Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
MDM2 ATM â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 19816404 21986495
SP1 ATM â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15837784 11466608
FOXO3 ATM â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18344987 18424439
ATM SMC1A â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 11877377 5215162
CCNG1 PPP2R1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219546 17245430
CCT3 STAT3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 24756126 1001844
CCT8 CCT6A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
PPP2R1A FOXO3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20110348 8288835
FOXO3 AKT1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 10102273 5211323
PPP4C FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16530049 23331499
FOXO3 NOS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16100571
IER3 PPP2CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16456541 5218298
SP1 IER3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11844788
MAP2K3 MAPK14 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8622669 7535770
MAPK14 MAPT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20626350 15632108
MAPT AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0709180105 18292230
GSK3B MAPT â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 17078951 5219283
MDM2 ARRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5214648 11588219
ARRB2 MDM2 â—¼   UBIQUITINATION ✅ 2.0 0.8 intact 5214648 11588219
SMC1A RAE1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18832153 0807660105
TERT AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18775701 6742757
PTEN CAV1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12176037 6731969
EZH2 PTEN â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 24719098 22956625
CAV1 PTEN â—¼   COLOCALIZATION 2.0 0.8 intact 12176037 6731969
PTEN SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12804776
RACGAP1 AURKB â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 18201571 6166552
NOS3 CAV1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17502619 0611416104
SP1 KISS1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20375015 20152817
SP1 CCNE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16516150 15818598
SP1 PRKCB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12105191 20179320
SP1 HDAC4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16280357
PPP2CA SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24382322
TUBA1A HDAC6 â—¼   DEACETYLATION ✅ 2.0 0.8 intact 5215415 12024216
PPP2CA HDAC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18045992
STK26 PPP2R1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8213804 18782753
STK26 PPP2CA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8213804 18782753
PPP2CA RACGAP1 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 intact 18201571 6166552
PPP2CA CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10644691 19061640
PPP2CA EIF4EBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16899564 16109716
GSK3B CTNNB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219694 17318191
SP3 CYP17A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11463853
PPP2CA PPP4C â—¼   PHYSICAL_INTERACTION 807.0 0.8 STRING 36370105
AKT1 MDM2 â—¼   PHOSPHORYLATION ✅ 0.81 0.81 mint 5217292 15527798
MDM2 AKT1 â—¼   PHOSPHORYLATION ✅ 0.81 0.81 mint 5217292 15527798
SP3 SP1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 15247906 11517158 10825178 16734381 9329821 12414801 12200149 23825960
GSK3B CCNE1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 25241761 14536078 8861947
PPP2R1A PPP2R3A â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
AKT1 GSK3B â—¼   DOWN_REGULATES ✅ - 0.82 0.82 Signor 15829723
AKT1 GSK3B â—¼   PHOSPHORYLATION ✅ - 0.82 0.82 Signor 23552696
MAPT MARK2 â—¼   PHYSICAL_INTERACTION 829.0 0.83 STRING 36370105
SGOL1 SET â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 26496610 16541025
AKT1 MAPK14 â—¼   PHYSICAL_INTERACTION 830.0 0.83 STRING 36370105
MDM2 NPM1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
CAV1 NOS3 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
UBE4B MDM2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 24587254 21317885
SP1 STAT3 â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
PPP4C PPP2R1A â—¼   PHYSICAL_INTERACTION ✅ 0.84 0.84 mint 27880917
FOXO3 MDM2 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
GSK3B CTNNB1 â—¼   PHOSPHORYLATION ✅ - 0.84 0.84 Signor 16293724
CCNG1 MDM2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 12556559
STAT3 STAT1 â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 6730629 8662591
SP1 STAT3 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 17471507 24396070 21184768 16931573
TEP1 TERT â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 16713569 9837921 11029039 9389643
AKT1 PTEN â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
CCT7 IGBP1 â—¼   PHYSICAL_INTERACTION 855.0 0.85 STRING 36370105
AKT1 PTEN â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 12297295 19903340 12077256 28628118 20605778 28205554 10866658 20596030
AKT1 NOS3 â—¼   PHOSPHORYLATION ✅ + 0.86 0.86 Signor 24379783
HDAC6 CYLD â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 19893491 20593489
SP1 SP3 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
PPP2R1A PPP2R4 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
AKT1 FOXO3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 21621563 10102273 25241761 21775285
CAV1 NOS3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 8910295 12852865 11425855 17502619
AKT1 NOS3 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
STAT1 STAT3 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
ARRB2 MDM2 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
ATM H2AFX â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
HDAC6 TUBA1A â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
AKT1 PPP2CA â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
ATM SMC1A â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11877377 11877376
AKT1 TERT â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28628118 15843522 28205554 10224060 18775701
FOXO3 ATM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18344987
ATM AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15546863 15899889
MAPK14 F3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 23195225
AKT1 MDM2 â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
MDM2 ARRB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 17984062 15878855 32450252 26545496 12488444 11588219 21988832 21466165 33649538 21389118 18544533 21081496 32828283 12538596
GSK3B MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16055726 18505846
PPP2CA MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11983168
STAT3 CCNE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22583478 19049964 19010822
STAT3 CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20830236
TERT CTNNB1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 19571879 11532957 21654818
AURKB HDAC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 22865920
SP3 SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9329821 15247906 10825178
SP1 NOS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 7541039
SP1 HDAC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18632985 18850004
AKT1 GSK3B â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19713527 8524413 23824745 16009706 29464284 20856200 19995607 16123141 20682768 27563096 14645548 15688030 22337773 11035810 17428466 18505846 15470047 14701753 16282323
TUBA1A GSK3B â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
SET PPP2CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9353299 21806989
EIF4EBP1 GSK3B â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
IGBP1 MID1 â—¼   PHYSICAL_INTERACTION 905.0 0.9 STRING 36370105
IGBP1 PPP4C â—¼   PHYSICAL_INTERACTION 0.9 0.9 HuRI 32296183
MST4 PPP2R4 â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
AKT1 ARRB2 â—¼   PROTEIN_INTERACTION 0.92 0.92 HIPPIE 18191226 19122674 19262695
PPP2R1A PPP4C â—¼   PHYSICAL_INTERACTION 926.0 0.92 STRING 36370105
MAP2K3 MAPK14 â—¼   PHYSICAL_INTERACTION 928.0 0.92 STRING 36370105
AKT1 GSK3B â—¼   PHYSICAL_INTERACTION 934.0 0.93 STRING 36370105
AKT1 FOXO3 â—¼   PHYSICAL_INTERACTION 939.0 0.94 STRING 36370105
PPP4C IGBP1 â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 27880917
PPP2CA IGBP1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 8434208 23892082
PPP2CA SGOL1 â—¼   PHYSICAL_INTERACTION 953.0 0.95 STRING 36370105
AKT1 MDM2 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 32450252 25241761 18332867 12145204 19166854 15527798 20856200 11715018 23397142 11504915 11923280 21930127
PPP2CA PPP2R4 â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
CTNNB1 GSK3B â—¼   PHYSICAL_INTERACTION 969.0 0.97 STRING 36370105
MAPT PPP2CA â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
STAT1 STAT3 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 16007122 11722592 16189514 25241761 28514442 26966684 8662591 11594781 31462771 35140242 33961781 25609649 12070153
CCT8 PPP2CA â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
CCT2 PPP2CA â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
CCT3 PPP2CA â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
CCT4 PPP2CA â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
CCT5 PPP2CA â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
CCT6A PPP2CA â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
CCT7 PPP2CA â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
PPP2CA TCP1 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
MST4 PPP2R1A â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
CCT2 CCT6A â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CCT3 CCT6A â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CCT4 CCT6A â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CCT6A TCP1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CCT6A CCT7 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CCT6A CCT8 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
MST4 PPP2CA â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GSK3B MAPT â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
CCT4 CCT8 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
CCT5 CCT6A â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
CCT2 CCT8 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT2 CCT3 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT3 CCT4 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT3 TCP1 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT3 CCT7 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT4 CCT5 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT4 CCT7 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT7 CCT8 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT8 TCP1 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CCT2 CCT7 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT2 TCP1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT2 CCT4 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT2 CCT5 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT3 CCT5 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT3 CCT8 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT4 TCP1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT5 TCP1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT5 CCT8 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT5 CCT7 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CCT7 TCP1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
IGBP1 PPP2CA â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
PPP2CA PPP2R1A â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
H2AFX ATM â—¼   PHYSICAL_INTERACTION 105.0 1.0 ACSN 11283614 11331603 11571274 11850621 11877377 12086603 12202749 12234250 12556884 12607003 14614141 14988723 15136767 15140942 15175241 15211575 15242590 15279786 15375219 15377654 15385537 15459660 15485915 15496928 15498778 15549137 15655342 15798197 15964794 16163361 16332722 16449207 16531125 16713580 16805667 16818604 16858402 17055429 17102137 17116323 17116885 17296725 17303408 17384638 17582221 17660363 17965729 18001824 18001825 18006705 18087292 18171670 18171986 18212739 18398454 18469862 18524993 18543256 18558713 18583988 18584027 18590585 18678890 18809224 18995830 19151707 19202191 19217833 19270065 19282663 19342888 19362533 19490890 19622404 19654615 19686080 19772495 19793801 19892829 20021983 20027199 20051983 20064462 20160076 20691907 20713526 20723763 21376743 2191300 22657828 22743550 23030059 23082994 23161013 23253856 23847781 24036544 24050180 24089143 24095737 24709898 7575488 9407949 9488723 9721205
H2AFX ATM â—¼   SHARES_COMPLEX 105.0 1.0 ACSN 11283614 11331603 11571274 11850621 11877377 12086603 12202749 12234250 12556884 12607003 14614141 14988723 15136767 15140942 15175241 15211575 15242590 15279786 15375219 15377654 15385537 15459660 15485915 15496928 15498778 15549137 15655342 15798197 15964794 16163361 16332722 16449207 16531125 16713580 16805667 16818604 16858402 17055429 17102137 17116323 17116885 17296725 17303408 17384638 17582221 17660363 17965729 18001824 18001825 18006705 18087292 18171670 18171986 18212739 18398454 18469862 18524993 18543256 18558713 18583988 18584027 18590585 18678890 18809224 18995830 19151707 19202191 19217833 19270065 19282663 19342888 19362533 19490890 19622404 19654615 19686080 19772495 19793801 19892829 20021983 20027199 20051983 20064462 20160076 20691907 20713526 20723763 21376743 2191300 22657828 22743550 23030059 23082994 23161013 23253856 23847781 24036544 24050180 24089143 24095737 24709898 7575488 9407949 9488723 9721205
H2AFX ATM â—¼   ENZYMATIC_REACTION ✅ 105.0 1.0 ACSN 11283614 11331603 11571274 11850621 11877377 12086603 12202749 12234250 12556884 12607003 14614141 14988723 15136767 15140942 15175241 15211575 15242590 15279786 15375219 15377654 15385537 15459660 15485915 15496928 15498778 15549137 15655342 15798197 15964794 16163361 16332722 16449207 16531125 16713580 16805667 16818604 16858402 17055429 17102137 17116323 17116885 17296725 17303408 17384638 17582221 17660363 17965729 18001824 18001825 18006705 18087292 18171670 18171986 18212739 18398454 18469862 18524993 18543256 18558713 18583988 18584027 18590585 18678890 18809224 18995830 19151707 19202191 19217833 19270065 19282663 19342888 19362533 19490890 19622404 19654615 19686080 19772495 19793801 19892829 20021983 20027199 20051983 20064462 20160076 20691907 20713526 20723763 21376743 2191300 22657828 22743550 23030059 23082994 23161013 23253856 23847781 24036544 24050180 24089143 24095737 24709898 7575488 9407949 9488723 9721205
ATM MDM2 â—¼   ENZYMATIC_REACTION ✅ 54.0 1.0 ACSN 11331603 11438669 11804596 11877377 12086603 12556884 12607003 14988723 15136767 15140942 15175241 15459660 15485915 15798197 15867354 15964794 16163361 16332722 16581787 16713580 16731533 16805667 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17713585 18006705 18048416 18469862 18511906 18583988 18716619 18756267 18995830 19151707 19282663 19342888 19357644 19490890 19622404 19788416 19793801 19793861 19841479 20019063 20051983 21376743 23847781 9168117 9858600
H2AFX ATM â—¼   REGULATES ✅ 105.0 1.0 ACSN 11283614 11331603 11571274 11850621 11877377 12086603 12202749 12234250 12556884 12607003 14614141 14988723 15136767 15140942 15175241 15211575 15242590 15279786 15375219 15377654 15385537 15459660 15485915 15496928 15498778 15549137 15655342 15798197 15964794 16163361 16332722 16449207 16531125 16713580 16805667 16818604 16858402 17055429 17102137 17116323 17116885 17296725 17303408 17384638 17582221 17660363 17965729 18001824 18001825 18006705 18087292 18171670 18171986 18212739 18398454 18469862 18524993 18543256 18558713 18583988 18584027 18590585 18678890 18809224 18995830 19151707 19202191 19217833 19270065 19282663 19342888 19362533 19490890 19622404 19654615 19686080 19772495 19793801 19892829 20021983 20027199 20051983 20064462 20160076 20691907 20713526 20723763 21376743 2191300 22657828 22743550 23030059 23082994 23161013 23253856 23847781 24036544 24050180 24089143 24095737 24709898 7575488 9407949 9488723 9721205
AURKB ATM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22099307 27493659
PPP2CA ATM â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 15510216
ATM SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 23148884 18619531 22826432 27156884 29144413 29294106 23046908 17609267 18171990
ATM EIF4EBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 9806882 17525332 10713094 21315178 17570479 26777338 10608806 11146653 12588975 18212344 29152614
ATM MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 66.0 1.0 Omnipath 14654783 12383858 17936559 20651945 17303408 19816404 10611322 23150762 23277204 23386996 26416444 27258263 23002429 11331603 15865937 21556066 16163361 23708100 17570479 20514355 22264782 27177180 18265945 28690977 23847781 22264786 15140942 15964794 19788416 22624716 25201202 27462439 12607003 28050229 32350255 22649771 27956626 15459660 22976441 25247188 28904407 11877377 21859827 24534650 23405218 29290977 27568562
ATM SMC1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 43.0 1.0 Omnipath 17303408 14657349 19690332 29988990 26673124 15302935 16163361 20068231 18452278 18077418 17570479 18669648 23847781 15964794 16906133 12607003 9789013 17525332 15459660 11877376 11877377
BRCA2 H2AFX â—¼   PHYSICAL_INTERACTION 49.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BRCA2 H2AFX â—¼   SHARES_COMPLEX 49.0 1.0 ACSN 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 9488723
AKT1 CLK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20682768
AKT1 FOXO3 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11154281 11715018 11923280 15169778 17680028 20214616 20398329
MDM2 FOXO3 â—¼   ENZYMATIC_REACTION ✅ 14.0 1.0 ACSN 11715018 11779693 11923280 14761977 15024084 15084260 15169778 15876864 16307918 17110379 17158541 19321440 20679392 9450543
FOXO3 AKT1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 15987244 10358075 10102273 12857750
FOXO3 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19424579 23517348 21752881 22539004 11278373
CTNNB1 FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 15905404 21071413 17254970
MAPK14 FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22128155 23857333
PPP2CA FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19029949 15207915 20110348 17322870
AKT1 FOXO3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 64.0 1.0 Omnipath 19951971 11756412 11953455 11923280 20452955 21798082 20398329 21329882 10217147 11154281 11994454 23331499 10995739 19216069 20214616 11463845 21775285 20068231 9829964 17570479 10102273 18593906 17646672 16680151 18988627 21621563 15169778 17522590 25241761 23109003 11715018 19188143 15023346 17680028 26192618 11864996
MAP2K3 MAPK14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 91.0 1.0 Omnipath 12589052 11279118 17081983 20213747 7914033 18767875 17322306 23602568 8622669 18855897 19690332 23904011 9162092 11426938 15592455 18083107 7997261 12384504 15735649 18291705 23331499 17389395 7535770 19534553 7839144 21071413 16083285 21614932 20068231 12738796 16189514 17255949 18669648 16153436 14970210 26186194 16407200 11242034 18691976 18088087 11304531 15972258 10781613 17192257 18586681 10734320 19651622 7592586 16157584 19369195 9582275 15674326 9528766 7693711 9841871 12758252 11309380 7750576 15212693 15659558 11274345 15735648
MAPK14 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 26822034 17726008 21303975 18451303
MAPK14 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 23331499 10201984 18691976 17502367 17570479
MAPK14 EIF4EBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 35.0 1.0 Omnipath 17081983 11691836 18767875 12665511 17043358 19413330 10405182 19664995 10942774 9092573 20068231 9465032 11777913 18669648 8083223 12105188 17287340 9405468 12370290 19651622 10779345 10364159 12912989
MAPK14 EZH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 21902831 30022044 17570479 27494834 28067271
MAPK14 ARRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12738796 18039929 11274345 15187187
MAPK14 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 23331499 10201984 17897103 18669648 18691976 11226159 17502367 7543024 19690332 15322115 14963018 25950470 28262979
MARK2 MAPT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 7706316 28066266 9108484 23666762 23001711 17360912 17573348 21311567 22952452 24251416
GSK3B MAPT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 141.0 1.0 Omnipath 19616957 22278060 25641096 9832145 19562805 12387894 24268883 9546672 31640277 21865886 19413330 28386764 28379300 1330687 28734998 19415658 15302935 17047304 7706316 27349344 29408874 9716264 9353289 21671254 24165324 12714590 20068231 12387897 17570479 16452634 25815351 21215781 16568235 16519507 8999860 17045592 9565682 27857758 11181841 14690523 22690349 27073700 21443865 10601262 7566346 10737616 15522877 12435421 17287340 9771888 29725295 15073173 17078951 19651622 1181841 15542598 9735171 12226093 11104762 21985244 20049527 28835279 27965573 20679343 20308788 9199504 18510355 10090741 11311121 2387894
AKT1 MDM2 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11154281 11715018 11923280 15169778 17680028 20214616 20398329
AKT1 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 60.0 1.0 Omnipath 11756412 11923280 20856200 20452955 20398329 18332867 19664995 10217147 11154281 19216069 20214616 11463845 19166854 15527798 9829964 17570479 16680151 17646672 12145204 15169778 15140942 25241761 11715018 25209720 17680028 21930127 11504915 29311840 15574337 23397142
STAT1 STAT3 â—¼   DOWN_REGULATES ✅ - 46.0 1.0 ACSN 10485906 10754326 10820262 10952726 11134049 11399519 11830590 11875494 11964313 12193701 12223527 12433365 12796776 12811837 12907458 12967644 14607900 14607933 14660645 14764699 15465827 15644117 15699106 15814715 16127449 16878026 17016554 17260466 17404308 17485448 17513775 17559085 17689680 18272812 18345002 19833085 19879327 21097505 21263073 21930765 23390297 25960930 6357187 7594497 8683106 8871614
STAT1 STAT3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19122651 17558387 22693070
STAT3 NOS3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 21611796 19754268 19118090 16887796
STAT3 STAT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 25609649 8662591 12070153 31462771 25241761 11722592 8710878 9794795 23268184 15284024 16189514 9535918 11594781
SP1 TERT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 38.0 1.0 Omnipath 24074563 19843528 19047367 15951564 10778946 21536653 19287963 12019268 11452025 19360348 18365874 14577922 19318640 14611815 12368233 15226182 15656906 21553143 15067344 21132266 11342218 16452190 21590772 19649288 17141225 12151407 16234237 17325661 18093727 19106100 18754863 1236823 10637317 21693539 22554713 19912441 11279234
SP3 TERT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11342218 16452190 12151407 19047367 15951564 17548428 11279234
AKT1 TERT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 25999477 22366458 10224060 17570479 22902867 15843522 18775701
IGBP1 PPP2CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 23892082 21988832 20092282 16085932 18782753 24484909 28330616 9647778 21454489 26496610 32296183 24145130 19156129 11371618 10441131
PTEN AKT1 â—¼   DOWN_REGULATES ✅ - 22.0 1.0 ACSN 10753747 11747822 12040186 15721744 16288286 16982858 17218262 17409395 19440036 19847259 19945467 20609352 21084277 22179046 22465479 23732914 24030100 24254977 25364523 26597054 27328425 27572739
GSK3B PTEN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 25.0 1.0 Omnipath 20080742 19797085 16107342 12040186 23379765 16611981 10671551 16039586 17570479 12615961 25763354 19575820 17444818 20537194 26339505 23210979 17052453 18455992 16371461 11274345 12297295
AKT1 PTEN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 19903340 15987703 10790335 20596030 10592173 20605778 10866658 12077256 11035045 16107342 12297295
AURKB RACGAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 15630414 14744859 19007248 17178910 19555392 18201571 17287340 12689593 15108802 18669648
SP1 CAV1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15531587 10684646 23280667 21631282 17108117
SP3 SP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 21554857 12509426 9632663 10362515 19223508 15857802 20096088 16806531 15854045 15118068 9788252 12773549 16617124 11517158 12554796 9666093 15869407 12888570 11287330 15541732 8845379 16574784 8070411
SP1 NOS3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 12759366 19105596 15722551 18624763 12684688 9614091 10574932 10713142 15061658 12270858 15180995
SP1 F3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 12483323 8576248 15636197 7615158 10707957 9081693 7876129 10551840 9198250
SP1 AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19145069 15342781 21520171 18353772
SP1 CYP17A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 14988427 11463853 9112400 15001547 11379008
SP1 PPP2CA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19750005 19420015 12076969 21420382
PPP2CA AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 35.0 1.0 Omnipath 21159657 26256536 15743829 10026142 20452955 11438723 18559511 11839802 19996169 19216069 16406523 10995457 18042541 19556239 18588945 16680151 11087733 18160256 15367694 18039929 18077353 11812651 16044149 20360384 12637511
AKT1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 20858269 23331499 20028971 11882383 21303971 17680028 20214616 22094462 17287208 17374729 20398329 21506126 21402455 12040186 19623618 12063252 18218901
AKT1 EZH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 22391560 24526064 29864144 34230470 16224021 26517694
AKT1 NOS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 70.0 1.0 Omnipath 12759249 20166139 11756412 10376603 11923280 12446767 16697215 11044445 20398329 18372248 11696579 16126727 16839566 15808505 20138985 20299462 10908731 20363286 11988487 11425855 20214616 23103584 11729179 16043647 17570479 12171920 25460366 27322328 11978735 15169778 11029403 25241761 19654415 10949026 18048761 11715018 12791703 24379783 18636226 9812896 23397142 17680028 10376602 12431978 10722653 20832730 18570873 25009123 17052453
AKT1 GSK3B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 99.0 1.0 Omnipath 17428466 15207235 17145710 12052830 10729337 8250835 11756412 11923280 16914735 17623045 16697215 8524413 12054501 20398329 18372248 21506126 20028971 12040186 15808505 16543730 20138985 23331499 21303971 16009706 10385618 20214616 23180781 9373175 16039586 15829723 18988627 16282323 11577096 11035810 18669648 18216173 15169778 12851486 16123141 11882383 23109003 9065430 18691976 22094462 10949026 22710759 11715018 12459251 18636226 17192257 11254732 11278246 20858269 9812896 9582355 15023346 17680028 19369195 7945242 12900420 23552696 18387957 10722653 20832730 18570873 12147701 18505846 17052453 17693255 18218901
AKT1 EIF4EBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 17081983 11691836 18767875 12665511 19413330 10405182 19664995 10942774 9092573 20068231 9465032 11777913 18669648 8083223 12105188 17287340 9405468 12370290 19651622 10779345 10364159 12912989
GSK3B HDAC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 21118993 18045992
PPP2R1A PPP2CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 35.0 1.0 Omnipath 21159657 23443559 19818709 19293187 24841198 28330616 18715871 19915589 18782753 33633399 17274953 26496610 17540176 15761952 17374643 17529992 22379092 17055435 8617797 12370081 17632056 16039140 16769727 19156129
PPP2CA ARRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 18039929 16680151 10995457 18042541 18588945
PPP2CA PRKCB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 15880462 8749392
PPP2CA RACGAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 18201571
GSK3B MARK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 16257959 18424437 28236972
GSK3B CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 183.0 1.0 Omnipath 22415718 11967263 27158593 29455668 19303846 19797085 8638126 19293931 23056571 22662165 25352148 16611981 27068260 28337019 10671551 21743491 20688898 16293724 23721711 23552738 18687691 28977889 19622173 12051714 25241761 27683053 28549350 22699938 19565571 23076981 21562161 19575820 20219694 20537194 10330181 21986938 29183346 27773936 11251183 19711366 21035499 19675674 7542250 23151663 24451375 14663202 23804296 8524413 25639486 23770025 18070361 26892600 30143633 9233789 19667122 27507058 19061640 19223551 29387014 23331499 16199882 11533658 18644116 24501426 24913829 11835406 17318191 26014148 25366337 28183999 22640743 26910375 12000790 12114015 18387957 19107203 9832503 16371461 29805709 27462866 20137080 27902311 12040186 19576224 25644994 12615961 19060929 25897075 12851486 15465828 17053159 18952601 10228155 15020233 17444818 20140245 26453498 17052453 16944320 24015932 23602568 24975844 24931005 28948000 20080742 23209942 30271168 28220106 16520547 28430641 11818547 25546293 27672271 11955436 11154277 26373837 16039586 23778311 28697793 20302655 25136145 26905812 22216350 8666229 12957350 23109003 10074433 28529629 20215423 21329734 11254732 9501208 27098453 27281614 30279527 19631635 25482131 18455992 24403311 11274345
GSK3B CCNE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 38.0 1.0 Omnipath 16944320 11967263 14663202 8524413 8861947 16039586 17570479 14536078 12615961 19561641 15465828 25241761 18691976 18319725 12459251 15020233 20537194 11124803 16131838 9832503 15364936
GSK3B MYOCD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 16141410
GSK3B EIF4EBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 23584478 17570479 27387559 18701453
PRKCB NOS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 24379783 24790142
SP3 NOS3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 14555463 12759366 15180995