Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
ABL1 CDC27 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ABL1 SP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
JUN ABL1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9746785 15145216
JUN BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16229810 17434164
EP300 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23353771 23285190
MYC CBX5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
E2F5 CBX5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 21374739
E2F4 CBX5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18319725 12909625
E2F1 CBX5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18319725 12909625
CDC27 CCND1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0913813107 20439707
HDAC3 CCND1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16461912 0506281103
CCND1 E2F5 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 11157749 9144196
HDAC1 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20049841 20821348
E2F3 CDK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8033208 7958856
CDK2 MCM7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10523313 10373557
E2F2 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7958836
E2F1 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11799067
E2F1 MCM7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14990995
HDAC1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17980157 18319725
E2F1 RBBP4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18319725 12909625
E2F1 E2F2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15014447 18319725
E2F1 DNMT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18319725 15867357
E2F4 HMGB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17531812
CEBPB KAT2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23456364 17301242
TAF1 KAT2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17085686 9285713
E2F2 MCM7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14990995
E2F3 MCM7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14990995
E2F2 MCM7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18319725 14990995
E2F4 MCM7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18319725 14990995
E2F3 MCM7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18319725 14990995
PML MDM2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216620 12915590
MDM2 MDM4 â—¼   COLOCALIZATION 2.0 0.8 intact 17159902 5219425
MDM2 PML â—¼   COLOCALIZATION 2.0 0.8 intact 5216620 12915590
CEBPA MYC â—¼   DOWN_REGULATES ✅ - 2.0 0.8 ACSN 11340171 20581311
AHR MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11114727 16091746
E2F5 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17132729
MYC HDAC2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20697349
MYC TRAP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11983916
E2F2 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11564866 18319725
E2F3 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11564866 18319725
HDAC3 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22002311 18483244
E2F5 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12150994 18319725
MYC TFDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11139609
PML JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9671405 10620019
TAL1 RBBP7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0900437106 19497860
E2F4 RFC5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18319725 16135806
CDK6 E2F5 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 11157749 9144196
CDK6 CCND3 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
MYOD1 CCND3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10373569
LIN9 E2F4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219419 17159899
TFDP2 E2F4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5211277 10090723
E2F4 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11799067
E2F4 SP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17531812
E2F4 E2F3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17531812
CEBPB E2F4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16959612
E2F4 RBBP4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18319725 12909625
RAF1 BAG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8692945 5221106
TAL1 HDAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0900437106 19497860
SP1 HDAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12847090 5216518
HDAC1 CEBPA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16431920
TAL1 HDAC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0900437106 19497860
HDAC3 BAG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19595997 7216159
TBP JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17074809 21106530
SP1 CEBPA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10373535 12049196
SP1 TAL1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8058326 9786909
HMGA2 E4F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 14645522
CDK4 E2F5 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 11157749 9144196
CEBPA CDK4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11867521 11684017
CCND3 E2F5 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 11157749 9144196
E2F3 CCND3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12611887 18319725
E2F2 CCND3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12611887 18319725
TFDP2 E2F5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11157749 9144196
CDK2 P53 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 25241761 12064478 10747897 19556892 10348343 10884347
EP300 HDAC1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 14968110 30110629 22778253 16787918 33742100 18722353 22731250
ANDR KAT2B â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 10779504 11328859
TFDP1 E2F4 â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 24981860
RB HMGA2 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 16766265
PPIA RB â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 16189514 12210730
P53 LMNA â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 30419336 25144556 29568061
MYC AATF â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 30415952 29467282
EP300 ATF2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 10327051 24069158
DNMT1 CBX5 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17470536 12867029
ANDR CBX5 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33640491 34585037
CBX5 RB â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 11484059 15485920
CDK2 E2F4 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33961781 25852190
CDK9 P53 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 16741955 16552184 17942552
DYR1A EP300 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 30137413 23602568
CTBP1 EP300 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21102443 15834423 35016035 16122695
SP1 KAT2B â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 16050810 15647279
MYC RBBP4 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 30415952 29467282
MYC PHB â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 35140242 29467282
MYC PP1A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17314511 29467282
MYC RFC5 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17314511 29467282
MYC CTBP1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21150319 34147029
MYC DNMT1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 30415952 29467282
MYC JUN â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21150319 20232342
MYC RING1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 30415952 29467282
MYC TAF1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 35140242 26496610
RBBP7 SUV91 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 11788710
RFC5 RB â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
JUN HDAC1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17056544 25609649
HDAC1 RING1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 26496610
JUN GBLP â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 25609649 21860413
JUN P53 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31182485 25609649
MO4L1 LMNA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17573780 24623722
CTBP1 DYR1A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 35016035 26186194
TAL1 RB â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 19497860 10866689
TFDP1 RING1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 24981860 27705803
LIN9 TFDP2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33961781 17531812
LIN9 TFDP1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33961781 17531812
CC062 RB â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 26186194
SSF1 RB â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
RB ANC2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17187060 33971196
ANDR ZBT16 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 19762545 23798432
RFPL2 DYR1A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 26186194
BRCA1 CDK9 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 22990118 28278048
BRCA1 MAT1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 22493164 15282296
CCND3 CDK2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 16782892 33854235 26496610 9716181 33961781 26186194 23455922
CC062 EP300 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 35016035 26186194
MYC LMNA â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 21150319 17314511 29467282
ARI4A RBBP7 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 11283269 28514442 26186194 33961781
MO4L1 RBBP7 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 20332121 17573780 33961781 24981860 26186194
RBBP7 KDM5A â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194 24981860
RBBP7 LIN9 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194 24981860
TFDP3 RB â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
TFDP3 E2F3 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
TFDP3 E2F4 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
MYOD1 SMCA4 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 22068056 35140242 15870273 20195544
LIN9 E2F4 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 17671431 17563750 17531812 17159899 33961781
SMCA4 HDAC1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 19081374 20596014 12192000
HDAC1 KDM5A â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 23752268 33961781 26496610
RB CEBPA â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 18239623 15107404 10082561
MO4L1 KDM5A â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 17573780 33961781 24981860 26186194
UBF1 TBP â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 16713569 8552083
CTBP1 PRDM2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 31041561 33961781 35016035 26186194
RING1 RB â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 16189514 11583618
ANM2 RB â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 16616919
RFPL2 RB â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
LAP2A RB â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 12475961 16713569
CDK13 RB â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
TGM2 RB â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 16189514 9315663
RB GBLP â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 16189514 12761493
CCND1 EP300 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
EID1 EP300 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
BRCA1 CDK2 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
KAT2B MDM2 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
MYC SP1 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
PHB RAF1 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
CDK2 TFDP1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 33961781 9199321 25852190
E2F1 E2F3 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 35140242 24981860 20106982
DYR1B EP300 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 32707033 23602568
RB KAT2B â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 19249677 15044952
EID1 MDM2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 24167073 11073989
MYC FZR â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 21150319 28628118 28205554
TAF1 P53 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 16713569 15053879 10359315
CEBPA HDAC1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 15713621 22355045 23898169
HDAC1 ARI4A â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 11283269 10490602 23752268 28514442 26496610 33961781
HDAC3 RB â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 10490602 16189514 10958676 12479814
CEBPB SP1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 16651265 12847250 12665574
SP1 RB â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 11158299 10850422 7732011 11896613
MK14 CDK4 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 23455922 28628118 28205554
CDK4 P53 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 28218424 28628118 28205554
SUV91 DNMT1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 17085482 12711675
UBP4 PPIA â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 29396555 23022198
LMNA RBBP4 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 25948554 19734887
CTBP1 RB â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 28514442 16189514 16713569 33961781 35016035 26186194 11583618
CBX4 RB â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 16189514 11583618 30317550
RB FZR â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 17187060 33971196
RB P53 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 20871633 8083962
RB ZBT16 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 18504436 15949438
RB SIR1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 16892051 17620057
TF3B P53 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 8943363 16189514 16713569
P53 MK14 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 10581258 20213747 17172861 15642743 21675959 21050851
HDAC2 PML â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
E2F3 TFDP1 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
DNMT1 HDAC2 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
JUN PML â—¼   PHYSICAL_INTERACTION 848.0 0.84 STRING 36370105
DGKZ RB â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 16286473
E2F1 SIR1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 19188449 16892051 24112038
ANDR EP300 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 18487222 16713569 27903893 24480624 10779504 32668201 28549433 23172223 34585037 23518348
RB HMGB1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 11748221 16189514
MYC HDAC3 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 23079660 31155734 22002311 18483244
LIN9 RBBP7 â—¼   PHYSICAL_INTERACTION 849.0 0.85 STRING 36370105
TAF1 JUN â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 11316804 16713569
HDAC3 SUV91 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 11788710
RBBP4 SP1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 16713569 12091390 12943729
RB CCND3 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 16782892 17972097 9003773
KDM5A TBP â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 7935440 16713569
ARI4A RB â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 11283269 10490602 21148318 8414517
CEBPB EP300 â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
JUN SP1 â—¼   PHYSICAL_INTERACTION 856.0 0.85 STRING 36370105
E2F1 EP300 â—¼   PHYSICAL_INTERACTION 857.0 0.85 STRING 36370105
BRCA1 CCNA1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16713569 9244350 10373534
KAT2B CCND1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 11328859 10318892
CDK2 CDK13 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 26496610 23602568
CDK2 FZR â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 28514442 33306668 11340163 12560341 23670162 26083744 33961781 23972993
RING1 E2F1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 11583618 27705803
TBP HMGB1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 8006019 9880542 16713569
MYC TBP â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16713569 15723054 8755740
RB ID2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 7926730 11034201
ID2 MYOD1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 21209940 9242638
SIR1 JUN â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 20042607 25609649 23382074 18823944
CDK4 PP1A â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 22939629 17274640
CDK4 CDK13 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 26496610 23602568
SMCA4 PHB â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 12065415 15141164
RB TBP â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 11094070 16713569 9242374
MK14 RB â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 20871633 11566021 17380128 16945434
MAT1 RB â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16189514 11113200
SNPC3 RB â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16189514 11094070
P53 ABL1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 10713716 16713569 10629029
RB ATF2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 11566021 1641004
CDK4 BRCA1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 17334399 16713569 9244350 12509456
SP1 BRCA1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 14710355 16713569 12706836 10720440 17766039
DNM3A CBX5 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 17470536 19834512 12867029
KAT2B E2F1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 24502362 23001041 35140242 19188449 24112038 15123636
MYC EP300 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 15616592 16287840 32140074 16126174 17157259 12776737
RB EP300 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 16878158 11433299 17620057 31753913
ANDR HMGB1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 11748221 9671457 16713569
CTBP1 KAT2B â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 15834423 9824164 16122695
KAT2B MYOD1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 20364308 9659901 27453350 17964260 10944526 10619020 12887892 17468105
TBP MDM2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 9388200 16713569 9271120
MDM4 RB â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 25703327 16510145
MYC CDK6 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 22094256 28628118 28205554
MYC HDAC2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 17314511 20195357 22286234 30415952
MYC UBF1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 21150319 20195357 30415952 29467282
UBF1 TAF1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 16713569 12498690
ANDR TAF1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 20181722 33640491
E2F4 HDAC1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 23060449 9858615 9724731 21102443
HDAC1 UHRF2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 27743347 15361834 21952639 27114453
HDAC1 E4F1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 12730668 21666599
HDAC1 TFDP1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 33961781 27705803
P53 HDAC2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 20388487 22493095 17805299 14976551 21344396 10777477 20190809 17827154
ZBT16 HDAC3 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 24821727 15467736
HDAC3 RBBP4 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 11777905 16189514 11470869
P53 SP1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 14710355 28000777 16740634 9685344 21325822 15710382 15674334 15790310 12665570 19846904 9492043 21831840 11384995 15574328 23650532 16713569 18765668 8463313 20570896
PSD10 CDK4 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 11779854 16189514 11900540 17881001
RB CDC27 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 17187060 7756179
BAG1 RB â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 16189514 12845674
PSD10 RB â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 11900540 30109252 10613832 12525503
MOFA1 RB â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 12397079 11500496
DNM3A RB â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 23280764 11350943
SIR1 SUV91 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 18004385 19218236
MDM2 PML â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
E2F4 LIN9 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
CBX4 CTBP1 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
BRCA1 MYC â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
EP300 MDM2 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
CDK9 MYC â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
CTBP1 BRCA1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 21102443 16713569 10196224 31636387 11751867
EP300 CCND1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 15951563 10567390 11788592
MYC CDK9 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 12944920 19818711 26687678 11673469 17700062 30415952
CCNA1 E2F1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16774918 10022926
E2F1 HDAC1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10734134 9468140 17980157 26468294 9468139
AHR EP300 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10999956 17392787 21988832
SP1 EP300 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 15647279 19062177 10651903 11517158 23714681 10899165 16478997 11030335 24530506 34252870 28425985 31536933 32115405 17623675 10362258 16734381 17906698 22415975 12200149
SIR1 EP300 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 20660480 15632193 19047049
DNM3A MYC â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 15616584 19786833
MYC SIR1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 21807113 22190494
PML HDAC3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16189514 11259576
THOC1 RB â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16189514 7525595
CDK4 CDK6 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 23455922 28205554 28628118 33961781
RB MYOD1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 8381715 11285237
MYOD1 CDK4 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10601020 10022835
DNM3A HDAC1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 11350943 19786833
SMCA4 HDAC2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 19081374 11238380 20596014 16800816 12192000 20460684 14559996
TAL1 HDAC2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16407974 19497860
HDAC2 SP1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 17312152 18059533 16713569 15713621 17894944 12091390 16036112 12151407 21159880 12176973 20697349
SP1 ANDR â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 23369005 9535906 10809237 17984071 15661808
CEBPB CEBPA â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 20102225 1840554 15751966
PRKRA RB â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16189514 9010216
DNMT1 SIR1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 21947282 22094255
AHR TBP â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 8794892 15641800 16713569
CCNA1 GBLP â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16189514 15159402
RB E2F5 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 12502741 16360038 24981860
SUV91 CBX4 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 12101246 22078878
RING1 P53 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 29187402 22907436
LIN9 RB â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 15538385 15479636
P55G RB â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 12588990 16189514
UHRF2 RB â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 21952639 27114453
RB SNPC1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16189514 11094070
UHRF2 P53 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 21952639 22902639
EP300 MYOD1 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
EP300 KAT2B â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
BRCA1 ABL1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17352427 12024016
RBBP4 BRCA1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10220405 16713569 26831064
HDAC2 BRCA1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 21946536 10220405 16713569
HDAC1 BRCA1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 21102443 10220405 16713569
CCND1 BRCA1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17334399 16713569 9244350
ANDR BRCA1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11085509 16713569 11016951
E2F4 BRCA1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 21102443 16713569 9244350
CBX5 RBBP4 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 27705803 24981860 21888893 15306854 15882967 20562864
HDAC3 CCND1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 15713663 12048199 16461912 20484017 15558026
E2F1 CDK2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 8458319 7969176 9199321 1530885 11245432
P53 E2F1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 8557038 11739724 24076372
KAT2B EP300 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 8684459 12888487 9267036 12419806 21413932 22384255 20870727 33051058
KAT2B MYOD1 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
MCM7 MAT1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16189514 11056214
PSD10 MDM2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16023600 17904523 18332869
TAF1 MDM2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 9388200 17237821 16713569
MYC SP1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16713569 11274368 18003922 17418410 15780936 32115405
MYC PML â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17146439 15735755 21150319 32592588 30415952
MYC RB â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28628118 29467282 28205554 30415952 7838535
MYC CDK4 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 22094256 28205554 28628118 21988832
MYC P53 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 21150319 30415952 28628118 28205554
RB PML â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 21205865 16189514 9448006
PML JUN â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 15626733 9671405 16916642 10620019
PML HDAC2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 25812002 18073335 11259576 18644863
HDAC1 MYOD1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11285237 11684023 16713569 20124407
JUN MYOD1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 8380166 1310896 16713569
P53 HDAC1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 19303885 25241761 11313951 10777477 16697957 10521394 19011633 26539911 20075864 12426395 22266186 16107876 17827154 11099047 16959611 20633551 14976551 18765668 32494626
HDAC1 ANDR â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 15640443 11994312 16713569 15835920 26468294 34585037
HDAC1 PHB â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16189514 16713569 12466959 14637159 16964284 17932104 27025967
MO4L1 HDAC2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 20332121 17573780 24981860 14966270 26344197
HDAC2 CTBP1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17967884 31041561 16713569 28947780 16036112 10766745 18212045 11022042
HDAC2 DNMT1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 23708667 17967891 21670149 10888872
HDAC2 RB â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10490602 19293945 11583987 11593423 10228159 17827154 9468139
ANDR HDAC3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 12943985 33640491 16469706
TBP JUN â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 7848298 7685215 16713569 16055710
SP1 JUN â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 25879517 10506225 16713569 33572115 16478997 17215518
RB JUN â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10026157 9545246
SP1 SMCA4 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 15317818 12192045 20969766 11018012
FRK RB â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16189514 7664264
PRKRA P53 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16189514 16713569 9010216
DNM3A DNMT1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 29691401 12145218 21406692
FZR CDC27 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 24100295 20395298 16479161 17187060 20663873 21186364 23670162 23029392 21768287 21986944 11340163 21241890 17942546 32345958 33306668 29700288 25306918 12956947 9811605 23972993 32076268 30498084 23160376 12797865 24811168 12097298 9637688 22014574 9734353 18372912 18662541 17609108 33961781 32152539 26963853
E4F1 RB â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16189514 10869426
LIN9 RBBP4 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17671431 28514442 25917549 17531812 27705803 33961781 24981860
CTBP1 COM1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16287852 10196224 26807646 9535825 31636387
TFDP2 E2F5 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 33961781 26186194
E2F3 RB â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 7739537 31130363 8657117 8246996 8832394 19249677 10779361 17380128 24981860
TF3B RB â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 9169441 10330166 11997511
SMCA4 RB â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 12434308 9128241 19081374 23438604 15485920 10778858 7923370 17666433
PRDM2 RB â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 7538672 9223517
SUV91 RB â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11484059 16189514 11533237
UBP4 RB â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11571651 11571652
ANDR RB â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16964284 16713569 9813067 9675141
TRAP1 RB â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 8756626 9312071
DYR1B RB â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 32707033 23602568
ENC1 RB â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 9566959 16189514 16306221
UBF1 RB â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 7877691 11042686
RB TFDP2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 7739537 16360038 33961781 26186194
RB PAI2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16189514 12944478 16397580
RB TFDP1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 7739537 16360038 17187060 27705803 24981860
RB COM1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 22773103 10779361 17214969 9721205 16581787
ANDR SMCA4 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 18487222 19762545 33640491 28611094 14966121 34585037
HDAC2 SP1 â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
RBBP4 RBBP7 â—¼   PHYSICAL_INTERACTION 891.0 0.89 STRING 36370105
AATF RB â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 10783144 12450794 16189514
ABL1 RB â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 8242749 9071815 7828850 8626527
ABL1 MDM2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16702947 25624478 12110584
MYC ABL1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21400515 23029531 19602047
ABL1 HDAC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 26603102 25219501
JUN ATF2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 8027667 20102225 28514442 16511568 23661758 15546613 26496610 2320002 20195357 10327051 1827203 9445037 20511396 10207054 25609649 33961781
SP1 ATF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 2145272 12760745
SMCA4 BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15034933 16713569 23438604 10943845 26831064
EP300 BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21102443 19887647 10655477 11782371 16713569 21212407 22787115
JUN BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12080089 25609649 16713569
RBBP7 BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11394910 10220405 16713569 11746496
P53 BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 14710355 16713569 21742769 15571721 26140185 9926942 9582019 14636569 14978302 16677609 18501503 9482880 19509300 16969499 31073355
MYC BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12646176 11916966 16713569 20215511 9788437 30415952 14612409
RB BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11521194 10220405 16713569 10518542
CDK2 BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31270457 16713569 10373534 9244350 8764100
BRCA1 PP1A â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 17511879 22990118 12438214 25056273
BRCA1 COM1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 18171670 19369211 17525340 30257991 25184681 21908405 16818604 29656893 26446986 18285836 20351172 25659039 11689934 9738006 10910365 15485915 10764811 25252691 31636387 14578343 29513652 28398198 19452558 10196224 34408138 22231403 17525342 27454289 11739404 16843262 28132842 31932421 24085845 9811458 25310973 26387952 23416467
E2F5 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17106239
DNMT1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19943104 22197621 20631324
E2F2 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17106239
E2F3 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17106239
CBX5 SMCA4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12411497 20011120 15882967 20562864 19498464
E2F1 CBX5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12629508
MYC CBX5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12747840
CCND1 CDK2 â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
ANDR CCND1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15558026 16713569 11328859 16461912 10344732
RB CCND1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15485920 9003781 8867812 9823309 8662825 9139732 11593423 10486249 11126356 12676926 15681588 21242975 31217276 10491434 9190208 8490963 8647086 8449399 21654808 9178893
TAF1 CCND1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9926939 16713569 11126356
CCND1 E2F4 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 11884610 7797074 9144196
CCND1 TFDP2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 11884610 7797074 9144196
CCND1 TFDP1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 11884610 7797074 9144196
CEBPB CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22242598 11162569 12810706
E2F4 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10594784 7929342 9584162
UHRF2 CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21952639
UHRF2 CDK2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21952639 15178429 33876395
CDK2 EP300 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 33961781 26186194 10330164 23455922
CDK2 CEBPA â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11684017 34002296 15107404
CDK2 SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11598016 19450264
CDK2 TFDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12006580 11420722 9315635
CDK9 RB â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12037672 8870681 9258347 8170997
CEBPA E2F1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12869508 11340171 12702500
RB E2F1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 8346196 16249186 12947005 31130363 28542143 15485920 35140242 12502741 17380128 7828850 18391203 1388726 12096339 19058874 15485814 25257171 15619620 9315635 22078878 10207050 8816798 8657117 7958924 29521627 9553123 9219533 18216119 16496386 9422723 10869426 8896460 11839806 15837424 16360038 11470869 9125176 20871633 30867845 12401786 22768064 8626527 15670817 16374512 16766265 28074012 11713253 23472054 11583618 21085491 10499802 11090181 8458319 7739537 9501179 10891495 12963846 9468140 19249677 23001041 9400991 24981860 9632788 8449399 8230483 10393912 19477924 12397079 8255752 12598654
E2F1 PHB â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12065415 10523633 15141164 14637159 14500729
E2F4 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 14576826 10208422
E2F1 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10914734 20837136
E2F1 DNMT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24502362 17575144 15867357
E2F1 CCND3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12611887 16300731
E2F3 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14576826 10766737 18319725
E2F4 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14576826 10766737 18319725
EP300 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10753885 15123636 15126619
SP1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10547281 8657141 10850422
E2F1 MCM7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18328430 18319725 14990995
E2F1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11564866 18319725 90001421
EID1 EP300 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11073990 24167073 11964378 11073989
EP300 MDM2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15154850 20234175 16713569 11070080 9809062 28196907 15013777
EP300 CEBPB â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28428115 9343424 14630807 12471036
EP300 TAL1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11756538 11118214 10490830
EP300 MYOD1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 20364308 12665587 20037778 17964260 35140242 10944526 9862959 9001254 8621548
EP300 P53 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9809062 15295102 21471221 26229107 15337767 23010591 18485870 15558054 22266186 15509808 26625199 9194564 23402884 23870121 17438265 16959611 12690203 17906639 24821727 15664194 21187340 33196849 17977830 11804596 25288747 15186775 18612383 23796514 19234109 27818144 19339993 24157709 9652736 28757384 12499368 17452980 9891054 23880760 31167125 15542844 22013068 16713569 9288740 17189186 11782467 16543236 23329847 10942770 26302407 23307557 22074660 19218448 19217391 10601022 16024799 16782091 12501250 11433299 22731250 23728348 10518217 9194565 25651062 12724314 14612423 16611888 19805293 18243116 32807901 29706626 20234175 16678111 14759370 25867071 25156994 11907332 16438982 16135789 11070080 11359905 25753752 16537920 9744860 18391200 15965232 10490106 16928824 12162806
EP300 JUN â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 27956703 21268080 21937452 24069158 11689449 14630807 11980644 10327051 12437352 12471036 24636898
MDM2 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9809062 11070080 16713569
MYC KAT2B â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15572685 35140242 12660246
KAT2B P53 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19680552 17977830 16678111 15965232 20589832 10891493 12068014 17189186 9891054 10490106 16537920 9744860 12501250 14614455 16959611
KAT2B MDM2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21209460 21060154 32404984 14769800 12068014 28286521
RB MCM7 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12519773 16189514 9705868 16912045 9566894
MYC MCM7 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 17353931 17314511 29467282 30415952
MYC MCM7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
HDAC1 MDM2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15640443 33985974 12426395 30818224
MDM4 MDM2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 10629057 32300648 25512388 21988832 25384516 25809483 17616658 25105592 12874296 31796886 29295817 32075226 20705607 17301054 22493164 25703327 27777309 29523541 27617579 23028042 20473904 22120712 22333590 22902369 22745160 12860999 19432880 21925390 28205554 25659040 19838211 33985974 16055726 25961923 32427989 18566590 22266850 18219319 29057323 10608892 30598450 29524278 25825738 17159902 24813712 31024344 27621617 15604276 29262653 19619542 10218570 28628118 16227609 10827196 12393902 24755078 20724842 34551723 27215386 11606419 20484049 12370303 23671280 26001071 26720344 33961781 12483531 23946421 19683495 26359458
RB MDM2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 25703327 16337594 33185004 20871633 21990374 11433299 16374512 10078201 16510145 15044952 15485814 7791904 9003773
MDM2 PML â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 22869143 16713569 12915590 23169665 14507915 19150978 20972456 15195100 12759344
TAF1 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9388200 17237821 10891494
TAF1 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9388200 17237821 16713569
MDM4 P53 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 10629057 29023092 30672125 31152661 17110929 19521340 10075736 30832340 22807444 12874296 25609649 11528400 24445145 17080083 18677113 20705607 27249653 9226370 17301054 18485870 26148237 27114532 16024788 22374672 24127580 18316739 26876197 29523541 21088494 23028042 24667498 30045945 20515689 25464845 22745160 19432880 21925390 28205554 20174603 21965653 25961923 21075307 22266850 8895579 28487147 32511789 10608892 30598450 25825738 19305137 19255450 11223036 15604276 16713569 28628118 16227609 10827196 12393902 20724842 24659749 12370303 23671280 17875722 33961781 31462704 26186194 23946421 31066983 19075013 15916963 19153082
MYC RAF1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 17314511 9315742 28628118 28205554
MYC SMCA4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11839798 28628118 17353931 29467282 28205554 30415952 14559996
MYC HDAC1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 17314511 18271930 34147029 26496610 30415952 18003922 22286234 24951594
CEBPB MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21098707 20581311 16585579
MYC RBBP4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12747840
MYC HDAC3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC LMNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
CEBPA MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12873812
E2F4 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11564866 12150994 18319725
MYC CEBPA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12873812
MYC SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11274368 16713569
HDAC1 PML â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 16713569 11259576 18644863 25812002 11430826 23563092
ZBT16 PML â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11175338 9294197 16189514
P53 PML â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 25241761 22869143 16713569 12915590 14976551 16007146 20972456 12006491 15375079 11025664 11704853 11080164 21057547
SP1 PML â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9819401 21360626 24728382 16713569
RBBP4 RBBP7 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 17255935 27705803 22863883 33961781 24981860 26186194 15451426 22939629 26344197
RBBP7 RB â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11283269 7503932 2005966 10220405
TAF1 RB â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 7724524 16713569 9858607 11126356 9242374
CEBPA THOC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17242690
CDK6 E2F4 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 11884610 7797074 9144196
CDK6 TFDP1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 11884610 7797074 9144196
CDK6 TFDP2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 11884610 7797074 9144196
SP1 CDK6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12840223 11297539
TFDP2 E2F4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 32296183 10090723 16360038 9501179 33961781 26186194
E2F4 RB â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16360038 9501179 8657117 7958924 9858615 9380698 24981860 12401786 10869426
E2F4 TFDP1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 32296183 16360038 9501179 8657117 7958924 7958925 10540350 27705803 9343408 24981860 9199321 7892279
CDK4 E2F4 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 11884610 7797074 9144196
CCND3 E2F4 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 11884610 7797074 9144196
RB RAF1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 10523633 16189514 9819434 15485920 10486249 21139044 19058874
BAG1 RAF1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11231577 16189514 8692945
PHB RAF1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 10523633 24568222 16189514 16041367 27025967
CTBP1 HDAC1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21102443 9650586 16189514 23752268 31041561 16713569 28947780 10995736 34147029 18765668 11022042
ZBT16 HDAC1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19648967 24821727 16189514 9627120 15467736 16024608 26264872 29997244 32814053 9765306 11865059 23898169
HDAC1 RB â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 10490602 16189514 15003538 11909966 15485920 10888886 11158299 11896613 11583987 10228159 9988677 10778858 11839806 22615382 19081374 12466959 26264872 9491888 10615135 16766265 15044952 17827154 22366686 12473678 10499802 23752268 10891495 9468140 11684023 10958676 21900881 29997244 9724731 10779361 9468139
HDAC1 SP1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15647279 20072153 19062177 11909966 17894944 21636851 18003922 12176973 11896613 15557281 10409740 11517158 15713621 12665570 15722551 17906119 16478997 18850004 16121030 16883603 12091390 15155736 18948152 18059533 16713569 20385359 15528196 16734381 12200149 12847090
HDAC1 CTBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9650586 16713569
ANDR JUN â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9211894 33640491 16713569 8798722
SP1 HMGA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10558886 10471823 11802722
CDK4 CEBPA â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11684017 11867521 15107404
CDK4 RB â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15003538 16189514 30833542 24292678 19556892 15147269 9003781 12949733 8867812 15922743 12509456 16962592 19767775 16985050 9139732 9315635 12519773 10202152 15241418 22094256 10486249 9199321 12676926 15169570 11254678 11900540 10198259 11287611 19225156 16326706 15998794 17873913 16878158 8626527 17015477 17053782 23543736 9190208 12190313 15695403 9464540 8647086 16205633 8756624 8449399 11306463 11971966
CDK4 TFDP2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 11884610 7797074 9144196
CDK4 TFDP1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 11884610 7797074 9144196
PA2G4 ANDR â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9565586 15583694 12165860
PA2G4 RB â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 19946338 11268000
CCND3 TFDP1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 11884610 7797074 9144196
CCND3 TFDP2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 11884610 7797074 9144196
P53 PHB â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 16713569 24380853 14500729 20134482 16319068
RB PHB â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 10523633 16189514 10376528 16964284 24380853
RB DNMT1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 23280764 10888886 11847125
ANC2 CDC27 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 20360068 21768287 22193957 22280307 21043528 27120157 27114510 26811472 16648845 25306918 12956947 26083744 17443186 32076268 22939629 10922056 25043029 16364912 32152539 14657031
KDM5A RB â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 22615382 8414517 7935440 11358960 15949438
E4F1 P53 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 16713569 17110336 12446718 10644996 16652157
TBP P53 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 8395834 16713569 11313951 8083962 10359315 9349482 10601022 12379483 8405994 1465435 7799929
BAG1 ANDR â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 14517289 11278763 9565586 16713569
EID1 RB â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 11073990 15806172 11964378 15044952 11223246 11073989
CCNA1 RB â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 9139732 10022926
LAP2A LMNA â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 22412018 10984438 19727227 16247757 16713569 28902428 24623722 29568061 26496610 34079125 30419336 12475961 16339967 24927568
RB LMNA â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 8058329 16189514 31467278 29997244 8278403 30419336
RBBP4 RB â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11283269 10734134 16189514 11470869 7503932 21689726 8350924
CBX4 CTBP1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 15592428 20098713 33961781 20361981 12679040 26186194 11583618 9858600 12829790
E2F5 TFDP1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 7760804 27705803 24981860 7892279 9464260
CBX4 RING1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21282530 16189514 9858531 22078878 9199346 26496610 27705803 22325352 24981860 30317550
E2F2 RB â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 7739537 16360038 31130363 8657117 8246996 8832394 12502741 17380128 24981860
DYR1A RB â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 32707033 30137413 23602568
TRIPB RB â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 9256431 16713569
MO4L1 RB â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 12397079 11500496
ANDR GBLP â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12958311 32814769 16713569
MAT1 P53 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 30477538 16189514 9372954 16713569
SMCA4 P53 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11950834 19448667 21900401 18303029 17666433
P53 SIR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11672523 18235501 22689577 17964266 22389628 15205477 22735644 12006491 21149449 21245319 18753379 18235502
P53 TFDP1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 8816502 8557038 16189514 16713569
SNPC1 SNPC3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 32296183 16189514 11056176 9003788 33961781 26186194
MOFA1 MO4L1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 32296183 25416956 11500496 16407074 27107012 17353931 17573780 30217970 33961781 26186194 24981860 17008723 22038470 12397079
ANC2 FZR â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 33306668 16287863 12956947 25043029 9811605 26083744 32905768 33961781 21135578 33971196
EP300 HDAC1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
CCND3 CDK2 â—¼   PHYSICAL_INTERACTION 904.0 0.9 STRING 36370105
DNMT1 HDAC1 â—¼   PHYSICAL_INTERACTION 904.0 0.9 STRING 36370105
EP300 JUN â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
EP300 SP1 â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
CCND1 CDK6 â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
RBBP4 SUV91 â—¼   PROTEIN_INTERACTION 0.92 0.92 HIPPIE 16189514 11788710
E2F3 TFDP1 â—¼   PROTEIN_INTERACTION 0.92 0.92 HIPPIE 7739537 31130363 8657117 8832394 27705803 24981860 8755520
HDAC1 SP1 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
E2F2 TFDP1 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
CBX4 RING1 â—¼   PHYSICAL_INTERACTION 926.0 0.92 STRING 36370105
MDM4 MDM2 â—¼   PHYSICAL_INTERACTION ✅ 0.93 0.93 mint 15604276 5217417
MDM4 MDM2 â—¼   COLOCALIZATION ✅ 0.93 0.93 mint 17159902 5219425
CCNA1 CDK2 â—¼   PHYSICAL_INTERACTION 933.0 0.93 STRING 36370105
DNMT1 UHRF2 â—¼   PHYSICAL_INTERACTION 936.0 0.93 STRING 36370105
HDAC2 HDAC1 â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 26949739
MO4L1 HDAC1 â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 28514442 17573780 20332121 26344197
TFDP2 E2F3 â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 28514442 7739537 33961781 8755520 26186194
E2F2 TFDP1 â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 16189514 7739537 31130363 8657117 20211142 8832394 27705803 24981860 8755520
RBBP9 RB â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 16189514 21689726 9697699
CDK2 RB â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 15003538 16189514 17254966 16314512 9139732 9315635 9885575 10207050 15828833 15811853 15241418 10486249 9199321 12970441 12676926 11433299 14681231 9029153 20871633 19225156 16326706 9258347 16878158 10938106 8626527 9190208 21697511 12190313 10499802 12361598 8647086 15173007 8943373 8756624 12800980 11306463 9053846
TFDP1 E2F1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 24981860
RB CDK6 â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 7629134 16878158 24953629 22094256 14627988 10486249 16985050 9199321 10491434 8822197 9885575
HDAC2 SUV91 â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 12711603 11788710
TFDP2 E2F2 â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 28514442 16189514 7739537 33961781 8755520 26186194
CCND3 CDK6 â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
CCND1 CDK2 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 9840943 28514442 8647086 33854235 8479754 26496610 33854239 33961781 23455922 21654808 9178893
E2F1 SP1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 10850422 10409740 8657141 10547281 8657142
ANDR MDM2 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 15640443 32801300 33332287 21157430 18332867 12145204 29755129 28708672 27903893 17974989 29402932 26973243 26196320 23132866 26411689 28151478
HDAC1 SUV91 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 10873456 12711603 11788710
HDAC1 TAL1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 10688671 16407974 19497860
CEBPB RB â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 11596110 8552662 18628207
AHR RB â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 18524851 9712901 11259609 10644764
RB PP1A â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 12434308 16189514 10889204 17008050 17274640 8384581
MK14 ATF2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 10581258 16998585 21444723 12110590 17170118 10708586 12697749 16945434 10085140 11839738 17380123 11279118 7535770 26987986 10978313 9596579 11566021 25098452 16456540 9162092 9753474 9235954 20213747 12118074 26391660 9207092 14499342 31964530 11259586 11532856 18695677
CBX5 SUV91 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 32296183 16189514 25416956 12565857 27705803 32814053 12242305 33961781 24981860 12711603 25931448 20562864
CDK6 CCND1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 15232106 16713569 10022865 24855949 17517622 33854235 11739795 14681455 24953629 11360184 33961781 10580009 17420273 21654808 11160398 9178893 19075005
TFDP2 E2F1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 7739537 9501179 9704927 35140242 9368098 8755520 26186194 33961781
E2F1 TFDP1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 31130363 25368385 20211142 28542143 35140242 9780002 8816798 8657117 9199321 19015639 8816502 16360038 15133492 8405995 30867845 8832394 7892279 7739537 9501179 9704927 27705803 22629304 24981860 9464260
P53 HMGB1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 16189514 16713569 11106654 11748221 9472015 23063560
P53 MDM2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 19303885 25417702 34408321 17268548 23252402 23880345 22807444 15094782 20962272 12529318 21726810 22124327 18981217 16173922 23318437 15558054 22524527 30584071 31626714 22301280 32516735 20174603 22912717 21075307 15848166 18566590 23483203 26882543 23402884 14671306 15001357 10889512 17908790 19411846 10640350 21561866 14499615 33503543 21986495 24998844 15908921 26673821 17098746 25362358 32066565 25739118 29295817 34362424 16595680 20591429 27336364 22745160 24462112 32427887 18467333 26578655 23261415 9271120 16055726 19357310 31591476 23169665 16338390 10608892 30464405 15542844 12612087 22266868 15550400 22331460 22914926 19071110 7686617 14559824 20959462 19941302 14596917 25512388 27129163 19597489 25609649 32904724 11351297 29121928 22487680 11709713 24127580 10562557 15358376 21584881 25312347 27826076 19098711 24980433 24413661 21887275 17116689 14612427 30948704 26001071 19857530 33061576 31138778 23802716 20234175 25313037 21988832 17616658 11744695 17666403 22525275 12897156 25156994 33020477 11925449 16152627 29876924 30244831 1614537 17363365 22474335 11112690 23443559 17297477 27905468 19085961 20479273 31940492 21261729 14517261 26908445 16866370 27893708 22653443 17470788 10488081 23370271 19223463 16751805 26556313 10734067 19411066 11223036 27856536 14704432 20124408 24240685 24842904 32901886 22948151 19234109 35140242 21084285 32894144 17848574 22737255 10561590 25168242 10435614 11697899 25543083 21572037 22920093 18604177 32874188 22659184 17591690 16845383 22444248 31239268 25283148 26186194 24200963 23826318 7689721 20047188 24314634 12167711 15308643 17318220 21857681 11431470 18815136 15950904 20705607 17525743 26876197 31177307 9529249 22374672 12915590 33650658 10601022 20837658 18223694 30097011 28205554 32334023 15247280 23776465 21268072 27308622 11713288 18234963 9582019 18784078 29487367 23776060 11713287 20484049 26720344 9131587 30109812 33961781 24361594 32807901 31066983 15824742 11562347 21454483 22157679 21088494 11070080 22575647 22083959 26540344 15210108 18332869 32528731 18172499 11094089 21132010 16414131 10827196 27031960 10892746 15280377 16023600 18665269 10202144 15058298 29549180 16212962 16905769 11278372 20657550 9809062 15295102 26238070 22391559 18061646 17310983 18485870 9278461 21925390 20659896 9824166 23150668 25637791 30598450 19160491 28605833 12690203 22467867 31594538 11572869 11384992 11486026 27807478 17936559 30679555 16678796 30252118 31652301 15144954 22411991 22084066 30175854 21478269 27543608 16624812 17290220 32097779 17301054 20694676 11714701 24667498 20395212 16547496 12381304 8058315 22266850 29755129 22085928 17159902 10196247 21316347 27886165 27215386 25384516 7926727 16964247 19081178 32198344 11046142 28549433 26350565 31533005 12867035 10321734 19590512 22991965 25277184 24207125 18541670 19166840 25103245 30320919 26883110 20235143 17139261 11597128 21071676 19568783 18813780 19805293 17056014 17989425 21317885 17234751 20588255 21170087 10347217 11839577 25954860 21060154 24926618 21750659 16331255 29269425 27811966 19305137 24659749 9450543 23201157 30879903 16870621 28362432 21149449 20570896 23609977 33765973 27106262 33355139 34040386 22588298 22389628 19033382 18264029 27462439 31092600 12208736 17369817 28082682 16579792 23246961 20708156 15013777 21465263 28542145 23572512 19483087 31665549 22975381 17438265 15604276 11178989 24488098 16432196 22227409 28628118 30005830 20639885 20847049 9363941 31406141 19816404 26475964 29899406 16861890 30320499 20660730 19332559 14702041 11284721 18316739 19837670 25464845 12426395 10681559 17302414 16107876 22510990 15154850 21098709 19106616 10722742 19188367 22366412 29524278 21084564 23134341 25624478 30455251 20173098 12620407 9223638 16713569 17426254 31647545 10766163 30454706 21471462 24621507 23652204 19153082 8875929 31152661 18309296 31968249 31796886 15122315 30532073 10980696 17080083 15064742 11285227 29547122 21965653 33495326 23728348 15242646 17347673 12842086 12944468 19255450 23671280 22916255 17875722 30355102 14741215 23946421 20591651 15053879 28514442 25241761 24567357 16215989 19656744 30832340 22262183 27249653 26203195 16857591 15313915 15933712 28223335 20542919 12552135 24643130 27282385 20080206 28553961 22819825 33579943 16159876 9724739 17380154 22318540 29997244 29670376 22103682 22032989 28394340 31903119
HDAC2 RBBP7 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 22939629 20388487 27705803 21258344 33961781 24981860 26186194 15451426 12493763 9885572 26344197
RBBP7 HDAC1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 19703393 10444591 21258344 11102443 9885572 17255935 10471499 26496610 25885317 22939629 9150135 23752268 9790534 27705803 33961781 26186194 19686092 15451426 12920132 26344197
CDK6 CCND3 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 8153045 21516116
CDK6 CCND3 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 16189514 25416956 33854235 14681455 21516116 32296183 17517622 9716181 11360184 30217970 23602568 15232106 26264872 27107012 32707033 16782892 16713569 8114739 29997244 32814053 33961781 26186194
HDAC2 HDAC1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 25241761 9520398 11287668 19703393 30737378 17894944 10444591 11466315 11777905 21258344 15297431 17956988 11102443 9885572 12032298 19041848 26496610 22416134 12493763 11739383 10581039 11804585 11564889 21670149 22939629 9150135 11919195 23752268 18059533 16713569 9804427 20388487 9790534 26949739 24981860 33961781 15987735 19182791 15451426 12920132 26344197
RBBP4 HDAC1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 16189514 9520398 19703393 31435636 9150133 10444591 21258344 12943729 11102443 9885572 27068747 10471499 26496610 34518534 20127688 11171972 10734134 11470869 20585571 10220385 12091390 17643391 21670149 11602581 17827154 22939629 9150135 23752268 16713569 9790534 27705803 19686092 24981860 33961781 11302704 11118440 15451426 12920132 26344197
HDAC1 DNMT1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 22274925 20613874 26794444 10615135 10888886 17707923 17934516 15870198 21670149 27593931 17967891 12473678 23708667
HDAC2 RBBP4 â—¼   PHYSICAL_INTERACTION 969.0 0.97 STRING 36370105
TF3B TBP â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 16713569 7624363 30413534 10921893 11809839 26496610 18391023
LIN9 RBBP4 â—¼   PHYSICAL_INTERACTION 969.0 0.97 STRING 36370105
HDAC2 RBBP7 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
HDAC1 RBBP7 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
CDK4 CCND3 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 8153045 21516116
ATF2 JUN â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
E2F5 TFDP1 â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
E2F1 TFDP1 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
CCND1 CDK4 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 28514442 25416956 25241761 8259215 9372967 29142209 9150368 18537972 16431923 33854235 24292678 9178893 33854239 9106657 14681455 8867812 8662825 17420273 19767775 16985050 19075005 12519773 21306487 26203195 24855949 23007395 11360184 10580009 11463845 17081987 8978686 16613857 15681588 21242975 15232106 9837900 24218572 27130439 10022865 25910212 9228064 12036906 23707388 23543736 27107012 23718855 19470470 31217276 10908655 8756624 25502805 17205132 33961781 20837141 19237565 21654808 11160398 7568034
E2F4 TFDP1 â—¼   PHYSICAL_INTERACTION 989.0 0.99 STRING 36370105
HDAC2 RBBP4 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 31435636 21258344 12943729 9885572 34518534 12493763 12091390 21670149 17827154 22939629 16713569 9804427 20388487 27705803 33961781 24981860 11302704 15451426 26344197
CCND3 CDK4 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 28514442 16189514 25416956 21988832 33854235 9106657 14681455 21516116 23880157 16985050 32296183 10342870 26496610 19237555 9716181 11360184 30217970 15232106 14641107 25910212 27107012 16782892 33961781 26186194 11896535
CCND3 CDK4 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
HDAC1 RBBP4 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CCND1 CDK4 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
MDM2 MDM4 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
BRCA1 ABL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 12919958 12024016 17352427
ABL1 CEBPB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19563810
ABL1 MDM4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 20651945 29262653 26148237 19075013 20841568 28690977 29348869
ABL1 MYOD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 12415271 21212806 26998525 20841568
ABL1 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 19818398 18619508 10637231 20841568 14757045 15302935
ABL1 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 32.0 1.0 Omnipath 23331499 12110584 20651945 29065514 22352870 16702947 25973395 27626309 21081495 27956626 20841568 14757045 19738896 15212693 28690977
ATF2 RAF1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 11274345 12738796 18039929 20506250
ATF2 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 9990041 10915780 11850817 11410592 11739785 15691880 16405968 10464245 10500157 15314161 10066798
ATF2 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 10366004 10327051 8530413 12052888 15068801 12751796 9502786 9141200 9252389 11238729 12903123 19255142 11736649 16511568 9819389
ATF2 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 25609649 20102225 15546613 2320002 10327051 1827203 9445037 26496610 20195357 16511568 20511396 10207054 8027667 23661758 31515488 18641343 1828107
BRCA1 E2F1 â—¼   PHYSICAL_INTERACTION 24.0 1.0 ACSN 10884389 11877377 12496474 15175241 15220350 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 18660752 19525936 19793801 20029420 20376879 21060331 21337561 24254977 7575488 7935440
BRCA1 E2F1 â—¼   SHARES_COMPLEX 24.0 1.0 ACSN 10884389 11877377 12496474 15175241 15220350 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 18660752 19525936 19793801 20029420 20376879 21060331 21337561 24254977 7575488 7935440
BRCA1 E2F1 â—¼   ENZYMATIC_REACTION ✅ 24.0 1.0 ACSN 10884389 11877377 12496474 15175241 15220350 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 18660752 19525936 19793801 20029420 20376879 21060331 21337561 24254977 7575488 7935440
E2F4 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 20133863 21701264 17531812 17001309 20818429 17106239 23108140
SP1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15252835 17373631 18377656 19466541
CTBP1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20818429 21681822 23303449
E2F1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 10660629 23285190 18660752 19466541 17106239 20068145 23108140
MYC BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12032322 19882681 20940401 10375022 21668996 11916966 12646176 11983916
E2F4 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9244350 18319725 16713569 12909625
E2F1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9244350 18660752 18319725 11278247 12697828 16713569 12909625
CDK2 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 8764100 10373534 10550055 19683496 16713569 26719576 15212693
CDK4 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 9244350 16713569 17334399 20932174
E2F4 CBX5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17531812 11799066
TAF1 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15870300 10086334 22711989 12569092 15893730
SP1 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 10497251 22911796 19850937 9236224 17617380 9407106 15870300 22415074 10850422 9584162 10908361 22734486 16267018 9637785 19755513 11410592 11024050 15922873 12794082 20435036 22334592
MYC CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 7526316 21933022 17881732 12835716 14757441 19086036 8552398 19698176 19786833 18809243 18806825 8196642 11085504
JUN CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 39.0 1.0 Omnipath 16393119 21135252 8917510 17166846 19622016 11402335 20220142 22853846 17670745 10567390 17496887 19499154 9878062 21474819 17278098 15282324 15467760 15994313 14672732 15574422 22550166 10066798 17637753 20482821 15574764 11745411 11410592 18084253 20037604 12794082 10790372 16860316 24190040 17501623 17477349 19435822 10500157 11432833
ID2 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19587095 21194482 22835384 12527902 17559421
E2F1 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 10504464 7929342 22768064 19876926 20220142 9584162 17998543 20655656 8618861 8137237 23078099 23543735 10594784
EP300 CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 17306568 17666529 11788592 23343194 21285352 15576399 21151179 22761862 22290435 16039586 19619488 19623618 17143292
CTBP1 CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 17666529 23343194 21285352 18974774 22761862 22290435 16039586 19619488 19623618 17143292
HDAC2 CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 21734722 17666529 15576399 22761862 22290435 19923891 20682799 15713663
JUN CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 18813803 19219074 16406505 16880536 16054035 19190345 17000779 17439715 8545107 16396903 11274345 20107231
MYC CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 8425218 15121849 2006410 17873522 21406394 12584560 17558397 20551172 15814658 16908182
CCND1 CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 63.0 1.0 Omnipath 26203195 17145710 8978686 12036906 23562856 25416956 16985050 23707388 19767775 9837900 17517622 19237565 9372967 25502805 23718855 9228064 7736585 15232106 11360184 20837141 21306487 25910212 25241761 27107012 9150368 18537972 9178893 31217276 8867812 10580009 23007395 11160398 19470470 19075005 9106657 8259215 10908655 8756624 23543736 24855949 7568034 24218572 8662825 31515488 17205132
CCND1 TFDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 9190208 10498883 9315635 10385618 10778858 9736735 7736585 9425340 11520855
CCND1 CDK6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 19075005 17517622 9178893 11739795 24855949 15232106 16713569 11360184 10580009 11160398
CCND1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 9190208 10498883 18590585 7575488 9315635 17303408 10385618 10778858 9736735 16236519 20068082 7736585 9425340 11520855 19075565 18786381 17660363 15279786
MYC CDK2 â—¼   PHYSICAL_INTERACTION 34.0 1.0 ACSN 11274345 11283614 12545156 14536078 15147722 15155580 15279786 17055429 17303408 17550342 17558397 17660363 17873522 18590585 18636226 19887899 20027199 20237412 20551172 20581311 20713526 20818389 21406394 21733352 2191300 21919891 22067385 23140366 23869868 24954210 25002027 28536364 7575488 9618481
CCNA1 CDK2 â—¼   PROTEIN_INTERACTION 1.0 1.0 HIPPIE 16189514 15583032 25241761 16777603 10559988 14681455 9636170 16159883 9041194 10652300 8565853 12970441 14701826 8397206 14681231 11264176 8397207 15601848 12191604 12190313 7799941 19423708 12800980 16009130
MYC CDK2 â—¼   SHARES_COMPLEX 34.0 1.0 ACSN 11274345 11283614 12545156 14536078 15147722 15155580 15279786 17055429 17303408 17550342 17558397 17660363 17873522 18590585 18636226 19887899 20027199 20237412 20551172 20581311 20713526 20818389 21406394 21733352 2191300 21919891 22067385 23140366 23869868 24954210 25002027 28536364 7575488 9618481
CDK2 E2F1 â—¼   ENZYMATIC_REACTION ✅ 27.0 1.0 ACSN 12086603 14536078 14988723 15136767 15147722 15175241 15279786 15798197 16713580 16805667 17102137 17116885 17296725 17303408 17384638 17582221 17660363 18469862 18590585 18636226 18995830 19282663 19342888 19622404 19793801 20051983 7575488
CDK2 MCM7 â—¼   ENZYMATIC_REACTION ✅ 18.0 1.0 ACSN 14536078 15147722 15175241 15279786 15677884 16581787 17038621 17102137 17116885 17296725 17303408 17582221 17660363 17713585 18590585 18636226 19793801 7575488
E2F4 CDK2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17531812 22447046
CDK2 UHRF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17145710 33876395 21952639 15178429
CDK2 DNMT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21565170
CDK2 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 8386367 27653698 17081983 19966300 18669648 29896817 17570479 20713526 17558397 15103331 22348395 20445224
CDK2 CEBPB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 17601773 22369944 17570479 20818427
CDK2 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 7575488 18590585 9315635 17303408 17570479 25101673 16213134 17660363 12006580 11420722 15279786
CDK2 MYOD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 21902831 10942602 25751651 25552934 22179841 17570479 10082583 26825227 10764802 9710583
CDK2 ID2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 28122577 9029153 14733935 26110849
E2F1 MCM7 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 15279786 17218262 17303408 17660363 18328430 18590585 7575488
SP1 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9054613 12697671 10446910 18440323
E2F3 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14576826 7958836 12063292
E2F1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 8208548 2721961 7753559 11705881 24038073 8355712 1549358 1567856 12629508
TFDP2 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 26186194 9704927 9368098 8755520 9501179 7739537
CDK6 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 9190208 10498883 18590585 7575488 9315635 17303408 10385618 10778858 9736735 16236519 20068082 7736585 9425340 11520855 19075565 18786381 17660363 15279786
CCND3 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 9190208 10498883 18590585 7575488 9315635 17303408 10385618 10778858 9736735 16236519 20068082 7736585 9425340 11520855 19075565 18786381 17660363 15279786
CDK4 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 9190208 10498883 18590585 7575488 9315635 17303408 10385618 10778858 9736735 16236519 20068082 7736585 9425340 11520855 19075565 18786381 17660363 15279786
CCNA1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 17660363 15840440 16135794 18590585 7575488 17303408 9736735 15133492 15558010 15123636 9556498 10022926 16213134 11980909 16123593 11739724 15279786
E2F1 TFDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 20211142 15133492 22327218 7892279 16360038 9199321 8405995 9704927 8816798 9780002 8657117 9464260 22629304 7739537 27705803 25368385 9501179 8816502 8832394
KAT2B EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8684459 14500836 9267036 17496784 20870727
EID1 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11073989 11073990
EP300 MYOD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10944526 9001254
EP300 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 17145710 22290435 19623618 11804596 23343194 22761862 16039586 12776737 17157259 17143292 12660246 15576399 21151179 15522869 17306568 19407812 17666529 21285352 19619488
SP1 KAT2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20130956 20144149 17882273 15647279
KAT2B MYOD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17145710 9659901 10944526 10619020
E2F4 MCM7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17531812 14990995
HDAC3 MDM2 â—¼   PHYSICAL_INTERACTION 51.0 1.0 ACSN 10721693 11283614 11715018 11779693 11923280 12545156 12668723 14761977 15024084 15140942 15151915 15155580 15169778 15465827 15574337 15876864 16232121 17055429 17110379 17158541 17508028 17550342 17823410 19448627 19459846 20027199 20066118 20182602 20457558 20506250 20679392 20713526 20818389 21234400 21336307 21340684 21483453 21518799 21733352 21764762 2191300 21919891 22102694 22370643 22754780 22796940 23140366 23869868 6396087 9450543 9618481
HDAC1 MDM2 â—¼   PHYSICAL_INTERACTION 51.0 1.0 ACSN 10721693 11283614 11715018 11779693 11923280 12545156 12668723 14761977 15024084 15140942 15151915 15155580 15169778 15465827 15574337 15876864 16232121 17055429 17110379 17158541 17508028 17550342 17823410 19448627 19459846 20027199 20066118 20182602 20457558 20506250 20679392 20713526 20818389 21234400 21336307 21340684 21483453 21518799 21733352 21764762 2191300 21919891 22102694 22370643 22754780 22796940 23140366 23869868 6396087 9450543 9618481
HDAC1 MDM2 â—¼   SHARES_COMPLEX 51.0 1.0 ACSN 10721693 11283614 11715018 11779693 11923280 12545156 12668723 14761977 15024084 15140942 15151915 15155580 15169778 15465827 15574337 15876864 16232121 17055429 17110379 17158541 17508028 17550342 17823410 19448627 19459846 20027199 20066118 20182602 20457558 20506250 20679392 20713526 20818389 21234400 21336307 21340684 21483453 21518799 21733352 21764762 2191300 21919891 22102694 22370643 22754780 22796940 23140366 23869868 6396087 9450543 9618481
HDAC3 MDM2 â—¼   SHARES_COMPLEX 51.0 1.0 ACSN 10721693 11283614 11715018 11779693 11923280 12545156 12668723 14761977 15024084 15140942 15151915 15155580 15169778 15465827 15574337 15876864 16232121 17055429 17110379 17158541 17508028 17550342 17823410 19448627 19459846 20027199 20066118 20182602 20457558 20506250 20679392 20713526 20818389 21234400 21336307 21340684 21483453 21518799 21733352 21764762 2191300 21919891 22102694 22370643 22754780 22796940 23140366 23869868 6396087 9450543 9618481
HDAC1 MDM2 â—¼   DOWN_REGULATES ✅ - 51.0 1.0 ACSN 10721693 11283614 11715018 11779693 11923280 12545156 12668723 14761977 15024084 15140942 15151915 15155580 15169778 15465827 15574337 15876864 16232121 17055429 17110379 17158541 17508028 17550342 17823410 19448627 19459846 20027199 20066118 20182602 20457558 20506250 20679392 20713526 20818389 21234400 21336307 21340684 21483453 21518799 21733352 21764762 2191300 21919891 22102694 22370643 22754780 22796940 23140366 23869868 6396087 9450543 9618481
HDAC3 MDM2 â—¼   DOWN_REGULATES ✅ - 51.0 1.0 ACSN 10721693 11283614 11715018 11779693 11923280 12545156 12668723 14761977 15024084 15140942 15151915 15155580 15169778 15465827 15574337 15876864 16232121 17055429 17110379 17158541 17508028 17550342 17823410 19448627 19459846 20027199 20066118 20182602 20457558 20506250 20679392 20713526 20818389 21234400 21336307 21340684 21483453 21518799 21733352 21764762 2191300 21919891 22102694 22370643 22754780 22796940 23140366 23869868 6396087 9450543 9618481
MYC MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15655352 12695333 19649205 10348347
MDM2 MDM4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 69.0 1.0 Omnipath 17145710 10218570 17616658 16511560 22266850 12874296 21925390 25825738 21988832 25512388 16227609 22493164 22902369 25659040 18219319 12963717 15604276 18566590 12370303 19838211 26359458 27617579 25809483 34551723 10608892 23028042 22120712 25703327 12860999 32300648 16055726 24813712 17301054 12483531 23671280 17159902 27621617 25105592 20484049 20724842 27215386 10827196 26001071 11606419 23946421 19683495 20705607 24755078 25384516 20473904 12393902
MDM2 PML â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15195100 12759344 14507915 16713569 12915590
JUN MYC â—¼   ENZYMATIC_REACTION ✅ 40.0 1.0 ACSN 11274345 11929833 11955436 11967263 12051714 15001769 15576399 15768032 15806138 16007074 16039586 16169192 16510874 17050667 17143292 17291450 17439715 17936032 18347071 18627596 19619488 19623618 20006983 20122174 20530697 20705860 20920541 21285352 21767405 22290435 22705350 22761862 23306204 23343194 24023259 25730849 26587781 7542250 8545107 8666229
JUN MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 21835891 8276360 1774959 2498162 21607323 20410304 14523011 18037408
E2F4 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 24573694 17132729 17699159 11689553 12757710
TBP MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20886042 7880838 9797456 15876353 14506152
SP1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11470523 9492315 2284094 8437848 7753559 8355712 2057364
MYC CEBPA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 15681429 17082780 7556187 8076602 20097210 12695333 15867211 19259613
MYC ID2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12447693 12695333 12824180 18437010 18483244 12545167
MYC MYOD1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 1850105 7970710 19723804 12101422
MYC CDK4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 15208653 12835716 24951594 21384303 14519204 22395148 10688915 17728244 11983916 18414489
MYC CDK6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20682794 22395148 12835716
JUN MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 29.0 1.0 Omnipath 15806138 16510874 22290435 18627596 19623618 11929833 23343194 15768032 22761862 17050667 16039586 20122174 17291450 20920541 17143292 20006983 17439715 15576399 21767405 23306204 8545107 22705350 18347071 16007074 16169192 21285352 20530697 19619488 11274345
HDAC1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 21734722 17666529 15576399 22761862 22290435 19923891 20682799
MYC CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21988832 11602341 17093053 22094256
TAF1 TBP â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
TBP TAF1 â—¼   PROTEIN_INTERACTION 1.0 1.0 HIPPIE 29111974 17375202 31753913 7680771 17967894 9311784 9858607 9674425 9153318 15870300 8995708 7597030 15564746 9603525 18391197 9660973 16713569 8858156 17884155 19240132
TAF1 TBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16858867 11316804 9699517 15808844
CCND3 CDK6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 17517622 8114739 26186194 27107012 23602568 10477583 16782892 21516116 25416956 29997244 31515488 32814053 15232106 32296183 11360184 16713569 9716181
CDK6 TFDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 9190208 10498883 9315635 10385618 10778858 9736735 7736585 9425340 11520855
ID2 MYOD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 9242638 8380166 21209940 1922066
JUN MYOD1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 2167198 19723510 1313772 8120060 8264634 1310896
MYOD1 SP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10082523 1662816 9148896
HDAC1 MYOD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16713569 20124407 11684023 11285237
CDK4 MYOD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 21902831 10022835 10601020
E2F4 E2F2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17531812 21247883 9149906 15718499
JUN RAF1 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 11274345 12738796 17439715 18039929 26587781 8545107
HDAC1 HDAC2 â—¼   PHYSICAL_INTERACTION 28.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21685935 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC1 HDAC3 â—¼   PHYSICAL_INTERACTION 22.0 1.0 ACSN 11283614 12545156 12668723 15151915 15155580 15465827 16232121 17055429 17508028 17550342 20027199 20713526 20818389 21234400 21733352 2191300 21919891 22370643 22796940 23140366 23869868 9618481
HDAC1 HDAC2 â—¼   SHARES_COMPLEX 28.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21685935 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC1 HDAC3 â—¼   SHARES_COMPLEX 22.0 1.0 ACSN 11283614 12545156 12668723 15151915 15155580 15465827 16232121 17055429 17508028 17550342 20027199 20713526 20818389 21234400 21733352 2191300 21919891 22370643 22796940 23140366 23869868 9618481
HDAC1 HDAC2 â—¼   UP_REGULATES ✅ + 28.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21685935 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC1 HDAC3 â—¼   UP_REGULATES ✅ + 22.0 1.0 ACSN 11283614 12545156 12668723 15151915 15155580 15465827 16232121 17055429 17508028 17550342 20027199 20713526 20818389 21234400 21733352 2191300 21919891 22370643 22796940 23140366 23869868 9618481
HDAC3 HDAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11302704 16189514 23213415 10944117
HDAC3 HDAC2 â—¼   PHYSICAL_INTERACTION 28.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21685935 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC3 HDAC2 â—¼   SHARES_COMPLEX 28.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21685935 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC3 HDAC2 â—¼   UP_REGULATES ✅ + 28.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21685935 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
SP1 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 20148354 8355696 8892460 1406636 19437621 9054614 17502875
JUN CCND3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 18813803 19219074 16406505 16880536 16054035 19190345 17000779 17439715 8545107 16396903 11274345 20107231
SP1 CCNA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15922873 10196209
SP1 AHR â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 9778040 16410262 21569840 20478378
CCND3 CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 43.0 1.0 Omnipath 11896535 25416956 16985050 34591612 21988832 14597415 17517622 16782892 10342870 21516116 23880157 15232106 16189514 11360184 26496610 25910212 26186194 27107012 10477583 19237555 32296183 14641107 9106657 9508775 31515488 9716181
CDK4 TFDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 9190208 10498883 9315635 10385618 10778858 9736735 7736585 9425340 11520855
CEBPB CEBPA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 9990015 19581927 10603305 15509789 16431920 19663997 15110775 7862113 10854425 17301242 24216764 20179325 15158467 17646392 18622014
CCND3 TFDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 9190208 10498883 9315635 10385618 10778858 9736735 7736585 9425340 11520855
E2F3 TFDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8755520 7739537 8657117 8832394
TFDP2 E2F2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8755520 7739537 16189514
E2F2 TFDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 20211142 8657117 8755520 16189514 7739537 8832394