
MSH2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
6548274
9774676
|
MYC
|
MSH2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
12808131
11983916
|
TP53
|
MSH2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
12209975
|
E2F4
|
MSH2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11799067
18319725
|
MTOR
|
EIF4EBP1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
12150926
15809305
|
E2F5
|
MYC
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
17132729
|
MYC
|
PIK3R1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19602047
11509615
|
MYC
|
HLA-F
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
8206526
|
E2F2
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11564866
18319725
|
E2F3
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11564866
18319725
|
STAT3
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
22943793
15810077
|
E2F5
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
12150994
18319725
|
RAD50
|
NBN
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
7114538
19197236
|
NPM1
|
AIM2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
000924
30021884
|
TP53
|
PAXIP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
19433796
0902873106
|
XRCC6
|
PIAS4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
7986053
19779455
|
XRCC5
|
PIAS4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
7986053
19779455
|
PIAS4
|
GADD45G
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
15383276
5217202
|
PIAS4
|
DLST
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
PIAS4
|
BARD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
15383276
5217202
|
MAPK8
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
7033842
16982329
|
LRRK2
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
29513927
201700444
|
PIK3R1
|
MAPK8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
7642542
16982329
|
PIK3R1
|
STAT3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
25814554
15021914
|
POLL
|
XRCC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
18971944
7294748
|
HRAS
|
PPP5C
|
â—¼ DEPHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
16892053
21779496
|
NRAS
|
PPP5C
|
â—¼ DEPHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
16892053
21779496
|
KRAS
|
PPP5C
|
â—¼ DEPHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
16892053
21779496
|
PPP5C
|
TP53BP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
19176521
|
H3C2
|
PRKDC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
20080577
0913709107
|
PRKDC
|
RNF8
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
000924
30021884
|
E2F4
|
PRKDC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18319725
16135806
|
RAD50
|
MRE11
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
7114538
19197236
|
MRE11
|
RBBP8
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
21052091
8081463
|
E2F4
|
RBBP8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18319725
12909625
|
E2F4
|
RFC4
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17531812
|
XRCC6
|
RINT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
000924
30021884
|
RNF8
|
RNF168
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20385750
|
H3C2
|
SIRT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
18485871
23897426
|
H3C2
|
SIRT1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
15469825
18485871
|
SIRT1
|
H3C2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
19270680
|
CEP43
|
STAT3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
10918587
11689702
|
TOPBP1
|
TP53BP1
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
8086392
20871591
|
TP53
|
E2F4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
15574328
24096481
|
TP53
|
BTRC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
19196987
0812256106
|
TP53
|
NCL
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
22103682
8291914
|
TP53
|
H3C2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16980608
|
TP53
|
TRRAP
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
12138177
11779500
|
TP53
|
ZDHHC5
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
28775165
|
TP53
|
E2F3
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
20428827
|
TP53
|
DLST
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17916908
21191025
|
TP53
|
KDM4B
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
28073943
|
USP7
|
TP53
|
â—¼ DEUBIQUITINATION
|
✅
|
|
2.0
|
0.8
|
intact
|
5215220
11923872
|
DAXX
|
TP53
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
14557665
5216762
|
PIK3R3
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
32606738
|
TP53
|
DDR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18431400
|
TP53
|
RECQL4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
15674334
|
TP53
|
BARD1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
14636569
15782130
|
TP53
|
HRAS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18431400
|
TERF2
|
TP53BP1
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
21824286
8202878
|
ACD
|
USP7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16713569
5218676
|
USP7
|
DAXX
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.8
|
0.8
|
mint
|
6799761
18566590
|
H3C2
|
XRCC5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
20080577
0913709107
|
H3C2
|
XRCC6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
20080577
0913709107
|
XRCC6
|
ACD
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16169070
5217955
|
E2F4
|
BARD1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17531812
|
E2F4
|
BARD1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11799067
18319725
|
NCL
|
PPP1CB
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
12185196
8262810
|
CDK6
|
E2F5
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
11157749
9144196
|
CDK6
|
RBL2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
11157749
9144196
|
CALM2
|
ITPR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
7755592
10456332
|
LRRK2
|
E2F4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
29513927
201700444
|
LIN9
|
E2F4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5219419
17159899
|
E2F4
|
LIN54
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19725879
|
E2F4
|
H3C2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11799066
|
E2F4
|
CCNB2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
12771133
17531812
|
E2F4
|
E2F3
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17531812
|
E2F4
|
BTRC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15782160
18319725
|
E2F4
|
AURKB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18319725
15033491
|
E2F4
|
CCNB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15574595
18319725
|
E2F4
|
MCM5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11799067
18319725
|
TINF2
|
TERF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
11701125
5214767
|
POT1
|
DAXX
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
20211137
20651253
|
TERF2
|
ACD
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
0605303103
16880378
|
LRRK2
|
AURKB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
29513927
201700444
|
E2F3
|
PPARG
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
12110166
18319725
|
LRRK2
|
MAP2K3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19302196
|
HDAC5
|
GATA3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
0607926103
17075044
|
CCND2
|
E2F5
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
11157749
9144196
|
CCND2
|
RBL2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
11157749
9144196
|
RBL2
|
CCNA2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
8253383
18319725
|
E2F2
|
CCNA2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15510213
18319725
|
E2F3
|
CCNB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15574595
18319725
|
MAP2K2
|
MAPK6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18039929
|
HSF2
|
MAPK8
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
11557063
|
E2F3
|
MCM5
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
10327050
|
TERF2IP
|
TERF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
0605303103
16880378
|
TERF1
|
ACD
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
0605303103
16880378
|
MAPK14
|
MAPKAPK2
|
â—¼ PHOSPHORYLATION
|
✅
|
+
|
0.8
|
0.8
|
Signor
|
14499342
|
ATM
|
RBBP8
|
â—¼ PHOSPHORYLATION
|
✅
|
-
|
0.8
|
0.8
|
Signor
|
10910365
|
RAD50
|
ATM
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
+
|
0.8
|
0.8
|
Signor
|
18854157
|
ATM
|
RAD50
|
â—¼ PHOSPHORYLATION
|
|
|
0.8
|
0.8
|
Signor
|
17570479
|
ATM
|
CHEK2
|
â—¼ PHOSPHORYLATION
|
✅
|
+
|
0.8
|
0.8
|
Signor
|
10973490
|
RAD50
|
BRCA1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
+
|
0.8
|
0.8
|
Signor
|
10426999
|
FOXO3
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
808.0
|
0.8
|
STRING
|
36370105
|
CDK2
|
CDC25A
|
â—¼ PHOSPHORYLATION
|
✅
|
-
|
0.81
|
0.81
|
Signor
|
17110335
|
CDC25A
|
CDK2
|
â—¼ DEPHOSPHORYLATION
|
✅
|
+
|
0.81
|
0.81
|
Signor
|
22263797
|
MDM2
|
CDKN2A
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.81
|
0.81
|
mint
|
7989562
20713054
|
MDM2
|
XRCC6
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.81
|
0.81
|
HIPPIE
|
24583282
18784078
24147044
19247369
|
MTOR
|
STAT3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.81
|
0.81
|
HIPPIE
|
10660304
24931163
23329839
15522880
|
CCNA1
|
SKP2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.81
|
0.81
|
HIPPIE
|
16774918
19270695
17308064
10652300
|
RAD18
|
TP53BP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
817.0
|
0.81
|
STRING
|
36370105
|
APBB1
|
HERC2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
PPARG
|
ASH2L
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
19047629
24368734
|
BRCA1
|
ASH2L
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
22990118
26831064
|
ATRX
|
XRCC6
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
30585729
23329831
|
BRCA1
|
TINF2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
34112789
29656893
|
MDC1
|
BRCC3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
22990118
29656893
|
CDK2
|
E2F4
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
33961781
25852190
|
HERC2
|
EME1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
25476789
29426014
|
ACTB
|
EP300
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
33742100
21988832
|
HDAC6
|
EP300
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
19344692
15102857
12718889
22778253
23133622
|
HERC2
|
LMNA
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
25476789
29426014
|
SKP2
|
MCM8
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
MCM8
|
MLH1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
33961781
26300262
|
MSH2
|
MCM8
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
33961781
26300262
|
MCM9
|
RFC2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
26300262
26870752
|
MCM9
|
RFC4
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
26300262
26870752
|
MDC1
|
MDM2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
14578343
18471438
|
XRCC6
|
MSH2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
22863883
21075794
|
LRRK2
|
MSH2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
31046837
24725412
|
MYC
|
RFC1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
17353931
29467282
|
MYC
|
ILF2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
30415952
29467282
|
MYC
|
RAD50
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
21150319
29467282
|
MYC
|
XRCC5
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
17314511
29467282
|
MYC
|
PRKDC
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
17314511
29467282
|
MYC
|
DDX1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
17314511
29467282
|
MRE11
|
NBN
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.82
|
0.82
|
mint
|
24981860
|
ETS1
|
PIAS4
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
17456046
16862185
|
PRKDC
|
MRE11
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
20808282
10608806
|
RFC4
|
RAD1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
XRCC5
|
RFC1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
12393188
26344197
|
RFC1
|
XRCC6
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
30585729
26344197
|
XRCC6
|
BARD1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
15782130
22990118
|
BARD1
|
AURKB
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
19176389
22350409
|
DDX1
|
MRE11
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
22863883
18710941
|
ILF2
|
MRE11
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
20808282
22863883
|
MCM5
|
ILF2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
20808282
25963833
|
LIN54
|
E2F4
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
17671431
17531812
|
SKP2
|
OFD1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
AKT2
|
UBE2O
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
NSD2
|
LMNA
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
34079125
22751105
|
MCM5
|
LMNA
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
24623722
25963833
|
MCM5
|
ILF3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
20808282
25963833
|
ATM
|
CHEK1
|
â—¼ PHOSPHORYLATION
|
✅
|
+
|
0.82
|
0.82
|
Signor
|
20068082
|
ATM
|
MDC1
|
â—¼ PHOSPHORYLATION
|
✅
|
+
|
0.82
|
0.82
|
Signor
|
12607003
|
KRAS
|
MAPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
824.0
|
0.82
|
STRING
|
36370105
|
NBN
|
TERF2IP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
824.0
|
0.82
|
STRING
|
36370105
|
ATRX
|
HIST3H3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
826.0
|
0.82
|
STRING
|
36370105
|
ATRX
|
NBN
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
24651726
27171262
23329831
|
ATRX
|
RAD50
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
24651726
23329831
|
BRCA1
|
TERF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
34112789
19797051
29656893
|
BRCA1
|
TERF2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
34112789
25184681
19797051
29656893
|
BRCA1
|
RAD18
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
29656893
25184681
23901102
|
CCND1
|
RFC1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
10353443
21654808
|
CCNA2
|
EP300
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
26186194
|
SIRT1
|
EP300
|
â—¼ DEACETYLATION
|
✅
|
-
|
0.83
|
0.83
|
Signor
|
19047049
|
PPP5C
|
HSP90AA1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.83
|
0.83
|
mint
|
27880917
|
KAT5
|
STAT3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
12551922
16713569
|
BARD1
|
MDC1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
12611903
29656893
|
ACTB
|
MDM2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
24583282
24798327
17373842
|
MYC
|
NONO
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
21150319
17314511
17967896
29467282
|
MYC
|
LMNA
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
21150319
17314511
29467282
|
RNF8
|
NONO
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
30445466
34017080
|
LRRK2
|
PRKDC
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
19826009
31046837
17400507
|
LIN54
|
LIN52
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
17671431
33961781
17531812
|
LIN9
|
E2F4
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
17671431
17563750
17531812
17159899
33961781
|
CCND2
|
RBL2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
26186194
|
CCNA2
|
CCNA1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
26186194
|
BRCA1
|
RBBP8
|
â—¼ UBIQUITINATION
|
✅
|
+
|
0.83
|
0.83
|
Signor
|
16818604
|
RBBP8
|
BRCA1
|
â—¼ RELOCALIZATION
|
✅
|
+
|
0.83
|
0.83
|
Signor
|
24832651
|
CHEK2
|
TP53BP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
832.0
|
0.83
|
STRING
|
36370105
|
ATM
|
NBN
|
â—¼ PHOSPHORYLATION
|
✅
|
+
|
0.83
|
0.83
|
Signor
|
10802669
|
CCND1
|
EP300
|
â—¼ PHYSICAL_INTERACTION
|
|
|
835.0
|
0.83
|
STRING
|
36370105
|
KAT5
|
MDM2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
835.0
|
0.83
|
STRING
|
36370105
|
MDM2
|
NPM1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
835.0
|
0.83
|
STRING
|
36370105
|
MDM2
|
NCL
|
â—¼ PHYSICAL_INTERACTION
|
|
|
835.0
|
0.83
|
STRING
|
36370105
|
MTOR
|
STAT3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
836.0
|
0.83
|
STRING
|
36370105
|
BRCA1
|
UBE2N
|
â—¼ PHYSICAL_INTERACTION
|
|
|
837.0
|
0.83
|
STRING
|
36370105
|
KAT5
|
MYC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
837.0
|
0.83
|
STRING
|
36370105
|
ATR
|
CHEK2
|
â—¼ PHOSPHORYLATION
|
✅
|
+
|
0.83
|
0.83
|
Signor
|
10973490
|
BRCA1
|
CDK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
838.0
|
0.83
|
STRING
|
36370105
|
KAT5
|
APBB1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
32296183
16223726
15044485
16713569
11441186
17368826
15331662
33849647
25342469
14699153
|
ATRX
|
MRE11
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
24651726
27171262
23329831
|
BLM
|
RAD50
|
â—¼ PHYSICAL_INTERACTION
|
|
|
839.0
|
0.84
|
STRING
|
36370105
|
MSH2
|
BLM
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
10783165
15064730
|
MSH6
|
BLM
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
10783165
15064730
|
PRKDC
|
BRCA1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
10608806
25223785
|
E2F1
|
E2F3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
35140242
24981860
20106982
|
FOXO3
|
EP300
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
19592618
25609649
11896584
|
EP300
|
ILF3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
20808282
33742100
|
EP300
|
XRCC6
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
15023334
33742100
21988832
|
LMNA
|
MDC1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
30179224
22412018
30419336
|
NBN
|
MLH1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
17121922
10783165
|
MYC
|
ACTB
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
11839798
29467282
|
CCNB1
|
CCNB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
19879842
26344197
|
FOXO3
|
MDM2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
840.0
|
0.84
|
STRING
|
36370105
|
CCNA1
|
SKP2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
841.0
|
0.84
|
STRING
|
36370105
|
BARD1
|
BRCA2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
842.0
|
0.84
|
STRING
|
36370105
|
CDKN1A
|
EP300
|
â—¼ PHYSICAL_INTERACTION
|
|
|
846.0
|
0.84
|
STRING
|
36370105
|
KRAS
|
NRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
847.0
|
0.84
|
STRING
|
36370105
|
BARD1
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
848.0
|
0.84
|
STRING
|
36370105
|
DAXX
|
ATRX
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.85
|
0.85
|
mint
|
24981860
|
RAD50
|
BLM
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
29523790
25084169
10783165
|
BLM
|
MYC
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
23750012
30415952
29467282
|
CCND1
|
STAT3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
11279133
15659654
|
CDK2
|
RBL2
|
â—¼ PHOSPHORYLATION
|
|
|
0.85
|
0.85
|
Signor
|
11157749
|
ILF2
|
EP300
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
20808282
30110629
33742100
|
EP300
|
PRKDC
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
20808282
30110629
33742100
|
EP300
|
MCM5
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
20808282
30110629
33742100
|
EP300
|
RAD50
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
20808282
16051665
|
MCM9
|
MCM8
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
28514442
26300262
26215093
33961781
26186194
26870752
23401855
|
RNF8
|
NBN
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
18001825
23115235
26869104
|
XRCC4
|
PRKDC
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
15520013
9259561
15194694
22939629
9430729
|
CCND1
|
CDKN2A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
850.0
|
0.85
|
STRING
|
36370105
|
MAPK8
|
NFATC3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
852.0
|
0.85
|
STRING
|
36370105
|
CCND2
|
RBL2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
853.0
|
0.85
|
STRING
|
36370105
|
MDC1
|
TOPBP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
855.0
|
0.85
|
STRING
|
36370105
|
MAPK8
|
NFATC3
|
â—¼ PHOSPHORYLATION
|
✅
|
-
|
0.85
|
0.85
|
Signor
|
14517246
|
ASH2L
|
PAXIP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
856.0
|
0.85
|
STRING
|
36370105
|
E2F1
|
EP300
|
â—¼ PHYSICAL_INTERACTION
|
|
|
857.0
|
0.85
|
STRING
|
36370105
|
ATM
|
PRKDC
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
10608806
10464290
|
NBN
|
BLM
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
29523790
10783165
|
BRCA1
|
RFC1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
16713569
25184681
10783165
|
BRCA1
|
CCNA1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
16713569
9244350
10373534
|
CDK2
|
TP53
|
â—¼ PHOSPHORYLATION
|
✅
|
+
|
0.86
|
0.86
|
Signor
|
24173284
|
EP300
|
STAT3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
10205054
15653507
16713569
33531691
26504087
18782771
30110629
11923478
15735682
15649887
33742100
22116549
|
RAD1
|
FEN1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
30184152
16216273
19535328
15556996
|
PIK3R1
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.86
|
0.86
|
mint
|
5220480
7642581
|
MCM9
|
MSH6
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
26300262
26870752
|
MDM4
|
PELI1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
28514442
29523541
33961781
|
ACD
|
TERF2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
15231715
16880378
15383534
|
BRCA1
|
MSH2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
862.0
|
0.86
|
STRING
|
36370105
|
BLM
|
MSH6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
864.0
|
0.86
|
STRING
|
36370105
|
AURKB
|
HIST3H3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
865.0
|
0.86
|
STRING
|
36370105
|
DYNLL1
|
PPP3R2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.86
|
0.86
|
HuRI
|
32296183
|
CALM2
|
PPP3CA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
867.0
|
0.86
|
STRING
|
36370105
|
ATR
|
TP53BP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
868.0
|
0.86
|
STRING
|
36370105
|
CCNA2
|
BRCA1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
25091198
16713569
9244350
10373534
|
BRCC3
|
BARD1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
14636569
17664283
17525341
|
CCND2
|
CDK2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
9840943
28514442
33854235
33961781
26186194
23455922
9178893
|
MYC
|
EP300
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
15616592
16287840
32140074
16126174
17157259
12776737
|
RNF8
|
HERC2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
26503038
20023648
25305019
22814251
22508508
|
BARD1
|
MSH6
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
16391231
11498787
|
MYC
|
CDK6
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
22094256
28628118
28205554
|
MYC
|
RFC2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
17314511
30415952
29467282
|
LMNA
|
NONO
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
22412018
22939629
25948554
|
XRCC6
|
XRCC1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
28514442
33961781
30585729
|
XRCC6
|
ILF3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
31536960
30585729
21969602
|
RBL2
|
LIN52
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
25917549
17531812
|
LIN9
|
LIN52
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
17671431
28514442
17531812
33961781
24981860
|
LIN9
|
LIN54
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
17671431
33961781
17531812
28514442
|
RBL2
|
LIN54
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
17671431
17531812
19725879
|
RBL2
|
LIN9
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
17671431
17159899
33961781
17531812
|
CDK6
|
CDKN1A
|
â—¼ PHOSPHORYLATION
|
✅
|
-
|
0.87
|
0.87
|
Signor
|
16508017
|
CHEK2
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
870.0
|
0.87
|
STRING
|
36370105
|
FEN1
|
RAD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
870.0
|
0.87
|
STRING
|
36370105
|
E2F4
|
LIN9
|
â—¼ PHYSICAL_INTERACTION
|
|
|
870.0
|
0.87
|
STRING
|
36370105
|
TERF2IP
|
TINF2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
870.0
|
0.87
|
STRING
|
36370105
|
POT1
|
TERF2IP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
870.0
|
0.87
|
STRING
|
36370105
|
APBB1
|
KAT5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
871.0
|
0.87
|
STRING
|
36370105
|
FEN1
|
MSH2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
871.0
|
0.87
|
STRING
|
36370105
|
KAT5
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
871.0
|
0.87
|
STRING
|
36370105
|
MYC
|
SKP2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
871.0
|
0.87
|
STRING
|
36370105
|
RAD50
|
TERF2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
871.0
|
0.87
|
STRING
|
36370105
|
ATR
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
872.0
|
0.87
|
STRING
|
36370105
|
BLM
|
CHEK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
872.0
|
0.87
|
STRING
|
36370105
|
CDKN1A
|
MDM2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
872.0
|
0.87
|
STRING
|
36370105
|
EP300
|
STAT3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
872.0
|
0.87
|
STRING
|
36370105
|
BLM
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
873.0
|
0.87
|
STRING
|
36370105
|
BRCA1
|
MYC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
873.0
|
0.87
|
STRING
|
36370105
|
CDKN1A
|
STAT3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
873.0
|
0.87
|
STRING
|
36370105
|
PRKDC
|
XRCC4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
873.0
|
0.87
|
STRING
|
36370105
|
POT1
|
TERF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
873.0
|
0.87
|
STRING
|
36370105
|
BRCA1
|
MDC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
874.0
|
0.87
|
STRING
|
36370105
|
BRCA1
|
TOPBP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
874.0
|
0.87
|
STRING
|
36370105
|
EP300
|
MDM2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
874.0
|
0.87
|
STRING
|
36370105
|
MAPK1
|
MAPK14
|
â—¼ PHYSICAL_INTERACTION
|
|
|
874.0
|
0.87
|
STRING
|
36370105
|
RAD50
|
TERF2IP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
874.0
|
0.87
|
STRING
|
36370105
|
HSPA4
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
874.0
|
0.87
|
STRING
|
36370105
|
LIG4
|
XRCC6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
874.0
|
0.87
|
STRING
|
36370105
|
PIK3R2
|
PIK3R3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
874.0
|
0.87
|
STRING
|
36370105
|
ACD
|
TERF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
874.0
|
0.87
|
STRING
|
36370105
|
ACD
|
TERF2IP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
874.0
|
0.87
|
STRING
|
36370105
|
ATM
|
BRCA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
875.0
|
0.87
|
STRING
|
36370105
|
BRCA1
|
TP53BP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
875.0
|
0.87
|
STRING
|
36370105
|
BRCA1
|
NBN
|
â—¼ PHYSICAL_INTERACTION
|
|
|
875.0
|
0.87
|
STRING
|
36370105
|
BRIP1
|
TOPBP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
875.0
|
0.87
|
STRING
|
36370105
|
CHEK1
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
875.0
|
0.87
|
STRING
|
36370105
|
ATR
|
BRCA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
876.0
|
0.87
|
STRING
|
36370105
|
BLM
|
FEN1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
876.0
|
0.87
|
STRING
|
36370105
|
BRCA1
|
MLH1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
876.0
|
0.87
|
STRING
|
36370105
|
MAPK1
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
876.0
|
0.87
|
STRING
|
36370105
|
NPM1
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
876.0
|
0.87
|
STRING
|
36370105
|
PIK3R1
|
PIK3R2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
876.0
|
0.87
|
STRING
|
36370105
|
RNF168
|
TP53BP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
876.0
|
0.87
|
STRING
|
36370105
|
DCLRE1C
|
PRKDC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
877.0
|
0.87
|
STRING
|
36370105
|
HRAS
|
NRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
877.0
|
0.87
|
STRING
|
36370105
|
E2F1
|
TOPBP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
878.0
|
0.87
|
STRING
|
36370105
|
E2F1
|
SKP2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
878.0
|
0.87
|
STRING
|
36370105
|
EP300
|
PPARG
|
â—¼ PHYSICAL_INTERACTION
|
|
|
878.0
|
0.87
|
STRING
|
36370105
|
TERF2
|
XRCC6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
878.0
|
0.87
|
STRING
|
36370105
|
ATM
|
MRE11
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
10608806
10783165
15758953
|
MRE11
|
BLM
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
29523790
28506294
10783165
|
BRCA1
|
BLM
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
25084169
10783165
26831064
29656893
|
BRCA1
|
CHEK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
879.0
|
0.88
|
STRING
|
36370105
|
BRCA1
|
UBE2N
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
19712108
21965653
17873885
|
BRCA1
|
RBL2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
21102443
11521194
|
BRCA2
|
BRCC3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
14636569
17664283
|
BRIP1
|
MLH1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
879.0
|
0.88
|
STRING
|
36370105
|
EP300
|
CCND1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
15951563
10567390
11788592
|
FEN1
|
CDK2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
16189514
12853968
|
TRRAP
|
E2F1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
9708738
18542057
11418595
|
CCNA1
|
E2F1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
16774918
10022926
|
NBN
|
EP300
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
21108945
16051665
|
SKP2
|
EP300
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
22770219
18243116
26593157
|
MAPK14
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
879.0
|
0.88
|
STRING
|
36370105
|
MCM9
|
MSH2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
33961781
26300262
26870752
|
MCM9
|
MLH1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
33961781
26300262
26870752
|
PRKDC
|
ILF3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
20808282
9442054
21969602
|
HNF4A
|
RAD50
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
17353931
35140242
|
ACD
|
TERF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
28514442
15383534
15231715
16880378
26496610
33961781
26186194
|
ATM
|
BLM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
880.0
|
0.88
|
STRING
|
36370105
|
CDKN2A
|
MYC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
880.0
|
0.88
|
STRING
|
36370105
|
ATR
|
ATRIP
|
â—¼ PHOSPHORYLATION
|
✅
|
+
|
0.88
|
0.88
|
Signor
|
15451423
|
DAXX
|
MDM2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
881.0
|
0.88
|
STRING
|
36370105
|
CHEK2
|
MUS81
|
â—¼ PHYSICAL_INTERACTION
|
|
|
882.0
|
0.88
|
STRING
|
36370105
|
NBN
|
RBBP8
|
â—¼ PHYSICAL_INTERACTION
|
|
|
882.0
|
0.88
|
STRING
|
36370105
|
MDM4
|
USP7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
883.0
|
0.88
|
STRING
|
36370105
|
PRKDC
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
883.0
|
0.88
|
STRING
|
36370105
|
XRCC5
|
ZRANB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.88
|
0.88
|
HuRI
|
32296183
|
NCL
|
NPM1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
884.0
|
0.88
|
STRING
|
36370105
|
MAPK8
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
884.0
|
0.88
|
STRING
|
36370105
|
PPP1CB
|
PPP1CC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
884.0
|
0.88
|
STRING
|
36370105
|
HDAC6
|
HSP90AA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
885.0
|
0.88
|
STRING
|
36370105
|
SIRT1
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
885.0
|
0.88
|
STRING
|
36370105
|
MAPK1
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
887.0
|
0.88
|
STRING
|
36370105
|
MYC
|
TRRAP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
888.0
|
0.88
|
STRING
|
36370105
|
MDC1
|
ATM
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
29656893
14519663
28943310
12607005
26734725
18006705
|
ATR
|
NBN
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
17526493
10608806
15758953
23368512
|
BRCA1
|
ATRIP
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
17616665
24073851
29656893
|
BLM
|
FEN1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
14688284
16326861
|
NBN
|
BRCA1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
10426999
18171670
19244116
12124328
10783165
25659039
25184681
25939603
11504724
29656893
|
MDC1
|
BRCA1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
21622030
19766185
15569676
12611903
17525332
12607005
29656893
|
CCNB1
|
BRCA1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
16713569
11278247
23246971
9244350
|
CCND1
|
BRCA1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
17334399
16713569
9244350
|
E2F4
|
BRCA1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
21102443
16713569
9244350
|
MLH1
|
BRIP1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.89
|
0.89
|
mint
|
5220047
17581638
|
E2F1
|
CDK2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
8458319
7969176
9199321
1530885
11245432
|
KAT5
|
MYC
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
12776177
15572685
18003922
35140242
30415952
20946988
|
MAPK1
|
STAT3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
889.0
|
0.89
|
STRING
|
36370105
|
MAPK14
|
MKNK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
889.0
|
0.89
|
STRING
|
36370105
|
NSD2
|
MDC1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
21293379
31248990
|
MDM2
|
DAXX
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.89
|
0.89
|
mint
|
6799761
18566590
|
MYC
|
MLH1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
12584560
29467282
|
XRCC6
|
MSH6
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
22863883
30585729
21075794
|
MYC
|
MSH6
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
17353931
17314511
29467282
|
RFC4
|
MYC
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
21150319
17353931
30415952
29467282
|
MYC
|
XRCC6
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
17314511
30415952
29467282
|
MYC
|
SKP2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
23277542
12769844
12963825
26038816
17157259
24259667
|
TERF2
|
NBN
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
22939629
19287395
10888888
|
ILF2
|
PRKDC
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
20808282
17389650
9442054
|
RAD50
|
RINT1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
16600870
11096100
|
UBE2N
|
RNF8
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
31048496
25909880
29523790
19549727
22589545
21706008
24732096
18678647
28244869
20023648
21911360
16215985
26285145
23255131
27909234
22814251
31792955
|
XRCC4
|
XRCC6
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
17124166
15520013
26774286
26496610
|
MRE11
|
XRCC6
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
30585729
10508516
26344197
|
XRCC6
|
TERF2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
21044950
26496610
10984620
|
TERF2
|
MRE11
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
22939629
19287395
10888888
18212065
|
CDK6
|
CDKN2B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
889.0
|
0.89
|
STRING
|
36370105
|
DAXX
|
ETS1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
15247905
16861237
10698492
|
RBL2
|
CCNA2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
28514442
12006580
17531812
33961781
26186194
8253383
|
ATM
|
CHEK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
891.0
|
0.89
|
STRING
|
36370105
|
CDKN1A
|
SKP2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
892.0
|
0.89
|
STRING
|
36370105
|
CDKN2A
|
NPM1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
892.0
|
0.89
|
STRING
|
36370105
|
CCNA2
|
E2F1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
892.0
|
0.89
|
STRING
|
36370105
|
CCNA2
|
RBL2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
892.0
|
0.89
|
STRING
|
36370105
|
HRAS
|
KRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
893.0
|
0.89
|
STRING
|
36370105
|
DAXX
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
895.0
|
0.89
|
STRING
|
36370105
|
CDC25A
|
CHEK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
896.0
|
0.89
|
STRING
|
36370105
|
MDC1
|
RAD50
|
â—¼ PHYSICAL_INTERACTION
|
|
|
896.0
|
0.89
|
STRING
|
36370105
|
POT1
|
TINF2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
897.0
|
0.89
|
STRING
|
36370105
|
CDK2
|
RBL2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
898.0
|
0.89
|
STRING
|
36370105
|
CCNB1
|
CDKN1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
898.0
|
0.89
|
STRING
|
36370105
|
CDKN2A
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
898.0
|
0.89
|
STRING
|
36370105
|
TERF1
|
ATM
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
18160036
11375976
15314656
|
ATM
|
BRCA1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
11114888
11278964
29656893
10783165
11016625
10866324
10550055
15713674
18344987
10608806
17478428
|
ATM
|
NBN
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
24800743
10783165
25088203
11252893
30952868
10608806
17507690
22464731
25895060
10839545
15758953
10839544
|
ATM
|
BLM
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
29523790
10783165
12034743
|
TP53
|
ATM
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
9843217
9733515
9733514
|
E2F1
|
ATM
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
22832221
23993922
12527885
|
FOXO3
|
ATM
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
18344987
|
KAT5
|
ATM
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
16141325
|
ATRIP
|
ATR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
19097996
28514442
19889979
17384638
15758953
14724280
15451423
23144622
26854234
21285353
18344416
20847938
20616048
15743907
14657349
11721054
15538388
17686975
18162465
17526493
33961781
15210935
18283122
|
ATR
|
BRCA1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
11114888
11278964
23901102
29656893
16713569
11016625
10608806
17478428
|
CHEK1
|
ATR
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
15190204
10859164
11390642
|
TOPBP1
|
ATRIP
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
20068082
18769153
|
DAXX
|
ATRX
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
22102817
31628488
27872097
24651726
29937341
26496610
15252119
28875283
28875424
34162889
14990586
20147399
29084956
12953102
23329831
25416818
31631027
33961781
23135716
24981860
27029610
23222847
|
BRCA1
|
BACH1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
17664283
15208681
16713569
19369211
17525340
15125843
15242590
16391231
25252691
11301010
11877378
|
BLM
|
MLH1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
12724401
10783165
11691925
11325959
21466675
11470874
19015241
|
BLM
|
TERF2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
12181313
19329795
15229185
|
BRIP1
|
BLM
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
21240188
|
PALB2
|
BRCA1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
19369211
25184681
19584259
23038782
29656893
26649820
30337689
28319063
28089683
28398198
22193777
19268590
22331464
34408138
23585894
25016020
19553677
24085845
25652403
|
EP300
|
BRCA1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
21102443
19887647
10655477
11782371
16713569
21212407
22787115
|
MYC
|
BRCA1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
12646176
11916966
16713569
20215511
9788437
30415952
14612409
|
MLH1
|
BRCA1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
10783165
17148452
25184681
16786532
21240188
29656893
|
BRCA2
|
BRCA1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
11477095
17664283
16713569
21135251
19369211
9774970
25184681
14636569
24085845
34408138
25652403
14499622
29656893
|
CDK2
|
BRCA1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
31270457
16713569
10373534
9244350
8764100
|
BRCA1
|
MSH6
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
16260778
25184681
11498787
10783165
|
BRCA1
|
MRE11
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
10426999
10783165
17349954
25184681
23530059
16391231
11353843
24413181
11504724
29656893
|
BRCA1
|
MSH2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
11498787
16713569
10783165
15886699
16260778
|
BRCA1
|
BRCC3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
19305427
17664283
19202061
22990118
25184681
14636569
25252691
29656893
|
BRCA1
|
RAD50
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
10426999
18171670
12124328
16713569
10783165
25084169
25184681
16260778
16391231
11504724
29656893
|
E2F5
|
BRCA1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
17106239
|
E2F2
|
BRCA1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
17106239
|
E2F3
|
BRCA1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
17106239
|
PALB2
|
BRCA2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
20332121
19369211
24485656
17200672
24141787
19584259
28240985
23038782
16793542
26833090
26649820
28319063
24835992
30410870
17420451
28398198
22193777
19268590
21466675
22331464
19609323
26990772
23585894
25016020
19553677
28765325
33961781
20871615
22293751
|
BRCA2
|
BARD1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
14636569
17664283
16391231
19176389
|
MYC
|
BRCA2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12695333
|
CHEK1
|
BRCA2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
18317453
24627786
|
CCND1
|
CDK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
899.0
|
0.9
|
STRING
|
36370105
|
CCND1
|
E2F4
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
11884610
7797074
9144196
|
ETS1
|
CCND1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
19499154
15579511
|
FOXM1
|
CCND1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
23812424
19097132
11572993
|
E2F4
|
CCND1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
10594784
7929342
9584162
|
FOXO3
|
CCND1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
12391153
21294163
|
E2F4
|
CDC25A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
11799067
9858615
|
TP53
|
CDC25A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
18281511
17001315
19060337
|
MAPKAPK2
|
CDC25A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
15629715
17292828
|
SKP2
|
CDK2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
28514442
16189514
9858587
9636170
25852190
23455922
10559858
19270695
26496610
23602568
16979657
10386600
19686743
15355997
20160477
18604603
22770219
33422522
33961781
26186194
7553852
|
RBL2
|
CDK2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
28514442
9891079
17531812
25852190
9472014
33961781
26186194
23602568
10825149
23455922
9188854
|
CDK2
|
EP300
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
28514442
33961781
26186194
10330164
23455922
|
CDK2
|
BARD1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
15855157
15665273
31270457
|
HSP90AA1
|
CDKN1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
15664193
9844631
20018861
|
MSH2
|
CDKN1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
intact
|
21900206
2001699
8089645
|
ACTB
|
CDKN1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
intact
|
21900206
2001699
8089645
|
CDKN1A
|
TLE1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
intact
|
21900206
2001699
8089645
|
CDKN1A
|
USP4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
intact
|
21900206
2001699
8089645
|
CDKN1A
|
E2F4
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
11884610
7797074
9144196
|
KAT5
|
CDKN1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
17671089
20351180
16601686
|
ETS1
|
CDKN1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
18955504
12740370
|
SIRT1
|
CDKN1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
23474493
15130752
21719763
|
GATA3
|
CDKN2A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
19340300
|
CHEK1
|
E2F3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
19917728
|
CHEK2
|
TERF2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
26799419
19375317
|
SKP2
|
E2F1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
12097298
17471231
23868976
27720894
16170383
10559858
|
E2F1
|
CCNA2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
8458319
7969176
12501191
35140242
9724724
|
E2F4
|
E2F1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
14576826
10208422
|
E2F1
|
XRCC1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
19031698
18348985
|
E2F1
|
MDM2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
10914734
20837136
|
E2F1
|
FOXM1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
21518729
22802261
|
E2F3
|
E2F1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
14576826
10766737
18319725
|
E2F4
|
E2F1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
14576826
10766737
18319725
|
EP300
|
E2F1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
10753885
15123636
15126619
|
E2F1
|
PPARG
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
15711575
12110166
18319725
|
E2F1
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
11564866
18319725
90001421
|
EME1
|
MUS81
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
19596236
28514442
16189514
25224045
27354282
24733841
25319828
21962513
29738624
19017809
33961781
28575661
14617801
12686547
12721304
17289582
19363487
18413719
|
EP300
|
MDM2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
15154850
20234175
16713569
11070080
9809062
28196907
15013777
|
EP300
|
PPARG
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
11500849
17468099
10944516
14701856
11287611
19596656
32603375
11877444
12040021
10075656
30595551
22787115
12479814
|
EP300
|
FEN1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
11430825
20019387
16326861
|
MDM2
|
EP300
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
9809062
11070080
16713569
|
EP300
|
HDAC6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
15102857
19344692
|
MAPK6
|
FOXO3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
intact
|
21900206
2001699
8089645
|
FOXO3
|
RBL2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
11884591
16493026
|
MAPK3
|
FOXO3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
19282669
|
PIK3CD
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
11002419
10995764
10448070
|
HLA-C
|
GRB2
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
3.0
|
0.9
|
ACSN
|
11513144
21339333
9605119
|
HRAS
|
HSP90AA1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
16024644
15118125
15284455
|
NRAS
|
HSP90AA1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
16024644
15118125
15284455
|
KRAS
|
HSP90AA1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
16024644
15118125
15284455
|
STAT3
|
HSP90AA1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
9880553
10440232
23228483
|
MYC
|
HSP90AA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
28914785
12644583
|
KAT5
|
MDM2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
18499675
11927554
18264029
19150978
|
MDM2
|
KAT5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
11927554
16904321
|
MAPK1
|
MAP2K2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
10567369
19219045
8013650
|
TP53
|
MAPK14
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
11437382
15132979
14570892
|
MAPK3
|
MAP2K2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
10567369
19219045
8013650
|
MAP2K3
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
8226933
|
E2F4
|
MCM8
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
17531812
16325355
|
RNF8
|
MDC1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
25512560
28943310
24240613
18001825
26734725
18001824
18006705
|
MDC1
|
RAD50
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
30179224
29656893
14519663
12607005
12607003
18583988
|
MDC1
|
NBN
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
15377652
30179224
12607003
18678890
29656893
27590578
25064736
20460517
19804756
23115235
14519663
15201865
12607005
20224574
18001824
18583988
|
MDC1
|
MRE11
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
30179224
29656893
20081839
14519663
12607005
12607003
18583988
|
MDM4
|
MDM2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
28514442
10629057
32300648
25512388
21988832
25384516
25809483
17616658
25105592
12874296
31796886
29295817
32075226
20705607
17301054
22493164
25703327
27777309
29523541
27617579
23028042
20473904
22120712
22333590
22902369
22745160
12860999
19432880
21925390
28205554
25659040
19838211
33985974
16055726
25961923
32427989
18566590
22266850
18219319
29057323
10608892
30598450
29524278
25825738
17159902
24813712
31024344
27621617
15604276
29262653
19619542
10218570
28628118
16227609
10827196
12393902
24755078
20724842
34551723
27215386
11606419
20484049
12370303
23671280
26001071
26720344
33961781
12483531
23946421
19683495
26359458
|
PRKDC
|
MDM2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
17570479
22444248
10721693
|
TP53
|
MLH1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
18431400
15781865
|
MYC
|
MSH2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
28628118
17314511
12584560
29467282
28205554
30415952
|
TP53
|
MSH2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
11350971
8630028
|
TRRAP
|
MYC
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
11839798
19818711
9708738
17314511
17353931
10611234
16705173
11511539
32140074
21150319
35140242
12660246
29467282
30415952
12077335
20946988
|
MYC
|
NRAS
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12695333
|
MYC
|
PRKDC
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12695333
|
MYC
|
RFC2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12747840
|
MYC
|
SMARCAD1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12747840
|
MYC
|
LMNA
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12695333
|
MYC
|
SIRT1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12695333
|
E2F4
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
11564866
12150994
18319725
|
NBN
|
MRE11
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
30179224
11238951
17612497
22941933
23530059
15758953
11062235
10426999
19244116
10783165
18458108
21884979
22464731
33558481
24413181
26455393
12447395
12679336
28369484
22078559
34038735
22231403
12419185
22939629
34348893
17526493
12861053
17500065
12750284
9705271
28363998
30440001
24981860
19270065
12607003
15734743
|
XRCC5
|
PRKDC
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
15941674
10750018
20023628
17308091
15758953
20085707
33005030
10446239
26496610
19303849
20711232
9312071
26446488
15520013
28154079
28345663
16857680
12393188
22404984
21679440
26344197
|
XRCC6
|
PRKDC
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
20711232
21575865
33005030
28345663
15941674
10064605
26496610
26446488
15520013
10750018
8422676
26175416
22939629
17308091
30585729
19303849
21969602
|
PRKDC
|
VCP
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
16140914
|
UBE2N
|
RAD18
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
18719106
18316726
19723507
|
UBE2V2
|
RAD18
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
18719106
18316726
19723507
|
TERF2
|
RAD50
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
19287395
15100233
10888888
18212065
22939629
|
RBBP8
|
MRE11
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
17965729
21052091
|
SIRT1
|
PPARG
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
15850715
21633182
|
STAT3
|
TP53
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
16107692
23874455
20043094
|
STAT3
|
CCND2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
24287565
12147685
|
PPARG
|
TP53
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
16887883
14960510
|
TP53
|
CCNA1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
17530187
15456866
|
TP53
|
DDR1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
8977099
21398698
|
TP53
|
ETS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
15469934
14586398
|
XRCC6
|
XRCC5
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
15910003
19177010
28514442
28035050
14681455
10750018
17159921
25574025
17308091
10984620
11196700
32296183
7699019
33005030
15367688
12145306
19118032
10446239
26496610
19906305
26774286
10207052
21454661
18809223
9488450
26446488
15520013
30021884
22939629
17283121
10219089
10757784
21070772
11493912
21172662
15023334
22863883
22451927
21679440
24981860
10783163
33961781
30585729
26344197
|
CDK6
|
CCND2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
16189514
16713569
28628118
10022865
28205554
11360184
30217970
33961781
23602568
11358847
9178893
|
CDK6
|
E2F4
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
11884610
7797074
9144196
|
E2F4
|
RBL2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
17671431
21102443
12006580
9858615
17531812
9121766
9343408
17159899
11573202
23108140
22002537
20133863
16600870
12401786
|
CCND2
|
E2F4
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
11884610
7797074
9144196
|
E2F4
|
PPARG
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
15711575
12110166
18319725
|
E2F4
|
CCNB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
15510213
|
E2F4
|
CCNA2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
15510213
10766737
18319725
|
TINF2
|
ACD
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
28514442
32296183
16189514
21044950
25416956
16713569
15383534
15181449
15231715
25910212
16880378
26496610
33961781
|
TINF2
|
TERF2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
23307557
15316005
28514442
21044950
15383534
15181449
15231715
19287395
16880378
15292264
20811636
26496610
33961781
|
SKP2
|
CCNA2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
28514442
9858587
26496610
27720894
33422522
16209941
33961781
24632684
15355997
26186194
7553852
31181401
20160477
10559858
33989513
18604603
|
CCNA2
|
SKP2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
9858587
15355997
33989513
|
SKP2
|
CCNA2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
9858587
15355997
33989513
|
MAPK6
|
DDR1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
intact
|
21900206
2001699
8089645
|
E2F5
|
RBL2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
7760804
11756542
16600870
17531812
|
E2F2
|
MCM5
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
10327050
24038359
|
KDM4B
|
H3C2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
30759871
18022353
|
BRCA1
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
900.0
|
0.9
|
STRING
|
36370105
|
CDK6
|
CDKN1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
900.0
|
0.9
|
STRING
|
36370105
|
HSP90AA1
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
900.0
|
0.9
|
STRING
|
36370105
|
HSP90AA1
|
HSPA4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
901.0
|
0.9
|
STRING
|
36370105
|
RNF8
|
UBE2N
|
â—¼ PHYSICAL_INTERACTION
|
|
|
901.0
|
0.9
|
STRING
|
36370105
|
CCNA2
|
SKP2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
901.0
|
0.9
|
STRING
|
36370105
|
CCND2
|
CDK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
903.0
|
0.9
|
STRING
|
36370105
|
SIRT1
|
FOXO3
|
â—¼ DEACETYLATION
|
✅
|
-
|
0.9
|
0.9
|
Signor
|
24003218
|
GRB2
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
908.0
|
0.9
|
STRING
|
36370105
|
PALB2
|
BRCA1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.91
|
0.91
|
mint
|
8329239
22193777
|
PALB2
|
BRCA1
|
â—¼ COLOCALIZATION
|
✅
|
|
0.91
|
0.91
|
mint
|
28319063
|
BRCA1
|
PALB2
|
â—¼ COLOCALIZATION
|
✅
|
|
0.91
|
0.91
|
mint
|
8329239
22193777
|
MAPK1
|
MAPKAPK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
909.0
|
0.91
|
STRING
|
36370105
|
ATM
|
TP53BP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
910.0
|
0.91
|
STRING
|
36370105
|
CCND2
|
CDKN1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
910.0
|
0.91
|
STRING
|
36370105
|
CDK2
|
SKP2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
911.0
|
0.91
|
STRING
|
36370105
|
CDKN2A
|
MDM2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
913.0
|
0.91
|
STRING
|
36370105
|
ATM
|
NBN
|
â—¼ PHYSICAL_INTERACTION
|
|
|
914.0
|
0.91
|
STRING
|
36370105
|
ACD
|
TINF2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
914.0
|
0.91
|
STRING
|
36370105
|
ATM
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
915.0
|
0.91
|
STRING
|
36370105
|
TP53
|
USP7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
916.0
|
0.91
|
STRING
|
36370105
|
MDC1
|
NBN
|
â—¼ PHYSICAL_INTERACTION
|
|
|
917.0
|
0.91
|
STRING
|
36370105
|
MLH1
|
MSH6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
917.0
|
0.91
|
STRING
|
36370105
|
E2F5
|
RBL2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
917.0
|
0.91
|
STRING
|
36370105
|
CCNB2
|
CDK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
918.0
|
0.91
|
STRING
|
36370105
|
EP300
|
TP53
|
â—¼ POLYUBIQUITINATION
|
✅
|
-
|
0.91
|
0.91
|
Signor
|
12690203
|
ILF2
|
ILF3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
918.0
|
0.91
|
STRING
|
36370105
|
CCND1
|
CDK6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
919.0
|
0.92
|
STRING
|
36370105
|
TLE1
|
HMGB1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.92
|
0.92
|
HIPPIE
|
11748221
16189514
|
HSP90AA1
|
LRRK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
919.0
|
0.92
|
STRING
|
36370105
|
HDAC6
|
MSH2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.92
|
0.92
|
HIPPIE
|
24882211
23703321
|
ATR
|
CHEK1
|
â—¼ PHOSPHORYLATION
|
✅
|
+
|
0.92
|
0.92
|
Signor
|
15775976
|
MDM2
|
USP7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
920.0
|
0.92
|
STRING
|
36370105
|
CCNA2
|
CDKN1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
921.0
|
0.92
|
STRING
|
36370105
|
FEN1
|
MSH6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
922.0
|
0.92
|
STRING
|
36370105
|
MAP2K6
|
MAPK14
|
â—¼ PHYSICAL_INTERACTION
|
|
|
922.0
|
0.92
|
STRING
|
36370105
|
BTRC
|
CDC25A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
923.0
|
0.92
|
STRING
|
36370105
|
MAP2K2
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
924.0
|
0.92
|
STRING
|
36370105
|
CCNA1
|
CDKN1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
927.0
|
0.92
|
STRING
|
36370105
|
MAP2K3
|
MAPK14
|
â—¼ PHYSICAL_INTERACTION
|
|
|
928.0
|
0.92
|
STRING
|
36370105
|
MDM4
|
MDM2
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.93
|
0.93
|
mint
|
15604276
5217417
|
MDM4
|
MDM2
|
â—¼ COLOCALIZATION
|
✅
|
|
0.93
|
0.93
|
mint
|
17159902
5219425
|
BLM
|
MUS81
|
â—¼ PHYSICAL_INTERACTION
|
|
|
932.0
|
0.93
|
STRING
|
36370105
|
CCNA1
|
CDK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
933.0
|
0.93
|
STRING
|
36370105
|
LIN54
|
LIN9
|
â—¼ PHYSICAL_INTERACTION
|
|
|
933.0
|
0.93
|
STRING
|
36370105
|
NBN
|
RAD50
|
â—¼ PHYSICAL_INTERACTION
|
|
|
934.0
|
0.93
|
STRING
|
36370105
|
HIST3H3
|
KDM4A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
935.0
|
0.93
|
STRING
|
36370105
|
BLM
|
PAXIP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
936.0
|
0.93
|
STRING
|
36370105
|
XRCC6
|
PRKDC
|
â—¼ RELOCALIZATION
|
✅
|
+
|
0.93
|
0.93
|
Signor
|
19133841
|
TERF1
|
TINF2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
937.0
|
0.93
|
STRING
|
36370105
|
MCM8
|
MCM9
|
â—¼ PHYSICAL_INTERACTION
|
|
|
938.0
|
0.93
|
STRING
|
36370105
|
KAT5
|
ACTB
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.94
|
0.94
|
HIPPIE
|
27153538
10966108
20946988
|
MSH6
|
MLH1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.94
|
0.94
|
HIPPIE
|
12799449
30770470
10783165
10748159
|
CCND2
|
CDK6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
939.0
|
0.94
|
STRING
|
36370105
|
BRCA1
|
PALB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
940.0
|
0.94
|
STRING
|
36370105
|
BLM
|
MLH1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
941.0
|
0.94
|
STRING
|
36370105
|
PAXIP1
|
TP53BP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
945.0
|
0.94
|
STRING
|
36370105
|
FOXO3
|
SIRT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
946.0
|
0.94
|
STRING
|
36370105
|
CHEK1
|
CHEK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
947.0
|
0.94
|
STRING
|
36370105
|
ATR
|
BLM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
949.0
|
0.95
|
STRING
|
36370105
|
CDKN1A
|
CCND2
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.95
|
0.95
|
mint
|
16765349
5218735
|
MSH2
|
MLH1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.95
|
0.95
|
HIPPIE
|
25241761
10783165
31843968
30770470
12799449
10748159
|
MDC1
|
TP53BP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
951.0
|
0.95
|
STRING
|
36370105
|
HMGB1
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
952.0
|
0.95
|
STRING
|
36370105
|
MLH1
|
MSH2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
952.0
|
0.95
|
STRING
|
36370105
|
KAT5
|
TRRAP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
953.0
|
0.95
|
STRING
|
36370105
|
BLM
|
TP53BP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
956.0
|
0.95
|
STRING
|
36370105
|
CDK2
|
CDKN1A
|
â—¼ PHOSPHORYLATION
|
✅
|
-
|
0.95
|
0.95
|
Signor
|
15964852
|
ATR
|
MSH2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.96
|
0.96
|
HIPPIE
|
14657349
21285353
33005030
|
CCND1
|
CDK2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.96
|
0.96
|
HIPPIE
|
9840943
28514442
8647086
33854235
8479754
26496610
33854239
33961781
23455922
21654808
9178893
|
CCNB1
|
CDK2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.96
|
0.96
|
HIPPIE
|
20733051
28514442
9891079
7799941
8397207
25852190
26496610
33961781
26186194
23602568
10995390
23455922
30674583
18471975
|
CCNB2
|
CDK2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.96
|
0.96
|
HIPPIE
|
15232106
28514442
24358021
33961781
26186194
23455922
|
KAT5
|
TRRAP
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.96
|
0.96
|
HIPPIE
|
28514442
27153538
16387653
20070254
33961781
10966108
26186194
14966270
20946988
|
TP53
|
MDM4
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.96
|
0.96
|
mint
|
7290688
19521340
|
TP53
|
MDM4
|
â—¼ COLOCALIZATION
|
✅
|
|
0.96
|
0.96
|
mint
|
7290688
19521340
|
XRCC6
|
XRCC5
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.96
|
0.96
|
mint
|
5219440
17159921
|
XRCC5
|
XRCC6
|
â—¼ PHOSPHORYLATION
|
✅
|
|
0.96
|
0.96
|
mint
|
10783163
5212534
|
ILF3
|
ILF2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.96
|
0.96
|
HIPPIE
|
28514442
16189514
20808282
23986595
33961781
17389650
26186194
29395067
22939629
26472337
11739746
21969602
|
MCM5
|
WDHD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
964.0
|
0.96
|
STRING
|
36370105
|
ATM
|
ATR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
965.0
|
0.96
|
STRING
|
36370105
|
HSP90AA1
|
PPP5C
|
â—¼ PHYSICAL_INTERACTION
|
|
|
965.0
|
0.96
|
STRING
|
36370105
|
CDC25A
|
CHEK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
966.0
|
0.96
|
STRING
|
36370105
|
CHEK1
|
TP53BP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
967.0
|
0.96
|
STRING
|
36370105
|
RNF169
|
USP7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
967.0
|
0.96
|
STRING
|
36370105
|
CDKN1A
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
968.0
|
0.96
|
STRING
|
36370105
|
E2F4
|
RBL2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
968.0
|
0.96
|
STRING
|
36370105
|
BARD1
|
BRCA1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
12431996
17525341
29367421
27977889
19916563
12732733
10477523
20060929
23680151
8944023
22110403
12951069
23086937
14638690
27239795
29355525
9788437
11925436
11257228
24289923
14647430
19176389
15184379
9738006
16403807
29180510
11278247
33589814
15265711
15159397
34408138
16713569
19117993
20681793
16391231
11301010
16489000
23416467
17664283
15569676
29858377
19369211
18493658
29656893
20351172
28398198
12485996
32347575
19766185
14636569
10026184
12700228
31270457
11573085
11526114
24085845
25823446
33961781
32092106
18936166
28514442
20215511
25184681
26490435
28948225
12890688
12438698
28262780
26831064
9342365
10635334
15855157
11504724
11773071
25252691
9798686
26350354
21901007
24695549
12887909
17873885
11498787
27454289
11927591
24981860
25652403
25634209
|
PALB2
|
BRCA2
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.97
|
0.97
|
mint
|
19609323
7262167
|
CDK6
|
CCND1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
15232106
16713569
10022865
24855949
17517622
33854235
11739795
14681455
24953629
11360184
33961781
10580009
17420273
21654808
11160398
9178893
19075005
|
NBN
|
MDC1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.97
|
0.97
|
mint
|
20224574
7891431
|
USP7
|
MDM2
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.97
|
0.97
|
mint
|
6799761
18566590
|
DAXX
|
MDM2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
23405218
18566590
18583933
16845383
15364927
20195357
28875283
23038753
21134643
|
RAD50
|
NBN
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
30179224
12607003
12124328
11238951
17612497
22941933
23530059
24651726
15758953
11062235
10426999
10783165
22464731
19197236
12447395
12679336
26215093
22939629
34348893
17526493
17500065
9705271
16391231
30440001
24981860
26344197
15734743
|
RFC1
|
RFC2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
9488738
14681455
15655353
18245774
22939629
26344197
|
USP7
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.97
|
0.97
|
mint
|
5215220
11923872
|
TP53
|
USP7
|
â—¼ DEUBIQUITINATION
|
✅
|
|
0.97
|
0.97
|
mint
|
5215220
11923872
|
TINF2
|
TERF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
28514442
17589526
15316005
21044950
15133513
25416956
19487455
15383534
15181449
16880378
10581025
26496610
20811636
28216227
33961781
26186194
16169070
11701125
|
TERF2IP
|
TERF2
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.97
|
0.97
|
mint
|
8286516
21829167
|
LIN52
|
LIN9
|
â—¼ PHYSICAL_INTERACTION
|
|
|
970.0
|
0.97
|
STRING
|
36370105
|
DCLRE1B
|
TERF2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
973.0
|
0.97
|
STRING
|
36370105
|
NBN
|
TERF2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
973.0
|
0.97
|
STRING
|
36370105
|
LIG3
|
XRCC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
975.0
|
0.97
|
STRING
|
36370105
|
CDK2
|
CCNA2
|
â—¼ PHOSPHORYLATION
|
✅
|
+
|
0.97
|
0.97
|
Signor
|
10652300
|
ATR
|
CHEK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
978.0
|
0.97
|
STRING
|
36370105
|
TERF2
|
TINF2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
978.0
|
0.97
|
STRING
|
36370105
|
BRIP1
|
BRCA1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.98
|
0.98
|
mint
|
5220047
17581638
|
CDKN1A
|
CDK2
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.98
|
0.98
|
mint
|
16765349
5218735
|
TP53
|
EP300
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.98
|
0.98
|
mint
|
16611888
6599495
|
RFC1
|
RFC4
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.98
|
0.98
|
HIPPIE
|
28514442
9488738
22939629
14681455
33961781
18245774
9092549
26344197
|
BRCA1
|
RBBP8
|
â—¼ PHYSICAL_INTERACTION
|
|
|
981.0
|
0.98
|
STRING
|
36370105
|
BRCA1
|
BRIP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
981.0
|
0.98
|
STRING
|
36370105
|
BRCA2
|
PALB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
981.0
|
0.98
|
STRING
|
36370105
|
CDK6
|
CDKN2A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
981.0
|
0.98
|
STRING
|
36370105
|
PRKDC
|
XRCC6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
981.0
|
0.98
|
STRING
|
36370105
|
TERF2
|
TERF2IP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
981.0
|
0.98
|
STRING
|
36370105
|
CCNB1
|
CDK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
982.0
|
0.98
|
STRING
|
36370105
|
PRKDC
|
XRCC5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
982.0
|
0.98
|
STRING
|
36370105
|
ATRX
|
DAXX
|
â—¼ PHYSICAL_INTERACTION
|
|
|
983.0
|
0.98
|
STRING
|
36370105
|
CCND1
|
CDKN1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
983.0
|
0.98
|
STRING
|
36370105
|
EIF4EBP1
|
MTOR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
983.0
|
0.98
|
STRING
|
36370105
|
TP53
|
TP53BP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
983.0
|
0.98
|
STRING
|
36370105
|
MAP2K2
|
MAPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
984.0
|
0.98
|
STRING
|
36370105
|
PIK3CD
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
986.0
|
0.98
|
STRING
|
36370105
|
CCNA2
|
CDK2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.99
|
0.99
|
HIPPIE
|
8475101
28514442
16431923
33854235
11940657
10559988
15189033
17361108
16290148
14681455
17254966
8662825
25852190
15557281
23455922
19483727
18471975
11141566
10924145
15828833
21241890
19631451
11377199
18177895
8684460
26496610
9716181
12853968
11907280
23602568
9724724
15647383
14656438
19773423
12941338
15239650
24302728
25669885
15890360
7630397
8756328
8397207
21447625
22231403
20733051
9660939
24358021
12044161
33422522
11983168
33961781
26186194
7553852
16209941
12244298
9380407
8463339
15455144
10930425
|
TP53
|
MDM2
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.99
|
0.99
|
mint
|
17139261
5219401
|
MSH6
|
MSH2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.99
|
0.99
|
HIPPIE
|
19377479
25241761
10783165
8942985
9428522
10029069
26496610
10856833
14657349
10748159
33961781
9774676
22939629
26344197
15064730
|
RAD50
|
MRE11
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.99
|
0.99
|
HIPPIE
|
30179224
12607003
30733337
10888888
23530059
24651726
11062235
17694070
10783165
31501894
33558481
19197236
24413181
26455393
10508516
16163361
28369484
26215093
34038735
8756642
22939629
34348893
17500065
12750284
9705271
16391231
27173435
28363998
24981860
19270065
11504724
26344197
15734743
|
RFC2
|
RFC4
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.99
|
0.99
|
HIPPIE
|
9228079
9751713
28514442
9488738
22939629
8692848
15655353
33961781
24981860
16582606
9092549
26344197
|
MAPK14
|
MAPKAPK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
991.0
|
0.99
|
STRING
|
36370105
|
TOPBP1
|
TP53BP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
995.0
|
0.99
|
STRING
|
36370105
|
RFC1
|
RFC4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
996.0
|
0.99
|
STRING
|
36370105
|
RFC2
|
RFC4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
997.0
|
0.99
|
STRING
|
36370105
|
UBE2N
|
UBE2V2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
997.0
|
0.99
|
STRING
|
36370105
|
ACD
|
POT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
997.0
|
0.99
|
STRING
|
36370105
|
BARD1
|
BRCA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
CDK2
|
CDKN1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
EP300
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
MDM2
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
MDM2
|
MDM4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
MDM4
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
XRCC5
|
XRCC6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
MAPK1
|
APBB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
14697653
|
XRCC6
|
ATM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
22179609
11493912
9512523
11604075
12947387
|
BRCA1
|
ATM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
22021381
16153896
18923075
18805091
21325134
22792074
19419957
21052091
18971343
25122754
11301010
21240188
|
BLM
|
ATM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
22021381
16153896
18923075
18805091
21325134
22792074
19419957
21052091
18971343
25122754
11301010
21240188
|
XRCC5
|
ATM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
22179609
11493912
9512523
11604075
12947387
|
CDK2
|
ATM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
9781043
16322221
16123081
11292842
10928988
|
MLH1
|
ATM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
9781043
16322221
16123081
11292842
10928988
|
ATM
|
PAXIP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15468306
15574327
23333306
23306437
15723659
23727112
|
ATM
|
BARD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
22021381
16153896
18923075
18805091
21325134
22792074
19419957
21052091
18971343
25122754
11301010
21240188
|
ATM
|
MDC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
64.0
|
1.0
|
ACSN
|
11331603
11571274
11850621
11877377
12086603
12234250
12556884
12607003
14614141
14988723
15136767
15140942
15175241
15242590
15279786
15375219
15377654
15459660
15485915
15798197
15964794
16163361
16332722
16531125
16713580
16805667
16818604
16858402
17102137
17116885
17296725
17303408
17384638
17582221
17660363
18001824
18006705
18087292
18469862
18543256
18583988
18584027
18590585
18678890
18809224
18995830
19151707
19282663
19342888
19622404
19686080
19772495
19793801
20051983
20160076
20723763
21376743
22743550
23030059
23847781
24050180
7575488
9407949
9488723
|
ATM
|
RAD50
|
â—¼ PHYSICAL_INTERACTION
|
|
|
100.0
|
1.0
|
ACSN
|
11283614
11331603
11850621
11877377
12086603
12202749
12556884
12607003
14614141
14988723
15136767
15140942
15175241
15211575
15242590
15279786
15375219
15377654
15385537
15459660
15485915
15496928
15498778
15549137
15655342
15798197
15964794
16163361
16332722
16449207
16531125
16713580
16805667
16818604
16858402
17055429
17102137
17116323
17116885
17296725
17303408
17384638
17582221
17660363
17965729
18001825
18006705
18087292
18171670
18171986
18212739
18398454
18469862
18524993
18543256
18558713
18583988
18584027
18590585
18678890
18809224
18995830
19151707
19202191
19217833
19270065
19282663
19342888
19362533
19490890
19622404
19654615
19686080
19772495
19793801
19892829
20021983
20027199
20051983
20064462
20691907
20713526
20723763
21376743
2191300
22657828
22743550
23082994
23161013
23253856
23847781
24036544
24050180
24089143
24095737
24709898
7575488
9407949
9488723
9721205
|
ATM
|
BRIP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
22021381
16153896
18923075
18805091
21325134
22792074
19419957
21052091
18971343
25122754
11301010
21240188
|
ATM
|
MDC1
|
â—¼ SHARES_COMPLEX
|
|
|
64.0
|
1.0
|
ACSN
|
11331603
11571274
11850621
11877377
12086603
12234250
12556884
12607003
14614141
14988723
15136767
15140942
15175241
15242590
15279786
15375219
15377654
15459660
15485915
15798197
15964794
16163361
16332722
16531125
16713580
16805667
16818604
16858402
17102137
17116885
17296725
17303408
17384638
17582221
17660363
18001824
18006705
18087292
18469862
18543256
18583988
18584027
18590585
18678890
18809224
18995830
19151707
19282663
19342888
19622404
19686080
19772495
19793801
20051983
20160076
20723763
21376743
22743550
23030059
23847781
24050180
7575488
9407949
9488723
|
ATM
|
RAD50
|
â—¼ SHARES_COMPLEX
|
|
|
100.0
|
1.0
|
ACSN
|
11283614
11331603
11850621
11877377
12086603
12202749
12556884
12607003
14614141
14988723
15136767
15140942
15175241
15211575
15242590
15279786
15375219
15377654
15385537
15459660
15485915
15496928
15498778
15549137
15655342
15798197
15964794
16163361
16332722
16449207
16531125
16713580
16805667
16818604
16858402
17055429
17102137
17116323
17116885
17296725
17303408
17384638
17582221
17660363
17965729
18001825
18006705
18087292
18171670
18171986
18212739
18398454
18469862
18524993
18543256
18558713
18583988
18584027
18590585
18678890
18809224
18995830
19151707
19202191
19217833
19270065
19282663
19342888
19362533
19490890
19622404
19654615
19686080
19772495
19793801
19892829
20021983
20027199
20051983
20064462
20691907
20713526
20723763
21376743
2191300
22657828
22743550
23082994
23161013
23253856
23847781
24036544
24050180
24089143
24095737
24709898
7575488
9407949
9488723
9721205
|
ATM
|
BRCA1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
54.0
|
1.0
|
ACSN
|
11331603
11438669
11804596
11877377
12086603
12556884
12607003
14988723
15136767
15140942
15175241
15459660
15485915
15798197
15867354
15964794
16163361
16332722
16581787
16713580
16731533
16805667
16858402
17102137
17116885
17296725
17303408
17384638
17582221
17713585
18006705
18048416
18469862
18511906
18583988
18716619
18756267
18995830
19151707
19282663
19342888
19357644
19490890
19622404
19788416
19793801
19793861
19841479
20019063
20051983
21376743
23847781
9168117
9858600
|
ATM
|
CHEK1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
54.0
|
1.0
|
ACSN
|
11331603
11438669
11804596
11877377
12086603
12556884
12607003
14988723
15136767
15140942
15175241
15459660
15485915
15798197
15867354
15964794
16163361
16332722
16581787
16713580
16731533
16805667
16858402
17102137
17116885
17296725
17303408
17384638
17582221
17713585
18006705
18048416
18469862
18511906
18583988
18716619
18756267
18995830
19151707
19282663
19342888
19357644
19490890
19622404
19788416
19793801
19793861
19841479
20019063
20051983
21376743
23847781
9168117
9858600
|
ATM
|
CHEK2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
59.0
|
1.0
|
ACSN
|
11331603
11850621
11877377
12086603
12556884
12607003
14614141
14988723
15136767
15140942
15175241
15242590
15279786
15375219
15377654
15459660
15485915
15798197
15964794
16163361
16332722
16531125
16713580
16805667
16818604
16858402
17102137
17116885
17296725
17303408
17384638
17582221
17660363
18006705
18087292
18469862
18543256
18583988
18584027
18590585
18678890
18809224
18995830
19151707
19282663
19342888
19622404
19686080
19772495
19793801
20051983
20723763
21376743
22743550
23847781
24050180
7575488
9407949
9488723
|
ATM
|
MDC1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
64.0
|
1.0
|
ACSN
|
11331603
11571274
11850621
11877377
12086603
12234250
12556884
12607003
14614141
14988723
15136767
15140942
15175241
15242590
15279786
15375219
15377654
15459660
15485915
15798197
15964794
16163361
16332722
16531125
16713580
16805667
16818604
16858402
17102137
17116885
17296725
17303408
17384638
17582221
17660363
18001824
18006705
18087292
18469862
18543256
18583988
18584027
18590585
18678890
18809224
18995830
19151707
19282663
19342888
19622404
19686080
19772495
19793801
20051983
20160076
20723763
21376743
22743550
23030059
23847781
24050180
7575488
9407949
9488723
|
ATM
|
TERF1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
ACSN
|
11331603
11877377
12607003
15140942
15459660
15964794
16163361
17303408
22266654
22634377
23847781
|
ATM
|
MDM2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
54.0
|
1.0
|
ACSN
|
11331603
11438669
11804596
11877377
12086603
12556884
12607003
14988723
15136767
15140942
15175241
15459660
15485915
15798197
15867354
15964794
16163361
16332722
16581787
16713580
16731533
16805667
16858402
17102137
17116885
17296725
17303408
17384638
17582221
17713585
18006705
18048416
18469862
18511906
18583988
18716619
18756267
18995830
19151707
19282663
19342888
19357644
19490890
19622404
19788416
19793801
19793861
19841479
20019063
20051983
21376743
23847781
9168117
9858600
|
MSH2
|
ATM
|
â—¼ UP_REGULATES
|
✅
|
+
|
20.0
|
1.0
|
ACSN
|
12556884
12947387
15136767
15703371
16332722
16612326
16697054
16713580
16858402
17303408
18157157
18406444
18543256
19151707
19473888
19595721
19596235
19596236
19847258
20478261
|
MLH1
|
ATM
|
â—¼ UP_REGULATES
|
✅
|
+
|
16.0
|
1.0
|
ACSN
|
12556884
15136767
15703371
16332722
16612326
16697054
16713580
16858402
17303408
17581638
18157157
18406444
18543256
19151707
19847258
20478261
|
MSH6
|
ATM
|
â—¼ UP_REGULATES
|
✅
|
+
|
20.0
|
1.0
|
ACSN
|
12556884
12947387
15136767
15703371
16332722
16612326
16697054
16713580
16858402
17303408
18157157
18406444
18543256
19151707
19473888
19595721
19596235
19596236
19847258
20478261
|
PPP5C
|
ATM
|
â—¼ REGULATES
|
✅
|
|
27.0
|
1.0
|
ACSN
|
12086603
12556884
14871926
14988723
15136767
15175241
15459660
15798197
16260606
16332722
16713580
16805667
16858402
17102137
17116885
17296725
17303408
17384638
17582221
18469862
18995830
19151707
19282663
19342888
19622404
19793801
20051983
|
ATM
|
MDC1
|
â—¼ REGULATES
|
✅
|
|
64.0
|
1.0
|
ACSN
|
11331603
11571274
11850621
11877377
12086603
12234250
12556884
12607003
14614141
14988723
15136767
15140942
15175241
15242590
15279786
15375219
15377654
15459660
15485915
15798197
15964794
16163361
16332722
16531125
16713580
16805667
16818604
16858402
17102137
17116885
17296725
17303408
17384638
17582221
17660363
18001824
18006705
18087292
18469862
18543256
18583988
18584027
18590585
18678890
18809224
18995830
19151707
19282663
19342888
19622404
19686080
19772495
19793801
20051983
20160076
20723763
21376743
22743550
23030059
23847781
24050180
7575488
9407949
9488723
|
ATM
|
RAD50
|
â—¼ REGULATES
|
✅
|
|
100.0
|
1.0
|
ACSN
|
11283614
11331603
11850621
11877377
12086603
12202749
12556884
12607003
14614141
14988723
15136767
15140942
15175241
15211575
15242590
15279786
15375219
15377654
15385537
15459660
15485915
15496928
15498778
15549137
15655342
15798197
15964794
16163361
16332722
16449207
16531125
16713580
16805667
16818604
16858402
17055429
17102137
17116323
17116885
17296725
17303408
17384638
17582221
17660363
17965729
18001825
18006705
18087292
18171670
18171986
18212739
18398454
18469862
18524993
18543256
18558713
18583988
18584027
18590585
18678890
18809224
18995830
19151707
19202191
19217833
19270065
19282663
19342888
19362533
19490890
19622404
19654615
19686080
19772495
19793801
19892829
20021983
20027199
20051983
20064462
20691907
20713526
20723763
21376743
2191300
22657828
22743550
23082994
23161013
23253856
23847781
24036544
24050180
24089143
24095737
24709898
7575488
9407949
9488723
9721205
|
AURKB
|
ATM
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
22099307
27493659
|
PPP5C
|
ATM
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
18772547
17376776
17303408
16858402
19151707
14871926
16260606
16332722
12556884
15459660
|
PAXIP1
|
ATM
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
15456759
19414588
17690115
|
ATR
|
ATM
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
15510216
10608806
17478428
17124492
|
ATM
|
DCLRE1C
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
15723659
25842165
15574327
15456891
16874298
15468306
|
ATM
|
E2F1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
22.0
|
1.0
|
Omnipath
|
20972224
11459832
27679857
15494392
15140942
27028861
21543892
27025900
20860841
24741006
17570479
25101673
28812991
15838517
22174788
|
ATM
|
TERF2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
16223874
17525332
15314656
|
ATM
|
EP300
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
20471956
15494392
15140942
29590107
26170237
21108945
15838517
27220480
|
ATM
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
452.0
|
1.0
|
Omnipath
|
25301947
21720806
23549171
10713094
16501611
15077171
24886358
17570479
19375142
22028490
16916644
14712210
19303885
9407038
11927276
26700820
28356518
15226429
10723129
19788889
12064478
19705844
26673821
22179422
20931131
19062161
27030982
22891162
17157788
19056039
15758953
12049739
15361830
26620371
25865756
22615843
10196661
10656682
11313957
25088203
15140942
12519769
16319535
24469230
12776195
17234789
27511909
29238697
24608431
12927814
16783362
11875057
16436515
22778557
15181149
12702572
10500142
15178764
28842590
28145533
11591448
17855337
22726545
20206688
26824362
21317290
26104798
24704793
9765199
11314044
16906133
17174997
21593792
17967874
10771484
15585169
19625493
15178448
17596534
16288207
15048074
18353733
24057508
19535302
29344296
23708100
29872395
23705030
25043304
33761896
18431490
21404020
15024084
22559321
12151394
24078877
12080066
33982778
16893723
10958792
18289945
27183917
26337656
29170437
18765533
10744722
21748595
18056442
24820418
15489892
16390936
24086335
28140789
23091651
34523970
32001619
23418564
15279808
21317932
21188172
27559048
16818505
17616578
11551930
19010925
11709713
24711418
28654064
18339864
11173129
17486112
10570149
29774100
18381438
21994612
29558908
15258567
9372954
25860929
16858402
33692124
15775976
34107253
19923893
24958101
10436023
14752509
19962312
19071090
26438152
26093282
20123963
22444248
9843217
17525332
15456784
23533526
11780126
20353948
29290977
11096068
28102346
18855897
20372057
24395704
23890999
15725625
15806145
34103468
18345031
16997395
16293623
28477117
19828454
27630139
12071847
22002314
21315088
27177180
12645530
12890678
26113041
15794754
18560558
22099307
9885574
28903382
15665826
24877058
18332866
10611322
24380814
14871840
19934315
22975381
16489034
18406507
21440540
33687951
10608806
23892398
20730097
16914171
15782130
15177184
22055193
18490454
25867001
24349352
18045533
20663147
17535811
20506250
23982736
22375140
15700044
15279774
19266268
24358288
18697815
14729946
20637859
12242661
12771937
17371838
31940492
19409520
10528155
24037342
17257427
11121242
15310764
23148227
28915641
26928575
21423215
11865061
16949371
27810895
18449195
20711232
27389279
22213803
16713569
10446957
22797063
16478990
29048667
15489221
17241873
21187893
21441950
23907539
20005840
9733514
26244501
21614094
12082529
10467728
10714958
32061892
16636671
29147215
10673501
12091386
25202122
21465263
19544417
25823026
24078903
24038750
22198295
21480565
15177039
28182994
28208785
18674635
20183804
18818083
9925639
17712528
15254178
11483158
27940348
26675349
26261212
19717643
12606585
24559687
14871926
23150668
21329876
28153791
12518062
12767922
23824039
11711532
19251701
28118604
15078887
12393500
17456577
20976220
23380594
12519780
20810927
15533933
22420423
17108107
20145032
18032786
18785202
22037398
23184057
31968249
16729035
12588868
21614932
11546806
18614045
14757188
15029243
14968111
22649771
25512053
34496248
18604166
17609585
17976513
16223874
25433195
18985806
9363941
15159397
34282274
29301278
24505404
26056062
23577291
18272544
18715874
19536869
29334356
10801407
15155458
25201202
24376853
19907922
23525106
14643431
28340339
28051100
19085961
15212693
22201816
20026654
16322229
20080565
9733515
15632067
18672098
22577550
25691451
12637545
12548019
11672523
26984736
12324477
16552184
22084686
10864201
14744854
21532626
17118344
19482562
9561848
12511424
17668048
23358251
18511169
21460853
22022355
12939400
21415014
17292432
25651062
23168260
12111733
16648554
30361254
23678107
|
ATM
|
NBN
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
80.0
|
1.0
|
Omnipath
|
12433983
12861053
17485521
23146902
10839545
19413330
15302935
27602502
17429352
19523210
24360018
20068231
17507690
17570479
10608806
12598907
18669648
25088203
18003706
11252893
17431132
23097684
10766245
12814430
10802669
21664921
26512707
10839544
11927276
21130714
17525332
12447395
14707289
15733840
15279770
25119968
18644472
28822740
|
ATM
|
TP53BP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
34.0
|
1.0
|
Omnipath
|
11042216
17940005
26247731
18996087
19876065
16945145
12447390
22621922
18644834
19650866
24320053
18077418
17570479
17690115
17525332
12697768
|
ATM
|
TOPBP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
11756551
18077418
19279141
17525332
17446169
|
ATM
|
EIF4EBP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
31.0
|
1.0
|
Omnipath
|
9806882
17525332
10713094
21315178
17570479
26777338
10608806
11146653
12588975
18212344
29152614
|
ATM
|
BLM
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
23.0
|
1.0
|
Omnipath
|
16199871
11146546
25766002
17984114
14643436
20719863
17363339
14729972
18054789
12034743
30496191
16880735
11375976
|
ATM
|
CHEK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
176.0
|
1.0
|
Omnipath
|
26683224
17303408
28852018
10713094
20080130
27545311
9488723
15342622
23941746
26485758
28937603
15279786
24882580
10744722
15125777
25746763
18583988
28051860
17570479
16531125
21329876
23892398
19607708
16940182
26643553
20396397
28259974
25361978
17660363
15459660
19375317
25247188
16311512
23118481
20498628
22030216
25613496
22420423
9407949
17918214
12493754
20859824
26158765
15700044
27558808
11901158
27602502
20637859
16163361
20599567
23638118
16481012
12242661
23847781
12024051
15140942
11728459
12454775
16936775
25450480
28950914
26295265
20160490
22319212
24349411
18006705
20723763
18678890
12805407
20860841
23386996
24050180
11668173
27271602
29304495
12447382
24798733
9889122
23347679
18794134
21147465
21421565
26516160
17715138
21376743
19440053
12773400
10973490
17174984
26442630
15694385
11877377
29022904
18809224
11850621
18787700
12718885
19481982
22743550
20372057
15212693
16085488
19101576
29555944
25954303
24473398
18087292
16794575
24492479
24244353
19793801
25404613
21102523
29156743
23253087
16997395
7575488
25808488
20647331
18584027
21851590
21315088
23705030
15629715
29741650
21772273
11025670
18590585
26610585
15964794
29434792
20068082
23006513
19881958
19230643
12607003
24769180
25249630
15024084
19772495
25714019
18603484
25173936
23666059
19473886
27568553
22808196
|
ATM
|
DAXX
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
23405218
17525332
25659035
|
ATM
|
NABP2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
25249620
26170237
28448822
21051358
18449195
23178594
|
ATM
|
PRKDC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
47.0
|
1.0
|
Omnipath
|
17189255
12231622
17303408
24492479
10464290
22230547
15677476
16822724
28985363
29088817
16163361
32868446
19549901
25818648
22923485
19103741
17570479
27939942
19808981
23847781
22355272
24714417
15964794
21376743
31983282
25224041
16908529
12607003
19244120
17525332
15459660
34249431
28107384
12186630
25714019
11877377
26553138
27568553
19535303
15507430
26578593
|
ATM
|
MDM2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
66.0
|
1.0
|
Omnipath
|
14654783
12383858
17936559
20651945
17303408
19816404
10611322
23150762
23277204
23386996
26416444
27258263
23002429
11331603
15865937
21556066
16163361
23708100
17570479
20514355
22264782
27177180
18265945
28690977
23847781
22264786
15140942
15964794
19788416
22624716
25201202
27462439
12607003
28050229
32350255
22649771
27956626
15459660
22976441
25247188
28904407
11877377
21859827
24534650
23405218
29290977
27568562
|
ATM
|
MRE11
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
19709933
26240375
17570479
31353207
10608806
|
ATM
|
MDM4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
25.0
|
1.0
|
Omnipath
|
20651945
16943424
29065514
16511560
20860841
28690977
17512070
23002429
16163388
16082221
28096294
15788536
|
ATM
|
RBBP8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
26.0
|
1.0
|
Omnipath
|
23468639
23675572
17570479
24837676
10910365
16249056
11689934
10608806
17525332
22743550
|
ATM
|
TERF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
24.0
|
1.0
|
Omnipath
|
17145710
17717821
15314656
17570479
23732473
26586433
11375976
22266654
|
ATM
|
CHEK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
69.0
|
1.0
|
Omnipath
|
29774099
20976184
26683224
25663895
12676583
17303408
14657349
29167438
27545311
10859164
19056039
15485915
28808226
12588868
16163361
15650047
12676962
17570479
14988723
14681223
26516160
10608806
26069190
29741650
12676925
23847781
17118344
11252893
20376879
15964794
15149599
18691976
19059218
20068082
15707391
12607003
25450480
17525332
11553781
19646247
15870257
15459660
20798862
19716789
11877377
12660173
11390642
15674326
16782033
28396830
28228262
12446774
15533933
15212693
29555944
|
ATM
|
BRCA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
79.0
|
1.0
|
Omnipath
|
26927092
17303408
15159397
24746700
12024016
10866324
30197789
12919958
11114888
26745677
26383678
34301763
12427729
11313470
16163361
28035057
20068231
25939603
26320175
17570479
19683496
22743550
10608806
23802008
23847781
21203981
15964794
12183412
12607003
17525332
19996295
15459660
11278964
19651622
21706030
11877377
20952512
10373534
19622773
10550055
27170701
15212693
23704879
|
ATM
|
RAD50
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
17570479
17081983
15302935
|
ATM
|
MDC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
17145710
28193847
21705321
22234877
12607003
12607005
22234878
17525332
18006705
|
ATR
|
ATRIP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
61.0
|
1.0
|
ACSN
|
10884395
11756412
11877377
12086603
12466554
12766152
12875843
14614141
14624239
14657033
14726013
14988723
15136767
15175241
15189446
15242590
15375219
15377654
15459660
15485915
15703371
15743907
15798197
16530042
16697054
16713580
16805667
16818604
16880517
16885023
16934469
17035102
17102137
17116885
17141802
17296725
17303408
17384638
17582221
17855402
18157158
18451105
18469862
18543256
18677104
18931676
18995830
19158510
19217833
19225445
19258535
19282663
19342888
19622404
19686080
1974050
19793801
19847258
20051983
22021614
23414611
|
ATR
|
CHEK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
52.0
|
1.0
|
ACSN
|
11756412
11877377
12086603
12466554
12766152
12875843
14624239
14657033
14726013
14988723
15136767
15175241
15189446
15459660
15485915
15703371
15798197
16530042
16697054
16713580
16805667
16880517
16885023
16934469
17035102
17102137
17116885
17141802
17296725
17303408
17384638
17582221
18157158
18451105
18469862
18677104
18931676
18995830
19158510
19217833
19225445
19258535
19282663
19342888
19622404
19686080
1974050
19793801
19847258
20051983
22021614
23414611
|
ATR
|
RAD50
|
â—¼ PHYSICAL_INTERACTION
|
|
|
36.0
|
1.0
|
ACSN
|
11850621
11877377
12086603
12607003
14988723
15136767
15175241
15459660
15798197
16713580
16805667
17102137
17116885
17296725
17384638
17582221
18087292
18469862
18584027
18677104
18809224
18931676
18995830
19282663
19342888
19622404
19686080
19772495
19793801
20051983
20723763
21376743
22743550
22751496
23444773
24050180
|
ATR
|
MCM5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
43.0
|
1.0
|
ACSN
|
10884395
11877377
11900249
12086603
12648680
12766152
12875843
14624239
14726013
14988723
15136767
15175241
15459660
15703371
15798197
16697054
16713580
16805667
16880517
16885023
16934469
17102137
17116885
17141802
17296725
17303408
17384638
17493829
17582221
17884153
18469862
18677104
18995830
19282663
19342888
19622404
19793801
19809470
19847258
20051983
20478261
8943031
9524127
|
ATR
|
RAD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
38.0
|
1.0
|
ACSN
|
10884395
11877377
12086603
12766152
14726013
14988723
15136767
15175241
15459660
15485915
15703371
15798197
16530042
16697054
16713580
16805667
16880517
16885023
16934469
17102137
17116885
17296725
17303408
17384638
17493829
17582221
18469862
18677104
18995830
19282663
19342888
19622404
19793801
19847258
20051983
20478261
8943031
9524127
|
ATR
|
TOPBP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
19.0
|
1.0
|
ACSN
|
11877377
12766152
15459660
15485915
15798197
16530042
16880517
16885023
16934469
17102137
17116885
17296725
17303408
17384638
17582221
18677104
19282663
19622404
19793801
|
ATR
|
RAD1
|
â—¼ SHARES_COMPLEX
|
|
|
38.0
|
1.0
|
ACSN
|
10884395
11877377
12086603
12766152
14726013
14988723
15136767
15175241
15459660
15485915
15703371
15798197
16530042
16697054
16713580
16805667
16880517
16885023
16934469
17102137
17116885
17296725
17303408
17384638
17493829
17582221
18469862
18677104
18995830
19282663
19342888
19622404
19793801
19847258
20051983
20478261
8943031
9524127
|
ATR
|
ATRIP
|
â—¼ SHARES_COMPLEX
|
|
|
61.0
|
1.0
|
ACSN
|
10884395
11756412
11877377
12086603
12466554
12766152
12875843
14614141
14624239
14657033
14726013
14988723
15136767
15175241
15189446
15242590
15375219
15377654
15459660
15485915
15703371
15743907
15798197
16530042
16697054
16713580
16805667
16818604
16880517
16885023
16934469
17035102
17102137
17116885
17141802
17296725
17303408
17384638
17582221
17855402
18157158
18451105
18469862
18543256
18677104
18931676
18995830
19158510
19217833
19225445
19258535
19282663
19342888
19622404
19686080
1974050
19793801
19847258
20051983
22021614
23414611
|
ATR
|
CHEK1
|
â—¼ SHARES_COMPLEX
|
|
|
52.0
|
1.0
|
ACSN
|
11756412
11877377
12086603
12466554
12766152
12875843
14624239
14657033
14726013
14988723
15136767
15175241
15189446
15459660
15485915
15703371
15798197
16530042
16697054
16713580
16805667
16880517
16885023
16934469
17035102
17102137
17116885
17141802
17296725
17303408
17384638
17582221
18157158
18451105
18469862
18677104
18931676
18995830
19158510
19217833
19225445
19258535
19282663
19342888
19622404
19686080
1974050
19793801
19847258
20051983
22021614
23414611
|
ATR
|
TOPBP1
|
â—¼ SHARES_COMPLEX
|
|
|
19.0
|
1.0
|
ACSN
|
11877377
12766152
15459660
15485915
15798197
16530042
16880517
16885023
16934469
17102137
17116885
17296725
17303408
17384638
17582221
18677104
19282663
19622404
19793801
|
ATR
|
RAD50
|
â—¼ SHARES_COMPLEX
|
|
|
36.0
|
1.0
|
ACSN
|
11850621
11877377
12086603
12607003
14988723
15136767
15175241
15459660
15798197
16713580
16805667
17102137
17116885
17296725
17384638
17582221
18087292
18469862
18584027
18677104
18809224
18931676
18995830
19282663
19342888
19622404
19686080
19772495
19793801
20051983
20723763
21376743
22743550
22751496
23444773
24050180
|
MSH2
|
ATR
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
20.0
|
1.0
|
ACSN
|
12556884
12947387
15136767
15703371
16332722
16612326
16697054
16713580
16858402
17303408
18157157
18406444
18543256
19151707
19473888
19595721
19596235
19596236
19847258
20478261
|
MSH6
|
ATR
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
20.0
|
1.0
|
ACSN
|
12556884
12947387
15136767
15703371
16332722
16612326
16697054
16713580
16858402
17303408
18157157
18406444
18543256
19151707
19473888
19595721
19596235
19596236
19847258
20478261
|
MLH1
|
ATR
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
16.0
|
1.0
|
ACSN
|
12556884
15136767
15703371
16332722
16612326
16697054
16713580
16858402
17303408
17581638
18157157
18406444
18543256
19151707
19847258
20478261
|
ATR
|
MDM2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
42.0
|
1.0
|
ACSN
|
11438669
11877377
14988723
15136767
15459660
15485915
15798197
15867354
16332722
16540648
16713580
16731533
16885023
17102137
17116885
17296725
17303408
17384638
17582221
18048416
18511906
18543256
18677104
18716619
18756267
18931676
18995830
19004803
19282663
19357644
19490890
19622404
19686080
19772495
19788416
19793801
19793861
19841479
20019063
20051983
9488723
9858600
|
ATR
|
CHEK1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
52.0
|
1.0
|
ACSN
|
11756412
11877377
12086603
12466554
12766152
12875843
14624239
14657033
14726013
14988723
15136767
15175241
15189446
15459660
15485915
15703371
15798197
16530042
16697054
16713580
16805667
16880517
16885023
16934469
17035102
17102137
17116885
17141802
17296725
17303408
17384638
17582221
18157158
18451105
18469862
18677104
18931676
18995830
19158510
19217833
19225445
19258535
19282663
19342888
19622404
19686080
1974050
19793801
19847258
20051983
22021614
23414611
|
ATR
|
RAD1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
38.0
|
1.0
|
ACSN
|
10884395
11877377
12086603
12766152
14726013
14988723
15136767
15175241
15459660
15485915
15703371
15798197
16530042
16697054
16713580
16805667
16880517
16885023
16934469
17102137
17116885
17296725
17303408
17384638
17493829
17582221
18469862
18677104
18995830
19282663
19342888
19622404
19793801
19847258
20051983
20478261
8943031
9524127
|
ATR
|
BRCA1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
42.0
|
1.0
|
ACSN
|
11438669
11877377
14988723
15136767
15459660
15485915
15798197
15867354
16332722
16540648
16713580
16731533
16885023
17102137
17116885
17296725
17303408
17384638
17582221
18048416
18511906
18543256
18677104
18716619
18756267
18931676
18995830
19004803
19282663
19357644
19490890
19622404
19686080
19772495
19788416
19793801
19793861
19841479
20019063
20051983
9488723
9858600
|
ATR
|
CHEK2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
42.0
|
1.0
|
ACSN
|
11438669
11877377
14988723
15136767
15459660
15485915
15798197
15867354
16332722
16540648
16713580
16731533
16885023
17102137
17116885
17296725
17303408
17384638
17582221
18048416
18511906
18543256
18677104
18716619
18756267
18931676
18995830
19004803
19282663
19357644
19490890
19622404
19686080
19772495
19788416
19793801
19793861
19841479
20019063
20051983
9488723
9858600
|
ATR
|
MCM5
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
43.0
|
1.0
|
ACSN
|
10884395
11877377
11900249
12086603
12648680
12766152
12875843
14624239
14726013
14988723
15136767
15175241
15459660
15703371
15798197
16697054
16713580
16805667
16880517
16885023
16934469
17102137
17116885
17141802
17296725
17303408
17384638
17493829
17582221
17884153
18469862
18677104
18995830
19282663
19342888
19622404
19793801
19809470
19847258
20051983
20478261
8943031
9524127
|
BLM
|
ATR
|
â—¼ UP_REGULATES
|
✅
|
+
|
35.0
|
1.0
|
ACSN
|
12239151
12466554
12535671
12972610
14657033
14988723
15136767
15189446
16337602
16697054
17035102
18157158
18448394
18469862
18472307
18550849
18931676
19217833
19225445
19258535
19282663
19622404
19686080
19772495
19847258
20832754
21948210
22266823
22615860
22657828
23253856
23444773
24089143
24095737
8020957
|
ATR
|
RAD1
|
â—¼ UP_REGULATES
|
✅
|
|
38.0
|
1.0
|
ACSN
|
10884395
11877377
12086603
12766152
14726013
14988723
15136767
15175241
15459660
15485915
15703371
15798197
16530042
16697054
16713580
16805667
16880517
16885023
16934469
17102137
17116885
17296725
17303408
17384638
17493829
17582221
18469862
18677104
18995830
19282663
19342888
19622404
19793801
19847258
20051983
20478261
8943031
9524127
|
ATR
|
MCM5
|
â—¼ REGULATES
|
✅
|
|
43.0
|
1.0
|
ACSN
|
10884395
11877377
11900249
12086603
12648680
12766152
12875843
14624239
14726013
14988723
15136767
15175241
15459660
15703371
15798197
16697054
16713580
16805667
16880517
16885023
16934469
17102137
17116885
17141802
17296725
17303408
17384638
17493829
17582221
17884153
18469862
18677104
18995830
19282663
19342888
19622404
19793801
19809470
19847258
20051983
20478261
8943031
9524127
|
MSH2
|
ATR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
23.0
|
1.0
|
Omnipath
|
19847258
16612326
14657349
16713580
20478261
15703371
18543256
12947387
19473888
19595721
19596235
18157157
16697054
19596236
18406444
21285353
|
TOPBP1
|
ATR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
16530042
18769153
16285702
18066086
|
ATR
|
BRCA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
54.0
|
1.0
|
Omnipath
|
26927092
17478428
24746700
15159397
17531442
10866324
18677104
19622404
15798197
19793801
20860841
16713569
11114888
23422745
20936109
16322207
19282663
20068231
17116885
17582221
25879655
10608806
17384638
23346553
12773400
12183412
17525332
15459660
11278964
17296725
11877377
17102137
10550055
16522651
|
ATR
|
CHEK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
38.0
|
1.0
|
Omnipath
|
21722802
20859824
26683224
18677104
19622404
15798197
19793801
27545311
23137030
19836377
20647331
20599567
19282663
19658174
17116885
16481012
17582221
11715017
17384638
29741650
12024051
18802408
10973490
9857181
26442630
15459660
17296725
11877377
17102137
12493754
|
ATR
|
RBBP8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
25.0
|
1.0
|
Omnipath
|
18677104
19622404
15798197
19793801
15485915
24842372
20051983
19282663
17116885
17582221
17384638
23273981
18511906
18716619
19490890
15459660
30135856
19357644
17296725
11877377
17102137
25956864
|
ATR
|
PRKDC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
12186630
22592045
22057367
24500207
18077418
16908529
15507430
29309644
|
ATR
|
MDM2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
19.0
|
1.0
|
Omnipath
|
14654783
17296725
20651945
11877377
19788416
18677104
19282663
15798197
17102137
17116885
17582221
19622404
19793801
17384638
15459660
|
ATR
|
ATRIP
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
20616048
15451423
19889979
23144622
17686975
18344416
|
ATR
|
E2F1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
22.0
|
1.0
|
Omnipath
|
22184068
11459832
15494392
15140942
26843428
27028861
20413589
27025900
24741006
23202967
25101673
27903963
27827925
15838517
22174788
|
ATR
|
NBN
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
17715134
15758953
17526493
18077418
|
ATR
|
CHEK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
232.0
|
1.0
|
Omnipath
|
29774099
26683224
26658951
28180282
27545311
29605721
16461339
26165835
24971543
28937603
28573382
27713304
27643582
18723495
26082189
25205668
29088070
22971344
20536192
22353182
28051860
19276361
14681223
14988723
26069190
23892398
12676925
11252893
26643553
16520097
23383325
20396397
16431910
19059218
21440578
22357623
24753408
28572758
11090622
25795119
29309644
15870257
34398682
19716789
23508805
25965828
24947324
23380594
19071136
23118481
28396830
15533933
15190204
19737971
24023735
27283761
28025997
23696651
16360315
28915668
15707569
19062161
14657349
19489726
21937510
25448276
26721387
27558808
25104095
19056039
23468519
17081992
20679434
20062519
28808226
27679857
12588868
22203733
29928473
25459351
28558031
12766152
26748709
28986587
18265945
18669648
27775084
18691976
12781359
23583268
29221122
26633513
34509474
22564734
31928997
33863777
27685627
27167194
29118324
30796221
24366029
11390642
21907702
24632611
27068998
24349411
31591366
17686975
15665856
19781914
21736880
12676583
27690219
23386996
21482692
24113549
21730979
15775976
15272308
17851138
33811702
27271602
30510197
28273450
29209046
23849791
18794134
25024738
12676962
26438152
20932473
15279789
20376879
16414131
15149599
24387336
18790091
24327542
17525332
19646247
23997120
20798862
29022904
15674326
24500207
16137618
12446774
16885021
20639859
19101576
20976184
25663895
24244353
27603133
10859164
23333305
24621867
22863316
24072747
15650047
22084686
10859163
21851590
23613359
15629715
29741650
17118344
22706734
25565400
25301724
17327276
23006513
29242514
24906880
15707391
27908669
18353973
27708213
18243098
18603484
12660173
18955550
26039276
19473886
28255082
25898113
29163782
16629900
25937999
30100999
24140082
24970150
22084169
|
ATR
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
106.0
|
1.0
|
Omnipath
|
17145710
22778941
24395704
28468838
12401524
15159397
24877058
15254178
9733515
11483158
15806145
19056039
11875057
15865930
11551930
11883897
19923893
12548019
18697815
29170437
16293623
19010925
11709713
10446957
9363941
21748595
17272272
22797063
12242661
10196661
22084686
10747897
10608806
10673501
12091386
17118344
23892398
9765199
15489221
24037342
15140942
10435622
17241873
10597277
10801407
11711532
17174997
21593792
25201202
9843217
10606744
15024084
15226429
15922368
21415014
21480565
15585169
24947324
9925639
23380594
9733514
11865061
19625493
16390936
10951572
10570149
23311997
12111733
26144601
|
ATR
|
WDHD1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
27940552
26082189
|
ATRIP
|
CHEK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
52.0
|
1.0
|
ACSN
|
11756412
11877377
12086603
12466554
12766152
12875843
14624239
14657033
14726013
14988723
15136767
15175241
15189446
15459660
15485915
15703371
15798197
16530042
16697054
16713580
16805667
16880517
16885023
16934469
17035102
17102137
17116885
17141802
17296725
17303408
17384638
17582221
18157158
18451105
18469862
18677104
18931676
18995830
19158510
19217833
19225445
19258535
19282663
19342888
19622404
19686080
1974050
19793801
19847258
20051983
22021614
23414611
|
ATRIP
|
TOPBP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
19.0
|
1.0
|
ACSN
|
11877377
12766152
15459660
15485915
15798197
16530042
16880517
16885023
16934469
17102137
17116885
17296725
17303408
17384638
17582221
18677104
19282663
19622404
19793801
|
ATRIP
|
MCM5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
43.0
|
1.0
|
ACSN
|
10884395
11877377
11900249
12086603
12648680
12766152
12875843
14624239
14726013
14988723
15136767
15175241
15459660
15703371
15798197
16697054
16713580
16805667
16880517
16885023
16934469
17102137
17116885
17141802
17296725
17303408
17384638
17493829
17582221
17884153
18469862
18677104
18995830
19282663
19342888
19622404
19793801
19809470
19847258
20051983
20478261
8943031
9524127
|
ATRIP
|
RAD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
38.0
|
1.0
|
ACSN
|
10884395
11877377
12086603
12766152
14726013
14988723
15136767
15175241
15459660
15485915
15703371
15798197
16530042
16697054
16713580
16805667
16880517
16885023
16934469
17102137
17116885
17296725
17303408
17384638
17493829
17582221
18469862
18677104
18995830
19282663
19342888
19622404
19793801
19847258
20051983
20478261
8943031
9524127
|
ATRIP
|
RAD1
|
â—¼ SHARES_COMPLEX
|
|
|
38.0
|
1.0
|
ACSN
|
10884395
11877377
12086603
12766152
14726013
14988723
15136767
15175241
15459660
15485915
15703371
15798197
16530042
16697054
16713580
16805667
16880517
16885023
16934469
17102137
17116885
17296725
17303408
17384638
17493829
17582221
18469862
18677104
18995830
19282663
19342888
19622404
19793801
19847258
20051983
20478261
8943031
9524127
|
ATRIP
|
CHEK1
|
â—¼ SHARES_COMPLEX
|
|
|
52.0
|
1.0
|
ACSN
|
11756412
11877377
12086603
12466554
12766152
12875843
14624239
14657033
14726013
14988723
15136767
15175241
15189446
15459660
15485915
15703371
15798197
16530042
16697054
16713580
16805667
16880517
16885023
16934469
17035102
17102137
17116885
17141802
17296725
17303408
17384638
17582221
18157158
18451105
18469862
18677104
18931676
18995830
19158510
19217833
19225445
19258535
19282663
19342888
19622404
19686080
1974050
19793801
19847258
20051983
22021614
23414611
|
ATRIP
|
TOPBP1
|
â—¼ SHARES_COMPLEX
|
|
|
19.0
|
1.0
|
ACSN
|
11877377
12766152
15459660
15485915
15798197
16530042
16880517
16885023
16934469
17102137
17116885
17296725
17303408
17384638
17582221
18677104
19282663
19622404
19793801
|
MSH6
|
ATRIP
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
20.0
|
1.0
|
ACSN
|
12556884
12947387
15136767
15703371
16332722
16612326
16697054
16713580
16858402
17303408
18157157
18406444
18543256
19151707
19473888
19595721
19596235
19596236
19847258
20478261
|
MSH2
|
ATRIP
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
20.0
|
1.0
|
ACSN
|
12556884
12947387
15136767
15703371
16332722
16612326
16697054
16713580
16858402
17303408
18157157
18406444
18543256
19151707
19473888
19595721
19596235
19596236
19847258
20478261
|
MLH1
|
ATRIP
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
16.0
|
1.0
|
ACSN
|
12556884
15136767
15703371
16332722
16612326
16697054
16713580
16858402
17303408
17581638
18157157
18406444
18543256
19151707
19847258
20478261
|
ATRIP
|
RAD1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
38.0
|
1.0
|
ACSN
|
10884395
11877377
12086603
12766152
14726013
14988723
15136767
15175241
15459660
15485915
15703371
15798197
16530042
16697054
16713580
16805667
16880517
16885023
16934469
17102137
17116885
17296725
17303408
17384638
17493829
17582221
18469862
18677104
18995830
19282663
19342888
19622404
19793801
19847258
20051983
20478261
8943031
9524127
|
ATRIP
|
CHEK1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
52.0
|
1.0
|
ACSN
|
11756412
11877377
12086603
12466554
12766152
12875843
14624239
14657033
14726013
14988723
15136767
15175241
15189446
15459660
15485915
15703371
15798197
16530042
16697054
16713580
16805667
16880517
16885023
16934469
17035102
17102137
17116885
17141802
17296725
17303408
17384638
17582221
18157158
18451105
18469862
18677104
18931676
18995830
19158510
19217833
19225445
19258535
19282663
19342888
19622404
19686080
1974050
19793801
19847258
20051983
22021614
23414611
|
ATRIP
|
MCM5
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
43.0
|
1.0
|
ACSN
|
10884395
11877377
11900249
12086603
12648680
12766152
12875843
14624239
14726013
14988723
15136767
15175241
15459660
15703371
15798197
16697054
16713580
16805667
16880517
16885023
16934469
17102137
17116885
17141802
17296725
17303408
17384638
17493829
17582221
17884153
18469862
18677104
18995830
19282663
19342888
19622404
19793801
19809470
19847258
20051983
20478261
8943031
9524127
|
ATRIP
|
RAD1
|
â—¼ UP_REGULATES
|
✅
|
|
38.0
|
1.0
|
ACSN
|
10884395
11877377
12086603
12766152
14726013
14988723
15136767
15175241
15459660
15485915
15703371
15798197
16530042
16697054
16713580
16805667
16880517
16885023
16934469
17102137
17116885
17296725
17303408
17384638
17493829
17582221
18469862
18677104
18995830
19282663
19342888
19622404
19793801
19847258
20051983
20478261
8943031
9524127
|
ATRIP
|
MCM5
|
â—¼ REGULATES
|
✅
|
|
43.0
|
1.0
|
ACSN
|
10884395
11877377
11900249
12086603
12648680
12766152
12875843
14624239
14726013
14988723
15136767
15175241
15459660
15703371
15798197
16697054
16713580
16805667
16880517
16885023
16934469
17102137
17116885
17141802
17296725
17303408
17384638
17493829
17582221
17884153
18469862
18677104
18995830
19282663
19342888
19622404
19793801
19809470
19847258
20051983
20478261
8943031
9524127
|
CDK2
|
ATRIP
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
20195506
17638878
|
ATRIP
|
BRCA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
24073851
17616665
|
MRE11
|
BLM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
22021381
16153896
18923075
18805091
21325134
22792074
19419957
21052091
18971343
25122754
11301010
21240188
|
NBN
|
BLM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
22021381
16153896
18923075
18805091
21325134
22792074
19419957
21052091
18971343
25122754
11301010
21240188
|
BRCA1
|
BLM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
22021381
16153896
18923075
18805091
21325134
22792074
19419957
21052091
18971343
25122754
11301010
21240188
|
BLM
|
KAT5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
22021381
16153896
18923075
18805091
21325134
22792074
19419957
21052091
18971343
25122754
11301010
21240188
|
BLM
|
BARD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
22021381
16153896
18923075
18805091
21325134
22792074
19419957
21052091
18971343
25122754
11301010
21240188
|
BLM
|
POT1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
ACSN
|
16697054
18931676
19622404
19686080
19772495
19847258
22266823
22657828
23253856
24089143
24095737
|
BLM
|
TINF2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
ACSN
|
16697054
18931676
19622404
19686080
19772495
19847258
22266823
22657828
23253856
24089143
24095737
|
BLM
|
TERF2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
ACSN
|
16697054
18931676
19622404
19686080
19772495
19847258
22266823
22657828
23253856
24089143
24095737
|
BLM
|
FEN1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
12.0
|
1.0
|
ACSN
|
16697054
18931676
19622404
19686080
19772495
19847258
22266823
22657828
22973052
23253856
24089143
24095737
|
BLM
|
RAD50
|
â—¼ UP_REGULATES
|
✅
|
+
|
35.0
|
1.0
|
ACSN
|
12239151
12466554
12535671
12972610
14657033
14988723
15136767
15189446
16337602
16697054
17035102
18157158
18448394
18469862
18472307
18550849
18931676
19217833
19225445
19258535
19282663
19622404
19686080
19772495
19847258
20832754
21948210
22266823
22615860
22657828
23253856
23444773
24089143
24095737
8020957
|
TERF2
|
BLM
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
17145710
15229185
19329795
12181313
|
CHEK1
|
BLM
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
21050475
20719863
25015292
25906194
15364958
|
TERF1
|
BLM
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
17145710
15229185
|
BLM
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
12080066
11399766
22653443
24239288
15806145
11781842
16713569
15364958
|
BLM
|
FEN1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
22.0
|
1.0
|
Omnipath
|
17145710
19772495
18931676
19847258
22266823
12356323
19622404
16326861
24089143
22973052
23253856
22657828
16697054
24095737
19686080
14688284
|
NBN
|
BRCA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
22021381
16153896
18923075
18805091
21325134
22792074
19419957
21052091
18971343
25122754
11301010
21240188
|
BRCA1
|
RAD50
|
â—¼ PHYSICAL_INTERACTION
|
|
|
56.0
|
1.0
|
ACSN
|
11850621
11877377
12607003
14726013
15459660
15485915
15496928
15549137
15655342
15703371
16697054
17088286
17116881
17965729
18001825
18087292
18171670
18171986
18212739
18584027
18716619
18809224
19202191
19208614
19217833
19270065
19357644
19364882
19490890
196269035
19772495
19793801
19847258
20021983
20029420
20051983
20064462
20603072
20723763
21060331
21270334
21337561
21376743
22055391
22469522
22713970
22743550
22921416
23145148
23562323
23568489
24050180
24210699
24684389
24976506
9721205
|
BRCA1
|
BARD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
36.0
|
1.0
|
ACSN
|
10858305
10931916
11571269
11877377
12947387
15220350
15459660
15590677
15650050
16697054
17349954
18660752
18931676
19342239
19473888
19525936
19622404
19686080
19759212
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20081207
20376879
20723763
20813759
21060331
21337561
22505525
22751496
22771115
23444773
|
BRCA1
|
BRCA2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
69.0
|
1.0
|
ACSN
|
10858305
10931916
11571269
11756412
11850621
11877377
11927554
12239151
12551922
12607003
12947387
14624239
14726013
15220350
15459660
15590677
15650050
15703371
16337601
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18448394
18472307
18584027
18660752
18809224
18931676
19075014
19217432
19264559
19473888
19525936
19622404
19686080
1974050
19759212
19772495
19793801
19793861
19793862
19841479
19847258
19995904
20029420
20081207
20173781
20376879
20723763
20813759
21060331
21337561
21376743
21574959
22021614
22101340
22505525
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
BRCA1
|
E2F1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
24.0
|
1.0
|
ACSN
|
10884389
11877377
12496474
15175241
15220350
15279786
15459660
16581787
17218262
17303408
17660363
17713585
18458534
18590585
18660752
19525936
19793801
20029420
20376879
21060331
21337561
24254977
7575488
7935440
|
BRCA1
|
BRCC3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
10.0
|
1.0
|
ACSN
|
11877377
15459660
16697054
19342239
19772495
19793801
19847258
20029420
21060331
21337561
|
BRCA1
|
MRE11
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
22021381
16153896
18923075
18805091
21325134
22792074
19419957
21052091
18971343
25122754
11301010
21240188
|
BRCA1
|
E2F1
|
â—¼ SHARES_COMPLEX
|
|
|
24.0
|
1.0
|
ACSN
|
10884389
11877377
12496474
15175241
15220350
15279786
15459660
16581787
17218262
17303408
17660363
17713585
18458534
18590585
18660752
19525936
19793801
20029420
20376879
21060331
21337561
24254977
7575488
7935440
|
BRCA1
|
BRCC3
|
â—¼ SHARES_COMPLEX
|
|
|
10.0
|
1.0
|
ACSN
|
11877377
15459660
16697054
19342239
19772495
19793801
19847258
20029420
21060331
21337561
|
BRCA1
|
BARD1
|
â—¼ SHARES_COMPLEX
|
|
|
36.0
|
1.0
|
ACSN
|
10858305
10931916
11571269
11877377
12947387
15220350
15459660
15590677
15650050
16697054
17349954
18660752
18931676
19342239
19473888
19525936
19622404
19686080
19759212
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20081207
20376879
20723763
20813759
21060331
21337561
22505525
22751496
22771115
23444773
|
BRCA1
|
BRCA2
|
â—¼ SHARES_COMPLEX
|
|
|
69.0
|
1.0
|
ACSN
|
10858305
10931916
11571269
11756412
11850621
11877377
11927554
12239151
12551922
12607003
12947387
14624239
14726013
15220350
15459660
15590677
15650050
15703371
16337601
16337602
16697054
17303408
17349954
18082604
18082605
18085520
18087292
18448394
18472307
18584027
18660752
18809224
18931676
19075014
19217432
19264559
19473888
19525936
19622404
19686080
1974050
19759212
19772495
19793801
19793861
19793862
19841479
19847258
19995904
20029420
20081207
20173781
20376879
20723763
20813759
21060331
21337561
21376743
21574959
22021614
22101340
22505525
22743550
22751496
22771115
23414611
23444773
24050180
9488723
|
BRCA1
|
RAD50
|
â—¼ SHARES_COMPLEX
|
|
|
56.0
|
1.0
|
ACSN
|
11850621
11877377
12607003
14726013
15459660
15485915
15496928
15549137
15655342
15703371
16697054
17088286
17116881
17965729
18001825
18087292
18171670
18171986
18212739
18584027
18716619
18809224
19202191
19208614
19217833
19270065
19357644
19364882
19490890
196269035
19772495
19793801
19847258
20021983
20029420
20051983
20064462
20603072
20723763
21060331
21270334
21337561
21376743
22055391
22469522
22713970
22743550
22921416
23145148
23562323
23568489
24050180
24210699
24684389
24976506
9721205
|
TP53BP1
|
BRCA1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
7.0
|
1.0
|
ACSN
|
11042216
11877378
17243194
18087291
19342239
20646866
9748285
|
CHEK2
|
BRCA1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
16.0
|
1.0
|
ACSN
|
11438669
15459660
15810020
15867354
17296736
17464182
17568790
18048416
18566216
18756267
18931676
18971944
19686080
19788416
20019063
20126263
|
BRCA1
|
E2F1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
24.0
|
1.0
|
ACSN
|
10884389
11877377
12496474
15175241
15220350
15279786
15459660
16581787
17218262
17303408
17660363
17713585
18458534
18590585
18660752
19525936
19793801
20029420
20376879
21060331
21337561
24254977
7575488
7935440
|
MDC1
|
BRCA1
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
13.0
|
1.0
|
ACSN
|
12607003
15279786
15459660
17303408
17660363
18001824
18006705
18087291
18583988
18590585
18678890
7575488
9407949
|
BRCA1
|
CHEK1
|
â—¼ REGULATES
|
✅
|
|
22.0
|
1.0
|
ACSN
|
10367887
10779360
10962562
11877377
12024039
12170778
12496474
12771027
15242590
15459660
15485915
16818604
19004803
19357644
19686080
19788416
19793801
20029420
21060331
21337561
9346961
9892649
|
E2F4
|
BRCA1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
9.0
|
1.0
|
Omnipath
|
20133863
21701264
17531812
17001309
20818429
17106239
23108140
|
E2F1
|
BRCA1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
10660629
23285190
18660752
19466541
17106239
20068145
23108140
|
MYC
|
BRCA1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
12032322
19882681
20940401
10375022
21668996
11916966
12646176
11983916
|
TP53
|
BRCA1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
24.0
|
1.0
|
Omnipath
|
9582019
11295099
18625847
11003642
12802282
16357511
14710355
9619832
19882681
10884389
11384963
11782367
12024039
15735697
12170778
21245169
17993233
12549011
11431698
16229810
18208621
10597265
21742769
|
BRCA1
|
SIRT1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
20160719
18851829
9000507
21407215
|
BRCA1
|
CDKN1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
9926942
11394910
10196224
18025037
21245169
16735508
12647291
|
E2F4
|
BRCA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
9244350
18319725
16713569
12909625
|
BARD1
|
BRCA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
99.0
|
1.0
|
Omnipath
|
16403807
16391231
28262780
15159397
25652403
26350354
26490435
14647430
11927591
25184681
16713569
11526114
35203293
9738006
12732733
24289923
11573085
18936166
23086937
24085845
12890688
15855157
24695549
19369211
9798686
11257228
11498787
12700228
11925436
10477523
19176389
23680151
25634209
23416467
34726323
29355525
18369654
14636569
11504724
12951069
19117993
20060929
17873885
14638690
18493658
11278247
15184379
22110403
11301010
11773071
12431996
10635334
20029420
9788437
17664283
21901007
25252691
12485996
10026184
12438698
17525341
16489000
8944023
15265711
12419249
20681793
9342365
27239795
20215511
25823446
19916563
|
E2F1
|
BRCA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
9244350
18660752
18319725
11278247
12697828
16713569
12909625
|
CDK2
|
BRCA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
8764100
10373534
10550055
19683496
16713569
26719576
15212693
|
CHEK2
|
BRCA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
43.0
|
1.0
|
Omnipath
|
18566216
15810020
24492479
20860841
16713569
26383678
10724175
12049740
24986639
23388117
14701743
30327455
33397362
22921572
18804494
24348208
20364141
22941656
15459660
17464182
20952512
24069304
15485917
22193408
12111733
27170701
|
MDC1
|
BRCA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
18087291
17525332
12607005
|
BRIP1
|
BRCA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
42.0
|
1.0
|
Omnipath
|
22032289
21240188
34591612
18285836
16713569
14576432
17596542
17525342
17525340
15242590
25184681
19369211
18369654
28911102
17581638
15125843
11301010
15133502
19452558
27399284
18717574
17525341
22792074
14576433
20173781
11877378
20681793
14578343
|
RAD50
|
BRCA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
10783165
16260778
16391231
10426999
11504724
25084169
25184681
16713569
|
BRCA1
|
RBBP8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
40.0
|
1.0
|
Omnipath
|
21908405
18285836
16713569
15485915
25310973
9738006
17525342
17525340
16843262
24085845
25184681
26387952
18369654
9811458
16818604
20351172
23416467
19442256
10196224
10910365
19452558
11739404
25252691
10764811
25659039
17965729
11689934
|
BRCA1
|
PALB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
26649820
19268590
28089683
28319063
19369211
|
BRCA2
|
BARD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
35.0
|
1.0
|
ACSN
|
10858305
10931916
11571269
11877377
12947387
15220350
15459660
15590677
15650050
16697054
17349954
18660752
18931676
19473888
19525936
19622404
19686080
19759212
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20081207
20376879
20723763
20813759
21060331
21337561
22505525
22751496
22771115
23444773
|
BRCA2
|
BARD1
|
â—¼ SHARES_COMPLEX
|
|
|
35.0
|
1.0
|
ACSN
|
10858305
10931916
11571269
11877377
12947387
15220350
15459660
15590677
15650050
16697054
17349954
18660752
18931676
19473888
19525936
19622404
19686080
19759212
19772495
19793801
19793861
19793862
19841479
19847258
20029420
20081207
20376879
20723763
20813759
21060331
21337561
22505525
22751496
22771115
23444773
|
TP53
|
BRCA2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
9619832
11295099
18765668
12591928
|
PALB2
|
BRCA2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
32.0
|
1.0
|
Omnipath
|
17420451
16793542
26990772
19268590
22293751
17488615
19369211
23585894
24485656
20332121
24141787
26649820
19553677
17200672
26833090
23038782
17200668
15115758
19609323
30410870
19584259
22193777
|
BARD1
|
BRCC3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
10.0
|
1.0
|
ACSN
|
11877377
15459660
16697054
19342239
19772495
19793801
19847258
20029420
21060331
21337561
|
BARD1
|
BRCC3
|
â—¼ SHARES_COMPLEX
|
|
|
10.0
|
1.0
|
ACSN
|
11877377
15459660
16697054
19342239
19772495
19793801
19847258
20029420
21060331
21337561
|
BRCC3
|
TP53BP1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
7.0
|
1.0
|
ACSN
|
11042216
11877378
17243194
18087291
19342239
20646866
9748285
|
NBN
|
BRIP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
22021381
16153896
18923075
18805091
21325134
22792074
19419957
21052091
18971343
25122754
11301010
21240188
|
RBBP8
|
BRIP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
22021381
16153896
18923075
18805091
21325134
22792074
19419957
21052091
18971343
25122754
11301010
21240188
|
RAD50
|
BRIP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
22021381
16153896
18923075
18805091
21325134
22792074
19419957
21052091
18971343
25122754
11301010
21240188
|
KAT5
|
BRIP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
22021381
16153896
18923075
18805091
21325134
22792074
19419957
21052091
18971343
25122754
11301010
21240188
|
MRE11
|
BRIP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
22021381
16153896
18923075
18805091
21325134
22792074
19419957
21052091
18971343
25122754
11301010
21240188
|
TOPBP1
|
BRIP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
20159562
25374583
|
MAPK3
|
CAPN2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
11319218
26248159
14993287
10644690
|
MAPK1
|
CAPN2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
11319218
14993287
10644690
|
MYC
|
CCND1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
7526316
21933022
17881732
12835716
14757441
19086036
8552398
19698176
19786833
18809243
18806825
8196642
11085504
|
PPARG
|
CCND1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
9.0
|
1.0
|
Omnipath
|
23455892
18927468
14764597
15486348
11287611
20651819
15041706
19075513
15193259
|
TP53
|
CCND1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
17.0
|
1.0
|
Omnipath
|
24189068
8702807
10669755
22270849
12808109
17942917
19086036
20731879
16061648
20554748
24460719
11798189
10082575
15205322
18769160
19800042
|
E2F1
|
CCND1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
10504464
7929342
22768064
19876926
20220142
9584162
17998543
20655656
8618861
8137237
23078099
23543735
10594784
|
STAT3
|
CCND1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
30.0
|
1.0
|
Omnipath
|
16510571
19880237
17997399
15469392
16651438
21163886
22566696
16912181
22349830
16384639
12147685
21344490
20160059
19506034
20332458
23329648
11114718
17761947
22218594
15994929
21172343
18988190
18177723
24499623
21435102
19926637
18184402
17344214
22313388
23950841
|
FOXM1
|
CCND1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
16585184
11572993
10567581
11391529
|
EP300
|
CCND1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
17306568
17666529
11788592
23343194
21285352
15576399
21151179
22761862
22290435
16039586
19619488
19623618
17143292
|
CDKN1A
|
CCND1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
31.0
|
1.0
|
Omnipath
|
26203195
23443559
17145710
25416956
7478582
9837900
21988832
21516116
7777546
15232106
16082198
27107012
15695403
8657154
8242751
23007395
9106657
12383116
17556661
8756624
8662825
31515488
|
CDC25A
|
CCND1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
7575488
18590585
17303408
18073536
1075565
17568790
18786381
17660363
15279786
|
MYC
|
CCND1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
8425218
15121849
2006410
17873522
21406394
12584560
17558397
20551172
15814658
16908182
|
CCND1
|
CDK6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
17.0
|
1.0
|
Omnipath
|
19075005
17517622
9178893
11739795
24855949
15232106
16713569
11360184
10580009
11160398
|
CCND1
|
E2F1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
18.0
|
1.0
|
Omnipath
|
9190208
10498883
18590585
7575488
9315635
17303408
10385618
10778858
9736735
16236519
20068082
7736585
9425340
11520855
19075565
18786381
17660363
15279786
|
CCND1
|
RBL2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
16600870
10498883
10385618
9736735
12006580
|
CHEK2
|
CDC25A
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
16.0
|
1.0
|
ACSN
|
11438669
15459660
15810020
15867354
17296736
17464182
17568790
18048416
18566216
18756267
18931676
18971944
19686080
19788416
20019063
20126263
|
SKP2
|
CDC25A
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
17.0
|
1.0
|
ACSN
|
11900249
12648680
12820959
15071497
15147722
15340381
15459660
15688063
15703371
16697054
17884153
18931676
19270156
19622404
19686080
19809470
19847258
|
CHEK1
|
CDC25A
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
ACSN
|
15459660
15798197
17102137
17116885
17296725
17384638
17568790
17582221
18677104
19793801
20126263
|
CDC25A
|
CDK2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
9.0
|
1.0
|
ACSN
|
1075565
15279786
17303408
17568790
17660363
18073536
18590585
18786381
7575488
|
E2F1
|
CDC25A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
11154267
11799067
19633359
|
MYC
|
CDC25A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
8994810
10205150
11154267
9371770
14519204
15677471
17671423
|
CHEK2
|
CDC25A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
52.0
|
1.0
|
Omnipath
|
18566216
12676583
15810020
18285803
12759351
14681206
20860841
16682204
9836640
10724175
29725502
23855452
20126263
18480045
11298456
20587702
15459660
20514219
22263797
27038604
17464182
14559997
12399544
17568790
24882577
19101576
|
BTRC
|
CDC25A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
19847258
14603323
15340381
19686080
19270156
17884153
19622404
15703371
12648680
11900249
16697054
18931676
19809470
15459660
|
CHEK1
|
CDC25A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
75.0
|
1.0
|
Omnipath
|
12676583
22040655
29435105
12759351
14681206
18677104
20860841
15798197
19793801
22655267
12963847
16682204
14752276
16647857
15736430
29725502
17116885
17582221
20126263
16697662
18167338
19075565
9278511
18480045
17384638
21148633
21252624
27493659
12110582
17030123
23335075
20068082
11298456
27908669
27213455
25936524
15459660
28150240
20798862
22263797
27038604
17296725
14559997
12399544
17102137
17568790
16488126
|
FOXM1
|
CDC25A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
15689977
11572993
11391529
16314512
|
MYC
|
CDC25A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
8425218
15121849
11602341
2006410
17873522
21406394
12584560
17558397
20551172
15814658
16908182
|
CDC25A
|
CDK6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
7575488
18590585
17303408
18073536
1075565
17568790
23429262
18786381
17660363
15279786
|
CDC25A
|
CCNA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
7575488
18590585
17303408
18073536
10926775
1075565
17568790
16189514
18786381
17660363
15279786
|
CDC25A
|
CDK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
26.0
|
1.0
|
Omnipath
|
8617791
11602341
17303408
18073536
1075565
15279786
7575488
10454565
11154267
12411508
16189514
1396589
18590585
18786381
17660363
12388094
22263797
27485204
17568790
15659558
|
CCNA2
|
CDK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
999.0
|
1.0
|
STRING
|
36370105
|
MYC
|
CDK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
34.0
|
1.0
|
ACSN
|
11274345
11283614
12545156
14536078
15147722
15155580
15279786
17055429
17303408
17550342
17558397
17660363
17873522
18590585
18636226
19887899
20027199
20237412
20551172
20581311
20713526
20818389
21406394
21733352
2191300
21919891
22067385
23140366
23869868
24954210
25002027
28536364
7575488
9618481
|
CDK2
|
MLH1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
9781043
16322221
16123081
11292842
10928988
|
CCNA1
|
CDK2
|
â—¼ PROTEIN_INTERACTION
|
|
|
1.0
|
1.0
|
HIPPIE
|
16189514
15583032
25241761
16777603
10559988
14681455
9636170
16159883
9041194
10652300
8565853
12970441
14701826
8397206
14681231
11264176
8397207
15601848
12191604
12190313
7799941
19423708
12800980
16009130
|
MYC
|
CDK2
|
â—¼ SHARES_COMPLEX
|
|
|
34.0
|
1.0
|
ACSN
|
11274345
11283614
12545156
14536078
15147722
15155580
15279786
17055429
17303408
17550342
17558397
17660363
17873522
18590585
18636226
19887899
20027199
20237412
20551172
20581311
20713526
20818389
21406394
21733352
2191300
21919891
22067385
23140366
23869868
24954210
25002027
28536364
7575488
9618481
|
CDK2
|
E2F1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
27.0
|
1.0
|
ACSN
|
12086603
14536078
14988723
15136767
15147722
15175241
15279786
15798197
16713580
16805667
17102137
17116885
17296725
17303408
17384638
17582221
17660363
18469862
18590585
18636226
18995830
19282663
19342888
19622404
19793801
20051983
7575488
|
CDK2
|
MCM5
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
18.0
|
1.0
|
ACSN
|
14536078
15147722
15175241
15279786
15677884
16581787
17038621
17102137
17116885
17296725
17303408
17582221
17660363
17713585
18590585
18636226
19793801
7575488
|
CDK2
|
CDKN2A
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
32.0
|
1.0
|
ACSN
|
11274345
11283614
12545156
14536078
15147722
15155580
15279786
17055429
17303408
17550342
17558397
17660363
17873522
18590585
18636226
20027199
20237412
20551172
20581311
20713526
20818389
21406394
21733352
2191300
21919891
22067385
23140366
23869868
25002027
28536364
7575488
9618481
|
E2F4
|
CDK2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
17531812
22447046
|
MAPK1
|
CDK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
10962581
12359725
|
CDK2
|
RBBP8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
23623683
33097710
27308383
24236237
19202191
24982848
25956864
22743550
|
CDK2
|
LIG3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
17040896
|
CDK2
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
8386367
27653698
17081983
19966300
18669648
29896817
17570479
20713526
17558397
15103331
22348395
20445224
|
CDK2
|
NPM1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
67.0
|
1.0
|
Omnipath
|
32076484
26123729
17081983
27998958
16565220
19007248
19367720
23840880
12058066
19690332
22285574
25922180
21272329
19413330
20333249
24282781
32092641
27553022
19933848
19933706
16083285
18318008
20068231
24998852
23627734
26993766
18165222
17535915
18669648
24290756
17942908
81161106
18691976
11278991
19561638
17287340
16376875
18243139
19651622
17924679
18220336
24282525
19369195
15190079
25531824
18212344
|
CDK2
|
RBL2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
17.0
|
1.0
|
Omnipath
|
20857408
17570479
11042701
9188854
11157749
12006580
15212693
10825149
|
CDK2
|
SKP2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
27.0
|
1.0
|
Omnipath
|
7553852
20160477
23602568
25271736
18239684
28446188
23226679
10386600
19270695
26496610
16189514
25852190
26186194
25788262
9858587
22770219
15355997
10559858
23807222
22311674
16979657
9636170
19686743
19270694
18604603
23455922
|
CDK2
|
FOXM1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
28387346
15024056
19737929
|
CDK2
|
E2F1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
11.0
|
1.0
|
Omnipath
|
7575488
18590585
9315635
17303408
17570479
25101673
16213134
17660363
12006580
11420722
15279786
|
CDK2
|
CDKN1A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
94.0
|
1.0
|
Omnipath
|
23443559
23455922
10878006
20100570
23602568
15964852
20839231
25416956
23737759
9840943
18850315
11302688
20519948
24358021
19440234
15557281
9472014
9658399
16962592
9736735
12949733
8641969
10022118
15890360
12839982
16765349
17418410
15647383
10874474
15232106
17570479
17698606
12361598
26496610
9632134
24419005
12417722
16189514
26186194
20587660
25241761
8622677
9660939
25483090
12800980
20102411
10918595
12058028
12144826
8242751
9464540
9858587
29899857
23007395
11477082
9218599
12383116
25463440
12730199
8756624
9284049
9380407
9546435
24218572
16964243
15212693
13678583
|
CDK2
|
CCNA2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
81.0
|
1.0
|
Omnipath
|
8756328
7553852
11377199
17145710
23602568
11983168
12044161
19483727
12853968
16209941
8397207
15455144
19631451
8475101
24358021
15557281
8684460
12941338
15647383
15890360
21447625
9380407
26496610
11141566
25852190
15189033
14656438
20733051
21241890
10652300
25669885
12244298
26186194
10930425
9660939
10477583
24302728
15239650
19773423
8463339
16290148
10924145
11907280
17361108
17254966
8662825
15828833
18471975
9724724
7630397
10559988
9716181
11940657
23455922
|
CDK2
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
39.0
|
1.0
|
Omnipath
|
24173284
9315650
19413330
19664995
16083285
1088347
16552184
10884347
17570479
10747897
25241761
7624134
11687964
17287340
92065884
12064478
19556892
14640983
10348343
14702041
|
CDK2
|
CHEK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
21765472
21965652
21907702
18983824
24242917
|
CDKN1A
|
CDK6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
14517297
17092340
9106657
18710949
24515438
20843055
|
E2F3
|
CDKN1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
17008321
10030670
22894933
17167174
15855772
|
TP53
|
CDKN1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
389.0
|
1.0
|
Omnipath
|
9349504
22270849
8749722
21242964
22290440
23874636
23349794
23650552
17280505
16288208
19882681
22948151
8641969
18840648
7777546
9360984
9707425
14614448
15586362
12889596
10597242
18719376
17938176
16343438
9916993
12806965
15024021
10037739
19394332
19749793
22480684
15136035
19501055
22732402
15988033
17307334
18272192
23665236
20331637
10435630
12239594
14743206
24599959
9714336
9652736
19954840
12392301
15339933
9154806
19383287
21295542
16894028
23187802
15248906
14522900
18483411
16261158
11892838
20190809
17167174
18615633
15790310
17916908
19472317
12717415
19789303
16317118
7696178
24584189
22989750
18573881
22532570
9288775
16103882
11890931
17646389
17344317
10753197
8557703
15872011
24356969
11278953
22279545
12902982
9920903
18644983
21524151
16540664
10935506
16537920
19843844
9535786
17878219
9405685
10749849
18656471
11021966
19723072
16778363
18628250
16557594
9614553
21791610
10072388
12203124
12420214
12640112
16601686
20531308
15741235
17317670
18446786
18505818
9224526
17569660
21900401
14517211
12934105
22713239
11313928
15492238
17509529
15985438
14722112
18755897
15489892
23759594
7624148
17786325
9223430
24074410
9525742
11395510
21317932
11444825
18645021
15856024
10559267
18593586
16970927
12665570
10101800
23017582
20696891
9268733
22001409
24821728
23146670
22427654
12573582
19118657
11973611
24096481
20797428
17685229
23066038
10029406
12681065
12433990
18769160
15208672
11152513
8547219
15851483
23474493
24384472
11175333
17158927
23100276
17762884
18951877
12045203
15051477
16107883
18521083
23159636
8603071
20814747
15082782
11375890
21084835
10348346
22244155
21325288
12379483
14580351
17592775
8910340
15566940
12173040
12007564
12609999
8878553
12080472
12384701
22266868
17404570
23329847
7478511
15067082
15007388
16458891
9268365
15728246
17224908
10094833
15897882
18059034
11739748
7624134
17146435
18690848
21528307
21546904
18208621
18172861
17977830
17721438
20817677
22894933
18225552
21642427
11162600
9183012
8647846
10660101
21858218
22514644
18451802
11384995
20673369
7774811
20187950
16230382
17339230
12168779
19630958
8242752
9895308
21606339
11748232
16410722
22611192
16061648
15009091
22503977
8799837
15660129
20473858
20448457
16488074
14612423
21903579
11668476
11313463
17101782
19067706
17121856
10792001
16341121
12925527
7566157
22190353
12782287
9233781
15509808
21245169
17145718
24134839
10498892
18094076
14635196
23208500
20843368
10327058
21969549
9440695
10625687
20885946
12851404
19846554
10910098
14614455
18419600
21552844
24835508
21541551
9472102
11922774
19244234
17903248
9216067
18193090
10566557
18757425
11429705
19608464
8632901
8691637
15184659
12716906
15259070
24559687
7970699
15738655
9588214
16574813
15302882
12560513
16131836
16778203
10522058
11032828
9816111
9108440
15860260
17108107
25024194
9582019
22266186
20036872
9926942
15710329
19243472
17997002
19435914
21093383
23149933
11162506
17678435
11895854
8616838
12748190
17610896
18269916
22086179
21557991
17942917
24821727
11557753
16204065
18645003
24205274
9816061
12226108
24379401
15539944
7753560
15371422
10799578
10777217
16434701
17996705
21957244
9191059
9519881
9207798
24289924
21733196
15496412
20124454
20153576
22172947
10321740
21715977
22253232
8816885
24189165
15882981
8752276
20511722
11514734
20962589
12869419
16733561
19713748
16931520
10499591
16581545
19738071
|
FOXO3
|
CDKN1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
18312651
18005957
16908841
20671123
21249150
|
MYC
|
CDKN1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
41.0
|
1.0
|
Omnipath
|
15190211
14519204
15616584
12408868
19174556
21949397
10319992
12553001
16204065
12545156
20878079
21042278
21400515
20190815
16706751
23804320
15757889
10920185
19270520
16452181
12408820
15528212
22371483
12565816
17885207
12384701
11274368
19150257
20551174
15899785
21120446
15071503
15474507
22814619
12835716
12748190
16738884
15711923
18636159
|
E2F1
|
CDKN1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
9748148
9191053
16923815
17008321
10030670
10702805
15048076
17167174
|
STAT3
|
CDKN1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
23178160
19372587
15286705
18320073
15063116
16923815
9694869
22328012
12438313
11773079
20654581
10023678
19329556
21184768
11114718
|
FOXM1
|
CDKN1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
16314512
20887555
23804320
17101782
19097132
|
EP300
|
CDKN1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
10362258
15509808
21858218
22000024
21245169
|
PPARG
|
CDKN1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
19551868
19103521
19208833
16985067
18509005
15041706
15345676
16091736
|
TP53
|
CDKN1A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
24.0
|
1.0
|
Omnipath
|
19922265
12897156
19597488
16616141
28433629
20066118
20457558
19749794
6396087
21163364
17371838
21900206
21340684
25241761
12897801
12748190
20182602
11896572
|
SKP2
|
CDKN1A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
15.0
|
1.0
|
Omnipath
|
32035614
25241761
23261596
17679094
15998794
17477906
19686743
16376880
15980415
18794347
13678583
|
AKT3
|
CDKN1A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
14.0
|
1.0
|
Omnipath
|
12851486
15023346
19216069
17680028
11756412
16680151
20214616
11463845
23109003
20452955
9829964
20398329
17646672
10217147
|
MDM2
|
CDKN1A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
17373842
25241761
20086099
14633995
14761977
20308078
|
AKT2
|
CDKN1A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
17.0
|
1.0
|
Omnipath
|
19216069
17680028
11756412
16680151
20214616
11463845
21933447
16982699
20452955
9829964
20398329
17646672
10217147
|
MAPK1
|
CDKN1A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
20519948
19364816
28368408
|
MYC
|
CDKN1A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
11.0
|
1.0
|
Omnipath
|
15528212
9618481
12545156
17550342
10454538
15155580
11283613
10920185
11283614
|
FOXO3
|
CDKN1A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
15084259
19380174
21708191
15084260
21613825
17940099
11154281
|
CDK6
|
CDKN1A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
12.0
|
1.0
|
Omnipath
|
25121590
20102411
15964852
22375140
15232106
16713569
16508017
19440234
|
MAPK14
|
CDKN1A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
23745637
12058028
|
MAPK8
|
CDKN1A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
19.0
|
1.0
|
Omnipath
|
12730199
15964852
17325029
19664994
12058028
11779850
17570479
20519948
16964243
18669648
|
CDKN1A
|
CCND2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
17.0
|
1.0
|
Omnipath
|
23443559
26186194
25241761
27107012
8756624
15169570
25416956
16765349
31515488
16189514
32296183
|
CDKN1A
|
CCNA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
15.0
|
1.0
|
Omnipath
|
12383116
25241761
8756624
29997244
16982699
7478582
10022926
32814053
15232106
16009130
16189514
|
CDKN1A
|
CCNA2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
16.0
|
1.0
|
Omnipath
|
23443559
26186194
21308745
9660939
8756624
15890360
9380407
8242751
8662825
12947099
9632134
17679094
26496610
|
CDKN1A
|
STAT3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
25241761
16189514
10764767
|
CDKN1A
|
E2F1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
18.0
|
1.0
|
Omnipath
|
9190208
10498883
18590585
7575488
9315635
17303408
10385618
10778858
9736735
16236519
20068082
7736585
9425340
11520855
19075565
18786381
17660363
15279786
|
EP300
|
CDKN2A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
32284348
19273602
32601262
10821856
28985506
33043019
31597407
|
MYC
|
CDKN2A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
19.0
|
1.0
|
ACSN
|
11274345
11283613
11283614
11704864
15199070
17055429
17558397
17873522
20027199
20237412
20551172
20581311
20713526
21406394
2191300
22067385
25002027
28536364
9694806
|
MYC
|
CDKN2A
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
19.0
|
1.0
|
ACSN
|
11274345
11283613
11283614
11704864
15199070
17055429
17558397
17873522
20027199
20237412
20551172
20581311
20713526
21406394
2191300
22067385
25002027
28536364
9694806
|
HRAS
|
CDKN2A
|
â—¼ UP_REGULATES
|
✅
|
+
|
15.0
|
1.0
|
ACSN
|
10358164
12134164
12447393
14764585
16102570
17673906
20841469
24027568
24954210
7510700
7673236
8551221
9069260
9763606
9846483
|
TP53
|
CDKN2A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
40.0
|
1.0
|
Omnipath
|
16103197
22467867
18555006
8631601
11402335
19649205
22020338
21164364
17265068
16764954
15775976
22056554
18275833
21483786
10348346
19216023
12384561
12091906
19901969
11360201
15205322
11818069
21892281
10980602
11739748
11559812
24672805
10097151
17907153
19244234
15361884
10652576
9436028
21447739
20569441
21555589
21637567
10816133
9774662
19240179
|
MYC
|
CDKN2A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
20.0
|
1.0
|
Omnipath
|
15361884
11593429
11507042
20023701
23342141
16537449
23277542
10914736
9212167
12835716
24177224
11062467
15199070
18762810
19786833
20551174
11360201
23722468
|
E2F3
|
CDKN2A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
18663357
15175242
11883935
19340300
|
ETS1
|
CDKN2A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
17370299
22714536
11234019
19240179
|
E2F1
|
CDKN2A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
19.0
|
1.0
|
Omnipath
|
11314038
12766778
20664976
10914734
16211008
10594030
11062467
11705881
11526499
15716352
19641316
21765927
22621932
19115249
11870517
12695664
20580656
15175242
17912037
|
E2F2
|
CDKN2A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
18319725
11883935
|
NPM1
|
CDKN2A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
16957780
20208519
15289458
16199867
16915296
|
E2F3
|
CDKN2A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
15177020
15175242
18319725
11883935
|
E2F1
|
CDKN2A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
11314038
16135794
11883935
12446760
18319725
15175242
11034215
|
MYC
|
CDKN2A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
17.0
|
1.0
|
Omnipath
|
15361884
9308237
10373560
17936558
12209154
12738781
17873522
11283613
21406394
9312026
15095404
17558397
20551172
19901969
19815509
10504341
|
CDKN2A
|
MDM2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
57.0
|
1.0
|
Omnipath
|
12167711
18541670
23416275
9529249
17426254
12630860
17116689
12085228
15856024
10822382
19166854
12209154
12740913
17158541
16915296
17909018
25809483
9653180
14612427
22120712
16173922
10871849
18418067
24769896
9724636
21133853
10801444
19049976
9529248
16107876
18813780
20713054
18467333
15355988
18583933
20395212
11223036
|
CDKN2A
|
CDK6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
18.0
|
1.0
|
Omnipath
|
17881001
26186194
23602568
9751050
11739795
11556834
9380698
15232106
16713569
17955473
10491434
16915296
17909018
|
CDKN2A
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
8.0
|
1.0
|
Omnipath
|
15856024
15989956
9724636
19960022
12740913
17158541
12640129
19590512
|
RAD1
|
CHEK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
38.0
|
1.0
|
ACSN
|
10884395
11877377
12086603
12766152
14726013
14988723
15136767
15175241
15459660
15485915
15703371
15798197
16530042
16697054
16713580
16805667
16880517
16885023
16934469
17102137
17116885
17296725
17303408
17384638
17493829
17582221
18469862
18677104
18995830
19282663
19342888
19622404
19793801
19847258
20051983
20478261
8943031
9524127
|
TOPBP1
|
CHEK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
52.0
|
1.0
|
ACSN
|
11756412
11877377
12086603
12466554
12766152
12875843
14624239
14657033
14726013
14988723
15136767
15175241
15189446
15459660
15485915
15703371
15798197
16530042
16697054
16713580
16805667
16880517
16885023
16934469
17035102
17102137
17116885
17141802
17296725
17303408
17384638
17582221
18157158
18451105
18469862
18677104
18931676
18995830
19158510
19217833
19225445
19258535
19282663
19342888
19622404
19686080
1974050
19793801
19847258
20051983
22021614
23414611
|
CHEK1
|
MCM5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
43.0
|
1.0
|
ACSN
|
10884395
11877377
11900249
12086603
12648680
12766152
12875843
14624239
14726013
14988723
15136767
15175241
15459660
15703371
15798197
16697054
16713580
16805667
16880517
16885023
16934469
17102137
17116885
17141802
17296725
17303408
17384638
17493829
17582221
17884153
18469862
18677104
18995830
19282663
19342888
19622404
19793801
19809470
19847258
20051983
20478261
8943031
9524127
|
RAD1
|
CHEK1
|
â—¼ SHARES_COMPLEX
|
|
|
38.0
|
1.0
|
ACSN
|
10884395
11877377
12086603
12766152
14726013
14988723
15136767
15175241
15459660
15485915
15703371
15798197
16530042
16697054
16713580
16805667
16880517
16885023
16934469
17102137
17116885
17296725
17303408
17384638
17493829
17582221
18469862
18677104
18995830
19282663
19342888
19622404
19793801
19847258
20051983
20478261
8943031
9524127
|
TOPBP1
|
CHEK1
|
â—¼ SHARES_COMPLEX
|
|
|
52.0
|
1.0
|
ACSN
|
11756412
11877377
12086603
12466554
12766152
12875843
14624239
14657033
14726013
14988723
15136767
15175241
15189446
15459660
15485915
15703371
15798197
16530042
16697054
16713580
16805667
16880517
16885023
16934469
17035102
17102137
17116885
17141802
17296725
17303408
17384638
17582221
18157158
18451105
18469862
18677104
18931676
18995830
19158510
19217833
19225445
19258535
19282663
19342888
19622404
19686080
1974050
19793801
19847258
20051983
22021614
23414611
|
RAD1
|
CHEK1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
38.0
|
1.0
|
ACSN
|
10884395
11877377
12086603
12766152
14726013
14988723
15136767
15175241
15459660
15485915
15703371
15798197
16530042
16697054
16713580
16805667
16880517
16885023
16934469
17102137
17116885
17296725
17303408
17384638
17493829
17582221
18469862
18677104
18995830
19282663
19342888
19622404
19793801
19847258
20051983
20478261
8943031
9524127
|
TOPBP1
|
CHEK1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
52.0
|
1.0
|
ACSN
|
11756412
11877377
12086603
12466554
12766152
12875843
14624239
14657033
14726013
14988723
15136767
15175241
15189446
15459660
15485915
15703371
15798197
16530042
16697054
16713580
16805667
16880517
16885023
16934469
17035102
17102137
17116885
17141802
17296725
17303408
17384638
17582221
18157158
18451105
18469862
18677104
18931676
18995830
19158510
19217833
19225445
19258535
19282663
19342888
19622404
19686080
1974050
19793801
19847258
20051983
22021614
23414611
|
E2F1
|
CHEK1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
12.0
|
1.0
|
ACSN
|
10884389
12496474
15220350
15279786
17218262
17303408
17660363
18590585
18660752
19525936
20376879
7575488
|
CHEK1
|
MCM5
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
43.0
|
1.0
|
ACSN
|
10884395
11877377
11900249
12086603
12648680
12766152
12875843
14624239
14726013
14988723
15136767
15175241
15459660
15703371
15798197
16697054
16713580
16805667
16880517
16885023
16934469
17102137
17116885
17141802
17296725
17303408
17384638
17493829
17582221
17884153
18469862
18677104
18995830
19282663
19342888
19622404
19793801
19809470
19847258
20051983
20478261
8943031
9524127
|
RAD1
|
CHEK1
|
â—¼ UP_REGULATES
|
✅
|
|
38.0
|
1.0
|
ACSN
|
10884395
11877377
12086603
12766152
14726013
14988723
15136767
15175241
15459660
15485915
15703371
15798197
16530042
16697054
16713580
16805667
16880517
16885023
16934469
17102137
17116885
17296725
17303408
17384638
17493829
17582221
18469862
18677104
18995830
19282663
19342888
19622404
19793801
19847258
20051983
20478261
8943031
9524127
|
CHEK1
|
MCM5
|
â—¼ REGULATES
|
✅
|
|
43.0
|
1.0
|
ACSN
|
10884395
11877377
11900249
12086603
12648680
12766152
12875843
14624239
14726013
14988723
15136767
15175241
15459660
15703371
15798197
16697054
16713580
16805667
16880517
16885023
16934469
17102137
17116885
17141802
17296725
17303408
17384638
17493829
17582221
17884153
18469862
18677104
18995830
19282663
19342888
19622404
19793801
19809470
19847258
20051983
20478261
8943031
9524127
|
TP53
|
CHEK1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
9.0
|
1.0
|
Omnipath
|
21546904
11158294
20190799
19435816
18632613
15016801
19395378
11152453
18753293
|
E2F1
|
CHEK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
7575488
18590585
20376879
17303408
18660752
19525936
17660363
15220350
15279786
|
CHEK2
|
CHEK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
26516160
24804719
26437226
29555944
|
CHEK1
|
MDM4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
16.0
|
1.0
|
Omnipath
|
16163388
16511572
18356162
17110929
|
CHEK1
|
H3C2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
13.0
|
1.0
|
Omnipath
|
18451105
20068082
23844048
12560483
18066052
20948546
21357687
18243098
|
CHEK1
|
AURKB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
23321637
22024163
17276342
|
CHEK1
|
TLK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
12660173
20068082
12955071
|
CHEK1
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
64.0
|
1.0
|
Omnipath
|
20950777
18778462
25545885
18677104
20860841
15798197
19793801
22891162
16511572
23852422
16713569
15865930
11551930
19923893
15467443
11709713
21748595
17116885
15659650
17582221
26384650
10673501
17384638
23966620
23892398
17118344
9765199
15140942
19788416
10801407
18319725
12781359
12897801
25823026
15459660
23296650
15024084
17296725
17102137
11896572
17339337
19933256
20526329
28140789
|
MDC1
|
CHEK2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
59.0
|
1.0
|
ACSN
|
11331603
11850621
11877377
12086603
12556884
12607003
14614141
14988723
15136767
15140942
15175241
15242590
15279786
15375219
15377654
15459660
15485915
15798197
15964794
16163361
16332722
16531125
16713580
16805667
16818604
16858402
17102137
17116885
17296725
17303408
17384638
17582221
17660363
18006705
18087292
18469862
18543256
18583988
18584027
18590585
18678890
18809224
18995830
19151707
19282663
19342888
19622404
19686080
19772495
19793801
20051983
20723763
21376743
22743550
23847781
24050180
7575488
9407949
9488723
|
RAD50
|
CHEK2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
59.0
|
1.0
|
ACSN
|
11331603
11850621
11877377
12086603
12556884
12607003
14614141
14988723
15136767
15140942
15175241
15242590
15279786
15375219
15377654
15459660
15485915
15798197
15964794
16163361
16332722
16531125
16713580
16805667
16818604
16858402
17102137
17116885
17296725
17303408
17384638
17582221
17660363
18006705
18087292
18469862
18543256
18583988
18584027
18590585
18678890
18809224
18995830
19151707
19282663
19342888
19622404
19686080
19772495
19793801
20051983
20723763
21376743
22743550
23847781
24050180
7575488
9407949
9488723
|
CHEK2
|
XRCC1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
16.0
|
1.0
|
ACSN
|
11438669
15459660
15810020
15867354
17296736
17464182
17568790
18048416
18566216
18756267
18931676
18971944
19686080
19788416
20019063
20126263
|
CHEK2
|
TP53
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
10710310
10673501
10570149
10673500
|
TP53
|
CHEK2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
15326376
19435816
10531348
19395378
15044452
|
MDC1
|
CHEK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
31.0
|
1.0
|
Omnipath
|
12607004
18087292
17303408
20723763
18678890
19793801
9488723
12919958
24050180
15279786
7575488
16163361
18584027
18583988
22743550
16531125
23847781
18590585
15964794
21376743
12551934
12607003
17660363
15459660
19772495
11877377
18809224
11850621
9407949
18006705
|
NBN
|
CHEK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
34.0
|
1.0
|
Omnipath
|
18087292
17303408
20723763
18678890
19793801
9488723
11438675
24050180
15279786
7575488
16163361
18584027
18583988
22743550
16531125
23847781
18590585
15140942
15964794
21376743
12773400
10973490
12607003
17660363
15459660
15024084
19772495
11877377
18809224
11850621
9407949
18006705
|
PRKDC
|
CHEK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
77.0
|
1.0
|
Omnipath
|
31959038
12607004
22669845
18948271
16794575
24492479
15829965
23684611
12805407
20406977
26929199
21482692
27818175
20660628
33870196
11668173
21731742
33879618
15618221
11901158
24421316
21099343
12386164
15096610
24415760
12447382
12855706
15213307
16150728
20599567
16024600
17570479
12447371
28750002
34244606
33901880
15367709
26505995
16940182
33747205
11025670
12024051
24844881
15668230
10973490
20713355
33961649
19151762
16936775
16798742
12607003
30001349
18644861
25361978
20305300
11390408
20501833
15361851
16982735
23380594
15674326
17237275
20160490
20498628
33851958
15282313
25550082
31609975
15975956
11085506
12493754
|
CHEK2
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
111.0
|
1.0
|
Omnipath
|
18778462
25545885
16893723
15254178
18833288
23892398
12052256
18319725
25372714
15459660
20514219
25174607
28140789
17339337
22420423
18566216
20950777
20651945
15810020
15700044
22891162
17157788
11551930
18725978
10724175
15467443
23351141
20096447
11063934
11709713
15659650
12242661
10656682
15140942
20041275
11728459
18614044
12781359
22649771
18812180
11173129
10570149
15279785
20081365
20860841
11875057
22778557
19923893
24553354
22797063
26384650
23316480
15489221
19788416
10801407
21187893
9843217
9733514
10710310
24358900
21526939
23843721
29805302
9733515
25404613
12548019
21625617
10673501
11447225
17118344
26610585
19544417
28038466
12810724
25823026
15024084
17464182
15862297
19933256
20526329
12111733
20183804
23144912
|
CHEK2
|
FOXM1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
17101782
|
CHEK2
|
E2F1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
20.0
|
1.0
|
Omnipath
|
22558186
27679857
15140942
12717439
23219173
19473886
20860841
15838517
20603083
|
CHEK2
|
MDM4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
33.0
|
1.0
|
Omnipath
|
18356162
26095524
20651945
19808970
16511560
23277204
20860841
16511572
23002429
16163388
15788536
16227609
29065514
19573810
28690977
22120712
16943424
19432880
19075013
|
CHEK2
|
MDM2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
15862297
10710310
|
CHEK2
|
XRCC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
18566216
18971944
17464182
15810020
24947324
20471329
15459660
19497792
|
DCLRE1B
|
MUS81
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
18469862
|
DCLRE1B
|
TERF2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
21217703
18468965
20479256
26496610
16606622
18469862
16730175
|
XRCC6
|
DCLRE1C
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
11955432
16600297
16093244
16914548
|
XRCC5
|
DCLRE1C
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
11955432
16600297
16093244
16914548
|
XRCC4
|
DCLRE1C
|
â—¼ PHYSICAL_INTERACTION
|
|
|
13.0
|
1.0
|
Reactome
|
16439204
17470781
22529269
15451442
14561766
12077346
10757784
9259561
16439205
11702069
18046455
9430729
12509254
|
DCLRE1C
|
POLM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
13.0
|
1.0
|
Reactome
|
16439204
17470781
22529269
15451442
14561766
12077346
10757784
9259561
16439205
11702069
18046455
9430729
12509254
|
DCLRE1C
|
POLL
|
â—¼ PHYSICAL_INTERACTION
|
|
|
13.0
|
1.0
|
Reactome
|
16439204
17470781
22529269
15451442
14561766
12077346
10757784
9259561
16439205
11702069
18046455
9430729
12509254
|
PRKDC
|
DCLRE1C
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
18.0
|
1.0
|
Omnipath
|
17242184
15723659
11955432
16600297
23163657
22529269
16874298
21641068
19423708
15936993
1660029
|
TP53
|
E2F1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
21715977
20805247
8557038
11795482
17210690
22952705
|
E2F3
|
E2F1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
14576826
7958836
12063292
|
E2F1
|
PPARG
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
15711575
12110166
20971808
|
E2F1
|
CCNA2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
7623816
11264255
9178900
20580656
14681231
10594784
24335704
|
E2F1
|
SKP2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
16331253
23352642
22372491
24574749
20424123
17471231
23348237
17483325
|
E2F1
|
MYC
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
8208548
2721961
7753559
11705881
24038073
8355712
1549358
1567856
12629508
|
E2F1
|
TP53
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
22241525
8557038
15706352
21441950
12675512
23954287
12625370
|
TOPBP1
|
E2F1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
21.0
|
1.0
|
Omnipath
|
20413589
18660752
14576433
17006541
12697828
14576432
|
CDK6
|
E2F1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
18.0
|
1.0
|
Omnipath
|
9190208
10498883
18590585
7575488
9315635
17303408
10385618
10778858
9736735
16236519
20068082
7736585
9425340
11520855
19075565
18786381
17660363
15279786
|
CCND2
|
E2F1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
18.0
|
1.0
|
Omnipath
|
9190208
10498883
18590585
7575488
9315635
17303408
10385618
10778858
9736735
16236519
20068082
7736585
9425340
11520855
19075565
18786381
17660363
15279786
|
CCNA2
|
E2F1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
15840440
16135794
9736735
15133492
15558010
15123636
9556498
12501191
16213134
11980909
16123593
|
CCNA1
|
E2F1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
20.0
|
1.0
|
Omnipath
|
17660363
15840440
16135794
18590585
7575488
17303408
9736735
15133492
15558010
15123636
9556498
10022926
16213134
11980909
16123593
11739724
15279786
|
E2F1
|
CCNB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
15510213
7575488
18590585
17303408
18319725
17660363
15279786
|
E2F1
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
22480684
11739724
12625370
|
MSH2
|
EME1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
20.0
|
1.0
|
ACSN
|
10882712
12947387
15703371
16612326
16697054
17036055
18157157
18406444
18469862
19473888
19595721
19596235
19596236
19686080
19772495
19805513
19847258
20478261
20655466
22101340
|
STAT3
|
EME1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
34.0
|
1.0
|
ACSN
|
10347215
12223527
12947387
14607900
14670306
15218058
15356132
15573129
16418395
16697054
18776941
19380816
19473888
19595721
19596235
19596236
19686080
19772495
19847258
20093776
20237412
20406969
20581311
21840487
21922195
23124025
23454751
23589330
23850759
23953057
24857661
27216177
28186502
7543512
|
EME1
|
MUS81
|
â—¼ PHYSICAL_INTERACTION
|
|
|
20.0
|
1.0
|
ACSN
|
10882712
12947387
15703371
16612326
16697054
17036055
18157157
18406444
18469862
19473888
19595721
19596235
19596236
19686080
19772495
19805513
19847258
20478261
20655466
22101340
|
MSH2
|
EME1
|
â—¼ SHARES_COMPLEX
|
|
|
20.0
|
1.0
|
ACSN
|
10882712
12947387
15703371
16612326
16697054
17036055
18157157
18406444
18469862
19473888
19595721
19596235
19596236
19686080
19772495
19805513
19847258
20478261
20655466
22101340
|
STAT3
|
EME1
|
â—¼ SHARES_COMPLEX
|
|
|
34.0
|
1.0
|
ACSN
|
10347215
12223527
12947387
14607900
14670306
15218058
15356132
15573129
16418395
16697054
18776941
19380816
19473888
19595721
19596235
19596236
19686080
19772495
19847258
20093776
20237412
20406969
20581311
21840487
21922195
23124025
23454751
23589330
23850759
23953057
24857661
27216177
28186502
7543512
|
EME1
|
MUS81
|
â—¼ SHARES_COMPLEX
|
|
|
20.0
|
1.0
|
ACSN
|
10882712
12947387
15703371
16612326
16697054
17036055
18157157
18406444
18469862
19473888
19595721
19596235
19596236
19686080
19772495
19805513
19847258
20478261
20655466
22101340
|
POLM
|
EME1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
10.0
|
1.0
|
ACSN
|
15703371
16697054
16738138
17483519
17631059
19346677
19473888
19772495
19808869
19847258
|
AKT2
|
EP300
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
17964260
16926151
|
SIRT1
|
EP300
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
15632193
19047049
|
MAPK1
|
EP300
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
17623675
24530506
|
EP300
|
FEN1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
19608861
11430825
|
EP300
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
137.0
|
1.0
|
Omnipath
|
11907332
25545885
21187340
10706102
16438982
10490106
19339993
15542844
23010591
11433299
19608861
17438265
17906639
16024799
9194564
20234175
23402884
12162806
26229107
16959611
15186775
9744860
11070080
17977830
17189186
22266186
20228809
15664194
19805293
25753752
11804596
26625199
27818144
10648616
16928824
9288740
10942770
12724314
23148227
23728348
15965232
19218448
16678111
16782091
20094059
14612423
24821727
10518217
16713569
9891054
25288747
17452980
14759370
19788416
25156994
18931695
22074660
23880760
15337767
15509808
26302407
22731250
18391200
16543236
19234109
21471221
23307557
25867071
12690203
15558054
18612383
23870121
18243116
19217391
22013068
16537920
16611888
18485870
9194565
12660246
9809062
23796514
11359905
12501250
15295102
19407812
25651062
23329847
16135789
|
EP300
|
STAT3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
25.0
|
1.0
|
Omnipath
|
18782771
15509516
8756628
10205054
7530500
15653507
15735682
19506034
16285960
16713569
11322950
7499365
15649887
9590694
|
EP300
|
H3C2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
21875947
19270680
19158375
20587414
|
EP300
|
NBN
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
20471956
16051665
21108945
|
EP300
|
CCND2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
17306568
17666529
23343194
21285352
15576399
21151179
22761862
22290435
16039586
19619488
19623618
17143292
|
EP300
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
19.0
|
1.0
|
Omnipath
|
17145710
22290435
19623618
11804596
23343194
22761862
16039586
12776737
17157259
17143292
12660246
15576399
21151179
15522869
17306568
19407812
17666529
21285352
19619488
|
ERCC6
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
16713569
10882116
19221478
18784753
|
NBN
|
FEN1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
9.0
|
1.0
|
Reactome
|
25642960
25789972
11440997
25643323
20483915
25642963
15135726
16012167
11340072
|
FEN1
|
RBBP8
|
â—¼ PHYSICAL_INTERACTION
|
|
|
9.0
|
1.0
|
Reactome
|
25642960
25789972
11440997
25643323
20483915
25642963
15135726
16012167
11340072
|
FEN1
|
RAD50
|
â—¼ PHYSICAL_INTERACTION
|
|
|
9.0
|
1.0
|
Reactome
|
25642960
25789972
11440997
25643323
20483915
25642963
15135726
16012167
11340072
|
FEN1
|
MRE11
|
â—¼ PHYSICAL_INTERACTION
|
|
|
9.0
|
1.0
|
Reactome
|
25642960
25789972
11440997
25643323
20483915
25642963
15135726
16012167
11340072
|
MYC
|
FOXM1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
20658516
18798339
12695333
17341548
|
FOXM1
|
CCNB1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
11572993
19276163
15671063
11682060
19097132
23812424
|
FOXM1
|
CCNB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
15817462
15689977
10567581
11572993
11682060
15024056
11391529
|
FOXM1
|
AURKB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
15817462
15689977
17173139
16314512
|
FOXM1
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
17141659
10567581
17655499
16965535
11391529
|
FOXM1
|
SKP2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
16585184
16314512
|
MDM2
|
FOXO3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
14.0
|
1.0
|
ACSN
|
11715018
11779693
11923280
14761977
15024084
15084260
15169778
15876864
16307918
17110379
17158541
19321440
20679392
9450543
|
FOXO3
|
SIRT1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
23525956
20816089
15604409
23262029
|
MAPK1
|
FOXO3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
8.0
|
1.0
|
Omnipath
|
18204439
29445193
22128155
10102273
|
AKT2
|
FOXO3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
18.0
|
1.0
|
Omnipath
|
19951971
19216069
17680028
11756412
17646672
20214616
11463845
20452955
9829964
20398329
10102273
18593906
16680151
10217147
19188143
|
AKT3
|
FOXO3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
20.0
|
1.0
|
Omnipath
|
15023346
19951971
19216069
17680028
11756412
17646672
20214616
11463845
23109003
20452955
9829964
20398329
10102273
18593906
16680151
10217147
19188143
|
SIRT1
|
FOXO3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
12.0
|
1.0
|
Omnipath
|
24003218
14976264
14980222
15126506
21713995
15917664
|
MAPK14
|
FOXO3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
22128155
23857333
|
FOXO3
|
CDKN2B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
19.0
|
1.0
|
Omnipath
|
9308237
17936558
18644865
19380174
10783894
11283613
16288288
17873901
20673124
11094066
21708191
17646672
15084260
15509806
21613825
17940099
11994454
11154281
|
HRAS
|
GRB2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
Reactome
|
19946327
11429702
11157491
18757403
21666749
21711248
18381441
19103595
21160078
9857065
20179196
|
KRAS
|
GRB2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
Reactome
|
19946327
11429702
11157491
18757403
21666749
21711248
18381441
19103595
21160078
9857065
20179196
|
NRAS
|
GRB2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
Reactome
|
19946327
11429702
11157491
18757403
21666749
21711248
18381441
19103595
21160078
9857065
20179196
|
GRB2
|
PIK3R1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
32.0
|
1.0
|
ACSN
|
10086337
10567412
10811803
10849428
10982827
11335727
11447289
11449354
11532940
11777939
12175651
12393695
12640133
15308668
15567848
15574420
16000375
16076871
16530705
16582911
16887996
17496910
17673906
18835194
19449109
19454690
22064427
22464172
24217602
25922287
26552706
8551221
|
GRB2
|
MAP2K6
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
34.0
|
1.0
|
ACSN
|
10086337
10567412
10811803
10982827
11274345
11447289
11777939
12040186
12175651
12419216
12640133
12738796
12782630
14585353
15567848
15574420
15863030
16102570
16227978
16488589
16582911
16887996
17496910
17673906
18855897
19449109
19568798
19615955
21102635
21614932
24027568
26552706
7510700
8551221
|
GRB2
|
HRAS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
17496910
16713569
17673906
11352655
|
KDM4A
|
HERC2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
19203579
22589545
22980979
18001825
19203578
18001824
18006705
|
KDM4B
|
HERC2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
19203579
22589545
22980979
18001825
19203578
18001824
18006705
|
HERC2
|
XRCC6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
22179609
11493912
9512523
11604075
12947387
|
HERC2
|
XRCC5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
22179609
11493912
9512523
11604075
12947387
|
HERC2
|
PAXIP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15468306
15574327
23333306
23306437
15723659
23727112
|
HERC2
|
RNF8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
20023648
22508508
25305019
22814251
|
HERC2
|
RNF168
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
20023648
|
TP53
|
HMGB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
9472015
23063560
11748221
16713569
11106654
|
HMGB1
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
9472015
23063560
11748221
16713569
11106654
|
TP53
|
HSP90AA1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
15358769
15284248
24451373
18996350
|
HDAC6
|
HSP90AA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
19158084
18591380
18266962
|
STAT3
|
HSP90AA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
18266962
16189514
12559950
|
HSP90AA1
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
12427754
10557093
21460846
16713569
11507088
|
HSP90AA1
|
PPP5C
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
10400612
16531226
21360678
15577939
15383005
|
XRCC6
|
KAT5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
22179609
11493912
9512523
11604075
12947387
|
PAXIP1
|
KAT5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15468306
15574327
23333306
23306437
15723659
23727112
|
XRCC5
|
KAT5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
22179609
11493912
9512523
11604075
12947387
|
KAT5
|
RBBP8
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
22021381
16153896
18923075
18805091
21325134
22792074
19419957
21052091
18971343
25122754
11301010
21240188
|
KAT5
|
PRKDC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
16603769
16904321
|
KAT5
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
17188038
15310756
18280244
16601686
|
KAT5
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
12776177
19150978
15572685
34650217
|
KAT5
|
STAT3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
12551922
16713569
|
XRCC1
|
LIG3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
34.0
|
1.0
|
ACSN
|
11900249
12648680
14726013
15703371
16697054
17088286
17116881
17884153
18524993
19208614
19362533
19364882
19809470
19847258
20056333
20211143
20227374
20603072
21270334
21376743
22055391
22469522
22713970
22743550
22921416
23145148
23562323
23568489
24050180
24210699
24684389
24976506
8264637
8978692
|
XRCC1
|
LIG3
|
â—¼ PROTEIN_INTERACTION
|
|
|
34.0
|
1.0
|
ACSN
|
11900249
12648680
14726013
15703371
16697054
17088286
17116881
17884153
18524993
19208614
19362533
19364882
19809470
19847258
20056333
20211143
20227374
20603072
21270334
21376743
22055391
22469522
22713970
22743550
22921416
23145148
23562323
23568489
24050180
24210699
24684389
24976506
8264637
8978692
|
LIG3
|
XRCC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
18.0
|
1.0
|
Omnipath
|
9705932
20227374
17353931
11163244
26496610
16713569
8264637
11352725
9136882
|
GADD45G
|
MAP2K6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
17145710
11175814
21614932
12738796
11274345
12213961
18855897
|
GADD45B
|
MAP2K6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
17145710
11175814
21614932
12738796
11274345
12213961
18855897
|
MAP2K6
|
MAPK13
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
23331499
11242034
8663074
10201954
21614932
12738796
11274345
9218798
9790884
18855897
|
MAP2K6
|
MAPK14
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
96.0
|
1.0
|
Omnipath
|
10480932
19901323
17081983
7914033
9362518
18767875
17322306
8622669
18855897
16342939
16497976
15592455
8974401
7997261
15735649
18291705
23331499
8626699
21071413
16083285
21614932
18452278
12738796
20068231
9808624
11727828
16189514
18988627
17255949
9790884
16153436
18669648
26538579
14970210
16282370
11242034
18691976
18088087
11304531
15972258
10781613
17192257
18586681
10734320
20551513
19651622
15212693
7592586
16157584
21402774
9582275
15674326
9528766
7693711
12758252
11309380
7750576
17255097
17016520
15659558
11274345
15735648
|
NRAS
|
MAPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
HRAS
|
MAPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
MAPK1
|
MAP2K2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
11802164
15239952
21779496
11802165
15260967
|
NPM1
|
MAPK1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
31434245
22955283
12748172
16009132
|
ETS1
|
MAPK1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
Reactome
|
8552081
10358095
20534573
11782450
15572696
|
MYC
|
MAPK1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
22789855
21933022
16596619
23617883
8013639
20144848
|
MAP2K2
|
MAPK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
68.0
|
1.0
|
Omnipath
|
21675959
11704645
9694850
17081983
7565670
12750173
19690332
12932319
11823456
18799465
15592455
11337027
18083107
21365009
12788955
11134045
19219045
17389395
9447970
15342917
23331499
19534553
17569879
7559390
23047924
8226933
8223433
17272394
15851026
15811950
19494114
18988627
18669648
11549292
23519423
19541618
18691976
1381507
16293107
17906627
11986622
19933846
8376945
19053285
16094384
11971971
17192257
11136732
11948414
8388392
7898932
9731057
11730323
18039929
11118451
19369195
12920017
15951569
15466214
10746662
|
MAPK14
|
MAPK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
20.0
|
1.0
|
Omnipath
|
15187187
21675959
18039929
12738796
11157753
22521293
17255949
11238443
11274345
12697810
|
MAPK13
|
MAPK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
12738796
18039929
11274345
15187187
|
MAPK1
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
12975377
23602568
16424009
19058874
23397142
21707490
|
MAPK1
|
ETS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
21494553
21449613
25241761
16045329
23991633
20361728
11570862
22521293
11948414
|
MAPK1
|
PPARG
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
21.0
|
1.0
|
Omnipath
|
25409419
11733495
16574647
9099735
9030579
15507114
26670611
17570479
17998334
18596912
|
MAPK1
|
STAT3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
59.0
|
1.0
|
Omnipath
|
18448488
19413330
11335711
9343414
15465816
25584415
12576423
11350938
20068231
12681450
12763138
9872331
11780390
18491316
18669648
11404481
10521505
18691976
20058876
15979846
14551213
10446219
|
MAPK1
|
EIF4EBP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
73.0
|
1.0
|
Omnipath
|
17081983
11691836
18767875
11553333
12665511
25702871
19413330
10405182
18187866
19664995
12747827
10942774
9092573
15051500
20068231
9465032
27387559
11410517
11777913
18669648
8083223
12105188
17386266
25762619
17287340
9405468
12588975
12370290
19651622
10779345
27402756
10364159
11799119
26170285
12912989
33658337
16339216
12759354
|
MAPK1
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
17.0
|
1.0
|
Omnipath
|
10551811
17081983
8386367
17251036
91332050
17570479
1748630
7957875
27167001
15212693
1651323
15210690
|
MAPK1
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
29.0
|
1.0
|
Omnipath
|
14965474
9765199
15116093
21675959
23443559
10781582
25241761
10446957
10958792
11409876
11709713
21147777
10673501
11551930
15867353
11875057
12091386
|
MAPK1
|
MKNK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
28.0
|
1.0
|
Omnipath
|
10655591
15547943
20080742
12040186
15173823
12697810
11940578
16227978
23047924
9155017
10922375
12738796
16039586
17255949
15187187
19541618
19091303
19565474
17052211
10022874
32296183
18039929
18775330
10601235
12792650
11431469
|
MAPK1
|
MAPKAPK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
21675959
22028470
15094067
8846784
23047924
25255283
12861023
7592979
1327754
8995385
|
MAP2K3
|
MAPK14
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
91.0
|
1.0
|
Omnipath
|
12589052
11279118
17081983
20213747
7914033
18767875
17322306
23602568
8622669
18855897
19690332
23904011
9162092
11426938
15592455
18083107
7997261
12384504
15735649
18291705
23331499
17389395
7535770
19534553
7839144
21071413
16083285
21614932
20068231
12738796
16189514
17255949
18669648
16153436
14970210
26186194
16407200
11242034
18691976
18088087
11304531
15972258
10781613
17192257
18586681
10734320
19651622
7592586
16157584
19369195
9582275
15674326
9528766
7693711
9841871
12758252
11309380
7750576
15212693
15659558
11274345
15735648
|
MAPK14
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
18.0
|
1.0
|
Omnipath
|
15187187
21675959
18039929
12738796
23397142
11238443
11274345
12697810
|
MAPK14
|
MKNK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
27.0
|
1.0
|
Omnipath
|
23602568
10655591
17590453
23331499
23047924
9155017
10922375
12738796
15550948
15187187
20936779
26186194
10022874
18039929
9155018
11157753
11274345
23455922
|
MAPK14
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
57.0
|
1.0
|
Omnipath
|
21675959
26247731
20213747
17535811
20506250
15657900
9315650
15642743
19413330
11283254
22975381
10581258
16083285
1088347
21614932
16393692
10884347
21050851
16552184
10747897
15187187
17906639
25789565
15140942
11258706
24818748
19436832
10781582
10212189
17172861
10348343
11078726
11274345
|
MAPK14
|
STAT3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
23331499
10201984
18691976
17502367
17570479
|
MAPK14
|
EIF4EBP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
35.0
|
1.0
|
Omnipath
|
17081983
11691836
18767875
12665511
17043358
19413330
10405182
19664995
10942774
9092573
20068231
9465032
11777913
18669648
8083223
12105188
17287340
9405468
12370290
19651622
10779345
10364159
12912989
|
MAPK14
|
H3C2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
20626350
11278789
|
MAPK14
|
MAPKAPK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
63.0
|
1.0
|
Omnipath
|
21675959
16456544
23602568
17395714
21988832
10581204
23331499
21071413
27898710
23047924
10922375
12738796
11551945
26496610
25852190
18988627
15629715
18669648
15187187
11042204
26186194
25241761
8846784
17906627
14499342
9922370
7923353
9768359
18039929
25255283
7592979
17255097
11274345
23455922
|
MAPK14
|
MAP2K2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
12738796
18039929
11274345
15187187
|
MAPK14
|
CCND2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
17486076
27843138
|
KRAS
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
NRAS
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
HRAS
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
MAPK3
|
MAP2K2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
11802164
15239952
21779496
11802165
15260967
|
ETS1
|
MAPK3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
Reactome
|
8552081
10358095
20534573
11782450
15572696
|
MAP2K2
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
101.0
|
1.0
|
Omnipath
|
19901323
17081983
11704645
9694850
12750173
1411546
19690332
12932319
18799465
16497976
18083107
11134045
8626767
9006895
17389395
19219045
15342917
9447970
16887817
23331499
17569879
7867743
7559390
21071413
19534553
8226933
20068231
8223433
17272394
93330262
15851026
15811950
26987942
18988627
19494114
18669648
19541618
11242034
15466476
18691976
1381507
17906627
11986622
19933846
8376945
11971971
17192257
11136732
11948414
7898932
7687743
9731057
19651622
11730323
16464493
18983981
11251083
11118451
15580310
19369195
18707149
12920017
15951569
15466214
10746662
15212693
|
MAPK13
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
12738796
18039929
11274345
15187187
|
MAPK3
|
MKNK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
37.0
|
1.0
|
Omnipath
|
15547943
20080742
12040186
15173823
12697810
11940578
23331499
16227978
8226933
9155017
12738796
16039586
17255949
15187187
19541618
19091303
19565474
17052211
10022874
8388392
18039929
9155018
18775330
9604935
10601235
12792650
11431469
|
MAPK3
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
23331499
18463697
9155018
21071413
32482868
18988627
15210690
|
MAPK3
|
STAT3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
73.0
|
1.0
|
Omnipath
|
18448488
19413330
11335711
9343414
23331499
15465816
25584415
12576423
11350938
20068231
12681450
10417333
12763138
9872331
18988627
11780390
18491316
18669648
11404481
10521505
18691976
19723038
20058876
14551213
10446219
|
MAPK3
|
HDAC6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
24089523
|
MAPK3
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
18.0
|
1.0
|
Omnipath
|
10781582
11239457
10958792
28937686
9467949
10348343
24194938
9739174
16713569
12955074
10747897
17237827
25767119
18523266
12393879
|
MAPK3
|
MAPKAPK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
21675959
17242355
7592979
14499342
14967450
23583303
|
MAPK3
|
ETS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
8761310
23331499
12048211
11948414
|
MAPK3
|
PPARG
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
18596912
11733495
|
MAPK13
|
MAPKAPK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
12738796
18039929
11274345
15187187
|
MAPKAPK2
|
MDM2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
19738896
15688025
|
XRCC5
|
MDC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
22179609
11493912
9512523
11604075
12947387
|
RAD50
|
MDC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
59.0
|
1.0
|
ACSN
|
11331603
11850621
11877377
12086603
12556884
12607003
14614141
14988723
15136767
15140942
15175241
15242590
15279786
15375219
15377654
15459660
15485915
15798197
15964794
16163361
16332722
16531125
16713580
16805667
16818604
16858402
17102137
17116885
17296725
17303408
17384638
17582221
17660363
18006705
18087292
18469862
18543256
18583988
18584027
18590585
18678890
18809224
18995830
19151707
19282663
19342888
19622404
19686080
19772495
19793801
20051983
20723763
21376743
22743550
23847781
24050180
7575488
9407949
9488723
|
XRCC6
|
MDC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
22179609
11493912
9512523
11604075
12947387
|
MDC1
|
RNF8
|
â—¼ PHYSICAL_INTERACTION
|
|
|
27.0
|
1.0
|
ACSN
|
12607003
15279786
15459660
15496928
15549137
15655342
17303408
17660363
18001824
18001825
18006705
18087291
18171670
18212739
18583988
18590585
18678709
18678890
18809224
19217833
19270065
19490890
19772495
20021983
20064462
7575488
9407949
|
MDC1
|
PAXIP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15468306
15574327
23333306
23306437
15723659
23727112
|
MDC1
|
RNF8
|
â—¼ PROTEIN_INTERACTION
|
|
|
27.0
|
1.0
|
ACSN
|
12607003
15279786
15459660
15496928
15549137
15655342
17303408
17660363
18001824
18001825
18006705
18087291
18171670
18212739
18583988
18590585
18678709
18678890
18809224
19217833
19270065
19490890
19772495
20021983
20064462
7575488
9407949
|
RAD50
|
MDC1
|
â—¼ SHARES_COMPLEX
|
|
|
59.0
|
1.0
|
ACSN
|
11331603
11850621
11877377
12086603
12556884
12607003
14614141
14988723
15136767
15140942
15175241
15242590
15279786
15375219
15377654
15459660
15485915
15798197
15964794
16163361
16332722
16531125
16713580
16805667
16818604
16858402
17102137
17116885
17296725
17303408
17384638
17582221
17660363
18006705
18087292
18469862
18543256
18583988
18584027
18590585
18678890
18809224
18995830
19151707
19282663
19342888
19622404
19686080
19772495
19793801
20051983
20723763
21376743
22743550
23847781
24050180
7575488
9407949
9488723
|
MDC1
|
RNF8
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
27.0
|
1.0
|
ACSN
|
12607003
15279786
15459660
15496928
15549137
15655342
17303408
17660363
18001824
18001825
18006705
18087291
18171670
18212739
18583988
18590585
18678709
18678890
18809224
19217833
19270065
19490890
19772495
20021983
20064462
7575488
9407949
|
MDC1
|
TP53BP1
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
13.0
|
1.0
|
ACSN
|
12607003
15279786
15459660
17303408
17660363
18001824
18006705
18087291
18583988
18590585
18678890
7575488
9407949
|
MDC1
|
TP53BP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
16009723
17145710
18087291
17925396
12607005
|
MDC1
|
RNF8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
18.0
|
1.0
|
Omnipath
|
24240613
18001824
25512560
18001825
18678647
18082599
18006705
|
MDC1
|
NBN
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
22.0
|
1.0
|
Omnipath
|
17145710
15201865
20460517
23115235
14519663
18001824
18678890
19804756
18583988
19230643
12607003
12607005
20224574
|
TP53
|
MDM2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
201.0
|
1.0
|
Omnipath
|
23150757
20948295
10871862
10914734
21422812
21957016
14532965
22290440
20663877
20547751
11591713
24339722
11840331
22223137
16492744
15843377
22948151
7888679
20156675
21217645
22180176
8319905
9707425
15831521
17690113
9649502
10688649
9194564
15917661
15090541
20837136
8187772
10788589
17907153
15192123
8440237
11964305
16510138
10856296
15580300
7624148
12208736
21211512
16624812
17848574
11245471
21637567
20588255
10562557
9525742
9270029
16479015
19941079
14602726
15024021
18814047
20036872
10718212
18852133
12374749
18397889
25016801
12755686
22081073
22245141
23365201
8957072
22197810
15856024
20703075
23483203
9645455
19648117
20331637
22301280
14743206
23982177
9486848
15734740
19638633
19671680
17310983
10469568
20659896
10072445
21097889
17237821
11748232
11085543
21750655
16337599
21295542
1614537
9815889
9070662
16585169
9472631
17936559
17139261
11328884
12887889
20858413
9858609
14610316
20080970
19505873
11313463
15684615
18359851
18783169
16202543
9267820
12235242
14990790
15851483
7587074
18336191
21478269
17043642
15361831
18025460
23612020
10208414
11756653
24389645
9071998
9430645
9400998
9371494
23149414
22532570
9271120
10777217
22383580
18781178
12606552
14514686
17318220
11127813
16571800
19085961
9207798
10891494
10065155
11593391
14570892
12902982
19649205
20124454
17390010
19955655
12138177
19663772
23581014
15908423
10321740
23150759
19837670
10348346
18632610
9294611
11956627
12750288
12851404
8313378
9135153
15735665
7958853
8247544
9535786
16501602
18566224
8910340
11046142
9405685
7936649
12173040
17329361
21451571
14704432
23874713
18333294
19541936
22787160
18585004
22085928
12080472
7651818
11179471
10949923
19428175
15592502
8413278
11714701
10566557
18583933
9681831
15550242
15007388
19590512
|
MYC
|
MDM2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
15655352
12695333
19649205
10348347
|
USP7
|
MDM2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
36.0
|
1.0
|
Omnipath
|
17145710
17936559
26460617
15916963
24462112
22056774
18566590
20816748
16402859
20713061
16943424
17380154
29236775
16082221
26238070
34799561
16845383
16474402
28406480
27452404
28196907
|
DAXX
|
MDM2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
17.0
|
1.0
|
Omnipath
|
17145710
21134643
16845383
15364927
18566590
23405218
18583933
20195357
23038753
|
NCL
|
MDM2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
24147044
16751805
22103682
20195357
|
AKT3
|
MDM2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
19216069
17680028
11756412
16680151
20214616
11463845
20452955
9829964
20398329
17646672
10217147
|
AKT2
|
MDM2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
19216069
17680028
11756412
16680151
20214616
11463845
20452955
9829964
20398329
11504915
17646672
10217147
|
MDM2
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
559.0
|
1.0
|
Omnipath
|
20657550
30005830
17616658
9529249
10321734
33650658
9724739
24462112
24621507
15933712
23826318
24667498
22948151
22653443
23776060
25313037
25241761
19303885
16857591
23246961
19033382
20591651
21149449
25417702
15122315
16579792
27543608
29670376
12208736
17848574
26673821
25277184
23443559
23318437
21060154
15210108
19805293
8875929
8058315
21471462
17879958
25362358
23169665
22301280
21584881
20124408
10980696
26876197
17310983
17380154
15058298
24567357
18665269
30109812
25637791
18467333
22337874
22227409
22389628
15242646
22510990
15950904
15001357
19483087
26540344
14559824
21986495
26556313
20708156
19901969
33765973
32528731
11562347
10202144
22374672
10722742
22083959
21965653
17098746
19234109
30679555
16107876
12690203
22525275
19071110
28542145
12620407
20837658
27129163
9131587
24240685
27031960
10681559
19305137
11744695
19188367
16023600
24659749
17347673
12944468
20395212
22084066
20639885
21454483
12897156
16432196
10347217
10706102
11178989
20174603
16751805
15542844
12842086
11431470
11384992
25739118
15064742
23402884
27462439
16905769
22124327
27215386
12867035
22588298
27336364
14702041
16152627
23776465
22262183
21132010
19411846
18309296
23483203
11709713
18981217
14612427
22920093
23671280
24980433
27905468
25168242
21750659
26238070
22737255
23609977
27282385
20847049
20705607
21075307
28082682
17297477
11697899
17936559
24361594
19098711
15469934
34591612
24998844
16212962
11094089
12915590
17116689
11713288
15144954
23201157
10608892
17591690
25156994
17301054
22444248
26883110
26001071
19160491
22157679
24413661
19357310
23802716
15280377
21317885
11597128
19579266
25624478
18061646
21088494
9223638
10435614
31177307
11331603
22391559
20570896
19941302
9278461
18485870
15604276
18566590
12612087
11046142
14704432
26186194
10935507
16173922
14596917
17159902
25543083
19656744
15848166
18316739
22266868
17056014
19255450
21561866
19590512
11839577
22991965
22266850
24200963
11285227
11713287
22975381
19081178
20660730
26475964
16678796
23261415
20173098
17666403
25464845
32427887
23252402
17438265
20959462
22659184
17470788
22912717
17080083
15247280
19332559
17989425
16870621
18813780
20235143
11278372
10562557
25609649
10561590
19411066
17908790
19568783
7926727
21925390
21988832
24127580
18604177
14499615
17371838
17525743
33061576
21887275
26578655
21084564
16861890
20694676
12552135
22914926
17363365
24643130
1614537
22916255
12381304
34992144
12167711
19857530
15053879
10889512
11486026
22103682
16713569
17110336
17426254
10640350
21316347
21478269
15154850
12529318
16595680
16414131
19597489
23880345
27893708
7686617
27811966
17318220
29997244
27308622
19166840
35044719
16159876
24314634
15313915
25283148
22032989
24926618
18172499
19837670
16215989
23134341
26908445
9824166
18451149
21170087
23572512
21465263
22807444
15013777
16845383
10488081
23946421
11714701
25384516
22474335
25312347
23370271
23150757
18541670
22318540
11925449
21572037
24488098
32066565
17268548
20542919
11572869
16338390
21857681
23150668
19223463
20234175
20484049
11070080
20591429
22575647
11351297
16624812
22411991
20588255
17369817
11223036
15908921
9582019
25103245
17302414
21071676
9450543
31968249
34562520
18332869
14671306
21084285
27856536
30464405
26882543
21726810
33020477
21261729
21268072
12426395
16964247
20659896
19106616
22331460
23728348
10827196
22524527
21098709
9363941
17139261
20080206
14517261
22487680
31652301
17290220
27106262
16866370
24207125
28223335
9271120
15550400
7689721
26350565
10196247
27807478
10766163
15558054
35371302
26203195
29487367
25512388
25954860
18223694
15824742
24842904
14741215
16055726
22085928
32894144
18234963
17875722
18815136
15295102
15308643
15358376
22819825
15094782
|
MDM2
|
MDM4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
69.0
|
1.0
|
Omnipath
|
17145710
10218570
17616658
16511560
22266850
12874296
21925390
25825738
21988832
25512388
16227609
22493164
22902369
25659040
18219319
12963717
15604276
18566590
12370303
19838211
26359458
27617579
25809483
34551723
10608892
23028042
22120712
25703327
12860999
32300648
16055726
24813712
17301054
12483531
23671280
17159902
27621617
25105592
20484049
20724842
27215386
10827196
26001071
11606419
23946421
19683495
20705607
24755078
25384516
20473904
12393902
|
TP53
|
MDM4
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
16492744
18172009
21750655
20036872
21422812
17510313
9926934
18336191
19521340
20372076
10469568
20080970
22290440
21394211
23474762
|
USP7
|
MDM4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
20713061
35044719
18566590
15916963
16082221
|
MDM4
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
74.0
|
1.0
|
Omnipath
|
25609649
18677113
28487147
24445145
30045945
20515689
26148237
22266850
11528400
19521340
21088494
16713569
15916963
9226370
12874296
21925390
16024788
25825738
24667498
16227609
24127580
8895579
20174603
18485870
12963717
15604276
25464845
12370303
10608892
23028042
25961923
26186194
17110929
22374672
26876197
17301054
23671280
21965653
17875722
22807444
10075736
19305137
17080083
29023092
27114532
20724842
10827196
19255450
24659749
28035068
23946421
20705607
19075013
21075307
12393902
11223036
|
MSH2
|
MUS81
|
â—¼ PHYSICAL_INTERACTION
|
|
|
20.0
|
1.0
|
ACSN
|
10882712
12947387
15703371
16612326
16697054
17036055
18157157
18406444
18469862
19473888
19595721
19596235
19596236
19686080
19772495
19805513
19847258
20478261
20655466
22101340
|
MSH2
|
MSH6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
26.0
|
1.0
|
ACSN
|
11307145
11948476
12556884
12947387
15136767
15703371
16332722
16612326
16697054
16713580
16858402
16879101
17129768
17303408
17395641
18157157
18406444
18543256
19151707
19473888
19595721
19596235
19596236
19847258
20478261
23507534
|
MSH2
|
MSH6
|
â—¼ SHARES_COMPLEX
|
|
|
26.0
|
1.0
|
ACSN
|
11307145
11948476
12556884
12947387
15136767
15703371
16332722
16612326
16697054
16713580
16858402
16879101
17129768
17303408
17395641
18157157
18406444
18543256
19151707
19473888
19595721
19596235
19596236
19847258
20478261
23507534
|
MSH2
|
MUS81
|
â—¼ SHARES_COMPLEX
|
|
|
20.0
|
1.0
|
ACSN
|
10882712
12947387
15703371
16612326
16697054
17036055
18157157
18406444
18469862
19473888
19595721
19596235
19596236
19686080
19772495
19805513
19847258
20478261
20655466
22101340
|
POLM
|
MSH2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
10.0
|
1.0
|
ACSN
|
15703371
16697054
16738138
17483519
17631059
19346677
19473888
19772495
19808869
19847258
|
MTOR
|
MYC
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
23.0
|
1.0
|
ACSN
|
12150925
12408816
12906785
15755954
16469695
17604271
17680028
18372248
18492954
19022819
19446321
19568798
19706736
19864431
21157483
21981924
23087689
24795729
24973821
25002027
25730849
26159692
28216025
|
MTOR
|
STAT3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
22.0
|
1.0
|
Omnipath
|
29228628
10660304
22408571
12796477
16740698
18691976
26573296
15522880
27384580
26775702
24423131
26241748
23055980
|
MTOR
|
AKT2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
20338882
17517883
18372248
19203586
27418134
17277771
15718470
26491696
|
MTOR
|
AKT3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
17517883
18372248
19203586
17277771
15718470
|
MTOR
|
EIF4EBP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
132.0
|
1.0
|
Omnipath
|
17510057
17081983
11691836
22873724
18767875
16824195
19147279
23077579
24303063
28272965
19690332
11438723
12665511
17043358
19413330
10405182
20670887
19209957
19664995
15070431
9826548
12747827
10942774
16242075
9092573
12604610
20068231
9465032
21190521
23360111
17991864
25686248
9204908
11777913
18669648
12150926
8083223
20537536
12105188
17386266
24205284
17517883
26985829
19291795
23972597
16288292
17487921
8895571
17287340
9405468
20227039
12588975
12370290
17717968
23486913
19651622
10779345
26255626
18220336
16404421
18283322
10364159
15066126
12912989
17693255
15767663
|
POLM
|
MUS81
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
10.0
|
1.0
|
ACSN
|
15703371
16697054
16738138
17483519
17631059
19346677
19473888
19772495
19808869
19847258
|
STAT3
|
MYC
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
33.0
|
1.0
|
ACSN
|
10347215
11875494
12193690
12223527
12907458
14607900
14670306
15218058
15356132
15465827
15573129
16418395
17404308
18776941
19380816
20093776
20237412
20406969
20435894
20580461
20581311
21372296
21765015
21840487
22461508
23124025
23390297
23454751
23953057
24857661
27216177
28186502
7543512
|
MYC
|
PPARG
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
22.0
|
1.0
|
ACSN
|
10432118
11274345
11283614
11875494
16327802
17558397
17873522
20027199
20237412
20551172
20581311
20713526
21093321
21372296
21406394
21765015
2191300
22067385
22461508
23124025
23390297
25002027
|
E2F4
|
MYC
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
24573694
17132729
17699159
11689553
12757710
|
STAT3
|
MYC
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
19289167
17204573
18184402
22317895
20067773
15184887
15469392
10464281
9325164
20654581
21573184
17959148
22349830
9874564
20581311
19259613
|
HNF4A
|
MYC
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
12591729
23714368
19966299
15024077
|
PPARG
|
MYC
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
11973610
17462534
16405739
19075513
|
MYC
|
CCNA2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
8386381
10713672
12835716
7608142
12937171
14519204
14729654
|
MYC
|
TP53
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
10962037
10656696
8494784
10348347
19882681
16557594
19086036
15780936
14519204
16112647
11781835
7969121
11789587
9839551
|
MYC
|
CCND2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
7526316
11511535
10508165
9339900
15988028
20857481
11060032
14519204
14660677
10956386
21790895
11264343
|
MYC
|
NPM1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
15589822
16857742
14519204
23271972
11983916
11085504
|
MYC
|
CCNB1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
12747840
11522645
11983916
19470724
|
MYC
|
CDKN2B
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
12.0
|
1.0
|
Omnipath
|
12244100
22610535
11804592
12565816
19164764
12835716
11283613
14519204
24618291
19201832
23722468
|
MYC
|
NCL
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
10606642
24951594
12695333
14519204
25018006
11983916
|
MYC
|
SKP2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
24259667
12963825
12769844
23792459
21245140
24177224
23277542
|
MYC
|
TRRAP
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
17848523
23775087
11511535
20194507
|
MYC
|
HSPA4
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
1534087
14519204
1562593
10446203
|
MYC
|
CDK6
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
20682794
22395148
12835716
|
SKP2
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
12.0
|
1.0
|
Omnipath
|
17145710
24259667
12963825
12769844
17157259
23277542
20852628
16376880
35260179
26038816
|
TRRAP
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
17145710
17353931
11511539
12660246
20194507
9708738
|
MAPK8
|
MYC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
25.0
|
1.0
|
Omnipath
|
19651622
10551811
17081983
18767875
20068231
91332050
1651323
1748630
16713569
11243879
18669648
15210690
|
MYC
|
CCND2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
8425218
15121849
11602341
2006410
17873522
21406394
12584560
17558397
20551172
15814658
16908182
|
MYC
|
CDKN2B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
16.0
|
1.0
|
Omnipath
|
10454538
10373560
9308237
17936558
12738781
17873522
11283613
21406394
9312026
15095404
10504341
17558397
20551172
19901969
19815509
11283614
|
MYH10
|
PPP1CB
|
â—¼ DEPHOSPHORYLATION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
9354661
8662509
11331307
11942626
|
NBN
|
BARD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
22021381
16153896
18923075
18805091
21325134
22792074
19419957
21052091
18971343
25122754
11301010
21240188
|
NBN
|
XRCC6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
22179609
11493912
9512523
11604075
12947387
|
MRE11
|
NBN
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
24.0
|
1.0
|
Omnipath
|
17145710
22464731
26455393
12861053
17500065
15734743
12419185
19270065
22078559
19244116
21884979
12679336
11238951
12607003
9705271
17713585
10783165
12447395
10426999
18458108
15758953
|
SIRT1
|
NBN
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
17612497
|
NPM1
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
12.0
|
1.0
|
Omnipath
|
23443559
15144954
16740634
15310764
16376884
12080348
|
XRCC5
|
PAXIP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
22179609
11493912
9512523
11604075
12947387
|
UBE2V2
|
PAXIP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15468306
15574327
23333306
23306437
15723659
23727112
|
MRE11
|
PAXIP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15468306
15574327
23333306
23306437
15723659
23727112
|
RNF8
|
PAXIP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15468306
15574327
23333306
23306437
15723659
23727112
|
NSD2
|
PAXIP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15468306
15574327
23333306
23306437
15723659
23727112
|
XRCC6
|
PAXIP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
22179609
11493912
9512523
11604075
12947387
|
UBE2N
|
PAXIP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15468306
15574327
23333306
23306437
15723659
23727112
|
PAXIP1
|
PIAS4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15468306
15574327
23333306
23306437
15723659
23727112
|
PAXIP1
|
RNF168
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15468306
15574327
23333306
23306437
15723659
23727112
|
TP53BP1
|
PAXIP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
19414588
15456759
17690115
14576432
19481982
|
PAXIP1
|
TP53BP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
14576432
15456759
19481982
19414588
|
KDM4B
|
PIAS4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
19203579
22589545
22980979
18001825
19203578
18001824
18006705
|
KDM4A
|
PIAS4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
19203579
22589545
22980979
18001825
19203578
18001824
18006705
|
NRAS
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
31135801
24897931
8665852
17998941
11136978
21779505
8052307
12121613
1716764
26085527
21779497
12094235
|
KRAS
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
31135801
24897931
8665852
17998941
11136978
21779505
8052307
12121613
1716764
26085527
21779497
12094235
|
TP53
|
PIK3R1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
10321740
19763735
21057544
18661553
|
STAT3
|
PIK3R1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
11733515
24218138
23963458
15793565
16293640
|
HRAS
|
PIK3R1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
9069260
25241761
10212255
11313862
9150145
16713569
15021914
|
PIK3R1
|
PIK3CD
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
9113989
8596638
21827948
12147247
11733063
22020336
24165795
31031754
14665640
|
PRKDC
|
POLL
|
â—¼ PHYSICAL_INTERACTION
|
|
|
13.0
|
1.0
|
Reactome
|
16439204
17470781
22529269
15451442
14561766
12077346
10757784
9259561
16439205
11702069
18046455
9430729
12509254
|
LIG4
|
POLL
|
â—¼ PHYSICAL_INTERACTION
|
|
|
13.0
|
1.0
|
Reactome
|
16439204
17470781
22529269
15451442
14561766
12077346
10757784
9259561
16439205
11702069
18046455
9430729
12509254
|
XRCC4
|
POLL
|
â—¼ PHYSICAL_INTERACTION
|
|
|
13.0
|
1.0
|
Reactome
|
16439204
17470781
22529269
15451442
14561766
12077346
10757784
9259561
16439205
11702069
18046455
9430729
12509254
|
XRCC6
|
POLL
|
â—¼ PHYSICAL_INTERACTION
|
|
|
13.0
|
1.0
|
Reactome
|
16439204
17470781
22529269
15451442
14561766
12077346
10757784
9259561
16439205
11702069
18046455
9430729
12509254
|
XRCC5
|
POLL
|
â—¼ PHYSICAL_INTERACTION
|
|
|
13.0
|
1.0
|
Reactome
|
16439204
17470781
22529269
15451442
14561766
12077346
10757784
9259561
16439205
11702069
18046455
9430729
12509254
|
XRCC6
|
POLM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
13.0
|
1.0
|
Reactome
|
16439204
17470781
22529269
15451442
14561766
12077346
10757784
9259561
16439205
11702069
18046455
9430729
12509254
|
PRKDC
|
POLM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
13.0
|
1.0
|
Reactome
|
16439204
17470781
22529269
15451442
14561766
12077346
10757784
9259561
16439205
11702069
18046455
9430729
12509254
|
XRCC5
|
POLM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
13.0
|
1.0
|
Reactome
|
16439204
17470781
22529269
15451442
14561766
12077346
10757784
9259561
16439205
11702069
18046455
9430729
12509254
|
LIG4
|
POLM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
13.0
|
1.0
|
Reactome
|
16439204
17470781
22529269
15451442
14561766
12077346
10757784
9259561
16439205
11702069
18046455
9430729
12509254
|
XRCC4
|
POLM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
13.0
|
1.0
|
Reactome
|
16439204
17470781
22529269
15451442
14561766
12077346
10757784
9259561
16439205
11702069
18046455
9430729
12509254
|
PPP5C
|
PRKDC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
14734805
|
PRKDC
|
MAPK8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
11749722
16319174
|
PRKDC
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
79.0
|
1.0
|
Omnipath
|
15355354
19398950
15254178
9372954
11483158
7862459
16713569
11875057
11551930
11883897
12548019
25168287
8502477
11709713
10446957
28145533
22726545
24886358
16552184
12242661
17570479
10196661
10747897
9885574
10673501
12091386
22355272
9765199
15489221
9561848
10801407
22504299
22444248
15177184
11042698
10358069
10470151
10606744
9744860
16397295
12959929
12064478
27130668
10951572
12111733
25937999
15381073
28102346
9363941
19918261
|
PRKDC
|
LIG4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
9.0
|
1.0
|
Omnipath
|
15194694
15941674
17570479
|
RAD1
|
MCM5
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
31.0
|
1.0
|
ACSN
|
10884395
12086603
14726013
14988723
15136767
15175241
15459660
15703371
15798197
16697054
16713580
16805667
16885023
17102137
17116885
17296725
17303408
17384638
17493829
17582221
18469862
18995830
19282663
19342888
19622404
19793801
19847258
20051983
20478261
8943031
9524127
|
XRCC5
|
RAD50
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
22179609
11493912
9512523
11604075
12947387
|
XRCC6
|
RAD50
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
22179609
11493912
9512523
11604075
12947387
|
RAD50
|
BARD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
22021381
16153896
18923075
18805091
21325134
22792074
19419957
21052091
18971343
25122754
11301010
21240188
|
RAD50
|
MRE11
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
19197236
16163361
10888888
8756642
17713585
|
RAD50
|
RINT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
11096100
16600870
17470549
|
SIRT6
|
RBBP8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
20829486
|
XRCC6
|
RNF168
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
22179609
11493912
9512523
11604075
12947387
|
XRCC5
|
RNF168
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
22179609
11493912
9512523
11604075
12947387
|
KDM4B
|
RNF168
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
19203579
22589545
22980979
18001825
19203578
18001824
18006705
|
RNF8
|
KDM4B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
19203579
22589545
22980979
18001825
19203578
18001824
18006705
|
RNF8
|
XRCC6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
22179609
11493912
9512523
11604075
12947387
|
RNF8
|
TP53BP1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
ACSN
|
18001824
18006705
19203579
19772495
|
RNF8
|
UBE2N
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
20023648
21911360
22589545
25909880
16215985
24732096
18678647
26285145
23255131
22814251
19549727
|
MAPK8
|
SIRT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
20.0
|
1.0
|
Omnipath
|
29578371
17081983
19007248
23434668
21540183
22622703
17924679
18187866
24296261
18838864
19413330
20027304
21471201
19107194
16964243
18669648
15302935
|
SIRT1
|
XRCC6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
17334224
16189514
15205477
|
SIRT1
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
21.0
|
1.0
|
Omnipath
|
18235502
11672523
18235501
15205477
35931247
15989956
17964266
25280219
19047049
16713569
19960022
21245319
12006491
19590512
|
SIRT6
|
H3C2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
18337721
16439206
19408108
|
MAPK8
|
STAT3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
66.0
|
1.0
|
Omnipath
|
23255093
17502367
21702955
19413330
11335711
9343414
23331499
15465816
12576423
11350938
20068231
12763138
9872331
18491316
18669648
10521505
18691976
20058876
15979846
14551213
10446219
|
MAP2K2
|
STAT3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
17142955
9305919
7719937
7568001
10602027
12681450
7719938
7544001
7528668
|
E2F4
|
TOPBP1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
17531812
15195143
|
ETS1
|
TP53
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
12145208
19022222
8649821
10510472
|
TP53
|
HNF4A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
11818510
16895524
|
TP53
|
KRAS
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
11514734
18555006
10953306
14741382
19107228
20124454
8274455
16061648
10448271
|
TP53
|
CCNA2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
9.0
|
1.0
|
Omnipath
|
16931621
8270002
9275177
19671680
16571800
8641461
9360984
21952947
|
TP53
|
HRAS
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
21552926
9662334
11127813
21552928
|
TP53
|
CCNB1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
15.0
|
1.0
|
Omnipath
|
12874009
14627709
10051609
11313928
17942917
11892838
15710382
20395210
19470724
12379461
11071927
11522645
15737644
11162602
|
TP53
|
MAPK8
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
22607268
23376463
18374905
15958553
10854211
22353755
|
TP53
|
USP7
|
â—¼ CLEAVAGE
|
✅
|
|
4.0
|
1.0
|
Reactome
|
16402859
15053880
16474402
11923872
|
TP53BP1
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
40.0
|
1.0
|
Omnipath
|
25579814
12110597
25837623
16713569
14978302
22653443
26022179
27546791
8016121
12351827
15611139
15364958
14985081
19433796
17805299
25651062
11877378
17634560
22084066
20307547
|
PPP1CB
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
16501611
15178317
|
USP7
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
40.0
|
1.0
|
Omnipath
|
26460617
21845734
23382381
16713569
25283148
15916963
18375498
19918835
24462112
22056774
17268548
22653443
23388826
21170034
20816748
17525743
16402859
11923872
17380154
16082221
26238070
16845383
16474402
35538032
22084066
|
DAXX
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
12954772
21482821
21134643
16845383
25241761
15364927
16713569
12482984
15339933
23038753
|
AURKB
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
13.0
|
1.0
|
Omnipath
|
20959462
27933271
20847049
15469940
32873634
22611192
27496712
|
MAPK13
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
15187187
19436832
15140942
10581258
20506250
21614932
16393692
24818748
11274345
|
MAPK8
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
37.0
|
1.0
|
Omnipath
|
11108663
12531896
16713569
11283254
10706102
19651615
27147566
9724739
15538975
9732264
10581258
10436023
17570479
9393873
11896587
12514174
15580310
18813780
11078726
|
PPP1CC
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
17145710
17274640
15178317
16501611
|
CCNA2
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
14640983
10884347
16713569
|
XRCC5
|
TP53BP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
22179609
11493912
9512523
11604075
12947387
|
XRCC6
|
TP53BP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
22179609
11493912
9512523
11604075
12947387
|
UBE2N
|
TP53BP1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
10.0
|
1.0
|
ACSN
|
17349954
17652783
18196958
19203579
19258535
19793861
19793862
19841479
19851286
22771115
|
TP53BP1
|
BARD1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
7.0
|
1.0
|
ACSN
|
11042216
11877378
17243194
18087291
19342239
20646866
9748285
|
AURKB
|
TP53BP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
28415769
|
XRCC6
|
UBE2N
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
22179609
11493912
9512523
11604075
12947387
|
KDM4B
|
UBE2N
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
19203579
22589545
22980979
18001825
19203578
18001824
18006705
|
KDM4A
|
UBE2N
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
19203579
22589545
22980979
18001825
19203578
18001824
18006705
|
XRCC5
|
UBE2N
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
22179609
11493912
9512523
11604075
12947387
|
XRCC5
|
UBE2V2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
22179609
11493912
9512523
11604075
12947387
|
XRCC6
|
UBE2V2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
22179609
11493912
9512523
11604075
12947387
|
KDM4A
|
UBE2V2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
19203579
22589545
22980979
18001825
19203578
18001824
18006705
|
KDM4B
|
UBE2V2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
19203579
22589545
22980979
18001825
19203578
18001824
18006705
|
NSD2
|
XRCC5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
22179609
11493912
9512523
11604075
12947387
|
XRCC5
|
MRE11
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
22179609
11493912
9512523
11604075
12947387
|
NSD2
|
XRCC6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
22179609
11493912
9512523
11604075
12947387
|
XRCC6
|
MRE11
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
22179609
11493912
9512523
11604075
12947387
|
LIG4
|
XRCC4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
30.0
|
1.0
|
ACSN
|
11163244
12032095
12471202
15385968
15703371
16439205
16697054
17088286
17638872
18077224
19346677
19473888
19546231
196269035
19772495
19808869
19847258
20691907
21175350
21211721
21270334
21300785
21376743
22055391
22469522
22713970
22743550
23178593
24050180
9242410
|
LIG4
|
XRCC4
|
â—¼ SHARES_COMPLEX
|
|
|
30.0
|
1.0
|
ACSN
|
11163244
12032095
12471202
15385968
15703371
16439205
16697054
17088286
17638872
18077224
19346677
19473888
19546231
196269035
19772495
19808869
19847258
20691907
21175350
21211721
21270334
21300785
21376743
22055391
22469522
22713970
22743550
23178593
24050180
9242410
|
MRE11
|
BARD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
22021381
16153896
18923075
18805091
21325134
22792074
19419957
21052091
18971343
25122754
11301010
21240188
|
CDKN2B
|
CDK6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
26186194
26578655
23602568
25416956
32296183
|
CCND2
|
CDK6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
10477583
17517622
16713569
|
CDK6
|
RBL2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
10.0
|
1.0
|
Omnipath
|
10498883
10385618
9736735
11157749
12006580
|
GADD45G
|
MAP2K3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
11175814
21614932
12738796
11274345
12213961
18855897
|
E2F4
|
CCNB1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
17531812
15855772
22508987
|
E2F4
|
AURKB
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
17531812
15033491
|
E2F4
|
PPARG
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
15711575
15895078
12110166
|
E2F4
|
E2F2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
17531812
21247883
9149906
15718499
|
E2F4
|
CCNA2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
17531812
17121828
21311680
15448153
|
E2F4
|
MCM5
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
17531812
11799067
|
RBL2
|
E2F4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
19.0
|
1.0
|
Omnipath
|
22002537
16600870
17671431
9858615
15838517
9121766
11573202
20133863
8657117
17531812
17159899
9144196
12006580
23108140
|
PIK3R2
|
HRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
31135801
24897931
8665852
17998941
11136978
21779505
8052307
12121613
1716764
26085527
21779497
12094235
|
HRAS
|
MAP2K2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
HRAS
|
PIK3CD
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
9069260
9113989
9235916
21779497
11739523
10545207
|
HRAS
|
MAPK8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
11525649
8137421
16810318
16713569
|
TINF2
|
POT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
14.0
|
1.0
|
ACSN
|
10581025
10850490
11349150
15231715
16166375
18680434
18828880
19454690
19965504
22064479
22634377
7502076
9326951
9822378
|
TINF2
|
TERF2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
14.0
|
1.0
|
ACSN
|
10581025
10850490
11349150
15231715
16166375
18680434
18828880
19454690
19965504
22064479
22634377
7502076
9326951
9822378
|
TINF2
|
POT1
|
â—¼ SHARES_COMPLEX
|
|
|
14.0
|
1.0
|
ACSN
|
10581025
10850490
11349150
15231715
16166375
18680434
18828880
19454690
19965504
22064479
22634377
7502076
9326951
9822378
|
TINF2
|
TERF2
|
â—¼ SHARES_COMPLEX
|
|
|
14.0
|
1.0
|
ACSN
|
10581025
10850490
11349150
15231715
16166375
18680434
18828880
19454690
19965504
22064479
22634377
7502076
9326951
9822378
|
ACD
|
TINF2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
25910212
16880378
15181449
25416956
21044950
15383534
31515488
26496610
16713569
15231715
|
POT1
|
TERF2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
14.0
|
1.0
|
ACSN
|
10581025
10850490
11349150
15231715
16166375
18680434
18828880
19454690
19965504
22064479
22634377
7502076
9326951
9822378
|
POT1
|
TERF2
|
â—¼ SHARES_COMPLEX
|
|
|
14.0
|
1.0
|
ACSN
|
10581025
10850490
11349150
15231715
16166375
18680434
18828880
19454690
19965504
22064479
22634377
7502076
9326951
9822378
|
TERF2
|
TERF2IP
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
32.0
|
1.0
|
Omnipath
|
17145710
19651898
15316005
27214791
10888888
21217703
19287395
15383534
26496610
23086976
19164295
15100233
16880378
26450775
21829167
10850490
28082411
23307557
21044950
14565979
|
AURKB
|
H3C2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
33.0
|
1.0
|
Omnipath
|
11278789
19007248
17938195
10464286
16457588
12234980
12082625
21282660
15249581
10949293
15108802
16185088
14583461
12588998
15681610
17924679
16222246
15684425
12560483
11856369
|
AURKB
|
HDAC5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
22865920
|
GATA3
|
PPARG
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
18522800
15632071
15896659
|
MAPK8
|
PPARG
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
9030579
|
GADD45B
|
MAP2K3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
11175814
21614932
12738796
11274345
12213961
18855897
|
CCND2
|
RBL2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
10385618
9736735
12006580
10498883
|
LMNA
|
CCNB1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
22986494
2188731
2344612
2188730
|
E2F2
|
CCNB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
15510213
18319725
|
E2F3
|
CCNB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
15510213
18319725
|
E2F3
|
CCNA2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
15510213
11980909
10733529
18319725
|
HSF2
|
HSPA4
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
8035809
20937767
9738016
1508207
8114740
12813038
|
KRAS
|
MAP2K2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
MAPK8
|
NFATC3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
14517246
16648474
10978313
23047924
9374467
9630228
11274345
|
MAP2K3
|
MAPK13
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
23331499
11242034
21614932
12738796
11274345
9374491
18083107
9790884
18855897
|
PIK3R2
|
KRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
31135801
24897931
8665852
17998941
11136978
21779505
8052307
12121613
1716764
26085527
21779497
12094235
|
PPP3CA
|
NFATC3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
8576111
8631904
10860980
9727000
8799126
|
PPP3CA
|
NFATC3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
10860980
21880741
12594826
11509611
16407284
|
PIK3R2
|
NRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
31135801
24897931
8665852
17998941
11136978
21779505
8052307
12121613
1716764
26085527
21779497
12094235
|
RBL2
|
E2F5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
16600870
17531812
11756542
7760804
15838517
|
GATA3
|
H3C2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
14.0
|
1.0
|
Reactome
|
18533032
27062924
21151129
16009131
16087863
16980581
21934649
16113099
18358809
22056668
23172872
15282324
21878914
23192763
|
KDM4B
|
H3C2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
23435229
21445275
20682797
23723241
|