Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
TPT1 ATM â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1106300109 22451927
SUMO2 ATM â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22661230 22635276
ATM H2AX â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1106300109 22451927
SP1 ATM â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15837784 11466608
ATM H2AX â—¼   COLOCALIZATION 2.0 0.8 intact 16858402 5218840
IRS1 ATM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18762365
MCPH1 ATM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16217032
ATM PLK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12147700
TP53 BCL2L11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19427386 20124456
BLM PLK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16864798 0601828103
XRCC3 BLM â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 24509834 23509288
RAD51C BLM â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 24509834 23509288
ESR1 BLM â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17268063
BRCC3 BRCA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19202061 0807485106
BRCA2 BRCA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19369211 0811159106
TP53BP1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15970701 21914189
EP300 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23353771 23285190
PIAS4 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21113239
MCPH1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15220350
TP53 BRCA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1003689107 20421506
NCL BRCA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
BRCA2 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
SYCP3 BRCA2 â—¼   COLOCALIZATION 2.0 0.8 intact 22116401 8303438
MCPH1 BRCA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19549900
CASP8 CASP3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18669646 0712034105
CASP3 STK4 â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 9545236 11278283
CASP3 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9500443
CASP3 TP73 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18362891
TEAD1 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20153295 22286761
CTCF CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18625744
TP73 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16526280 22842668
CUL1 CHEK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17290223 5219620
CHEK1 TP53 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5218401 16511572
RPA2 CHEK1 â—¼   COLOCALIZATION 2.0 0.8 intact 20639859 8010047
CHEK1 FANCL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19861535
TP53 DDB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11971958
RPA1 DNA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18593712 23604072
RPA2 DNA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18593712 23604072
RPA3 DNA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18593712 23604072
E2F1 MCM8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16325355
E2F1 MCPH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22136275
E2F1 ULK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18408756
E2F1 MAP1LC3A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18408756
E2F1 PLK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24076372 18439978
E2F1 POLD1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11799067
E2F1 MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18396012
PTEN E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17218262
E2F1 MCM3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18319725 12909625
E2F1 FGFR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18319725 12944911
E2F1 RBBP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18319725 12909625
EP300 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23403292 24998469
ESR1 EP300 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16704985 11279135
NBN EP300 â—¼   COLOCALIZATION 2.0 0.8 intact 21108945 8058069
TP73 EP300 â—¼   ACETYLATION ✅ 2.0 0.8 intact 11804596 5215037
EP300 RELA â—¼   ACETYLATION ✅ 2.0 0.8 intact 5214468 11533489
EP300 WRN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20428248
EP300 H2AX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20488183
POLD1 FEN1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7876218 8131753
POLA1 FEN1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7876218 8131753
RPA1 FEN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15592449
HNRNPC GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
SP1 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
NELFB GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
SPTA1 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12700044 2809592
POLD1 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
GRB2 NCL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 UGDH â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 EHMT2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
GRB2 PPP3CB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
GRB2 FLNA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
MAPK1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8994038
CEBPB HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9880553 10440232
CEBPB HSP90AA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18266962
ESR1 MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23250869 22430216
MAPK1 MAP2K1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 23241949 8412360
MAPK1 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8941362
SUMO2 MDC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22661230 22635276
SP1 MDC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18173747
MSH6 MSH2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6548274 9774676
TP53 MSH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12209975
NBN SUMO2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22661230 22635276
H2AX PALB2 â—¼   COLOCALIZATION 2.0 0.8 intact 22193777 8329239
MAP1LC3A PIAS4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
RELA PIAS4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0701877104 17606919
SUMO2 PIAS4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
PIAS4 BARD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
CASP8 PLK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PLK1 RECQL5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
PLK1 TP53BP1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 1000287 20126263
PLK1 TP53 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 7266226 19833129
PLK1 TUBG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10191277 16189514
PLK1 SGO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18331714
TP53 PMAIP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10807576
TP53 PML â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216620 12915590
RPA1 POLA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17666013 9214288
TOPBP1 POLA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19652550
TP53 POLD1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11375983
HSP90B1 POLK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
TP53 POLK â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16678112
SP1 POLK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17099721
SUMO2 RAD51 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19956565 1000252
H2AX RAD51 â—¼   COLOCALIZATION 2.0 0.8 intact 8149296 21317870
TP53 RAD51B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9878257
RAD51C RMI1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 24509834 23509288
TP53 RFWD3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0912094107 20173098
RFWD3 RPA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21558276
XRCC3 RMI1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 24509834 23509288
MCM3 RPA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10882098 10757793
RPA1 SUMO2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 24782567 20705237
NCL RPA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15743838
MCM3 RPA3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10882098 10757793
MAP1LC3A SQSTM1 â—¼   COLOCALIZATION 2.0 0.8 intact 19427866 7034152
SUMO2 SYCP3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1004248107 20534433
TOPBP1 TP53BP1 â—¼   COLOCALIZATION 2.0 0.8 intact 8086392 20871591
TP53 TOPORS â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219611 17290218
SUMO2 TP53 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1004248107 20534433
TP53 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10823891 5212595
TP53 BCR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
TP53 CDC42 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
TP53 NCL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22103682 8291914
TP53 CSNK2B â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12393879 11239457
TP53 CSNK2A1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12393879 11239457
TP53 PRKAA1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15866171 24874608
MAX TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7969121 10348347
TP53 MAP2K1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10529175 9724739
TP53 HNRNPC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18296503 21317560
XPO1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17268548 17891139
TP53 FASLG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10969818
TP53 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10766163 16713569
TP53 BARD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14636569 15782130
TP53 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18431400
SUMO2 TP53BP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22661230 22635276
RELA TP53BP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8910340 8524315
TP73 PDGFRB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19952113 15454570
CASP8 TP73 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18362891
TPT1 H2AX â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 1106300109 22451927
CREBBP WRN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20428248
H2AX SUMO2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22661230 22635276
VASP ACTB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10592173 1318192
PTEN CSNK2B â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12297295 11035045
CSNK2A1 CSNK2B â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
HMGXB4 HSP90B1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
GLI2 CDC73 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22982193 19368795
ESR1 TFF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 6593703
PTEN PDGFRB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16456542 5218301
LRP6 PDGFRB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 21245321 1019443108
PTEN FLNA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 3002166 21653829
PRKACB FLNA â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5217066 15225631
GNAS ADCY3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9228084 21406690
GLI2 IFNGR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 14691458
PTEN CSNK2A1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 12297295 11035045
RELA PTEN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 14729949
CDC42 PTEN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 16381926
PTEN RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 10753747
PTEN SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12804776
FZD4 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 27096005 19388021
CASP8 NCL â—¼   COLOCALIZATION 2.0 0.8 intact 5219611 17290218
CSNK2A1 RELA â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 5212888 10938077
ESR1 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23403292 24998469
ESR1 RAC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21118977 11060289
PRKACB GLI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19996099 20027184
SP1 CCNE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16516150 15818598
SP1 MAP2K1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17889508 16452190
CEBPB IL24 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10942517
MITF BRAF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23831555 16001072
ESR1 AICDA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23181348 19139166
ESR1 HSP90B1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16511840 23038705
SUMO2 CTBP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20176810 20098713
XPO1 AGO2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19955415 0912384106
AGO2 XPO1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19955415 0912384106
GNA12 BTK â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11742120 9796816
CBX4 CTCF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19029252
VASP PFN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
BLM RPA2 â—¼   PHYSICAL_INTERACTION 801.0 0.8 STRING 36370105
ATM RBBP8 â—¼   PHOSPHORYLATION ✅ - 0.8 0.8 Signor 10910365
ATM WRN â—¼   PHOSPHORYLATION 0.8 0.8 Signor 10608806
BCCIP RAD51 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 15713648 27694622
ESR1 BRCA1 â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 1204073 5215931 11244506
H2AX BRCA2 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 18406329 20936109
SUMO2 MDC1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 22661230 19394292 19471022 32786267
MSH4 RAD51 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 11950880 15489243
RAD51 MCPH1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 19549900 20107607 32735676
SUMO2 CBX4 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 19471022 15175327 20098713 21252943 21693764
PDGFRB PTEN â—¼   PHYSICAL_INTERACTION 811.0 0.81 STRING 36370105
CHEK1 RAD51 â—¼   PHOSPHORYLATION ✅ + 0.81 0.81 Signor 15665856
MDC1 UIMC1 â—¼   PHYSICAL_INTERACTION 817.0 0.81 STRING 36370105
SNX32 BRCA2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
MDC1 BRCC3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22990118 29656893
ACTB EP300 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33742100 21988832
CTBP1 EP300 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21102443 15834423 35016035 16122695
ESR1 EP400 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21182205 31527615
RAC1 GRB2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 31980649
MSH2 MCM8 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33961781 26300262
MDC1 BRE â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22990118 29656893
ESR1 MSH6 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 16260778 31527615
SNX32 RAD51 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
SUMO2 WRN â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 16524884 19471022
CTBP1 H2AX â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34133714 31041561
FGF3 H2AX â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
H2AX CTCF â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
ESR1 CTBP1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 23403292 31527615
STK4 XPO1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 26673895 23386615
ATM CHEK1 â—¼   PHOSPHORYLATION ✅ + 0.82 0.82 Signor 20068082
BLM RPA3 â—¼   PHYSICAL_INTERACTION 822.0 0.82 STRING 36370105
ATM MDC1 â—¼   PHOSPHORYLATION ✅ + 0.82 0.82 Signor 12607003
GRB2 PDGFRB â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
NBN TERF2IP â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
RAD51B RAD51D â—¼   PHYSICAL_INTERACTION 826.0 0.82 STRING 36370105
PLK1 BRCA1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 25483079 24067368 31730000 29656893
MLF1 BRCA2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
CDK5 CCND1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 23455922 21654808 33961781
BARD1 MDC1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 12611903 29656893
TEAD1 RAD51 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
RPA2 ESR1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 11953755 31527615
CDK5 CCNE1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 23455922 33961781 23602568
EHMT2 CTBP1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 17967884 31041561 16702210 33961781 26186194
BRCA1 RBBP8 â—¼   UBIQUITINATION ✅ + 0.83 0.83 Signor 16818604
RBBP8 BRCA1 â—¼   RELOCALIZATION ✅ + 0.83 0.83 Signor 24832651
ATM NBN â—¼   PHOSPHORYLATION ✅ + 0.83 0.83 Signor 10802669
CCND1 EP300 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
ESR1 TP53 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
TP53 USP10 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
BRAF MAPK1 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
FEN1 WRN â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
CCND1 CUL1 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
MSH2 BLM â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 10783165 15064730
SUMO2 BLM â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 21693764 16524884 16620772 19471022
MSH6 BLM â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 10783165 15064730
BLM H2AX â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 15364958 29523790
DNA2 FEN1 â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
MDC1 RAD51 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 28973861 16186822
PDS5B PALB2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 22293751 27924011
PDS5B RAD51 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 22293751 27924011
BARD1 H2AX â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 12485996 11927591
CEBPB SP1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 16651265 12847250 12665574
ESR1 EHMT2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 21984853 31527615
RAD51 RAD51C â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
PIAS4 SUMO2 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
BARD1 BRCA2 â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
CSNK2A1 PML â—¼   PHYSICAL_INTERACTION 844.0 0.84 STRING 36370105
KEAP1 PALB2 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HuRI 32296183
AGO2 HSP90AA1 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
BARD1 TP53 â—¼   PHYSICAL_INTERACTION 848.0 0.84 STRING 36370105
SUMO2 BRCA1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 20016603 20016594 22689573 21693764 21147198
BRCA1 WRN â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 16714450 24709898 29656893
EP300 MCM3 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 20808282 30110629 33742100
FANCM RMI1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 20064461 17289582 20347428 22392978
GRB2 FLNA â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 17474147 12577067 21706016
MCM9 MCM8 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 28514442 26300262 26215093 33961781 26186194 26870752 23401855
ESR1 FLNA â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 21182205 19805454 25604459
CEBPB ESR1 â—¼   PHYSICAL_INTERACTION 849.0 0.85 STRING 36370105
PTEN TP53 â—¼   PHYSICAL_INTERACTION 852.0 0.85 STRING 36370105
CEBPB EP300 â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
TP53 XPO1 â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
MDC1 TOPBP1 â—¼   PHYSICAL_INTERACTION 855.0 0.85 STRING 36370105
E2F1 EP300 â—¼   PHYSICAL_INTERACTION 857.0 0.85 STRING 36370105
EP400 MAX â—¼   PHYSICAL_INTERACTION 857.0 0.85 STRING 36370105
BRCA1 WRN â—¼   PHYSICAL_INTERACTION 858.0 0.85 STRING 36370105
NBN BLM â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 29523790 10783165
BRCA1 ABRAXAS1 â—¼   PHYSICAL_INTERACTION ✅ 0.86 0.86 mint 34591612
BRCA1 FLNA â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 22990118 20305393 16713569 26831064
MCM9 MSH6 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 26300262 26870752
H2AX NBN â—¼   PHYSICAL_INTERACTION ✅ 0.86 0.86 mint 6805208 18583988
H2AX NBN â—¼   COLOCALIZATION ✅ 0.86 0.86 mint 22565321 8391733
NBN H2AX â—¼   COLOCALIZATION ✅ 0.86 0.86 mint 22157895 8303386
LRP6 FZD8 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 11448771 11029007 15908424
NSD3 ESR1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 25640309 31527615
BRCA1 MSH2 â—¼   PHYSICAL_INTERACTION 862.0 0.86 STRING 36370105
BLM MSH6 â—¼   PHYSICAL_INTERACTION 864.0 0.86 STRING 36370105
TP53 WRN â—¼   PHYSICAL_INTERACTION 866.0 0.86 STRING 36370105
CCND1 ESR1 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
ATM H2AX â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 16858402 27918549 22184063 9488723 32518374 20081839 18344987 21676867 22451927 21704408 11571274 11893489 26095369
SP1 BRCA1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 14710355 16713569 12706836 10720440 17766039
BRCA2 XRCC3 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 26496610 18212739 24141787 20450923 16621732
BRCC3 BARD1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 14636569 17664283 17525341
CASP8 CASP3 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 15254227 11832478 18669646 11437602 8962078
CCND1 XPO1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 21654808 12529437
BARD1 MSH6 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 16391231 11498787
PALB2 RAD51 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 26833090 22193777 20332121 28319063 22331464 20871616 24141787 33961781 19584259 28240985 23585894 20871615 29499138 25016020 28398198 16793542
PIAS4 SUMO2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 19471022 15383276 16713569 19394292 16524884 32786267 20016603 20696768 21252943 22578841 21693764
SUMO2 PML â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 17000644 16189514 23543742 28851805 19553342 21148299 22155184 24190887 20826694 21779164 22578841 17081986 21693764 24637324 15940266 20797634 9452416 19471022 16713569 25027693 21252943
H2AX RAD51 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 31009828 30560944 21317870 28796254 29499138 28190324 10959836
RAD51 WRN â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 17118963 18562274
ESR1 UIMC1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 17311814 31527615
WRN H2AX â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 20802463 15733840
ESR1 ACTB â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 31527615 20308691 19805454 21182203 21182205 20348541
HRAS BRAF â—¼   PHYSICAL_INTERACTION ✅ 0.87 0.87 mint 34591642
HRAS BRAF â—¼   PROXIMITY ✅ 0.87 0.87 mint 30194290
BCR RAC1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 9535855 31871319
ESR1 SP1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 10681512 17656465 17312152 16651265 18765668 10446910 15084343 16439465 15637147 19652226 15705965 15987735 9611253 15557281 9328340
PIAS1 ESR1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 11117529 15666801 31527615
UHRF2 CCNE1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 21952639 15178429
RFWD3 RPA2 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
RFWD3 RPA1 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
MAP1LC3A ULK1 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
ENAH VASP â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
BRCA1 CREBBP â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
ENAH EVL â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
EVL VASP â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
FEN1 MSH2 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
CSNK2A1 TP53 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
BRE UIMC1 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
CASP8 FASLG â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
CBX4 CTBP1 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
BLM CHEK1 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
BLM TP53 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
PIAS1 TP53 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
BRCA1 MDC1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
BRCA1 TUBG1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
BRCA1 TOPBP1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
RELA SP1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
ATM BRCA1 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
BRCA1 TP53BP1 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
BRCA1 NBN â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
CHEK1 TP53 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
EP300 TP73 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
BLM FEN1 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
MAPK1 TP53 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
E2F1 TOPBP1 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
CREBBP ESR1 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
BRCA1 BLM â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 25084169 10783165 26831064 29656893
BRCA1 RPA1 â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
CTBP1 BRCA1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 21102443 16713569 10196224 31636387 11751867
BRCA2 PDS5B â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 22293751 27924011
BRCA2 BRCC3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 14636569 17664283
EP300 CCND1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 15951563 10567390 11788592
CUL1 E2F1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10559858 11245432
NBN EP300 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 21108945 16051665
SP1 EP300 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 15647279 19062177 10651903 11517158 23714681 10899165 16478997 11030335 24530506 34252870 28425985 31536933 32115405 17623675 10362258 16734381 17906698 22415975 12200149
ENAH EVL â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 33961781 21398369 26344197
FANCM FANCL â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16116422 20347429 20347428 27398742 22343915 18174376 17396147 24910428 18285517 17289582 16720839
MCM9 MSH2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 33961781 26300262 26870752
RAD51 XRCC3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 15065660 17302439 11842113 28864920 9660962
SUMO2 UIMC1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 19471022 23211528 32786267 22689573 21693764 26719330
BARD1 UIMC1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 19615732 17525341
UIMC1 BRE â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 21282113 19261749 19261746 19261748 17525341 20656689 19015238 19615732
CDC42 RAC1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 31871319 9427749
PIAS1 SUMO2 â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
ATM BLM â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
BRCA2 SHFM1 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
TOPORS TP53 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
BCR GRB2 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
KEAP1 MCM3 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
NBN RBBP8 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
RAD51 RAD54L â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
PML TP53 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
POLD1 RPA1 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
ESR1 HSP90AA1 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
MDC1 ATM â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 29656893 14519663 28943310 12607005 26734725 18006705
BCCIP BRCA2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11313963 15713648
BLM FEN1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 14688284 16326861
NBN BRCA1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10426999 18171670 19244116 12124328 10783165 25659039 25184681 25939603 11504724 29656893
MDC1 BRCA1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 21622030 19766185 15569676 12611903 17525332 12607005 29656893
CCND1 BRCA1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17334399 16713569 9244350
UIMC1 BRCC3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 18077395 19305427 21282113 19261749 19261746 23264621 19261748 19202061 17525341 20656689 19015238 19615732
BIRC7 CASP3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11024045 23563149 11084335
E2F1 MCPH1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 23001041 18660752 23697381
MAX EP400 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11509179 33961781 25609649 29028833 20946988
VASP EVL â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 21398369 33961781 26186194 34079125 26344197
FGFR2 GRB2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24440983 22726438
PALB2 KEAP1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 32296183 31257023 26649820 25016020 22331464 30126895 33961781 28416489 28398198
KEAP1 MCM3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24322982 30126895 27621311 30108253 23382044 28416489
UIMC1 MDC1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 21622030 22990118 21857162 24240613 29656893
BARD1 RAD51 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 14636569 32347575 28976962 25252691
VASP ENAH â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 21398369 33961781 26186194 34079125 26344197
RAD51 TP53 â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
CREBBP RELA â—¼   ACETYLATION ✅ + 0.89 0.89 Signor 16382138
FGF7 FGFR2 â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
FGFR2 GRB2 â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
MORF4L1 PALB2 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
RPA1 ATM â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18171670 11080452 17965729
RPA3 ATM â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18171670 11080452 17965729
RPA2 ATM â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18171670 11080452 17965729
ATM BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11114888 11278964 29656893 10783165 11016625 10866324 10550055 15713674 18344987 10608806 17478428
ATM NBN â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 24800743 10783165 25088203 11252893 30952868 10608806 17507690 22464731 25895060 10839545 15758953 10839544
ATM BLM â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 29523790 10783165 12034743
TP53 ATM â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 9843217 9733515 9733514
E2F1 ATM â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22832221 23993922 12527885
BCCIP CSNK2B â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
E2F1 BCL2L11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23152504 19893569 16243973
RMI1 BLM â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 20360068 20826342 23509288 24239288 26496610 15775963 20064461 20711169
H2AX BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12485996 34321665 19766185 18001824 31501894 11927591 18344987 20681793 26095369 18001825 29499138 19805520 26121674 10959836 12419185
PALB2 BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19369211 25184681 19584259 23038782 29656893 26649820 30337689 28319063 28089683 28398198 22193777 19268590 22331464 34408138 23585894 25016020 19553677 24085845 25652403
ESR1 BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19887647 1244506 11782371 15674350 29367421 27977889 17392432 16860316 10334989 16260778 11244506 16061635 12400015 17505062 20060929 25499220 16713569 31527615 11493692
EP300 BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21102443 19887647 10655477 11782371 16713569 21212407 22787115
BRE BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 14636569 22990118 25184681 29656893
NELFB BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12612062 11739404 16713569
RAD51 BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31270457 31009828 11498787 16713569 19766185 25659039 19369211 25499220 9774970 28319063 17302439 9008167 14636569 28976962 24085845 34408138 29656893
BRCA2 BRCA1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11477095 17664283 16713569 21135251 19369211 9774970 25184681 14636569 24085845 34408138 25652403 14499622 29656893
BRCA1 MSH6 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16260778 25184681 11498787 10783165
BRCA1 MSH2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11498787 16713569 10783165 15886699 16260778
BRCA1 BRCC3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19305427 17664283 19202061 22990118 25184681 14636569 25252691 29656893
BRCA1 UIMC1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21622030 17525340 25184681 17525341 17643121 29656893 19305427 26446986 25252691 26027929 28569838 19766185 19261748 34408138 29499138 19615732 17525342 17621610 31932421 24085845
CTCF BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15252835 24725430 19466541
CASP3 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12149654
BRCA1 RAD51 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16713569 9774970 9008167
PALB2 BRCA2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 20332121 19369211 24485656 17200672 24141787 19584259 28240985 23038782 16793542 26833090 26649820 28319063 24835992 30410870 17420451 28398198 22193777 19268590 21466675 22331464 19609323 26990772 23585894 25016020 19553677 28765325 33961781 20871615 22293751
PLK1 BRCA2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 32286328 14647413 24448238 24835992 28985013 12815053
BRCA2 BARD1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 14636569 17664283 16391231 19176389
RELA BRCA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10961992
CHEK1 BRCA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18317453 24627786
BRE BRCC3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21282113 19261749 19261746 30755420 19261748 17353931 20656689 14636569 33961781 20032457 19615732
CCND1 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16061635 9039267 11073968
CEBPB CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22242598 11162569 12810706
GLI2 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14691458 12533516
UHRF2 CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 21952639
BARD1 DNA2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 16697054 19772495 19847258
E2F1 POLA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18347061 7929342
E2F1 RELA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24755270
EP300 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10753885 15123636 15126619
SP1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10547281 8657141 10850422
E2F1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19276347 21625432
E2F1 POLA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15014447 11491305
E2F1 CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15240700 12389032 18319725
E2F1 RPA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11313881
EP300 CEBPB â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28428115 9343424 14630807 12471036
EP300 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19887647 11782371 12738788 25728767 11867769 12479814 23065768 15308690 20388208 14761960 22227247 8799122 20348541 23403292 12714702 11581164 16713569 19838210 18765668 16645043 30418174 12574227
EP300 FEN1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11430825 20019387 16326861
ERCC5 ERCC2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 32245994 8652557 16713569
TP53 ERCC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 8612585 16713569 7663514
EVL SPTA1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 16336193 7148458 20050024
WRN FEN1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16326861 12356323 11598021 14657243 14688284
CDC42 GRB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
HRAS HSP90AA1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16024644 15118125 15284455
BRAF MAPK1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16508002 14654779 19933846
MAPK1 MAP2K1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 10567369 19219045 8013650
MAPK1 RAC1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 17202194 15657136 21419341
MAPK1 MAP2K2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 10567369 19219045 8013650
MAPK1 CSNK2A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19941816
MDC1 H2AX â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21622030 16377563 19234442 28242625 32518374 20159462 21676867 12475977 14519663 15201865 12607005 21293379 30598506 18001825 29499138 26734725 18001824 18583988
MDC1 NBN â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15377652 30179224 12607003 18678890 29656893 27590578 25064736 20460517 19804756 23115235 14519663 15201865 12607005 20224574 18001824 18583988
MAX MSH2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12584560 16189514 25241761
TP53 MSH2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11350971 8630028
NBN RPA3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18171670 11080452 17965729
NBN RPA2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18171670 11080452 17965729
NBN H2AX â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11110662 18583988 15733840 16377563 31501894 20081839 23145133 22157895 22941933 21676867 16932743 15201865 18001825 18001824 12419185
CTCF NBN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22951020
PLK1 PDS5B â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 11509732 15737063 21987589
PIAS4 RPA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20016603
SP1 PML â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9819401 21360626 24728382 16713569
TP53 PML â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14992722 18056437 14715247
PML TOPBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12919958 12773567
RPA1 RBBP8 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18171670 11080452 17965729
RPA3 RBBP8 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18171670 11080452 17965729
RPA2 RBBP8 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18171670 11080452 17965729
RFWD3 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20173098
RPA1 BARD1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18171670 11080452 17965729
RPA2 BARD1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18171670 11080452 17965729
RPA3 BARD1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18171670 11080452 17965729
TP53 SUMO2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 24782567 25218447 21900752
TP53 TPT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 14623968 24067374 22157679
TP53 JAG2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16980608
TP53 WRN â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9774636 11427532
H2AX ACTB â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
H2AX MCPH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17599047 22154951
ESR1 BARD1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17275994
SUMO2 CSNK2B â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
PPP3CB FLNA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16442073
SP1 IFNGR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11477089 17339358
GLI2 PRKACB â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 17283082 19056373 16611981
PIAS1 GLI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20711444
SP1 CSNK2A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10849443 19027835
MAP2K1 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11160134
FGFR2 FGF7 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11121055 10950949 7499435 11714710 10339576 7687739 8663044 9582367 1309608
CEBPB ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31527615 16651265 7651415 19652226 9817600
SUMO2 PIAS1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19471022 19394292 16524884 20016603 21252943 22578841 21693764 19217413 18806873
PRKAA1 PIAS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 27256105
SPTA1 ENAH â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 16336193 7148458 20050024
VASP SPTA1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 16336193 7148458 20050024
ESR1 FGF7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15781986 14999240 15311216
ESR1 NOTCH2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19376833
PRKAA1 CTBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 23291169
CBX4 CTBP1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 15592428 20098713 33961781 20361981 12679040 26186194 11583618 9858600 12829790
HDLBP CTCF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 31917284 24725430
BRCA1 ESR1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
BRCA1 TP53 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
HSP90AA1 TP53 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
ESR1 SP1 â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
PALB2 RAD51 â—¼   PHYSICAL_INTERACTION 905.0 0.9 STRING 36370105
RMI1 BLM â—¼   PHYSICAL_INTERACTION ✅ 0.91 0.91 mint 20711169 8048867
BLM RMI1 â—¼   COLOCALIZATION ✅ 0.91 0.91 mint 20711169 8048867
PALB2 BRCA1 â—¼   PHYSICAL_INTERACTION ✅ 0.91 0.91 mint 8329239 22193777
PALB2 BRCA1 â—¼   COLOCALIZATION ✅ 0.91 0.91 mint 28319063
BRCA1 PALB2 â—¼   COLOCALIZATION ✅ 0.91 0.91 mint 8329239 22193777
RAD51C RAD51B â—¼   PHYSICAL_INTERACTION ✅ 0.91 0.91 mint 34591612
ATM TP53BP1 â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
GRB2 IRS1 â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
ATM NBN â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
ATM TP53 â—¼   PHYSICAL_INTERACTION 915.0 0.91 STRING 36370105
EP300 SP1 â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
MDC1 NBN â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
EP300 TP53 â—¼   POLYUBIQUITINATION ✅ - 0.91 0.91 Signor 12690203
GRB2 BCR â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 5214841 11726515
RPA3 RPA2 â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 24126761
RPA1 TP53BP1 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
FANCM RPA2 â—¼   PHYSICAL_INTERACTION 921.0 0.92 STRING 36370105
RAD51C XRCC3 â—¼   PHYSICAL_INTERACTION 921.0 0.92 STRING 36370105
EP300 RELA â—¼   PHYSICAL_INTERACTION 922.0 0.92 STRING 36370105
FEN1 MSH6 â—¼   PHYSICAL_INTERACTION 922.0 0.92 STRING 36370105
BLM XRCC3 â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
CREBBP RELA â—¼   PHYSICAL_INTERACTION 924.0 0.92 STRING 36370105
GRB2 BTK â—¼   PROTEIN_INTERACTION 0.93 0.93 HIPPIE 19380743 20936779
EP300 ESR1 â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
MAP1LC3A SQSTM1 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
EP400 MORF4L1 â—¼   PHYSICAL_INTERACTION 936.0 0.93 STRING 36370105
RAD51C RAD51D â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
FANCM MSH6 â—¼   PHYSICAL_INTERACTION 938.0 0.93 STRING 36370105
MCM8 MCM9 â—¼   PHYSICAL_INTERACTION 938.0 0.93 STRING 36370105
RPA1 WRN â—¼   PHYSICAL_INTERACTION 939.0 0.94 STRING 36370105
BRCA1 PALB2 â—¼   PHYSICAL_INTERACTION 940.0 0.94 STRING 36370105
ACTB PFN1 â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
SP1 TP53 â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
BRCA2 PLK1 â—¼   PHYSICAL_INTERACTION 948.0 0.94 STRING 36370105
RAD51 RPA1 â—¼   PHYSICAL_INTERACTION 949.0 0.95 STRING 36370105
RAD51B RAD51C â—¼   PHYSICAL_INTERACTION 949.0 0.95 STRING 36370105
SQSTM1 MAP1LC3A â—¼   COLOCALIZATION ✅ 0.95 0.95 mint 19427866 7034152
MDC1 TP53BP1 â—¼   PHYSICAL_INTERACTION 951.0 0.95 STRING 36370105
ERCC5 ERCC2 â—¼   PHYSICAL_INTERACTION ✅ + 0.95 0.95 Signor 20840796
BLM TP53BP1 â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
FEN1 POLD1 â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
BRAF HRAS â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
DNA2 RPA1 â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
BRAF MAP2K2 â—¼   PHYSICAL_INTERACTION 958.0 0.95 STRING 36370105
E2F1 SP1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 10850422 10409740 8657141 10547281 8657142
RPA1 RPA2 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 24207024 22939629 26399832 26496610 24981860 16514417 19214185 26344197
SUMO2 UIMC1 â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
CHEK1 TP53BP1 â—¼   PHYSICAL_INTERACTION 967.0 0.96 STRING 36370105
MND1 PSMC3IP â—¼   PHYSICAL_INTERACTION 968.0 0.96 STRING 36370105
BLM RAD51 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 19671661 29523790 12606585 17984114 11309417 11278509 19956565 18562274 15064730
BARD1 BRCA1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 12431996 17525341 29367421 27977889 19916563 12732733 10477523 20060929 23680151 8944023 22110403 12951069 23086937 14638690 27239795 29355525 9788437 11925436 11257228 24289923 14647430 19176389 15184379 9738006 16403807 29180510 11278247 33589814 15265711 15159397 34408138 16713569 19117993 20681793 16391231 11301010 16489000 23416467 17664283 15569676 29858377 19369211 18493658 29656893 20351172 28398198 12485996 32347575 19766185 14636569 10026184 12700228 31270457 11573085 11526114 24085845 25823446 33961781 32092106 18936166 28514442 20215511 25184681 26490435 28948225 12890688 12438698 28262780 26831064 9342365 10635334 15855157 11504724 11773071 25252691 9798686 26350354 21901007 24695549 12887909 17873885 11498787 27454289 11927591 24981860 25652403 25634209
PALB2 BRCA2 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 19609323 7262167
BRCA2 RAD51 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 9405383 19875419 23935068 14580352 9774970 15937124 11239456 21076401 10551859 16513631 21601571 25585578 12815053 16793542 11477095 26833090 21670257 26145171 18264088 15713648 9811893 12941707 25282148 20729832 26387543 24835992 18429819 15800651 17515903 21399666 18317453 22116401 11313963 33476590 14636569 15897881 15800615 10373512 9523196 9126738 27941124 17541404 12442171 9560268 20729859 12619154 16914443 28765325 17515904 31113933 28757209 15065660 19303847 28168276 19628690 12606939 24013206 24981860 20871615 15671039 22293751 21789034
IRS1 GRB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 7488107 8388384 7486683 8810325 22974441 21706016 8491186 7629070 12173038 8536716
BCR GRB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 8112292 11726515 15143164 9747873 10887132 8995379 8955135 9174058 14725908 21706016 33961781 19380743 32203420 9178913 7529874
NBN MDC1 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 20224574 7891431
H2AX MDC1 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 6805208 18583988
KEAP1 SQSTM1 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
RPA1 TP53 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
BRCC3 BRE â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
MAP2K1 MAPK1 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
FANCM RPA1 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
RAD51 BRCA2 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 5219969 17541404
TP53 EP300 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 16611888 6599495
CSNK2B CSNK2A1 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 36833176
CASP8 FADD â—¼   COLOCALIZATION ✅ 0.98 0.98 mint 5219431 17159907
BLM RPA1 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
BRCA1 RBBP8 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
BRCA2 PALB2 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
RPA1 RPA3 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
CREBBP TP53 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
TP53 TP53BP1 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
MAP2K2 MAPK1 â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
TUBG1 TUBGCP2 â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
MSH6 MSH2 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 19377479 25241761 10783165 8942985 9428522 10029069 26496610 10856833 14657349 10748159 33961781 9774676 22939629 26344197 15064730
FADD CASP8 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 21785459 23142077 21988832 23972990 17290218 24098568 14681455 20103630 33469115 18485876 22274400 22864571 25043603 27560715 25939870 29795330 19524512 17159907 30561431 27552911 19176810 15659383 9343261 22179575 22173242 25911380 27321185 8681376 15280356 21737330 26437781 31046799 21458669 12702723 11717445 21737329 19060883 21525013 23429285 20448643 12107169 17047155 9228018 12887920 29497034 12911633 14612908 23955153 33961781 20829884 26972597 21620750
BLM RAD51 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
FANCL FANCM â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
GNB3 GNG12 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB3 GNG3 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
BRAF MAP2K1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
TOPBP1 TP53BP1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
RPA1 RPA2 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
BARD1 BRCA1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EP300 TP53 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
FANCM RMI1 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
WRN ATM â—¼   PHYSICAL_INTERACTION 51.0 1.0 ACSN 11283614 11331603 11850621 11877377 12202749 12607003 15140942 15211575 15385537 15459660 15498778 15964794 16163361 16449207 17055429 17116323 17303408 17965729 18087292 18171986 18398454 18524993 18558713 18584027 18809224 19202191 19362533 19490890 19654615 19772495 19793801 19892829 20027199 20064462 20691907 20713526 20723763 21376743 2191300 22657828 22743550 23082994 23161013 23253856 23847781 24036544 24050180 24089143 24095737 24709898 9721205
H2AX ATM â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11934988 15279782 12792649 11893489 10959836
BRCA1 ATM â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
BLM ATM â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
DNA2 ATM â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
ATM BARD1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
ATM MDC1 â—¼   PHYSICAL_INTERACTION 64.0 1.0 ACSN 11331603 11571274 11850621 11877377 12086603 12234250 12556884 12607003 14614141 14988723 15136767 15140942 15175241 15242590 15279786 15375219 15377654 15459660 15485915 15798197 15964794 16163361 16332722 16531125 16713580 16805667 16818604 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17660363 18001824 18006705 18087292 18469862 18543256 18583988 18584027 18590585 18678890 18809224 18995830 19151707 19282663 19342888 19622404 19686080 19772495 19793801 20051983 20160076 20723763 21376743 22743550 23030059 23847781 24050180 7575488 9407949 9488723
ATM UIMC1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 18077395 17525340 18001825 18001824 18006705
ATM ABRAXAS1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 18077395 17525340 18001825 18001824 18006705
ATM RMI1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
WRN ATM â—¼   SHARES_COMPLEX 51.0 1.0 ACSN 11283614 11331603 11850621 11877377 12202749 12607003 15140942 15211575 15385537 15459660 15498778 15964794 16163361 16449207 17055429 17116323 17303408 17965729 18087292 18171986 18398454 18524993 18558713 18584027 18809224 19202191 19362533 19490890 19654615 19772495 19793801 19892829 20027199 20064462 20691907 20713526 20723763 21376743 2191300 22657828 22743550 23082994 23161013 23253856 23847781 24036544 24050180 24089143 24095737 24709898 9721205
ATM MDC1 â—¼   SHARES_COMPLEX 64.0 1.0 ACSN 11331603 11571274 11850621 11877377 12086603 12234250 12556884 12607003 14614141 14988723 15136767 15140942 15175241 15242590 15279786 15375219 15377654 15459660 15485915 15798197 15964794 16163361 16332722 16531125 16713580 16805667 16818604 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17660363 18001824 18006705 18087292 18469862 18543256 18583988 18584027 18590585 18678890 18809224 18995830 19151707 19282663 19342888 19622404 19686080 19772495 19793801 20051983 20160076 20723763 21376743 22743550 23030059 23847781 24050180 7575488 9407949 9488723
CDK5 ATM â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 12556884 16332722 16858402 17303408 19151707 20724832 21727086 21922195 23589330 23850759
ATM RPA2 â—¼   ENZYMATIC_REACTION ✅ 54.0 1.0 ACSN 11331603 11438669 11804596 11877377 12086603 12556884 12607003 14988723 15136767 15140942 15175241 15459660 15485915 15798197 15867354 15964794 16163361 16332722 16581787 16713580 16731533 16805667 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17713585 18006705 18048416 18469862 18511906 18583988 18716619 18756267 18995830 19151707 19282663 19342888 19357644 19490890 19622404 19788416 19793801 19793861 19841479 20019063 20051983 21376743 23847781 9168117 9858600
ATM BRCA1 â—¼   ENZYMATIC_REACTION ✅ 54.0 1.0 ACSN 11331603 11438669 11804596 11877377 12086603 12556884 12607003 14988723 15136767 15140942 15175241 15459660 15485915 15798197 15867354 15964794 16163361 16332722 16581787 16713580 16731533 16805667 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17713585 18006705 18048416 18469862 18511906 18583988 18716619 18756267 18995830 19151707 19282663 19342888 19357644 19490890 19622404 19788416 19793801 19793861 19841479 20019063 20051983 21376743 23847781 9168117 9858600
ATM CHEK1 â—¼   ENZYMATIC_REACTION ✅ 54.0 1.0 ACSN 11331603 11438669 11804596 11877377 12086603 12556884 12607003 14988723 15136767 15140942 15175241 15459660 15485915 15798197 15867354 15964794 16163361 16332722 16581787 16713580 16731533 16805667 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17713585 18006705 18048416 18469862 18511906 18583988 18716619 18756267 18995830 19151707 19282663 19342888 19357644 19490890 19622404 19788416 19793801 19793861 19841479 20019063 20051983 21376743 23847781 9168117 9858600
ATM MDC1 â—¼   ENZYMATIC_REACTION ✅ 64.0 1.0 ACSN 11331603 11571274 11850621 11877377 12086603 12234250 12556884 12607003 14614141 14988723 15136767 15140942 15175241 15242590 15279786 15375219 15377654 15459660 15485915 15798197 15964794 16163361 16332722 16531125 16713580 16805667 16818604 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17660363 18001824 18006705 18087292 18469862 18543256 18583988 18584027 18590585 18678890 18809224 18995830 19151707 19282663 19342888 19622404 19686080 19772495 19793801 20051983 20160076 20723763 21376743 22743550 23030059 23847781 24050180 7575488 9407949 9488723
MSH2 ATM â—¼   UP_REGULATES ✅ + 20.0 1.0 ACSN 12556884 12947387 15136767 15703371 16332722 16612326 16697054 16713580 16858402 17303408 18157157 18406444 18543256 19151707 19473888 19595721 19596235 19596236 19847258 20478261
MSH6 ATM â—¼   UP_REGULATES ✅ + 20.0 1.0 ACSN 12556884 12947387 15136767 15703371 16332722 16612326 16697054 16713580 16858402 17303408 18157157 18406444 18543256 19151707 19473888 19595721 19596235 19596236 19847258 20478261
ATM MDC1 â—¼   REGULATES ✅ 64.0 1.0 ACSN 11331603 11571274 11850621 11877377 12086603 12234250 12556884 12607003 14614141 14988723 15136767 15140942 15175241 15242590 15279786 15375219 15377654 15459660 15485915 15798197 15964794 16163361 16332722 16531125 16713580 16805667 16818604 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17660363 18001824 18006705 18087292 18469862 18543256 18583988 18584027 18590585 18678890 18809224 18995830 19151707 19282663 19342888 19622404 19686080 19772495 19793801 20051983 20160076 20723763 21376743 22743550 23030059 23847781 24050180 7575488 9407949 9488723
CDK5 ATM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 17303408 23589330 16858402 19151707 27470939 16332722 12556884 21600237 21922195
ATM SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 23148884 18619531 22826432 27156884 29144413 29294106 23046908 17609267 18171990
ATM RPA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 29875999 15964794 11877377 17303408 9725899 16163361 14872059 23847781 9139719 10713094 9295339 20860841 16731533 12607003 22977173 7171818 15459660
ATM E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 20972224 11459832 27679857 15494392 15140942 27028861 21543892 27025900 20860841 24741006 17570479 25101673 28812991 15838517 22174788
ATM EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 20471956 15494392 15140942 29590107 26170237 21108945 15838517 27220480
ATM TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 452.0 1.0 Omnipath 25301947 21720806 23549171 10713094 16501611 15077171 24886358 17570479 19375142 22028490 16916644 14712210 19303885 9407038 11927276 26700820 28356518 15226429 10723129 19788889 12064478 19705844 26673821 22179422 20931131 19062161 27030982 22891162 17157788 19056039 15758953 12049739 15361830 26620371 25865756 22615843 10196661 10656682 11313957 25088203 15140942 12519769 16319535 24469230 12776195 17234789 27511909 29238697 24608431 12927814 16783362 11875057 16436515 22778557 15181149 12702572 10500142 15178764 28842590 28145533 11591448 17855337 22726545 20206688 26824362 21317290 26104798 24704793 9765199 11314044 16906133 17174997 21593792 17967874 10771484 15585169 19625493 15178448 17596534 16288207 15048074 18353733 24057508 19535302 29344296 23708100 29872395 23705030 25043304 33761896 18431490 21404020 15024084 22559321 12151394 24078877 12080066 33982778 16893723 10958792 18289945 27183917 26337656 29170437 18765533 10744722 21748595 18056442 24820418 15489892 16390936 24086335 28140789 23091651 34523970 32001619 23418564 15279808 21317932 21188172 27559048 16818505 17616578 11551930 19010925 11709713 24711418 28654064 18339864 11173129 17486112 10570149 29774100 18381438 21994612 29558908 15258567 9372954 25860929 16858402 33692124 15775976 34107253 19923893 24958101 10436023 14752509 19962312 19071090 26438152 26093282 20123963 22444248 9843217 17525332 15456784 23533526 11780126 20353948 29290977 11096068 28102346 18855897 20372057 24395704 23890999 15725625 15806145 34103468 18345031 16997395 16293623 28477117 19828454 27630139 12071847 22002314 21315088 27177180 12645530 12890678 26113041 15794754 18560558 22099307 9885574 28903382 15665826 24877058 18332866 10611322 24380814 14871840 19934315 22975381 16489034 18406507 21440540 33687951 10608806 23892398 20730097 16914171 15782130 15177184 22055193 18490454 25867001 24349352 18045533 20663147 17535811 20506250 23982736 22375140 15700044 15279774 19266268 24358288 18697815 14729946 20637859 12242661 12771937 17371838 31940492 19409520 10528155 24037342 17257427 11121242 15310764 23148227 28915641 26928575 21423215 11865061 16949371 27810895 18449195 20711232 27389279 22213803 16713569 10446957 22797063 16478990 29048667 15489221 17241873 21187893 21441950 23907539 20005840 9733514 26244501 21614094 12082529 10467728 10714958 32061892 16636671 29147215 10673501 12091386 25202122 21465263 19544417 25823026 24078903 24038750 22198295 21480565 15177039 28182994 28208785 18674635 20183804 18818083 9925639 17712528 15254178 11483158 27940348 26675349 26261212 19717643 12606585 24559687 14871926 23150668 21329876 28153791 12518062 12767922 23824039 11711532 19251701 28118604 15078887 12393500 17456577 20976220 23380594 12519780 20810927 15533933 22420423 17108107 20145032 18032786 18785202 22037398 23184057 31968249 16729035 12588868 21614932 11546806 18614045 14757188 15029243 14968111 22649771 25512053 34496248 18604166 17609585 17976513 16223874 25433195 18985806 9363941 15159397 34282274 29301278 24505404 26056062 23577291 18272544 18715874 19536869 29334356 10801407 15155458 25201202 24376853 19907922 23525106 14643431 28340339 28051100 19085961 15212693 22201816 20026654 16322229 20080565 9733515 15632067 18672098 22577550 25691451 12637545 12548019 11672523 26984736 12324477 16552184 22084686 10864201 14744854 21532626 17118344 19482562 9561848 12511424 17668048 23358251 18511169 21460853 22022355 12939400 21415014 17292432 25651062 23168260 12111733 16648554 30361254 23678107
ATM NBN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 80.0 1.0 Omnipath 12433983 12861053 17485521 23146902 10839545 19413330 15302935 27602502 17429352 19523210 24360018 20068231 17507690 17570479 10608806 12598907 18669648 25088203 18003706 11252893 17431132 23097684 10766245 12814430 10802669 21664921 26512707 10839544 11927276 21130714 17525332 12447395 14707289 15733840 15279770 25119968 18644472 28822740
ATM TP53BP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 34.0 1.0 Omnipath 11042216 17940005 26247731 18996087 19876065 16945145 12447390 22621922 18644834 19650866 24320053 18077418 17570479 17690115 17525332 12697768
ATM TOPBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 11756551 18077418 19279141 17525332 17446169
ATM RPA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17525332 11359916
ATM BLM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 16199871 11146546 25766002 17984114 14643436 20719863 17363339 14729972 18054789 12034743 30496191 16880735 11375976
ATM NABP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 25249620 26170237 28448822 21051358 18449195 23178594
ATM RBBP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 26.0 1.0 Omnipath 23468639 23675572 17570479 24837676 10910365 16249056 11689934 10608806 17525332 22743550
ATM CHEK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 69.0 1.0 Omnipath 29774099 20976184 26683224 25663895 12676583 17303408 14657349 29167438 27545311 10859164 19056039 15485915 28808226 12588868 16163361 15650047 12676962 17570479 14988723 14681223 26516160 10608806 26069190 29741650 12676925 23847781 17118344 11252893 20376879 15964794 15149599 18691976 19059218 20068082 15707391 12607003 25450480 17525332 11553781 19646247 15870257 15459660 20798862 19716789 11877377 12660173 11390642 15674326 16782033 28396830 28228262 12446774 15533933 15212693 29555944
ATM MCM3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15210935 17244605 30062004
ATM H2AX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 197.0 1.0 Omnipath 27410735 28544233 16426903 28797244 9488723 23847653 30197789 21930799 18158901 21693595 18848500 22819196 15603757 16760673 17570479 24688021 24793032 27458206 16531125 22028490 30154456 19230794 23202908 25852739 19059218 26073471 22247744 28259974 29584802 25691887 19049966 20368801 26700820 29386061 28124509 20613862 27550454 20847938 27388041 27752097 23269287 24480460 22237206 20461094 20971043 26941327 18285803 21690091 15279774 23891287 25847270 24490130 25349305 26906421 20637859 26314960 15286739 27780918 20454618 30013081 28671946 25218945 23742011 26391293 23972723 23382699 26416514 27442013 20703100 24726884 26512707 27332952 29641431 25287622 26295265 14643438 29163809 25264544 19895790 26504743 26113859 27431324 28790385 18413980 21283714 21787120 20205745 19781914 25093845 27135971 23227178 22224778 20923785 20860841 24244154 23386996 30065307 16858402 11879731 28009280 23343929 20192759 22761798 26855420 24378750 20068231 20580718 14504478 24893124 29048667 25661368 26860083 26019182 20488183 28764946 22205726 23977391 18471973 19591958 28239143 20542002 17525332 20495376 18755145 23050241 17782711 11571274 19473884 28431265 25742493 18248856 17690115 20684759 26317467 21727091 24651472 25827888 27164092 28587922 20976184 30723510 20471486 23772364 29794999 11893489 19014481 20165693 26671524 16997395 20936109 26114388 23845989 15138496 22761813 23355489 27455285 28943310 21348461 19647519 23678292 23166506 28099474 29434792 25249630 25269479 27310012 15177039 22559321 26045162 20865059 22972376 21148072 26760771 21188122 22962268 22768044 26711340 20460517 27845910 28855246
ATM BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 79.0 1.0 Omnipath 26927092 17303408 15159397 24746700 12024016 10866324 30197789 12919958 11114888 26745677 26383678 34301763 12427729 11313470 16163361 28035057 20068231 25939603 26320175 17570479 19683496 22743550 10608806 23802008 23847781 21203981 15964794 12183412 12607003 17525332 19996295 15459660 11278964 19651622 21706030 11877377 20952512 10373534 19622773 10550055 27170701 15212693 23704879
ATM ABRAXAS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17525332 17525340 26778126
ATM MDC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 17145710 28193847 21705321 22234877 12607003 12607005 22234878 17525332 18006705
E2F1 BCL2L11 â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 11050388 11301023 11495903 14684737 15279786 17218262 17303408 17604722 17660363 18281283 18590585 19494111 7575488
MAPK1 BCL2L11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 15486195 17604722 14555991 28474232 19150432 12646560 16282323 12818176 17570479 15486085 15212693
E2F1 BCL2L11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17604722 11495903 11301023 18319725 19494111 11050388 18281283 14684737
NBN BLM â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
BRCA1 BLM â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
BLM FANCL â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 8020957
BLM RMI1 â—¼   PHYSICAL_INTERACTION 26.0 1.0 ACSN 15496928 15549137 15655342 16537486 16595695 16697054 18001825 18171670 18212739 18931676 19217833 19270065 19490890 19622404 19686080 19772495 19847258 19945966 20021983 20064462 20826342 22266823 22657828 23253856 24089143 24095737
BLM BARD1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
BLM FANCM â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 8020957
BLM FANCM â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 8020957
BLM RMI1 â—¼   SHARES_COMPLEX 26.0 1.0 ACSN 15496928 15549137 15655342 16537486 16595695 16697054 18001825 18171670 18212739 18931676 19217833 19270065 19490890 19622404 19686080 19772495 19847258 19945966 20021983 20064462 20826342 22266823 22657828 23253856 24089143 24095737
BLM FANCL â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 8020957
BLM WRN â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 16697054 18931676 19622404 19686080 19772495 19847258 22266823 22657828 22973052 23253856 24089143 24095737
BLM FEN1 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 16697054 18931676 19622404 19686080 19772495 19847258 22266823 22657828 22973052 23253856 24089143 24095737
FANCM BLM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 20347428 20064461
RMI1 BLM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17145710 15775963 23509288
CHEK1 BLM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 21050475 20719863 25015292 25906194 15364958
BLM TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 12080066 11399766 22653443 24239288 15806145 11781842 16713569 15364958
BLM FEN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 17145710 19772495 18931676 19847258 22266823 12356323 19622404 16326861 24089143 22973052 23253856 22657828 16697054 24095737 19686080 14688284
NBN BRCA1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
BRCA1 BARD1 â—¼   PHYSICAL_INTERACTION 36.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19342239 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
BRCA1 BRCA2 â—¼   PHYSICAL_INTERACTION 69.0 1.0 ACSN 10858305 10931916 11571269 11756412 11850621 11877377 11927554 12239151 12551922 12607003 12947387 14624239 14726013 15220350 15459660 15590677 15650050 15703371 16337601 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18448394 18472307 18584027 18660752 18809224 18931676 19075014 19217432 19264559 19473888 19525936 19622404 19686080 1974050 19759212 19772495 19793801 19793861 19793862 19841479 19847258 19995904 20029420 20081207 20173781 20376879 20723763 20813759 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BRCA1 E2F1 â—¼   PHYSICAL_INTERACTION 24.0 1.0 ACSN 10884389 11877377 12496474 15175241 15220350 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 18660752 19525936 19793801 20029420 20376879 21060331 21337561 24254977 7575488 7935440
BRCA1 RMI1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
BRCA1 UIMC1 â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 11877377 15459660 16697054 19342239 19772495 19793801 19847258 20029420 21060331 21337561
BRCA1 XRCC3 â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
BRCA1 RAD51 â—¼   PHYSICAL_INTERACTION 64.0 1.0 ACSN 10858305 10931916 11571269 11756412 11850621 11877377 11927554 12239151 12551922 12607003 12947387 14624239 14726013 15220350 15459660 15590677 15650050 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18660752 18809224 18931676 19075014 19217432 19264559 19473888 19525936 19622404 19686080 1974050 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BRCA1 BRCC3 â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 11877377 15459660 16697054 19342239 19772495 19793801 19847258 20029420 21060331 21337561
BRCA1 DNA2 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
BRCA1 UIMC1 â—¼   SHARES_COMPLEX 10.0 1.0 ACSN 11877377 15459660 16697054 19342239 19772495 19793801 19847258 20029420 21060331 21337561
BRCA1 E2F1 â—¼   SHARES_COMPLEX 24.0 1.0 ACSN 10884389 11877377 12496474 15175241 15220350 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 18660752 19525936 19793801 20029420 20376879 21060331 21337561 24254977 7575488 7935440
BRCA1 BRCC3 â—¼   SHARES_COMPLEX 10.0 1.0 ACSN 11877377 15459660 16697054 19342239 19772495 19793801 19847258 20029420 21060331 21337561
BRCA1 BARD1 â—¼   SHARES_COMPLEX 36.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19342239 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
BRCA1 BRCA2 â—¼   SHARES_COMPLEX 69.0 1.0 ACSN 10858305 10931916 11571269 11756412 11850621 11877377 11927554 12239151 12551922 12607003 12947387 14624239 14726013 15220350 15459660 15590677 15650050 15703371 16337601 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18448394 18472307 18584027 18660752 18809224 18931676 19075014 19217432 19264559 19473888 19525936 19622404 19686080 1974050 19759212 19772495 19793801 19793861 19793862 19841479 19847258 19995904 20029420 20081207 20173781 20376879 20723763 20813759 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BRCA1 RAD51 â—¼   SHARES_COMPLEX 64.0 1.0 ACSN 10858305 10931916 11571269 11756412 11850621 11877377 11927554 12239151 12551922 12607003 12947387 14624239 14726013 15220350 15459660 15590677 15650050 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18660752 18809224 18931676 19075014 19217432 19264559 19473888 19525936 19622404 19686080 1974050 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BRCA1 XRCC3 â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
TP53BP1 BRCA1 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11042216 11877378 17243194 18087291 19342239 20646866 9748285
BRCA1 E2F1 â—¼   ENZYMATIC_REACTION ✅ 24.0 1.0 ACSN 10884389 11877377 12496474 15175241 15220350 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 18660752 19525936 19793801 20029420 20376879 21060331 21337561 24254977 7575488 7935440
BRCA1 DDB2 â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 10367887 10779360 10962562 11877377 12024039 12170778 12496474 12771027 15242590 15459660 15485915 16818604 19004803 19357644 19686080 19788416 19793801 20029420 21060331 21337561 9346961 9892649
BRCA1 DNA2 â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 11877377 15459660 18087291 19342239 19793801 20029420 21060331 21337561
MDC1 BRCA1 â—¼   DOWN_REGULATES ✅ - 13.0 1.0 ACSN 12607003 15279786 15459660 17303408 17660363 18001824 18006705 18087291 18583988 18590585 18678890 7575488 9407949
BRCA1 CHEK1 â—¼   REGULATES ✅ 22.0 1.0 ACSN 10367887 10779360 10962562 11877377 12024039 12170778 12496474 12771027 15242590 15459660 15485915 16818604 19004803 19357644 19686080 19788416 19793801 20029420 21060331 21337561 9346961 9892649
SP1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15252835 17373631 18377656 19466541
CTBP1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20818429 21681822 23303449
E2F1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 10660629 23285190 18660752 19466541 17106239 20068145 23108140
TP53 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 24.0 1.0 Omnipath 9582019 11295099 18625847 11003642 12802282 16357511 14710355 9619832 19882681 10884389 11384963 11782367 12024039 15735697 12170778 21245169 17993233 12549011 11431698 16229810 18208621 10597265 21742769
UIMC1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17525341 17525342 17525340 17621610
BARD1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 99.0 1.0 Omnipath 16403807 16391231 28262780 15159397 25652403 26350354 26490435 14647430 11927591 25184681 16713569 11526114 35203293 9738006 12732733 24289923 11573085 18936166 23086937 24085845 12890688 15855157 24695549 19369211 9798686 11257228 11498787 12700228 11925436 10477523 19176389 23680151 25634209 23416467 34726323 29355525 18369654 14636569 11504724 12951069 19117993 20060929 17873885 14638690 18493658 11278247 15184379 22110403 11301010 11773071 12431996 10635334 20029420 9788437 17664283 21901007 25252691 12485996 10026184 12438698 17525341 16489000 8944023 15265711 12419249 20681793 9342365 27239795 20215511 25823446 19916563
ABRAXAS1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 17643122 19261749 22357538 17525340 19261746 21282113 19261748 25184681 17643121 19305427 23416467
E2F1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9244350 18660752 18319725 11278247 12697828 16713569 12909625
MDC1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 18087291 17525332 12607005
BRCA1 RBBP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 21908405 18285836 16713569 15485915 25310973 9738006 17525342 17525340 16843262 24085845 25184681 26387952 18369654 9811458 16818604 20351172 23416467 19442256 10196224 10910365 19452558 11739404 25252691 10764811 25659039 17965729 11689934
BRCA1 PALB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 26649820 19268590 28089683 28319063 19369211
BRCA1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 11244506 12400015 15674350 10334989 16713569 11493692
BRCA1 H2AX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18001824 18001825 17145710 12419185
BRCA2 RAD51 â—¼   PHYSICAL_INTERACTION 64.0 1.0 ACSN 10858305 10931916 11571269 11756412 11850621 11877377 11927554 12239151 12551922 12607003 12947387 14624239 14726013 15220350 15459660 15590677 15650050 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18660752 18809224 18931676 19075014 19217432 19264559 19473888 19525936 19622404 19686080 1974050 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BRCA2 BARD1 â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
BRCA2 XRCC3 â—¼   PHYSICAL_INTERACTION 48.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15496928 15549137 15590677 15650050 15655342 16337602 16697054 17349954 18001825 18171670 18212739 18660752 18931676 19217833 19270065 19473888 19490890 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20021983 20029420 20064462 20081207 20376879 20723763 20813759 21060331 21337561 22266823 22505525 22751496 22771115 23444773
BRCA2 RAD51 â—¼   SHARES_COMPLEX 64.0 1.0 ACSN 10858305 10931916 11571269 11756412 11850621 11877377 11927554 12239151 12551922 12607003 12947387 14624239 14726013 15220350 15459660 15590677 15650050 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18660752 18809224 18931676 19075014 19217432 19264559 19473888 19525936 19622404 19686080 1974050 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 9488723
BRCA2 BARD1 â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
BRCA2 XRCC3 â—¼   SHARES_COMPLEX 48.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15496928 15549137 15590677 15650050 15655342 16337602 16697054 17349954 18001825 18171670 18212739 18660752 18931676 19217833 19270065 19473888 19490890 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20021983 20029420 20064462 20081207 20376879 20723763 20813759 21060331 21337561 22266823 22505525 22751496 22771115 23444773
TP53 BRCA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 9619832 11295099 18765668 12591928
PALB2 BRCA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 17420451 16793542 26990772 19268590 22293751 17488615 19369211 23585894 24485656 20332121 24141787 26649820 19553677 17200672 26833090 23038782 17200668 15115758 19609323 30410870 19584259 22193777
PLK1 BRCA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 32286328 12815053
BRCA2 RAD51 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 87.0 1.0 Omnipath 17145710 21601571 15937124 17541404 11313963 16914443 26145171 21670257 18264088 19303847 25585578 12815053 16793542 21789034 25282148 17515904 9126738 20729859 15703751 21076401 15065660 22293751 19875419 12606939 22116401 12619154 23935068 15800615 33476590 15800651 15671039 11477095 16513631 9811893 10551859 20729832 9523196 14636569 17515903 12442171 9405383 26833090 21399666 19628690 9560268 10373512 14580352
BARD1 BRCC3 â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 11877377 15459660 16697054 19342239 19772495 19793801 19847258 20029420 21060331 21337561
BRCC3 UIMC1 â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 11877377 15459660 16697054 19342239 19772495 19793801 19847258 20029420 21060331 21337561
BARD1 BRCC3 â—¼   SHARES_COMPLEX 10.0 1.0 ACSN 11877377 15459660 16697054 19342239 19772495 19793801 19847258 20029420 21060331 21337561
BRCC3 UIMC1 â—¼   SHARES_COMPLEX 10.0 1.0 ACSN 11877377 15459660 16697054 19342239 19772495 19793801 19847258 20029420 21060331 21337561
BRCC3 TP53BP1 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11042216 11877378 17243194 18087291 19342239 20646866 9748285
TP53 CASP3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 22154326 22178888 23677569 15578696 17363498 24098340 18064040 23527225 10893263 21859835
BIRC7 CASP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 23563149 11024045 17145710 11084335
E2F1 CASP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18660752 12389032 18319725
CASP8 CASP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 15755874 17179148 9501089 9950028 18669646 23308069 10988287 18458084 16964285 9885230 9765224 11437602 15014070 21295084 8962078 9208847
CASP3 RAD51 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 10998058 10082566 11684015
CASP3 STK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11278782 11278283 11517310 9545236
RELA CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 17673602 18226221 10464245 18566231 19800042 18174238 15755876 18341653 11861406 20103608 12894581 17098279 22306268 20922712 16998474 10409765 19766095 15756023 21056029 22835384 17407600 15870875 18184402 17944672 15856023 20538607 19263436 16453001
SP1 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 10497251 22911796 19850937 9236224 17617380 9407106 15870300 22415074 10850422 9584162 10908361 22734486 16267018 9637785 19755513 11410592 11024050 15922873 12794082 20435036 22334592
ESR1 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 11477579 12554765 12808053 17166846 22892083 21505052 18414489 9832502 23864650 22396492 22266855 11358796 23891847 22948256 11986316 15282324 15496458 22521644 14764652 15178330 23108396 11410592 15026472 17998543 17681750 18245487 20821348 16860316 11844790 19858209 12929585 15808510 18997820 15217513 16809759 10500157 16980581 17914104
TP53 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 24189068 8702807 10669755 22270849 12808109 17942917 19086036 20731879 16061648 20554748 24460719 11798189 10082575 15205322 18769160 19800042
E2F1 CCND1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 10504464 7929342 22768064 19876926 20220142 9584162 17998543 20655656 8618861 8137237 23078099 23543735 10594784
EP300 CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 17306568 17666529 11788592 23343194 21285352 15576399 21151179 22761862 22290435 16039586 19619488 19623618 17143292
CTBP1 CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 17666529 23343194 21285352 18974774 22761862 22290435 16039586 19619488 19623618 17143292
MAX CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 8425218 15121849 2006410 17873522 21406394 12584560 17558397 20551172 15814658 16908182
ESR1 CCND1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8649771 11073968 16061635 9039267
CCND1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 9190208 10498883 18590585 7575488 9315635 17303408 10385618 10778858 9736735 16236519 20068082 7736585 9425340 11520855 19075565 18786381 17660363 15279786
TOPBP1 CHEK1 â—¼   PHYSICAL_INTERACTION 52.0 1.0 ACSN 11756412 11877377 12086603 12466554 12766152 12875843 14624239 14657033 14726013 14988723 15136767 15175241 15189446 15459660 15485915 15703371 15798197 16530042 16697054 16713580 16805667 16880517 16885023 16934469 17035102 17102137 17116885 17141802 17296725 17303408 17384638 17582221 18157158 18451105 18469862 18677104 18931676 18995830 19158510 19217833 19225445 19258535 19282663 19342888 19622404 19686080 1974050 19793801 19847258 20051983 22021614 23414611
CHEK1 RPA2 â—¼   PHYSICAL_INTERACTION 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
CHEK1 RPA3 â—¼   PHYSICAL_INTERACTION 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
CHEK1 RPA1 â—¼   PHYSICAL_INTERACTION 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
CHEK1 MCM3 â—¼   PHYSICAL_INTERACTION 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
TOPBP1 CHEK1 â—¼   SHARES_COMPLEX 52.0 1.0 ACSN 11756412 11877377 12086603 12466554 12766152 12875843 14624239 14657033 14726013 14988723 15136767 15175241 15189446 15459660 15485915 15703371 15798197 16530042 16697054 16713580 16805667 16880517 16885023 16934469 17035102 17102137 17116885 17141802 17296725 17303408 17384638 17582221 18157158 18451105 18469862 18677104 18931676 18995830 19158510 19217833 19225445 19258535 19282663 19342888 19622404 19686080 1974050 19793801 19847258 20051983 22021614 23414611
TOPBP1 CHEK1 â—¼   ENZYMATIC_REACTION ✅ 52.0 1.0 ACSN 11756412 11877377 12086603 12466554 12766152 12875843 14624239 14657033 14726013 14988723 15136767 15175241 15189446 15459660 15485915 15703371 15798197 16530042 16697054 16713580 16805667 16880517 16885023 16934469 17035102 17102137 17116885 17141802 17296725 17303408 17384638 17582221 18157158 18451105 18469862 18677104 18931676 18995830 19158510 19217833 19225445 19258535 19282663 19342888 19622404 19686080 1974050 19793801 19847258 20051983 22021614 23414611
E2F1 CHEK1 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 10884389 12496474 15220350 15279786 17218262 17303408 17660363 18590585 18660752 19525936 20376879 7575488
CHEK1 RPA2 â—¼   DOWN_REGULATES ✅ - 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
CHEK1 RPA1 â—¼   DOWN_REGULATES ✅ - 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
CHEK1 RPA3 â—¼   DOWN_REGULATES ✅ - 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
CHEK1 MCM3 â—¼   DOWN_REGULATES ✅ - 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
CHEK1 MCM3 â—¼   REGULATES ✅ 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
CHEK1 RPA3 â—¼   REGULATES ✅ 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
CHEK1 RPA2 â—¼   REGULATES ✅ 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
CHEK1 RPA1 â—¼   REGULATES ✅ 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
TP53 CHEK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 21546904 11158294 20190799 19435816 18632613 15016801 19395378 11152453 18753293
E2F1 CHEK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 7575488 18590585 20376879 17303408 18660752 19525936 17660363 15220350 15279786
CHEK1 RAD51 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 26610585 27685627 18285803 22730303 18317453 22705496 29977027 19473886 22665067 25852742 25909291 24847116 24204313 15665856 24238855
CHEK1 TP73 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 22084676 18524021 23508805 14585975
CHEK1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 64.0 1.0 Omnipath 20950777 18778462 25545885 18677104 20860841 15798197 19793801 22891162 16511572 23852422 16713569 15865930 11551930 19923893 15467443 11709713 21748595 17116885 15659650 17582221 26384650 10673501 17384638 23966620 23892398 17118344 9765199 15140942 19788416 10801407 18319725 12781359 12897801 25823026 15459660 23296650 15024084 17296725 17102137 11896572 17339337 19933256 20526329 28140789
TP53 DDB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12771027 22336944 15856024 12509284 12170778 16357511 12967652 15927209 11971958
E2F1 DDB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9418871 19376752 17173070
NBN DNA2 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
DNA2 BARD1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
E2F1 PMAIP1 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 12676992 14684737 14699081 15279786 16888645 17218262 17303408 17660363 18590585 7575488
E2F1 RAD51 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 15279786 17218262 17303408 17660363 18590585 7575488
TP53 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 21715977 20805247 8557038 11795482 17210690 22952705
ESR1 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22791811 20215421 12697671 10446910
SP1 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9054613 12697671 10446910 18440323
E2F1 CCNE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 21653699 19564413 20220142 23518498 8668155 7623816 1059478 14618416 20410059 12565705 17471231 23543735 10594784 24335704 22185819 21454377 11526499 10504464 8618861 8649818
E2F1 RAD51 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16398215 23285190 17218262 12629508
E2F1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 22241525 8557038 15706352 21441950 12675512 23954287 12625370
E2F1 TP73 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 12766778 11101847 11988839 14602923 18660752 19188449 18029729 18521084 15210709 11115495 17980704 19363520 12789260 21310950 22952705
TOPBP1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 20413589 18660752 14576433 17006541 12697828 14576432
CCNE1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 7575488 18590585 18687693 9315635 17303408 17660363 12006580 11420722 15279786
CREBBP E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10753885 15126619 12748276 15123636 8932363
MCPH1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23697381 18660752 23001041
E2F1 PMAIP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12676992 18319725 14699081 16888645 14684737
E2F1 TP73 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15210709 11988839 17488475 11937641
E2F1 RAD51 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15766563 22699938 17218262
E2F1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22480684 11739724 12625370
PRKAA1 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 11020388 21940946 12379484 15006641 12590608
MAPK1 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17623675 24530506
EP300 MITF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9660747
EP300 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 19608861 25400040 11567019 12419806 17617622 11533489 20333651 12456660 15152190 16846590 9096323 20064247 16382138 16713569 15171256 16135789
EP300 FEN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 19608861 11430825
EP300 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 137.0 1.0 Omnipath 11907332 25545885 21187340 10706102 16438982 10490106 19339993 15542844 23010591 11433299 19608861 17438265 17906639 16024799 9194564 20234175 23402884 12162806 26229107 16959611 15186775 9744860 11070080 17977830 17189186 22266186 20228809 15664194 19805293 25753752 11804596 26625199 27818144 10648616 16928824 9288740 10942770 12724314 23148227 23728348 15965232 19218448 16678111 16782091 20094059 14612423 24821727 10518217 16713569 9891054 25288747 17452980 14759370 19788416 25156994 18931695 22074660 23880760 15337767 15509808 26302407 22731250 18391200 16543236 19234109 21471221 23307557 25867071 12690203 15558054 18612383 23870121 18243116 19217391 22013068 16537920 16611888 18485870 9194565 12660246 9809062 23796514 11359905 12501250 15295102 19407812 25651062 23329847 16135789
EP300 TP73 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 11804596 19407812 15175157 19788416 12660246 19218448 10648616 15454570 16998810 25675294 15893728 18663001
EP300 NBN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 20471956 16051665 21108945
ERCC5 ERCC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8652557 16713569 20840796
RPA2 ERCC5 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 17000769 9699634 7700386 15590680 9716411 17466625
RPA1 ERCC5 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 17000769 9699634 7700386 15590680 9716411 17466625
ERCC5 RPA3 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 17000769 9699634 7700386 15590680 9716411 17466625
ACTB EVL â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 12805219 18001770 12732141 12429848 18923426
FANCM FANCL â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 8020957
FANCM FANCL â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 12239151 12466554 12535671 12972610 14657033 14988723 15136767 15189446 16337602 16697054 17035102 18157158 18448394 18469862 18472307 18550849 18931676 19217833 19225445 19258535 19282663 19622404 19686080 19772495 19847258 20832754 21948210 22266823 22615860 22657828 23253856 23444773 24089143 24095737 8020957
CUL1 FANCM â—¼   ENZYMATIC_REACTION ✅ 17.0 1.0 ACSN 11900249 12648680 12820959 15071497 15147722 15340381 15459660 15688063 15703371 16697054 17884153 18931676 19270156 19622404 19686080 19809470 19847258
PLK1 FANCM â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11073952 17596790 18931676 19270156 19622404 19686080 8127874
FAAP24 FANCM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 23999858 18995830 23932590 19622405 20347429 17289582 20347428 21331524 20064461 18285517
PLK1 FANCM â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 18931676 19270156 19622404 19680264 19686080
RPA2 FEN1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11687589 9214649 11601988 10744741
WRN FEN1 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 11283614 11756412 12202749 14624239 14726013 15385537 15703371 15871698 16216273 16449207 16697054 17055429 17116323 17965729 18398454 18524993 18558713 18584027 18809224 19068479 19490890 1974050 19847258 20027199 20056333 20064462 20691907 20713526 21376743 2191300 22021614 22657828 22743550 22973052 23082994 23161013 23253856 23414611 24036544 24050180 24709898
RPA1 FEN1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11687589 9214649 11601988 10744741
RPA3 FEN1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11687589 9214649 11601988 10744741
POLD1 FEN1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11687589 9214649 11601988 10744741
NBN FEN1 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 25642960 25789972 11440997 25643323 20483915 25642963 15135726 16012167 11340072
FEN1 RBBP8 â—¼   PHYSICAL_INTERACTION 9.0 1.0 Reactome 25642960 25789972 11440997 25643323 20483915 25642963 15135726 16012167 11340072
WRN FEN1 â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 11283614 11756412 12202749 14624239 14726013 15385537 15703371 15871698 16216273 16449207 16697054 17055429 17116323 17965729 18398454 18524993 18558713 18584027 18809224 19068479 19490890 1974050 19847258 20027199 20056333 20064462 20691907 20713526 21376743 2191300 22021614 22657828 22743550 22973052 23082994 23161013 23253856 23414611 24036544 24050180 24709898
WRN FEN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 17145710 14657243 12356323 11598021 16326861 10893179 14688284
IRS1 GRB2 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 8316835 8810325 9832424 8621421 8530377 9852124 9003010
GRB2 FLT4 â—¼   PHYSICAL_INTERACTION 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
GRB2 BRAF â—¼   PHYSICAL_INTERACTION 48.0 1.0 ACSN 10086337 10567412 10811803 10843677 10982827 11023813 11034387 11062502 11385609 11447289 11777939 11907067 12040186 12175651 12419216 12640133 12782630 14585353 14764585 15169888 15536084 15547943 15567848 15574420 15735649 15863030 16102570 16227978 16488589 16582911 16887996 17178906 17395718 17496910 17613518 17673906 19449109 19541618 19565474 19568798 19615955 21102635 22435554 24027568 26552706 7510700 8551221 9510155
GRB2 RAC1 â—¼   PHYSICAL_INTERACTION 32.0 1.0 ACSN 10086337 10567412 10811803 10982827 11274345 11447289 11756498 11777939 12040186 12175651 12640133 12738796 14585353 15567848 15574420 15863030 16102570 16582911 16887996 17496910 17673906 18000759 18855897 19151919 19449109 19568798 21614932 24027568 26552706 27331412 7510700 8551221
GRB2 RAC1 â—¼   SHARES_COMPLEX 32.0 1.0 ACSN 10086337 10567412 10811803 10982827 11274345 11447289 11756498 11777939 12040186 12175651 12640133 12738796 14585353 15567848 15574420 15863030 16102570 16582911 16887996 17496910 17673906 18000759 18855897 19151919 19449109 19568798 21614932 24027568 26552706 27331412 7510700 8551221
GRB2 FLT4 â—¼   SHARES_COMPLEX 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
GRB2 BRAF â—¼   SHARES_COMPLEX 48.0 1.0 ACSN 10086337 10567412 10811803 10843677 10982827 11023813 11034387 11062502 11385609 11447289 11777939 11907067 12040186 12175651 12419216 12640133 12782630 14585353 14764585 15169888 15536084 15547943 15567848 15574420 15735649 15863030 16102570 16227978 16488589 16582911 16887996 17178906 17395718 17496910 17613518 17673906 19449109 19541618 19565474 19568798 19615955 21102635 22435554 24027568 26552706 7510700 8551221 9510155
HRAS GRB2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
IRS1 GRB2 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 10086337 10826997 12175651 12444011 12767520 16931767 17604717 19030972 21540285 22465479 24036369 8621421
GRB2 FLT4 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
PTEN GRB2 â—¼   REGULATES ✅ 15.0 1.0 ACSN 10648629 10753747 11747822 12040186 15584861 15721744 16288286 16982858 17218262 19847259 22179046 22465479 23732914 24254977 25364523
PDGFRB GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 7935391 16713569 7486683
PTEN GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16288286 10648629 17218262 12040186 15584861
BTK GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20936779 19380743
FLT4 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9927207 8662748 7675451 7970715
FGFR2 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 22726438 19735729 26103942 20554525 23420874
IRS1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 8265614 7862167 11788580 8388384 8491186 8536716 7488107 7486683 10358772 10592173 8196603 12173038 12679424 8114695 11259577 8810325
FLT3 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10080542
GRB2 HRAS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17496910 16713569 17673906 11352655
TP53 HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15358769 15284248 24451373 18996350
HSP90AA1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 12427754 10557093 21460846 16713569 11507088
SQSTM1 KEAP1 â—¼   PHYSICAL_INTERACTION 11.0 1.0 ACSN 15340068 16252010 20531300 21981924 23850759 25002027 26587781 26653790 26794443 27048822 28574505
SQSTM1 KEAP1 â—¼   PROTEIN_INTERACTION 11.0 1.0 ACSN 15340068 16252010 20531300 21981924 23850759 25002027 26587781 26653790 26794443 27048822 28574505
SQSTM1 KEAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 34.0 1.0 Omnipath 20378532 35044719 20495340 25416956 25939382 23117207 32075457 20452972 24322982 20562859 25910212 26043024 33397898 23795962 27631370 33603948 20421418 32296183 23242280 19615732 31169361 20173742 24011591 21482715
HRAS MAPK1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
MAPK1 MAP2K2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11802164 15239952 21779496 11802165 15260967
FGFR2 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
MAPK1 CUL1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 31434245 22955283 12748172 16009132
SP1 MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12220517 16797880 20506264 20121399 20882567 18372343 10727414 21170990 17889508
MAP2K2 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 68.0 1.0 Omnipath 21675959 11704645 9694850 17081983 7565670 12750173 19690332 12932319 11823456 18799465 15592455 11337027 18083107 21365009 12788955 11134045 19219045 17389395 9447970 15342917 23331499 19534553 17569879 7559390 23047924 8226933 8223433 17272394 15851026 15811950 19494114 18988627 18669648 11549292 23519423 19541618 18691976 1381507 16293107 17906627 11986622 19933846 8376945 19053285 16094384 11971971 17192257 11136732 11948414 8388392 7898932 9731057 11730323 18039929 11118451 19369195 12920017 15951569 15466214 10746662
MAP2K1 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 149.0 1.0 Omnipath 21675959 9694850 17081983 10757792 11319218 18799465 15592455 12788955 19415658 12697810 17389395 9447970 15342917 8226933 15851026 12270934 12644307 17255949 10998418 11242034 1378617 1381507 17906627 11986622 8376945 8157000 7992057 11948414 9731057 19651622 11251083 11266467 18707149 14743221 11279118 11704645 12750173 12932319 16497976 11337027 23331499 12048245 7559390 17272394 15811950 19494114 18669648 18691976 11741894 15972258 19053285 16094384 17192257 7898932 24623782 9166761 19369195 21336309 12920017 15466214 17016520 19901323 1712480 19690332 11823456 9032297 11134045 12876277 19534553 10995751 20068231 21506533 8223433 8248196 16153436 12594221 10567369 19933846 17563371 11730323 29175850 11352917 16135787 15951569 19058874 15212693 23241949 9560161 91184134 18083107 16887817 18578522 17569879 21071413 9148935 18452278 1330321 8670897 19541618 10777511 15935618 12925710 11971971 9765155 11136732 11118451 12082107 12952943 10746662 21768338
MAPK1 CEBPB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 16009338 12213825 8384717 10995751 12048245 15878863 21980398 19443782 17570479 19413330 19723873 15367685
MAPK1 SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 19318349 20882567 16377629 18775330 8226933 14744793 16079281 11904305 9604935 15212693 14593115 8388392
MAPK1 MITF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 21887372 10952390 16162175 29121864 9440696 10673502 12819038 20701798 27428965 16246839
MAPK1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 15655247 10949034 15528270 18372406 15461668 12118371 12466266 7495695 17615152 15059947 16076840 7491495 12093745 10409727 9528769 7838153
MAPK1 PML â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 22935031 29416846 23293771 23316480 15093545
MAPK1 BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 14654779 21478863 19541618 16508002 19710016 19933846 15664191 29335436 8621729
MAPK1 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 37.0 1.0 Omnipath 15001544 17081983 18949383 16123357 27014871 16914728 17360977 16099428 30401435 16131083 17640984 12510059 15613682 21850561 14579029 20594869 8626671 9395471 19651622 15576463 22289259 14769130 16020478 17242212
MAPK1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 14965474 9765199 15116093 21675959 23443559 10781582 25241761 10446957 10958792 11409876 11709713 21147777 10673501 11551930 15867353 11875057 12091386
MAPK1 CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 24342355 17290218
MAPK1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15073167 16888388 16691505
MAPK1 LRP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17496910 18039929 19541618 21965663 20974802 19565474 15547943 12063245 12738796 11226259
MDC1 ABRAXAS1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 18077395 17525340 18001825 18001824 18006705
MDC1 TP53BP1 â—¼   DOWN_REGULATES ✅ - 13.0 1.0 ACSN 12607003 15279786 15459660 17303408 17660363 18001824 18006705 18087291 18583988 18590585 18678890 7575488 9407949
CSNK2A1 MDC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 20711462 20507565 19118383 18411308 21576760 18678890 18583988 15066279 20471329 19230643 21592330 21118972 18006705 20533398
H2AX MDC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 21676867 14519663 18001824 21293379 16427009 16377563 18583988 21622030 18001825 12607005 19234442 20159462 15201865
MDC1 TP53BP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16009723 17145710 18087291 17925396 12607005
MDC1 NBN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 17145710 15201865 20460517 23115235 14519663 18001824 18678890 19804756 18583988 19230643 12607003 12607005 20224574
MSH2 MSH6 â—¼   PHYSICAL_INTERACTION 26.0 1.0 ACSN 11307145 11948476 12556884 12947387 15136767 15703371 16332722 16612326 16697054 16713580 16858402 16879101 17129768 17303408 17395641 18157157 18406444 18543256 19151707 19473888 19595721 19596235 19596236 19847258 20478261 23507534
MSH2 MSH6 â—¼   SHARES_COMPLEX 26.0 1.0 ACSN 11307145 11948476 12556884 12947387 15136767 15703371 16332722 16612326 16697054 16713580 16858402 16879101 17129768 17303408 17395641 18157157 18406444 18543256 19151707 19473888 19595721 19596235 19596236 19847258 20478261 23507534
NBN UIMC1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 18077395 17525340 18001825 18001824 18006705
NBN BARD1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
NBN RMI1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
NBN ABRAXAS1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 18077395 17525340 18001825 18001824 18006705
RAD51B PALB2 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 19268590 17996710 19369211 17996711 20871616 20871615 28089683 12912992
RAD51D PALB2 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 19268590 17996710 19369211 17996711 20871616 20871615 28089683 12912992
PALB2 RAD51 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19423707 20871616 24141787
ABRAXAS1 PIAS4 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 18077395 17525340 18001825 18001824 18006705
PIAS4 UIMC1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 18077395 17525340 18001825 18001824 18006705
TP53 PLK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 17172872 17981789 15024021 22405092 20962589 24076372 23948487 15016801 22184120 19713933 16369493 23474762
PLK1 FADD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 25949173 20890306
PLK1 TP73 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 18418051 23948487 18174154 22084676
PLK1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 22653443 19833129 16753148 23948487
PLK1 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 15849359 8349691
PLK1 TPT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 12167714 20068231 17287340 21187478 18669648
PLK1 TP53BP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20126263 25607646 24703952
PLK1 TOPORS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 22852086 26899266 22018829 24265276 19053840 24667170 26872363 19821153 19473992
TP73 PMAIP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17700533 20591651 20195489 20160496
ESR1 PMAIP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18414489 22216287
TP53 PMAIP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 10807576 23959540 15580300 19797274 15856024 20591651 22216287 14695212 14500851 20195489 21969549 18042711 20160496 15598651
CDK5 PMAIP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 26411306 25748272 23395270 21145489 25829494
CSNK2A1 PML â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 17145710 16873060 19380586
POLA1 POLD1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 8104944 1682322 1671046 9191022 1974050 10751307 7713898 7378348
POLA1 POLD1 â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 Reactome 1671046 8104944 8144677 9081985 1974050 1328683
RPA2 POLK â—¼   PHYSICAL_INTERACTION 37.0 1.0 ACSN 11756412 11900249 12648680 12930902 14624239 14726013 15189466 15459660 15703371 16697054 17116885 17296725 17582221 17652783 17884153 18087292 18196958 18584027 18677104 18809224 19258535 1974050 19772495 19793801 19809470 19847258 20211143 20227374 20478261 21282463 21376743 22021614 22743550 23414611 24050180 8264637 8978692
RPA2 POLK â—¼   SHARES_COMPLEX 37.0 1.0 ACSN 11756412 11900249 12648680 12930902 14624239 14726013 15189466 15459660 15703371 16697054 17116885 17296725 17582221 17652783 17884153 18087292 18196958 18584027 18677104 18809224 19258535 1974050 19772495 19793801 19809470 19847258 20211143 20227374 20478261 21282463 21376743 22021614 22743550 23414611 24050180 8264637 8978692
RAD51 BARD1 â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
RAD51 XRCC3 â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
RAD51 XRCC3 â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
RAD51 BARD1 â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
PTEN RAD51 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 10753747 11747822 12040186 15721744 16288286 16982858 17218252 17218262 18716620 19847259 22179046 22465479 23732914 24254977 25364523
TP53 RAD51 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17513613 16322760 20802511 16398215 18769160
RECQL5 RAD51 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20348101 22645136
XRCC3 RAD51 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9660962 23438602 28864920 11842113
TP53 RAD51 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 8617246 11002423 16713569 16322760 16983346 9380510
WRN RBBP8 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
RBBP8 RMI1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
BARD1 RMI1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
RPA3 RPA1 â—¼   PHYSICAL_INTERACTION 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA2 RPA1 â—¼   PHYSICAL_INTERACTION 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA1 TOPBP1 â—¼   PHYSICAL_INTERACTION 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
RPA1 MCM3 â—¼   PHYSICAL_INTERACTION 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA2 RPA1 â—¼   SHARES_COMPLEX 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA3 RPA1 â—¼   SHARES_COMPLEX 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA1 MCM3 â—¼   SHARES_COMPLEX 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA2 RPA1 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA3 RPA1 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA1 MCM3 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA1 TOPBP1 â—¼   DOWN_REGULATES ✅ - 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
RPA1 TOPBP1 â—¼   REGULATES ✅ 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
RPA1 WRN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 17145710 14499497 24126761 24332808 10373438 15735006 15965237 26474068 14734561
RPA2 MCM3 â—¼   PHYSICAL_INTERACTION 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA2 SPRTN â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 23042605 16139798 24768535 23042607
RPA2 RPA3 â—¼   PHYSICAL_INTERACTION 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA2 TOPBP1 â—¼   PHYSICAL_INTERACTION 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
RPA2 RPA3 â—¼   SHARES_COMPLEX 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA2 MCM3 â—¼   SHARES_COMPLEX 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA2 MCM3 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA2 RPA3 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA2 TOPBP1 â—¼   DOWN_REGULATES ✅ - 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
RPA2 TOPBP1 â—¼   REGULATES ✅ 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
RPA3 TOPBP1 â—¼   PHYSICAL_INTERACTION 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
RPA3 SPRTN â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 23042605 16139798 24768535 23042607
RPA3 MCM3 â—¼   PHYSICAL_INTERACTION 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA3 MCM3 â—¼   SHARES_COMPLEX 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA3 MCM3 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 11900249 12648680 14624239 15459660 15703371 16697054 17102137 17116885 17296725 17582221 17884153 18677104 19793801 19809470 19847258
RPA3 TOPBP1 â—¼   DOWN_REGULATES ✅ - 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
RPA3 TOPBP1 â—¼   REGULATES ✅ 43.0 1.0 ACSN 10884395 11877377 11900249 12086603 12648680 12766152 12875843 14624239 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16880517 16885023 16934469 17102137 17116885 17141802 17296725 17303408 17384638 17493829 17582221 17884153 18469862 18677104 18995830 19282663 19342888 19622404 19793801 19809470 19847258 20051983 20478261 8943031 9524127
SQSTM1 FADD â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 12702723 15340068 16252010 16498403 20531300 21981924 23069999 25002027 26587781 28574505 9184224
SQSTM1 FASLG â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 12702723 15340068 16252010 16498403 20531300 21981924 23069999 25002027 26587781 28574505 9184224
SP1 SQSTM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9762895 12736330 17012241
MAP1LC3A SQSTM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 54.0 1.0 Omnipath 20061800 23022382 23459205 35044719 22963397 36036324 31053714 21045561 25921531 19250911 17580304 21628531 20204693 28740232 23640897 25686248 24100292 26075355 20562859 22658522 25984893 21460636 16286508 19427866 32296183 23989536 19021777 26268733 22714671 24998849 18653543 31366950 33436498 16169070 23239879 26754771
TOPORS TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 17803295 17290218 11842245 16713569 15247280 10415337 19473992 16122737
TP53 CDK5 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 10604467 17591690 12064478 18490454 10500146
ESR1 TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 20080630 16115928 22787161 12750288 20696891 17681750 17699779
RELA TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 18269916 10348347 11032029 8051093 20061391 15155458 21332394 9890939 21887328
CEBPB TP53 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19135161 23564453 19075931 24333671
TP53 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 19057620 15632413 11466559 19448667 19880525 9891054 22198284 10833421 11709699 10435630 11390631 9890939 21191649 12501250 11928223 17434128 12164786 24330748 11779500 10435595 21513889 10777477
TP53 HRAS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21552926 9662334 11127813 21552928
TP53 PDGFRB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19952113 19763735 18697203
TP53 SP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 19846904 15790310 11118296 11384995 21611785 7478550 15967108 18419600 19244234 9865734 18769160
TP53 FASLG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17196791 9889415 20393600 9841917
TP53 PTEN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 22957312 15843377 12917634 21637289 17344317 12839924 11545734 18172008 19173293 20554748 19079342 14984207
CSNK2A1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 53.0 1.0 Omnipath 23443559 15358769 9315650 19413330 11285227 11551930 11883897 22975381 11709713 16083285 1088347 33745968 16552184 10884347 10747897 10673501 7936649 12628923 25241761 21127074 16964247 24725084 10606744 10348343 10951572
CSNK2B TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 10606744 11709713 10214938 10951572 16713569 11551930 10747897 10673501 11883897
TP53BP1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 25579814 12110597 25837623 16713569 14978302 22653443 26022179 27546791 8016121 12351827 15611139 15364958 14985081 19433796 17805299 25651062 11877378 17634560 22084066 20307547
WRN TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 12080066 11399766 15735006 16713569 11427532
PIAS1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 25241761 15133049 10380882 20805487 11867732 16713569 11583632 11788578
CREBBP TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 49.0 1.0 Omnipath 17303408 25545885 27618436 19220000 16713569 10823891 15632413 19805293 25451029 15279786 10473588 12154097 7575488 16537920 10848610 18485870 19880525 10648616 20144767 14722092 14759370 18590585 26976603 9194564 19788416 25314079 19166313 12426395 9288775 11782467 17660363 19234109 21390126 10196247 17434128 19357310 10551785 22084066
PRKAA1 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 28797070 15866171
CDK5 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 44.0 1.0 Omnipath 9372954 21317932 11483158 11740489 19413330 19664995 21600237 11554766 11709713 16552184 10884347 16377624 17591690 15866171 17287340 17967874 92065884 11780126 12064478 10570149 26146988 15701641 17117479 17108107 14702041
TP53 PTEN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 21336307 18431400 18339852 12620407 17409411 18172008 17823410 16713569 21518799 21483453
TP53 TP73 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11238924 18431400 21508668 9891077
TP53 WRN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 12080066 11399766 15735006 16713569 11427532
TP53BP1 ABRAXAS1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 18077395 17525340 18001825 18001824 18006705
TP53BP1 UIMC1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 18077395 17525340 18001825 18001824 18006705
TP53BP1 UIMC1 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11042216 11877378 17243194 18087291 19342239 20646866 9748285
TP53BP1 BARD1 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11042216 11877378 17243194 18087291 19342239 20646866 9748285
H2AX TP53BP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 17145710 20075863 18001824 21317870 12447390 17024177 18001825 21566653 12607005 12697768 21623170
TP73 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10648616 21245298 11172610 10435630
BARD1 UIMC1 â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 11877377 15459660 16697054 19342239 19772495 19793801 19847258 20029420 21060331 21337561
H2AX UIMC1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 18077395 17525340 18001825 18001824 18006705
BARD1 UIMC1 â—¼   SHARES_COMPLEX 10.0 1.0 ACSN 11877377 15459660 16697054 19342239 19772495 19793801 19847258 20029420 21060331 21337561
WRN BARD1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 22021381 16153896 18923075 18805091 21325134 22792074 19419957 21052091 18971343 25122754 11301010 21240188
BARD1 XRCC3 â—¼   PHYSICAL_INTERACTION 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
BARD1 XRCC3 â—¼   SHARES_COMPLEX 35.0 1.0 ACSN 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773
H2AX ABRAXAS1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 18077395 17525340 18001825 18001824 18006705
ACTB CDC42 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 24914801 15507212 16439214 22608513
PFN1 ACTB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 17541406 8413665 563468 10600384 10411937 10592173 19000816 16189514 19338310 9463375
CSNK2A1 CSNK2B â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
DVL1 CSNK2B â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7744250 21285348 10698942 9192851 9214626
ESR1 TFF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 21984905 19858291 11517191 18543253 19935720 17317669 22382029 18414489 17938209 19462000 18322535 22093877 16219765 19933843 16087863 15541729 10037443 22543272 16651411 20422012 23874775
SP1 TFF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18543253 15987735 15541729
CASP8 FADD â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
FADD FASLG â—¼   PHYSICAL_INTERACTION 52.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9184224 9217161 9488730 9759866
FADD CASP8 â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 11003656 15325588 17462996 20531300 23725295 24070470 26587781 26972597 28574505 9488730
FADD CASP8 â—¼   SHARES_COMPLEX 10.0 1.0 ACSN 11003656 15325588 17462996 20531300 23725295 24070470 26587781 26972597 28574505 9488730
FADD FASLG â—¼   SHARES_COMPLEX 52.0 1.0 ACSN 11003656 11274345 1134007 11583996 12215447 12702723 12724420 14744430 15592525 15760909 16406523 16498403 16940415 17462996 18545270 18641653 19392652 19427028 19498109 19524512 19524513 19597341 19632174 19838173 20452955 20531300 21133840 21232017 22421439 22427918 23010170 23069999 23073834 23377657 23850759 24366341 24378531 26024392 26587781 26653790 26853145 26900751 26972597 27558815 27984721 28498367 28574505 28645028 9184224 9217161 9488730 9759866
FADD CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 82.0 1.0 Omnipath 22864571 17145710 11717445 19524512 34591612 15280356 17047155 27552911 12911633 25043603 21458669 11788820 19176810 21525013 21988832 22179575 25939870 12702723 21737330 21741934 26437781 25911380 9228018 21785459 20829884 23972990 21620750 12220669 9774341 17159907 10521396 27321185 17290218 27560715 20103630 24098568 20203691 14612908 8681377 18485876 12107169 15659383 22421964 20448643 9343261 20125124 8681376 12887920 19060883 21737329 23142077 22173242 26972597 22274400 19935698 16410793
CDC42 TUBGCP2 â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10934474 11248548 11340065 15001467 15003621 15020669 15169870 15882626 16329184 17517963 17785506 18719708 19741094 21178402 22126964 22821962 27248291 7761442 9831565
CSNK2A1 PTEN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 34.0 1.0 Omnipath 16107342 33760042 18723495 25823029 21840932 10866658 24766807 16690621 21779440 24706748 19662498 28263967 15987703 11035045 12077256 24047694 11707428 22413754 17444818 26832662 12297295
HRAS MAP2K2 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
SP1 HRAS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 8106522 8208618 3012774 11559711 21931711 8027084 1776841
HRAS BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 17145710 7706312 14970219 18567582 12932319 8073291 1386920 23331499 8601312 9154803 18988627 8668348 21779497 19541618 19933846 17563371 18098337 16803888 26165597 24441586 16135787 12917261 15710605 10545207
DVL1 LRP6 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL1 CSNK2A1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 7744250 21285348 10698942 9192851 9214626
CXXC4 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 18931698 11113207 15108311
CSNK2A1 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 10837139 20976471 10806215 25241761 20558317 10671551 17374729 21285348 11972058 21506126 11689703 10747897 16707567
DVL1 RAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23331499 15608632 19365405 12533515 17363564
CSNK2A1 MAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 19651622 11535131 17081983 8247525 8018564 18691976 9115440 20068231 18452278 19413330 7735324
CCNE1 CUL1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 16209941 10375532 15199159 11231585
RELA CUL1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9990852 10514433 9859996 9990853 7628694
CUL1 PPP3CB â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 11900249 12648680 12820959 15071497 15340381 15459660 15489953 15688063 15703371 16697054 17884153 18931676 19622404 19686080 19809470 19847258
CUL1 GLI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 17053147 15340381 16611981 18813803 16651270 12820959 19797085 15071497 15688063 16371461
CUL1 CCNE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 19847258 19686080 19270156 17884153 19622404 15703371 12648680 11900249 16697054 18931676 19809470 15459660
SP1 FASLG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 10075666 20617570 11254710 11053446 14563113 10754388 18293083 15659839 11970950 12655294 17192273 11745351 15173177 15004200 10671224
CEBPB FASLG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12496392
PRKACB RELA â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17462920 12628924 19197368 19122653 18385332
SP1 RELA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 7636984 8450395 9151857 20538607 11964305
RELA IL4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 15048722 14688382 19915002 20139176 8524816 12516545 8135784 8083467 21989417 25037220
CREBBP RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 10542243 14597638 18241676 17138826 15140884 9096323 16713569 12456660 10454579 16382138 19608861 9806899 25314079 11931769 12163591 12881425 9659924 15171256 9548485 16291753 17362989 25733689 17434128 15334063 15806143 10235267 17296604
CSNK2A1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 34049972 15016307 10938077 27630163
RELA SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12055073 7933095 10671503 20861353
CEBPB CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17067998 8654374 10818089 15722556 15388792 17599912 12857754
SP1 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23297421 20096088 9765204 21191649 21464950 12200429 20130956 12169688 15576380 15184875 15713621 18571793
CREBBP ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9192902 18765668 16417649 11113179 8616895 11782371 14766010 17400812
SP1 IL4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14603527 15739164 11133225 12905482
CEBPB IL4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 15048722 19915002 16585579 12516545 7594540 15922518 8709636 9442389 11009091 23913966
RAC1 MAP2K2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17496910 18000759 15574420 19151919 11777939 18855897 21614932 12738796 11274345 12040186 19568798 14585353
RAC1 MAP2K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17496910 18000759 15574420 19151919 11777939 18855897 21614932 12738796 11274345 12040186 19568798 14585353
FZD8 LRP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11448771 21078818 11029007 20093360
SP1 UGDH â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16002992 21576248 12682078 18717819
SP1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 12237165 19351845 11345900 21235772 23209644 12429135 18006846 10982795 22622808 15691879 21191649
SP1 BTK â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11254710 11779634 7721790 10362515 8562928
CSNK2A1 SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 9153193
FGF3 FGFR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23331499 75926248663044 16597617 8663044 7592624 25772309
FGF7 FGFR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 16597617 11714710 23331499 7687739 21071413 10339576 125919597687739 25772309 1309608 9582367 27192911 12591959 10950949 11121055 8663044
CDK5 MAP2K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 18691976 25971971 8114697 11684694 15665076 10567369 8157000 12609978
ESR1 CEBPB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19652226 18414489
CEBPB CCNE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16120603 22722334 19407981 11162569
CSNK2A1 PIAS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 24174529 19217413
PIAS1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15666801 11117529
BRAF MAP2K1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 67.0 1.0 Omnipath 20212043 7706312 25437913 9560161 7936666 14970219 18567582 18332145 8413257 23331499 15342917 21071413 7731720 7873542 26496610 10976102 18988627 17667937 16255777 8131746 16888650 15485920 8394352 15175348 15466476 19541618 25600339 25155755 17563371 16810323 8157000 17979178 18039929 94178255 23934108 7835430 7624324 24746704 16135787 7935374 8039496 8621729
BRAF MAP2K2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 23331499 15342917 18039929 19541618 7706312 15466476 25600339 7731720 16135787 17563371 33226073 8668348 17667937 16255777
CSNK2A1 HNRNPC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 32.0 1.0 Omnipath 19651622 20058876 17081983 20166139 15687492 18691976 20068231 18452278 19664995 17693683 17287340 19413330 12564933 18669648 15302935
CSNK2A1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 11139588 26703694 9337862 20043841 11432835 11507039 9528769 7838153
JAG2 NOTCH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 23331499 21071413 16921404 16713569 10958687 18988627 22353464
PRKAA1 ULK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 24820971 23372762 28295473 21460634 19584320 21205641 21258367 28389629 34421918 34224814 25980607 32978258
MITF BIRC7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19067971 1999537 18451137 23480510
UHRF2 CCNE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15178429 21952639