Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
Graph tools:

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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
PIAS4 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21113239
ITCH CBL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12226085 5215735
CBL FGFR3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
BUB3 CDK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11285280 10679238
MAPK1 CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17205132
GSN CDK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
FGFR3 CDK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
GRIN2C CDK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
NBN CDK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 25558984 22231403
RNF7 CUL5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8153045 21516116
TP53 DDB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11971958
PCNA FANCL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20937699
SKP1 FBXW7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 21620836 8177582
FBXW7 SHPRH â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
SKP1 FZR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12791267 10023660
FZR1 BTRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12791267 10023660
ANAPC4 FZR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
CDC23 FZR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
ANAPC10 FZR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
ANAPC5 FZR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
ANAPC1 FZR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
FZR1 ANAPC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
FZR1 CDC23 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
FZR1 ANAPC10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
FZR1 ANAPC5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
FZR1 ANAPC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
GSN UBE2A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
UBE2N HLTF â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18719106 0805685105
HLTF UBE2B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18316726 0800563105
HSP90AA1 MAP3K1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
MAPK1 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15778365
PML MDM2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216620 12915590
UBE2I MDM2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12393906 20972456
SUMO1 MDM2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12393906 20972456
MDM2 PML â—¼   COLOCALIZATION 2.0 0.8 intact 5216620 12915590
SUMO1 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12393906 11384992
NBN UBE2I â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20023648 22508508
NBN SUMO1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20023648 22508508
UBC NEDD4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7104155 19343052
SUMO1 PIAS4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20023648 22508508
ZNF512B PIAS4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
UBE2I PIAS4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20023648 22508508
PIAS4 UBE2K â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
TP53 PML â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216620 12915590
SUMO1 PML â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17036045 5219211
PSMD3 TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
RBX1 BTRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15082796 17183061
UBE2L3 STUB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TP53 STUB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21478269 17666403
TP53 SUMO1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11420669 21187340
SUMO1 CTBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12769861 12679040
BMX TP53 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217965 16186805
TP53 BTRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19196987 0812256106
TP53 CASP6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SAE1 TP53 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 intact 15327968 5217177
TP53 CDC20 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19273532 17873905
TP53 CD59 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11812190 12553064
TP53 GSK3B â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5216887 14744935
COP1 TP53 â—¼   UBIQUITINATION ✅ 2.0 0.8 intact 15103385 5217012
RCHY1 TP53 â—¼   COLOCALIZATION 2.0 0.8 intact 5220017 17568776
SYVN1 TP53 â—¼   COLOCALIZATION 2.0 0.8 intact 17170702 5219455
TP53 CDC20 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19273532
TP53 BIRC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16917513
TP53 PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7915517
UBB TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
MAP3K1 TRAF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9008162 10465784
UBQLN1 TRIM32 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
UBA1 WWP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
GRIN2C UBE2A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
EIF2S3 UBE2A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
FGFR3 UBE2A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
UBE2A CASP6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
UBE2A KLF11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
UBE2A OPTN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
UBE2A DNALI1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
UBE2A RAPGEF4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
UBE2A UBQLN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
UBE2A RAN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
UBE2A HMOX2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
UBE2A HSPA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
UBE2A NUP58 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
UBR1 UBE2B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
UBC UBE2B â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 intact 5211616 10388568
UBE2N UBE2I â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22661230 22635276
XIAP CASP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9545235 15200957
ELOC CUL2 â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 5219492 17183367
CUL2 ELOC â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 19327355 7014028
UBE2M CUL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17439941
UBE2D1 UBB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22842904 21857666
CASP6 EIF3F â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
NUP58 EIF3F â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
UBC EIF3F â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6613251 18354498
EIF3F DNALI1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
EIF3F KLF11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
WWP2 PSMF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
PSMF1 WWP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
PSMF1 HSPA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CDC23 OPTN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8153045 21516116
OPTN RETREG3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RPS27A PRKN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 26161729 24856362
UBB MAP3K1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
RNF7 CDC34 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10851089 16874460
SMURF2 TGFBR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22298955 15221015
PLAU PLAT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7721771 16189514
SKP1 CDC20 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12791267 10023660
CDC20 BTRC â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12791267 10023660
CDC20 CDC16 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12196507 9628895
CDC20 ANAPC7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10318877 12956947
CUL1 UBE2M â—¼   NEDDYLATION ✅ 2.0 0.8 intact 17914462 6175264
BTRC SKP1 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
SKP2 SKP1 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
MAP3K1 UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218828 16845370
GSK3B MAP3K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12584189
CBLB FGFR3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
UBE2K CBLC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ITCH CBLC â—¼   COLOCALIZATION 2.0 0.8 intact 12226085 5215735
CBLC FGFR3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17635922 10514377
PLG PLAT â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 2318848 7199524
PLG PLAT â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 2496749 2962641
PLAT PLG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11928826 1447176
UBC SMURF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7104155 19343052
ZNF512B VHL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
BIRC3 BIRC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23070005 18485876
ATXN10 PIAS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
WWP1 UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7104155 19343052
WWP2 UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7104155 19343052
UBC RCHY1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5220017 17568776
PRKN UBE2L3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8214014 21694720
ANAPC7 CDC27 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10922056 10500174
ANAPC1 CDC27 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
CDC27 ANAPC7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10922056 10500174
CDC27 ANAPC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
CDC16 ANAPC5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
ANAPC2 ANAPC5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
ANAPC1 ANAPC5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
ANAPC10 ANAPC5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
ANAPC4 ANAPC5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
CDC23 ANAPC5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
ANAPC5 CDC23 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
ANAPC5 ANAPC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
ANAPC5 ANAPC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
ANAPC5 CDC16 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
ANAPC5 ANAPC10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
ANAPC5 ANAPC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
CDC16 ANAPC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
ANAPC10 ANAPC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
ANAPC4 ANAPC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
ANAPC1 ANAPC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
CDC23 ANAPC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
ANAPC7 ANAPC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10922056 10500174
ANAPC2 ANAPC10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
ANAPC2 ANAPC7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10922056 10500174
ANAPC2 ANAPC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
ANAPC2 CDC16 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
ANAPC2 ANAPC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
ANAPC2 CDC23 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
ANAPC4 ANAPC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
CDC23 ANAPC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
ANAPC10 ANAPC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
CDC16 ANAPC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
ANAPC1 ANAPC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
ANAPC1 CDC23 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
ANAPC1 CDC16 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
ANAPC1 ANAPC10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
ANAPC4 CDC16 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
ANAPC7 CDC16 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10318877 10500174
CDC16 ANAPC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
CDC16 ANAPC7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10318877 10500174
KLF11 CDC23 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TRIM27 CDC23 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8153045 21516116
CASP6 CDC23 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ATXN10 CDC23 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ANAPC4 CDC23 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
CDC23 ANAPC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
ANAPC10 ANAPC7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10318877 10500174
ANAPC7 ANAPC10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10318877 10500174
ANAPC10 ANAPC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
ANAPC4 ANAPC10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10500174
PRKN HSPA1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20418918
UBE2K BIRC7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TRIM27 UBE2K â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
ZMYM2 ZNF512B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
ATXN10 WDR61 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
STUB1 UBE2D4 â—¼   PHYSICAL_INTERACTION 802.0 0.8 STRING 36370105
RBX1 UBB â—¼   PHYSICAL_INTERACTION 804.0 0.8 STRING 36370105
RBX1 RPS27A â—¼   PHYSICAL_INTERACTION 804.0 0.8 STRING 36370105
RBX1 UBC â—¼   PHYSICAL_INTERACTION 804.0 0.8 STRING 36370105
RAN UBE2I â—¼   PHYSICAL_INTERACTION 804.0 0.8 STRING 36370105
BTRC RPS27A â—¼   PHYSICAL_INTERACTION 804.0 0.8 STRING 36370105
UBA3 UBE2F â—¼   PHYSICAL_INTERACTION 804.0 0.8 STRING 36370105
RBX1 UBE2G1 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
CBLB UBB â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
MDM2 CDKN2A â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 7989562 20713054
HUWE1 PCNA â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 25147182 22203964 27146073
UBE2K MDM2 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 23933584 21965653 15280377 30017913
PIAS4 VHL â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 24002598 20844582 20300531
TRAF6 GSK3B â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 31594754 30711629 31754475 30806153
UBA6 UBE2Z â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 22427669 24528925 17597759 19250909 27569286 20975683 31575873
BRE1A UBE2A â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 24837678 19410543 21443952 25582440 28031328
NEDD4L UBE2D3 â—¼   PHYSICAL_INTERACTION 809.0 0.81 STRING 36370105
UBE2C CDC20 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 19820702 34382737 29735662 17443186 32152539
UBE2S VHL â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 30903204 32814053 27685940 32328410
ITCH RPS27A â—¼   PHYSICAL_INTERACTION 810.0 0.81 STRING 36370105
RPS27A WWP2 â—¼   PHYSICAL_INTERACTION 810.0 0.81 STRING 36370105
TP53 UBE2A â—¼   PHYSICAL_INTERACTION 811.0 0.81 STRING 36370105
ITCH TRAF6 â—¼   PHYSICAL_INTERACTION 813.0 0.81 STRING 36370105
EIF2S3 EIF3F â—¼   PHYSICAL_INTERACTION 813.0 0.81 STRING 36370105
BIRC7 UBB â—¼   PHYSICAL_INTERACTION 813.0 0.81 STRING 36370105
KLHL13 KLHL9 â—¼   PHYSICAL_INTERACTION 813.0 0.81 STRING 36370105
FBXW8 RBX1 â—¼   PHYSICAL_INTERACTION 815.0 0.81 STRING 36370105
CDC73 RNF20 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HuRI 32296183
BTRC UBB â—¼   PHYSICAL_INTERACTION 815.0 0.81 STRING 36370105
PCNA UBA52 â—¼   PHYSICAL_INTERACTION 816.0 0.81 STRING 36370105
CDC27 UBE2C â—¼   PHYSICAL_INTERACTION 816.0 0.81 STRING 36370105
CDK2 CDK1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 21319273
CTR9 CDK9 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 24981860 26496610
MDM2 CUL4B â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28225217 22032989
CUL4B UBB â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21145461 28225217
SKP2 CUL5 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21145461 21119685
CUL3 CUL5 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21145461 22709582
TRAF6 DDB1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17353931 25499913
CUL1 DDB1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21145461 22474075
HERC2 EIF3F â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 30279242 29426014
SHPRH HLTF â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 18719106 21396873
UBC MDM2 â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 19166840 6823655
JPH4 RAD18 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
RBX1 ELOC â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33504946 12149480
BIRC3 SUMO1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 30948266 21988832
SUMO1 ZMYM2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17027752 16524884
UBR4 UBE2A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 19549727 25582440
L2GL2 UBE2A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
JPH4 UBE2A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
UBE2A CD59 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 26496610 28031328
UBE2A UBR1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21900206 25582440
UBR4 UBE2B â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 19549727 25582440
BUB1 UBR5 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28689657 20360068
CUL4A WDR61 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31155351 17041588
CUL4A SKP1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21145461 22474075
SKP1 PSMF1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33961781 27705803
CDC73 ELOB â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31253590 26496610
SKP2 UBB â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
UBB UBE3A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 25416956 22645313
CDC16 BUB1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
SKP2 CUL1 â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 6540196 18239684
CTR9 CCNT1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 26659056 26496610
L2GL2 UBE2O â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
JPH4 UBE2O â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
UBE3A UBE3C â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22645313 29426014
ANAPC5 UBE2C â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
CDC26 UBE2C â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
ANAPC4 UBE2C â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
ANAPC16 UBE2C â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
ANAPC13 UBE2C â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
CDC23 UBE2C â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
ANAPC10 UBE2C â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
CDC20 CDK1 â—¼   PHYSICAL_INTERACTION 826.0 0.82 STRING 36370105
HUWE1 RPS27A â—¼   PHYSICAL_INTERACTION 826.0 0.82 STRING 36370105
UBB UBR5 â—¼   PHYSICAL_INTERACTION 826.0 0.82 STRING 36370105
RNF4 UBE2N â—¼   PHYSICAL_INTERACTION 828.0 0.82 STRING 36370105
EIF2S3 RPS27A â—¼   PHYSICAL_INTERACTION 828.0 0.82 STRING 36370105
BRCA1 RAD18 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 29656893 25184681 23901102
BRCA1 CDK9 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 22990118 28278048
CBL ITCH â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 12226085 19341794
CDK9 CUL1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 11689688 12861003
HERC2 BIRC6 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 25476789 26186194
L2GL2 RAD18 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 24366813 33961781
RBX1 ELOB â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 12048197 33504946 31253590 12149480
TRAF6 UBC â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 14743216 17703191 19820695 18239685
TRAF6 BIRC3 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 20097753 24464131 23524849 29545793
BIRC3 UBA1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 23524849 30948266 25260751
UBR3 UBE2A â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 19549727 21816346 25582440
UBE2A UBE2B â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 25582440
UBE2B UBR3 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 19549727 21816346 25582440
UBC XIAP â—¼   PHYSICAL_INTERACTION 829.0 0.83 STRING 36370105
BIRC7 XIAP â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194 22711539
BIRC2 XIAP â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 17069460 16263936 33961781 22711539
UBB UBE2D1 â—¼   PHYSICAL_INTERACTION 829.0 0.83 STRING 36370105
BRE1A CDC73 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 32296183 22021426 27462432
RPS27A UBE2S â—¼   PHYSICAL_INTERACTION 829.0 0.83 STRING 36370105
UBB UBE2L6 â—¼   PHYSICAL_INTERACTION 829.0 0.83 STRING 36370105
SKP2 CDC20 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 26811472 25306918 20663873 33961781 15014502
CDC27 BUB3 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 27114510 22193957 33961781 32152539 32076268 21926987
UBC UBE2L6 â—¼   PHYSICAL_INTERACTION 829.0 0.83 STRING 36370105
CTR9 ELOB â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 31253590 24981860 26496610
RBX1 UBE2G2 â—¼   PHYSICAL_INTERACTION 830.0 0.83 STRING 36370105
RPS27A SKP1 â—¼   PHYSICAL_INTERACTION 830.0 0.83 STRING 36370105
SKP1 UBB â—¼   PHYSICAL_INTERACTION 830.0 0.83 STRING 36370105
UBA1 UBE2E2 â—¼   PHYSICAL_INTERACTION 831.0 0.83 STRING 36370105
SKP1 UBE2D2 â—¼   PHYSICAL_INTERACTION 832.0 0.83 STRING 36370105
BTRC GSK3B â—¼   PHYSICAL_INTERACTION 832.0 0.83 STRING 36370105
PIAS2 TP53 â—¼   PHYSICAL_INTERACTION 834.0 0.83 STRING 36370105
UBA1 UBE2G2 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
CDC16 UBE2C â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
RAD18 RPS27A â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
BRCA1 UBE2E3 â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
BRCA1 UBE2E2 â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
BRCA1 UBE2E1 â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
BRCA1 UBE2N â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
CUL3 KLHL13 â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
BRCA1 CDK2 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
CBL UBE2D1 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
CDK1 BUB1 â—¼   PHOSPHORYLATION ✅ + 0.83 0.83 Signor 16760428
CUL1 UBB â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
CDK1 CDC20 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 28514442 10799291 26912231
CDK9 TP53 â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
CDK9 SKP2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 11689688 12861003
UBE4B MDM2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 24587254 21317885
NEDD4 UBA1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 18498243 18287095
SUMO1 PIAS4 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 20016603 15831457 16524884
TRIM32 UBE2D3 â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
TRIM32 UBE2E1 â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
CUL1 FBXW8 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
CUL1 CUL3 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
BIRC3 TRAF6 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
FZR1 UBE2S â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
HUWE1 UBA52 â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
RNF4 UBE2D3 â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
SUMO1 UBE2K â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
UBA52 UBR5 â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
UBB UBC â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
UBA52 UBE2S â—¼   PHYSICAL_INTERACTION 845.0 0.84 STRING 36370105
UBA52 UBE2L6 â—¼   PHYSICAL_INTERACTION 845.0 0.84 STRING 36370105
BIRC2 UBB â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
MDM2 UBA52 â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
RPS27A UBA6 â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
RPS27A UBQLN1 â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
ANAPC2 UBC â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
CDK1 SKP2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 28514442 26496610 33422522 33961781 26186194 32707033
DET1 CUL4B â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 28514442 33961781 16949367 31973889
SOCS3 CUL5 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 24438103 15601820 30166453 17135358
UBE2W FANCL â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 19549727 21229326 19111657
FBXW7 CUL1 â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 8399454 23108047
UBC MDM2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 17290220 19166840 18566590 19098711
RNF4 UBE2N â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 29642013 26148049 25260751
SUMO1 PIAS3 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 16524884 19217413 15569683 24654937
SOCS3 ELOB â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 15601820 33961781 17135358 16007195 30166453 10051596
CBLC ITCH â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 12226085
SOCS1 ELOB â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 21119685 31980649 10051596 29991678
TP53 UBE2D1 â—¼   PHYSICAL_INTERACTION 851.0 0.85 STRING 36370105
MDM2 UBB â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
CUL1 FBXO2 â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
PARK2 UBE2E2 â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
PARK2 UBE2G1 â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
UBE2L3 UBR5 â—¼   PHYSICAL_INTERACTION 855.0 0.85 STRING 36370105
SYVN1 UBE2D2 â—¼   PHYSICAL_INTERACTION 855.0 0.85 STRING 36370105
MDM2 UBE2K â—¼   PHYSICAL_INTERACTION 856.0 0.85 STRING 36370105
UBE2D3 UBE3A â—¼   PHYSICAL_INTERACTION 856.0 0.85 STRING 36370105
UBA1 UBE2D4 â—¼   PHYSICAL_INTERACTION 857.0 0.85 STRING 36370105
CDC20 FZR1 â—¼   PHYSICAL_INTERACTION 858.0 0.85 STRING 36370105
NEDD4 SMURF2 â—¼   PHYSICAL_INTERACTION 858.0 0.85 STRING 36370105
UBE4B UBQLN1 â—¼   PHYSICAL_INTERACTION 858.0 0.85 STRING 36370105
CDK2 TP53 â—¼   PHOSPHORYLATION ✅ + 0.86 0.86 Signor 24173284
CDK9 CDC73 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 26659056 17643375
MDM2 CUL1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 20708156 24804778
UBB RAD18 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 28506460 24981860
RAD18 PCNA â—¼   UBIQUITINATION ✅ + 0.86 0.86 Signor 19706603
TRAF6 UBE2L3 â—¼   PHYSICAL_INTERACTION 859.0 0.86 STRING 36370105
UBE2B BRE1A â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 28514442 27569044 19410543 21443952 25582440 33961781
CUL3 CUL1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 21145461 26344197
ELOC CUL3 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 21145461 21988832
BTRC UBC â—¼   PHYSICAL_INTERACTION 859.0 0.86 STRING 36370105
SIAH1 UBE2D3 â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
PCNA UBC â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
SIAH1 UBE2D1 â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
CUL3 UBE2M â—¼   PHYSICAL_INTERACTION 865.0 0.86 STRING 36370105
GSK3B TP53 â—¼   PHYSICAL_INTERACTION 866.0 0.86 STRING 36370105
CDC34 SKP2 â—¼   PHYSICAL_INTERACTION 866.0 0.86 STRING 36370105
RPS27A UBR5 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
CDK1 SKP2 â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
NEDD4 UBB â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
UBA1 UBE2W â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
NEDD4L UBB â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
CUL1 CDK2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 9636170 26186194 21145461 23455922
CDK2 CDC20 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 26811472 33961781 25852190 23455922
LEO1 WDR61 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 22451921 26496610 16024656 33961781 20305087 24981860 26344197
SUMO1 MDM2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 21316347 12917636 22411991 18583933 15876874 12393906 12297306 20972456 11384992 15876864 17000718
MDM2 UBE2A â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 22083959 12640129
PIAS1 SUMO1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 27032383 24654937 19217413 15561718 22578841 16524884 11583632 14609633 18806873
UBE2E2 MID1 â—¼   PHYSICAL_INTERACTION ✅ 0.87 0.87 mint 8153045 21516116
CUL4A CUL1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 17079684 21145461 32235678
SOCS3 ELOC â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 15601820 33961781 17135358 22084247 12783885 30166453 10051596
BUB1 CDC20 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 25669885 26811472 23443559 25306918 26496610 15525512 33961781 26186194 31118282 26912231
CDC26 CDC20 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 26811472 23443559 20360068 25306918 25723520
CUL3 KLHL9 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 19995937 31515271 17543862 33130828 21145461 19295130
CDC23 BUB3 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 33961781 20360068
BIRC7 BIRC2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 25416956 33961781 26186194 22711539 21113135
CDC23 CDC26 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 33961781 26496610 20360068
KCMF1 UBR4 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 25582440 22863883 29511261 33961781 26186194 26344197
FZR1 SKP2 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
MDM2 PML â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
NEDD4 UBA52 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
RNF7 UBE2D3 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
UBE2D1 XIAP â—¼   PHYSICAL_INTERACTION 0.87 0.87 HuRI 32296183
SKP1 UBC â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
RCHY1 UBE2D2 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
CUL1 FBXO4 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
HSP90AA1 HSPA1A â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
ANAPC4 BUB3 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
PSMD3 UBA52 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
TRIP12 UBE2D1 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
CDC20 SKP2 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
CBL UBE2L3 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
MAP3K1 MAPK1 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
PIAS1 TP53 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
ITCH UBE2D3 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
UBE2D3 WWP2 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
PCNA UBE2I â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
NEDD4L UBE2D1 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
UBA52 UBE2D1 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
UBA52 UBE2D2 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
CBLB RPS27A â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
EIF3F RPS27A â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
CUL1 UBE2D2 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
BTRC FBXW11 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
CTR9 WDR61 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
BRCA1 NBN â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
CDK2 SKP1 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
DDB2 RBX1 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
MID1 UBE2D3 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
BUB1 UBR5 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
KEAP1 RBX1 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
MAPK1 TP53 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
SUMO1 TP53 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
MID1 UBE2D1 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
RNF4 UBE2D2 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
CDC20 UBC â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
CTBP1 BRCA1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 21102443 16713569 10196224 31636387 11751867
BRCA1 UBE2N â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 19712108 21965653 17873885
BRCA1 UBA1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 12485996 11927591 14638690 12438698 26831064 11278247 12887909 15184379
BRCA1 UBE2K â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 19712108 23246971 21965653 17873885
BRCA1 UBE2W â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 25436519 19712108 21965653 17873885
ERCC8 CUL4B â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16949367 31973889 29531219 26496610 33961781 21145461 22902626
ERCC8 CUL4A â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16949367 31973889 29531219 12732143 29225035 21145461 16751180 26826127 22902626
FBXW8 RBX1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10531037 18498745 31343991 33961781 12481031 17205132 33504946
UBE3A HERC2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 21493713 30257870 30279242 22645313 25476789 29426014
TRAF6 XIAP â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16189514 25241761 22493164 12048196
BIRC2 XIAP â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
DET1 CUL4A â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 33961781 17452440 16964240 14739464 16949367
RTF1 CDC73 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16024656 20178742 15923622
OPTN UBB â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 31723608 22101367 23414517
SMURF1 SMURF2 â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
BUB3 BUB1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 16760428 16189514 25416956 21988832 26496610 26148513 9660858 11283619 33961781 26186194 20220147
CDC20 BUB3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 23643811 25482201 27114510 23443559 24464857 26811472 25306918 29973720 21407176 25833949 28410192 33961781 21926987
SIAH1 PIAS1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 17533377 27485016
CTR9 WDR61 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 22451921 20178742 26496610 16024656 33961781 20305087 24981860 26344197
CUL4A ERCC8 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
HUWE1 UBB â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
PML RNF4 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
CDC20 UBE2S â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
CUL7 SKP1 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
UBA1 UBE2A â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
UBE2D2 XIAP â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
BTRC CDC34 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
BUB3 CDC23 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
CUL7 RBX1 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
UBE2B UBR1 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
PML TP53 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
UBC UBE2G2 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
MAPK8 TP53 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
UBA1 UBE2R2 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
MAP3K1 MAPK8 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
CDC27 UBE2S â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
HLTF RAD18 â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
HUWE1 UBE2L3 â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
ANAPC15 CDC20 â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
ANAPC11 CDC20 â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
PARK2 UBE2D2 â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
UBE2D2 UBE3A â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
ANAPC15 FZR1 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
HERC2 UBE3A â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
HUWE1 UBE2D1 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
RNF4 UBE2D1 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
PCNA UBB â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
CUL4B DDB2 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
RCHY1 TP53 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
PARK2 UBE2N â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
NBN BRCA1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10426999 18171670 19244116 12124328 10783165 25659039 25184681 25939603 11504724 29656893
BRCA1 SUMO1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 26831064 18025037 20016594
CUL4A CUL4B â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17041588 31973889 23555860 18593899 33961781 16964240 21145461 30945288 32140073
TP53 CUL7 â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 8415349 22653443
FBXW8 CUL7 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17332328 10531037 16142236 21572988 23029530 17998335 18498745 31343991 17205132 12481031 23045529 21946088
CUL7 SKP1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10531037 17998335 27705803 31343991 33961781 12481031 23045529
DET1 DDB1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 33911083 33961781 31155351 17452440 16964240 14739464 16949367
ERCC8 DDB1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16949367 22232169 28416769 29531219 17392787 12732143 31970402 16751180 26826127 22902626
DDB1 RBX1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 22118460 20870715 16473935 15448697 16678110 30349055 33504946 16751180
DDB2 RBX1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16260596 28416769 16473935 25628365 26496610 12732143 33961781 30349055 20368362 16751180
FBXW7 RBX1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 32086376 28522751 21205095 33961781 33504946 31285543 11565034 22388891
FBXW8 CUL1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 21572988 21946088 25515538 17205132 29103612 21145461 22268729
CCNT1 PML â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28555140 12727882
RNF4 PML â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 29180619 19380586 24907272 15707587 23028697 18408734 21252943 18708055 24637324 22388745
RAD18 PCNA â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 21227930 23345618 26170230 31160570 21858012 22904075 32701997 28924044 31887036 17720710 20600238 18363965 20064529 30700555 31873223 17108083 15359278 18245774 33508099 20675655 24958773 27377895 30563767 28831681 21967848
RBX1 SKP2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 29499133 18826954 34237211 18667692 19112177 19398581 18239684 33961781 30349055 33504946 11245432 23770852
TP53 RCHY1 â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 17568776 5220017
TP53 RCHY1 â—¼   COLOCALIZATION ✅ 0.89 0.89 mint 17568776 5220017
UBE2B UBR1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 21422291 25582440 16169070
UBE2D3 UBE4B â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
VHL CUL2 â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 6542648 18323857
CDC73 WDR61 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 22451921 29774127 20178742 26496610 16024656 33961781 20305087 26186194 24981860 19136632 26344197
CDC20 CDC23 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 18997788 27114510 26811472 23443559 24464857 20360068 25306918 26496610 28404789
CDC26 CDC27 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 20360068 12956947 16364912 25723520 33961781 32152539 32076268 14657031 10922056 21043528
ANAPC15 ANAPC16 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
KCMF1 UBR4 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
CBL UBC â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
CUL7 FBXW8 â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
NEDD4 UBE2E1 â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
UBC UBE2D3 â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
UBE2D2 UBR5 â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
UBE2D1 UBE3C â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
RPS27A UBE2L6 â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
CDC34 UBB â—¼   PHYSICAL_INTERACTION 891.0 0.89 STRING 36370105
UBC UBE3C â—¼   PHYSICAL_INTERACTION 891.0 0.89 STRING 36370105
UBA6 UBE2D2 â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
ANAPC13 ANAPC15 â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
UBA1 UBE2D3 â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
PARK2 UBE2D3 â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
UBA1 UBE2S â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
UBA6 UBE2Z â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
UBC WWP2 â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
LEO1 WDR61 â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
CUL1 RPS27A â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
ITCH UBC â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
STUB1 TP53 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
RNF7 UBE2D1 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
CDKN2A TP53 â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
BIRC2 UBE2D1 â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
UBE2D2 UBE2K â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
BRCA1 UBE2D1 â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
CDK2 BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31270457 16713569 10373534 9244350 8764100
BRCA1 UBB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17873885 11320250 14636569
CBX5 LBR â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15882967 16189514 8663349
CDK1 PML â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17477081 23526763 21840486
SKP2 CDK2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 16189514 9858587 9636170 25852190 23455922 10559858 19270695 26496610 23602568 16979657 10386600 19686743 15355997 20160477 18604603 22770219 33422522 33961781 26186194 7553852
CDK2 SKP1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 7553852 26496610 25852190 33961781 9636170 23602568 16979657 23455922
PCNA CDK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10930425
CDK9 RCHY1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 23603988
RBX1 CSNK1E â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
RBX1 CUL4B â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 33969670 24292684 12481031 25189618 12609982 26496610 30349055 27113764 29499938 19250909 22038470 34026424 28446751 31973889 23238014 33961781 33504946 30945288 32140073
CUL4B DDB1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19651607 33969670 33357448 28225217 24292684 25189618 21145461 18593899 26496610 16678110 16964240 33536335 27113764 29499938 30898011 28886238 29738775 17392787 29846670 22939629 22038470 34026424 16949367 31911655 28446751 17041588 23238014 31973889 16861906 33961781 30945288 26344197 32140073
CUL4B DDB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 17041588 31973889 18593899 26496610 30923324 33961781 26186194 21145461 30945288 16949367
SOCS1 CUL5 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18481982 9869640 19649319
CUL5 ELOB â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 24438103 25499913 15574593 21145461 30166453 24076655 23806657 31253590 11384984 16530799 20463065 14564014 17351129 22479405 24402281 24390335 23098073 21119685 24390320
CUL5 ELOC â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 24438103 21199876 15574593 21145461 30166453 24076655 23806657 31253590 11384984 16530799 20463065 14564014 17351129 22479405 24402281 24390335 23098073 32513959 33961781 24390320
RBX1 CUL7 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 17332328 24793695 24793696
CUL7 RBX1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 10531037 16142236 25752541 31343991 33961781 12481031 33504946 16547496 23045529
CUL4A DDB1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 22952844 17079684 22118460 15448697 26613412 22910413 25349427 21145461 22474075 27462452 16473935 15811626 18606781 26231201 18593899 16678110 16964240 33536335 19295130 25982117 33759138 16260596 27113764 21113133 30898011 28886238 26976604 27203177 17392787 25795299 22939629 26344197 14739464 27294876 10585395 27573245 31911655 17041588 20870715 27203182 31973889 32235678 16861906 19966799 22342275 34251884 17626091 19287380 30945288 16949367 32140073
DDB1 DDB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 22118460 28035050 12050362 24249678 26410533 22822215 28416769 29262658 16473935 18593899 30923324 16678110 16964240 20368362 12812979 19295130 16751180 19109893 17360488 16260596 27203177 17392787 10777491 12151405 32985517 14751237 22039351 17041588 12732143 11564863 9418871 19966799 33961781 26186194 34251884 16949367
TP53 DDB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16357511 19382146
CUL4A DDB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 17079684 28514442 22118460 28035050 11564859 21145461 29262658 16473935 15811626 18593899 26496610 30923324 16964240 20368362 19295130 16751180 33759138 16260596 27203177 17609381 32985517 10585395 17041588 31973889 12732143 33961781 26186194 17626091 30945288 16949367
TP53 FBXW7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23518350 19366810 12824889
TP53 FBXW7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 31346036 12824889
FBXW8 SKP1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 10531037 26087183 21572988 18498745 21946088 27705803 31343991 17205132 12481031 20596027 33961781 15070733 22388891
ANAPC2 FZR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9811605 10500174
FZR1 ANAPC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9811605 10500174
UBE2B HLTF â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18719106 18316726 19723507
PCNA HLTF â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18719106 18316726 19723507
HLTF PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18719106 26350214
KEAP1 CUL3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 22911784 21357422 19818716 17822677 16449638 15367669 30765703 22558124 28186440 33130828 17439941 20599909 15282312 21145461 22448038 25742418 26757824 16790436 32296183 24896564 20534351 23727018 18251510 24127568 20027226 22245129 15983046 24322982 32341456 25628777 20421418 15572695 33391509 18417180 20865015 15601839 32854194 30273379 30383469 20864537 26219975
CDC73 LEO1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 29774127 18469135 20178742 21726809 26496610 15632063 16024656 15923622 20305087 26186194 33961781 24981860 22939629 19136632 26344197
LEO1 CTR9 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 18469135 20178742 22532828 26496610 15632063 16024656 24981860 20305087 27173435 22939629 26344197
LEO1 RTF1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 18469135 20178742 16024656 22939629 26344197
MDM2 PML â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 22869143 16713569 12915590 23169665 14507915 19150978 20972456 15195100 12759344
GSK3B MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16055726 18505846
SUMO1 PML â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11948183 16189514 9885291 19015637 21305000 23028697 28851805 23604351 15017387 22155184 21057547 19380586 24190887 20826694 20972456 23830076 17027752 24654937 25497731 9756909 21779164 31879127 17081986 18625722 8806687 17081985 17344210 19217413 17036045 18474224 9452416 20188669 16501610 22406621 22875967 9427741 15561718 21098080 11080164 11160742
TP53 PML â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14992722 18056437 14715247
SHPRH RAD18 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18719106 17130289 17108083
UBE2N RAD18 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18719106 18316726 19723507
SOCS3 RBX1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18481982 9869640 19649319
SOCS1 RBX1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18481982 9869640 19649319
RBX1 CUL2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19327355 17183367 12149480 15448697 10230407 12481031 29547696 32296183 11861641 15601820 30349055 22405651 25540389 10579999 19250909 21822215 21778237 29958295 22863883 33961781 33504946 28591624 17132228
RBX1 CUL4A â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 17079684 16189514 15448697 10230407 12481031 17452440 22474075 11861641 18593899 30349055 19295130 22405651 33759138 30352932 27113764 26976604 27203177 26990986 19250909 27203182 31973889 32235678 29958295 22863883 33961781 33504946 19287380 30945288 32140073
RBX1 VHL â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16503656 23401859 33567268 12048197 17353931 15601820 26735018 24469044 30349055 33504946 33137104 12604794 16261165 16325183
SUMO1 RNF4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 29180619 32296183 24907272 15707587 23086935 24151981 24844634
UBE2N SHPRH â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18719106 17130289 17108083
UBE2B SHPRH â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18719106 17130289 17108083
VHL SUMO1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 20844582 24002598 20300531
SUMO1 CTBP1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 20176810 20098713 12679040
PIAS2 SUMO1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 32296183 16189514 25416956 11867732 21988832 24654937 16524884 19217413 16204249 14609633 17036045
SUMO1 TRAF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18093978
TP53 UBA3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16980608
TP53 PIAS3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 24584189 11877452
TP53 SYVN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16980608
HSPA1A TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 7811761 16713569 8729618
TP53 HSPA1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 7811761 16713569 8729618
TRAF6 UBE2N â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 18710948 17327397 15147900 17709375 21113135 27791197 19810754 24610907 29950522 27695001 27918549 31074699 34490261 18617513 30979779 25548215 11057907 19465916 29537486 31638574 15327770 19549727 31578830 27173435 28244869 29432170 23885119
SOCS3 TRAF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18055217 16543409
UBA1 PIAS3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
UBA1 UBB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17597759 24816145 21209336
UBR1 UBE2A â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
UBE2N UBE2B â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18719106 18316726 19723507
UBE2D3 UBA52 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
UBE2L6 UBE2N â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16112642 16428300 16122702
UBE2N HERC5 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16112642 16428300 16122702
CUL2 ELOB â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19327355 24076655 31253590 12149480 15966899 12048197 15601820 25661653 11384984 24981860 18173839 21145461 9122164 30166453
CUL2 VHL â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16503656 22086907 28514442 9751722 10823831 15060148 11865071 21942715 27697924 20049704 26743088 11779168 17439941 12604794 9122164 21145461 15611064 19030229 21685897 12048197 10421634 28775317 15601820 10449727 24469044 11384984 10587522 18173839 22286099 17339318 16261165 16611863 23401859 15966899 22234250 9447969 17353931 26751167 18323857 25661653 33137104 11024059 18187417 18523483 10318914 26735018 24981860 33961781 31444342 26846855 17132228
GSK3B UBE2D1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
SOCS3 SOCS1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 17363902 14512302 9885206
CDC73 CTR9 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 29774127 18469135 20178742 22532828 21726809 26496610 15632063 16024656 22863883 15923622 20305087 26186194 33961781 24981860 22939629 19136632 26344197
UBE2R2 UBA52 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
UBA52 PRKN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24784582 26161729 24856362
TGFBR2 SMURF2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15496141 11163210 11278251
TGFBR2 SMURF1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15496141 11163210 11278251
TGFBR2 NEDD4L â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15496141 11163210 11278251
PLG PLAU â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 2521625 2935528 1829461
PLAU PLG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 3920216 2829380 4226004
CDC20 CDC16 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 18997788 27114510 24100295 26811472 23443559 24464857 20360068 25306918 12956947 26496610 12196507 9628895 23007648
CDC20 CDC27 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 24100295 20081372 24464857 20360068 16479161 24781523 25246557 17443180 18471975 18997788 18059335 23239745 23643811 25161877 20054826 14561775 22193957 25750436 20212161 21926987 22280307 21937719 19098431 25673878 26811472 27114510 29700288 25306918 12956947 9811605 23754430 18794143 9628895 17443186 32076268 21525009 22100920 23160376 24811168 20951947 9637688 23443559 9736712 22014574 9734353 18722180 30341343 25156254 17609108 28404789 29432156 26960431 21335556 12196507 32152539 23979597 21454660 17360335 23007861
CUL1 SKP2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 16189514 17704768 12840033 18667692 15456869 18239684 12504026 9636170 12609982 17439941 21145461 10559858 9736735 17438373 23951410 19398581 28614300 22464731 22013077 29137415 30349055 19270694 16774918 18173839 23770852 24085301 21249194 29499133 23868976 22310285 11961546 9430629 32313199 10559916 25143387 20160477 10230406 9663463 22524983 34237211 21119685 33422522 27542266 29103612 16880511
GSK3B CDK5 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 17607942 15676027 15652488
VHL UBE2I â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 20844582 24002598 20300531
ELOB VHL â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16503656 28514442 10205047 9751722 7660130 10823831 15060148 21942715 20049704 12604794 9122164 14636579 19030229 31253590 10635329 32328410 12048197 28775317 15601820 10449727 17922844 20871634 24469044 10587522 18173839 22286099 17339318 25500545 22234250 12050673 17353931 17986458 26751167 18323857 25661653 30890701 7660122 15935760 12697815 18187417 12004076 26735018 27517496 24981860 33961781
ELOC VHL â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16503656 28514442 9751722 10205047 7660130 10823831 15060148 21942715 12604794 9122164 14636579 15611064 19030229 21685897 17558023 10635329 32328410 10421634 28775317 15601820 10449727 17922844 20871634 24469044 10587522 25500545 8674032 22234250 20300531 17353931 17986458 11739384 17244529 26751167 29401731 18323857 25661653 30890701 33137104 7660122 15935760 12697815 18187417 30267325 12004076 26735018 27517496 24981860 33961781 18305400 29121446
UBE2I CTBP1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 20176810 20098713 12679040
UBR1 GSK3B â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CDC16 CDC27 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 24100295 20360068 17187060 21186364 26496610 22193957 9356466 20733055 21043528 27114510 7736578 16648845 25306918 12956947 9628895 32076268 22939629 10922056 16364912 33961781 27173435 32152539 9405394 14657031 26344197
CDC27 CDC23 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 20360068 22792066 26496610 22193957 17942546 22280307 21043528 27114510 16648845 32934012 12956947 32076268 20686030 22939629 10922056 16364912 27173435 32152539 14657031 26344197
CDC23 CDC27 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17145710 10500174
ANAPC4 CDC27 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 25383541 10500174
ANAPC5 CDC27 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16189514 10500174
CDC27 ANAPC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 25383541 10500174
CDC27 ANAPC5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16189514 10500174
CDC27 CDC23 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17145710 10500174
CDC16 CDC26 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 32296183 25416956 21988832 20360068 26496610 25723520 19668213 33961781 21516116 26344197
CDC23 CDC16 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10318877 10500174
ANAPC10 CDC16 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10318877 10500174
CDC16 CDC23 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10318877 10500174
CDC16 ANAPC10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10318877 10500174
ANAPC10 CDC23 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10318877 10500174
CDC23 ANAPC10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10318877 10500174
UBE2L6 UBE2E1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16112642 16428300 16122702
ANAPC11 UBE2C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 31942069 11739784 25959309
BRCA1 TP53 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
CUL7 TP53 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
FBXO4 SKP1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
HSP90AA1 TP53 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
NEDD4 UBE2D1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
PML UBE2I â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
RNF4 SUMO1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
UBA1 UBE2C â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
SMURF2 UBE2D3 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
RNF20 RNF40 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
RNF7 UBE2F â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
PSMD3 UBC â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
PSMD3 UBB â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
RBX1 UBE2L3 â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
STUB1 UBE2W â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
PARK2 UBA52 â—¼   PHYSICAL_INTERACTION 902.0 0.9 STRING 36370105
CUL4A DET1 â—¼   PHYSICAL_INTERACTION 903.0 0.9 STRING 36370105
ITCH UBE2D2 â—¼   PHYSICAL_INTERACTION 903.0 0.9 STRING 36370105
UBE2D1 UBE3A â—¼   PHYSICAL_INTERACTION 904.0 0.9 STRING 36370105
RPS27A SMURF2 â—¼   PHYSICAL_INTERACTION 904.0 0.9 STRING 36370105
BTRC UBE2D2 â—¼   PHYSICAL_INTERACTION 905.0 0.9 STRING 36370105
PSMD3 RPS27A â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
UBB UBE2D2 â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
NEDD4L UBE2L3 â—¼   PHYSICAL_INTERACTION 907.0 0.9 STRING 36370105
UBE2N UBA1 â—¼   PROTEIN_INTERACTION 0.91 0.91 HIPPIE 31638574 14517261 18678647 25527291 27173435 30097011 33619271 27182664 29537486
UBA1 UBE2E1 â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
RNF40 UBE2B â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
CUL1 RNF7 â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
CDK2 SKP2 â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
RPS27A UBE2D1 â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
TRAF6 UBC â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
CDKN2A MDM2 â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
PIAS1 SUMO1 â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
CDC34 UBA1 â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
PARK2 RPS27A â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
HSPA1A STUB1 â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
SMURF1 UBE2D3 â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
SMURF1 UBE2L3 â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
SMURF2 UBE2L3 â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
ANAPC11 UBE2K â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
BRCA1 UBE2D3 â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
HSP90AA1 STUB1 â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
UBA1 UBE2G1 â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
BUB3 CDC20 â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
SMURF2 UBC â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
UBA1 UBE2L3 â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
CDC20 CDK2 â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
CDK2 FZR1 â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
ANAPC13 FZR1 â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
MDM2 UBE2D3 â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
TP53 UBE3A â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
UBA1 UBE2N â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
FBXW11 CUL1 â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 25609649
NEDD4 UBE2D2 â—¼   PHYSICAL_INTERACTION 921.0 0.92 STRING 36370105
TP53 UBE2I â—¼   PHYSICAL_INTERACTION 921.0 0.92 STRING 36370105
UBA1 UBB â—¼   PHYSICAL_INTERACTION 922.0 0.92 STRING 36370105
PIAS4 UBE2I â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
RPS27A TRAF6 â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
ANAPC2 UBE2D2 â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
NEDD4 UBE2D3 â—¼   PHYSICAL_INTERACTION 924.0 0.92 STRING 36370105
UBE2L3 UBE3A â—¼   PHYSICAL_INTERACTION 924.0 0.92 STRING 36370105
CUL4A DDB2 â—¼   PHYSICAL_INTERACTION 925.0 0.92 STRING 36370105
FBXW8 SKP1 â—¼   PHYSICAL_INTERACTION 925.0 0.92 STRING 36370105
CUL1 UBC â—¼   PHYSICAL_INTERACTION 925.0 0.92 STRING 36370105
NEDD4 UBE2L3 â—¼   PHYSICAL_INTERACTION 928.0 0.92 STRING 36370105
RBX1 UBE2M â—¼   PHYSICAL_INTERACTION 0.92 0.92 HuRI 32296183
CTR9 CDC73 â—¼   PHYSICAL_INTERACTION ✅ 0.93 0.93 mint 24981860
CUL1 BTRC â—¼   PHYSICAL_INTERACTION ✅ 0.93 0.93 mint 17318178 5219675
SKP1 FBXW11 â—¼   PHYSICAL_INTERACTION ✅ 0.93 0.93 mint 5212166 10644755
VHL ELOB â—¼   PHYSICAL_INTERACTION ✅ 0.93 0.93 mint 6542648 18323857
RNF20 UBE2A â—¼   PHYSICAL_INTERACTION 931.0 0.93 STRING 36370105
UBE2L3 WWP2 â—¼   PHYSICAL_INTERACTION 931.0 0.93 STRING 36370105
RAD18 UBB â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
BIRC7 UBC â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
ANAPC15 CDC27 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
ANAPC1 ANAPC15 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
ANAPC15 CDC16 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
ANAPC15 CDC26 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
ANAPC15 CDC23 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
UBE2L3 WWP1 â—¼   PHYSICAL_INTERACTION 933.0 0.93 STRING 36370105
ANAPC15 ANAPC5 â—¼   PHYSICAL_INTERACTION 933.0 0.93 STRING 36370105
ANAPC15 ANAPC7 â—¼   PHYSICAL_INTERACTION 933.0 0.93 STRING 36370105
ANAPC11 UBE2S â—¼   PHYSICAL_INTERACTION 933.0 0.93 STRING 36370105
DDB1 DET1 â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
HSP90AA1 HSPA1B â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
FZR1 UBE2C â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
UBC UBR5 â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
CDC20 UBE2C â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
ANAPC1 ANAPC11 â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
UBB UBE2S â—¼   PHYSICAL_INTERACTION 938.0 0.93 STRING 36370105
BUB1 BUB3 â—¼   RELOCALIZATION ✅ + 0.93 0.93 Signor 11402067
UBA1 UBE2B â—¼   PHYSICAL_INTERACTION 939.0 0.94 STRING 36370105
PCNA RPS27A â—¼   PHYSICAL_INTERACTION 939.0 0.94 STRING 36370105
FBXW7 UBA52 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
RNF20 UBE2B â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
UBA1 UBE2D1 â—¼   PHYSICAL_INTERACTION 945.0 0.94 STRING 36370105
HLTF UBE2N â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
ANAPC11 UBE2D1 â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
UBA52 UBE2K â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
UBA1 UBE2D2 â—¼   PHYSICAL_INTERACTION 948.0 0.94 STRING 36370105
CBLB UBE2D2 â—¼   PHYSICAL_INTERACTION 948.0 0.94 STRING 36370105
HLTF PCNA â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 18719106 26350214 22904075 30696947 32701997 28924044 18316726 31973093
CUL3 RBX1 â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 19818716 15448697 12481031 11861641 30349055 25270598 20027226 22405651 26100637 19256485 11311237 19250909 25278611 26286618 20865015 15601839 19617556 29958295 33504946 12684064 24145166
UBE2I SUMO1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 5219915 17491593
PCNA SUMO1 â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 21167178 22457066 22153967
SKP1 CUL1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 7304783 18818696
SKP2 SKP1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 6540196 18239684
ELOC ELOB â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 8153045 21516116
ANAPC13 CDC20 â—¼   PHYSICAL_INTERACTION 951.0 0.95 STRING 36370105
UBA1 UBA52 â—¼   PHYSICAL_INTERACTION 952.0 0.95 STRING 36370105
ANAPC11 CDC23 â—¼   PHYSICAL_INTERACTION 952.0 0.95 STRING 36370105
RNF40 UBE2A â—¼   PHYSICAL_INTERACTION 954.0 0.95 STRING 36370105
UBB UBE2N â—¼   PHYSICAL_INTERACTION 954.0 0.95 STRING 36370105
RPS27A UBE2D2 â—¼   PHYSICAL_INTERACTION 954.0 0.95 STRING 36370105
UBC UBQLN1 â—¼   PHYSICAL_INTERACTION 954.0 0.95 STRING 36370105
ANAPC10 ANAPC5 â—¼   PHYSICAL_INTERACTION 954.0 0.95 STRING 36370105
RBX1 UBE2R2 â—¼   PHYSICAL_INTERACTION 955.0 0.95 STRING 36370105
UBA1 UBE2K â—¼   PHYSICAL_INTERACTION 955.0 0.95 STRING 36370105
UBB UBE2K â—¼   PHYSICAL_INTERACTION 955.0 0.95 STRING 36370105
ANAPC5 CDC26 â—¼   PHYSICAL_INTERACTION 955.0 0.95 STRING 36370105
UBA52 UBE2N â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
UBA52 UBB â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
UBA52 UBC â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
RPS27A UBB â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
RPS27A UBC â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
PARK2 UBB â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
BTRC RBX1 â—¼   PHYSICAL_INTERACTION 958.0 0.95 STRING 36370105
CDC34 CUL1 â—¼   PHYSICAL_INTERACTION 958.0 0.95 STRING 36370105
PCNA CDK2 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 12361598 28514442 26496610 29510343 9545286 33961781 26186194 7903056 21319273 10930425
HLTF UBE2N â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 18719106 18316726 30696947 22904075
HLTF RAD18 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 18719106 23555860 21396873 25023518 18316726
SUMO1 SAE1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 9920803 20164921 15660128 19246003 12941704 12924945
UBC TP53 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 17568776 5220017
SKP1 BTRC â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 9660940 6547997
SKP1 FBXL6 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 32576198 19159283 27705803 33961781 26344197
SOCS1 ELOC â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 17183367 31980649 29991678 22787435 21119685 16643902 10051596
CTR9 RTF1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 18469135 20178742 16024656 22939629 26344197
RPS27A UBE2N â—¼   PHYSICAL_INTERACTION 962.0 0.96 STRING 36370105
RPS27A UBE2K â—¼   PHYSICAL_INTERACTION 962.0 0.96 STRING 36370105
PIAS2 UBE2I â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
FBXW7 RBX1 â—¼   PHYSICAL_INTERACTION 964.0 0.96 STRING 36370105
BUB1 CDC20 â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
FBXO2 SKP1 â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
PIAS1 UBE2I â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
STUB1 UBE2D3 â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
ITCH UBE2L3 â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
ANAPC2 UBE2C â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
BIRC2 UBC â—¼   PHYSICAL_INTERACTION 967.0 0.96 STRING 36370105
ANAPC10 ANAPC13 â—¼   PHYSICAL_INTERACTION 967.0 0.96 STRING 36370105
STUB1 UBE2D2 â—¼   PHYSICAL_INTERACTION 968.0 0.96 STRING 36370105
RPS27A UBA1 â—¼   PHYSICAL_INTERACTION 968.0 0.96 STRING 36370105
UBC UBE2D1 â—¼   PHYSICAL_INTERACTION 968.0 0.96 STRING 36370105
BIRC7 UBE2D2 â—¼   PHYSICAL_INTERACTION 968.0 0.96 STRING 36370105
CDK9 CCNT1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 9499409 11145967 15328539 17643375 20562857 9491887 20305087 15713662 19387490 11713532 27684187 14627702 23455922 16980611 26659056 15107825 12588988 12944466 14580347 20153263 22959624 16109377 12115727 21729782 23602568 11282025 30649429 19914168 18483487 24367103 20535204 12832472 19818711 12894230 9872325 23064645 30652970 15713661 21697490 22483617 22939629 32707033 11713533 15528190 15546612 10958691 10617616 10574912 18566585 10465067 24981860 33961781 11689688 17700062 26186194 26344197
CUL5 RBX1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 31253590 18805092 10230407 11861641 14564014 25912140 19250909 30349055 15574593 22405651
FBXW7 CUL1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 28522751 23108047 23322298 28007894 21145461 22388891 29695787 23453757 14603323 22405651 29499133 31285543 25143387 32086376 22524983 11585921 25515538 25720964 26976582 21205095 29103612 33961781 29408378 11565034 32350066
MDM2 UBC â—¼   PHYSICAL_INTERACTION 969.0 0.97 STRING 36370105
RAD18 UBE2A â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 26170230 21858012 22904075 25023518 31887036 18363965 24672041 15509568 25582440 26496610 18926833 17108083 15359278 10884424 27377895 10908344 22456510 19549727 21967848 24981860
RAD18 UBE2B â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 21422291 21858012 17720710 18363965 20064529 31873223 21549715 25582440 15359278 18245774 33508099 27569044 20675655 10884424 24958773 27377895 10908344 30367120 19549727 33961781
RBX1 SKP1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 16189514 12504025 12840033 12481031 26540345 11245432 29507117 10531037 16357137 30349055 15452136 12813041 23770852 29499133 12628165 11961546 29863914 33692209 27705803 33504946 12684064
CUL2 ELOC â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 19327355 17183367 24076655 19339690 15966899 23563313 9447969 15601820 10449727 26735018 25661653 11384984 31444342 24981860 21145461 9122164 30166453 29991678
FBXW11 SKP1 â—¼   PHYSICAL_INTERACTION 969.0 0.97 STRING 36370105
SKP2 SKP1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 16189514 18667692 15456869 30254149 18239684 20041211 16275325 12609982 10559858 23911321 26087183 18818696 23261596 31467278 9827542 10918611 19398581 28614300 22464731 29137415 16376880 15452136 19270694 26474281 12813041 34080260 23770852 24085301 29499133 30728155 17463251 23868976 22310285 11961546 9430629 11099048 22632967 10559916 20160477 15469821 22524983 10531035 34237211 29997244 27705803 33422522 33961781 32350066 16880511 27220724 15070733 15342634
UBE2I UBE2K â—¼   PHYSICAL_INTERACTION 969.0 0.97 STRING 36370105
ELOC ELOB â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 16189514 10205047 25416956 12149480 20211142 23333304 21516116 30166453 23988114 32296183 31253590 19159283 10449727 17922844 10587522 12050673 9447969 17997974 11739384 29401731 24402281 7660129 22939629 21822215 10224134 12004076 22863883 24981860 31444342 16675548 26344197
CDC73 WDR61 â—¼   PHYSICAL_INTERACTION 970.0 0.97 STRING 36370105
HLTF PCNA â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
SAE1 UBE2I â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
ANAPC1 CDC26 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
ANAPC1 ANAPC16 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
ANAPC7 CDC26 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
ANAPC16 ANAPC7 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
ANAPC15 ANAPC4 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
HUWE1 UBC â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
ANAPC1 ANAPC13 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
ANAPC10 ANAPC15 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
MDM2 RPS27A â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
ANAPC16 CDC20 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
CDC20 CDC26 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
CBLB UBC â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
ANAPC16 ANAPC5 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
ANAPC16 CDC16 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
ANAPC16 CDC26 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
ANAPC13 CDC26 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
ANAPC13 ANAPC7 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
ANAPC10 ANAPC16 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
CUL1 FBXW11 â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
BIRC2 UBE2D2 â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
CDC23 CDC26 â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
ANAPC13 ANAPC16 â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
UBC UBE2S â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
UBC UBE2D2 â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
ANAPC13 ANAPC5 â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
ANAPC16 CDC23 â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
ANAPC5 ANAPC7 â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
CBL UBE2D2 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
PML SUMO1 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
OPTN UBC â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
ANAPC5 CDC20 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
NEDD4L UBE2D2 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
ANAPC13 CDC27 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
ANAPC13 ANAPC2 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
ANAPC15 ANAPC2 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
CDK9 CCNT1 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 6613869 18483487
SUMO1 UBA2 â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
CDC16 CDC23 â—¼   PROTEIN_INTERACTION 0.98 0.98 HIPPIE 28514442 20360068 26496610 33961781 27173435 10318877 22939629 26344197
ANAPC10 ANAPC7 â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
DDB1 RBX1 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
CDK5 PCNA â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
ANAPC16 CDC27 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
ANAPC5 CDC23 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
ANAPC16 ANAPC2 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
ANAPC1 ANAPC7 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
ANAPC13 CDC16 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
ANAPC4 CDC26 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
ANAPC10 CDC26 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
ANAPC13 CDC23 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
ANAPC16 ANAPC4 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
BIRC3 UBE2D2 â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
CUL5 RNF7 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
MDM2 UBE2D2 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
STUB1 UBE2N â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
ANAPC7 CDC23 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
ANAPC13 ANAPC4 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
CUL4B RBX1 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
CUL5 RBX1 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
NEDD4 UBC â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
NEDD4 RPS27A â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
PIAS2 SUMO1 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
NEDD4L UBC â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
ANAPC7 CDC16 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
DDB1 ERCC8 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
PCNA RAD18 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
SAE1 SUMO1 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
CDC34 UBC â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
CUL1 UBE2M â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
UBA3 UBE2M â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
RPS27A TP53 â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
ANAPC4 CDC20 â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
CDC16 CDC26 â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
RBX1 UBE2D2 â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
CDC73 RTF1 â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
ANAPC10 CDC20 â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
ANAPC5 CDC16 â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
ANAPC10 FZR1 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
RAD18 UBE2A â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
CUL4A RBX1 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
ANAPC2 CDC20 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
ANAPC10 ANAPC11 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
FBXW7 SKP1 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 28522751 26540345 28007894 22388891 26087183 28614300 32350066 26474281 19412162 21620836 29346117 31210753 12628165 23791182 30728155 27247421 31285543 33658012 20596027 22632967 32086376 24811168 22524983 8051045 11585921 25720964 26976582 21205095 29408378 11565034 17434132 15070733
TP53 MDM2 â—¼   PHYSICAL_INTERACTION ✅ 0.99 0.99 mint 17139261 5219401
RBX1 CUL1 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 16189514 12504025 20832730 15448697 10230407 19933270 12840033 12904573 18723677 12504026 12481031 17452440 12609982 26540345 27697867 22474075 11245432 22767593 28152074 22822056 19245792 12706828 11861641 20399188 10748083 11956208 11483504 27910872 16759355 30349055 10713156 11027288 21765416 20638939 22405651 23770852 19942853 10648623 12565873 18826954 18805092 32145688 21169563 27591266 22660580 11961546 32313199 15361859 19250909 29863914 24949976 10230406 32726803 30653357 32015321 33692209 16123592 34237211 29958295 29103612 33961781 33504946 12684064 26725323 26344197
UBA1 UBC â—¼   PHYSICAL_INTERACTION 989.0 0.99 STRING 36370105
CUL3 RBX1 â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
CUL1 FBXW7 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
ANAPC1 CDC20 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
ANAPC11 CDC16 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
CDK2 PCNA â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
MDM2 UBE2D1 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
CUL2 RBX1 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
SUMO1 UBE2I â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
TRAF6 UBE2N â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
ANAPC11 FZR1 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
RPS27A UBA52 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
BUB1 CDC20 â—¼   PHOSPHORYLATION ✅ - 0.99 0.99 Signor 15525512
CDC20 CDC23 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
PARK2 UBE2L3 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
FBXW7 SKP1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
LEO1 RTF1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
RBX1 UBE2D3 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
RBX1 UBE2D1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
PARK2 UBC â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
UBC UBE2K â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CTR9 RTF1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CUL4B DDB1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
BTRC CUL1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
CDC73 LEO1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
RAD18 UBE2B â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
CDC73 CTR9 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
UBA2 UBE2I â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
SAE1 UBA2 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
ANAPC1 ANAPC10 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
ANAPC1 CDC23 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
ANAPC1 CDC16 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
ANAPC10 CDC16 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
CDC16 CDC23 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
ANAPC11 UBE2C â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
CDC16 CDC20 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
ANAPC10 CDC23 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
ANAPC11 UBE2D2 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
ANAPC4 FZR1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CDC26 FZR1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ANAPC7 FZR1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ANAPC2 FZR1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ANAPC5 FZR1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CTR9 LEO1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
MDM2 TP53 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
RAD18 UBC â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CDC34 RBX1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
STUB1 UBE2D1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
UBC UBE2N â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ANAPC7 CDC20 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ANAPC2 CDC27 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CDC23 CDC27 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ANAPC5 CDC27 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CDC26 CDC27 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ANAPC4 CDC27 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CDC16 CDC27 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ANAPC7 CDC27 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ANAPC11 CDC27 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ANAPC10 CDC27 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ANAPC1 CDC27 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ANAPC1 ANAPC5 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ANAPC4 ANAPC5 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ANAPC2 ANAPC5 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ANAPC11 ANAPC2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ANAPC1 ANAPC2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ANAPC2 CDC16 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ANAPC2 CDC26 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ANAPC2 ANAPC4 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ANAPC2 ANAPC7 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ANAPC1 ANAPC4 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ANAPC4 CDC16 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ANAPC4 ANAPC7 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ANAPC11 ANAPC4 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
NBN BRCA1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
PCNA BRCA1 â—¼   PHYSICAL_INTERACTION 49.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 9488723
PCNA BRCA1 â—¼   SHARES_COMPLEX 49.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BRCA1 BUB1 â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 10367887 10779360 10962562 11877377 12024039 12170778 12496474 12771027 15242590 15459660 15485915 16818604 19004803 19357644 19686080 19788416 19793801 20029420 21060331 21337561 9346961 9892649
BRCA1 DDB2 â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 10367887 10779360 10962562 11877377 12024039 12170778 12496474 12771027 15242590 15459660 15485915 16818604 19004803 19357644 19686080 19788416 19793801 20029420 21060331 21337561 9346961 9892649
CTBP1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20818429 21681822 23303449
TP53 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 24.0 1.0 Omnipath 9582019 11295099 18625847 11003642 12802282 16357511 14710355 9619832 19882681 10884389 11384963 11782367 12024039 15735697 12170778 21245169 17993233 12549011 11431698 16229810 18208621 10597265 21742769
CDK2 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 8764100 10373534 10550055 19683496 16713569 26719576 15212693
UBE2D3 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 11927591 21531767 16713569 21756275 12732733 22863316 17349954 21113135 25355358 21532592 18369654 16818604 20351172 15905410 16628214 19712108 21965653 15886201 15367667 23246971 12438698 17283126
CDK1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 9244350 21706030 10550055 17570479 19683496 16713569 26745677 32193285 26719576
HSP90AA1 CBL â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 17177598 16187797 15284455 16849543 16969069 16953218 17699773 17372273 17712310
CDK1 CDC20 â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 12124778 14551205 14614141 15242590 15279786 15375219 15377654 15485915 15917306 16713580 16818604 17303408 17596790 17660363 18414028 18543256 18590585 18995830 19652693 19686080 7575488 9892021
TP53 CDK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 10825186 11593387 12874009 19472317 10514438 11313928 16807237 8270002 17942917 9275177 20395210 11032828 19861536 12889596 19067706
GSK3B CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 9832503 17359287
CDK1 ANAPC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 19652693 18590585 7575488 17303408 12124778 17660363 15279786 15917306
CDK1 UBE2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 11953320
CDK1 ANAPC11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 19652693 18590585 7575488 17303408 12124778 17660363 15279786 15917306
CDK1 CDC26 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 19652693 18590585 7575488 17303408 12124778 17660363 15279786 15917306
CDK1 CDC23 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 19652693 18590585 7575488 17303408 12124778 17570479 17660363 14657031 15279786 15917306
CDK1 ANAPC5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 19652693 18590585 7575488 17303408 12124778 17660363 15279786 15917306
CDK1 CDC27 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 19652693 18590585 7575488 16565220 17303408 29084198 33819340 12124778 17570479 17660363 14657031 15279786 15917306
CDK1 BUB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 26912231 28072388 23637705 29971233 29868582 16760428 20633640 33125045
CDK1 ANAPC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 19652693 18590585 7575488 16565220 17303408 12124778 17570479 17660363 14657031 15279786 15917306 15302935
CDK1 UBA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 19651622 20068231 7724583 19413330 7673335 18669648 9099746
CDK1 ANAPC7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 19652693 18590585 7575488 17303408 12124778 17660363 15279786 15917306
CDK1 ANAPC10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 19652693 18590585 7575488 17303408 12124778 17660363 15279786 15917306
CDK1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 24173284 12767922 1584757 20661218 26029996 2141171 9467949 17570479 20808790 7862459 11327730 11078726 27726420 8357826 16713569 2156209
CDK1 LBR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 14718546 9045635 17570479 20576617 21795390
CDK1 ANAPC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 19652693 18590585 7575488 17303408 12124778 17660363 14657031 15279786 15917306
CDK1 CDC16 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 19652693 18590585 7575488 16565220 17303408 18420821 12124778 17660363 16964243 14657031 15279786 15917306
CDK1 EEF1D â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 17081983 20166139 18767875 19413330 19664995 19415658 8051108 20068231 18452278 16189514 12551973 18669648 33521052 18691976 17287340 20068230 19651622 19691289 17924679 18212344
CDK2 FZR1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 10323868 10375532 16582612 12730199
CDK2 CDKN2A â—¼   DOWN_REGULATES ✅ - 32.0 1.0 ACSN 11274345 11283614 12545156 14536078 15147722 15155580 15279786 17055429 17303408 17550342 17558397 17660363 17873522 18590585 18636226 20027199 20237412 20551172 20581311 20713526 20818389 21406394 21733352 2191300 21919891 22067385 23140366 23869868 25002027 28536364 7575488 9618481
MAPK1 CDK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10962581 12359725
SKP1 CDK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 7553852 23602568 16979657 9636170 26496610 25852190
CDK2 SKP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 7553852 20160477 23602568 25271736 18239684 28446188 23226679 10386600 19270695 26496610 16189514 25852190 26186194 25788262 9858587 22770219 15355997 10559858 23807222 22311674 16979657 9636170 19686743 19270694 18604603 23455922
CDK2 FZR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 11598127 15577895 9736735 12560341 15558010 20068231 10548110 16123593 15840442 18669648
CDK2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 39.0 1.0 Omnipath 24173284 9315650 19413330 19664995 16083285 1088347 16552184 10884347 17570479 10747897 25241761 7624134 11687964 17287340 92065884 12064478 19556892 14640983 10348343 14702041
CDK2 NR1I2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 22829544 23264496 28911860 32205367 18784074 26119819 32798464 24184507 26877237
CDK2 UBE2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 11953320 17570479
CCNT1 CDK9 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
CDK9 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 24173284 9372954 11483158 9315650 19413330 19664995 23603988 24202322 11709713 16083285 1088347 16552184 10884347 24286312 10747897 17942552 16741955 17287340 92065884 12064478 10348343 14702041
TP53 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 16103197 22467867 18555006 8631601 11402335 19649205 22020338 21164364 17265068 16764954 15775976 22056554 18275833 21483786 10348346 19216023 12384561 12091906 19901969 11360201 15205322 11818069 21892281 10980602 11739748 11559812 24672805 10097151 17907153 19244234 15361884 10652576 9436028 21447739 20569441 21555589 21637567 10816133 9774662 19240179
TRIP12 CDKN2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20208519
CDKN2A MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 57.0 1.0 Omnipath 12167711 18541670 23416275 9529249 17426254 12630860 17116689 12085228 15856024 10822382 19166854 12209154 12740913 17158541 16915296 17909018 25809483 9653180 14612427 22120712 16173922 10871849 18418067 24769896 9724636 21133853 10801444 19049976 9529248 16107876 18813780 20713054 18467333 15355988 18583933 20395212 11223036
CDKN2A TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 15856024 15989956 9724636 19960022 12740913 17158541 12640129 19590512
CDKN2A HUWE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17145710 16915296 15989956
CSNK1E TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10606744 11709713 10951572 10734067 16713569 11551930 10747897 10673501 11883897
PCNA CUL4B â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RBX1 CUL4B â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 22466611 24127601 23973375 22466612 20541997 22466610 23906714 16751180 22902626
ERCC8 CUL4B â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 22466611 24127601 23973375 22466612 20541997 22466610 23906714 16751180 22902626
UBE2M CUL4B â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 19617556 18826954 25349211 26460955 25314029 18206966 23201271 26906416 19250909 25531226 26344709
UBE2M DDB1 â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 19617556 18826954 25349211 26460955 25314029 18206966 23201271 26906416 19250909 25531226 26344709
RBX1 DDB1 â—¼   PHYSICAL_INTERACTION 27.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19270156 19440234 19557001 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
CUL4A DDB1 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
PCNA DDB1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
ERCC8 DDB1 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 22466611 24127601 23973375 22466612 20541997 22466610 23906714 16751180 22902626
DDB1 CUL4A â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18931676 19270156 19557001 19622404 19686080 19809470 19847258 20211143
DDB1 DDB2 â—¼   PHYSICAL_INTERACTION 24.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19440234 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
RBX1 DDB1 â—¼   SHARES_COMPLEX 27.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19270156 19440234 19557001 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
DDB1 CUL4A â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18931676 19270156 19557001 19622404 19686080 19809470 19847258 20211143
DDB1 DDB2 â—¼   SHARES_COMPLEX 24.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19440234 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
DDB2 DDB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 54.0 1.0 Omnipath 9418871 17145710 16751180 27203177 22118460 17041588 20368362 18593899 16964240 12050362 19295130 22039351 11564863 16473935 16678110 17392787 24249678 19109893 12151405 26186194 12812979 16949367 18936169 22822215 14751237 10777491 26410533 16260596 19966799 17360488 12732143
RBX1 DDB2 â—¼   PHYSICAL_INTERACTION 24.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19440234 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
RBX1 DDB2 â—¼   SHARES_COMPLEX 24.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18381890 18931676 19440234 19622404 19686080 19809470 19847258 20211143 20457011 22257761 22373527 22615860 22824526 23085398
TP53 DDB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12771027 22336944 15856024 12509284 12170778 16357511 12967652 15927209 11971958
RBX1 ERCC8 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 22466611 24127601 23973375 22466612 20541997 22466610 23906714 16751180 22902626
ERCC8 CUL4A â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 22466611 24127601 23973375 22466612 20541997 22466610 23906714 16751180 22902626
GSK3B FBXO4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 18598945 21242966 19489726 17570479 21113395
RBX1 FBXW7 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15546612 18094723 11585921 11461910 11565034
CDC23 FZR1 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
CDC16 FZR1 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
CDC27 FZR1 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
ANAPC1 FZR1 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
CDC27 FZR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 12797865 12956947 23029392 18662541 9637688 15916961 22014574 21241890 10500174 26963853
FZR1 CDC27 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 12797865 12956947 23029392 18662541 9637688 15916961 22014574 21241890 10500174 26963853
TP53 HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15358769 15284248 24451373 18996350
HSP90AA1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 12427754 10557093 21460846 16713569 11507088
HUWE1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 17145710 15989956 19918835 19960022 19590512
CUL3 KEAP1 â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 15703371 16697054 17312394 17884153 18931676 19560419 19622404 19686080 19809470 19818716 19847258 23030059 23850759
RBX1 KEAP1 â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 15703371 16697054 17312394 17884153 18931676 19560419 19622404 19686080 19809470 19818716 19847258 23030059 23850759
CUL3 KEAP1 â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 15703371 16697054 17312394 17884153 18931676 19560419 19622404 19686080 19809470 19818716 19847258 23030059 23850759
RBX1 KEAP1 â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 15703371 16697054 17312394 17884153 18931676 19560419 19622404 19686080 19809470 19818716 19847258 23030059 23850759
KEAP1 CUL3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 20534351 30273379 15983046 24896564 15282312 17439941 32341456 26219975 32296183 26757824
FGFR3 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
MAPK1 RBX1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 31434245 22955283 12748172 16009132
MAPK1 CUL1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 31434245 22955283 12748172 16009132
MAPK1 SKP1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 31434245 22955283 12748172 16009132
MAP3K1 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 10969079 15315965 17052767 12049732 11971971
MAPK1 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 16039586 28646232 18451303
MAPK1 PML â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 22935031 29416846 23293771 23316480 15093545
MAPK1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 14965474 9765199 15116093 21675959 23443559 10781582 25241761 10446957 10958792 11409876 11709713 21147777 10673501 11551930 15867353 11875057 12091386
TP53 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 201.0 1.0 Omnipath 23150757 20948295 10871862 10914734 21422812 21957016 14532965 22290440 20663877 20547751 11591713 24339722 11840331 22223137 16492744 15843377 22948151 7888679 20156675 21217645 22180176 8319905 9707425 15831521 17690113 9649502 10688649 9194564 15917661 15090541 20837136 8187772 10788589 17907153 15192123 8440237 11964305 16510138 10856296 15580300 7624148 12208736 21211512 16624812 17848574 11245471 21637567 20588255 10562557 9525742 9270029 16479015 19941079 14602726 15024021 18814047 20036872 10718212 18852133 12374749 18397889 25016801 12755686 22081073 22245141 23365201 8957072 22197810 15856024 20703075 23483203 9645455 19648117 20331637 22301280 14743206 23982177 9486848 15734740 19638633 19671680 17310983 10469568 20659896 10072445 21097889 17237821 11748232 11085543 21750655 16337599 21295542 1614537 9815889 9070662 16585169 9472631 17936559 17139261 11328884 12887889 20858413 9858609 14610316 20080970 19505873 11313463 15684615 18359851 18783169 16202543 9267820 12235242 14990790 15851483 7587074 18336191 21478269 17043642 15361831 18025460 23612020 10208414 11756653 24389645 9071998 9430645 9400998 9371494 23149414 22532570 9271120 10777217 22383580 18781178 12606552 14514686 17318220 11127813 16571800 19085961 9207798 10891494 10065155 11593391 14570892 12902982 19649205 20124454 17390010 19955655 12138177 19663772 23581014 15908423 10321740 23150759 19837670 10348346 18632610 9294611 11956627 12750288 12851404 8313378 9135153 15735665 7958853 8247544 9535786 16501602 18566224 8910340 11046142 9405685 7936649 12173040 17329361 21451571 14704432 23874713 18333294 19541936 22787160 18585004 22085928 12080472 7651818 11179471 10949923 19428175 15592502 8413278 11714701 10566557 18583933 9681831 15550242 15007388 19590512
UBE2I MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15169778 15340381 15147722 12820959 10722742 19459846 18006823 10721693 19440234
MDM2 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 559.0 1.0 Omnipath 20657550 30005830 17616658 9529249 10321734 33650658 9724739 24462112 24621507 15933712 23826318 24667498 22948151 22653443 23776060 25313037 25241761 19303885 16857591 23246961 19033382 20591651 21149449 25417702 15122315 16579792 27543608 29670376 12208736 17848574 26673821 25277184 23443559 23318437 21060154 15210108 19805293 8875929 8058315 21471462 17879958 25362358 23169665 22301280 21584881 20124408 10980696 26876197 17310983 17380154 15058298 24567357 18665269 30109812 25637791 18467333 22337874 22227409 22389628 15242646 22510990 15950904 15001357 19483087 26540344 14559824 21986495 26556313 20708156 19901969 33765973 32528731 11562347 10202144 22374672 10722742 22083959 21965653 17098746 19234109 30679555 16107876 12690203 22525275 19071110 28542145 12620407 20837658 27129163 9131587 24240685 27031960 10681559 19305137 11744695 19188367 16023600 24659749 17347673 12944468 20395212 22084066 20639885 21454483 12897156 16432196 10347217 10706102 11178989 20174603 16751805 15542844 12842086 11431470 11384992 25739118 15064742 23402884 27462439 16905769 22124327 27215386 12867035 22588298 27336364 14702041 16152627 23776465 22262183 21132010 19411846 18309296 23483203 11709713 18981217 14612427 22920093 23671280 24980433 27905468 25168242 21750659 26238070 22737255 23609977 27282385 20847049 20705607 21075307 28082682 17297477 11697899 17936559 24361594 19098711 15469934 34591612 24998844 16212962 11094089 12915590 17116689 11713288 15144954 23201157 10608892 17591690 25156994 17301054 22444248 26883110 26001071 19160491 22157679 24413661 19357310 23802716 15280377 21317885 11597128 19579266 25624478 18061646 21088494 9223638 10435614 31177307 11331603 22391559 20570896 19941302 9278461 18485870 15604276 18566590 12612087 11046142 14704432 26186194 10935507 16173922 14596917 17159902 25543083 19656744 15848166 18316739 22266868 17056014 19255450 21561866 19590512 11839577 22991965 22266850 24200963 11285227 11713287 22975381 19081178 20660730 26475964 16678796 23261415 20173098 17666403 25464845 32427887 23252402 17438265 20959462 22659184 17470788 22912717 17080083 15247280 19332559 17989425 16870621 18813780 20235143 11278372 10562557 25609649 10561590 19411066 17908790 19568783 7926727 21925390 21988832 24127580 18604177 14499615 17371838 17525743 33061576 21887275 26578655 21084564 16861890 20694676 12552135 22914926 17363365 24643130 1614537 22916255 12381304 34992144 12167711 19857530 15053879 10889512 11486026 22103682 16713569 17110336 17426254 10640350 21316347 21478269 15154850 12529318 16595680 16414131 19597489 23880345 27893708 7686617 27811966 17318220 29997244 27308622 19166840 35044719 16159876 24314634 15313915 25283148 22032989 24926618 18172499 19837670 16215989 23134341 26908445 9824166 18451149 21170087 23572512 21465263 22807444 15013777 16845383 10488081 23946421 11714701 25384516 22474335 25312347 23370271 23150757 18541670 22318540 11925449 21572037 24488098 32066565 17268548 20542919 11572869 16338390 21857681 23150668 19223463 20234175 20484049 11070080 20591429 22575647 11351297 16624812 22411991 20588255 17369817 11223036 15908921 9582019 25103245 17302414 21071676 9450543 31968249 34562520 18332869 14671306 21084285 27856536 30464405 26882543 21726810 33020477 21261729 21268072 12426395 16964247 20659896 19106616 22331460 23728348 10827196 22524527 21098709 9363941 17139261 20080206 14517261 22487680 31652301 17290220 27106262 16866370 24207125 28223335 9271120 15550400 7689721 26350565 10196247 27807478 10766163 15558054 35371302 26203195 29487367 25512388 25954860 18223694 15824742 24842904 14741215 16055726 22085928 32894144 18234963 17875722 18815136 15295102 15308643 15358376 22819825 15094782
MDM2 UBB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19805293 22056774 17290220
MDM2 PML â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15195100 12759344 14507915 16713569 12915590
SUMO1 PML â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 22875967 9756909 25497731 17036045 21057547 18931695 19217413 8806687 16189514 17081985 11080164 11948183 9885291 19380586 17344210
RNF4 PML â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23028697 18708055 15707587 24907272 18408734 21252943 22388745 24637324 19380586
RAD18 PCNA â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 10884424 15280666 15688063 16611994 16824193 17652783 18157158 18196958 18363965 18498753 19013543 19258535 19396164 20129063 20675655
RAD18 PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 18363965 19706603 17652783 18196958 18498753 20129063 21227930 10884424 19013543 18157158 15280666 19258535 16611994 19396164 20675655
UBE2D3 RBX1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
UBE2D1 RBX1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
UBE2D2 RBX1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
CUL1 RBX1 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
PCNA RBX1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
RBX1 SKP1 â—¼   PHYSICAL_INTERACTION 24.0 1.0 ACSN 11900249 12648680 12820959 14536078 15071497 15147722 15340381 15459660 15489953 15688063 15703371 16697054 17053147 17884153 18636226 18787170 18931676 19150432 19270156 19622404 19686080 19797085 19809470 19847258
RBX1 SKP2 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 11900249 12648680 12820959 15071497 15147722 15340381 15459660 15688063 15703371 16697054 17884153 18931676 19270156 19622404 19686080 19809470 19847258
RBX1 CUL4A â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18931676 19270156 19557001 19622404 19686080 19809470 19847258 20211143
RBX1 CUL3 â—¼   PHYSICAL_INTERACTION 34.0 1.0 ACSN 11583996 11900249 12648680 12820959 14744430 15340381 15459660 15688063 15703371 15760909 16498403 16547521 16697054 17312394 17884153 18545270 18931676 19090789 19427028 19560419 19622404 19686080 19809470 19818716 19847258 20006983 20531300 20599425 23030059 23377657 23845861 23850759 27984721 9242610
RBX1 VHL â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18931676 18985005 19622404 19686080 19809470 19847258
RBX1 CUL1 â—¼   PHYSICAL_INTERACTION 76.0 1.0 ACSN 10023660 10671552 11348595 11900249 11955436 11967263 12051714 12648680 12820959 14536078 15001769 15071497 15147722 15340381 15459660 15489953 15688063 1570337 15703371 16039586 16469695 16697054 16713974 16940750 17053147 17143292 17652783 17884153 17928543 17936032 18196958 18636226 18787170 18805092 18931676 19143635 19150432 19250909 19258535 19270156 19352404 19366350 19411070 19557001 19576224 19597341 19619488 19622404 19686080 19751508 19797085 19809470 19836308 19847258 19849719 20006983 20211143 20558317 20705860 20832730 20843316 20976471 21411632 22270359 22682247 22730322 23343194 23732914 24023259 25730849 26159692 26885856 7542250 7641885 8666229 9694792
RBX1 CUL2 â—¼   PHYSICAL_INTERACTION 21.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18420585 18931676 18985005 19622404 19622774 19686080 19809470 19847258
RBX1 CUL3 â—¼   SHARES_COMPLEX 34.0 1.0 ACSN 11583996 11900249 12648680 12820959 14744430 15340381 15459660 15688063 15703371 15760909 16498403 16547521 16697054 17312394 17884153 18545270 18931676 19090789 19427028 19560419 19622404 19686080 19809470 19818716 19847258 20006983 20531300 20599425 23030059 23377657 23845861 23850759 27984721 9242610
RBX1 CUL2 â—¼   SHARES_COMPLEX 21.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18420585 18931676 18985005 19622404 19622774 19686080 19809470 19847258
RBX1 CUL1 â—¼   SHARES_COMPLEX 76.0 1.0 ACSN 10023660 10671552 11348595 11900249 11955436 11967263 12051714 12648680 12820959 14536078 15001769 15071497 15147722 15340381 15459660 15489953 15688063 1570337 15703371 16039586 16469695 16697054 16713974 16940750 17053147 17143292 17652783 17884153 17928543 17936032 18196958 18636226 18787170 18805092 18931676 19143635 19150432 19250909 19258535 19270156 19352404 19366350 19411070 19557001 19576224 19597341 19619488 19622404 19686080 19751508 19797085 19809470 19836308 19847258 19849719 20006983 20211143 20558317 20705860 20832730 20843316 20976471 21411632 22270359 22682247 22730322 23343194 23732914 24023259 25730849 26159692 26885856 7542250 7641885 8666229 9694792
RBX1 SKP1 â—¼   SHARES_COMPLEX 24.0 1.0 ACSN 11900249 12648680 12820959 14536078 15071497 15147722 15340381 15459660 15489953 15688063 15703371 16697054 17053147 17884153 18636226 18787170 18931676 19150432 19270156 19622404 19686080 19797085 19809470 19847258
RBX1 VHL â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18931676 18985005 19622404 19686080 19809470 19847258
RBX1 SKP2 â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 11900249 12648680 12820959 15071497 15147722 15340381 15459660 15688063 15703371 16697054 17884153 18931676 19270156 19622404 19686080 19809470 19847258
RBX1 CUL4A â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18931676 19270156 19557001 19622404 19686080 19809470 19847258 20211143
RBX1 CUL1 â—¼   ENZYMATIC_REACTION ✅ 76.0 1.0 ACSN 10023660 10671552 11348595 11900249 11955436 11967263 12051714 12648680 12820959 14536078 15001769 15071497 15147722 15340381 15459660 15489953 15688063 1570337 15703371 16039586 16469695 16697054 16713974 16940750 17053147 17143292 17652783 17884153 17928543 17936032 18196958 18636226 18787170 18805092 18931676 19143635 19150432 19250909 19258535 19270156 19352404 19366350 19411070 19557001 19576224 19597341 19619488 19622404 19686080 19751508 19797085 19809470 19836308 19847258 19849719 20006983 20211143 20558317 20705860 20832730 20843316 20976471 21411632 22270359 22682247 22730322 23343194 23732914 24023259 25730849 26159692 26885856 7542250 7641885 8666229 9694792
RBX1 CUL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 154.0 1.0 Omnipath 17053147 12684064 20638939 11967263 19797085 19258535 26540345 18826954 15071497 15448697 21765416 25730849 10230406 23343194 21169563 22270359 19250909 23732914 11359933 12051714 20006983 15361859 10748083 19352404 22682247 18787170 12504025 18636226 16469695 15459660 20211143 10535940 15001769 26725323 19411070 11861641 26159692 16697054 1570337 19751508 22822056 11348595 7542250 7641885 19849719 16759355 12820959 17452440 19622404 15703371 10648623 19245792 23331499 9694792 19150432 23180781 19597341 16189514 22474075 18988627 22767593 17143292 24949976 10713156 23770852 22405651 19942853 18196958 20399188 16713974 26192618 11027288 17884153 19933270 22730322 21411632 11961546 17936032 19809470 15147722 19270156 19576224 11483504 20976471 12504026 24023259 12840033 15340381 12904573 20558317 11900249 14536078 19686080 12565873 18805092 15489953 19557001 26885856 17652783 12481031 20843316 11955436 21071413 16039586 11956208 20705860 8666229 17928543 10023660 19836308 16940750 12706828 19143635 15688063 10671552 16123592 19366350 19847258 12417738 11245432 20832730 12648680 12609982 19619488 10230407 18931676
SHPRH PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 19706603 17652783 18196958 19851286 16789823 18719106 18525240 18647995 18157158 10880451 19258535 16224103 20675655 16518696
SUMO1 SAE1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 9920803 20164921 19107418 10187858 11481243 20501649
UBE2I SUMO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 47.0 1.0 Omnipath 21212807 25416956 16713569 18691969 17938407 11735126 25502805 15931224 26496610 16732283 24352468 17353931 18359863 10666456 21174150 8921390 9353268 12924945 21949651 32296183 16524884 17956732 18264111 12764129 10961991 14673145 19684601 17698038 16494873 31515488 23871147 17491593
PIAS1 SUMO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16524884 22578841 19217413 18806873 14609633 11583632
PIAS2 SUMO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 16204249 21988832 25416956 19217413 16189514 14609633 16524884 12764129
TP53 CDK5 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 10604467 17591690 12064478 18490454 10500146
TP53 PCNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 10321841 7915517 15358233 12217864 10516009 1705714 8570655 16980608 9707425 15950182 19789303 11313928 1356162 12384701 9858527 12947108 23390122 8524244 9651310 1352831 7909518 11032828 10910968 12485898 10618724
TP53 CASP6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 19897582 16391794 18064040 16518869 12089322 24070868
TP53 COP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19837670 15492238 15861129 15103385 21403399
TP53 SIAH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 20181957 20421190 14985507 11852084
TP53 MAPK8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 22607268 23376463 18374905 15958553 10854211 22353755
UBE2D1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15169778 15340381 15147722 12820959 10722742 19459846 18006823 10721693 19440234
RCHY1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 21988832 19483087 17568776 24367557 25116336 21084285 12654245 21791603 20452352 19043414 16713569 31630802 27519799 19918835
PIAS1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 25241761 15133049 10380882 20805487 11867732 16713569 11583632 11788578
GSK3B TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 23840442 12064478 11709713 9372954 11483158 16552184 17570479 14744935 16713569 21929745 12048243 21900206
UBE3A TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 25.0 1.0 Omnipath 23040663 7724550 9450543 16713569 16493710 15001357 17131388 9143503 19364824 31971989 11027293 9688277 9369221 1661671 7708685 12620801 8090726 8380895 26789255
MAPK8 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 37.0 1.0 Omnipath 11108663 12531896 16713569 11283254 10706102 19651615 27147566 9724739 15538975 9732264 10581258 10436023 17570479 9393873 11896587 12514174 15580310 18813780 11078726
CDK5 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 44.0 1.0 Omnipath 9372954 21317932 11483158 11740489 19413330 19664995 21600237 11554766 11709713 16552184 10884347 16377624 17591690 15866171 17287340 17967874 92065884 11780126 12064478 10570149 26146988 15701641 17117479 17108107 14702041
TP53 COP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16713569 23736031 15103385 18431400
TP53 SIAH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12077306 12438652 14985507 15326481
TP53 UBB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 18172499 18695251 24667498 22056774 17290220 17592138 12421820 18413597 20173098 19556538 21857681 17470788 18359851 19805293 19196987 12640129
TP53 CASP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18431400 12089322
TGFBR2 TRAF6 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 11013220 11133108 12154066 12717440 12724770 12767520 12809600 14557817 15265520 15548370 16474430 17673906 17934056 18758450 18922473 19010789 19050695 19109155 19920116 20060931 20519943 20644162 21278795 21614932 21900405 22703233 22710166 22943793 24132110 24336330 7594497 9865696
TGFBR2 TRAF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 50.0 1.0 Omnipath 12717440 19050695 11133108 14557817 19920116 22710166 19114990 12767520 22703233 23331499 11013220 20060931 17934056 21614932 17673906 20644162 24132110 18922473 9865696 22943793 20519943 21900405 12154066 7594497 18758450 15548370 24336330 21278795 12724770 19010789 15265520 16474430 26192618 12809600 19109155
UBE2N TRAF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 18710948 1551980 17327397 11057907 15147900 18981220 21113135 17709375 31074699 19549727 18617513 24610907 27791197 29432170 19465916 23885119 15327770 27173435 21872579 25548215
TRAF6 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10346818 17965022 15692051 17947236
UBE2L6 UBA7 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11157743 15485925 18583345 15131269
UBE2A PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 18363965 10884424 12820959 19459846 19258535 19440234 17652783 15147722 15169778 19706603 18498753 12226657 20129063 10722742 18006823 18157158 16611994 20675655 18196958 15340381 19013543 15280666 19396164 10721693
VHL UBE2D3 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
PEX2 UBE2D3 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 21554508 19208625 17726030 18359941 10562279
UBE2D3 CUL2 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
UBE2D3 ELOC â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
UBE2D3 ELOB â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
UBE2N PCNA â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 10880451 16224103 16518696 17652783 18157158 18196958 18525240 18647995 19217833 19258535 19851286 20675655
UBE2N PCNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 18772547 12820959 18525240 19459846 19258535 19440234 17652783 15147722 10880451 15169778 19851286 10722742 18647995 18006823 18157158 16224103 20675655 16518696 18196958 15340381 10721693
PCNA CUL4A â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17720710 12226657 18342608 20129063
UBE2M CUL4A â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 19617556 18826954 25349211 26460955 25314029 18206966 23201271 26906416 19250909 25531226 26344709
UBE2D1 CUL2 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
UBE2D2 CUL2 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
CUL2 VHL â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18931676 18985005 19622404 19686080 19809470 19847258
CUL2 VHL â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18931676 18985005 19622404 19686080 19809470 19847258
PEX2 UBE2D1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 21554508 19208625 17726030 18359941 10562279
VHL UBE2D1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
UBE2D1 ELOC â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
UBE2D1 ELOB â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
UBE2D1 MGRN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19549727 17229889
RNF40 RNF20 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21362549 16307923 19410543
RNF20 RNF40 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21362549 16307923 19410543
SMURF1 TGFBR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 11278251 15221015 22298955 15761148 21572392 27048878 22949611
PLAU PLG â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 18633355 20027185 22470492 27216177
CDC20 BUB1 â—¼   PHYSICAL_INTERACTION 21.0 1.0 ACSN 10477750 11402067 11535616 12640463 15024386 15279786 15592459 17303408 17376779 17498870 17660363 18022367 18590585 19154723 19182530 19503101 21270334 23197039 7575488 8824189 9790499
BUB1 BUB3 â—¼   PHYSICAL_INTERACTION 21.0 1.0 ACSN 10477750 11402067 11535616 12640463 15024386 15279786 15592459 17303408 17376779 17498870 17660363 18022367 18590585 19154723 19182530 19503101 21270334 23197039 7575488 8824189 9790499
CDC20 BUB1 â—¼   SHARES_COMPLEX 21.0 1.0 ACSN 10477750 11402067 11535616 12640463 15024386 15279786 15592459 17303408 17376779 17498870 17660363 18022367 18590585 19154723 19182530 19503101 21270334 23197039 7575488 8824189 9790499
BUB1 BUB3 â—¼   SHARES_COMPLEX 21.0 1.0 ACSN 10477750 11402067 11535616 12640463 15024386 15279786 15592459 17303408 17376779 17498870 17660363 18022367 18590585 19154723 19182530 19503101 21270334 23197039 7575488 8824189 9790499
BUB1 CDC20 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 18995837 26912231 26811472 18767875 21439394 19413330 15525512 18669648 25669885
BUB1 BUB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 21988832 26186194 26148513 20220147 20057499 25416956 16760428 26496610 11283619 11402067 16189514 9660858
CDC20 BUB3 â—¼   PHYSICAL_INTERACTION 21.0 1.0 ACSN 10477750 11402067 11535616 12640463 15024386 15279786 15592459 17303408 17376779 17498870 17660363 18022367 18590585 19154723 19182530 19503101 21270334 23197039 7575488 8824189 9790499
CDC20 CDC27 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
CDC20 BUB3 â—¼   SHARES_COMPLEX 21.0 1.0 ACSN 10477750 11402067 11535616 12640463 15024386 15279786 15592459 17303408 17376779 17498870 17660363 18022367 18590585 19154723 19182530 19503101 21270334 23197039 7575488 8824189 9790499
CDC27 CDC20 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 25156254 12956947 9736712 17443186 22014574 9637688 24781523 16189514 14561775 12196507
CDC20 CDC27 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 25156254 12956947 9736712 17443186 22014574 9637688 24781523 16189514 14561775 12196507
CDC20 ANAPC11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 25241761 27509861 18997788 26387737 9734353
UBE2M CUL1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 16647857 19617556 18826954 25349211 25314029 18206966 21940857 23201271 26906416 19250909 25531226 21863050
CUL1 SKP2 â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 11516665 11900249 12648680 12820959 15071497 15147722 15340381 15459660 15668399 15688063 15703371 16697054 17884153 18931676 19270156 19622404 19686080 19809470 19847258
CUL1 SKP1 â—¼   PHYSICAL_INTERACTION 26.0 1.0 ACSN 11516665 11900249 12648680 12820959 14536078 15071497 15147722 15340381 15459660 15489953 15668399 15688063 15703371 16697054 17053147 17884153 18636226 18787170 18931676 19150432 19270156 19622404 19686080 19797085 19809470 19847258
CUL1 SKP1 â—¼   PROTEIN_INTERACTION 1.0 1.0 HIPPIE 14685242 16189514 17290223 20832730 12504025 12904573 10230407 19933270 23324393 12504026 9636170 26540345 12609982 27697867 26753747 21145461 22474075 28007894 18818696 9736735 9990852 22767593 28152074 10023660 29070679 9827542 23951410 16357137 16759355 10713156 15452136 19270694 11027288 26474281 23770852 10648623 29499133 21249194 34499862 12628165 15966899 21169563 22660580 11961546 9430629 32313199 29863914 10230406 30653357 19945379 9663463 21778237 34237211 18094045 26976582 27705803 32249768 29103612 33961781 12684064 26725323
CUL1 SKP2 â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 11516665 11900249 12648680 12820959 15071497 15147722 15340381 15459660 15668399 15688063 15703371 16697054 17884153 18931676 19270156 19622404 19686080 19809470 19847258
CUL1 SKP1 â—¼   SHARES_COMPLEX 26.0 1.0 ACSN 11516665 11900249 12648680 12820959 14536078 15071497 15147722 15340381 15459660 15489953 15668399 15688063 15703371 16697054 17053147 17884153 18636226 18787170 18931676 19150432 19270156 19622404 19686080 19797085 19809470 19847258
UBE2M CUL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 24949976 10713156 17914462 21247897 18805092 21946088 19245792 18826954
SKP1 CUL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 66.0 1.0 Omnipath 9663463 19945379 12684064 19270694 16759355 23951410 10648623 11961546 26540345 26976582 26474281 17290223 9736735 21169563 14685242 16357137 21145461 29070679 15452136 15966899 12628165 21778237 22474075 16189514 22767593 11359933 9430629 10713156 10023660 10228155 12504026 18818696 9827542 12504025 18094045 10066435 23324393 23770852 9990852 12417738 27705803 9636170 21249194 12904573 34499862 11027288 26725323 20832730 19933270 12609982 10230407
CUL1 RNF7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11506706 10851089 10230407 16189514
UBE2M SKP1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 16647857 19617556 18826954 25349211 25314029 18206966 21940857 23201271 26906416 19250909 25531226 21863050
BTRC SKP1 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
SKP1 SKP2 â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 11516665 11900249 12648680 12820959 15071497 15147722 15340381 15459660 15668399 15688063 15703371 16697054 17884153 18931676 19270156 19622404 19686080 19809470 19847258
SKP1 SKP2 â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 11516665 11900249 12648680 12820959 15071497 15147722 15340381 15459660 15668399 15688063 15703371 16697054 17884153 18931676 19270156 19622404 19686080 19809470 19847258
FBXW11 SKP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 17145710 25609649 10321728 25900982 15070733 12165731 10230406 21145461 26496610 24500709 10023660 10066435 25332235 19615732 19159283 27705803 10644755 25515538
RHOBTB1 CUL3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 31431478 31871319 18835386 30896450
UBE2M CUL3 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 19617556 18826954 25349211 23912815 25314029 18206966 21940857 23201271 26906416 19250909 30610225 25531226
MAP3K1 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 12228228 9405400 25241761 10465784 15757900 15299005 14500727 21152872 26538579
SERPINF2 PLG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 3334852 134998 158022 2437112
CDK5 PRKN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 19399218 24486837 17327227 19050041 29899409
MAPK8 ITCH â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 23435430 16469705 15358865 16446428
VHL UBE2D2 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
BIRC2 UBE2J1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 19690564 28321712 15861135
UBE2I UBE3A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15340381 12820959 18997815 15668399 18298802
UBC PRKN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 24784582 26162776 26161729 25847540 24751536 26254304 23670163 26116755 27284007 25474007 26260794 22724072 25969509 24856362
ANAPC2 CDC27 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17145710 10922056 10500174
ANAPC10 CDC27 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11524682 10500174
CDC16 CDC27 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 17145710 9405394 17187060 24100295 7736578 21043528 10922056 26496610 9356466 25306918 12956947 20733055 22193957 27114510 16648845 9628895 14657031 20360068 16364912 10500174
CDC27 ANAPC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17145710 10922056 10500174
CDC27 CDC16 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 17145710 9405394 17187060 24100295 7736578 21043528 10922056 26496610 9356466 25306918 12956947 20733055 22193957 27114510 16648845 9628895 14657031 20360068 16364912 10500174
CDC27 ANAPC10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11524682 10500174
MAPK8 CTBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 28532298 14567915 17496919 19591900 21372320 19788416 15708980 8608010 16984892 20512932 20220133 21438496 20054826 19616017 23762064 15611655
ANAPC10 ANAPC2 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
ANAPC2 CDC23 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
ANAPC11 ANAPC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12956947 24163370 11739784 10230407
ANAPC2 ANAPC11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12956947 24163370 11739784 10230407
ANAPC2 UBE2C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 25825779 16189514 11739784
CDC26 CDC16 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 21988832 20360068 25416956 25723520 31515488 26496610 32296183 19668213
CDC16 CDC26 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 21988832 20360068 25416956 25723520 31515488 26496610 32296183 19668213
ANAPC4 CDC23 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
ANAPC10 ANAPC4 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
UBE2E1 RNF167 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19690564 23414517 16314844
UBE2M UBA3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 25531226 15361859 19250909 17220875
PEX2 UBE2D2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 21554508 19208625 17726030 18359941 10562279
UBE2D2 ELOC â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
UBE2D2 ELOB â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
UBE2L6 HERC5 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 16407192 17289916 16815975 16352599