Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
ABL1 DNM3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ABL1 PPP3CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ABL1 NEK8 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ABL1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11753601 9916993
ABL1 PARK7 â—¼   CLEAVAGE ✅ 2.0 0.8 intact 23831022 8433088
ABL1 PLK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 27899378
MYC AIMP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11085504
SQSTM1 BAG3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7263374 19229298
SOD1 BAG3 â—¼   COLOCALIZATION 2.0 0.8 intact 8141566 21252941
BAG3 SQSTM1 â—¼   COLOCALIZATION 2.0 0.8 intact 7263374 19229298
BAG5 HSPA1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20223214 15603737
CDC37 TBK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
CDC37 SQSTM1 â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 21900206 2001699 8089645
FGFR3 CDKN1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
AKT1 CDKN1A â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12244303 11231573
AHR CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12203118 24431146
PPARG CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15041706
DNAJC7 SMAD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
FOXO1 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16670091 19289458
FOXO1 MCM5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17609436
PRMT5 HSF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HSF1 CAMK2A â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15760475 11447121
HSF1 HSPA1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9869631
PPP2R1A HSPD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8208439 17540176
FGFR3 HSPD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HSPD1 FADD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
HSPD1 FLCN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
HSPD1 NLRP3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
MYC HSPD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10737792
SRC MAPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16580177 9924018
MAPK3 SQSTM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7717053 20154642
MAPK3 ARRB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16580177 9924018
MAPK3 RPS6KA1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12832467 16626623
MAPK3 PARP1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 0508606103 16627622
MAPK3 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16888388 16691505
MAPK3 METTL3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 33217317
MAPK3 MYLK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15310280 10402467
MYC FGFR3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
MYC CASP6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
AHR MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11114727 16091746
RFX1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10918054 12032779
MYC PRKACA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15197457 12420224
MYC HERC5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11983916
MYC EZH2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21941025 19197161
MYC HSPA9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11983916
MYC PMAIP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18042711 22216287
MYC CD4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 1321339 11266125
AKT1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17942906 9804616
MYC PMAIP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15856024
OLA1 PRMT5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
HSPB1 OTUB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
OTUB1 ATXN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
OTUB1 SOD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
OTUB1 SNCA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SNCA PARK7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0020362 15502874
PPP2R1A PARK7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8208439 17540176
PARP1 NADSYN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
PARP1 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18314489
PLK1 TUBG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10191277 16189514
SMAD1 PSMD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
PRKACA PSMD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SMAD2 SNAI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19389392 18618014
SMAD4 SNAI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18618014 18832382
HIF1A SNAI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23979441 23496980
SQSTM1 ATXN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SQSTM1 SNCA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
NFKB1 SQSTM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9762895
SQSTM1 SOD1 â—¼   COLOCALIZATION 2.0 0.8 intact 8141566 21252941
CAMK2A STUB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
STUB1 POLB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18313385
STUB1 MKKS â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18094050
STUB1 SMAD5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22298955 21454478
STUB1 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19940151 25637186
HSPB1 UBE2N â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18950704
LATS2 YAP1 â—¼   PHOSPHORYLATION ✅ - 0.8 0.8 Signor 22658639
YAP1 TEAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11358867 23431053
HIF1A ARC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22475487 24344197
ATXN1 CDK6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16713569 5218676
RELA CDK6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18504428
E2F8 CASP6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
E2F8 SNCA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
E2F8 FGFR3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HSPA1L RIPK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
MYH9 CHUK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
MYH9 MYLK â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 3079756 3839510
ARRB1 GNAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23353685
SMAD5 SMAD4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD4 RFX1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD4 AHR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11259615
EIF4E SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12150994 23331499
MAP2K7 MAP3K7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219344 17110930
HSPA5 RIPK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSPA9 RIPK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
RIPK1 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18949366 24323043
PPP2R1A SMAD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD2 RUNX2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15599395 9812998
SMAD2 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21836474 21926264
CAMK2A SMAD3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PRKACA SMAD3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SMAD3 CHUK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0712044105 18268325
SMAD3 PPP2R1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD3 AHR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11259615
SMAD3 RUNX2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11331591 21612856
EIF4E SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12150994 23331499
SMAD3 FOXP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19701891 15367216
HIF1A PTEN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18340011 19648120
EZH2 PTEN â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 24719098 22956625
RELA PTEN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 14729949
POT1 DAXX â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20211137 20651253
MAP3K5 DAXX â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 11003656 5213028
HSPA9 CHUK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
FGFR3 RELA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RELA CASP6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RELA EPAS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20495570
PRKCZ RELA â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 12881425 5216561
PPARG ESRRA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20519122 15821111
PPARG NOS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10848596
HSPB1 MAP3K5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
MAP3K5 MAP2K7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219344 17110930
HIF1A ESRRA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0711677105 18509053
HIF1A HSPA1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19335985 18844219
HIF1A PKM â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19828020
SENP3 HIF1A â—¼   COLOCALIZATION 2.0 0.8 intact 7941484 19680224
HIF1A PKM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15379897 8089148
SRC ERBB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6731430 11940572
SRC ARRB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16432186 0510562103
SRC AXL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22327215 8381689
SRC PTK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6672010 16291744
CAMK2A AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ATXN1 AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PRKACA AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ESR2 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16549430 17261755
NFKB1 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 18031796
PRKCZ AKT1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 18650932 7232391
MAPK8 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16306447
AKT1 SP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21619873 21777568
TAL1 NFKB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16778171
NFKB1 MYLK â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18363837 16474009
PRKCZ NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11684013 12881425
AGO2 FGFR3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
FGFR3 PKM â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PRKCZ MAPK10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18667433 17646398
TEAD3 CTBP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
RFX1 SMAD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD1 SMAD5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD1 RUNX2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19664780 24692107
SMAD1 RUNX2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17215250 22298955
TUBA1A HDAC6 â—¼   DEACETYLATION ✅ 2.0 0.8 intact 5215415 12024216
LLGL1 ACD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
NR3C2 INSR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8675013 12767279
PA2G4 HSPA5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
PA2G4 ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath
PRKACA ATXN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PRKACA AQP2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12194985 9227644
PRKACG AQP2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12194985 9227644
CTNNB1 CASP6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CTNNB1 AHR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19651607 0902132106
MAPK10 ARRB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19782076 7263131
SOD1 PPP3CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16189514 11513882
PDLIM5 ATXN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
NEK8 ATXN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
AHR HSPB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 14973392 11174852
HSPA9 TBK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
AHR NQO1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19138946 21569840
CASP6 SNCA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SNCA DNAJC5 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
HSPA5 TBK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
AGO2 EZH2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19955415 0912384106
PRMT5 CLK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 23455924 8417751
AGO2 AGO1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16756390 0040210
RUNX2 LEF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20890621 19650108
LEF1 RUNX2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16575901 16043491
CDK18 AQP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 32164329
UBE2D1 OTUB1 â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 8379996 22124327
PTEN PTK2 â—¼   DEPHOSPHORYLATION ✅ - 0.81 0.81 Signor 10400703
OTUB1 UBE2D1 â—¼   PHYSICAL_INTERACTION 817.0 0.81 STRING 36370105
OTUB1 UBE2D3 â—¼   PHYSICAL_INTERACTION 817.0 0.81 STRING 36370105
OTUB1 BAG6 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 32814053 26752685
RIPK4 CDC37 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 29435596 26972000
CDC37 ERBB2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 25036637 24189400
BAG4 HSF1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
MYC CTBP2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 30415952 29467282
MYC BCR â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17314511 32140074
MYC PCBP1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17314511 29467282
MYC ASPM â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21150319 29467282
ESR2 PSMD2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 29509190 25604459
BAG4 YAP1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
NFKB1 DPM1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 25609649 27609421
SMAD1 LEF1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 10890911 15750622
ARRB2 RFX1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
PCBP1 CDC37 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
MYC ERCC3 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 33381997 17314511 29467282
FOXO1 PRKACG â—¼   PHYSICAL_INTERACTION 829.0 0.83 STRING 36370105
HSPB1 HSF1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 25036637 19597476
PLK1 HSF1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 18794143 27173435
MAPK3 HSPB1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 25241761 21575178 8774846
MYC HSPB1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 21150319 17314511 29467282
MYC DPM1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 21150319 17314511 29467282
MYC PSMD2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 21150319 17314511 29467282
PARP1 SNAI1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 29331416 21577210
PLK1 TBK1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 25659891 33961781
ESR2 PSMD1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 29509190 21182203 25604459
MLF1 RIPK1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
ARRB2 SRC â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 19202075 19122674 11877451 23242524
AKT1 CDKN1A â—¼   PHOSPHORYLATION ✅ + 0.83 0.83 Signor 31575057
MAP3K5 DAXX â—¼   PHOSPHORYLATION ✅ + 0.83 0.83 Signor 19789335
PARK2 PARK7 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
MAP3K7 RIPK1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
CTNNB1 SMAD3 â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
CTNNB1 PPARG â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
IRAK1 CDC37 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 32707033 15647277
MYC HIF1A â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 28628118 15071503 28205554
SMAD1 SMAD3 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 9111321 15761153 18729074
ARRB1 SRC â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 33844281 19202075 16432186 23242524
RUNX2 SMAD1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 10531362 10962029 17215250 20851880
RUNX2 HDAC6 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 12391164 23618908
SMAD5 ACVR1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 10652350 16189514 10583507 9748228
IRAK1 MAP3K7 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
ARRB2 SRC â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
DAXX HSF1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 20620219 15016915
LATS2 SNAI1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 24157836 21952048
AKT1 PTEN â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
RUNX2 SMAD1 â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
SMAD4 SMAD5 â—¼   PHYSICAL_INTERACTION 853.0 0.85 STRING 36370105
AKT1 FOXO1 â—¼   PHOSPHORYLATION ✅ - 0.85 0.85 Signor 21798082
AKT1 FOXO1 â—¼   RELOCALIZATION ✅ - 0.85 0.85 Signor 18423396
CHUK RELA â—¼   PHOSPHORYLATION ✅ + 0.85 0.85 Signor 10521409
ABL1 ERBB2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 22973453 16273093 19275932
CDK18 BAG6 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 26496610 23602568
ESR2 MYH9 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 25604459 21951318
AKT1 SMAD2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16362038 24412244
AKT1 PTEN â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 12297295 19903340 12077256 28628118 20605778 28205554 10866658 20596030
HDAC6 ERBB2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 20029029 31980649
SMAD5 RUNX2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 10531362 22966907
HSPA9 HSPD1 â—¼   PHYSICAL_INTERACTION 862.0 0.86 STRING 36370105
AKT1 PRKCZ â—¼   PHYSICAL_INTERACTION 865.0 0.86 STRING 36370105
BAG3 HSF1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 27173435 23824909 25036637
AKT1 CDC37 â—¼   PHYSICAL_INTERACTION 869.0 0.87 STRING 36370105
BCR ERCC3 â—¼   PHYSICAL_INTERACTION 869.0 0.87 STRING 36370105
MYC CDK6 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 22094256 28628118 28205554
UBE2D3 OTUB1 â—¼   PHYSICAL_INTERACTION ✅ 0.87 0.87 mint 8379996 22124327
PARK7 DAXX â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 15983381 32814053
PARP1 NFKB1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 16204234 11590148 25609649 16799643
CARD11 MAP3K7 â—¼   PHYSICAL_INTERACTION 869.0 0.87 STRING 36370105
SMAD5 SMAD4 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 10531362 16516194 16189514 15231748
PTEN OTUD3 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 26280536 33543443
HSPB1 DAXX â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 15911090 25241761 11193028 11003656 31615977
IKZF1 CTBP2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 32296183 25416956 33961781 21516116
CDC37 CHUK â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
CDK6 CDKN1A â—¼   PHOSPHORYLATION ✅ - 0.87 0.87 Signor 16508017
FOXO1 PRKACA â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
FZR1 PLK1 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
AKT1 CHUK â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
PARK2 SNCA â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
ARC S100P â—¼   PHYSICAL_INTERACTION 0.87 0.87 HuRI 32296183
CHUK MAP3K7 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
AIMP2 PARK2 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
HDAC6 SQSTM1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
DAXX MAP3K5 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
PTEN PTK2 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
CHUK RELA â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
HSPB1 BAG3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 25036637 30559338 26496610 32814053 25277244
CDC37 AKT1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 22504172 12176997 31980649 24869908
CDC37 CLK3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 32707033 33961781 24189400
MYC PLK1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 27773673 17314511 33494392 29467282 30415952
EZH2 SNAI1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 21685935 24903147 18519590
YAP1 CTNNB1 â—¼   PHYSICAL_INTERACTION ✅ 0.88 0.88 mint 22234184 8383887
LATS2 YAP1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 18640976 21041410 25670202 34404733 30865227 33368671 18413746 18565851 26578655 28205554 28754671 25751139 19797269 30472188 29183995 28628118 21832154 25796446 22863277 26598551 21041411 30266805 19919647
MYH9 S100P â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 31837246 15171681
SMAD2 LEF1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10890911 15750622
SMAD2 SMAD1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 9111321 28628118 18729074 28205554
SMAD3 LEF1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10890911 15750622
SRC ESR2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 12095943 12630920 15604093 11013076 11032808
ACVR1 SMAD1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16189514 10583507 10652350 9748228 28847510 10085121 9136927
OTUB1 UBE2D2 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
HDAC6 TUBA1A â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
PARK2 UBE2D2 â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
HSPA5 SQSTM1 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
PARK2 UBE2N â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
AKT1 FOXO1 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
HIPK2 DAXX â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 19465479 14678985 23536002
UBE2D2 OTUB1 â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 8379996 22124327
CTNNB1 YAP1 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
SMAD1 YAP1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 19914168 21685363
YAP1 TEAD3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 27684187 25751139 25796446 26933062 35140242 24255178 24366813 11358867
RIPK1 FADD â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11854271 23972990 24098568 33469115 11002422 26733177 19524513 26865630 32296183 22864571 27560715 23744296 32024820 21183682 30561431 21052097 19373245 24577083 21458669 21737329 32707033 21525013 22848449 29497034 33961781 26186194 26972597 21620750
HIF1A SMAD3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 12228247 28471448 11486006 14741200
SMAD3 RUNX2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10531362 10962029 21986102
AKT1 HSPB1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17510053 31980649 12740362 11042204 23397142
PARK2 UBE2D3 â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
ERBB2 SRC â—¼   PHYSICAL_INTERACTION 898.0 0.89 STRING 36370105
SRC ABL1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11494128 17474147 12522270 11781820 17318191
ABL1 BCR â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12543778 1712671 8112292 21653319 11780146
MYC ABL1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21400515 23029531 19602047
ABL1 HIPK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 26546517 25944899
AIMP2 PPP2R1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CDC37 SRC â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 32707033 33961781 31980649 11085988
CDC37 CDK6 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 25036637 24292678 9150368 8666233 33961781
TUBA1A CDKN1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
PKM CDKN1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
OTUB1 CDKN1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CDKN1A UBE2D1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CDKN1A TUBB3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
SMAD1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19819988 11786386
BCR ERCC3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 17643375 9874796 33961781 10403766
FOXO1 RUNX2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21471200 21281751 20650891
HIPK2 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 12874272
SMAD2 MYC â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11804592 28628118 28205554
SMAD1 MYC â—¼   DOWN_REGULATES ✅ - 3.0 0.9 ACSN 15576399 22290435 22761862
MYC POLB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC SIM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16846534 16489011 18562319
MYC INSR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC SQSTM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
NFKB1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 2191300 18490439 19219071
RELA MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12027803 16713569
OTUB1 UBE2N â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 24071738 30718280 32049508 22367539 25872870 26752685 27173435 27909234 19615732 20725033 22679021
MAPK6 PLK1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
SIRT6 UBE2D1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
RELA SNAI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18477483 19538137 17665043
SQSTM1 IRAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12034707 10747026
UBE2D3 TUBA1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
UBE2N HERC5 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16112642 16428300 16122702
UBE2N MAP3K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17965022 17079228 10702308
YAP1 RUNX2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31496812 25751140 32220262 27684187 10228168
YAP1 LATS2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 17974916 21832154 21205866
YAP1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23607968 22234184 23245941
YAP1 RUNX2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 14765127 22153608 10228168
MAP3K7 CARD11 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 17158449 15327770 10882101
CHUK CARD11 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 19909372 16301747 16356855
SMAD2 SMAD4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9111321 25514493 11927552 28443643 21988832 20211142 15467747 12732634 25609649 15922743 12419246 9288972 21454478 19139564 24157709 18729074 22442258 17283070 16916642 15350224 17591701 11274206 15761153 31591477 26555259 9892009 9311995 10085121 9389648 10781087 12167862 10878024 18783722 27703004 18511908 28468752 19135894 10531362 12794086 15231748 21297662 12621041 19917253 11027280 24584437 16751102 31932471 10199400 21532621 12808092 33961781 11264182 11102446 11114293 12543979 23788427 15817471
AKT1 SMAD4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16362038 23397142
SMAD1 SMAD4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9111321 17183365 16189514 32296183 31467278 12167862 14701756 12874272 28468752 15761153 24412244 10531362 15231748 11700304 11779505 26555259 9436979 21454478
SMAD3 SMAD4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9111321 16189514 25514493 11927552 28443643 21988832 20211142 15084259 12732634 19768112 15467747 20142324 25609649 15922743 12917407 12419246 20564330 24382352 19139564 32296183 24157709 18729074 22442258 10092624 17283070 15350224 17591701 15761153 31591477 10995777 26555259 9892009 9311995 15588252 12167862 10878024 25910212 27703004 33990575 28115363 18055455 22310290 19135894 10531362 12794086 15231748 21297662 22045334 19917253 24584437 27107012 29892012 29997244 21532621 27845895 21597466 25502805 11114293 12543979 23788427
MAP3K7 MAPK6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
MAP3K7 EZH2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
MAP2K7 MAP3K7 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 15837794 8533096 16186825
MAP3K7 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9380693
SMAD2 SMAD3 â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
SMAD2 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18729074 9111321
AKT1 SMAD3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16362038 25241761
TBK1 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10783893 21138416
RELA S100A6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12859951 18753141
RELA NQO1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9058597
SMAD1 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23071089 12589053 16580992
HIF1A PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18461556 19490906 11879638
ARRB1 MAP3K5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19782076 19306926
NFKB1 HIF1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18498249 17898080
HIF1A TUBB3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18178340 21176881
HIF1A NOS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9486205 7500013 7508926
SRC ERBB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 22973453 11940572 17875712 19372587 21075308 29720121 7542762 7797556 19704002
SRC PPP2R1A â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 15637081 15004239 15564375
NFKB1 NQO1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9058597
TAL1 PTK2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20028976
CAMK2A PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15845548
MAPK6 TUBA1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
MAPK6 PPP2R1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
CTNNB1 RUNX2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16575901 16043491 24692107
ARRB2 ARRB1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 24069330 17353931 33961781 17620599
MAP2K7 MAPK8 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16186825 9162092 17875933
ERN1 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18471544 27009865
MAPK6 CASP6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
TAL1 PPP3CA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20028976
AGO1 AGO2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16756390 24086155 24778252 33961781 15908945 29395067
TAL1 NOS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20028976
TAL1 RBFOX3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20028976
MAP2K7 MAPK10 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16186825 9162092 17875933
MYOCD MYLK â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24252873 16260603 16407417
CDK6 CDKN1A â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
PRKCZ SQSTM1 â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
TEAD3 YAP1 â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
PSMD1 PSMD2 â—¼   PROTEIN_INTERACTION 0.92 0.92 HIPPIE 22863883 33961781 28292943 22939629 26344197
AKT1 ARRB2 â—¼   PROTEIN_INTERACTION 0.92 0.92 HIPPIE 18191226 19122674 19262695
PTK2 SRC â—¼   PHYSICAL_INTERACTION 931.0 0.93 STRING 36370105
LLGL1 PRKCZ â—¼   PHYSICAL_INTERACTION 931.0 0.93 STRING 36370105
FOXP3 SMAD3 â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
BAG5 HSPA1B â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
AKT1 FOXO1 â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 10358075 25241761 10358014 16076959 31844113 18786403
SMAD4 SMAD1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 17183365 5219486
ERN1 HSPA5 â—¼   PHYSICAL_INTERACTION 952.0 0.95 STRING 36370105
AKT1 MAP3K5 â—¼   PHYSICAL_INTERACTION 953.0 0.95 STRING 36370105
SMAD1 SMAD4 â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
TUBA1A TUBB3 â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
CHUK NFKB1 â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
STUB1 UBE2D3 â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
STUB1 UBE2D2 â—¼   PHYSICAL_INTERACTION 968.0 0.96 STRING 36370105
MAP2K7 MAPK8 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
GUCY1A3 GUCY1B3 â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
CTNNB1 LEF1 â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
SMAD1 YAP1 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
OTUB1 UBE2N â—¼   PHYSICAL_INTERACTION 980.0 0.98 STRING 36370105
STUB1 UBE2N â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
LATS2 YAP1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
FADD RIPK1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
PSMB2 PSMD1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
PSMD1 PSMD2 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
PSMD14 PSMD2 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
ACD POT1 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
PSMD1 PSMD14 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
PSMB2 PSMD14 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
PSMB2 PSMD2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
STUB1 UBE2D1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ABL1 YAP1 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 10837221 11804596 11971963 12628935 12709442 15459660 18835194 19788416 21051857 21199784 21435002 9168117
SRC ABL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 44.0 1.0 Omnipath 19901323 10964922 16497976 20841568 16787943 17570479 17318191 11847100 10500097 12522270 18691976 11494128 11781820 16076903 20168609 12748290 16464493 12445832 19369195 17474147
RFX1 ABL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9583676 23331499
ABL1 BCR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 9407116 10405761 12522270 11780146 8622703 9178913 1712671 12124177 7529874 9467953 8955135 20841568 8112292 16912036 12543778 11376433
ABL1 MYLK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 20861316 11113114 12408982
ABL1 YAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 25361080 19788416 21199784 29449692 18955976 21051857 18280240 21435002 18701449 27807512 20841568 21214929 21945154 29179447 15459660
ABL1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 16099633 25164010 17618275 24465953 20841568 17318191 20840866
ABL1 ERCC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 9874796 20841568
ABL1 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 30323259 25368164 26385316
HSF1 BAG3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 23983126 19006120 20692357
BAG6 CD4 â—¼   DOWN_REGULATES ✅ - 8.0 1.0 ACSN 16286920 18055229 20819927 22437870 22863785 23414611 27192565 28900677
CDKN1A CDK6 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 14517297 17092340 9106657 18710949 24515438 20843055
SMAD2 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9618481 12200968 17516505 14762439 10506225 24052079 14583455
RELA CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18954936 22305266 23037503 18269916
SMAD4 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10878024 9618481 9865717 11786386 9307274 24052079 12429655 10962574 10415848
EZH2 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 21572997 21546904 24074410 21629038 22956625
RUNX2 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 21913213 17438369 19179305 15107836 12391164
MYC CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 41.0 1.0 Omnipath 15190211 14519204 15616584 12408868 19174556 21949397 10319992 12553001 16204065 12545156 20878079 21042278 21400515 20190815 16706751 23804320 15757889 10920185 19270520 16452181 12408820 15528212 22371483 12565816 17885207 12384701 11274368 19150257 20551174 15899785 21120446 15071503 15474507 22814619 12835716 12748190 16738884 15711923 18636159
FOXO1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17609436 23574718 23918930 24769335
HIF1A CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15071503 15190211 10559391 20043814 21362093
SMAD3 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10878024 9618481 14755691 10601254 16819512 17516505 10506225 14647420 14583455
PPARG CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 19551868 19103521 19208833 16985067 18509005 15041706 15345676 16091736
MYC CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 15528212 9618481 12545156 17550342 10454538 15155580 11283613 10920185 11283614
SMAD3 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9389648 9618481 17550342 12545156 11013220 15155580 11074002
MAP3K5 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17325029 12820963
SMAD2 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9389648 9618481 12545156 17550342 11013220 15155580 9670020 11074002 11283614
CDK6 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 25121590 20102411 15964852 22375140 15232106 16713569 16508017 19440234
AKT1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 74.0 1.0 Omnipath 11756412 11923280 16697215 20452955 27603133 20398329 18372248 15001356 15808505 10217147 19440234 20138985 12431783 10753973 17855660 19216069 28358423 20214616 11463845 9829964 17570479 17646672 16680151 11231573 15169778 12851486 31575057 25241761 23109003 21933447 10949026 16775416 23886938 26436589 16288292 11715018 16055744 18636226 15023346 9812896 12042314 17680028 24848107 16982699 11779850 10722653 20832730 18570873 20307683 34069970 17052453 15798220
MAPK8 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 12730199 15964852 17325029 19664994 12058028 11779850 17570479 20519948 16964243 18669648
SMAD4 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9389648 9618481 17550342 12545156 11013220 15155580 11074002
FOXO1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15084259 19380174 21708191 15084260 21613825 17940099 11154281
HSPA1B DNAJB1 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 Reactome 10954706 1754405 1586970 9920933 15802566 12974469 12853476
DNAJB1 HSF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 9869631 16189514 9499401
HSPA1B DNAJC7 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 Reactome 10954706 1754405 1586970 9920933 15802566 12974469 12853476
AKT1 FOXO1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 15987244 10358075 10102273 12857750
CTNNB1 FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 17254970 15905404
AKT1 FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 90.0 1.0 Omnipath 21440011 10358014 11756412 10358076 31308176 20452955 21798082 11410590 20398329 11311120 11544290 28279977 10217147 15132996 23331499 19216069 11237865 20214616 11463845 16076959 11030146 12228231 9829964 18951090 23180781 17570479 10102273 18593906 17646672 16680151 12456685 18423396 18985696 18988627 17962350 30728292 16670091 18786403 14664696 25241761 16341064 11980723 10358075 2984676 13679577 12560069 10377430 11251083 17680028 2987962 17254970 11864996 20041807
CSNK1G2 FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16511445 21233202 7641885 11980723 15121840
SGK1 FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 23331499 10358014 17640988 11410590 21531565 11980723 19965929 12560069 17684529
SMAD3 FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18391971 15084259
FOXO1 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16670091 12966085 17317207
MAP3K7 HIPK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15082531
CASP6 HIPK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19788416 16601678
HIPK2 DAXX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 19465479 14678985
HSF1 HSPA1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 21932106 24041570 21085490 19336471 20692357 11423545 18434628
MAPK3 HSF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 53.0 1.0 Omnipath 17081983 20166139 34363019 26359349 22768106 24516381 24126052 19413330 15302935 28618124 30138434 10747973 27639166 27997575 20068231 31614463 12917326 8940068 18669648 27105490 26340096 27605553 25752395 27487129 9121459 25406061 33461973 27354066 19651622 31657478 31940498 26010766 32959058 33268814 19664994 22172248 24954509 27791982 18212344 25024384
PLK1 HSF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 18794143 27354066 19934326 15661742
PRKACA HSF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 22216146 31516744 21085490
CAMK2A HSF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 23587601 26361762 25380824 24746225 22496356 28415561 15760475 11447121 25963659 33177089 15302935 26193369
MAPK8 HSF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 19651622 17081983 10747973 20166139 18767875 20068231 18669648
MYC HSPD1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 19022255 12695333 14519204 21995449 11983916 11085504
FGFR3 MAPK3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
MAPK3 SMAD2 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 10197981 16156666 27153775 29577978
MAPK3 SMAD3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 10197981 16156666 27153775 29577978
PRKCZ MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11035106 12942541 23109003 12900386 15721486
MAPK3 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 18463697 9155018 21071413 32482868 18988627 15210690
MAPK3 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 47.0 1.0 Omnipath 17081983 16156666 19413330 11027280 9620846 33676893 23331499 8226933 20068231 18988627 12193595 18491316 18691976 8388392 19651622 10197981 18775330 19115199 9604935 15212693
MAPK3 HDAC6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 24089523
MAPK3 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10551817 18519666 24099156
MAPK3 RPS6KA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 23331499 15342917 18039929 12832467 23109003 8387505 14966081 9915826 21071413 17906627 9430688 11335727 18988627 11532940 10411321
MAPK3 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 10197981 9335504
MAPK3 ARRB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 25.0 1.0 Omnipath 19651622 19153083 18767875 17322306 15456867 10347142 20068231 19413330 9388255
MAPK3 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 28115363 12801888
MAPK3 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 23331499 10197981 15241418 24080014 18775330 8226933 16156666 9604935 12193595 8388392
MAPK3 RUNX2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 27687725 19264160 29057206 25867060 19801668 25122769 21965325 25187572
MAPK3 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18596912 11733495
MAPK3 TAL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 19651622 23331499 11904294 8423803
MAPK3 NOS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17804409
PLK1 MYC â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11073952 17596790 18931676 19270156 19622404 19686080 8127874
NFKB1 MYC â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 18490439 19219071 21725609 2191300 23178297 23572150
MYC PPARG â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 10432118 11274345 11283614 11875494 16327802 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21093321 21372296 21406394 21765015 2191300 22067385 22461508 23124025 23390297 25002027
MYC HIF1A â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 10432118 11274345 11283614 11875494 16327802 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21093321 21372296 21406394 21765015 2191300 22067385 22461508 23124025 23390297 25002027
NFKB1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 12894581 18184402 7869034 17673602 12783888 11114727 17944672 9596659 12504005 19469019 21790895 19766095 17018379 8289784 18566231 1515224
RELA MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 12894581 18184402 7869034 17673602 12783888 11114727 17944672 9596659 19469019 21790895 19766095 17018379 8289784 18566231
SMAD4 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11689553 17132729
HIF1A MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 20404562 23059786 19845622 18616527 15780936 21303984
PPARG MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11973610 17462534 16405739 19075513
CTNNB1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 21533051 19778454 16510874 12095419 17360646 18852287 15576399 19561604 20300972 19662654 15579438 17724465 9727977 24447505 18679417 12907606
SMAD3 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 15930298 20516082 14993291 17132729 16205635 25238097 11689553 17114344
LEF1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19620402 18202148 17132729 19653274
MYC PTEN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23135913 19578399 12695333
MYC ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20920219 21627565 7906953 23421821 20716114
MYC EIF4E â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 18593934 15094771 8756633 12695333 24814906 14519204 22456335 16112647
MYC PARP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23277454 12695333
MYC CDK6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20682794 22395148 12835716
PLK1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18931676 19270156 25915540 23887393 19622404 19686080
CHUK MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17306568 17666529 23343194 21285352 15576399 21151179 22761862 22290435 16039586 19619488 19623618 17143292
CTNNB1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 19751508 7542250 11967263 22290435 19623618 16574648 23343194 11955436 22270359 22761862 16039586 15810077 17143292 12051714 8666229 22943793 15576399 21151179 16940750 17306568 17666529 21285352 19619488
LEF1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 19751508 7542250 11967263 22290435 19623618 23343194 11955436 22270359 22761862 16039586 15810077 17143292 12051714 8666229 22943793 15576399 21151179 16940750 17306568 17666529 21285352 19619488
MAPK8 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 19651622 10551811 17081983 18767875 20068231 91332050 1651323 1748630 16713569 11243879 18669648 15210690
MYC SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 11804592
MYC EIF4E â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18593934 16915296
MYC SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 11804592
OTUB1 UBE2N â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 22367539 21130715 24145445 21763684 35500217
PARP1 POLB â—¼   PHYSICAL_INTERACTION 72.0 1.0 ACSN 10858306 11163244 11283614 11756412 11948190 12032095 12202749 12637553 14624239 14726013 15385537 15385968 15703371 16442856 16449207 16697054 17055429 17088286 17116323 17116881 17638872 17965729 18087292 18398454 18524993 18558713 18584027 18809224 19208614 19364882 19490890 19546231 1974050 19748837 19772495 19847258 20027199 20064462 20211143 20227374 20478261 20510258 20603072 20691907 20713526 21251944 21270334 21376743 2191300 22021614 22055391 22469522 22657828 22713970 22743550 22921416 22973052 23082994 23145148 23161013 23253856 23414611 23562323 23568489 24036544 24050180 24210699 24684389 24709898 24976506 8264637 8978692
PARP1 POLB â—¼   SHARES_COMPLEX 72.0 1.0 ACSN 10858306 11163244 11283614 11756412 11948190 12032095 12202749 12637553 14624239 14726013 15385537 15385968 15703371 16442856 16449207 16697054 17055429 17088286 17116323 17116881 17638872 17965729 18087292 18398454 18524993 18558713 18584027 18809224 19208614 19364882 19490890 19546231 1974050 19748837 19772495 19847258 20027199 20064462 20211143 20227374 20478261 20510258 20603072 20691907 20713526 21251944 21270334 21376743 2191300 22021614 22055391 22469522 22657828 22713970 22743550 22921416 22973052 23082994 23145148 23161013 23253856 23414611 23562323 23568489 24036544 24050180 24210699 24684389 24709898 24976506 8264637 8978692
PARP1 SNAI1 â—¼   ENZYMATIC_REACTION ✅ 35.0 1.0 ACSN 14726013 15211575 15498778 15703371 16697054 17088286 17116881 17965729 18584027 18809224 19208614 19362533 19364882 19654615 19847258 19892829 20064462 20603072 21270334 21376743 21577210 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24089143 24095737 24210699 24684389 24976506
PARP1 SNAI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 17088286 20603072 21577210 15703371 24050180 19208614 19364882 22469522 22713970 23562323 14726013 21376743 21270334 19847258 23568489 23145148 22055391 22921416 24210699 16697054 22743550
PLK1 FADD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 25949173 20890306
PLK1 SNCA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 19004816 21849493 28067771 19889641
HIF1A PMAIP1 â—¼   ENZYMATIC_REACTION ✅ 66.0 1.0 ACSN 10102273 10428030 10428780 10435632 10804084 10823814 11557773 11559532 11744734 11756417 11884613 12402042 12676992 12743597 14672622 14684737 14699081 14762718 15024076 15059920 15199147 15240700 15312748 15369676 15379897 15545625 16110315 16126909 16127144 16517405 16517406 16585195 16782875 16888645 17143338 17418790 17533374 17785433 18054315 18056423 18158893 18718909 19211554 20028863 20427344 20535745 20855962 21051947 21765015 22006996 22841746 22850421 22988108 24006507 25043024 25103413 25732824 7493931 7500013 7508926 8089148 8702901 8955077 9486205 9525945 9707622
HIF1A PMAIP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12676992 14699081 16888645 14684737
NR3C2 SGK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16533503 17200434 12969137 24491541 14614041
SIRT6 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19408108 19135889
SMAD3 SNAI1 â—¼   PHYSICAL_INTERACTION 20.0 1.0 ACSN 11074002 11279127 11792802 12702545 12809600 15265520 16179589 16713975 17018611 17563753 18768831 19597490 21041997 21042762 21577210 21614932 22331441 22514743 8515656 9389648
SMAD4 SNAI1 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 11074002 11279127 11792802 12490555 12702545 12809600 14623871 15265520 16179589 16510505 16617148 16713975 16831886 17018611 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18768831 18832382 19208835 19412634 19597490 20731704 21041997 21042762 21199805 21317430 21577210 21614932 21883379 22006115 22331441 22406545 22514743 22945800 8515656 9389648
SNAI1 EZH2 â—¼   PHYSICAL_INTERACTION 8.0 1.0 ACSN 15465827 17018611 17563753 21234400 21577210 21685935 22514743 22796940
SMAD3 SNAI1 â—¼   SHARES_COMPLEX 20.0 1.0 ACSN 11074002 11279127 11792802 12702545 12809600 15265520 16179589 16713975 17018611 17563753 18768831 19597490 21041997 21042762 21577210 21614932 22331441 22514743 8515656 9389648
SMAD4 SNAI1 â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 11074002 11279127 11792802 12490555 12702545 12809600 14623871 15265520 16179589 16510505 16617148 16713975 16831886 17018611 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18768831 18832382 19208835 19412634 19597490 20731704 21041997 21042762 21199805 21317430 21577210 21614932 21883379 22006115 22331441 22406545 22514743 22945800 8515656 9389648
SNAI1 EZH2 â—¼   SHARES_COMPLEX 8.0 1.0 ACSN 15465827 17018611 17563753 21234400 21577210 21685935 22514743 22796940
SNAI1 PTEN â—¼   DOWN_REGULATES ✅ - 66.0 1.0 ACSN 10048576 11283614 11708773 12490555 12545156 12668723 14623871 14673164 15111329 15151915 15155580 15181457 15448698 15459715 16001073 16079281 16232121 16510505 16556862 16617148 16716598 16831886 17018611 17055429 17093497 17403902 17490644 17537911 17550342 17563753 17615296 17671186 18172008 18297062 18832382 19208835 19412634 19564415 19597490 19935649 20027199 20702634 20706219 20713526 20731704 21041997 21051859 21159887 21199805 21317430 21577210 21685935 21883379 2191300 22006115 22286765 22406545 22439866 22514743 22796940 22945800 23140366 23869868 8844971 9157999 9618481
SMAD4 SNAI1 â—¼   UP_REGULATES ✅ + 41.0 1.0 ACSN 11074002 11279127 11792802 12490555 12702545 12809600 14623871 15265520 16179589 16510505 16617148 16713975 16831886 17018611 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18768831 18832382 19208835 19412634 19597490 20731704 21041997 21042762 21199805 21317430 21577210 21614932 21883379 22006115 22331441 22406545 22514743 22945800 8515656 9389648
SMAD3 SNAI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 20731704 9389648 18832382 16831886 17563753 22406545 11074002 21317430 16617148 17671186
LATS2 SNAI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 34335956 27840647 26831822 21952048 24168186
SQSTM1 FADD â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 12702723 15340068 16252010 16498403 20531300 21981924 23069999 25002027 26587781 28574505 9184224
SQSTM1 DAXX â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 12702723 15340068 16252010 16498403 20531300 21981924 23069999 25002027 26587781 28574505 9184224
SQSTM1 RIPK1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 12702723 15340068 16252010 16498403 20531300 21981924 23069999 25002027 26587781 28574505 9184224
TBK1 SQSTM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 24818040 25040165 29147513 28655770 31810986 28871090 25505069 32966780 27846364 31444413 27404485 34996837 32835772 24886973 30223576 29930914 29973599 27005665 22921120 25723488 25972374 33084718
SQSTM1 RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 26416459 10356400 19850933
STUB1 TAL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19406989 17962192
STUB1 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 14701756 22298955 23344957 21454478 15761153 15708501
UBE2D3 HIF1A â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
UBE2D3 EPAS1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
UBE2D3 NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10835356
LATS2 YAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 36.0 1.0 Omnipath 22863277 20048001 18413746 24525530 15302935 19797269 17974916 18640976 18369314 29179447 18669648 25670202 26578655 29680477 18565851 21233212 21041410 18158288 19919647 18220336 21832154 22658639 21041411 24976283 26598551
AKT1 YAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 79.0 1.0 Omnipath 27979972 25360797 26804165 28273460 25751140 24101154 25751139 34052254 25362852 28114269 28793266 26265440 31239271 25601544 28474680 33630828 26119935 27144834 27425596 25531778 34206989 34465890 21945154 25195862 31792377 18640976 28775168 32015438 32523092 22234184 33536280 33622361 30600590 24362629 34155345 24658687 21060948 33162394 20153295 26668327 21730131 26549256 21666719 25605730 26039999 34226698 20823509 34516278 27033705 32064037 32271880 32513743 33990468 24812269 32053631 32929029 34058200 25772246 26364602 27765911 26678338 27979971 33552953 28171658 34129887 21376238 28416665 25998128 25109332 12535517 31988076 26933062 26598551 25373897
YAP1 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19914168 35044719 23431053 21685363
UBE2D1 EPAS1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
UBE2D1 HIF1A â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
CDK6 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 17208333
RIPK1 FADD â—¼   PHYSICAL_INTERACTION 90.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 1134007 11438547 11460167 11583996 11875494 12215447 12646658 12702723 12724420 12811837 1431106 14607933 14625680 14660645 14730360 14744430 15099563 15592525 15699106 15760909 16406523 16498403 16713974 16940415 17301840 17462996 17916596 18264787 18545270 18633355 18641653 19392652 19411070 19427028 19498109 19524512 19524513 19597341 19632174 19838173 20038811 20184663 20435894 20452955 20531300 21133840 21232017 21411734 21826665 22421439 22427918 22955274 23010170 23069999 23073834 23170255 23377657 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24366341 24378531 24699077 24958845 26024392 26201938 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 8910423 9184224 9217161 9488730 9759866
FADD DAXX â—¼   PHYSICAL_INTERACTION 40.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22427918 23010170 23069999 23377657 23850759 24378531 26587781 26653790 26972597 27984721 28574505 9184224 9488730 9759866
RIPK1 FADD â—¼   SHARES_COMPLEX 90.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 1134007 11438547 11460167 11583996 11875494 12215447 12646658 12702723 12724420 12811837 1431106 14607933 14625680 14660645 14730360 14744430 15099563 15592525 15699106 15760909 16406523 16498403 16713974 16940415 17301840 17462996 17916596 18264787 18545270 18633355 18641653 19392652 19411070 19427028 19498109 19524512 19524513 19597341 19632174 19838173 20038811 20184663 20435894 20452955 20531300 21133840 21232017 21411734 21826665 22421439 22427918 22955274 23010170 23069999 23073834 23170255 23377657 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24366341 24378531 24699077 24958845 26024392 26201938 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 8910423 9184224 9217161 9488730 9759866
FADD DAXX â—¼   SHARES_COMPLEX 40.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22427918 23010170 23069999 23377657 23850759 24378531 26587781 26653790 26972597 27984721 28574505 9184224 9488730 9759866
FADD DAXX â—¼   ENZYMATIC_REACTION ✅ 40.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22427918 23010170 23069999 23377657 23850759 24378531 26587781 26653790 26972597 27984721 28574505 9184224 9488730 9759866
FADD MAP3K7 â—¼   ENZYMATIC_REACTION ✅ 57.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
MAP2K7 FADD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 11034606 10640736 16061179 15001534
PRKCZ FADD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16189514 11739185
FADD RIPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 38.0 1.0 Omnipath 16585540 22864571 26733177 11002422 11854271 19524512 21458669 21525013 21052097 26865630 21741934 23972990 21620750 26186194 27560715 24098568 20203691 16227629 32296183 18485876 32024820 22890322 11464215 21737329 12887920 21183682 19524513 26972597 19373245 22848449 24577083
SMAD3 SMAD4 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
SMAD2 SMAD4 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
SMAD4 SMAD3 â—¼   PHYSICAL_INTERACTION 72.0 1.0 ACSN 10454538 10925299 10964912 11007770 11013125 11013220 11074002 11114293 11224571 11279127 11283613 11283614 11376132 11399519 11792802 11875494 12193690 12545156 12702545 12809600 14976548 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 16831886 17018611 17055429 17260466 17550342 17563753 17689680 17705132 18353785 18768831 18832382 19208835 19597490 19815509 19901969 20027199 20713526 20731704 21041997 21042762 21098712 21252118 21317430 21577210 21614932 2191300 22331441 22514743 22652804 23140366 23338822 23390297 23784029 23869868 25374926 6357187 8515656 8871614 8893010 9312026 9389648 9618481 9670020
SMAD4 SMAD2 â—¼   PHYSICAL_INTERACTION 52.0 1.0 ACSN 10454538 10925299 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11399519 11792802 11875494 12193690 12545156 12702545 12809600 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 17055429 17260466 17550342 17689680 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23390297 23784029 23869868 6357187 8515656 8871614 9312026 9389648 9618481 9670020
SMAD4 SMAD3 â—¼   PROTEIN_INTERACTION 72.0 1.0 ACSN 10454538 10925299 10964912 11007770 11013125 11013220 11074002 11114293 11224571 11279127 11283613 11283614 11376132 11399519 11792802 11875494 12193690 12545156 12702545 12809600 14976548 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 16831886 17018611 17055429 17260466 17550342 17563753 17689680 17705132 18353785 18768831 18832382 19208835 19597490 19815509 19901969 20027199 20713526 20731704 21041997 21042762 21098712 21252118 21317430 21577210 21614932 2191300 22331441 22514743 22652804 23140366 23338822 23390297 23784029 23869868 25374926 6357187 8515656 8871614 8893010 9312026 9389648 9618481 9670020
SMAD4 SMAD2 â—¼   PROTEIN_INTERACTION 52.0 1.0 ACSN 10454538 10925299 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11399519 11792802 11875494 12193690 12545156 12702545 12809600 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 17055429 17260466 17550342 17689680 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23390297 23784029 23869868 6357187 8515656 8871614 9312026 9389648 9618481 9670020
SMAD4 NOS2 â—¼   DOWN_REGULATES ✅ - 25.0 1.0 ACSN 10925299 11074002 11279127 11399519 11792802 11875494 12193690 12702545 12809600 15265520 15644117 16127449 16179589 16713975 17260466 17689680 18768831 21042762 21614932 22331441 23390297 6357187 8515656 8871614 9389648
SMAD4 SMAD3 â—¼   LOCALISATION ✅ 72.0 1.0 ACSN 10454538 10925299 10964912 11007770 11013125 11013220 11074002 11114293 11224571 11279127 11283613 11283614 11376132 11399519 11792802 11875494 12193690 12545156 12702545 12809600 14976548 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 16831886 17018611 17055429 17260466 17550342 17563753 17689680 17705132 18353785 18768831 18832382 19208835 19597490 19815509 19901969 20027199 20713526 20731704 21041997 21042762 21098712 21252118 21317430 21577210 21614932 2191300 22331441 22514743 22652804 23140366 23338822 23390297 23784029 23869868 25374926 6357187 8515656 8871614 8893010 9312026 9389648 9618481 9670020
SMAD2 SMAD4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16052471 11376804 11456453 9812998
SMAD4 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21836474 21926264 16580992 12524424
SMAD3 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 104.0 1.0 Omnipath 25609649 9843571 15084259 20211142 21532621 24584437 18729074 23788427 12419246 18923419 9892009 19768112 10531362 15231748 9679060 12167862 21988832 12150994 23331499 12543979 18568018 21071413 19135894 15467747 25502805 9732876 11927552 16189514 12917407 25514493 15350224 10995777 18988627 10092624 12732634 25910212 10878024 9111321 20564330 27107012 9311995 12957874 20142324 11114293 32296183 15588252 15761153 24157709 26555259 29892012 17469184 22442258 16714330 21597466 15922743 22045334 17591701 24382352 22310290 19139564 19917253 29997244 31515488 28115363 10942775 21297662 17283070 12794086
SMAD5 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 20957627 23331499 14534577 16516194 16189514 10531362 15231748
SMAD2 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 110.0 1.0 Omnipath 15613484 17145710 25609649 15817471 20211142 21532621 24584437 18729074 23788427 12419246 16916642 9288972 9892009 21454478 17510063 10531362 15231748 11027280 12167862 21988832 9389648 23331499 12543979 18568018 21071413 19135894 18511908 15467747 12808092 11927552 25514493 15350224 18988627 12732634 10878024 9111321 9311995 9346908 10199400 11264182 12957874 11114293 15761153 11274206 12621041 17272273 24157709 26555259 12374795 22442258 10781087 15922743 11102446 17591701 18783722 16751102 19139564 19917253 9346966 21297662 17283070 12794086
SMAD1 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 34.0 1.0 Omnipath 17183365 9436979 24412244 11779505 31467278 21454478 10531362 15231748 12167862 23331499 21071413 11700304 12874272 16189514 18988627 20957627 9111321 15761153 32296183 26555259 14701756 14534577
SMAD4 LEF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 10890911 21071413 18988627
MAP3K7 CAMK2A â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 12556497 10380924 10391246 10488343 12482967
CHUK MAP3K7 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 20300203 9744859 17047224 11460167 17496917 14514672
RIPK1 MAP3K7 â—¼   ENZYMATIC_REACTION ✅ 57.0 1.0 ACSN 10925299 11003656 11112697 11274345 11280761 11438547 11460167 11875494 12646658 12811837 1431106 14607933 14625680 14660645 14730360 15099563 15592525 15699106 16713974 17301840 17462996 17916596 18264787 18633355 18641653 19392652 19411070 19524513 19632174 20038811 20184663 20435894 20531300 21133840 21232017 21411734 21826665 22955274 23010170 23170255 23430059 23508573 23510023 23567181 23769623 23850759 24092389 24378531 24699077 24958845 26201938 26587781 26653790 26972597 28574505 8910423 9488730
MAP3K7 FOXP3 â—¼   ENZYMATIC_REACTION ✅ 26.0 1.0 ACSN 10391247 11280761 11460167 12620219 14633987 14660645 15082531 15125833 15282297 16200688 16603398 16799562 17301840 17363905 18264787 18641653 19161412 20060931 20164171 21041997 21133840 21232017 22941947 24403530 24699077 24958845
IRAK1 MAP3K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12242293 17197697
MAP3K7 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 17145710 14960582 16893890 15836773 33895773 12547194 25241761 24911653 2547194 9742107 18949366 11274345 20200282 20194509 10094049 18855897 10187861
MAP3K7 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15692051 17947236 11865055 17965022 17186025
MAP3K7 MAP2K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 17110930 17709393 25241761 9890973
RIPK1 MAP3K5 â—¼   PHYSICAL_INTERACTION 22.0 1.0 ACSN 11274345 12556535 12655147 12738796 14730360 15592525 17462996 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23850759 24378531 26587781 26653790 28574505 28765050
RIPK1 DAXX â—¼   PHYSICAL_INTERACTION 40.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22427918 23010170 23069999 23377657 23850759 24378531 26587781 26653790 26972597 27984721 28574505 9184224 9488730 9759866
RIPK1 DAXX â—¼   SHARES_COMPLEX 40.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22427918 23010170 23069999 23377657 23850759 24378531 26587781 26653790 26972597 27984721 28574505 9184224 9488730 9759866
RIPK1 MAP3K5 â—¼   SHARES_COMPLEX 22.0 1.0 ACSN 11274345 12556535 12655147 12738796 14730360 15592525 17462996 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23850759 24378531 26587781 26653790 28574505 28765050
RIPK1 DAXX â—¼   ENZYMATIC_REACTION ✅ 40.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22427918 23010170 23069999 23377657 23850759 24378531 26587781 26653790 26972597 27984721 28574505 9184224 9488730 9759866
RIPK1 MAP2K7 â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 11274345 12556535 12655147 12738796 14730360 15592525 17462996 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23850759 24378531 26587781 26653790 28574505 28765050
RIPK1 MAP2K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12655147 21614932 12738796 11274345 18855897
SMAD3 SMAD2 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10454538 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23869868 8515656 9312026 9389648 9618481 9670020 9865696
SMAD3 SMAD2 â—¼   PROTEIN_INTERACTION 41.0 1.0 ACSN 10454538 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23869868 8515656 9312026 9389648 9618481 9670020 9865696
SMAD2 NOS2 â—¼   DOWN_REGULATES ✅ - 24.0 1.0 ACSN 10925299 11074002 11279127 11399519 11792802 11875494 12193690 12702545 12809600 15265520 15644117 16127449 16179589 16713975 17260466 17689680 21042762 21614932 22331441 23390297 6357187 8871614 9389648 9670020
CAMK2A SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 11027280
SMAD2 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 21988832 26186194 12543979 9111321 15084259 9311995 25878769 18729074 12700238
SMAD2 LEF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 10890911 21071413 18988627
SMAD3 NOS2 â—¼   DOWN_REGULATES ✅ - 25.0 1.0 ACSN 10925299 11074002 11279127 11399519 11792802 11875494 12193690 12702545 12809600 15265520 15644117 16127449 16179589 16713975 17260466 17689680 18768831 21042762 21614932 22331441 23390297 6357187 8515656 8871614 9389648
SMAD3 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21836474 21926264 12457461 12524424
SMAD3 FOXP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 26365427 22908322 25065622 18157133 23243069 20937549 19701891
AKT1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 25241761 15104092 16362038 21071413 18988627 26297431 15048128
MAPK8 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10601313 25714018
CSNK1G2 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 18794808
SMAD3 LEF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 10890911 21071413 18988627
SMAD3 RUNX2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 21986102 10962029 15084595 11331591 10531362
EIF4E HIF1A â—¼   UP_REGULATES ✅ + 16.0 1.0 ACSN 10403805 11566883 12080085 12829734 13130303 15451019 15563472 16887934 1823643 7539918 8943284 9155017 9159130 9278421 9746763 9878069
PTEN AKT1 â—¼   DOWN_REGULATES ✅ - 22.0 1.0 ACSN 10753747 11747822 12040186 15721744 16288286 16982858 17218262 17409395 19440036 19847259 19945467 20609352 21084277 22179046 22465479 23732914 24030100 24254977 25364523 26597054 27328425 27572739
PPARG PTEN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18065496 16775433 16425225 23867870 20198337 11378386
SRC PTEN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 24830552 22891331 12869565 21532586
AKT1 PTEN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 19903340 15987703 10790335 20596030 10592173 20605778 10866658 12077256 11035045 16107342 12297295
PTEN PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 9616126 15717329 10427092 23109003 10400703 10592173 9927060 23397142 11857088
DAXX HSPB1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 ACSN 11003656 11274345 16406523 20452955
DAXX HSPB1 â—¼   PROTEIN_INTERACTION 4.0 1.0 ACSN 11003656 11274345 16406523 20452955
HSPB1 DAXX â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 25241761 11003656 11193028 15911090
DAXX MAP3K5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 17145710 23331499 9743501 15258908 25241761 21071413 19789334 15983381 11003656 11495919 27488634
CHUK RELA â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 9315679 9914500 9721103 10593898 9135156
CHUK NFKB1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 9315679 9914500 9721103 10593898 9135156
AKT1 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 15710601 12048203 25241761 19442713 11278366 10485711 15800029 19609947 17570479 17660512 18515365 19088076 10485710
SRC CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 17145710 12707358
CHUK RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 49.0 1.0 Omnipath 17145710 15611276 22110409 19609947 10521409 20863851 20051109 20363318 12767944 26999213 12842894 21903422 19110719 15858576 16382138 22155370 23894194 16046471 15128824 21569639 16846590 8246997 15485852 25341660 15494311 11983155 15980040 15489227 15849198 14636585 23343355
CHUK NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 39.0 1.0 Omnipath 12482991 19442713 14743216 15494311 11976329 15489227 16382138 16713569 10022904 10469655 27554194 11158290 11297557
NFKB1 RELA â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
PRKACA RELA â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17462920 12628924 19197368 19122653 18385332
PRKACG RELA â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17462920 12628924 19197368 19122653 18385332
RELA NOS2 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 14668329 15079071 15536066 17145890 17404308 17550372 19171876 20138012 23430059 8383323 8580069 9743347
RELA AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20186924 18031796 20649564
RELA NFKB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 16778171 20427719 23362108 16513645 1740105 20596645 16513841 19469019 8454856 21420936 16135789 9417120
RELA NOS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 23085209 17720813 12057007 15350552 17068060 20600530 18596035 24360823 11036073 10085153 16318585 24014650 17035338 16169848 9754583 14978160 16283237 19766095 15170030 9712833 18057724 9685183 17081374 17041221
RELA F3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 15242552 11057875 12746898 9867853 18226221 19167713 7615158 7929355 9081693 11157486
RELA HIF1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18498249 17898080 23185316
RELA CYP3A4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19002106 16608838
NFKB1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 88.0 1.0 Omnipath 17145710 16209943 25609649 8428580 12947093 16970925 17072323 2050119 15657065 21270162 11976329 16793322 21544861 22261743 8657102 9824778 11880271 9450761 17962807 21988832 25355951 9722548 18215660 14743216 15799966 10799898 16105840 15218526 8798655 14690596 22139845 22808155 11571291 17072327 16740634 10498867 8255759 8246997 15214841 16846590 15371334 16285893 17072322 17855547 18321863 16493424 7479976 15145317 17561400 20110362 9426183 23687337 12414801 11970949 20154269 20237821 24175631 24634218 34100597 14645533 17982102 21763497 16204234 9437432 20547752 15818410 7628694
PRKCZ RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 11684013 21515635 15210811 21131967 12881425 34230209 16189514 17183360 33864076 27466442
PRKACA RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 11931769 15833743 9150141 17959673 9660950 16135789 12628924
TBK1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 12842894 17562815 15128824 15485852 10521409 15489227 15849198 14560022 19958770 12767944
PPARG NOS2 â—¼   DOWN_REGULATES ✅ - 11.0 1.0 ACSN 11399519 11875494 15644117 16127449 17260466 17681149 17689680 21234400 23390297 6357187 8871614
PPARG SOD1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15590897 16951334 19535992 17337254
PPARG NOS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15950726 11595817 19997048 10848596
PPARG ABCG2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16785230 18086804 18288266
PPARG RUNX2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12878983 18715135 20589837 12704187
PPARG CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 12021175 15190077 20303941 14764597 19075513
SRC PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 30323259 10322133 26385316
MAPK8 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 9030579
CTNNB1 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 25721714 16847334 25168821 19495794
MAP3K5 MAP2K7 â—¼   ENZYMATIC_REACTION ✅ 14.0 1.0 ACSN 11274345 12556535 12655147 12738796 15592525 17462996 18641653 18855897 19392652 21133840 21232017 21614932 23850759 24378531
AKT1 MAP3K5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 16532036 14500571 11154276 30677014 17184578
MAP3K5 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 50.0 1.0 Omnipath 17634293 20348951 15247305 21785467 12194869 12221076 18818208 18029441 19667122 21726807 16760468 21212517 19749799 26147002 25310587 33573023 26375285 16648474 15944157 7839144 12456653 25915038 26853469 21856198 31575661 10521505 25702873 19029119 20156337 16928747 15020250 20452983 15242986 18570871 16845370 20871632 21040800 27203743 19783996 21931634 23608534 21697492 25619840 26964622 12758252 16632641 28881794 17210579 34048499 20921231
MAP3K5 MAP2K7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 12556535 19392652 18855897 17462996 19920149 18641653 23331499 23850759 21071413 12655147 21614932 21133840 12738796 21232017 24378531 15592525 11959862 17110930 26192618 11274345
UBE2D2 HIF1A â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
NFKB1 HIF1A â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 17272744 18393939 21725609 23178297 23572150
HIF1A FOXP3 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 10804084 16110315 16127144 17533374 20427344 20535745 20855962 21051947 21765015 22006996 22850421 22988108 24006507 25043024 25103413 25732824
HIF1A PDK3 â—¼   ENZYMATIC_REACTION ✅ 66.0 1.0 ACSN 10102273 10428030 10428780 10435632 10804084 10823814 11557773 11559532 11744734 11756417 11884613 12402042 12676992 12743597 14672622 14684737 14699081 14762718 15024076 15059920 15199147 15240700 15312748 15369676 15379897 15545625 16110315 16126909 16127144 16517405 16517406 16585195 16782875 16888645 17143338 17418790 17533374 17785433 18054315 18056423 18158893 18718909 19211554 20028863 20427344 20535745 20855962 21051947 21765015 22006996 22841746 22850421 22988108 24006507 25043024 25103413 25732824 7493931 7500013 7508926 8089148 8702901 8955077 9486205 9525945 9707622
HIF1A NOS2 â—¼   ENZYMATIC_REACTION ✅ 66.0 1.0 ACSN 10102273 10428030 10428780 10435632 10804084 10823814 11557773 11559532 11744734 11756417 11884613 12402042 12676992 12743597 14672622 14684737 14699081 14762718 15024076 15059920 15199147 15240700 15312748 15369676 15379897 15545625 16110315 16126909 16127144 16517405 16517406 16585195 16782875 16888645 17143338 17418790 17533374 17785433 18054315 18056423 18158893 18718909 19211554 20028863 20427344 20535745 20855962 21051947 21765015 22006996 22841746 22850421 22988108 24006507 25043024 25103413 25732824 7493931 7500013 7508926 8089148 8702901 8955077 9486205 9525945 9707622
HIF1A EPAS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20513003 18174278 16924414 19030186
HIF1A AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19144925 17220299 17488804 14726529 15277220
HIF1A NOS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 25156364 9486205 16306444 20079239 16325051 11325839 10679484 12154035 9115299 18339887
SRC PTK2 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 11476890 12531888 16919435 17496910 17517963 20027185 25572304 26552706 27216177 8892616
ERBB2 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16769082 19617202 11940572 12753909 21075308 7542762
ESR2 SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11013076 12095943 12630920 11032808
PRKCZ SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 17496910 11940581 21386996 10527887 11447289 19615955 16488589 6321473 8321321 12845332 11313945 16189514 12040186 19568798 15567848 14585353
PRKACA SRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 19651622 17081983 20166139 2474754 18088087 15546918 19664994 11804588
SRC ARRB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 17456469 17456551 16432186
SRC MYLK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 12408982 20861316 11113114 10362724
SRC PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 216.0 1.0 Omnipath 27351421 23242524 16254240 12370821 21940449 26142360 17525734 10593973 14604860 17389395 19171305 22402981 19339212 22353809 9748249 8941336 17570479 12464388 25226367 15611085 15817476 25241761 26393679 27978555 26833789 11927607 17828307 25913180 26866924 15247219 10085298 12387730 19055942 9507031 21454698 10973994 32814053 21057587 27931517 27438371 18793427 19695571 15735019 18560762 10592173 25319025 24389213 21852560 26689988 14984767 7505391 19568240 20103658 20822514 25868388 23275294 28423510 23764511 19625610 15561106 17192257 19138410 19369195 17088251 12753909 28701735 29190494 17016520 15598735 18814847 11821402 11418135 15728464 16291744 25067788 11602246 16713569 22287273 9032297 7997267 12960434 11369622 20616959 26079101 19534553 10931187 22710722 20068231 25866790 21347260 9822703 28202937 16153436 11980671 21855630 19826415 18464795 7529876 20621036 9330873 21473875 9425168 28956212 12615911 15951569 25814554 12876384 17438336 15212693 16966330 20705914 20847951 23729178 20407018 12558988 25127991 25918719 12590707 16360410 8054685 18814027 11696015 22800863 17117420 12495636 11278488 9864370 21776383 18083107 22814579 22194915 20515733 11119718 9148935 10428489 15743500 20655298 23065768 28213315 26923073 24015220 17289681 12110680 22006118 24164353 23109003 18935208 10753828 18233957 8816475 25118939 19664994 25530216 16760434 9330875 21266176 21034468
SRC PTK2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 60.0 1.0 Omnipath 9560226 20028775 19919693 15585656 12495636 16713569 31979355 18083107 15105428 15778498 10593973 17389395 25349423 19534553 11149930 12486027 10329689 22581436 19380485 15166227 12526812 12522270 23109003 14963038 8849729 20001213 9556630 18935208 12345678 12231407 17192257 7529876 15695828 15070849 20381867 14739300 19369195 11274221 26866924 10777553 10521452 20521079
SRC NOS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 20015194 19875457 16116474
SRC CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 46.0 1.0 Omnipath 22605996 16492141 27177845 23824743 25423132 25850673 24816560 27203386 11836526 22515442 26918136 10593980 15782139 9592087 22056988 12571228 17087658 20840866 23640056 21195420 25164010 26453937 9278444 16831887 23476652 12123611 11279024 14517306 21903109 22200182 20026641 22264731 25041845 12408824 22247700
SRC SNCA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15212693 12893833 11162638 11744621 28671665 24860424 11078745 12096713
SRC AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 11445557 25241761 23242524 18283331 12600984
PRKCZ AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 11585925 15884057 14560023 16189514 11748077 18353613 11723139 10085094
TBK1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21329883 21464307 21106850
AKT1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 20858269 23331499 20028971 11882383 21303971 17680028 20214616 22094462 17287208 17374729 20398329 21506126 21402455 12040186 19623618 12063252 18218901
AKT1 HSPB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 12740362 11042204 19593530 22983196 17510053 23397142
AKT1 EZH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 22391560 24526064 29864144 34230470 16224021 26517694
AKT1 IRAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 11976320
AKT1 PRKACA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 20016067 23331499 17680028 20214616 17688959 20398329 16537363 17052453 19575820
AKT1 TAL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 19406989 15930267
AKT1 ATXN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 15757972 15824120 17540008 34302818 24903464 29212253 33709453 12741986 17570479 21722762 29758256 23719381 20037628 23213356 12757707 24858692 20477910
PRKACA NFKB1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17462920 12628924 19197368 19122653 18385332
NFKB1 SOD1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 15317858 21725609 23178297 23572150
NFKB1 PRKACG â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17462920 12628924 19197368 19122653 18385332
NFKB1 NOS2 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 21725609 23178297 23572150 7500013 7508926 9486205
NFKB1 F3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15242552 20303465 11057875 12746898 9867853 19167713 11157486
NFKB1 NOS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17250678 17081374 23811396
NFKB1 NOS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 10085153 11438703 17720813 16318585 9754583 16283237 18057724 9685183 17081374 12595462 15350552 19766095 23646894 24360823 11036073 15170030 22949549
PRKACA NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 19531803 12947093 17959673 15642694 15197457
NFKB1 NOS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9486205 7500013 19383900 7508926
PRKCZ MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10962008 8702918 18667433 17646398
PTK2B PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 9182576 16254240 15247219 16760434 7529876 12960434
ACVR1 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 19651622 9748228 23331499 9335504 10085121 10652350 9136927 10583507 16189514 11792802 18988627
INSR PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 9507031 17389395 19664994 20068231 17570479 17016520 7529876 16153436
ERBB2 PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 17496910 19617202 25241761 10545505 7657702 27638858 19339212 27939360 15743500 20201928 12753909 16919435 16713569 7529872 12600989 11807823
PRKACA CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 33914026 16199882 22173096 21303971 33815677 22094462 17287208 26068882 26884171 33605402 21506126 24117889 12297048 21822311 16476742
PRKACA KCNH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 10837251 19651622 18791070 10488078 11953308
PRKACA NOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 12630910 10400690 1375933 7532810 10874031
PRKACA TAL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 22310283
PRKACA ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18799465 9855018
PRKACG CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22094462 21506126 21303971 27892464
CTNNB1 LEF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17785445 15473860 11326276 17335794 15728254
ERBB2 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 17496910 7702605 7999105 22558232 14517306 11245482 11950845 12040186 19568798 23576562 14585353 23640056
CTNNB1 LEF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 50.0 1.0 Omnipath 16510874 23151663 11751639 15735151 17143293 16204248 23331499 12556497 21071413 14638683 15768032 18296023 12748295 21743491 11835406 16510875 18077326 8757136 9065403 20123964 15728254 17517646 21078818 15684397 8892228 10890911 15525529 12077367 9419974
DDX58 TBK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 16177806 17020950 15210742 15210743 23950712 16306936 16127453 17468758 16281057 12702806 17327220 16858409 21419663
CAMK2A NOS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 12630910 10400690 1375933 10874031
ARRB2 MAPK10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19782076 11090355 18408005 11356842
ARRB1 MAPK10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 19782076 11356842 19879840
MAP2K7 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 65.0 1.0 Omnipath 12821118 10713157 11489946 17145710 9362518 13130464 18855897 19690332 95141073 24975362 23331499 7839144 21071413 18362184 11062067 21614932 15911620 12738796 18436711 11389443 10506143 11242024 11847100 18669648 16153436 15725726 25241761 18691976 14523011 25284480 16076903 17192257 11390361 15755722 16533805 19369195 9312068 9207092 9733513 12758252 12624093 15212693 11274345
HSPA5 ERN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 18624755 26551274 31226023 12637535
ESR2 NOS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16361351 11799247 18753331 11583108
UBE2D2 EPAS1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10878807 9891082 12101228 10535940 12538644 11454738 22286099 10973499
ACVR1 SMAD5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9748228 23331499 10652350 10583507 16189514 11792802 10504300
MAP2K7 MAPK10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 11489946 9362518 18855897 18083107 10715136 23331499 9890973 11062067 21614932 15911620 12738796 11389443 11242024 12624093 11847100 18691976 16076903 14523011 15212693 11274345