Protein list:

Seperate proteins by space | Example

Select nodes using shift click or drag to add to this list
Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
Graph tools:

Note this may take some time with > 30 proteins
Filter Graph:

0.5
Layout:
  🔂

Click a node or edge for more data...
Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
CHEK2 ATM â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 19001859 12364621
MDM2 ATM â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 19816404 21986495
CHEK2 ATM â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 16651405 10724175
ATM CCAR2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 22465953 22735644
BRCA1 ATR â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12791985 16327781
ATRIP ATR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0706013104 17686975
ATR BARD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12791985 16327781
TP53 ATR â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 9925639 10435622
ATR CCAR2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 22465953 22735644
ATR BRCA1 â—¼   PHOSPHORYLATION ✅ + 0.8 0.8 Signor 23422745
BRCA1 ATRIP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12791985 16327781
ATRIP BARD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12791985 16327781
TP53 ATRIP â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 9925639 10435622
MYBL2 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15606792 10344757
DDIT3 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15836916 20398749
ETS1 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17590421 10698492
NOTCH1 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9881968 16990763
DDIT3 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17652152
HSP90AA1 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18266962
STAT3 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11994401
EP300 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23353771 23285190
SMAD3 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19768112 15735739
POLR2K BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10725406 16713569
JMJD6 BRD4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 23455924 8417751
TP53 CCAR2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20160719 20074560
CSNK2A1 CCAR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24962073
CCND1 AR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16461912 0506281103
NCOA2 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21505052 22581837
STAT3 CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11279133
CCND1 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11279133
SUPT5H CCNK â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
CCNK CTDP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
CCNK NCBP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
CCNK NELFE â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
CCNK NELFB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
CCNK NELFA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
CCNK NELFCD â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
CCNK SUPT4H1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
CCNK NCBP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
TP53 CCNK â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11988847
TP53 CCNK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
GTF2F2 CDK9 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17690249 22492511
GTF2F1 CDK9 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17690249 22492511
NELFE CDK9 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
CLSPN CDK9 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20930849 8057995
CDK9 NELFA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
CDK9 NELFCD â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
CDK9 NCBP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
CDK9 NELFB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
CDK9 SUPT4H1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
CDK9 NCBP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
PPP1CC CDK9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21533037
CHEK2 MDM2 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 15862297 5217705
DDIT3 CCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18649942 15829559
DDX5 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18829551
ESR1 EP300 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16704985 11279135
EP300 RELA â—¼   ACETYLATION ✅ 2.0 0.8 intact 5214468 11533489
EP300 CCNT1 â—¼   ACETYLATION ✅ 2.0 0.8 intact 7265510 19387490
MAPK3 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24530506
EP300 DDX17 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20663877
EP300 H3C14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11509556
POLR2C ERCC3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0804424105 18562274
AR ERCC3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12593864 12648523
AR FKBP5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15131019
HSP90AA1 TRAF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSP90AA1 AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12799359 11988487
HSP90AA1 AR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0908908106 19805354
CEBPB HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9880553 10440232
CEBPB HSP90AA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18266962
PRKACA IMMT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 27153535
MAPK3 SQSTM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7717053 20154642
TP53 MAPK3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21187340 16050810
MAPK3 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16888388 16691505
MAPK3 METTL3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 33217317
ETS1 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11424091
DDX17 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17226766
PPP1CC MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23277204
MDM2 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21988832 23839035
TP53 MSH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12209975
CCNT2 NELFA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
POLR2C NELFA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0804424105 18562274
SUPT5H NELFA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10916156 12676794
SUPT4H1 NELFA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10916156 12676794
CCNT1 NELFA â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
NELFA CTDP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10916156 12676794
PTBP1 NPM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218180 16376875
NPM1 KMT2A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
ESR1 PRKCD â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22430216 18414489
PRKACA PSMD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SNW1 SMAD3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5213835 11278756
HSPA1A SQSTM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ETS1 SQSTM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9762895
RELA STAT3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 25040843
STAT3 IL1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17386941 31886314
STAT3 IL6ST â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9169475
SUPT5H NELFCD â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10916156 12676794
SUPT5H CCNT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
SUPT5H NELFB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10916156 12676794
SUPT5H NELFE â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10916156 12676794
SUPT5H CCNT2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
TAF7 CCNT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0801637105 18391197
JMJD6 TP53 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 24667498 1001819
STIP1 TP53 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
AR TP53 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19481544 7103716
TP53 NCL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22103682 8291914
TP53 CSNK2B â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12393879 11239457
TP53 CSNK2A1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12393879 11239457
TP53 SMAD3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21900401
TP53 TWIST1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18504427 20689556
TP53 MAML1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24473123 17317671
RCHY1 TP53 â—¼   COLOCALIZATION 2.0 0.8 intact 5220017 17568776
JMJD6 TP53 â—¼   HYDROXYLATION ✅ 2.0 0.8 intact 24667498 1001819
TP53 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10766163 16713569
TP53 BARD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14636569 15782130
TRIM33 TRIM28 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1101544108 21531907
TWIST1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22056872 22457607
UBR5 SMAD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
ETS1 CCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22869003 20428211
ESR1 CCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20404154 17932106
ETS1 CSNK2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11389726
CSNK2A1 CSNK2B â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
CCNT1 NCBP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
NELFE NCBP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10916156 12676794
CCNT2 NCBP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
RNF40 NCBP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
NCBP1 NELFCD â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10916156 12676794
NCBP2 NCBP1 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
CSNK2A1 CDC34 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5214488 11546811
ESR1 HEXIM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18757415 21423213
ESR1 PTPN6 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 intact 6673088 7539106
RMND5B SMAD4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
NELFCD SMAD4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD4 CEBPB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12202226 5215691
HSP90AB1 TRAF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
PPM1A SMAD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16751101 8277589
SMAD2 MED24 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12167862 5215637
PPM1A SMAD3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16751101 8277589
PRKACA SMAD3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
AR SMAD3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20739403 20610535
ESR1 MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10935492 12878732
ELK1 MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19554388 18240315
AR NOTCH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22347519 23145211
AR NCOR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19351840 20610535
ESR1 HES1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18414489 19039095
HES1 MAML1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22529374 21640102
SKP1 HSP90AB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7304783 18818696
SKP2 SKP1 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
ESR1 PPARGC1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16704985 18511507
CSNK2A1 RELA â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5212888 10938077
GSK3A RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22761446
MAML1 CDK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15546612
PRKACA AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
MED28 HCK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7033846 16964398
HCK NCL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12029088 5215418
AR SMAD1 â—¼   COLOCALIZATION 2.0 0.8 intact 5219486 17183365
ANXA2 PTK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
NCOA2 PRKACA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11923473 23936147
CCNT1 GTF2F2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17690249 22492511
CCNT1 NELFB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
CCNT1 NELFCD â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
CCNT1 CTDP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
CCNT1 NCBP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
CCNT1 SUPT4H1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
CCNT1 NELFE â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
KMT2A MLLT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7900984 18952892
HSP90AB1 AR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 21730179 1105160108
HSP90AB1 AIP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19375531 7021854
AIP ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21984905
NCOA2 AR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12588987 5216126
MYBL2 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18945670 17975021
AR RCHY1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20610535 16914734
AR MBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20610535 7657701
AR PGC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17721441
NELFE NCBP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10916156 12676794
CCNT2 NCBP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
GTF2F2 POLR2E â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11278533
POLR2C GTF2F2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0804424105 18562274
ANXA2 HMGN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
POLR2C GTF2F1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0804424105 18562274
NELFE CTDP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10916156 12676794
POLR2A CTDP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216783 14576432
CCNT2 CTDP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
NELFB CTDP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10916156 12676794
NELFCD CTDP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10916156 12676794
POLR2B CTDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15670829
POLR2C MED17 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0804424105 18562274
POLR2C NELFCD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0804424105 18562274
POLR2C NELFB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0804424105 18562274
POLR2C POLR2A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0804424105 18562274
POLR2C NELFE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0804424105 18562274
POLR2C POLR2B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0804424105 18562274
MYBL2 HSPA1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8545114 9121772
SUPT4H1 NELFB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10916156 12676794
CCNT2 NELFB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
CCNT2 NELFE â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
NELFE SUPT4H1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10916156 12676794
CCNT2 SUPT4H1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
SUPT4H1 NELFCD â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10916156 12676794
EAF1 ELL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16006523 11418481
CCNT2 NELFCD â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10866664 7853496
CCNH POLR2C â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
CCNH POLR2J â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
CDK7 GTF2F2 â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
CDC73 SUPT4H1 â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
POLR2I SUPT6H â—¼   PHYSICAL_INTERACTION 804.0 0.8 STRING 36370105
AFF1 ELL3 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
ATM CHEK2 â—¼   PHOSPHORYLATION ✅ + 0.8 0.8 Signor 10973490
CTDP1 POLR2G â—¼   PHYSICAL_INTERACTION 807.0 0.8 STRING 36370105
CCNH TCEA1 â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
ESR1 BRCA1 â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 1204073 5215931 11244506
BRCA1 SMAD3 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 19768112 15735739
BRD4 EP300 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 32416067 20676058 24945803 30428346
SMAD1 DDX5 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 18548003
DDX17 EP300 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 17226766 19995069 33742100 20663877
AKT1 MDM2 â—¼   PHOSPHORYLATION ✅ 0.81 0.81 mint 5217292 15527798
MDM2 AKT1 â—¼   PHOSPHORYLATION ✅ 0.81 0.81 mint 5217292 15527798
TP53 UBE2A â—¼   PHYSICAL_INTERACTION 811.0 0.81 STRING 36370105
MED12 MED24 â—¼   PHYSICAL_INTERACTION 812.0 0.81 STRING 36370105
CDK7 POLR2D â—¼   PHYSICAL_INTERACTION 813.0 0.81 STRING 36370105
POLR2J SUPT6H â—¼   PHYSICAL_INTERACTION 813.0 0.81 STRING 36370105
CDK7 POLR2C â—¼   PHYSICAL_INTERACTION 814.0 0.81 STRING 36370105
MED14 POLR2L â—¼   PHYSICAL_INTERACTION 814.0 0.81 STRING 36370105
MED14 POLR2K â—¼   PHYSICAL_INTERACTION 814.0 0.81 STRING 36370105
MED14 POLR2H â—¼   PHYSICAL_INTERACTION 814.0 0.81 STRING 36370105
MED14 POLR2I â—¼   PHYSICAL_INTERACTION 814.0 0.81 STRING 36370105
CDC73 RNF20 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HuRI 32296183
CDC73 SUPT6H â—¼   PHYSICAL_INTERACTION 815.0 0.81 STRING 36370105
PAF1 POLR2D â—¼   PHYSICAL_INTERACTION 815.0 0.81 STRING 36370105
PAF1 SUPT4H1 â—¼   PHYSICAL_INTERACTION 815.0 0.81 STRING 36370105
CDC73 POLR2E â—¼   PHYSICAL_INTERACTION 816.0 0.81 STRING 36370105
HSP90AB1 HSPA1A â—¼   PHYSICAL_INTERACTION 816.0 0.81 STRING 36370105
CDC73 POLR2L â—¼   PHYSICAL_INTERACTION 817.0 0.81 STRING 36370105
CCNH POLR2I â—¼   PHYSICAL_INTERACTION 818.0 0.81 STRING 36370105
CDC73 BRD4 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 26659056 32416067
BRD4 LARP7 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 26659056 32416067
BRD4 MED12 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 32416067 16109376
CDK9 EAF1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 23455922 21729782
CDK9 DDX21 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 26209609 25470060
CDK9 ANXA2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 9184228 26209609
CDK9 ELL â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 32152128 21729782
CDK9 CDK12 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 23455922 23602568
PSMD2 MDM2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 20479273 18086887
ESR1 PSMD2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 19805454 25604459
ESR1 SNW1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 19934264 33731348
SNW1 CCNT1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 20467437 19818711
CDK15 STAT3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
CDC73 POLR2K â—¼   PHYSICAL_INTERACTION 819.0 0.82 STRING 36370105
CDC73 POLR2I â—¼   PHYSICAL_INTERACTION 819.0 0.82 STRING 36370105
CDC73 POLR2F â—¼   PHYSICAL_INTERACTION 819.0 0.82 STRING 36370105
SKP2 CUL1 â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 6540196 18239684
SKP1 ESR1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31527615 23770852
SKP2 AKT1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 19270695 21358672 23911321 19270694
AFF1 CCNT1 â—¼   PHYSICAL_INTERACTION 819.0 0.82 STRING 36370105
PAF1 POLR2B â—¼   PHYSICAL_INTERACTION 819.0 0.82 STRING 36370105
MED26 AFF4 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 15175163 21729782
MED26 ELL2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 15175163 21729782
CCND1 CDKN1C â—¼   PHYSICAL_INTERACTION 820.0 0.82 STRING 36370105
AKT1 HSP90AB1 â—¼   PHYSICAL_INTERACTION 820.0 0.82 STRING 36370105
HIST1H3A TRIM33 â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
POLR2H POLR2J â—¼   PHYSICAL_INTERACTION 822.0 0.82 STRING 36370105
PAF1 POLR2I â—¼   PHYSICAL_INTERACTION 822.0 0.82 STRING 36370105
POLR2B SUPT6H â—¼   PHYSICAL_INTERACTION 822.0 0.82 STRING 36370105
ACTL6A HIST1H4A â—¼   PHYSICAL_INTERACTION 825.0 0.82 STRING 36370105
CDC73 POLR2D â—¼   PHYSICAL_INTERACTION 825.0 0.82 STRING 36370105
FBXL19 SKP1 â—¼   PHYSICAL_INTERACTION 825.0 0.82 STRING 36370105
HIST1H3A NPM1 â—¼   PHYSICAL_INTERACTION 826.0 0.82 STRING 36370105
HIST1H4A KMT2A â—¼   PHYSICAL_INTERACTION 827.0 0.82 STRING 36370105
AFF4 EAF1 â—¼   PHYSICAL_INTERACTION 827.0 0.82 STRING 36370105
HIST1H3A MLLT1 â—¼   PHYSICAL_INTERACTION 828.0 0.82 STRING 36370105
PAF1 SUPT6H â—¼   PHYSICAL_INTERACTION 828.0 0.82 STRING 36370105
BRCA1 TERF1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 34112789 19797051 29656893
BRCA1 TERF2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 34112789 25184681 19797051 29656893
BRCA1 CDK9 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 22990118 28278048
BRD4 MED1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 19766566 33567268 31239290 20098423 30554943 32416067
BRD4 MED17 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 30554943 32416067 16109376
BRD4 MED14 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 30554943 33567268 32416067 16109376
BRD4 MED24 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 30554943 32416067 16109376
CDK7 FKBP5 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
ELL2 CDK9 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 27684187 21873227 32479599 21729782 22483617
SNW1 CDK9 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 20467437 19818711 26209609
CDK9 IMMT â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 27684187 9184228 26209609
CDK9 DDX5 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 17643375 26209609
CDK9 CUL1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 11689688 12861003
CDK9 GRN â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 32814053 12588988
LARP7 DDX21 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 26725010 29845934 33961781 25470060
AFF4 ELL3 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
ELL3 ELL â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
ELL3 AFF1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
ELL3 CCNT1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
ELL3 CCNT2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
PPP5C HSP90AA1 â—¼   PHYSICAL_INTERACTION ✅ 0.83 0.83 mint 27880917
ESR1 IMMT â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 33731348 19805454 31527615
BARD1 LARP7 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 22990118 32726637
SMAD3 MEN1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 11274402 16189514
NELFCD NELFA â—¼   PHYSICAL_INTERACTION ✅ 0.83 0.83 mint 24981860
CDK8 CTDP1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 19914168 26496610
MED28 MED14 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 15175163 33961781 20133760 24981860
MED14 MED17 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 9989412 18418385 33961781 24981860 22939629 26344197
MED17 MED24 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 22939629 33961781 26344197 24981860
EAF1 AFF4 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 26186194 33961781 21729782
AFF4 ELL â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 26186194 33961781 21729782
AFF4 CCNT2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 26186194 33961781 21729782
ELL2 AFF1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 26496610 21729782 24367103
EAF1 AFF1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 26186194 33961781 21729782
MED28 MED24 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 15175163 33961781 20133760 24981860
PPM1A PPM1B â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
TULP3 JMJD6 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33187986 33961781
CENPA NPM1 â—¼   PHYSICAL_INTERACTION 830.0 0.83 STRING 36370105
GTF2F2 POLR2H â—¼   PHYSICAL_INTERACTION 832.0 0.83 STRING 36370105
AIP HSP90AA1 â—¼   PHYSICAL_INTERACTION 834.0 0.83 STRING 36370105
AKT1 BRCA1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
CCND1 EP300 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
MDM2 NPM1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
MDM2 NCL â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
NOTCH1 SNW1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
RELA STAT3 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
ESR1 TP53 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
ESR1 NCOA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 0.83 0.83 Signor 11477071
AR RCHY1 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
ATR CHEK2 â—¼   PHOSPHORYLATION ✅ + 0.83 0.83 Signor 10973490
CCND1 CUL1 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
DOT1L MLLT1 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
CDK9 TP53 â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
CDK9 SKP2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 11689688 12861003
SNW1 MSH2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 20467437 12840015
AKT1 MSH2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 28628118 24412244 28205554
SNW1 UBR5 â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
SNW1 NCOR1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 20467437 14985122
SMAD4 SKP2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 16865698 15314162
SMAD1 SMAD3 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 9111321 15761153 18729074
AKT1 SKP2 â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
ESR1 MED17 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 21182203 11867769
NCBP2 NELFE â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 26382858 26496610
TCEA1 PAF1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 20178742 21596312
AR CCND1 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
DDX5 ESR1 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
CDK8 MED26 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
CENPA HIST1H4A â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
NELFB NELFCD â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
DOT1L HIST1H4A â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
CDC73 POLR2C â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
CDC73 POLR2J â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
HIST1H3A HIST1H4A â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
HIST1H4A HIST2H2BE â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
HIST1H3A HIST2H2BE â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
NCBP1 RNF40 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HuRI 32296183
CCNH POLR2B â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
CDC7 CHEK2 â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
NELFB SUPT5H â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
PAF1 POLR2F â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
NELFB POLR2C â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
NELFE POLR2C â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
NELFB POLR2A â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
BARD1 TP53 â—¼   PHYSICAL_INTERACTION 848.0 0.84 STRING 36370105
POLR2D SUPT6H â—¼   PHYSICAL_INTERACTION 848.0 0.84 STRING 36370105
CCND1 STAT3 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 11279133 15659654
CDK9 CCNT2 â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 24981860
EP300 SMAD1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 10205054 20851880 22365546 16613856 10673036
TCEA1 UBR5 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 21127351 17643375
SMAD2 ESR1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 20207742 11555647
SMAD3 CEBPB â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 12202226 12524424
MED12 CDK19 â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 30099503
BTK HCK â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 32707033 8058772
CEBPB ESR1 â—¼   PHYSICAL_INTERACTION 849.0 0.85 STRING 36370105
CLK3 JMJD6 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 28514442 32707033 33961781
CTDP1 POLR2E â—¼   PHYSICAL_INTERACTION 851.0 0.85 STRING 36370105
FKBP5 HSP90AB1 â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
MED12 MED17 â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
CEBPB EP300 â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
CTDP1 POLR2J â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
MED26 POLR2D â—¼   PHYSICAL_INTERACTION 857.0 0.85 STRING 36370105
BRCA1 CLSPN â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16713569 15096610 22863316
ESR1 CCNH â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 12527756 31527615
CDK7 POLR2B â—¼   PHYSICAL_INTERACTION 859.0 0.86 STRING 36370105
CDK9 CDC73 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 26659056 17643375
EP300 HIST2H2BE â—¼   PHYSICAL_INTERACTION 859.0 0.86 STRING 36370105
SMAD4 EP300 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 9679056 25514493 18215124 9843571 14612423 10887155 22033265
EP300 NCOA2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 10490106 9920895 15731352 20448036
EP300 STAT3 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 10205054 15653507 16713569 33531691 26504087 18782771 30110629 11923478 15735682 15649887 33742100 22116549
EP300 SMAD3 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 9679056 15824515 15688032 16109717 15345715 20564330 9843571 15133024 10497242 17469184 15623506 10575014 15588252 18055455 16876108 21567395 11134049 12743039 11058129
MDM2 CUL1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 20708156 24804778
ESR1 MEN1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16651450 31527615
ESR1 STAT3 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 23874500 11429412
CDC73 POLR2G â—¼   PHYSICAL_INTERACTION 859.0 0.86 STRING 36370105
AKT1 SMAD2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16362038 24412244
ESR1 CCNT1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 15940264 31527615
CDK19 MED28 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 28514442 15175163 33961781 24981860 26186194 23602568 20133760
AFF4 AFF1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 20153263 21729782
PAF1 POLR2C â—¼   PHYSICAL_INTERACTION 861.0 0.86 STRING 36370105
BRCA1 MSH2 â—¼   PHYSICAL_INTERACTION 862.0 0.86 STRING 36370105
BRD4 EP300 â—¼   PHYSICAL_INTERACTION 862.0 0.86 STRING 36370105
CTDP1 POLR2F â—¼   PHYSICAL_INTERACTION 862.0 0.86 STRING 36370105
CDK12 POLR2A â—¼   PHYSICAL_INTERACTION 864.0 0.86 STRING 36370105
SUPT16H SUPT4H1 â—¼   PHYSICAL_INTERACTION 866.0 0.86 STRING 36370105
CDC34 SKP2 â—¼   PHYSICAL_INTERACTION 866.0 0.86 STRING 36370105
CCND1 ESR1 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
MSH2 SNW1 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
HIST1H4A SUPT16H â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
NCBP1 RNF20 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HuRI 32296183
BRD4 CCNT2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 24360279 32416067 16109376
TCEA1 CDK7 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 26186194 9305922
CDK9 PAF1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 26659056 24837678 21873227
EAF1 ELL3 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 32296183 33961781 26186194 21729782
AKT1 EP300 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 21901101 15224190 21775285 20333651 18182168 11116148
ESR1 FKBP5 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 27483141 9222609
CDK15 FKBP5 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 25036637 33961781 26186194 23602568
LARP7 CCNT1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 18281698 26725010 33961781 27684187 18483487 24367103 29845934
MDM2 UBE2A â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 22083959 12640129
PPP5C HSP90AB1 â—¼   PHYSICAL_INTERACTION ✅ 0.87 0.87 mint 27880917
HEXIM1 CCNT1 â—¼   PHYSICAL_INTERACTION ✅ 0.87 0.87 mint 6613869 18483487
MED12 MED17 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 26496610 33961781 24981860 20133760 26344197
MED12 MED14 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 18418385 26496610 23563140 33961781 24981860 27684187 20133760 26344197
MED12 MED24 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 26496610 33961781 24981860 22939629 20133760
MED14 POLR2F â—¼   PHYSICAL_INTERACTION 869.0 0.87 STRING 36370105
CDK19 MED14 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 15175163 33961781 24981860 26186194 23602568 32707033
MED26 MED14 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 15175163 24981860 9989412 21729782
MED14 MED24 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 9989412 18418385 24882805 33961781 24981860 22939629 26344197
MED26 MED17 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 15175163 33961781 21729782 24981860
CDK19 MED17 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 15175163 33961781 24981860 23749998 26186194 23602568 32707033
MED26 CDK19 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 15175163 24981860 21729782 23746844
NELFE NELFB â—¼   PHYSICAL_INTERACTION ✅ 0.87 0.87 mint 24981860
ELL2 AFF4 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 32296183 26496610 33961781 26186194 21729782 22483617
MED26 MED24 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 15175163 33961781 24981860
MED28 MED26 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 15175163 33961781 24981860 21729782 20133760
CDK9 MLLT3 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
CHEK2 TP53 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
DDX17 DDX5 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
HEXIM1 LARP7 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
CDK8 MED28 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
AKT1 AR â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
CDK19 MED28 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
CDK19 MED24 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
HSP90AA1 HSPA1A â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
CSNK2A1 TP53 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
CDK19 CDK8 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
AFF1 MLLT3 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
ATR TP53 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
EP300 STAT3 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
ERCC3 TCEA1 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
AFF4 MLLT1 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
AFF1 MLLT1 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
AFF1 CDK9 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
MED26 POLR2E â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
AFF4 CCNT2 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
EP300 MDM2 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
SMAD4 TRIM33 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
CDK19 MED17 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
AFF4 MLLT3 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
EAF1 ELL2 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
ATM BRCA1 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
ATR BRCA1 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
CDK7 TCEA1 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
NPM1 TP53 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
MED1 MED28 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
ELL ELL3 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
CCNT1 LARP7 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
PTK2 TP53 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
SMAD2 TP53 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
SMAD2 TRIM33 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
SMAD3 TRIM33 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
BRCA1 CHEK2 â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
BRCA1 MED17 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 12154023 11504724 15208681
BRCA1 NCOA2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 14578343 11085509 16860316
BRD4 CCNT1 â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
EP300 CCND1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 15951563 10567390 11788592
CDK9 CCNK â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10574912 11884399
CDK7 ESR1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 15461668 10949034 31527615
CDK9 MLLT1 â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
CDK9 AFF3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 33961781 26186194 23602568 32707033 23455922
CDK9 AIP â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 33961781 26186194 32707033 23455922
SKP2 EP300 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 22770219 18243116 26593157
EP300 SMAD2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 11371641 21988832 10199400 12237408 11264182 15623506
CLK3 FKBP5 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 32707033 33961781 23602568
BCL10 TRAF2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 32296183 25416956 16713569 10753917 25910212 33961781 11466612
SMAD2 SMAD1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 9111321 28628118 18729074 28205554
EAF1 ELL â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 11418481 33961781 26186194 21729782 32152128
MED1 MED17 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
ATR ATRIP â—¼   PHOSPHORYLATION ✅ + 0.88 0.88 Signor 15451423
CDK9 LARP7 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
AR EP300 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
CDC73 POLR2B â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
MED14 POLR2G â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
HSPA1A STIP1 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
MED14 MED24 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
AFF4 ELL2 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
ELK1 MAPK3 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
MED1 MED24 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
EP300 SMAD4 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
ESR1 MED1 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
AFF4 ELL â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
BCL2 TP53 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
NCL NPM1 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
SUPT16H SUPT6H â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
AKT1 EP300 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
AR HSP90AA1 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
ELL3 MLLT3 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
MED1 MED12 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
ESR1 HSP90AA1 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
RCHY1 TP53 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
MED12 MED14 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
PAF1 POLR2G â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
MED17 MED24 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
BRCA1 ATRIP â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17616665 24073851 29656893
CCND1 BRCA1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17334399 16713569 9244350
MED1 BRCA1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 15208681 16713569
CCNK CDK12 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 26659056 32804079 26344197 22939629 26748711
AFF1 CDK9 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 32707033 32479599 20153263 33961781 21729782 21030982 23602568 26186194 27684187 23455922 24367103
CDK9 FKBP5 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 25036637 17643375 33961781 24981860 26186194 23602568 32707033 23455922 28363942
SNW1 DDX5 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 20467437 22939629 26344197
SMAD3 DDX5 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 15464984 18548003 19917253
HSP90AA1 HSP90AB1 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
MDM2 ESR1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 12897156 11178989 16713569 10766163 17545634 31012223
SMAD3 SNW1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11278756 18729074
SNW1 SMAD2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11278756 18729074
HIST1H3A SUPT16H â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
TP53 RCHY1 â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 17568776 5220017
TP53 RCHY1 â—¼   COLOCALIZATION ✅ 0.89 0.89 mint 17568776 5220017
CCNT2 HEXIM1 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
SMAD4 CEBPB â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 12202226 16959612 12524424
MED28 MED12 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 15175163 15989967 33961781 24981860 20133760
MED26 MED12 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 15175163 24981860 21729782 23563140
HIST1H3A KMT2A â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
AFF4 CCNT1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 20153263 33961781 12065898 26186194 21729782 27684187
AFF1 CCNT1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 20153263 21030982 27684187 19956800 24367103
CCNT1 GRN â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 12588988 16713569
MED26 MED1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 15175163 20098423 33961781 24981860 21729782
CDK19 MED1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 15175163 33961781 24981860 26186194 23602568 32707033 22939629 20133760
MED17 MED28 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
CDK19 MED24 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 15175163 33961781 24981860 26186194 23602568 32707033 26344197
EAF1 ELL2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 32296183 11418481 33961781 26186194 21729782
ATM CHEK2 â—¼   PHYSICAL_INTERACTION 891.0 0.89 STRING 36370105
GTF2F2 TCEA1 â—¼   PHYSICAL_INTERACTION 891.0 0.89 STRING 36370105
MED1 MED26 â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
BRD4 CDK9 â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
NELFA POLR2B â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
CDK8 MED17 â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
MED14 POLR2E â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
MED14 MED17 â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
POLR2C SUPT6H â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
DOT1L MLLT3 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
MED1 MED14 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
CDK19 MED1 â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
TERF1 ATM â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 18160036 11375976 15314656
ATM BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11114888 11278964 29656893 10783165 11016625 10866324 10550055 15713674 18344987 10608806 17478428
TP53 ATM â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 9843217 9733515 9733514
ATM METTL3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 32615088 17525332
ATM AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15546863 15899889
ATM RNF40 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21763684 26184323 17478428
ATRIP ATR â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19097996 28514442 19889979 17384638 15758953 14724280 15451423 23144622 26854234 21285353 18344416 20847938 20616048 15743907 14657349 11721054 15538388 17686975 18162465 17526493 33961781 15210935 18283122
ATR BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11114888 11278964 23901102 29656893 16713569 11016625 10608806 17478428
CEBPB BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12970736 19717648 17043638
PPP1CC BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17145710 17274640 12051739
ESR1 BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19887647 1244506 11782371 15674350 29367421 27977889 17392432 16860316 10334989 16260778 11244506 16061635 12400015 17505062 20060929 25499220 16713569 31527615 11493692
EP300 BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21102443 19887647 10655477 11782371 16713569 21212407 22787115
NELFB BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12612062 11739404 16713569
AKT1 BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21242970 10542266 20085797 19074868
BRCA1 MSH2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11498787 16713569 10783165 15886699 16260778
BRD4 CCNT1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 18039861 33567268 16109376 31753913 31239290 16109377 24360279 17690245 32416067 30554943 24367103 21555454
BRD4 JMJD6 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 33567268 33961781 29176719 24360279 32416067 30554943 23455924 21555454
BRD4 CDK9 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 18039861 19766566 26659056 21555454 24367103 17643375 31753913 31239290 16109377 32669118 24360279 17690245 32416067 30554943 16980611 16109376
BRD4 POLR2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22509028
ESR1 CCAR2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21596782 20074560 17473282
CCND1 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16061635 9039267 11073968
CEBPB CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22242598 11162569 12810706
ETS1 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19499154 15579511
CCNH ERCC3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 16189514 33707221 17643375 15220921 33453189 8692842 33961781 26186194 19934020 9118947 26340423 10734143
CDK7 ERCC3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 8692841 17643375 15220921 8521393 33453189 33961781 10082552 9130708 23602568 28977422 32707033 29568061 26340423
AFF4 CDK9 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 32707033 21873227 27684187 32479599 20153263 17643375 33961781 12065898 21729782 26186194 23602568 22483617 23455922
CDK9 LARP7 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 26659056 32707033 17643375 20562857 18281698 26725010 33961781 26186194 23602568 27684187 23455922 18483487 24367103 29845934
PPM1A CDK9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18829461
PPM1B CDK9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18829461
CDK9 RCHY1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 23603988
CHEK2 TERF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 26799419 19375317
CEBPB DDIT3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12706815 20562859 33961781 20102225 1547942 8662954
DDX5 EP300 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 20663877 19995069 33742100 12527917
DDX5 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 20663877 19995069 25604459 12738788 20308691 11250900 21182205 10409727
EP300 DDX5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12527917 20663877
MAML1 EP300 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15546612 12050117 12391150
EP300 MDM2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15154850 20234175 16713569 11070080 9809062 28196907 15013777
EP300 CEBPB â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28428115 9343424 14630807 12471036
EP300 TAL1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11756538 11118214 10490830
EP300 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19887647 11782371 12738788 25728767 11867769 12479814 23065768 15308690 20388208 14761960 22227247 8799122 20348541 23403292 12714702 11581164 16713569 19838210 18765668 16645043 30418174 12574227
MDM2 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9809062 11070080 16713569
STAT3 HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9880553 10440232 23228483
LARP7 HEXIM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18483487 30824372
MAPK3 PTPN6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16231973 12459785 23109003
AR MDM2 â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
AKT1 MDM2 â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
TRIM28 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16107876
KMT2A MEN1 â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
MEN1 SMAD4 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 22275377 11274402 15150273
MEN1 SMAD2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 22275377 11274402 15150273
TP53 MSH2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11350971 8630028
NELFB NELFA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10199401 15489290 11859374
NELFE NELFA â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 26496610 33961781 20305087 26186194 24981860 12612062
NELFA NELFB â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 26496610 33961781 20305087 24981860 12612062
PDS5A CSNK2B â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
AR PRKCD â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17553165 17178875
PRKCD TRIM28 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18590578
STAT3 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21546410
STAT3 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16107692 23874455 20043094
PTPN6 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18508557 15870198 10545526
STAT3 HSP90AB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18266962 12559950
TP53 CCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22804246 23666675 20406462
MSL2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19788416 19033443
HSPA1A TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 7811761 16713569 8729618
TP53 ETS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15469934 14586398
TP53 HSPA1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 7811761 16713569 8729618
ESR1 BARD1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17275994
CDC73 PAF1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 18469135 20178742 15632063 20305087 26496610 15923622 19136632 27462432 22939629 19410543 29774127 21726809 16024656 22863883 33961781 24981860 26186194 26344197
BCL10 AKT1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16280327 24462114 24412244
SMAD2 SMAD4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9111321 25514493 11927552 28443643 21988832 20211142 15467747 12732634 25609649 15922743 12419246 9288972 21454478 19139564 24157709 18729074 22442258 17283070 16916642 15350224 17591701 11274206 15761153 31591477 26555259 9892009 9311995 10085121 9389648 10781087 12167862 10878024 18783722 27703004 18511908 28468752 19135894 10531362 12794086 15231748 21297662 12621041 19917253 11027280 24584437 16751102 31932471 10199400 21532621 12808092 33961781 11264182 11102446 11114293 12543979 23788427 15817471
AKT1 SMAD4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16362038 23397142
SMAD1 SMAD4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9111321 17183365 16189514 32296183 31467278 12167862 14701756 12874272 28468752 15761153 24412244 10531362 15231748 11700304 11779505 26555259 9436979 21454478
SMAD3 SMAD4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9111321 16189514 25514493 11927552 28443643 21988832 20211142 15084259 12732634 19768112 15467747 20142324 25609649 15922743 12917407 12419246 20564330 24382352 19139564 32296183 24157709 18729074 22442258 10092624 17283070 15350224 17591701 15761153 31591477 10995777 26555259 9892009 9311995 15588252 12167862 10878024 25910212 27703004 33990575 28115363 18055455 22310290 19135894 10531362 12794086 15231748 21297662 22045334 19917253 24584437 27107012 29892012 29997244 21532621 27845895 21597466 25502805 11114293 12543979 23788427
SMAD4 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12226080 16713569
SMAD2 SMAD3 â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
SMAD2 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18729074 9111321
AKT1 SMAD3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16362038 25241761
SMAD3 MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15086314 23161884 16619037
SMAD3 CEBPB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12202226 12524424
CDK8 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 15546612
NOTCH1 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14597575 23331499 14500836
NCOR1 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16713569 24051437 12145334 16469706 17400812 12738788 21182203
AKT1 NCOR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 23940660
PTK2 HES1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CUL1 SKP2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 16189514 17704768 12840033 18667692 15456869 18239684 12504026 9636170 12609982 17439941 21145461 10559858 9736735 17438373 23951410 19398581 28614300 22464731 22013077 29137415 30349055 19270694 16774918 18173839 23770852 24085301 21249194 29499133 23868976 22310285 11961546 9430629 32313199 10559916 25143387 20160477 10230406 9663463 22524983 34237211 21119685 33422522 27542266 29103612 16880511
RELA AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16713569 8798655
MED12 CDK8 â—¼   PHYSICAL_INTERACTION ✅ 0.9 0.9 mint 30099503
MED26 CDK8 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15175163 20098423 24981860 21729782 23746844
MED28 CDK8 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 15175163 26496610 33961781 24981860 26186194 23602568 29568061
CDK8 MED1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 32707033 18418385 15989967 29568061 10024883 26496610 20098423 23322298 33961781 24981860 26186194 23602568 10198638 11867769 10882111
CDK8 MED24 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 32707033 29568061 10024883 26496610 23322298 20098423 33961781 24981860 26186194 23602568 10198638 26344197 11867769 10882111
CDK8 MED17 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 32707033 29568061 26496610 20098423 33961781 24981860 26186194 23749998 23602568 10198638 11867769 10882111
CDK8 MED12 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 30695077 20098423 23322298 19047373 27684187 11867769 20720539 10882111 15175163 30099503 26496610 23602568 29568061 23749998 32707033 23746844 33961781 24981860 26186194 10198638
CDK8 MED14 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 32707033 18418385 10024883 26496610 20098423 11416138 33961781 24981860 26186194 23602568 10198638 29568061 10882111
MED1 MED12 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 15175163 15989967 26496610 20098423 23322298 23563140 33961781 24981860 27684187 20133760 26344197
ESR1 MED12 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 26487511 11867769 31527615
CDK19 MED12 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 15175163 30099503 26496610 33961781 24981860 26186194 23749998 23602568 32707033 20133760 23746844
ETS1 CSNK2A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10849443 19027835
CEBPB FGFR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8183933 12184911 21562223
PPP1CC AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 14633703
CEBPB ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31527615 16651265 7651415 19652226 9817600
ESR1 PRKACA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11457657 10949931 17068199
GSK3A GATA6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 27273097
STIP1 HSP90AB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21170051 27353360
MED24 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9653119 12837248 11867769 31527615
MED1 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 18391015 15886699 31527615 10760302 12738788 9653119 10770935 12837248 11867769
ESR1 MED14 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19805454 11867769 10770935 31527615
ESR1 DDX17 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 20663877 19995069 25604459 12738788 11250900 21182205 20348541
AR GTF2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12648523 9238003
MED28 MED1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 15175163 15989967 33961781 24981860 20133760
MED1 MED24 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 18391015 15989967 20098423 9653119 33961781 24981860 22939629 20133760 26344197
MED1 MED17 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 18391015 15989967 20098423 33961781 24981860 17967894 20133760 26344197
MED1 MED14 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 15175163 9989412 18418385 15989967 20098423 33961781 24981860 22939629 20133760 26344197
NELFB NELFE â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 10199401 32296183 20211142 14667819 26496610 33961781 20305087 26186194 24981860 12612062 15342491
NELFE NELFCD â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10199401 15489290 11859374
MSL1 MSL2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 16227571 33961781 24981860 23084835
BRCA1 ESR1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
BRCA1 TP53 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
HSP90AA1 TP53 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
RNF20 RNF40 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
AKT1 GSK3A â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
AR NCOR1 â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
ERCC3 GTF2F1 â—¼   PHYSICAL_INTERACTION 904.0 0.9 STRING 36370105
NELFE POLR2A â—¼   PHYSICAL_INTERACTION 904.0 0.9 STRING 36370105
ERCC3 POLR2G â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
ERCC3 POLR2L â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
ERCC3 POLR2B â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
ERCC3 POLR2I â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
ERCC3 POLR2D â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
ERCC3 POLR2K â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
CSNK2A1 SUPT16H â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
POLR2J TCEA1 â—¼   PHYSICAL_INTERACTION 907.0 0.9 STRING 36370105
POLR2J SUPT4H1 â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
CDK8 MED24 â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
HEXIM1 CDK9 â—¼   PHYSICAL_INTERACTION ✅ 0.91 0.91 mint 6613869 18483487
LARP7 CDK9 â—¼   PHYSICAL_INTERACTION ✅ 0.91 0.91 mint 6613869 18483487
NELFCD NELFE â—¼   PHYSICAL_INTERACTION 909.0 0.91 STRING 36370105
FKBP5 HSP90AA1 â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
POLR2H SUPT5H â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
POLR2L SUPT5H â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
CDK19 MED12 â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
ATM TP53 â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
POLR2E SUPT6H â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
EP300 TP53 â—¼   POLYUBIQUITINATION ✅ - 0.91 0.91 Signor 12690203
CDK19 MED14 â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
HSP90AB1 PPP5C â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
CDK8 MED1 â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
CDK9 HEXIM1 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
CDK9 POLR2A â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
EP300 RELA â—¼   PHYSICAL_INTERACTION 922.0 0.92 STRING 36370105
CDK8 MED14 â—¼   PHYSICAL_INTERACTION 924.0 0.92 STRING 36370105
GTF2F1 TCEA1 â—¼   PHYSICAL_INTERACTION 925.0 0.92 STRING 36370105
EP300 HIST1H3A â—¼   PHYSICAL_INTERACTION 926.0 0.92 STRING 36370105
STIP1 HSP90AA1 â—¼   PHYSICAL_INTERACTION ✅ - 0.92 0.92 Signor 27353360
ERCC3 POLR2C â—¼   PHYSICAL_INTERACTION 928.0 0.92 STRING 36370105
NELFA POLR2C â—¼   PHYSICAL_INTERACTION 929.0 0.93 STRING 36370105
SUPT16H SUPT5H â—¼   PHYSICAL_INTERACTION 929.0 0.93 STRING 36370105
EP300 ESR1 â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
MED14 POLR2C â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
MED14 POLR2B â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
RNF20 UBE2A â—¼   PHYSICAL_INTERACTION 931.0 0.93 STRING 36370105
NCBP1 NELFE â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
MED14 POLR2A â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
MED26 POLR2G â—¼   PHYSICAL_INTERACTION 933.0 0.93 STRING 36370105
NELFA SUPT5H â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
POLR2K SUPT5H â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
HIST1H3A MLLT3 â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
POLR2L SUPT4H1 â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
POLR2K SUPT4H1 â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
NELFA POLR2A â—¼   PHYSICAL_INTERACTION 935.0 0.93 STRING 36370105
GTF2F1 POLR2K â—¼   PHYSICAL_INTERACTION 935.0 0.93 STRING 36370105
CDC73 SUPT5H â—¼   PHYSICAL_INTERACTION 936.0 0.93 STRING 36370105
CCNH POLR2A â—¼   PHYSICAL_INTERACTION 939.0 0.94 STRING 36370105
TCEA1 CDK8 â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 10454562 9305922
GTF2F1 POLR2J â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
POLR2I POLR2J â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
POLR2J POLR2L â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
ERCC3 POLR2J â—¼   PHYSICAL_INTERACTION 942.0 0.94 STRING 36370105
POLR2K TCEA1 â—¼   PHYSICAL_INTERACTION 944.0 0.94 STRING 36370105
MED14 POLR2D â—¼   PHYSICAL_INTERACTION 944.0 0.94 STRING 36370105
EP300 SMAD3 â—¼   PHYSICAL_INTERACTION 945.0 0.94 STRING 36370105
AKT1 HSP90AA1 â—¼   PHYSICAL_INTERACTION 946.0 0.94 STRING 36370105
CTDP1 POLR2B â—¼   PHYSICAL_INTERACTION 946.0 0.94 STRING 36370105
SUPT4H1 SUPT6H â—¼   PHYSICAL_INTERACTION 948.0 0.94 STRING 36370105
SUPT5H SUPT4H1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 24981860
SMAD4 SMAD1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 17183365 5219486
NOTCH1 MAML1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 23022380
SKP1 CUL1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 7304783 18818696
SKP2 SKP1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 6540196 18239684
POLR2L TCEA1 â—¼   PHYSICAL_INTERACTION 950.0 0.95 STRING 36370105
POLR2I SUPT4H1 â—¼   PHYSICAL_INTERACTION 950.0 0.95 STRING 36370105
POLR2I SUPT5H â—¼   PHYSICAL_INTERACTION 953.0 0.95 STRING 36370105
CTDP1 GTF2F2 â—¼   PHYSICAL_INTERACTION 953.0 0.95 STRING 36370105
GTF2F1 POLR2L â—¼   PHYSICAL_INTERACTION 953.0 0.95 STRING 36370105
POLR2D TCEA1 â—¼   PHYSICAL_INTERACTION 953.0 0.95 STRING 36370105
RNF40 UBE2A â—¼   PHYSICAL_INTERACTION 954.0 0.95 STRING 36370105
POLR2E SUPT4H1 â—¼   PHYSICAL_INTERACTION 954.0 0.95 STRING 36370105
BRD4 RELA â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
GTF2F2 POLR2L â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
GTF2F2 POLR2K â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
POLR2C SUPT4H1 â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
POLR2I TCEA1 â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
POLR2D SUPT4H1 â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
POLR2G SUPT4H1 â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
CCNT1 HEXIM1 â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
PAF1 SUPT5H â—¼   PHYSICAL_INTERACTION 958.0 0.95 STRING 36370105
POLR2J SUPT5H â—¼   PHYSICAL_INTERACTION 958.0 0.95 STRING 36370105
CDC34 CUL1 â—¼   PHYSICAL_INTERACTION 958.0 0.95 STRING 36370105
POLR2G TCEA1 â—¼   PHYSICAL_INTERACTION 958.0 0.95 STRING 36370105
ATR MSH2 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 14657349 21285353 33005030
DDX17 DDX5 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 22365833 15298701 19995069 22863883 33961781 24581491 10837141 22939629
AKT1 MDM2 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 32450252 25241761 18332867 12145204 19166854 15527798 20856200 11715018 23397142 11504915 11923280 21930127
NCBP2 NCBP1 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 24981860
PAF1 CDC73 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 24981860
ERCC3 GTF2F2 â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
SMAD1 SMAD4 â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
POLR2B TCEA1 â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
CDK8 POLR2A â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
GTF2F2 POLR2D â—¼   PHYSICAL_INTERACTION 962.0 0.96 STRING 36370105
GTF2F1 POLR2F â—¼   PHYSICAL_INTERACTION 962.0 0.96 STRING 36370105
GTF2F1 POLR2G â—¼   PHYSICAL_INTERACTION 962.0 0.96 STRING 36370105
GTF2F2 POLR2F â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
POLR2F POLR2J â—¼   PHYSICAL_INTERACTION 964.0 0.96 STRING 36370105
POLR2E TCEA1 â—¼   PHYSICAL_INTERACTION 964.0 0.96 STRING 36370105
POLR2F TCEA1 â—¼   PHYSICAL_INTERACTION 964.0 0.96 STRING 36370105
ATM ATR â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
HSP90AA1 PPP5C â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
ERCC3 POLR2A â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
POLR2D POLR2H â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
POLR2C TCEA1 â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
BARD1 BRCA1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 12431996 17525341 29367421 27977889 19916563 12732733 10477523 20060929 23680151 8944023 22110403 12951069 23086937 14638690 27239795 29355525 9788437 11925436 11257228 24289923 14647430 19176389 15184379 9738006 16403807 29180510 11278247 33589814 15265711 15159397 34408138 16713569 19117993 20681793 16391231 11301010 16489000 23416467 17664283 15569676 29858377 19369211 18493658 29656893 20351172 28398198 12485996 32347575 19766185 14636569 10026184 12700228 31270457 11573085 11526114 24085845 25823446 33961781 32092106 18936166 28514442 20215511 25184681 26490435 28948225 12890688 12438698 28262780 26831064 9342365 10635334 15855157 11504724 11773071 25252691 9798686 26350354 21901007 24695549 12887909 17873885 11498787 27454289 11927591 24981860 25652403 25634209
CDK7 CCNH â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 9334327 15698475 11113184 15328539 33707221 17643375 8078587 26340423 33476598 8521818 8521393 23602568 29568061 33453189 32707033 22939629 11713533 10958691 8692841 16782892 9218599 33961781 10082552 26186194 9056480 26344197
CDK9 CCNT1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 9499409 11145967 15328539 17643375 20562857 9491887 20305087 15713662 19387490 11713532 27684187 14627702 23455922 16980611 26659056 15107825 12588988 12944466 14580347 20153263 22959624 16109377 12115727 21729782 23602568 11282025 30649429 19914168 18483487 24367103 20535204 12832472 19818711 12894230 9872325 23064645 30652970 15713661 21697490 22483617 22939629 32707033 11713533 15528190 15546612 10958691 10617616 10574912 18566585 10465067 24981860 33961781 11689688 17700062 26186194 26344197
CDK9 CCNT2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 32707033 9499409 16331689 18566585 17643375 10465067 33961781 24981860 21729782 26186194 23602568 11282025 27684187 23455922 11713533 26344197
NCBP2 NCBP1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 16189514 23665581 9933612 26382858 31467278 11545740 22365833 26496610 29395067 12374755 26264872 7478990 19668212 22939629 29997244 32814053 29101316 24981860 31448526 17190602 12434151 26344197
SKP2 SKP1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 16189514 18667692 15456869 30254149 18239684 20041211 16275325 12609982 10559858 23911321 26087183 18818696 23261596 31467278 9827542 10918611 19398581 28614300 22464731 29137415 16376880 15452136 19270694 26474281 12813041 34080260 23770852 24085301 29499133 30728155 17463251 23868976 22310285 11961546 9430629 11099048 22632967 10559916 20160477 15469821 22524983 10531035 34237211 29997244 27705803 33422522 33961781 32350066 16880511 27220724 15070733 15342634
NCOA2 ESR1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 14766010 12612084 11250900 12837248 17697320 11376110 9430642 11265755 20348541 19460354 18499756 12630920 12714702 9192892 15657427 11014206 16645043 11937504 12554772 26487511 9774463
MED28 MED17 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 15175163 15989967 24882805 33961781 24981860 22939629 20133760
PAF1 SUPT16H â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
AFF4 CCNT1 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
BRD4 JMJD6 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
HSP90AB1 STIP1 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
NCBP2 NELFE â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
CSNK2B SUPT16H â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
GTF2F1 POLR2D â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
NELFA NELFB â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
POLR2D SUPT5H â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
AR NCOA2 â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
ATR CHEK2 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
ERCC3 POLR2E â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
ERCC3 POLR2F â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
GTF2F2 POLR2J â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
NELFB NELFE â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
AFF4 CDK9 â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
CDK9 CCNT1 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 6613869 18483487
TP53 EP300 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 16611888 6599495
NELFA NELFE â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
CSNK2B CSNK2A1 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 36833176
POLR2E POLR2J â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
GTF2F2 POLR2I â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
PAF1 POLR2A â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
HSP90AA1 STIP1 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
NELFA NELFCD â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
POLR2F SUPT4H1 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
POLR2F POLR2H â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
GTF2F1 POLR2I â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
POLR2F SUPT5H â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
POLR2G SUPT5H â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
POLR2F POLR2L â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
POLR2K POLR2L â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
POLR2B SUPT4H1 â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
GTF2F1 POLR2B â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
POLR2E SUPT5H â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
TP53 MDM2 â—¼   PHYSICAL_INTERACTION ✅ 0.99 0.99 mint 17139261 5219401
CDC73 POLR2A â—¼   PHYSICAL_INTERACTION 989.0 0.99 STRING 36370105
POLR2A POLR2J â—¼   PHYSICAL_INTERACTION 989.0 0.99 STRING 36370105
ESR1 NCOA2 â—¼   PHYSICAL_INTERACTION 989.0 0.99 STRING 36370105
GTF2F1 POLR2E â—¼   PHYSICAL_INTERACTION 989.0 0.99 STRING 36370105
POLR2D POLR2F â—¼   PHYSICAL_INTERACTION 989.0 0.99 STRING 36370105
GTF2F1 POLR2C â—¼   PHYSICAL_INTERACTION 989.0 0.99 STRING 36370105
POLR2H POLR2I â—¼   PHYSICAL_INTERACTION 989.0 0.99 STRING 36370105
POLR2A SUPT4H1 â—¼   PHYSICAL_INTERACTION 989.0 0.99 STRING 36370105
GTF2F2 POLR2C â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
CTDP1 POLR2A â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
POLR2G POLR2J â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
POLR2D POLR2J â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
MAML1 NOTCH1 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
CTDP1 GTF2F1 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
GTF2F1 POLR2A â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
POLR2D POLR2K â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
MSL1 MSL2 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
BRCA1 POLR2A â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
CCNK CDK12 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
CDK7 POLR2A â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
CCNT2 CDK9 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
SUPT5H SUPT6H â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
POLR2J POLR2K â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
POLR2A TCEA1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
POLR2C SUPT5H â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
NCBP1 NCBP2 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
GTF2F2 POLR2G â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
POLR2I POLR2L â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
POLR2A SUPT6H â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
POLR2A SUPT5H â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
POLR2B SUPT5H â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
CDC73 PAF1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
POLR2D POLR2E â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
GTF2F2 POLR2E â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
POLR2E POLR2I â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
GTF2F2 POLR2B â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
GTF2F2 POLR2A â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
POLR2F POLR2I â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
POLR2D POLR2L â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
POLR2G POLR2K â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
POLR2I POLR2K â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
POLR2C POLR2D â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
POLR2C POLR2I â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
POLR2G POLR2I â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
POLR2D POLR2I â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
POLR2D POLR2G â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
SUPT4H1 SUPT5H â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
POLR2B POLR2J â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
POLR2B POLR2F â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
BARD1 BRCA1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCNH ERCC3 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EP300 TP53 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
MDM2 TP53 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
POLR2E POLR2F â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
POLR2E POLR2H â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
POLR2E POLR2K â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
POLR2E POLR2L â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
GTF2F1 GTF2F2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
POLR2F POLR2K â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
POLR2H POLR2L â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
POLR2H POLR2K â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
POLR2B POLR2H â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
POLR2A POLR2H â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
POLR2G POLR2H â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
POLR2C POLR2H â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
POLR2B POLR2I â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
POLR2A POLR2I â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
POLR2B POLR2D â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
POLR2A POLR2D â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
POLR2B POLR2G â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
POLR2A POLR2B â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ACTL6A ATM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16141325
BRCA1 ATM â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
ATM BARD1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
ATM BRCA1 â—¼   ENZYMATIC_REACTION ✅ 54.0 1.0 ACSN 11331603 11438669 11804596 11877377 12086603 12556884 12607003 14988723 15136767 15140942 15175241 15459660 15485915 15798197 15867354 15964794 16163361 16332722 16581787 16713580 16731533 16805667 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17713585 18006705 18048416 18469862 18511906 18583988 18716619 18756267 18995830 19151707 19282663 19342888 19357644 19490890 19622404 19788416 19793801 19793861 19841479 20019063 20051983 21376743 23847781 9168117 9858600
ATM CHEK2 â—¼   ENZYMATIC_REACTION ✅ 59.0 1.0 ACSN 11331603 11850621 11877377 12086603 12556884 12607003 14614141 14988723 15136767 15140942 15175241 15242590 15279786 15375219 15377654 15459660 15485915 15798197 15964794 16163361 16332722 16531125 16713580 16805667 16818604 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17660363 18006705 18087292 18469862 18543256 18583988 18584027 18590585 18678890 18809224 18995830 19151707 19282663 19342888 19622404 19686080 19772495 19793801 20051983 20723763 21376743 22743550 23847781 24050180 7575488 9407949 9488723
ATM TERF1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11331603 11877377 12607003 15140942 15459660 15964794 16163361 17303408 22266654 22634377 23847781
ATM MDM2 â—¼   ENZYMATIC_REACTION ✅ 54.0 1.0 ACSN 11331603 11438669 11804596 11877377 12086603 12556884 12607003 14988723 15136767 15140942 15175241 15459660 15485915 15798197 15867354 15964794 16163361 16332722 16581787 16713580 16731533 16805667 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17713585 18006705 18048416 18469862 18511906 18583988 18716619 18756267 18995830 19151707 19282663 19342888 19357644 19490890 19622404 19788416 19793801 19793861 19841479 20019063 20051983 21376743 23847781 9168117 9858600
MSH2 ATM â—¼   UP_REGULATES ✅ + 20.0 1.0 ACSN 12556884 12947387 15136767 15703371 16332722 16612326 16697054 16713580 16858402 17303408 18157157 18406444 18543256 19151707 19473888 19595721 19596235 19596236 19847258 20478261
PPP5C ATM â—¼   REGULATES ✅ 27.0 1.0 ACSN 12086603 12556884 14871926 14988723 15136767 15175241 15459660 15798197 16260606 16332722 16713580 16805667 16858402 17102137 17116885 17296725 17303408 17384638 17582221 18469862 18995830 19151707 19282663 19342888 19622404 19793801 20051983
PPP5C ATM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 18772547 17376776 17303408 16858402 19151707 14871926 16260606 16332722 12556884 15459660
ATR ATM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15510216 10608806 17478428 17124492
ATM TERF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16223874 17525332 15314656
ATM EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 20471956 15494392 15140942 29590107 26170237 21108945 15838517 27220480
ATM TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 452.0 1.0 Omnipath 25301947 21720806 23549171 10713094 16501611 15077171 24886358 17570479 19375142 22028490 16916644 14712210 19303885 9407038 11927276 26700820 28356518 15226429 10723129 19788889 12064478 19705844 26673821 22179422 20931131 19062161 27030982 22891162 17157788 19056039 15758953 12049739 15361830 26620371 25865756 22615843 10196661 10656682 11313957 25088203 15140942 12519769 16319535 24469230 12776195 17234789 27511909 29238697 24608431 12927814 16783362 11875057 16436515 22778557 15181149 12702572 10500142 15178764 28842590 28145533 11591448 17855337 22726545 20206688 26824362 21317290 26104798 24704793 9765199 11314044 16906133 17174997 21593792 17967874 10771484 15585169 19625493 15178448 17596534 16288207 15048074 18353733 24057508 19535302 29344296 23708100 29872395 23705030 25043304 33761896 18431490 21404020 15024084 22559321 12151394 24078877 12080066 33982778 16893723 10958792 18289945 27183917 26337656 29170437 18765533 10744722 21748595 18056442 24820418 15489892 16390936 24086335 28140789 23091651 34523970 32001619 23418564 15279808 21317932 21188172 27559048 16818505 17616578 11551930 19010925 11709713 24711418 28654064 18339864 11173129 17486112 10570149 29774100 18381438 21994612 29558908 15258567 9372954 25860929 16858402 33692124 15775976 34107253 19923893 24958101 10436023 14752509 19962312 19071090 26438152 26093282 20123963 22444248 9843217 17525332 15456784 23533526 11780126 20353948 29290977 11096068 28102346 18855897 20372057 24395704 23890999 15725625 15806145 34103468 18345031 16997395 16293623 28477117 19828454 27630139 12071847 22002314 21315088 27177180 12645530 12890678 26113041 15794754 18560558 22099307 9885574 28903382 15665826 24877058 18332866 10611322 24380814 14871840 19934315 22975381 16489034 18406507 21440540 33687951 10608806 23892398 20730097 16914171 15782130 15177184 22055193 18490454 25867001 24349352 18045533 20663147 17535811 20506250 23982736 22375140 15700044 15279774 19266268 24358288 18697815 14729946 20637859 12242661 12771937 17371838 31940492 19409520 10528155 24037342 17257427 11121242 15310764 23148227 28915641 26928575 21423215 11865061 16949371 27810895 18449195 20711232 27389279 22213803 16713569 10446957 22797063 16478990 29048667 15489221 17241873 21187893 21441950 23907539 20005840 9733514 26244501 21614094 12082529 10467728 10714958 32061892 16636671 29147215 10673501 12091386 25202122 21465263 19544417 25823026 24078903 24038750 22198295 21480565 15177039 28182994 28208785 18674635 20183804 18818083 9925639 17712528 15254178 11483158 27940348 26675349 26261212 19717643 12606585 24559687 14871926 23150668 21329876 28153791 12518062 12767922 23824039 11711532 19251701 28118604 15078887 12393500 17456577 20976220 23380594 12519780 20810927 15533933 22420423 17108107 20145032 18032786 18785202 22037398 23184057 31968249 16729035 12588868 21614932 11546806 18614045 14757188 15029243 14968111 22649771 25512053 34496248 18604166 17609585 17976513 16223874 25433195 18985806 9363941 15159397 34282274 29301278 24505404 26056062 23577291 18272544 18715874 19536869 29334356 10801407 15155458 25201202 24376853 19907922 23525106 14643431 28340339 28051100 19085961 15212693 22201816 20026654 16322229 20080565 9733515 15632067 18672098 22577550 25691451 12637545 12548019 11672523 26984736 12324477 16552184 22084686 10864201 14744854 21532626 17118344 19482562 9561848 12511424 17668048 23358251 18511169 21460853 22022355 12939400 21415014 17292432 25651062 23168260 12111733 16648554 30361254 23678107
ATM CCAR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 26158765 23357756 26194823 27503537 22735644 24567900 17525332
ATM RNF20 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21763684 21362549 26184323 17525332
ATM SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22588298 23277204
ATM CHEK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 176.0 1.0 Omnipath 26683224 17303408 28852018 10713094 20080130 27545311 9488723 15342622 23941746 26485758 28937603 15279786 24882580 10744722 15125777 25746763 18583988 28051860 17570479 16531125 21329876 23892398 19607708 16940182 26643553 20396397 28259974 25361978 17660363 15459660 19375317 25247188 16311512 23118481 20498628 22030216 25613496 22420423 9407949 17918214 12493754 20859824 26158765 15700044 27558808 11901158 27602502 20637859 16163361 20599567 23638118 16481012 12242661 23847781 12024051 15140942 11728459 12454775 16936775 25450480 28950914 26295265 20160490 22319212 24349411 18006705 20723763 18678890 12805407 20860841 23386996 24050180 11668173 27271602 29304495 12447382 24798733 9889122 23347679 18794134 21147465 21421565 26516160 17715138 21376743 19440053 12773400 10973490 17174984 26442630 15694385 11877377 29022904 18809224 11850621 18787700 12718885 19481982 22743550 20372057 15212693 16085488 19101576 29555944 25954303 24473398 18087292 16794575 24492479 24244353 19793801 25404613 21102523 29156743 23253087 16997395 7575488 25808488 20647331 18584027 21851590 21315088 23705030 15629715 29741650 21772273 11025670 18590585 26610585 15964794 29434792 20068082 23006513 19881958 19230643 12607003 24769180 25249630 15024084 19772495 25714019 18603484 25173936 23666059 19473886 27568553 22808196
ATM MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 66.0 1.0 Omnipath 14654783 12383858 17936559 20651945 17303408 19816404 10611322 23150762 23277204 23386996 26416444 27258263 23002429 11331603 15865937 21556066 16163361 23708100 17570479 20514355 22264782 27177180 18265945 28690977 23847781 22264786 15140942 15964794 19788416 22624716 25201202 27462439 12607003 28050229 32350255 22649771 27956626 15459660 22976441 25247188 28904407 11877377 21859827 24534650 23405218 29290977 27568562
ATM TERF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 17145710 17717821 15314656 17570479 23732473 26586433 11375976 22266654
ATM BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 79.0 1.0 Omnipath 26927092 17303408 15159397 24746700 12024016 10866324 30197789 12919958 11114888 26745677 26383678 34301763 12427729 11313470 16163361 28035057 20068231 25939603 26320175 17570479 19683496 22743550 10608806 23802008 23847781 21203981 15964794 12183412 12607003 17525332 19996295 15459660 11278964 19651622 21706030 11877377 20952512 10373534 19622773 10550055 27170701 15212693 23704879
ATM TRIM28 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 73.0 1.0 Omnipath 25128619 22496453 34194047 30323812 26158765 16862143 28607002 19584288 20858735 28851455 18285803 34419074 17833484 22491012 25404613 21642969 28439615 27364555 27602502 26671524 23096706 23935532 28739276 24754998 25905708 28847822 24461736 23318425 23346550 17178852 27432546 27820601 17942393 21868291 32060145 22205726 25846574 26293668 25533843 23034801 23352131 28249048 23633913 17525332 18657500 24794298 23645696 26212333 23050241 22715096 27376578 23370278 24657165 29540829 25173936 19071136 28847828 20424263 34518220 25956864 23554604
ATR ATRIP â—¼   PHYSICAL_INTERACTION 61.0 1.0 ACSN 10884395 11756412 11877377 12086603 12466554 12766152 12875843 14614141 14624239 14657033 14726013 14988723 15136767 15175241 15189446 15242590 15375219 15377654 15459660 15485915 15703371 15743907 15798197 16530042 16697054 16713580 16805667 16818604 16880517 16885023 16934469 17035102 17102137 17116885 17141802 17296725 17303408 17384638 17582221 17855402 18157158 18451105 18469862 18543256 18677104 18931676 18995830 19158510 19217833 19225445 19258535 19282663 19342888 19622404 19686080 1974050 19793801 19847258 20051983 22021614 23414611
ATR CLSPN â—¼   PHYSICAL_INTERACTION 61.0 1.0 ACSN 10884395 11756412 11877377 12086603 12466554 12766152 12875843 14614141 14624239 14657033 14726013 14988723 15136767 15175241 15189446 15242590 15375219 15377654 15459660 15485915 15703371 15743907 15798197 16530042 16697054 16713580 16805667 16818604 16880517 16885023 16934469 17035102 17102137 17116885 17141802 17296725 17303408 17384638 17582221 17855402 18157158 18451105 18469862 18543256 18677104 18931676 18995830 19158510 19217833 19225445 19258535 19282663 19342888 19622404 19686080 1974050 19793801 19847258 20051983 22021614 23414611
ATR CLSPN â—¼   SHARES_COMPLEX 61.0 1.0 ACSN 10884395 11756412 11877377 12086603 12466554 12766152 12875843 14614141 14624239 14657033 14726013 14988723 15136767 15175241 15189446 15242590 15375219 15377654 15459660 15485915 15703371 15743907 15798197 16530042 16697054 16713580 16805667 16818604 16880517 16885023 16934469 17035102 17102137 17116885 17141802 17296725 17303408 17384638 17582221 17855402 18157158 18451105 18469862 18543256 18677104 18931676 18995830 19158510 19217833 19225445 19258535 19282663 19342888 19622404 19686080 1974050 19793801 19847258 20051983 22021614 23414611
ATR ATRIP â—¼   SHARES_COMPLEX 61.0 1.0 ACSN 10884395 11756412 11877377 12086603 12466554 12766152 12875843 14614141 14624239 14657033 14726013 14988723 15136767 15175241 15189446 15242590 15375219 15377654 15459660 15485915 15703371 15743907 15798197 16530042 16697054 16713580 16805667 16818604 16880517 16885023 16934469 17035102 17102137 17116885 17141802 17296725 17303408 17384638 17582221 17855402 18157158 18451105 18469862 18543256 18677104 18931676 18995830 19158510 19217833 19225445 19258535 19282663 19342888 19622404 19686080 1974050 19793801 19847258 20051983 22021614 23414611
MSH2 ATR â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 12556884 12947387 15136767 15703371 16332722 16612326 16697054 16713580 16858402 17303408 18157157 18406444 18543256 19151707 19473888 19595721 19596235 19596236 19847258 20478261
ATR MDM2 â—¼   ENZYMATIC_REACTION ✅ 42.0 1.0 ACSN 11438669 11877377 14988723 15136767 15459660 15485915 15798197 15867354 16332722 16540648 16713580 16731533 16885023 17102137 17116885 17296725 17303408 17384638 17582221 18048416 18511906 18543256 18677104 18716619 18756267 18931676 18995830 19004803 19282663 19357644 19490890 19622404 19686080 19772495 19788416 19793801 19793861 19841479 20019063 20051983 9488723 9858600
ATR CLSPN â—¼   ENZYMATIC_REACTION ✅ 61.0 1.0 ACSN 10884395 11756412 11877377 12086603 12466554 12766152 12875843 14614141 14624239 14657033 14726013 14988723 15136767 15175241 15189446 15242590 15375219 15377654 15459660 15485915 15703371 15743907 15798197 16530042 16697054 16713580 16805667 16818604 16880517 16885023 16934469 17035102 17102137 17116885 17141802 17296725 17303408 17384638 17582221 17855402 18157158 18451105 18469862 18543256 18677104 18931676 18995830 19158510 19217833 19225445 19258535 19282663 19342888 19622404 19686080 1974050 19793801 19847258 20051983 22021614 23414611
ATR BRCA1 â—¼   ENZYMATIC_REACTION ✅ 42.0 1.0 ACSN 11438669 11877377 14988723 15136767 15459660 15485915 15798197 15867354 16332722 16540648 16713580 16731533 16885023 17102137 17116885 17296725 17303408 17384638 17582221 18048416 18511906 18543256 18677104 18716619 18756267 18931676 18995830 19004803 19282663 19357644 19490890 19622404 19686080 19772495 19788416 19793801 19793861 19841479 20019063 20051983 9488723 9858600
ATR CHEK2 â—¼   ENZYMATIC_REACTION ✅ 42.0 1.0 ACSN 11438669 11877377 14988723 15136767 15459660 15485915 15798197 15867354 16332722 16540648 16713580 16731533 16885023 17102137 17116885 17296725 17303408 17384638 17582221 18048416 18511906 18543256 18677104 18716619 18756267 18931676 18995830 19004803 19282663 19357644 19490890 19622404 19686080 19772495 19788416 19793801 19793861 19841479 20019063 20051983 9488723 9858600
HES1 ATR â—¼   UP_REGULATES ✅ + 35.0 1.0 ACSN 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 8020957
MSH2 ATR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 19847258 16612326 14657349 16713580 20478261 15703371 18543256 12947387 19473888 19595721 19596235 18157157 16697054 19596236 18406444 21285353
ATR BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 54.0 1.0 Omnipath 26927092 17478428 24746700 15159397 17531442 10866324 18677104 19622404 15798197 19793801 20860841 16713569 11114888 23422745 20936109 16322207 19282663 20068231 17116885 17582221 25879655 10608806 17384638 23346553 12773400 12183412 17525332 15459660 11278964 17296725 11877377 17102137 10550055 16522651
ATR CLSPN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 18309293 24500207 19473886 12766152 18077418
ATR CHEK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 38.0 1.0 Omnipath 21722802 20859824 26683224 18677104 19622404 15798197 19793801 27545311 23137030 19836377 20647331 20599567 19282663 19658174 17116885 16481012 17582221 11715017 17384638 29741650 12024051 18802408 10973490 9857181 26442630 15459660 17296725 11877377 17102137 12493754
ATR CCAR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 24126058 26158765 22735644 24567900 18077418 26657080
ATR MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 14654783 17296725 20651945 11877377 19788416 18677104 19282663 15798197 17102137 17116885 17582221 19622404 19793801 17384638 15459660
ATR ATRIP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 20616048 15451423 19889979 23144622 17686975 18344416
ATR KMT2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 25841987 27308325 24148750 20818375 4709074 27220480
ATR XRCC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23438602 26354865
ATR TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 106.0 1.0 Omnipath 17145710 22778941 24395704 28468838 12401524 15159397 24877058 15254178 9733515 11483158 15806145 19056039 11875057 15865930 11551930 11883897 19923893 12548019 18697815 29170437 16293623 19010925 11709713 10446957 9363941 21748595 17272272 22797063 12242661 10196661 22084686 10747897 10608806 10673501 12091386 17118344 23892398 9765199 15489221 24037342 15140942 10435622 17241873 10597277 10801407 11711532 17174997 21593792 25201202 9843217 10606744 15024084 15226429 15922368 21415014 21480565 15585169 24947324 9925639 23380594 9733514 11865061 19625493 16390936 10951572 10570149 23311997 12111733 26144601
ATRIP CLSPN â—¼   PHYSICAL_INTERACTION 61.0 1.0 ACSN 10884395 11756412 11877377 12086603 12466554 12766152 12875843 14614141 14624239 14657033 14726013 14988723 15136767 15175241 15189446 15242590 15375219 15377654 15459660 15485915 15703371 15743907 15798197 16530042 16697054 16713580 16805667 16818604 16880517 16885023 16934469 17035102 17102137 17116885 17141802 17296725 17303408 17384638 17582221 17855402 18157158 18451105 18469862 18543256 18677104 18931676 18995830 19158510 19217833 19225445 19258535 19282663 19342888 19622404 19686080 1974050 19793801 19847258 20051983 22021614 23414611
ATRIP CLSPN â—¼   SHARES_COMPLEX 61.0 1.0 ACSN 10884395 11756412 11877377 12086603 12466554 12766152 12875843 14614141 14624239 14657033 14726013 14988723 15136767 15175241 15189446 15242590 15375219 15377654 15459660 15485915 15703371 15743907 15798197 16530042 16697054 16713580 16805667 16818604 16880517 16885023 16934469 17035102 17102137 17116885 17141802 17296725 17303408 17384638 17582221 17855402 18157158 18451105 18469862 18543256 18677104 18931676 18995830 19158510 19217833 19225445 19258535 19282663 19342888 19622404 19686080 1974050 19793801 19847258 20051983 22021614 23414611
MSH2 ATRIP â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 12556884 12947387 15136767 15703371 16332722 16612326 16697054 16713580 16858402 17303408 18157157 18406444 18543256 19151707 19473888 19595721 19596235 19596236 19847258 20478261
ATRIP CLSPN â—¼   ENZYMATIC_REACTION ✅ 61.0 1.0 ACSN 10884395 11756412 11877377 12086603 12466554 12766152 12875843 14614141 14624239 14657033 14726013 14988723 15136767 15175241 15189446 15242590 15375219 15377654 15459660 15485915 15703371 15743907 15798197 16530042 16697054 16713580 16805667 16818604 16880517 16885023 16934469 17035102 17102137 17116885 17141802 17296725 17303408 17384638 17582221 17855402 18157158 18451105 18469862 18543256 18677104 18931676 18995830 19158510 19217833 19225445 19258535 19282663 19342888 19622404 19686080 1974050 19793801 19847258 20051983 22021614 23414611
ATRIP BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 24073851 17616665
BCL2 TRAF2 â—¼   DOWN_REGULATES ✅ - 8.0 1.0 ACSN 11704864 17446862 22039431 23064052 23377657 23430059 23850759 8929532
RELA BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 17673602 18031796 12835724 15120608 20332461 14978135 20446017 18566231 19259124 14739605 21503108 20103608 17098279 18158998 19233129 16022909 18761399 18191642 21224428 16453001
AR BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17655826 11567031 23160675 20610535
ESR1 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 19148464 19160418 9306964 11261829 21841772 10542244 20664923 18414489
TP53 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 41.0 1.0 Omnipath 17693666 8183578 10037739 16738310 18397889 19521340 18487508 21666495 16294215 21656028 22869582 19714248 10744634 8174112 17592775 11782367 19137013 20428827 18682598 11713302 11313951 20501806 9649502 24814047 15767042 24098340 11193470 10329733 21859835 22266868 10953306 19555669 23638218 14684736 19411072 20530667 24155778 8205530 20840522 9000137 15326476
STAT3 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 12400004 15805299 20514402 15184887 17997399 18320073 20880395 17089128 20446017 20422978 18981713 21344490 19287190 19103760 20043094 16144938 20233902 21172343 18839277 14523036 10626893 19926637 21435102 22504301 11431352 21385902 22313388 16048438 22984561
MAPK3 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 9115213 10669763 9735392 11323415 21785723 9738012 10677502 23272207 25826088
TP53 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 12667443 19555669 8205530 19007744 11313951
AKT1 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 21303971 11882383 17680028 20214616 22094462 20398329 21506126 20028971 12040186 18218901
BRCA1 BARD1 â—¼   PHYSICAL_INTERACTION 36.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19342239 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
BRCA1 XRCC3 â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
BRCA1 BARD1 â—¼   SHARES_COMPLEX 36.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19342239 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
BRCA1 XRCC3 â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
CHEK2 BRCA1 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 11438669 15459660 15810020 15867354 17296736 17464182 17568790 18048416 18566216 18756267 18931676 18971944 19686080 19788416 20019063 20126263
TP53 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 24.0 1.0 Omnipath 9582019 11295099 18625847 11003642 12802282 16357511 14710355 9619832 19882681 10884389 11384963 11782367 12024039 15735697 12170778 21245169 17993233 12549011 11431698 16229810 18208621 10597265 21742769
BARD1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 99.0 1.0 Omnipath 16403807 16391231 28262780 15159397 25652403 26350354 26490435 14647430 11927591 25184681 16713569 11526114 35203293 9738006 12732733 24289923 11573085 18936166 23086937 24085845 12890688 15855157 24695549 19369211 9798686 11257228 11498787 12700228 11925436 10477523 19176389 23680151 25634209 23416467 34726323 29355525 18369654 14636569 11504724 12951069 19117993 20060929 17873885 14638690 18493658 11278247 15184379 22110403 11301010 11773071 12431996 10635334 20029420 9788437 17664283 21901007 25252691 12485996 10026184 12438698 17525341 16489000 8944023 15265711 12419249 20681793 9342365 27239795 20215511 25823446 19916563
CHEK2 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 43.0 1.0 Omnipath 18566216 15810020 24492479 20860841 16713569 26383678 10724175 12049740 24986639 23388117 14701743 30327455 33397362 22921572 18804494 24348208 20364141 22941656 15459660 17464182 20952512 24069304 15485917 22193408 12111733 27170701
AKT1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 17428466 20832017 20085797 21242970 17570479 10542266
BRCA1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11085509 16713569 11016951
BRCA1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 11244506 12400015 15674350 10334989 16713569 11493692
BRD4 CDK9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17690245 24832049 19723344 16109376 23596302 23027873 26659056 18971272
CCND1 CCNH â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 Reactome 8139570 20107323 16782892 23622515 23737759 19487459 19075005 7954814 19458076
CCND1 CDK7 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 Reactome 8139570 20107323 16782892 23622515 23737759 19487459 19075005 7954814 19458076
RELA CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 17673602 18226221 10464245 18566231 19800042 18174238 15755876 18341653 11861406 20103608 12894581 17098279 22306268 20922712 16998474 10409765 19766095 15756023 21056029 22835384 17407600 15870875 18184402 17944672 15856023 20538607 19263436 16453001
ESR1 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 11477579 12554765 12808053 17166846 22892083 21505052 18414489 9832502 23864650 22396492 22266855 11358796 23891847 22948256 11986316 15282324 15496458 22521644 14764652 15178330 23108396 11410592 15026472 17998543 17681750 18245487 20821348 16860316 11844790 19858209 12929585 15808510 18997820 15217513 16809759 10500157 16980581 17914104
TP53 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 24189068 8702807 10669755 22270849 12808109 17942917 19086036 20731879 16061648 20554748 24460719 11798189 10082575 15205322 18769160 19800042
STAT3 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 16510571 19880237 17997399 15469392 16651438 21163886 22566696 16912181 22349830 16384639 12147685 21344490 20160059 19506034 20332458 23329648 11114718 17761947 22218594 15994929 21172343 18988190 18177723 24499623 21435102 19926637 18184402 17344214 22313388 23950841
EP300 CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 17306568 17666529 11788592 23343194 21285352 15576399 21151179 22761862 22290435 16039586 19619488 19623618 17143292
CCNH CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 7533895 19847258 12814430 17386261 16782892 17884153 19667075 15703371 12648680 11900249 12459251 16697054 19809470
ESR1 CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8649771 11073968 16061635 9039267
CDK7 CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 7533895 19847258 12814430 17386261 16782892 17884153 19667075 15703371 12648680 11900249 12459251 16697054 19809470
CCNH CDK7 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
CDK8 CCNH â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 28238659 10993082
CCNH CDK7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 23602568 11113184 8521818 16782892 15698475 15328539 19153657 10082552 26340423 8692841 26186194 9334327 10958691 10734072 9056480 9218599 8078587 8521393 17643375
CDK7 ERCC3 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
CDK7 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 10734072 24424504 25943391 21820033 21157430 28638477
CDK7 ETS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20725631 15494306
CDK7 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 30257348 10949034 15461668 9528769 22879364 12118371 28423697 27748765 15059947 16076840 7491495 12093745 23850489 15528270 7838153
CDK7 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 17591690 11709713 12064478 1088347 16083285 9372954 11483158 9620776 10348343 10884347 16552184 9315650 11007451 9571186 10747897 17898864 1454855 11585729
CDK7 POLR2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 18079403 27197304 26799765 10886368 14662762 16327805 24662513 26748711 25561469 21331744 19667075 18079404 22137580 9130709 20457598 19901026 19450536 20932174
CCNT1 CDK9 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
CDK9 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 19914168 19914161
CDK9 SUPT5H â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 10757782 16327805 16427012 26399478 11575923 11145967 19941815 25849141
CDK9 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 19914168 19914161
CDK9 NCOA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22158970 33593309 29170386
CDK9 POLR2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 22053051 20222012 25023704 14662762 10364292 20106982 18066052 30135578 24385927 18644870 18329373 14517250 20932174 12052871 20226668 19575011 8416977 11575923 16735508
CDK9 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 24173284 9372954 11483158 9315650 19413330 19664995 23603988 24202322 11709713 16083285 1088347 16552184 10884347 24286312 10747897 17942552 16741955 17287340 92065884 12064478 10348343 14702041
CHEK2 TP53 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 10710310 10673501 10570149 10673500
TP53 CHEK2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 15326376 19435816 10531348 19395378 15044452
CSNK2B CHEK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15940255
CHEK2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 111.0 1.0 Omnipath 18778462 25545885 16893723 15254178 18833288 23892398 12052256 18319725 25372714 15459660 20514219 25174607 28140789 17339337 22420423 18566216 20950777 20651945 15810020 15700044 22891162 17157788 11551930 18725978 10724175 15467443 23351141 20096447 11063934 11709713 15659650 12242661 10656682 15140942 20041275 11728459 18614044 12781359 22649771 18812180 11173129 10570149 15279785 20081365 20860841 11875057 22778557 19923893 24553354 22797063 26384650 23316480 15489221 19788416 10801407 21187893 9843217 9733514 10710310 24358900 21526939 23843721 29805302 9733515 25404613 12548019 21625617 10673501 11447225 17118344 26610585 19544417 28038466 12810724 25823026 15024084 17464182 15862297 19933256 20526329 12111733 20183804 23144912
CHEK2 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 15862297 10710310
CEBPB DDIT3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 8051100 16757577 10085237 8662954
CSNK2A1 DDIT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 12876286 27650555
DDX5 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 24219989 15660129 20876186 19626115
AKT1 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 17623675 18182168 16926151 20333651 19158375 17964260 17570479 11116148 25904863 21901101 23275565 16024795
PRKCD EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 11020388 17434128 12379484 15006641 18053091 15212693 12590608
MAML1 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19304754 16530044 12391150 12050117
EP300 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 19608861 25400040 11567019 12419806 17617622 11533489 20333651 12456660 15152190 16846590 9096323 20064247 16382138 16713569 15171256 16135789
EP300 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11971970 10779504 24480624 17011549 16713569
EP300 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 137.0 1.0 Omnipath 11907332 25545885 21187340 10706102 16438982 10490106 19339993 15542844 23010591 11433299 19608861 17438265 17906639 16024799 9194564 20234175 23402884 12162806 26229107 16959611 15186775 9744860 11070080 17977830 17189186 22266186 20228809 15664194 19805293 25753752 11804596 26625199 27818144 10648616 16928824 9288740 10942770 12724314 23148227 23728348 15965232 19218448 16678111 16782091 20094059 14612423 24821727 10518217 16713569 9891054 25288747 17452980 14759370 19788416 25156994 18931695 22074660 23880760 15337767 15509808 26302407 22731250 18391200 16543236 19234109 21471221 23307557 25867071 12690203 15558054 18612383 23870121 18243116 19217391 22013068 16537920 16611888 18485870 9194565 12660246 9809062 23796514 11359905 12501250 15295102 19407812 25651062 23329847 16135789
EP300 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 21988832 23331499 9169454 12237408 10199400 11264182 7878020 8047140 12958365 19171760 11371641 16027720 17074756 17469772 21269274 15623506
EP300 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 18782771 15509516 8756628 10205054 7530500 15653507 15735682 19506034 16285960 16713569 11322950 7499365 15649887 9590694
EP300 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 9843571 19419955 22033265 9679056 21269274
EP300 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12419246 14500836 10673036 22298955
EP300 NCOA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15731352 20448036 10490106 9920895
EP300 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 9843571 11134049 12743039 15133024 15824515 15623506 16876108 21567395 16109717 17074756 20564330 10497242 15588252 17469184 15345715 11058129 10575014 16862174
GTF2F2 ERCC3 â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 Reactome 7151173 1310361 8490964 9405375 8156590 10723029 10024882 8946909
ERCC3 GTF2F1 â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 Reactome 7151173 1310361 8490964 9405375 8156590 10723029 10024882 8946909
AR FKBP5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15821585 19433513 20048054 21809344 11867260 16210365 20610535 17142810
TP53 HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15358769 15284248 24451373 18996350
STIP1 HSP90AA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 24.0 1.0 Omnipath 10642522 21235734 21360678 26804907 11413142 24949977 19875381 10786835 20704274 21170051 26496610 27353360 25036637 19996313 9452498 18285346 24462205 22315411 20159553 22729780 22504172 11877417
STAT3 HSP90AA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 18266962 16189514 12559950
HSP90AA1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 12427754 10557093 21460846 16713569 11507088
HSP90AA1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 1525041 19805354 20048054 15861399 17974989 26342197 17353003 26196320 16713569 27903893 1540595 21157430 19706771
HSP90AA1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 19356729 18266962 10995457 25714412 16189514 12176997 12586360 15843522
HSP90AA1 PPP5C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10400612 16531226 21360678 15577939 15383005
RELA IL1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 27371733 21131967 23195252 17612514 27076634 21106671
FGFR4 MAPK3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
ELK1 MAPK3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 8386592 11145955 7588619 7889942
FGFR1 MAPK3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
ETS1 MAPK3 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 8552081 10358095 20534573 11782450 15572696
MAPK3 SMAD2 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 10197981 16156666 27153775 29577978
MAPK3 SMAD3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 10197981 16156666 27153775 29577978
MAPK3 CEBPB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 16009338 12213825 8384717 10995751 12048245 15878863 19327116 19443782 15212693 15367685
MAPK3 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 47.0 1.0 Omnipath 17081983 16156666 19413330 11027280 9620846 33676893 23331499 8226933 20068231 18988627 12193595 18491316 18691976 8388392 19651622 10197981 18775330 19115199 9604935 15212693
MAPK3 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 73.0 1.0 Omnipath 18448488 19413330 11335711 9343414 23331499 15465816 25584415 12576423 11350938 20068231 12681450 10417333 12763138 9872331 18988627 11780390 18491316 18669648 11404481 10521505 18691976 19723038 20058876 14551213 10446219
MAPK3 POLR2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 12721286 14517250 14662762
MAPK3 MBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 10339476 16401070 1939237 1699809
MAPK3 ELK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 64.0 1.0 Omnipath 17145710 9130707 20506250 15547943 20371703 7618106 7601337 12697810 12473660 23331499 8007980 16291755 16393692 16998585 18988627 17255949 8208531 15014501 15187187 8586671 19541618 11145955 25241761 19565474 11309409 8887554 17052211 15277685 18334532 15782123 8548291 14499342 9927426 7889942 8262053 8386592 10716983 12665513 15967991 8477450 12947314 15212693 11274345
MAPK3 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 10781582 11239457 10958792 28937686 9467949 10348343 24194938 9739174 16713569 12955074 10747897 17237827 25767119 18523266 12393879
MAPK3 TWIST1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 21502402 18775330 8226933 9604935 8388392
MAPK3 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 10197981 9335504
MAPK3 ETS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 8761310 23331499 12048211 11948414
MAPK3 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 10949034 18372406 15461668 9528769 12118371 14680484 17615152 15059947 16076840 7491495 12093745 15212693 15528270 7838153
MAPK3 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 27342992 23405013 18411303
MAPK3 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 28115363 12801888
MAPK3 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 23331499 10197981 15241418 24080014 18775330 8226933 16156666 9604935 12193595 8388392
MAPK3 TAL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 19651622 23331499 11904294 8423803
MAPK3 MED1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12356758 16314496
AKT1 MDM2 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11154281 11715018 11923280 15169778 17680028 20214616 20398329
TWIST1 MDM2 â—¼   UP_REGULATES ✅ + 37.0 1.0 ACSN 11283614 11528470 12490555 13130303 14623871 15140942 15574337 15640618 15980428 16510505 16716598 16831886 17055429 17093497 17332325 17537911 17550342 17987801 18297062 18832382 19208835 19284610 19336515 20027199 20713526 20731704 20818389 21199805 21317430 21502402 21733352 2191300 21919891 22406545 22945800 7768934 9278421
TP53 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 201.0 1.0 Omnipath 23150757 20948295 10871862 10914734 21422812 21957016 14532965 22290440 20663877 20547751 11591713 24339722 11840331 22223137 16492744 15843377 22948151 7888679 20156675 21217645 22180176 8319905 9707425 15831521 17690113 9649502 10688649 9194564 15917661 15090541 20837136 8187772 10788589 17907153 15192123 8440237 11964305 16510138 10856296 15580300 7624148 12208736 21211512 16624812 17848574 11245471 21637567 20588255 10562557 9525742 9270029 16479015 19941079 14602726 15024021 18814047 20036872 10718212 18852133 12374749 18397889 25016801 12755686 22081073 22245141 23365201 8957072 22197810 15856024 20703075 23483203 9645455 19648117 20331637 22301280 14743206 23982177 9486848 15734740 19638633 19671680 17310983 10469568 20659896 10072445 21097889 17237821 11748232 11085543 21750655 16337599 21295542 1614537 9815889 9070662 16585169 9472631 17936559 17139261 11328884 12887889 20858413 9858609 14610316 20080970 19505873 11313463 15684615 18359851 18783169 16202543 9267820 12235242 14990790 15851483 7587074 18336191 21478269 17043642 15361831 18025460 23612020 10208414 11756653 24389645 9071998 9430645 9400998 9371494 23149414 22532570 9271120 10777217 22383580 18781178 12606552 14514686 17318220 11127813 16571800 19085961 9207798 10891494 10065155 11593391 14570892 12902982 19649205 20124454 17390010 19955655 12138177 19663772 23581014 15908423 10321740 23150759 19837670 10348346 18632610 9294611 11956627 12750288 12851404 8313378 9135153 15735665 7958853 8247544 9535786 16501602 18566224 8910340 11046142 9405685 7936649 12173040 17329361 21451571 14704432 23874713 18333294 19541936 22787160 18585004 22085928 12080472 7651818 11179471 10949923 19428175 15592502 8413278 11714701 10566557 18583933 9681831 15550242 15007388 19590512
ESR1 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12897156 17166846 12750288 8324731 22787161 21169420 19578757
TWIST1 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19336515 15140942 15545268 15574337 15640618
NCL MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 24147044 16751805 22103682 20195357
AKT1 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 60.0 1.0 Omnipath 11756412 11923280 20856200 20452955 20398329 18332867 19664995 10217147 11154281 19216069 20214616 11463845 19166854 15527798 9829964 17570479 16680151 17646672 12145204 15169778 15140942 25241761 11715018 25209720 17680028 21930127 11504915 29311840 15574337 23397142
MDM2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 559.0 1.0 Omnipath 20657550 30005830 17616658 9529249 10321734 33650658 9724739 24462112 24621507 15933712 23826318 24667498 22948151 22653443 23776060 25313037 25241761 19303885 16857591 23246961 19033382 20591651 21149449 25417702 15122315 16579792 27543608 29670376 12208736 17848574 26673821 25277184 23443559 23318437 21060154 15210108 19805293 8875929 8058315 21471462 17879958 25362358 23169665 22301280 21584881 20124408 10980696 26876197 17310983 17380154 15058298 24567357 18665269 30109812 25637791 18467333 22337874 22227409 22389628 15242646 22510990 15950904 15001357 19483087 26540344 14559824 21986495 26556313 20708156 19901969 33765973 32528731 11562347 10202144 22374672 10722742 22083959 21965653 17098746 19234109 30679555 16107876 12690203 22525275 19071110 28542145 12620407 20837658 27129163 9131587 24240685 27031960 10681559 19305137 11744695 19188367 16023600 24659749 17347673 12944468 20395212 22084066 20639885 21454483 12897156 16432196 10347217 10706102 11178989 20174603 16751805 15542844 12842086 11431470 11384992 25739118 15064742 23402884 27462439 16905769 22124327 27215386 12867035 22588298 27336364 14702041 16152627 23776465 22262183 21132010 19411846 18309296 23483203 11709713 18981217 14612427 22920093 23671280 24980433 27905468 25168242 21750659 26238070 22737255 23609977 27282385 20847049 20705607 21075307 28082682 17297477 11697899 17936559 24361594 19098711 15469934 34591612 24998844 16212962 11094089 12915590 17116689 11713288 15144954 23201157 10608892 17591690 25156994 17301054 22444248 26883110 26001071 19160491 22157679 24413661 19357310 23802716 15280377 21317885 11597128 19579266 25624478 18061646 21088494 9223638 10435614 31177307 11331603 22391559 20570896 19941302 9278461 18485870 15604276 18566590 12612087 11046142 14704432 26186194 10935507 16173922 14596917 17159902 25543083 19656744 15848166 18316739 22266868 17056014 19255450 21561866 19590512 11839577 22991965 22266850 24200963 11285227 11713287 22975381 19081178 20660730 26475964 16678796 23261415 20173098 17666403 25464845 32427887 23252402 17438265 20959462 22659184 17470788 22912717 17080083 15247280 19332559 17989425 16870621 18813780 20235143 11278372 10562557 25609649 10561590 19411066 17908790 19568783 7926727 21925390 21988832 24127580 18604177 14499615 17371838 17525743 33061576 21887275 26578655 21084564 16861890 20694676 12552135 22914926 17363365 24643130 1614537 22916255 12381304 34992144 12167711 19857530 15053879 10889512 11486026 22103682 16713569 17110336 17426254 10640350 21316347 21478269 15154850 12529318 16595680 16414131 19597489 23880345 27893708 7686617 27811966 17318220 29997244 27308622 19166840 35044719 16159876 24314634 15313915 25283148 22032989 24926618 18172499 19837670 16215989 23134341 26908445 9824166 18451149 21170087 23572512 21465263 22807444 15013777 16845383 10488081 23946421 11714701 25384516 22474335 25312347 23370271 23150757 18541670 22318540 11925449 21572037 24488098 32066565 17268548 20542919 11572869 16338390 21857681 23150668 19223463 20234175 20484049 11070080 20591429 22575647 11351297 16624812 22411991 20588255 17369817 11223036 15908921 9582019 25103245 17302414 21071676 9450543 31968249 34562520 18332869 14671306 21084285 27856536 30464405 26882543 21726810 33020477 21261729 21268072 12426395 16964247 20659896 19106616 22331460 23728348 10827196 22524527 21098709 9363941 17139261 20080206 14517261 22487680 31652301 17290220 27106262 16866370 24207125 28223335 9271120 15550400 7689721 26350565 10196247 27807478 10766163 15558054 35371302 26203195 29487367 25512388 25954860 18223694 15824742 24842904 14741215 16055726 22085928 32894144 18234963 17875722 18815136 15295102 15308643 15358376 22819825 15094782
MDM2 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 17974989 26411689 27835608 26973243 15640443 12145204
MEN1 KMT2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 17145710 15199122 19075677 16618927 17671196 22936661 22327296 15640349 16997566 20818375 20961854
MEN1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 11526476 14508515 16713569
GTF2F1 METTL3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 9409616 24316715 24407421 24981863
NCBP2 METTL3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 9409616 24316715 24407421 24981863
GTF2F2 METTL3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 9409616 24316715 24407421 24981863
NCBP1 METTL3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 9409616 24316715 24407421 24981863
NPM1 SKP1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 22955283 31434245 16009132 12748172
NPM1 CUL1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 22955283 31434245 16009132 12748172
NPM1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 23443559 15144954 16740634 15310764 16376884 12080348
PRKCD TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17906639 16314418 16377624
PRKCD IL6ST â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12361954
PRKCD STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 76.0 1.0 Omnipath 8272872 19413330 11335711 15677447 9343414 15465816 8140422 12576423 11350938 7678052 20068231 12754507 9880505 12763138 9872331 18491316 18669648 8662591 10521505 18691976 27036017 27458446 7537214 8626374 20058876 25280942 16951338 14551213 8164674 12754506 10446219 12361954 12754505 16418226
PRKCD GSK3A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 18691976 8524413 12054501 19413330 11749387 11884598 11035810
NOTCH1 SNW1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 17145710 23331499 10713164 11404076 15546612
PTPN6 STAT3 â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 12176909 12773515 12917349 15240681 15713798 22513334 22952938 25355530 26667266 27474009 8976179 8986721 9765283
STAT3 MMP9 â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10347215 11875494 12193690 12223527 12907458 14607900 14670306 15218058 15356132 15465827 15573129 16418395 17404308 18776941 19380816 20093776 20237412 20406969 20435894 20580461 20581311 21372296 21765015 21840487 22461508 23124025 23390297 23454751 23953057 24857661 27216177 28186502 7543512
STAT3 IL1B â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10347215 11875494 12193690 12223527 12907458 14607900 14670306 15218058 15356132 15465827 15573129 16418395 17404308 18776941 19380816 20093776 20237412 20406969 20435894 20580461 20581311 21372296 21765015 21840487 22461508 23124025 23390297 23454751 23953057 24857661 27216177 28186502 7543512
STAT3 CCL2 â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10347215 11875494 12193690 12223527 12907458 14607900 14670306 15218058 15356132 15465827 15573129 16418395 17404308 18776941 19380816 20093776 20237412 20406969 20435894 20580461 20581311 21372296 21765015 21840487 22461508 23124025 23390297 23454751 23953057 24857661 27216177 28186502 7543512
STAT3 CEBPB â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10347215 11875494 12193690 12223527 12907458 14607900 14670306 15218058 15356132 15465827 15573129 16418395 17404308 18776941 19380816 20093776 20237412 20406969 20435894 20580461 20581311 21372296 21765015 21840487 22461508 23124025 23390297 23454751 23953057 24857661 27216177 28186502 7543512
STAT3 TWIST1 â—¼   UP_REGULATES ✅ + 38.0 1.0 ACSN 10347215 11528470 12223527 13130303 14607900 14670306 15218058 15356132 15573129 15810077 16418395 16716598 16831886 17403902 18297062 18776941 18832382 19380816 19412634 20093776 20237412 20406969 20581311 21317430 21840487 21883379 22006115 22943793 22945800 23124025 23454751 23953057 24857661 27216177 28186502 7543512 7768934 9278421
STAT3 CCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 24429361 19741199 17710228 19736311 12488502 20493732 19404962
STAT3 TWIST1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23161342 17909010 24491388 23623921 23492367
TRIM28 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 18381204 18037959
IL6ST STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 12040451 12361954 8272872 18060032
HCK STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 58.0 1.0 Omnipath 19901323 10918587 9305919 8272872 9344858 12626508 10815799 16497976 15592455 17389395 12576423 11350938 9484840 11294897 12244095 11404481 9083098 8626374 9566874 11940572 11429593 14551213 11850821 17016520 9582023
FGFR4 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 54.0 1.0 Omnipath 19901323 10918587 9305919 8272872 12626508 16497976 15592455 17389395 12576423 11350938 11294897 12244095 9083098 8626374 9566874 11940572 11429593 14551213 11850821 17016520 9582023
CEBPB STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11134330 18266962
STAT3 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19345327 12057007 23335796 16713569 18448488
STAT3 TWIST1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 21883379 25814554 22945800 22006115 18832382 16831886 18297062 19412634 21317430 23623921
SUPT5H NCBP2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 12653964 10757782 9857195 9450929
SUPT5H NCBP1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 12653964 10757782 9857195 9450929
SUPT5H CTDP1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 12653964 10757782 9857195 9450929
ESR1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 20080630 16115928 22787161 12750288 20696891 17681750 17699779
RELA TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 18269916 10348347 11032029 8051093 20061391 15155458 21332394 9890939 21887328
ETS1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12145208 19022222 8649821 10510472
CEBPB TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19135161 23564453 19075931 24333671
TP53 PTK2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 24809783 20515733 21355845 21071137 21269258 18493017 17999388 17725966
TP53 HSP90AB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15052775 15284248 21478269
TP53 MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17311279 15899818 17077165 18635530
TP53 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17202838 18084622 18945670 11504717
TP53 FGFR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22466965 18811981 16557594 24492005
TP53 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12485897 18661553 19763735
MED1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 15848166 9444950 16713569 11118038
CSNK2A1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 53.0 1.0 Omnipath 23443559 15358769 9315650 19413330 11285227 11551930 11883897 22975381 11709713 16083285 1088347 33745968 16552184 10884347 10747897 10673501 7936649 12628923 25241761 21127074 16964247 24725084 10606744 10348343 10951572
CSNK2B TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 10606744 11709713 10214938 10951572 16713569 11551930 10747897 10673501 11883897
RCHY1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 21988832 19483087 17568776 24367557 25116336 21084285 12654245 21791603 20452352 19043414 16713569 31630802 27519799 19918835
PPP1CC TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 17145710 17274640 15178317 16501611
TP53 HSP90AB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 23443559 18431400 11707401 22939624
TP53 PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 18431400 25241761 15855171 18206965 19857493
SMAD4 TWIST1 â—¼   UP_REGULATES ✅ + 31.0 1.0 ACSN 11074002 11279127 11792802 12490555 12702545 12809600 14623871 15265520 16510505 16617148 16713975 16831886 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18832382 19208835 19412634 20731704 21199805 21317430 21614932 21883379 22006115 22406545 22945800 9389648
CSNK2A1 TWIST1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21559372
AKT1 TWIST1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 25847239 26759241 29314610 27623213 20400976 28099910
TWIST1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 34881782 12553906
BARD1 XRCC3 â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
BARD1 XRCC3 â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
RELA CCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 60.0 1.0 Omnipath 24337575 10644332 22189654 18226221 20038977 8630731 12488502 19738286 22189669 14976218 19371341 12540607 24260304 11716760 21138578 8617886 12218154 14631383 20952659 17452470 16325549 10744656 15223809 10530453 11006087 16040075 16730843 23583295 24063814 27076634 10987310 16206198 9388261 10614622 18353872 16166627 16829531 16818736 10636866 20195282 10469356 17507908 12647268 12682245 21106671 24550391 16764699 17932106 25108845 20200316 15950427 24634218 9174597 23198981 11949945 9916692 17537731 22723832
CEBPB CCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17180354 10748205 20019816 12145301 16784777 17390372 18649942 20730378 19026986 15710476
CSNK2A1 CSNK2B â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
CSNK2B CTDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 12591939 19664994 19664995 18669648 15302935
PTBP1 NCBP1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 10982855 9858549 1906035 9271388
SUPT4H1 NCBP1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 12653964 10757782 9857195 9450929
RNF40 RNF20 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21362549 16307923 19410543
RNF20 RNF40 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21362549 16307923 19410543
CSNK2A1 CDC34 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 11546811 12037680 16123592
POLR2C POLR2J â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
SMAD3 SMAD4 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
SMAD2 SMAD4 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
SMAD4 SMAD3 â—¼   PHYSICAL_INTERACTION 72.0 1.0 ACSN 10454538 10925299 10964912 11007770 11013125 11013220 11074002 11114293 11224571 11279127 11283613 11283614 11376132 11399519 11792802 11875494 12193690 12545156 12702545 12809600 14976548 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 16831886 17018611 17055429 17260466 17550342 17563753 17689680 17705132 18353785 18768831 18832382 19208835 19597490 19815509 19901969 20027199 20713526 20731704 21041997 21042762 21098712 21252118 21317430 21577210 21614932 2191300 22331441 22514743 22652804 23140366 23338822 23390297 23784029 23869868 25374926 6357187 8515656 8871614 8893010 9312026 9389648 9618481 9670020
SMAD4 SMAD2 â—¼   PHYSICAL_INTERACTION 52.0 1.0 ACSN 10454538 10925299 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11399519 11792802 11875494 12193690 12545156 12702545 12809600 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 17055429 17260466 17550342 17689680 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23390297 23784029 23869868 6357187 8515656 8871614 9312026 9389648 9618481 9670020
SMAD4 SMAD3 â—¼   PROTEIN_INTERACTION 72.0 1.0 ACSN 10454538 10925299 10964912 11007770 11013125 11013220 11074002 11114293 11224571 11279127 11283613 11283614 11376132 11399519 11792802 11875494 12193690 12545156 12702545 12809600 14976548 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 16831886 17018611 17055429 17260466 17550342 17563753 17689680 17705132 18353785 18768831 18832382 19208835 19597490 19815509 19901969 20027199 20713526 20731704 21041997 21042762 21098712 21252118 21317430 21577210 21614932 2191300 22331441 22514743 22652804 23140366 23338822 23390297 23784029 23869868 25374926 6357187 8515656 8871614 8893010 9312026 9389648 9618481 9670020
SMAD4 SMAD2 â—¼   PROTEIN_INTERACTION 52.0 1.0 ACSN 10454538 10925299 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11399519 11792802 11875494 12193690 12545156 12702545 12809600 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 17055429 17260466 17550342 17689680 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23390297 23784029 23869868 6357187 8515656 8871614 9312026 9389648 9618481 9670020
SMAD4 ETS1 â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 8515656 9389648
SMAD4 SMAD3 â—¼   LOCALISATION ✅ 72.0 1.0 ACSN 10454538 10925299 10964912 11007770 11013125 11013220 11074002 11114293 11224571 11279127 11283613 11283614 11376132 11399519 11792802 11875494 12193690 12545156 12702545 12809600 14976548 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 16831886 17018611 17055429 17260466 17550342 17563753 17689680 17705132 18353785 18768831 18832382 19208835 19597490 19815509 19901969 20027199 20713526 20731704 21041997 21042762 21098712 21252118 21317430 21577210 21614932 2191300 22331441 22514743 22652804 23140366 23338822 23390297 23784029 23869868 25374926 6357187 8515656 8871614 8893010 9312026 9389648 9618481 9670020
SMAD2 SMAD4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16052471 11376804 11456453 9812998
SMAD3 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 104.0 1.0 Omnipath 25609649 9843571 15084259 20211142 21532621 24584437 18729074 23788427 12419246 18923419 9892009 19768112 10531362 15231748 9679060 12167862 21988832 12150994 23331499 12543979 18568018 21071413 19135894 15467747 25502805 9732876 11927552 16189514 12917407 25514493 15350224 10995777 18988627 10092624 12732634 25910212 10878024 9111321 20564330 27107012 9311995 12957874 20142324 11114293 32296183 15588252 15761153 24157709 26555259 29892012 17469184 22442258 16714330 21597466 15922743 22045334 17591701 24382352 22310290 19139564 19917253 29997244 31515488 28115363 10942775 21297662 17283070 12794086
SMAD2 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 110.0 1.0 Omnipath 15613484 17145710 25609649 15817471 20211142 21532621 24584437 18729074 23788427 12419246 16916642 9288972 9892009 21454478 17510063 10531362 15231748 11027280 12167862 21988832 9389648 23331499 12543979 18568018 21071413 19135894 18511908 15467747 12808092 11927552 25514493 15350224 18988627 12732634 10878024 9111321 9311995 9346908 10199400 11264182 12957874 11114293 15761153 11274206 12621041 17272273 24157709 26555259 12374795 22442258 10781087 15922743 11102446 17591701 18783722 16751102 19139564 19917253 9346966 21297662 17283070 12794086
SMAD1 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 34.0 1.0 Omnipath 17183365 9436979 24412244 11779505 31467278 21454478 10531362 15231748 12167862 23331499 21071413 11700304 12874272 16189514 18988627 20957627 9111321 15761153 32296183 26555259 14701756 14534577
TRIM33 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 15820681 19135894 21597466 24307592
RELA TRAF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15041463 19392652 21573233 15723831 9733516
NCOR1 SMAD2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 10549282 10485843 10535941 10531062 11389444
SMAD3 SMAD2 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10454538 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23869868 8515656 9312026 9389648 9618481 9670020 9865696
SMAD3 SMAD2 â—¼   PROTEIN_INTERACTION 41.0 1.0 ACSN 10454538 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23869868 8515656 9312026 9389648 9618481 9670020 9865696
PPM1A SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 18988627 16751101 23331499
TRIM33 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 16751102 19135894 18003620
SMAD2 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 21988832 26186194 12543979 9111321 15084259 9311995 25878769 18729074 12700238
NCOR1 SMAD3 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 10549282 10485843 10535941 10531062 11389444
SMAD3 ETS1 â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 8515656 9389648
CUL1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11359933
TRIM33 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16751102 23331499 18003620
PPM1A SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 18988627 16751101 23331499
AKT1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 25241761 15104092 16362038 21071413 18988627 26297431 15048128
CDK8 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 19914168 19914161
SMAD3 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11555647 23331499
SMAD3 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 23331499 16713569 14638857 18988627
SMAD3 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 23331499 11248024 11280774 12226080 16713569 11707452
AKT1 MMP9 â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 17409395 17680028 18471976 19440036 19930715 19945467 20214616 20398329 20609352 21084277 22131018 23572150 23589069 24030100 25136802 26597054 27328425 27510662 27572739 29556339
ETS1 MMP9 â—¼   UP_REGULATES ✅ + 27.0 1.0 ACSN 10048576 15001984 15003528 15111329 15181457 16079281 16391805 16556862 16682805 17615296 17872466 18337545 19208835 19564415 20589835 21041997 21081489 21317430 22439866 22608498 23691193 24376839 7512751 7528107 8844971 9157999 9811054
ETS1 MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 22270366 15949416 16722933 11556732 22206665 10949659
RELA MMP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 48.0 1.0 Omnipath 18298869 12105194 11376631 14600595 17673602 23423566 17922642 15605368 14755547 20332461 18357389 21502320 17186550 11060311 18566231 9679762 16554298 16687076 17121934 15086314 18843978 21963718 18056465 20103608 21238464 17174275 15536164 18028425 17158602 17590163 19303700 7860222 19539355 9500201 22587999 19783786 18567920 15175338 17498959 19616091 10359016 18801463 19454280 24755270 19662350 12193473 16014933
ETS1 MMP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10048576 16391805 17615296 15111329 19564415 9157999 16079281 21081489 21041997 15181457
NOTCH1 SKP1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11585921 15546612 11461910 18094723
NOTCH1 CUL1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11585921 15546612 11461910 18094723
NOTCH1 HES1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 10520600 11120788 10066785 16869730 12814948 7566092 21956839 9819428 10933396 11866432 20007915 10205173 11741889 19165418 15546612
MAML1 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 23022380 16530044 11101851 19907488 22100894 21820430 12644465 16713569 12370315 11997524 18427106 11390662
NOTCH1 HES1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23343194 19000719 18495817 16039586 19619488 17143292
AR NCOR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 15598662 11971970 16469706 14593076 15256534 23518348 16713569 12089345 16914745 20812024 20974212
NCOR1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 16469706 12738788 12145334 17400812 16713569 21182203
HES1 CDKN1C â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19541765 22705236 25005473 16899237
RELA CUL1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9990852 10514433 9859996 9990853 7628694
CUL1 SKP2 â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 11516665 11900249 12648680 12820959 15071497 15147722 15340381 15459660 15668399 15688063 15703371 16697054 17884153 18931676 19270156 19622404 19686080 19809470 19847258
CUL1 SKP1 â—¼   PHYSICAL_INTERACTION 26.0 1.0 ACSN 11516665 11900249 12648680 12820959 14536078 15071497 15147722 15340381 15459660 15489953 15668399 15688063 15703371 16697054 17053147 17884153 18636226 18787170 18931676 19150432 19270156 19622404 19686080 19797085 19809470 19847258
CUL1 SKP1 â—¼   PROTEIN_INTERACTION 1.0 1.0 HIPPIE 14685242 16189514 17290223 20832730 12504025 12904573 10230407 19933270 23324393 12504026 9636170 26540345 12609982 27697867 26753747 21145461 22474075 28007894 18818696 9736735 9990852 22767593 28152074 10023660 29070679 9827542 23951410 16357137 16759355 10713156 15452136 19270694 11027288 26474281 23770852 10648623 29499133 21249194 34499862 12628165 15966899 21169563 22660580 11961546 9430629 32313199 29863914 10230406 30653357 19945379 9663463 21778237 34237211 18094045 26976582 27705803 32249768 29103612 33961781 12684064 26725323
CUL1 SKP2 â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 11516665 11900249 12648680 12820959 15071497 15147722 15340381 15459660 15668399 15688063 15703371 16697054 17884153 18931676 19270156 19622404 19686080 19809470 19847258
CUL1 SKP1 â—¼   SHARES_COMPLEX 26.0 1.0 ACSN 11516665 11900249 12648680 12820959 14536078 15071497 15147722 15340381 15459660 15489953 15668399 15688063 15703371 16697054 17053147 17884153 18636226 18787170 18931676 19150432 19270156 19622404 19686080 19797085 19809470 19847258
AKT1 CUL1 â—¼   ENZYMATIC_REACTION ✅ 45.0 1.0 ACSN 10722653 10949026 11274345 11715018 11756412 11756498 11923280 12408816 12906785 15169778 15808505 16469695 16697215 17052453 17461779 17680028 18000759 18372248 18492954 18570873 18636226 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20138985 20214616 20338997 20398329 20832730 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9812896
AKT1 CUL1 â—¼   DOWN_REGULATES ✅ - 45.0 1.0 ACSN 10722653 10949026 11274345 11715018 11756412 11756498 11923280 12408816 12906785 15169778 15808505 16469695 16697215 17052453 17461779 17680028 18000759 18372248 18492954 18570873 18636226 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20138985 20214616 20338997 20398329 20832730 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9812896
SKP1 CUL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 66.0 1.0 Omnipath 9663463 19945379 12684064 19270694 16759355 23951410 10648623 11961546 26540345 26976582 26474281 17290223 9736735 21169563 14685242 16357137 21145461 29070679 15452136 15966899 12628165 21778237 22474075 16189514 22767593 11359933 9430629 10713156 10023660 10228155 12504026 18818696 9827542 12504025 18094045 10066435 23324393 23770852 9990852 12417738 27705803 9636170 21249194 12904573 34499862 11027288 26725323 20832730 19933270 12609982 10230407
SKP1 RELA â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9990852 10514433 9859996 9990853 7628694
SKP1 SKP2 â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 11516665 11900249 12648680 12820959 15071497 15147722 15340381 15459660 15668399 15688063 15703371 16697054 17884153 18931676 19270156 19622404 19686080 19809470 19847258
SKP1 SKP2 â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 11516665 11900249 12648680 12820959 15071497 15147722 15340381 15459660 15668399 15688063 15703371 16697054 17884153 18931676 19270156 19622404 19686080 19809470 19847258
CEBPB PPARGC1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23564453 19491401 18467525 24353183
AKT1 PPARGC1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17554339
PRKACA RELA â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17462920 12628924 19197368 19122653 18385332
RELA AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 24466341 16619263 14576180 15517885 14715080
RELA AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20186924 18031796 20649564
RELA IL1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 48.0 1.0 Omnipath 26596471 27338466 11114294 8413223 20975042 17707233 23383347 11058167 12686724 16433741 23667107 15382119 19122653 24009751 27211851 18566416 15292915 20617571 23056550 12517972 18285351 19843519 22267743 15812237 25161822 22388040 8021507 9878621 14960579 10963848 23195252 11395507 27534992 9058643 15543947 19846753 20696864 8679226 24908318 28389361 27371733 15972680 20336759 10080875 17082635
CSNK2A1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 34049972 15016307 10938077 27630163
PRKACA RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 11931769 15833743 9150141 17959673 9660950 16135789 12628924
IL1B RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 25606026 26999213 22240205 23666959 19197368 25306394 24009751
AKT1 SKP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23807222 28446188 22733130 19270695 20160512 19549334 21963805
CDK8 MED12 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 11001584 12417340 15279786 15337521 16007092 16413481 17000779 17303408 17565603 17660363 18590585 19879327 20144767 21327159 21330129 7575488 9216996
CDK8 MED12 â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 11001584 12417340 15279786 15337521 16007092 16413481 17000779 17303408 17565603 17660363 18590585 19879327 20144767 21327159 21330129 7575488 9216996
CDK8 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 19914168 19914161
MAPK7 ETS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 8761310 12048211 20361728 25885538 8552081 11948414
CEBPB IL1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 21917825 12072435 9372929 16867259 20702408 17283046 10464291 16569740 10801783 15812237 22260630 10841183 10838190 10383163 9376596 17386941 10956548 12759449 11278846 12468538 11035101 11801594 2112087 12355443 15383601 16439360 19806478 22074460 16399630
KMT2A FGFR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23629655 20861184 19212323 22046413 23691099 24244196
ESR1 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11029009 15569929 18450422 20664923 15496458
AR AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 20589722 11278645 17896924 18687691 22740037 12621049 12063252 22970326
CSNK2A1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 29732088 17374729 21506126 11689703 10671551 12149249 15818404 10747897 10837139 20976471 19662498 21285348 11035045 11707428 21735093 17444818 20558317 11972058 16707567
AKT1 PRKACA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 20016067 23331499 17680028 20214616 17688959 20398329 16537363 17052453 19575820
AKT1 TAL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 19406989 15930267
AKT1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 18521086 26944939 11108261 17627277 20101208 17570479 15604293 23169992 26554417 16452229 15193262 7838153 12374744 11139588 26272591 11432835 20179234 11507039 9528769
AKT1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 17470458 18349820 29861848 16210317 21601007 17570479 11404460 22155408 12621049 14555644 11156376
AKT1 CDKN1C â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12925736 23421998
AKT1 GSK3A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 110.0 1.0 Omnipath 15772344 19797085 23549785 20371716 11884598 25584893 11583116 11520785 14550568 19920184 15710331 21530327 9065430 16188907 24632852 12515807 11289110 24879152 20110348 12890758 15333638 14633703 11803463 16123357 8524413 21868755 12054501 23142783 25714023 16585200 15808505 22497526 16767165 19117997 14744935 19443725 21118801 18691976 18209096 11563975 17192257 11085518 19369195 19043530 11896604 10716737 19914182 19996208 21441927 32645325 15805282 21464307 34381779 16223362 12181443 15755769 11331582 11035810 21445305 27331409 16987514 11340086 15723049 22499768 18701488 11749387 20686112 11509608 19413330 20233866 15950778 20708687 14660586 17386267 11577096 15371448 11956225 12649200 16476742 11254732 21575859 14988390 11779850 19574224 20739666 17200115
HCK PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 11369622 12590707 23109003 15728464 9148935 12495636 10753828 25814554 7529876 10593973
ESR1 CEBPB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19652226 18414489
PPM1A SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16931515 23331499
AR PRKACA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12933667 10075669 9886819 15691881
PRKACA ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 22266331 9891036 15193262
PRKACA PTBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 12851456 18669648
PRKACA GSK3A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 18691976 8524413 12054501 19413330 11749387 11884598 11035810
PRKACA TAL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 22310283
CSNK2A1 TERF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18347021
CSNK2A1 CTDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 12591939 19664994 19215094 19664995 15723518 18669648 15302935
CSNK2A1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 11139588 26703694 9337862 20043841 11432835 11507039 9528769 7838153
CSNK2A1 HSP90AB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 15822905 17081983 16565220 18088087 29854279 2492519 34359868 25995454 1956339 16094384 15581363 18591256 16964243 92065884 15302935
ESR1 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8299561 11000528 22391641
AR ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 12389206 11032808 16713569 11000528 18988627
DDX17 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 19995069 21182205 12738788 20348541 19718048 20663877 25604459
ESR1 NCOA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 18499756 9192892 9430642 11014206 19460354 15657427 23331499 11477071 26487511 16645043 12612084 20348541 12630920 14766010 17697320 11937504 12714702 12554772 9774463
AR CDKL5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20610535
AR MED1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17483314 21593191 24778216 23887938
NCOA2 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 9717843 12588987 15684378 14593076 24239470 15563469 18780293 12810069 16713569 10601285 14966121 10935543 10454556
RCHY1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 12200228 16713569 27903893 17721809 16914734
PTBP1 NCBP2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 10982855 9858549 1906035 9271388
NCBP2 SUPT4H1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 12653964 10757782 9857195 9450929
POLR2B POLR2E â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
POLR2A POLR2E â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
POLR2C POLR2E â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
POLR2E POLR2G â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
GTF2F2 PTBP1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 10982855 9858549 1906035 9271388
GTF2F2 GTF2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 7854423 11278533 31467278 11183778 8441635 16189514 8662660 7827505
POLR2A POLR2F â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
POLR2C POLR2F â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
POLR2F POLR2G â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
PTBP1 GTF2F1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 10982855 9858549 1906035 9271388
GTF2F1 CTDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12732728 12591939 9765293
SUPT4H1 CTDP1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 12653964 10757782 9857195 9450929
POLR2A POLR2L â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
POLR2G POLR2L â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
POLR2B POLR2L â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
POLR2C POLR2L â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
POLR2A POLR2K â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
POLR2B POLR2K â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
POLR2C POLR2K â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
POLR2A POLR2C â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
POLR2B POLR2C â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
POLR2C POLR2G â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
POLR2A POLR2G â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
CDK12 POLR2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 52.0 1.0 Omnipath 12721286 10995388 21596787 21964340 17157258 22053051 21159777 22509028 16672643 18593926 20434984 16314842 25470060 26588990 27058666 20880846 17686863 22012619 23249733 11425311 10886368 14662762 22020438 18757415 17956865 26593720 11683387 20106982 15125840 16641292 10958691 20550933 26700805 26279188 30587525 21536667 27099314 27068475 14517250 25620562 28646117 20471949 21070967 17259211 25910208 26527278 22195966 20837538 16735508