Protein list:

Seperate proteins by space | Example

Select nodes using shift click or drag to add to this list
Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
Graph tools:

Note this may take some time with > 30 proteins
Filter Graph:

0.5
Layout:
  🔂

Click a node or edge for more data...
Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
GRB2 ACTR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
HIF1A BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12205045 20668552
NOTCH1 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9881968 16990763
HSP90AA1 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18266962
BCL2 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15210690
CTCF BCL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20733034
BCL6 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22422878 19487462
TP53 BCL6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16249378
BCL6 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15577913
CASP8 CASP3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18669646 0712034105
AKT3 CASP3 â—¼   CLEAVAGE ✅ 2.0 0.8 intact 17544405 5219985
CASP3 AKT1 â—¼   CLEAVAGE ✅ 2.0 0.8 intact 17544405 5219985
CASP3 CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17899380
CASP3 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9500443
CASP3 TP63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17581882
CASP3 TGM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16189514 10556977
CASP3 EIF4EBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10672017
CHRNA4 CBX1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CBX3 ADNP â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 36950384
MYC CBX5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
E2F1 CBX5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18319725 12909625
E2F1 CDC25A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15210709 18319725
AKT1 CDKN1B â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12244303 11231573
JAG1 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16495313
MYC CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 24704206 26701207
DYNC1H1 DYNLL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18535146 10491388
TP53 DYNC1H1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9781666 9627114
E2F1 CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 14706452 18794899
E2F1 KDR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20516113
HDAC1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17980157 18319725
E2F1 BIRC5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15271987 18319725
HNRNPC GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
SMARCD1 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
JAK2 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9209406 8400282
KDR GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219079 16966330
AFF2 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
GRB2 CYTH2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
GRB2 FLNB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 LMNA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 EIF4A3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 DNM2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15834155 5217666
GRB2 ANXA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 ARPC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 TPX2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
GRB2 FLNA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
HSP90AA1 HSF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11583998 9222609
HSF1 FOS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9341107 11026560
HSF1 HDAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19793920
HSF1 HSP90B1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9869631
CTNNB1 HSP90AA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CYTH1 HSP90AA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
HSP90AA1 CHUK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSP90AA1 IKBKE â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSP90AA1 HIF1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18538669 6550889
HSP90AA1 AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12799359 11988487
HIF1A HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14726529 20068160
KAT5 LMNA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
KAT5 CDC42 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
NPM1 KIF22 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
TARDBP MYC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
MYC ARF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219602 17289033
NOTCH1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10644343 16847353
MYC RAN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23468463 11085504
ESR1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 3677090
AKT1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17942906 9804616
RB1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 7838535
MYC KPNA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 35044719 17093053
NPM1 HDAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219698 17318229
RAN NUPR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16478804 0508955103
TP53 PML â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216620 12915590
RECQL KPNA4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 9168958 6549592
SMARCD1 TARDBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TP53 STK11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17108107 21317932
TP53 STK11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23995788 21317932
PARD3 TP53 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22653443 8415349
FOS TP53 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11350971 10984493
TP53 GSTM4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
TP53 CDC42 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
TP53 CSNK2A1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12393879 11239457
TP53 HNRNPC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18296503 21317560
TP53 MTA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23552838 22286760
DAXX TP53 â—¼   COLOCALIZATION 2.0 0.8 intact 14557665 5216762
TP53 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10766163 16713569
TP53 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
TP53 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
TP63 NOTCH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20442293 20950370
CASP8 TP63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17581882
LRRK2 FAM90A1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29513927 201700444
CTNNB1 RAN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RELA RAN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
EEF1A2 CHUK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
NCBP3 NCBP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22365833 8293266
DCTN3 ACTR10 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15473859 15738427
KDR CDC42 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12810700 12215529
AKT1 FLNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15461588 17570479
NFE2L2 IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 21127061 27211851
ARRB2 NOTCH1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22162134 16284625
HIF1A NOTCH1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18427106 0802047105
NOTCH1 HIF1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18427106 0802047105
NOTCH1 ARRB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22162134 16284625
KLF5 NOTCH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21868761
HRAS KLC3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RELA HDAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 11931769 5215238
HDAC1 CTNNB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19166851 6823802
HDAC1 NUP50 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
RELA HDAC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23027620
MTA1 HDAC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23791785 16511565
RB1 HDAC1 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
ESR2 NCOR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8816459 22622808
TARDBP BIRC5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
NFE2L2 CUL3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21793854 20452971
GLE1 DAXX â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CASP8 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11002417
ESR1 NFE2L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 24641954 20623181
RELA NCOR2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17876798
CSNK2A1 RELA â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5212888 10938077
FOS RELA â—¼   PROXIMITY 2.0 0.8 intact 18172215 0705181105
RELA FOS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16189514 10488148
RAC1 KLC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10913441 11689693
ESR1 RAC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21118977 11060289
HIF1A RAC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19132225 20001745
AHNAK LRRK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
LRRK2 NCBP3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29513927 201700444
LRRK2 KLC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29513927 201700444
VHL HIF1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218395 16511565
HIF1A NKX2-5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21055290 18303027
CSNK2A1 HIF1A â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 17382325 5219810
HIF1A MTA1 â—¼   COLOCALIZATION 2.0 0.8 intact 5218395 16511565
CDC42 KLC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10913441 11689693
CDC42 PARD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16189514 10934474
FGF2 FGF6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18552176 18757403
ALYREF AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18562279 0802533105
CYTH1 AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ESR2 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16549430 17261755
RB1 FOS â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 1909121 7680889
CTNNB1 VHL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16983094 0606850103
NXF1 NUP153 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10668806 5212227
DCTN1 DCTN5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15473859 15738427
AHNAK2 ACTR1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
DCTN3 ACTR1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15473859 15738427
CTNNB1 PARD3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17057644 5219258
ESR1 CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16628468
CTNNB1 FGF18 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14559787 17158875
CTNNB1 FGF20 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15592430
TARDBP HNRNPC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
AIP ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21984905
WT1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18708366 16087727
ESR1 AICDA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23181348 19139166
ESR1 HSP90B1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16511840 23038705
ESR1 WT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18708366 16087727
ADRB2 ARRB2 â—¼   COLOCALIZATION 2.0 0.8 intact 23208550 8428323
ARRB1 ADRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16407241 11171997
ADRB2 NCOR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
KLC2 FYCO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 25855459
LMNA NUP153 â—¼   COLOCALIZATION 2.0 0.8 intact 20561986 7893748
ANXA2 AHNAK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
DCTN3 DCTN5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15473859 15738427
RB1 LMNA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29997244 20178071
RYBP LMNA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TGM2 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16189514 9315663
RB1 CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15735701 11420704
RYBP TARDBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CTCF WT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24534946
CTCF NCBP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22951020
CTCF FGF17 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22951020
CSE1L KPNA4 â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
ALYREF NCBP1 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
ACTR1A DCTN3 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
NCOR2 ESR2 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 29509190 14715875 12904255
CBX1 CBX3 â—¼   PHYSICAL_INTERACTION 810.0 0.81 STRING 36370105
H3F3A SMARCD1 â—¼   PHYSICAL_INTERACTION 813.0 0.81 STRING 36370105
DCTN5 DYNC1H1 â—¼   PHYSICAL_INTERACTION 818.0 0.81 STRING 36370105
MYC CBX1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 30415952 29467282
MYC CBX3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 30415952 29467282
LRRK2 CBX3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31046837 23075850
DAXX CBX3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 24981860
CBX3 BCOR â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 24981860
DAXX CBX5 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 24981860 26496610
ESR1 EP400 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21182205 31527615
RAC1 GRB2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 31980649
MYC NXF1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 30415952 29467282
MYC MRGBP â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21150319 35140242
MYC FLNA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21150319 29467282
MYC DCTN1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17353931 29467282
MYC NCOR2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21150319 29467282
MYC ANXA2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21150319 30081903
CASC3 ESR2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 29509190 25640309
ESR2 RAN â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 29509190 21951318
ADRB2 RAN â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 23798571 24561123
LRRK2 ARPC2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31046837 20876399
LMNA FLNA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22412018 16248985
HDAC1 ADNP â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 23752268 26496610
LRRK2 GNAI2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31046837 20876399
AKT3 AKT1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
FOS ESR1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17317669 25303530
ESR1 BCOR â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 26487511 31527615
ARRB2 FLNB â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
ACTR3C ARPC1B â—¼   PHYSICAL_INTERACTION 820.0 0.82 STRING 36370105
DAXX H3F3A â—¼   PHYSICAL_INTERACTION 821.0 0.82 STRING 36370105
HSP90AA1 STK11 â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
MRGBP EP400 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 15647280 33961781 29028833 12963728
MYC LMNA â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 21150319 17314511 29467282
NUPR1 RAN â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 19650074 16478804 32780723
NXF1 CASC3 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 22658674 33961781
NCOR1 ESR2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 29509190 12904255
DAXX ADNP â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 33961781 26496610 24981860
GSTM2 GSTM4 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
IER2 GLE1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
CBX3 H3F3A â—¼   PHYSICAL_INTERACTION 831.0 0.83 STRING 36370105
CBX5 H3F3A â—¼   PHYSICAL_INTERACTION 831.0 0.83 STRING 36370105
AIP HSP90AA1 â—¼   PHYSICAL_INTERACTION 834.0 0.83 STRING 36370105
ACTR10 DCTN3 â—¼   PHYSICAL_INTERACTION 834.0 0.83 STRING 36370105
ESR1 TP53 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
CSNK2A1 HDAC1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
CASP8 CUL3 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
ESR1 MTA1 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
KAT5 MYC â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
MYC HIF1A â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 28628118 15071503 28205554
PML FOS â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 9671405 16189514
AKT1 STK11 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 28628118 24412244 28205554
RAN NXF1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 10228171 12384575
FLNA ARRB1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 16611986 17620599
BCOR HDAC1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 16713569 23658227 10898795
AKT1 CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 0.84 0.84 Signor 18423396
IPO5 KPNB1 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
CBX1 H3F3A â—¼   PHYSICAL_INTERACTION 844.0 0.84 STRING 36370105
CSNK2A1 PML â—¼   PHYSICAL_INTERACTION 844.0 0.84 STRING 36370105
DAXX HDAC1 â—¼   PHYSICAL_INTERACTION 845.0 0.84 STRING 36370105
ACTR10 DYNC1H1 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
MTA1 TP53 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
DCTN2 DYNLRB1 â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
MTA1 CUL4B â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 34026424 26028330
CUL4B HDAC1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 34026424 25189618
GRB2 FLNA â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 17474147 12577067 21706016
DAXX HSF1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 20620219 15016915
NUP153 RAN â—¼   PHYSICAL_INTERACTION 849.0 0.85 STRING 36370105
ARF6 ARRB2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 11533043 16189514 11867621
ESR1 FLNA â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 21182205 19805454 25604459
NCOR2 NCOR1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 16033423 10944117 11013263
LRRK2 CDC42 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 21048939 21454543
LMNA NUP50 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 34079125 22412018 24927568 29568061
ARF6 CYTH2 â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
CHUK RELA â—¼   PHOSPHORYLATION ✅ + 0.85 0.85 Signor 10521409
CASC3 EIF4A3 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HuRI 32296183
CASP8 BCL2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16183855 11406564
RAN IPO9 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 28514442 26344197
FOXK2 NCOR1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 25609649 27773593
NCOR1 KLF5 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 18500350 35140242
CUL3 NUP50 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 21145461 26344197
RAC1 LRRK2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 31046837 21454543
NCOR2 ESR1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 9702189 14715875 20392877 12738788 9171229 23403292
FOXK2 NCOR2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 25609649 27773593
NCOR2 KLF5 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 18500350 35140242
TP53 WT1 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
NCOR1 BCL6 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 15454082 16713569 9824158 11865059 10898795 16147992
CASP8 CASP3 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 15254227 11832478 18669646 11437602 8962078
CBX1 ADNP â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 24981860 21888893 27705803 20850016
RYBP CBX3 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 34316702 27705803 22325352 33961781 24981860
CBX5 ADNP â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 27705803 24981860 21888893 20562864
MRGBP KAT5 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 15647280 18218781 27153538 17573780 16230350 33961781 26186194 12963728
MYC ADNP â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 21150319 30415952 29467282
MYC IPO9 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 17353931 17314511 29467282
FOXK2 HDAC1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 27773593 24748658
HDAC1 VHL â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 22286234 11641274
NCOR2 FOS â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 10777532 20195357
NXF1 GLE1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 29395067 33961781
DCTN1 DCTN5 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 33961781 26638075
ESR1 FOXK2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 31527615 25740706
GSTM2 GSTM5 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 32296183 33961781 26186194
GSTM5 GSTM4 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 32296183 33961781 26186194
GSTA2 GSTA5 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 32296183 33961781 26186194
CBX3 CBX5 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
HIF1A TP53 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
GSTM4 GSTM5 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
KAT5 TP53 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
CSNK2A1 TP53 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
GSTM2 GSTM5 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
AKT1 CHUK â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
GSTM2 GSTM4 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
ESR1 ESR2 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
NPM1 TP53 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
ESR1 HDAC1 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
AKT1 CDKN1B â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
FLNA FLNB â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
CHUK RELA â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
E2F1 HDAC1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10734134 9468140 17980157 26468294 9468139
DCTN1 GRB2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 8955163 16189514
NCOR2 PML â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 11585900 11430826
FAM50B KPNA4 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HuRI 32296183
FLNA ARRB2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 17984062 16611986 17620599
CASP8 CUL3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 19427028 23142077 25551360 28574503
CDC42 RAC1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 31871319 9427749
KLC3 KLC4 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 33961781 26496610
KLC3 KLC2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 33961781 26496610
MTA1 ZNF423 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
CTNNB1 HDAC1 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
TP53 TP63 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
CSE1L KPNB1 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
PML TP53 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
CYTH2 ARF6 â—¼   GTPASE_REACTION ✅ + 0.88 0.88 Signor 14565977
BCL2 TP53 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
FAM50B ZRANB1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HuRI 32296183
NUP107 NXF1 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
BCOR BCL6 â—¼   PHYSICAL_INTERACTION ✅ + 0.88 0.88 Signor 10898795
BCL6 BCOR â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
ESR1 HSP90AA1 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
BCOR RYBP â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
HDAC1 BCL6 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 15454082 9627120 9753732 16147992 10611298
BIRC5 CASP3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16189514 11170436 9850056
CBX3 ADNP â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 20850016 29795351 27705803 33961781 21888893 24981860 32533114 34079125
ANXA2 GRB2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16189514 31980649 12577067 7510700 9565634 19380743
KAT5 MYC â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 12776177 15572685 18003922 35140242 30415952 20946988
MYC PML â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17146439 15735755 21150319 32592588 30415952
ARF6 ARRB1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11533043 16189514 11867621
HDAC1 NCOR2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11739383 16481466 11013263
BIRC5 CASP7 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11024045 16189514 11170436 9850056
FHOD1 RAC1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 15051728 15642356 11590143
HIF1A MTA1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16969516 16511565
DCTN1 DCTN3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 26638075 9722614 32814053 33961781 27173435
DCTN2 DCTN5 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 33961781 27173435 26186194 26344197
BCOR RYBP â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16943429 28514442 26687479 27505670 34316702 27705803 22325352 33961781 24981860 26186194
IRAK1 IRAK4 â—¼   PHYSICAL_INTERACTION 891.0 0.89 STRING 36370105
ADRB2 ARRB2 â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
DAXX TP53 â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
HDAC1 RELA â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
AKT3 BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 14766748 15642728 17525161
CTNNB1 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17404573 16288908 12782598
ESR2 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19211725 18223478 20664923
E2F1 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11559537 18319725 11704823
BCOR BCL6 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 23911289 16713569 15004558 33468080 26496610 18280243 10898795 20807888
NCOR2 BCL6 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 23911289 15454082 26728228 9380707 9824158 9765306 11865059 15531890 14690607 10898795 16147992 10611298
TP53 BCL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23852341 19427386
BCL6 IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21106671 12594267 15507530
NFE2L2 CASP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16189514 10510468
CASP3 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9348292
CBX1 CBX3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 17314413 11336697 16713569 27705803 33961781 21888893 24981860 34079125
CBX5 CBX3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 17314413 11336697 16713569 20850016 27705803 20231385 33961781 21888893 24981860 15306854 34079125 20562864 19498464
MYC CBX3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12747840
E2F1 CBX5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12629508
MYC CBX5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12747840
CSNK2A1 CBX5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21245376
TP53 CDC25A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 18281511 17001315 19060337
HIF1A CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19342889 20138114 19940121
ESR2 CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19487281 14729654 23907131
ESR1 CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17163418 17681750
E2F1 RELA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24755270
E2F1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19276347 21625432
E2F1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11564866 18319725 90001421
E2F1 CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15240700 12389032 18319725
MYC EP400 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 18413597 17314511 11509179 21150319 35140242 29467282 30415952 20946988
EP400 KAT5 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 27153538 11509179 20070254 33961781 26186194 23266955 17704809 20351180 29028833 20946988
EP400 KAT5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20351180 14966270
CDC42 GRB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
JAK2 GRB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 7500025 17474147 8536716 8950973
HSF1 HSP90AA1 â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
HRAS HSP90AA1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16024644 15118125 15284455
MYC HSP90AA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 28914785 12644583
HSP90AA1 BIRC5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 14614132 15894266 15218035
ESR1 KAT5 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31527615 17418098 16260778 22081016 11591700
MYC HDAC1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 17314511 18271930 34147029 26496610 30415952 18003922 22286234 24951594
WT1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15286719 17634147 20842112
RB1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 7680889 10200487 9671466
MYC AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16846534 16489011 18562319
MYC LMNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC ARF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
NOTCH1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 2191300 18490439 19219071
RELA MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12027803 16713569
HDAC1 PML â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 16713569 11259576 18644863 25812002 11430826 23563092
NCOR1 PML â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11430826 10882117 16713569
TP53 PML â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14992722 18056437 14715247
ESR1 STK11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21689749 22226967 18414489
TP53 FGF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 8090761 10029407
ESR2 TP63 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20034404
TP63 IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 27132513 8258457 23071313
CYTH1 ARF6 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 10652308 11050434 1511013
IRAK4 IRAK1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 24735611 12860405 19166926 18221795 12538665 17785851 11960013 16024789 16951688 17276401 21903422
ARF1 CYTH1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18451304 9707577 10652516
CYTH1 ARF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9756891 9653114 10212218
NOTCH1 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18722525 23331499 16256737
HIF1A HDAC1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 17273746 11641274 16511565 21148070 24015760
ESR1 HDAC1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 17312152 31527615 24051437 33731348 14722073 21182205 15557281 18451880 14506733 15140878
MTA1 HDAC1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 16189514 27098840 21258344 33264408 9885572 26028330 26496610 14722073 20585571 21670149 22939629 18451879 34026424 23752268 29997244 16511565 26949739 10840944 33961781 11146623 24981860 17922035 12920132 26344197
CUL3 HDAC1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 15467454 15688063 17312394
BCOR HDAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16713569 10898795
NCOR1 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16713569 24051437 12145334 16469706 17400812 12738788 21182203
AKT1 NCOR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 23940660
CTCF NFE2L2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22951020
AKT3 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19609947
RELA WT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9572484 11243407
AKT1 DCTN1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
ESR2 FOS â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20155458 10037443
DCTN1 DCTN2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 26638075 33961781 22956769 26186194 27173435 34079125 22939629 26344197
DCTN2 DCTN3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 22863883 33961781 27173435 26186194 34079125 22939629
MTA1 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16807247 31527615 12167865 12639951 11146623 18451880
ESR2 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 29509190 12630920 17991765 21182203 19022902 10706629 19746436 9473491
NCOR2 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17591692 23015261 15802375
ESR1 CYP2B6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20079471 18414489 22484313
ESR1 FGF7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15781986 14999240 15311216
ADRB2 ARRB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 23208550 24658140 17148612 24561123 27226565
ARRB2 ARRB1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 24069330 17353931 33961781 17620599
WT1 SF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14580722 12213901 12130543
ESR2 TGM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20034404
HSP90AA1 TP53 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
DNM2 GRB2 â—¼   PHYSICAL_INTERACTION 903.0 0.9 STRING 36370105
NUP153 NXF1 â—¼   PHYSICAL_INTERACTION 903.0 0.9 STRING 36370105
NUP107 NUP153 â—¼   PHYSICAL_INTERACTION 903.0 0.9 STRING 36370105
ACTR1A DYNC1H1 â—¼   PHYSICAL_INTERACTION 907.0 0.9 STRING 36370105
BCL6 NCOR2 â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
KIF5B KLC4 â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
MTA1 HDAC1 â—¼   PHYSICAL_INTERACTION ✅ 0.91 0.91 mint 6613464 18451879
KAT5 MRGBP â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
KIF5B KLC2 â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
ACTR10 DCTN1 â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
JAG1 NOTCH1 â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
HIF1A HSP90AA1 â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
HSP90AA1 LRRK2 â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
AKT1 ARRB2 â—¼   PROTEIN_INTERACTION 0.92 0.92 HIPPIE 18191226 19122674 19262695
DCTN2 DCTN3 â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
HDAC1 RB1 â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
DAXX PML â—¼   PHYSICAL_INTERACTION 926.0 0.92 STRING 36370105
HDAC1 TP53 â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
KPNB1 NXF1 â—¼   PHYSICAL_INTERACTION 931.0 0.93 STRING 36370105
IPO5 RAN â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
KPNA4 KPNB1 â—¼   PHYSICAL_INTERACTION 940.0 0.94 STRING 36370105
AKT1 HSP90AA1 â—¼   PHYSICAL_INTERACTION 946.0 0.94 STRING 36370105
RB1 HDAC1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 6550000 10779361
KLC4 KLC2 â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 22863883 30217970 26496610
EP400 KAT5 â—¼   PHYSICAL_INTERACTION 950.0 0.95 STRING 36370105
EP400 MRGBP â—¼   PHYSICAL_INTERACTION 951.0 0.95 STRING 36370105
DCTN1 DCTN3 â—¼   PHYSICAL_INTERACTION 951.0 0.95 STRING 36370105
ACTR3B ARPC2 â—¼   PHYSICAL_INTERACTION 954.0 0.95 STRING 36370105
ACTR1A DCTN5 â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
BCL6 NCOR1 â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
DYNC1H1 DYNLRB1 â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
ACTR1A DCTN1 â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
NUP153 NUP50 â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
KPNB1 NUP153 â—¼   PHYSICAL_INTERACTION 962.0 0.96 STRING 36370105
ACTR2 ACTR3B â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
DCTN2 DYNC1H1 â—¼   PHYSICAL_INTERACTION 967.0 0.96 STRING 36370105
CBX1 CBX5 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 17314413 11336697 27705803 24981860 21888893 20562864
RB1 E2F1 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 5219804 17380128
DAXX PML â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 30292834 21482821 21474068 10669754 14517282 12529400 20972456 15350595 10545115 21779164 11244500 32545337 17081986 12595526 15710327 21840486 17419608 12150977 24637324 10684855 17360386 10525530 23222847
FLNB FLNA â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 22939629 26344197 12393796 26496610
DAXX HDAC1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 24550390 12529400 10669754 29084956 32545337
HIF1A VHL â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 15082527 11865071 11226425 10944113 14556007 11986208 15527772 17973296 12538644 26735336 24899725 12606543 21358672 24015760 16611863 23401859 18062927 21332579 15805242 19940151 12086861 27281823 23413029 33060856 11292862 24316222 16155211 24857547 22932900 29121446 11292861 12101228 15060148 18047470 16278378 21602890 27320910 12464182 26611735 32589900 18402654 25500545 12050673 18694926 26215701 10878807 25361009 11641274 22351759 34007068 18305400 21316481 11024059 34195792 26037477 34174286 33039559 10823831 26743088 31810986 10353251 15833858 17558023 11566883 23580587 27563096 18985005 19123984 25438054 12682018 18323857 23387829 17442832 33550096 18222538 18426857 17047048 12004076 34230460 23318261 33961781 12808024 21335603 12586829 17353276 11358837 28514442 20724477 16140212 12205091 20049704 16862177 11331613 32535973 15721254 14691445 15385570 10973499 15611064 17981124 28775317 12925778 26496610 17339318 30237125 20458141 20639890 17986458 19147576 28425505 11504942 22369643 18264140 16511565 12351678 14600153 30988076 17132228
ACTR3B ARPC1B â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
ARF1 CYTH2 â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
CSE1L RAN â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
BAX BCL2 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
DCTN1 DCTN2 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
DCTN2 DCTN5 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
ACTR10 DCTN5 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
BAX BCL2 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 21778226 18981409 15899854 32064756 10620799 21199865 17289999 9194558 8358790 21671007 16642033 21458670 22262057 9388232 10716992 20865015 14980220 9111042 24141421 17097560 15231068 9463381 33961781 17525735 29749471 23479509 26004684
IPO5 RAN â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 10944119 9114010 26344197
ACTR10 ACTR1A â—¼   PHYSICAL_INTERACTION 990.0 0.99 STRING 36370105
DCTN1 DYNC1H1 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
HDAC1 MTA1 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
ACTR1A DCTN2 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
KPNB1 RAN â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
ACTR10 DCTN2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ACTR2 ARPC1B â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
ACTR2 ARPC2 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
ACTR2 ARPC2 â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 10467124 10511705 10783245 11395419 11520460 12177428 12194823 14707117 15001467 15541654 16293614 16606694 17306570 19741094 21178402 23212475 8625410
BCL2 BAX â—¼   PHYSICAL_INTERACTION 15.0 1.0 ACSN 11704864 16227588 17446862 17891140 20709625 21641962 22039431 23064052 23377657 23430059 23850759 7644501 8358790 8929532 9872359
BCL2 BAX â—¼   PROTEIN_INTERACTION 15.0 1.0 ACSN 11704864 16227588 17446862 17891140 20709625 21641962 22039431 23064052 23377657 23430059 23850759 7644501 8358790 8929532 9872359
HIF1A BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18366759 17558861 15706354 24349374
E2F1 BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9748148 11095619 12370749 14514686 15255934
TP53 BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 74.0 1.0 Omnipath 11278953 12203124 16931621 9582019 17693666 11118038 12433990 11395510 8183578 11429705 10400708 15242522 11423991 19067706 24336083 18381427 22732402 15988033 16341121 10935506 10094833 16215989 17280505 10744634 12851404 20673369 15851483 8845569 10559267 12168779 11850816 19505426 8564971 11756653 19054058 15566940 12173040 17690113 8635454 18034190 10510469 10101800 11335718 23100276 9400998 9445173 9582400 24098340 22532570 9122197 11420692 11104574 15679092 11748232 12560513 11928223 20400479 20546728 17145718 20567883 20840522 18172861 10566557 10777477 7834749 12806965 17521288 19242108 9000137 21859835
RELA BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18034190 18158998 20056115
MYC BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8845569 11103792 12695333
AKT1 BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 26763134 14766748 15642728 17525161
BCL2 BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 60.0 1.0 Omnipath 17145710 22705850 18981409 9463381 21458670 17097560 17525735 8358790 10620799 26004684 29749471 9388232 21199865 17525161 22262057 21778226 15486085 17289999 9111042 12419244 9194558 15231068 10716992 8183370 14980220 9115213 21671007 16642033 23479509 10677502
TP53 BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14963330 16151013 7834749
CUL3 BCL2 â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 15703371 16697054 17312394 17884153 18931676 19560419 19622404 19686080 19809470 19818716 19847258 23030059 23850759
BCL2 GRB2 â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 11463391 11463392 11532940 11704864 12566895 12667443 14764585 15516985 17446862 19289794 19565474 22039431 23064052 23377657 23430059 23850759 24027568 8929532 9069260 9872359
MYC BCL2 â—¼   DOWN_REGULATES ✅ - 17.0 1.0 ACSN 11274345 11283613 11283614 11704864 17055429 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21406394 2191300 22067385 25002027 28536364
RELA BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 17673602 18031796 12835724 15120608 20332461 14978135 20446017 18566231 19259124 14739605 21503108 20103608 17098279 18158998 19233129 16022909 18761399 18191642 21224428 16453001
MYC BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 8036017 17404573 12695333 24167291 18809243 19201832 16316993 19649202
ESR1 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 19148464 19160418 9306964 11261829 21841772 10542244 20664923 18414489
WT1 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16760668 9235968 10406804 12644474
E2F1 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17404573 11559537 12679318
TP53 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 41.0 1.0 Omnipath 17693666 8183578 10037739 16738310 18397889 19521340 18487508 21666495 16294215 21656028 22869582 19714248 10744634 8174112 17592775 11782367 19137013 20428827 18682598 11713302 11313951 20501806 9649502 24814047 15767042 24098340 11193470 10329733 21859835 22266868 10953306 19555669 23638218 14684736 19411072 20530667 24155778 8205530 20840522 9000137 15326476
CASP3 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 10409669 9395403 20139069 11948397
TP53 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 12667443 19555669 8205530 19007744 11313951
AKT1 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 21303971 11882383 17680028 20214616 22094462 20398329 21506126 20028971 12040186 18218901
AKT3 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 21303971 11882383 17680028 20214616 22094462 20398329 21506126 20028971 12040186 18218901
BCL2 CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 16183855 11406564
NCOR1 BCL6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15454082 16147992 9824158 16713569 10898795 11865059
NCOR2 BCL6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 17145710 9380707 15531890 10611298 15454082 23911289 16147992 9824158 10898795 14690607 11865059 9765306
TP53 CASP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 22154326 22178888 23677569 15578696 17363498 24098340 18064040 23527225 10893263 21859835
E2F1 CASP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18660752 12389032 18319725
CASP8 CASP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 15755874 17179148 9501089 9950028 18669646 23308069 10988287 18458084 16964285 9885230 9765224 11437602 15014070 21295084 8962078 9208847
BIRC5 CASP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 9384571 11024045 9850056 10587640 16189514 16540654
CASP3 RB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 10822366 11420704 9092486
CASP3 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 17544405 12124386 10579725
CSNK2A1 CBX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19657222
E2F1 CDC25A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11154267 11799067 19633359
MYC CDC25A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 8994810 10205150 11154267 9371770 14519204 15677471 17671423
MYC CDC25A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 8425218 15121849 11602341 2006410 17873522 21406394 12584560 17558397 20551172 15814658 16908182
RB1 CDKN1B â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 Reactome 10207050 9447971 24876129 31543423 11416152 11032757 9190208 30711375 10499802
TP53 CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15145945 15988033 19235838 10516009 21478095 14984207 19427386
E2F1 CDKN1B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15713665 21840777 22955272 23393547 19077036
TP53 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21340684 20066118 20457558 20182602 6396087
AKT1 CDKN1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 69.0 1.0 Omnipath 22119715 11756412 16780593 11923280 16697215 16209941 12244303 20398329 18372248 14967450 18710949 15808505 26053093 20138985 14504289 20214616 12244302 17570479 18593906 23576547 23400686 12851486 15169778 24651496 19829074 25241761 10949026 16288292 11715018 18636226 19377290 9812896 12042314 17680028 10722653 20832730 18570873 12244301 17052453
DCTN3 DYNC1H1 â—¼   PHYSICAL_INTERACTION 28.0 1.0 Reactome 17274799 9490716 10679020 10562278 11306556 24891604 16723730 18086915 17283181 18664496 11035033 25453831 18046453 11285137 19564404 8642258 12198549 15728195 10903204 15878873 7691276 8909537 23839779 9150144 10559986 25233431 10036229 24806965
DYNC1H1 ACTR10 â—¼   PHYSICAL_INTERACTION 28.0 1.0 Reactome 17274799 9490716 10679020 10562278 11306556 24891604 16723730 18086915 17283181 18664496 11035033 25453831 18046453 11285137 19564404 8642258 12198549 15728195 10903204 15878873 7691276 8909537 23839779 9150144 10559986 25233431 10036229 24806965
E2F1 RB1 â—¼   PHYSICAL_INTERACTION 18.0 1.0 ACSN 11877377 15175241 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 19793801 20029420 21060331 21337561 24254977 7575488 7935440
E2F1 RB1 â—¼   PROTEIN_INTERACTION 18.0 1.0 ACSN 11877377 15175241 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 19793801 20029420 21060331 21337561 24254977 7575488 7935440
E2F1 RB1 â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 11877377 15175241 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 19793801 20029420 21060331 21337561 24254977 7575488 7935440
TP53 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 21715977 20805247 8557038 11795482 17210690 22952705
ESR1 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22791811 20215421 12697671 10446910
E2F1 BIRC5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23449974 19497660 15271987 16601104 17848598 19102934
E2F1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 8208548 2721961 7753559 11705881 24038073 8355712 1549358 1567856 12629508
E2F1 RB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 11533237 16081466 16738312 16188218 15618023 14681231 16230367 15985428 8264596 18583990 16601104 14627987 15016799 11268000 10490838 11818069
E2F1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 22241525 8557038 15706352 21441950 12675512 23954287 12625370
RB1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 90.0 1.0 Omnipath 17145710 23472054 12502741 22078878 8896460 12397079 9315635 20839231 16249186 11839806 8255752 11713253 20871633 15837424 8346196 19249677 16360038 8626527 12096339 15485814 16374512 18391203 9125176 16766265 9468140 8816798 12598654 10393912 9400991 9632788 12947005 19477924 15485920 17380128 10523633 10869426 7828850 18216119 8657117 12963846 25257171 17488475 28074012 15670817 11583618 7739537 10499802 8413249 11090181 8230483 22768064 29521627 10207050 9553123 7958924 11420730 23001041 16496386 9501179 19058874 1388726 9422723
E2F1 CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18660752 12389032 18319725
E2F1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22480684 11739724 12625370
KAT5 EXO1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
GRB2 RAC1 â—¼   PHYSICAL_INTERACTION 32.0 1.0 ACSN 10086337 10567412 10811803 10982827 11274345 11447289 11756498 11777939 12040186 12175651 12640133 12738796 14585353 15567848 15574420 15863030 16102570 16582911 16887996 17496910 17673906 18000759 18855897 19151919 19449109 19568798 21614932 24027568 26552706 27331412 7510700 8551221
GRB2 KDR â—¼   PHYSICAL_INTERACTION 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
GRB2 RAC1 â—¼   SHARES_COMPLEX 32.0 1.0 ACSN 10086337 10567412 10811803 10982827 11274345 11447289 11756498 11777939 12040186 12175651 12640133 12738796 14585353 15567848 15574420 15863030 16102570 16582911 16887996 17496910 17673906 18000759 18855897 19151919 19449109 19568798 21614932 24027568 26552706 27331412 7510700 8551221
GRB2 KDR â—¼   SHARES_COMPLEX 52.0 1.0 ACSN 10022831 10086337 10567412 10811803 10849428 10982827 11166270 11447289 11449354 11532940 11777939 11960372 12175651 12393695 12629515 12640133 13678960 15099563 15111329 15501236 15520864 15567848 15573129 15574420 16002046 16076871 16572188 16582911 16887996 17086423 17496910 17673906 17883421 19414323 19449109 21372296 21378271 22064427 22461508 23390297 23896411 24217602 24346288 24670066 25922287 26201938 26552706 8551221 8837607 9157999 9570538 9753319
HRAS GRB2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
FOS GRB2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11274345 12738796 15067049 16393692 16394015 18039929 19667062 21385848 22634314 23430059 9064320
JAK2 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8536716 8950973 7500025 17474147 19273609
KDR GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9405464 16966330 10319320
GRB2 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17496910 16713569 17673906 11352655
HSF1 IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23733891 23636453 24532586 10328874 11893605 22105779 11866474 17766920
HSF1 HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9880553 21932106 10440232 19818013 20045681 20668218 15706094 17965413
CSNK2A1 HSF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12659875 15302935
TP53 HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15358769 15284248 24451373 18996350
HSP90AA1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 12427754 10557093 21460846 16713569 11507088
HSP90AA1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 19356729 18266962 10995457 25714412 16189514 12176997 12586360 15843522
IKBKE ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23816933 20863366 19940156
IKBKE RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 28317833 12842894 16046471 20188669 15128824 17561400 17003035 30223576 15485852 10521409 15489227 15849198 16407239 26025205 15212693 12767944
CTNNB1 KAT5 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9843967 14695187 16510874 15829968 11080158
PML KAT5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19150978
KAT5 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17188038 15310756 18280244 16601686
KAT5 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12776177 19150978 15572685 34650217
TP53 MKI67 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 21611785 11713584 10365096 15217513 16258956 14675138
MYC HIF1A â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 10432118 11274345 11283614 11875494 16327802 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21093321 21372296 21406394 21765015 2191300 22067385 22461508 23124025 23390297 25002027
CTCF MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 10625678 8649389 2284094 12032779 19568426 24725430 12524457 8246978 12897849 9591631 1795697
RELA MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 12894581 18184402 7869034 17673602 12783888 11114727 17944672 9596659 19469019 21790895 19766095 17018379 8289784 18566231
FOS MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11939505 2463066 1696944 8276360 9950153 2139817 2498162 21607323 20410304 8490168 7654239
HIF1A MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 20404562 23059786 19845622 18616527 15780936 21303984
CTNNB1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 21533051 19778454 16510874 12095419 17360646 18852287 15576399 19561604 20300972 19662654 15579438 17724465 9727977 24447505 18679417 12907606
ESR1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 22396492 21835891 15073177 18193094 11517191 21505052 22892083 8707895 19569049 14722073 18414489
MYC TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 10962037 10656696 8494784 10348347 19882681 16557594 19086036 15780936 14519204 16112647 11781835 7969121 11789587 9839551
MYC CASP8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15367674 12695333
MYC NPM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15589822 16857742 14519204 23271972 11983916 11085504
MYC VHL â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22286234 12695333
MYC BIRC5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17170079 19287963 20508797 19602047
CHUK MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17306568 17666529 23343194 21285352 15576399 21151179 22761862 22290435 16039586 19619488 19623618 17143292
HDAC1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 21734722 17666529 15576399 22761862 22290435 19923891 20682799
CTNNB1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 19751508 7542250 11967263 22290435 19623618 16574648 23343194 11955436 22270359 22761862 16039586 15810077 17143292 12051714 8666229 22943793 15576399 21151179 16940750 17306568 17666529 21285352 19619488
MTA1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 21734722 17666529 15576399 22761862 22290435 19923891 20682799
NPM1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 23443559 15144954 16740634 15310764 16376884 12080348
CSNK2A1 PML â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 17145710 16873060 19380586
STK11 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 20815019 11430832 17108107 16713569
ESR1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 20080630 16115928 22787161 12750288 20696891 17681750 17699779
HIF1A TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 12542982 17390008 9537326 15780936 11696352 10469629 17236590 20706634 15629713 11007955
RELA TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 18269916 10348347 11032029 8051093 20061391 15155458 21332394 9890939 21887328
TP53 BIRC5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 27.0 1.0 Omnipath 19363521 19470765 19067706 17124180 11714700 16432013 18698017 21443519 12235242 20236666 22266808 16595680 15361831 23838170 17916908 15087401 15377848 19018856 19439469 22503977 17699779 11965534 15657147 18022393 18027854
TP53 CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 11564862 20697347 20729811 21691299 19411072 24473123 20064927 18245266 18758483 18372914
TP53 FOS â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 8604347 17174366 8668332 1946467 10082525 10214938 1508692 8649776 10529369 12173040
TP53 CHUK â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15469934 11557753 17434128
TP53 HRAS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21552926 9662334 11127813 21552928
TP53 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12485897 18661553 19763735
TP53 TP63 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 10606233 16931914 18388131 16516862 14576823 11382762 20442293 23019126 19858204 11238924 11423969
TP53 RB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 11850820 10029406 16931621 9774636 8845569 8270002 11244564 15618023 12444079 12749855 21496227 11818069 15827088 8720930 1608930 8119988 23474762 11121443 22729911 22894933 8355507
CSNK2A1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 53.0 1.0 Omnipath 23443559 15358769 9315650 19413330 11285227 11551930 11883897 22975381 11709713 16083285 1088347 33745968 16552184 10884347 10747897 10673501 7936649 12628923 25241761 21127074 16964247 24725084 10606744 10348343 10951572
WT1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 16713569 10744705 8389468
HDAC1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 17145710 10521394 11099047 22266186 20633551 18765668 20075864 17827154 11313951 14976551 25241761 19303885 12426395 19011633 16697957 16959611 16107876 10777477
DAXX TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 12954772 21482821 21134643 16845383 25241761 15364927 16713569 12482984 15339933 23038753
TP53 TP63 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11238924 18431400 16713569
TP53 BIRC5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 19211844 11965534 11714700
TP53 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 9537326 16713569 12124396 15629713 16882692
TP63 JAG1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23863842 11641404 23837456
RAN KPNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 17145710 10779340 8909533 11024021 9214382 20658144 8576188 26496610 9102465 9135132 10944119 10037787 9045717
CYTH2 ARF6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9417041 16189514 14565977
DCTN1 DYNLL2 â—¼   PHYSICAL_INTERACTION 28.0 1.0 Reactome 17274799 9490716 10679020 10562278 11306556 24891604 16723730 18086915 17283181 18664496 11035033 25453831 18046453 11285137 19564404 8642258 12198549 15728195 10903204 15878873 7691276 8909537 23839779 9150144 10559986 25233431 10036229 24806965
DCTN2 DYNLL2 â—¼   PHYSICAL_INTERACTION 28.0 1.0 Reactome 17274799 9490716 10679020 10562278 11306556 24891604 16723730 18086915 17283181 18664496 11035033 25453831 18046453 11285137 19564404 8642258 12198549 15728195 10903204 15878873 7691276 8909537 23839779 9150144 10559986 25233431 10036229 24806965
DCTN3 DYNLL2 â—¼   PHYSICAL_INTERACTION 28.0 1.0 Reactome 17274799 9490716 10679020 10562278 11306556 24891604 16723730 18086915 17283181 18664496 11035033 25453831 18046453 11285137 19564404 8642258 12198549 15728195 10903204 15878873 7691276 8909537 23839779 9150144 10559986 25233431 10036229 24806965
ACTR1A DYNLL2 â—¼   PHYSICAL_INTERACTION 28.0 1.0 Reactome 17274799 9490716 10679020 10562278 11306556 24891604 16723730 18086915 17283181 18664496 11035033 25453831 18046453 11285137 19564404 8642258 12198549 15728195 10903204 15878873 7691276 8909537 23839779 9150144 10559986 25233431 10036229 24806965
DYNLL2 DCTN5 â—¼   PHYSICAL_INTERACTION 28.0 1.0 Reactome 17274799 9490716 10679020 10562278 11306556 24891604 16723730 18086915 17283181 18664496 11035033 25453831 18046453 11285137 19564404 8642258 12198549 15728195 10903204 15878873 7691276 8909537 23839779 9150144 10559986 25233431 10036229 24806965
DYNLL2 ACTR10 â—¼   PHYSICAL_INTERACTION 28.0 1.0 Reactome 17274799 9490716 10679020 10562278 11306556 24891604 16723730 18086915 17283181 18664496 11035033 25453831 18046453 11285137 19564404 8642258 12198549 15728195 10903204 15878873 7691276 8909537 23839779 9150144 10559986 25233431 10036229 24806965
ESR1 KDR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16574784 18006642
ARPC1B ARPC2 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
IRAK4 IRAK1 â—¼   PHYSICAL_INTERACTION 30.0 1.0 ACSN 10679398 11274345 11592085 12620219 12682231 12738796 14504095 14660645 14662834 15099563 15125833 15802534 16252010 16878026 17704786 17948050 18264787 18758450 18855897 18922473 18977329 19161412 21614932 23070005 23681101 23811849 26885855 27048821 27066895 9469432
IRAK4 IRAK1 â—¼   SHARES_COMPLEX 30.0 1.0 ACSN 10679398 11274345 11592085 12620219 12682231 12738796 14504095 14660645 14662834 15099563 15125833 15802534 16252010 16878026 17704786 17948050 18264787 18758450 18855897 18922473 18977329 19161412 21614932 23070005 23681101 23811849 26885855 27048821 27066895 9469432
IRAK4 IRAK1 â—¼   ENZYMATIC_REACTION ✅ 30.0 1.0 ACSN 10679398 11274345 11592085 12620219 12682231 12738796 14504095 14660645 14662834 15099563 15125833 15802534 16252010 16878026 17704786 17948050 18264787 18758450 18855897 18922473 18977329 19161412 21614932 23070005 23681101 23811849 26885855 27048821 27066895 9469432
IRAK4 IL6 â—¼   ENZYMATIC_REACTION ✅ 25.0 1.0 ACSN 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 9743347
IRAK4 IRAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 17145710 17785851 18252867 17276401 16024789 14625308 15084582 21903422 15292196 25452754 19775907 18221795 15905496 19166926 12538665 12860405 14751757 12496252 11960013 24735611 26143580 17337443
JAK2 IL6 â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
JAK2 IL6 â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
JAK2 IL6 â—¼   ENZYMATIC_REACTION ✅ 35.0 1.0 ACSN 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545
HIF1A IL6 â—¼   ENZYMATIC_REACTION ✅ 21.0 1.0 ACSN 10804084 15749903 16110315 16127144 16243976 16413922 17485448 17533374 20427344 20535745 20855962 21051947 21765015 22006996 22850421 22988108 24006507 25043024 25103413 25732824 9743347
FOS IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 10037779 10542237 9671466 2511437 25567680 20351184 24994901 11356008 11028561 12667961 18502099
RELA IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 114.0 1.0 Omnipath 26596471 19124729 10373597 9523851 23595969 28270510 21537341 17982049 15226358 18243142 12200447 20371366 24664372 23874122 14532843 18942706 10975857 21278793 10469356 22547075 17490702 11459775 23335080 10569191 19707556 19687301 7499267 8290595 23857586 24676671 18061164 11058167 12887736 15013753 15158360 22661093 20935672 20511231 17350185 10903137 16112536 27413250 21810609 16984731 16166627 18469854 12881425 24012417 23386688 22105366 8752656 12176740 27371733 22578249 18057724 20351184 10329846 19164127 10542237 11564778 20221401 15517885 19122653 20534538 7876168 27211851 9516466 18996370 8824277 18310089 21104991 25888873 12359431 11327783 20066113 20100571 19703987 19469019 21106671 16960103 18502099 16043358 21996739 20650996 22021035 11120852 12672795 12058956 18483242 22189669 14976218 17495236 11007957 21131967 11975924 27337441 9182853 10963848 17040605 11504280 15756023 10823821 17932106 19966855 20696864 12177065 8679226 9199307 17196927 20457835 21098092 17532054
HIF1A IL6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17548584 20003295 21258402 15913932 18791496
CYTH2 ARF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 14654833 17563369 8945478 16189514 10198630 9417041
NOTCH1 JAG1 â—¼   PHYSICAL_INTERACTION 21.0 1.0 ACSN 11955436 11967263 12051714 15001769 16039586 17143292 17936032 19567869 19619488 20351093 20705860 20940030 21841793 22330899 22363130 22363487 23343194 24023259 25730849 7542250 8666229
NOTCH1 JAG1 â—¼   SHARES_COMPLEX 21.0 1.0 ACSN 11955436 11967263 12051714 15001769 16039586 17143292 17936032 19567869 19619488 20351093 20705860 20940030 21841793 22330899 22363130 22363487 23343194 24023259 25730849 7542250 8666229
NOTCH1 JAG1 â—¼   LOCALISATION ✅ 21.0 1.0 ACSN 11955436 11967263 12051714 15001769 16039586 17143292 17936032 19567869 19619488 20351093 20705860 20940030 21841793 22330899 22363130 22363487 23343194 24023259 25730849 7542250 8666229
DLL3 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23331499 29910816 16921404 16140393 18676613 10958687 22353464
JAG1 NOTCH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 39.0 1.0 Omnipath 18495817 16921404 15137944 769772111006133 16713569 23331499 21071413 23086448 22363130 18988627 21820430 18292500 18660822 22330899 17537801 11006133 7697721 10958687 22353464
NOTCH1 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18560356 23331499 23180781
HDAC1 NCOR2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 ACSN 15465827 16127449 21234400 22796940
HDAC1 NCOR1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 ACSN 15465827 16127449 21234400 22796940
HDAC1 NCOR2 â—¼   SHARES_COMPLEX 4.0 1.0 ACSN 15465827 16127449 21234400 22796940
HDAC1 NCOR1 â—¼   SHARES_COMPLEX 4.0 1.0 ACSN 15465827 16127449 21234400 22796940
HDAC1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 21655924 23242655 18316616 20101232
CSNK2A1 HDAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 19651622 19415658 17081983 20166139 18767875 11602581 20068231 18452278 17287340 19413330 22113938 18669648
HDAC1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 11564889 11931769 16483679 30670829 16325585 16713569 17183360 21983014
NCOR1 NCOR2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 ACSN 15465827 16127449 21234400 22796940
NCOR1 NCOR2 â—¼   SHARES_COMPLEX 4.0 1.0 ACSN 15465827 16127449 21234400 22796940
NCOR1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 16469706 12738788 12145334 17400812 16713569 21182203
KLF5 BIRC5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16595680 23869764
RELA BIRC5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17553314 20126979 14739605
HIF1A BIRC5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22925504 16847054 19245702 23732337
CTNNB1 BIRC5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19778454 17005722 19662654 11517919 16288908
BIRC5 CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 9384571 11024045 9850056 16189514 11170436
CUL3 NFE2L2 â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 15703371 16697054 17312394 17884153 18931676 19560419 19622404 19686080 19809470 19818716 19847258 23030059 23850759
CSNK2A1 DAXX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21474068
CASP8 CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 18073771 9545235 10872455 18329793 9727491 9463409
NFE2L2 GSTA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 22459801 16551619 17077087 24024136
CHUK RELA â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 9315679 9914500 9721103 10593898 9135156
AKT1 CHUK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 15710601 12048203 25241761 19442713 11278366 10485711 15800029 19609947 17570479 17660512 18515365 19088076 10485710
CHUK NCOR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 18374649 16846590 23041317 23343355 16382138 15494311
CHUK RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 49.0 1.0 Omnipath 17145710 15611276 22110409 19609947 10521409 20863851 20051109 20363318 12767944 26999213 12842894 21903422 19110719 15858576 16382138 22155370 23894194 16046471 15128824 21569639 16846590 8246997 15485852 25341660 15494311 11983155 15980040 15489227 15849198 14636585 23343355
RELA AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20186924 18031796 20649564
RELA HIF1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18498249 17898080 23185316
CSNK2A1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 34049972 15016307 10938077 27630163
RELA NCOR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 10777532 14982881 12589049 16382138
RAC1 AKT1 â—¼   ENZYMATIC_REACTION ✅ 45.0 1.0 ACSN 10722653 10949026 11274345 11715018 11756412 11756498 11923280 12408816 12906785 15169778 15808505 16469695 16697215 17052453 17461779 17680028 18000759 18372248 18492954 18570873 18636226 18925875 19022819 19143635 19151919 19568798 19720745 20027184 20138985 20214616 20338997 20398329 20832730 21157483 21474067 21981924 23087689 24795729 24973821 25002027 25730849 26159692 27331412 28216025 9812896
RAC1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 19751508 28626389 26403202 19417647 22270359 16212495 16940750 12480336 11152757 29497040 30650643 19020303 15377999
RAC1 FHOD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15642356 15051728 11590143
RAC1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 34.0 1.0 Omnipath 18000759 20027184 21157483 11756412 11923280 16697215 20398329 17461779 18372248 20338997 15808505 20138985 20214616 21474067 19568798 15169778 19720745 18925875 10949026 11715018 19143635 12393431 18636226 10617634 9812896 17680028 19151919 10722653 20832730 18570873 17052453 12408816 11274345
LRRK2 KPNB1 â—¼   PHYSICAL_INTERACTION 20.0 1.0 ACSN 10089876 10811803 10898494 11030334 11148124 11262396 11274345 11402342 11406367 14627704 17593948 17662023 18287025 19836308 21709260 21983832 7650486 8068174 9374532 9973469
KPNB1 CSE1L â—¼   PHYSICAL_INTERACTION 20.0 1.0 ACSN 10089876 10811803 10898494 11030334 11148124 11262396 11274345 11402342 11406367 14627704 17593948 17662023 18287025 19836308 21709260 21983832 7650486 8068174 9374532 9973469
LRRK2 KPNB1 â—¼   SHARES_COMPLEX 20.0 1.0 ACSN 10089876 10811803 10898494 11030334 11148124 11262396 11274345 11402342 11406367 14627704 17593948 17662023 18287025 19836308 21709260 21983832 7650486 8068174 9374532 9973469
KPNB1 CSE1L â—¼   SHARES_COMPLEX 20.0 1.0 ACSN 10089876 10811803 10898494 11030334 11148124 11262396 11274345 11402342 11406367 14627704 17593948 17662023 18287025 19836308 21709260 21983832 7650486 8068174 9374532 9973469
LRRK2 KPNB1 â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 10089876 10811803 10898494 11030334 11148124 11262396 11274345 11402342 11406367 14627704 17593948 17662023 18287025 19836308 21709260 21983832 7650486 8068174 9374532 9973469
NUP153 KPNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17145710 35044719 10749866
LRRK2 CSE1L â—¼   PHYSICAL_INTERACTION 20.0 1.0 ACSN 10089876 10811803 10898494 11030334 11148124 11262396 11274345 11402342 11406367 14627704 17593948 17662023 18287025 19836308 21709260 21983832 7650486 8068174 9374532 9973469
LRRK2 CSE1L â—¼   SHARES_COMPLEX 20.0 1.0 ACSN 10089876 10811803 10898494 11030334 11148124 11262396 11274345 11402342 11406367 14627704 17593948 17662023 18287025 19836308 21709260 21983832 7650486 8068174 9374532 9973469
LRRK2 CSE1L â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 10089876 10811803 10898494 11030334 11148124 11262396 11274345 11402342 11406367 14627704 17593948 17662023 18287025 19836308 21709260 21983832 7650486 8068174 9374532 9973469
LRRK2 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 24916379 21658387
HIF1A VHL â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
VHL HIF1A â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18931676 18985005 19622404 19686080 19809470 19847258
HIF1A FGF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19492421 16399861 17536272 17942638
HIF1A VHL â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 12205091 15930297 21887475 22150821 22396654 15962286 23159849 17482131 17140440 16883594
HIF1A AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19144925 17220299 17488804 14726529 15277220
HIF1A HSP90B1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19828020 15620698
VHL HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 123.0 1.0 Omnipath 17145710 21332579 24857547 12682018 26496610 11292861 11024059 15060148 16278378 12586829 17353276 12004076 12205091 17339318 10823831 11226425 21602890 16862177 15611064 12351678 16140212 11865071 26037477 16611863 10973499 23401859 25361009 11331613 18305400 25438054 14691445 17047048 12538644 22932900 18985005 26735336 21358672 18323857 10878807 19147576 16511565 17973296 23413029 24316222 11986208 12808024 12464182 23318261 22369643 19940151 15721254 20724477 21335603 16391536 23387829 18694926 26743088 14556007 18264140 10353251 15082527 11358837 11292862 11566883 12050673 19123984 17558023 27281823 15805242 11641274 25500545 34174286 24899725 12606543 32535973 17132228 24015760 12086861 11504942 35589690 26215701 22351759 12925778 18222538 17986458 14600153 10944113 23580587 26611735 18426857 20049704
RB1 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15674338
ESR1 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11029009 15569929 18450422 20664923 15496458
CSNK2A1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 29732088 17374729 21506126 11689703 10671551 12149249 15818404 10747897 10837139 20976471 19662498 21285348 11035045 11707428 21735093 17444818 20558317 11972058 16707567
AKT1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 20858269 23331499 20028971 11882383 21303971 17680028 20214616 22094462 17287208 17374729 20398329 21506126 21402455 12040186 19623618 12063252 18218901
AKT1 IRAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 11976320
AKT1 EIF4EBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 17081983 11691836 18767875 12665511 19413330 10405182 19664995 10942774 9092573 20068231 9465032 11777913 18669648 8083223 12105188 17287340 9405468 12370290 19651622 10779345 10364159 12912989
AKT1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 18521086 26944939 11108261 17627277 20101208 17570479 15604293 23169992 26554417 16452229 15193262 7838153 12374744 11139588 26272591 11432835 20179234 11507039 9528769
AKT1 PDE3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 8163498 17570479 10454575 18669648 8626720
AKT1 ALYREF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18562279
AKT1 ADRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11809767 9032240
ESR1 FOS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 8114761 9528985 18414489 10037443 21813366 11726205
ARRB2 GNAI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 10508237 23109003 17084806 18538863 10644702 16183910 15337520
ARRB1 GNAI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 10508237 23109003 17084806 18538863 10644702 16183910 15337520
GNAI2 ADCY1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 2121366 8327893 19703466
GNAI2 ADCY5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 23109003 15539636 7935349 16460834 11376933
AKT3 CREB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 19216069 17680028 11756412 16680151 20214616 11463845 20452955 9829964 20398329 17646672 10217147
NUP153 NXF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10668806 16713569
CSNK2A1 NKX2-5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9858576
CSNK2A1 HNRNPC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 32.0 1.0 Omnipath 19651622 20058876 17081983 20166139 15687492 18691976 20068231 18452278 19664995 17693683 17287340 19413330 12564933 18669648 15302935
CSNK2A1 EIF4EBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 11146653 12588975 18212344 9806882
CSNK2A1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 11139588 26703694 9337862 20043841 11432835 11507039 9528769 7838153
CSNK2A1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 12700239 12432063
CSNK2A1 ARRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11877451 32863206
AKT3 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 21303971 11882383 17680028 20214616 22094462 20398329 21506126 20028971 12040186 18218901
MTA1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15226262 11146623 12527756 24413532
ESR2 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 14754635 24284820 15207704 18784357 11566442 12630920 22820289 19001520 18511514 14676837 19207817 22622808 21763263 18339713 15087130
ESR1 CYP1A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 16972788 16010691 17511620 15858227 15837795 20716622 22837390
NCOR2 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 12738788 14715875 9171229 9702189 20392877
MTA1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 11146623 18451880 12167865 16807247
ESR1 ESR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 12630920 9473491 19746436 21182203 10706629 10022879
ARRB2 ADRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 23208550 17148612 17666399 24658140 27226565 2163110 24561123 22364396